FAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)4.81624616
2paraxial mesoderm development (GO:0048339)4.47336473
3bundle of His cell to Purkinje myocyte communication (GO:0086069)4.45209905
4dichotomous subdivision of an epithelial terminal unit (GO:0060600)4.37215413
5hippo signaling (GO:0035329)4.29911085
6collagen fibril organization (GO:0030199)4.19496428
7chondrocyte proliferation (GO:0035988)4.09354418
8planar cell polarity pathway involved in neural tube closure (GO:0090179)4.05132080
9polarized epithelial cell differentiation (GO:0030859)3.96195576
10bone trabecula formation (GO:0060346)3.90169124
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.88344158
12regulation of transforming growth factor beta2 production (GO:0032909)3.85683639
13negative regulation of keratinocyte proliferation (GO:0010839)3.84185449
14keratinocyte proliferation (GO:0043616)3.76167243
15mammary gland epithelial cell proliferation (GO:0033598)3.72112309
16neuron projection extension involved in neuron projection guidance (GO:1902284)3.70026949
17axon extension involved in axon guidance (GO:0048846)3.70026949
18establishment of apical/basal cell polarity (GO:0035089)3.65063728
19endocardial cushion development (GO:0003197)3.62792741
20protein heterotrimerization (GO:0070208)3.60408154
21craniofacial suture morphogenesis (GO:0097094)3.59295617
22glomerular visceral epithelial cell development (GO:0072015)3.55511690
23regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.54986661
24endodermal cell differentiation (GO:0035987)3.52104133
25hemidesmosome assembly (GO:0031581)3.48367616
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.48116796
27sequestering of extracellular ligand from receptor (GO:0035581)3.46342107
28hypotonic response (GO:0006971)3.45370485
29glomerular basement membrane development (GO:0032836)3.36476268
30G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.36448817
31branching involved in mammary gland duct morphogenesis (GO:0060444)3.32284222
32cell adhesion mediated by integrin (GO:0033627)3.32244518
33epithelial cell-cell adhesion (GO:0090136)3.32235300
34renal filtration (GO:0097205)3.32121900
35chondrocyte development (GO:0002063)3.30732109
36cytoskeletal anchoring at plasma membrane (GO:0007016)3.28424063
37regulation of hippo signaling (GO:0035330)3.25274759
38anterior/posterior axis specification, embryo (GO:0008595)3.23353225
39endothelial cell morphogenesis (GO:0001886)3.19872347
40Golgi transport vesicle coating (GO:0048200)3.17768314
41COPI coating of Golgi vesicle (GO:0048205)3.17768314
42morphogenesis of an epithelial sheet (GO:0002011)3.16186108
43gap junction assembly (GO:0016264)3.14478952
44positive regulation of SMAD protein import into nucleus (GO:0060391)3.12841750
45negative regulation of chondrocyte differentiation (GO:0032331)3.12112466
46establishment of monopolar cell polarity (GO:0061162)3.11395934
47establishment or maintenance of monopolar cell polarity (GO:0061339)3.11395934
48nuclear pore complex assembly (GO:0051292)3.08514187
49negative regulation of DNA repair (GO:0045738)3.06073642
50negative regulation of catenin import into nucleus (GO:0035414)3.05312159
51cranial suture morphogenesis (GO:0060363)3.02969668
52regulation of SMAD protein import into nucleus (GO:0060390)3.02968330
53regulation of catenin import into nucleus (GO:0035412)3.02120799
54pore complex assembly (GO:0046931)3.01915370
55positive regulation of endothelial cell apoptotic process (GO:2000353)3.01423355
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00385686
57branching involved in salivary gland morphogenesis (GO:0060445)2.95942508
58cellular response to vitamin D (GO:0071305)2.94724440
59basement membrane organization (GO:0071711)2.93935814
60positive regulation of catenin import into nucleus (GO:0035413)2.93752492
61regulation of posttranscriptional gene silencing (GO:0060147)2.92966366
62regulation of gene silencing by miRNA (GO:0060964)2.92966366
63regulation of gene silencing by RNA (GO:0060966)2.92966366
64mesenchymal-epithelial cell signaling (GO:0060638)2.91876973
65cell migration involved in sprouting angiogenesis (GO:0002042)2.89971305
66adherens junction assembly (GO:0034333)2.88026587
67gastrulation with mouth forming second (GO:0001702)2.86783096
68glomerular filtration (GO:0003094)2.86701218
69plasma membrane repair (GO:0001778)2.86362843
70outer ear morphogenesis (GO:0042473)2.85922481
71mesodermal cell differentiation (GO:0048333)2.84372359
72Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83341264
73cellular response to vitamin (GO:0071295)2.83069799
74wound healing, spreading of epidermal cells (GO:0035313)2.83028395
75cell-substrate junction assembly (GO:0007044)2.82875453
76skin morphogenesis (GO:0043589)2.82870834
77mesenchyme development (GO:0060485)2.82868246
78nuclear pore organization (GO:0006999)2.81116106
79focal adhesion assembly (GO:0048041)2.79816957
80cell-substrate adherens junction assembly (GO:0007045)2.79816957
81regulation of establishment of planar polarity (GO:0090175)2.78417782
82notochord development (GO:0030903)2.78320989
83negative regulation of stem cell proliferation (GO:2000647)2.78003321
84protein localization to cell surface (GO:0034394)2.76687623
85establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.76066038
86dorsal/ventral axis specification (GO:0009950)2.74379118
87activation of Rac GTPase activity (GO:0032863)2.73507205
88lung-associated mesenchyme development (GO:0060484)2.72735193
89lateral sprouting from an epithelium (GO:0060601)2.71155763
90bone remodeling (GO:0046849)2.69023447
91collagen metabolic process (GO:0032963)2.69013714
92negative regulation of fatty acid transport (GO:2000192)2.68677050
93regulation of cardioblast differentiation (GO:0051890)2.67798345
94convergent extension (GO:0060026)2.67433996
95COPII vesicle coating (GO:0048208)2.67384727
96positive regulation of mesenchymal cell proliferation (GO:0002053)2.67301847
97axis elongation (GO:0003401)2.66228621
98regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.65319272
99multicellular organismal macromolecule metabolic process (GO:0044259)2.63765977
100collecting duct development (GO:0072044)2.62345395
101collagen catabolic process (GO:0030574)2.62211408
102non-canonical Wnt signaling pathway (GO:0035567)2.61470186
103regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.60078711
104glial cell proliferation (GO:0014009)2.59287791
105negative regulation of embryonic development (GO:0045992)2.59075366
106metanephric mesenchyme development (GO:0072075)2.58490680
107embryonic cranial skeleton morphogenesis (GO:0048701)2.57360126
108substrate adhesion-dependent cell spreading (GO:0034446)2.57352596
109positive regulation of epithelial to mesenchymal transition (GO:0010718)2.57263354
110pre-miRNA processing (GO:0031054)2.55580879
111regulation of keratinocyte proliferation (GO:0010837)2.55166241
112regulation of cell fate specification (GO:0042659)2.54945655
113apoptotic cell clearance (GO:0043277)2.54878592
114negative regulation of cartilage development (GO:0061037)2.54825913
115embryonic retina morphogenesis in camera-type eye (GO:0060059)2.54342378
116regulation of tight junction assembly (GO:2000810)2.54200875
117cell surface receptor signaling pathway involved in heart development (GO:0061311)2.53791975
118mitotic cytokinesis (GO:0000281)2.53514615
119bone morphogenesis (GO:0060349)2.53268681
120cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.52670836
121camera-type eye morphogenesis (GO:0048593)2.52489233
122multicellular organismal catabolic process (GO:0044243)2.51322224
123mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.51247516
124embryonic foregut morphogenesis (GO:0048617)2.50985069
125anatomical structure regression (GO:0060033)2.50384542
126establishment of tissue polarity (GO:0007164)2.50358238
127establishment of planar polarity (GO:0001736)2.50358238
128regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.49836049
129NLS-bearing protein import into nucleus (GO:0006607)2.49563969
130glomerular epithelial cell development (GO:0072310)2.49554147
131cytoplasmic mRNA processing body assembly (GO:0033962)2.49467083
132retina vasculature morphogenesis in camera-type eye (GO:0061299)2.49053485
133substrate-dependent cell migration (GO:0006929)2.48050710
134cell junction assembly (GO:0034329)2.44040039
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.42740370
136regulation of glucose import in response to insulin stimulus (GO:2001273)2.39560786
137mammary gland development (GO:0030879)2.36887727
138protein retention in ER lumen (GO:0006621)2.36757625
139muscle cell migration (GO:0014812)2.35538977
140smooth muscle tissue development (GO:0048745)2.35419435
141extracellular matrix disassembly (GO:0022617)2.35417790
142multicellular organismal metabolic process (GO:0044236)2.34984706
143mammary gland alveolus development (GO:0060749)2.34728215
144protein localization to endosome (GO:0036010)2.32234798
145regulation of mitotic spindle organization (GO:0060236)2.29798253
146regulation of sister chromatid cohesion (GO:0007063)2.28556027
147establishment or maintenance of apical/basal cell polarity (GO:0035088)2.27512740
148establishment or maintenance of bipolar cell polarity (GO:0061245)2.27512740
149negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.27270062
150cytoskeleton-dependent cytokinesis (GO:0061640)2.27039611
151semaphorin-plexin signaling pathway (GO:0071526)2.26594026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.48732547
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.76780582
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.92869389
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.74152946
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.55339632
6* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37152950
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.25889796
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.18761954
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.16174811
10HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.14619085
11EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.12874344
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.11133832
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.07130420
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.05755044
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.04917506
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.03117094
17CLOCK_20551151_ChIP-Seq_293T_Human2.02662099
18ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.02319772
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99175167
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.91614128
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88593973
22ESR1_15608294_ChIP-ChIP_MCF-7_Human1.88447692
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87653213
24SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.82022663
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.81334478
26ESR1_21235772_ChIP-Seq_MCF-7_Human1.80055740
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.76621955
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76237394
29BRD4_25478319_ChIP-Seq_HGPS_Human1.75038355
30TP53_16413492_ChIP-PET_HCT116_Human1.73387167
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.70180497
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67093848
33* ISL1_27105846_Chip-Seq_CPCs_Mouse1.66965100
34ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66750244
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.65624700
36TCF3_18692474_ChIP-Seq_MEFs_Mouse1.65611615
37SMAD_19615063_ChIP-ChIP_OVARY_Human1.63605236
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.63407926
39KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.61489117
40KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.61489117
41KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.61489117
42CJUN_26792858_Chip-Seq_BT549_Human1.59920428
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.58746879
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.58589019
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58285155
46SOX9_24532713_ChIP-Seq_HFSC_Mouse1.57789530
47* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55803325
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55012724
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54645545
50E2F7_22180533_ChIP-Seq_HELA_Human1.51566586
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.50063482
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.50063482
53AR_21909140_ChIP-Seq_LNCAP_Human1.47940814
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.47538362
55* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.45913510
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45366179
57FOXO3_23340844_ChIP-Seq_DLD1_Human1.45298472
58CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.45177048
59* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42842744
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.41905612
61KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40273869
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35960492
63* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35568392
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.34201572
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33585039
66NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.31772601
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.29053982
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29051957
69SALL4_18804426_ChIP-ChIP_XEN_Mouse1.29004417
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.28625135
71PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26746051
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26428197
73FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24122502
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23931300
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.23307103
76FOXA2_19822575_ChIP-Seq_HepG2_Human1.21579340
77ZNF263_19887448_ChIP-Seq_K562_Human1.21444044
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20711734
79SOX2_20726797_ChIP-Seq_SW620_Human1.18247398
80UBF1/2_26484160_Chip-Seq_HMECs_Human1.17255566
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16352911
82* TP53_23651856_ChIP-Seq_MEFs_Mouse1.15869925
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13473673
84AHR_22903824_ChIP-Seq_MCF-7_Human1.12822118
85* ATF3_27146783_Chip-Seq_COLON_Human1.12269963
86CDX2_20551321_ChIP-Seq_CACO-2_Human1.11964309
87* TP63_23658742_ChIP-Seq_EP156T_Human1.10444189
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.10153046
89* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09715605
90TP53_22127205_ChIP-Seq_IMR90_Human1.09221830
91* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09176748
92TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.08919191
93NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08831342
94NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08831342
95* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.08417246
96KDM2B_26808549_Chip-Seq_K562_Human1.08183440
97POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08044456
98* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07692228
99STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07453812
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.07189095
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05132238
102KLF5_25053715_ChIP-Seq_YYC3_Human1.04549677
103POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04213398
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04042036
105NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03862114
106FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02259765
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.01581216
108EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01375518
109PIAS1_25552417_ChIP-Seq_VCAP_Human1.00641194
110GATA6_25053715_ChIP-Seq_YYC3_Human0.99361549
111* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99178457
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99018580
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98733233
114TP53_18474530_ChIP-ChIP_U2OS_Human0.98410984
115ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98239414
116ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98171151
117RUNX1_27514584_Chip-Seq_MCF-7_Human0.96831830
118* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94927115
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93600137
120JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91975949
121MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.90073823
122* TBX20_22080862_ChIP-Seq_HEART_Mouse0.89843116
123* TBX20_22328084_ChIP-Seq_HEART_Mouse0.89843116
124SOX17_20123909_ChIP-Seq_XEN_Mouse0.88424327
125P63_26484246_Chip-Seq_KERATINOCYTES_Human0.84287543
126BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82828906
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.81331206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.96908815
2MP0003705_abnormal_hypodermis_morpholog3.99916519
3MP0005275_abnormal_skin_tensile3.46161692
4MP0005503_abnormal_tendon_morphology3.31462898
5MP0005623_abnormal_meninges_morphology2.97863890
6MP0004272_abnormal_basement_membrane2.82868470
7MP0010352_gastrointestinal_tract_polyps2.66394706
8MP0000537_abnormal_urethra_morphology2.56667245
9MP0009384_cardiac_valve_regurgitation2.46857470
10MP0010030_abnormal_orbit_morphology2.43961789
11MP0009053_abnormal_anal_canal2.36251536
12MP0003941_abnormal_skin_development2.17391771
13MP0003279_aneurysm2.02433448
14MP0003385_abnormal_body_wall2.00041307
15MP0005076_abnormal_cell_differentiation1.94591543
16MP0003566_abnormal_cell_adhesion1.93124449
17MP0003283_abnormal_digestive_organ1.92988093
18MP0001958_emphysema1.92546733
19MP0010234_abnormal_vibrissa_follicle1.91822170
20MP0005409_darkened_coat_color1.81529058
21MP0001299_abnormal_eye_distance/1.81471878
22MP0003937_abnormal_limbs/digits/tail_de1.75470845
23MP0000733_abnormal_muscle_development1.70719383
24MP0005508_abnormal_skeleton_morphology1.69246477
25MP0000428_abnormal_craniofacial_morphol1.67728436
26MP0005023_abnormal_wound_healing1.65200831
27MP0003091_abnormal_cell_migration1.64824753
28MP0000534_abnormal_ureter_morphology1.62483455
29MP0009250_abnormal_appendicular_skeleto1.60456720
30MP0003942_abnormal_urinary_system1.60206555
31MP0003950_abnormal_plasma_membrane1.56974226
32MP0005257_abnormal_intraocular_pressure1.56206886
33MP0003115_abnormal_respiratory_system1.51066973
34MP0002896_abnormal_bone_mineralization1.50683389
35MP0003755_abnormal_palate_morphology1.47661145
36MP0003453_abnormal_keratinocyte_physiol1.44668592
37MP0003045_fibrosis1.40167823
38MP0003935_abnormal_craniofacial_develop1.39499741
39MP0006054_spinal_hemorrhage1.39182786
40MP0000566_synostosis1.38373295
41MP0000432_abnormal_head_morphology1.37054289
42MP0002098_abnormal_vibrissa_morphology1.36848693
43MP0002060_abnormal_skin_morphology1.36418936
44MP0002108_abnormal_muscle_morphology1.33653663
45MP0005367_renal/urinary_system_phenotyp1.33297624
46MP0000516_abnormal_urinary_system1.33297624
47MP0002932_abnormal_joint_morphology1.32114833
48MP0004197_abnormal_fetal_growth/weight/1.27847172
49MP0005248_abnormal_Harderian_gland1.24907353
50MP0000462_abnormal_digestive_system1.24904404
51MP0010368_abnormal_lymphatic_system1.24246740
52MP0002282_abnormal_trachea_morphology1.24245075
53MP0001849_ear_inflammation1.21597862
54MP0002111_abnormal_tail_morphology1.19388368
55MP0000762_abnormal_tongue_morphology1.18854942
56MP0002084_abnormal_developmental_patter1.18210674
57MP0002249_abnormal_larynx_morphology1.16930654
58MP0003119_abnormal_digestive_system1.15818275
59MP0002796_impaired_skin_barrier1.15544654
60* MP0002697_abnormal_eye_size1.13176306
61MP0000013_abnormal_adipose_tissue1.12643544
62MP0002116_abnormal_craniofacial_bone1.12560132
63MP0004858_abnormal_nervous_system1.11123767
64MP0001216_abnormal_epidermal_layer1.10536238
65MP0005501_abnormal_skin_physiology1.10335759
66MP0000163_abnormal_cartilage_morphology1.09850297
67MP0002168_other_aberrant_phenotype1.09687673
68MP0000627_abnormal_mammary_gland1.07878438
69MP0009697_abnormal_copulation1.07699201
70MP0010678_abnormal_skin_adnexa1.07570258
71MP0002085_abnormal_embryonic_tissue1.06367407
72MP0010307_abnormal_tumor_latency1.06148517
73* MP0002233_abnormal_nose_morphology1.06134960
74MP0000467_abnormal_esophagus_morphology1.06083206
75MP0002089_abnormal_postnatal_growth/wei1.04992572
76MP0002295_abnormal_pulmonary_circulatio1.04617601
77MP0000049_abnormal_middle_ear1.04228792
78MP0009780_abnormal_chondrocyte_physiolo1.03619334
79MP0002115_abnormal_skeleton_extremities1.03405202
80MP0002109_abnormal_limb_morphology1.01315616
81MP0003315_abnormal_perineum_morphology1.00840457
82MP0002877_abnormal_melanocyte_morpholog0.99080704
83* MP0002092_abnormal_eye_morphology0.98007655
84MP0004134_abnormal_chest_morphology0.97698174
85MP0004233_abnormal_muscle_weight0.97401573
86MP0002925_abnormal_cardiovascular_devel0.96198337
87MP0003300_gastrointestinal_ulcer0.95074052
88MP0000751_myopathy0.94522368
89* MP0001293_anophthalmia0.94495686
90MP0005197_abnormal_uvea_morphology0.92255824
91MP0010771_integument_phenotype0.91077418
92MP0002113_abnormal_skeleton_development0.89198412
93MP0002938_white_spotting0.88995281
94MP0000569_abnormal_digit_pigmentation0.88695271
95MP0001348_abnormal_lacrimal_gland0.88635712
96MP0005187_abnormal_penis_morphology0.88364152
97MP0000377_abnormal_hair_follicle0.87677202
98MP0001661_extended_life_span0.86530987
99MP0002086_abnormal_extraembryonic_tissu0.86374205
100MP0000767_abnormal_smooth_muscle0.86262877
101MP0002114_abnormal_axial_skeleton0.85995170
102MP0002234_abnormal_pharynx_morphology0.85680811
103MP0003122_maternal_imprinting0.85564281
104MP0009703_decreased_birth_body0.85442346
105MP0001346_abnormal_lacrimal_gland0.84261122
106MP0003890_abnormal_embryonic-extraembry0.84259263
107MP0000383_abnormal_hair_follicle0.83544286
108MP0000003_abnormal_adipose_tissue0.83504713
109MP0001672_abnormal_embryogenesis/_devel0.82739198
110MP0005380_embryogenesis_phenotype0.82739198
111MP0001243_abnormal_dermal_layer0.82724361
112MP0002088_abnormal_embryonic_growth/wei0.82456849
113MP0000579_abnormal_nail_morphology0.82305338
114MP0003984_embryonic_growth_retardation0.82140533
115MP0003121_genomic_imprinting0.81678855
116* MP0001286_abnormal_eye_development0.81392912
117MP0003123_paternal_imprinting0.81237669
118MP0004957_abnormal_blastocyst_morpholog0.80090882
119MP0004264_abnormal_extraembryonic_tissu0.78620543
120MP0001915_intracranial_hemorrhage0.78262585
121MP0001340_abnormal_eyelid_morphology0.77563416
122* MP0005193_abnormal_anterior_eye0.77276196
123MP0004185_abnormal_adipocyte_glucose0.76519240
124MP0002009_preneoplasia0.76327049
125MP0002177_abnormal_outer_ear0.75881662
126MP0008932_abnormal_embryonic_tissue0.73919142

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.30076754
2Premature rupture of membranes (HP:0001788)4.93881710
3Shallow orbits (HP:0000586)4.92892063
4Atrophic scars (HP:0001075)3.80143590
5Ankle contracture (HP:0006466)3.78627063
6Short 4th metacarpal (HP:0010044)3.63173921
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.63173921
8Broad metatarsal (HP:0001783)3.32730565
9Arterial tortuosity (HP:0005116)3.21057250
10Aortic dissection (HP:0002647)3.18856066
11Milia (HP:0001056)3.10549717
12Cerebral aneurysm (HP:0004944)3.06664089
13Vertebral arch anomaly (HP:0008438)2.98321425
14Abnormality of the 4th metacarpal (HP:0010012)2.91943083
15Cervical subluxation (HP:0003308)2.89912680
16Bladder diverticulum (HP:0000015)2.87276476
17Aortic aneurysm (HP:0004942)2.86459202
18Fragile skin (HP:0001030)2.79435105
19Genu recurvatum (HP:0002816)2.75603001
20Mitral valve prolapse (HP:0001634)2.67823546
21Dilatation of the ascending aorta (HP:0005111)2.61868451
22Osteolytic defects of the hand bones (HP:0009699)2.60680143
23Osteolytic defects of the phalanges of the hand (HP:0009771)2.60680143
24Soft skin (HP:0000977)2.57706146
25Coronal craniosynostosis (HP:0004440)2.52361105
26Neonatal short-limb short stature (HP:0008921)2.52272142
27Peritonitis (HP:0002586)2.51815762
28Wrist flexion contracture (HP:0001239)2.48891357
29Bowel diverticulosis (HP:0005222)2.42330039
30Natal tooth (HP:0000695)2.39160963
31Abnormality of dentin (HP:0010299)2.38865233
32Abnormality of the distal phalanx of the thumb (HP:0009617)2.33334805
33Wormian bones (HP:0002645)2.31635982
34Fragile nails (HP:0001808)2.31238948
35Blue sclerae (HP:0000592)2.30151811
36Ankyloglossia (HP:0010296)2.28957314
37Ulnar bowing (HP:0003031)2.27992162
38Onycholysis (HP:0001806)2.26966352
39Pterygium (HP:0001059)2.22295935
40Broad thumb (HP:0011304)2.21414554
41Deviation of the hallux (HP:0010051)2.20788037
42Hyperacusis (HP:0010780)2.20695121
43Alopecia of scalp (HP:0002293)2.20186908
44Flat acetabular roof (HP:0003180)2.20037046
45Tibial bowing (HP:0002982)2.16191748
46Buphthalmos (HP:0000557)2.14976874
47Wide anterior fontanel (HP:0000260)2.13985492
48Broad long bones (HP:0005622)2.13268834
49Abnormality of oral frenula (HP:0000190)2.13102066
50Mitral stenosis (HP:0001718)2.12583331
51Radial bowing (HP:0002986)2.12385787
52Aneurysm (HP:0002617)2.11870159
53Mesomelia (HP:0003027)2.09867661
54Hypoplastic ischia (HP:0003175)2.09109836
55Hallux valgus (HP:0001822)2.08167248
56Plantar hyperkeratosis (HP:0007556)2.08139645
57Abnormality of nail color (HP:0100643)2.07422518
58Insomnia (HP:0100785)2.06334204
59Abnormal ossification of hand bones (HP:0005921)2.05664287
60Abnormality of carpal bone ossification (HP:0006257)2.05192944
61Overgrowth (HP:0001548)2.03293104
62Turricephaly (HP:0000262)2.00608822
63Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.00380272
64Right ventricular cardiomyopathy (HP:0011663)2.00154012
65Advanced eruption of teeth (HP:0006288)1.99081107
66Hyperextensible skin (HP:0000974)1.97414965
67Selective tooth agenesis (HP:0001592)1.96218910
68Broad phalanx (HP:0006009)1.95359563
69Increased connective tissue (HP:0009025)1.92644498
70Broad phalanges of the hand (HP:0009768)1.92441815
71Bowed forearm bones (HP:0003956)1.89991181
72Bowing of the arm (HP:0006488)1.89991181
73Joint laxity (HP:0001388)1.89832705
74Broad ribs (HP:0000885)1.89032402
75Spinal rigidity (HP:0003306)1.88704037
76Missing ribs (HP:0000921)1.88562240
77Bell-shaped thorax (HP:0001591)1.87742008
78Broad finger (HP:0001500)1.87451292
79Thin bony cortex (HP:0002753)1.86896762
80Bronchomalacia (HP:0002780)1.85142107
81Mitral regurgitation (HP:0001653)1.84657497
82Abnormality of the ischium (HP:0003174)1.83259132
83Follicular hyperkeratosis (HP:0007502)1.82624091
84Deviation of the thumb (HP:0009603)1.81612238
85Short nail (HP:0001799)1.79247991
86Broad face (HP:0000283)1.77462907
87Synostosis of carpal bones (HP:0005048)1.77388092
88Cardiovascular calcification (HP:0011915)1.76216665
89Abnormality of the nasal septum (HP:0000419)1.76080673
90Camptodactyly of toe (HP:0001836)1.75985960
91Renovascular hypertension (HP:0100817)1.75776089
92Aplasia cutis congenita (HP:0001057)1.75769646
93Infantile muscular hypotonia (HP:0008947)1.74856450
94Renal duplication (HP:0000075)1.73754235
95Upper limb amyotrophy (HP:0009129)1.72697648
96Distal upper limb amyotrophy (HP:0007149)1.72697648
97Thick nail (HP:0001805)1.72533010
98Abnormality of the acetabulum (HP:0003170)1.71976574
99Ridged nail (HP:0001807)1.71855178
100Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71645333
101Mildly elevated creatine phosphokinase (HP:0008180)1.71185133
102Arnold-Chiari malformation (HP:0002308)1.71111666
103Hip contracture (HP:0003273)1.70676572
104Spondylolisthesis (HP:0003302)1.70304458
105Abnormal hand bone ossification (HP:0010660)1.70205920
106Knee flexion contracture (HP:0006380)1.70189706
107Trigonocephaly (HP:0000243)1.69713327
108Abnormality of the astrocytes (HP:0100707)1.69400860
109Astrocytoma (HP:0009592)1.69400860
110Hypoplastic labia majora (HP:0000059)1.68618316
111Tarsal synostosis (HP:0008368)1.67326516
112Microglossia (HP:0000171)1.67070205
113Abnormality of the distal phalanges of the toes (HP:0010182)1.66731279
114Lymphangioma (HP:0100764)1.66688708
115Short humerus (HP:0005792)1.66309509
116Vascular tortuosity (HP:0004948)1.66014263
117Narrow palate (HP:0000189)1.65939485
118Subacute progressive viral hepatitis (HP:0006572)1.65402307
119Aplasia involving bones of the extremities (HP:0009825)1.65066311
120Aplasia involving bones of the upper limbs (HP:0009823)1.65066311
121Aplasia of the phalanges of the hand (HP:0009802)1.65066311
122Abnormal vertebral ossification (HP:0100569)1.64358132
123Increased density of long bones (HP:0006392)1.64183627
124Protruding ear (HP:0000411)1.64002934
125Type 1 muscle fiber predominance (HP:0003803)1.63907123
126Elbow flexion contracture (HP:0002987)1.63303113
127Abnormality of the calcaneus (HP:0008364)1.62907964
128Scapular winging (HP:0003691)1.62871062
129Fused cervical vertebrae (HP:0002949)1.62831568
130Midface retrusion (HP:0011800)1.62256584
131Abnormality of the peritoneum (HP:0002585)1.61903486
132Congenital glaucoma (HP:0001087)1.61585532
133Abnormal delivery (HP:0001787)1.61096662
134Hypoplasia of the maxilla (HP:0000327)1.61054469
135Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.60948701
136Broad toe (HP:0001837)1.60888063
137Limited elbow extension (HP:0001377)1.60552321
138Absent frontal sinuses (HP:0002688)1.59993393
139Syringomyelia (HP:0003396)1.59068145
140Spinal cord lesions (HP:0100561)1.59068145
141Abnormality of the proximal phalanges of the hand (HP:0009834)1.58700255
142Aortic regurgitation (HP:0001659)1.58596307
143Abnormality of the gastric mucosa (HP:0004295)1.57999559
144Relative macrocephaly (HP:0004482)1.57719112
145Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.55970614
146Hypoplasia of dental enamel (HP:0006297)1.55076335
147Abnormal foot bone ossification (HP:0010675)1.54663622
148Elfin facies (HP:0004428)1.53899651
149Flat cornea (HP:0007720)1.53407994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.38207517
2EPHA23.65735990
3DDR23.54052751
4CDK123.53959934
5TTN3.26574300
6PDGFRA2.77413240
7SIK12.76310434
8RIPK12.50932993
9EPHB22.45794743
10STK392.24757339
11LATS22.21493171
12TRIB32.07939647
13PKN21.69220005
14PTK21.68747872
15MET1.67177981
16MTOR1.65512258
17FGFR21.65495525
18FRK1.63388452
19EPHA31.62984747
20PBK1.58704788
21PAK21.57066483
22CAMK1D1.54935739
23FER1.53711764
24STK31.53242997
25PTK61.52572487
26FGFR11.50193814
27BMX1.47883089
28ICK1.47332767
29PAK41.44300284
30SCYL21.37137425
31DMPK1.35457354
32BRD41.35124097
33MYLK1.33175588
34WNK41.33115396
35NEK91.29605829
36EEF2K1.26244634
37CAMK1G1.24968967
38PAK31.19699296
39STK38L1.17238759
40MAP3K101.14051435
41PDGFRB1.13019606
42TSSK61.07138955
43TYRO31.01769087
44MST41.00963375
45NTRK10.99325434
46KSR10.97281567
47CDK60.95217337
48ERBB20.92991532
49PNCK0.91570952
50ROCK10.88943847
51LMTK20.87060950
52SMG10.85740418
53FGFR40.84492536
54RPS6KB20.81531855
55TTK0.80725301
56ERBB40.80602545
57PIK3CA0.78654066
58CDC70.78589096
59NUAK10.75749288
60BCR0.75491687
61WNK10.74622149
62PRKD30.74373326
63STK240.73265517
64PIM20.72005426
65LRRK20.68812633
66CDC42BPA0.65811605
67ALK0.64959871
68CDK70.62898107
69EPHB10.61252678
70NEK20.61075514
71TESK10.60259671
72ERN10.57837088
73ROCK20.57338068
74BRSK20.56127814
75TRPM70.55694180
76NEK10.54980957
77MAP3K80.53785151
78INSR0.51871686
79RET0.51551427
80TNIK0.51535926
81MAP3K60.48343826
82CHEK10.47979096
83STK380.47768315
84MAP3K20.47619327
85MELK0.47517528
86CHEK20.46783271
87DYRK1B0.46396322
88FLT30.46033872
89CSNK1A1L0.45719156
90FGFR30.45580260
91CASK0.45291563
92AURKB0.44486590
93STK100.44087923
94MST1R0.43551749
95ZAK0.43469921
96CSNK1D0.43147602
97MAPK10.42209413
98PAK60.41926079
99ATM0.41891905
100PRKDC0.40683439
101MAP3K90.40379948
102CSNK1E0.39753850
103CDK80.39335632
104PRKG20.39106540
105PLK30.38812241
106LIMK10.38794776
107AKT30.38652237
108CDK90.38617469
109AKT20.38516156
110SRC0.37523488
111GSK3A0.36512951
112ERBB30.34587660
113CHUK0.34579421
114MAP3K120.33679534
115CDK40.33455105
116PRKCI0.33229883
117CDK20.32736854
118NEK60.32470511
119ATR0.31783750
120TGFBR10.31510483
121CDK10.31363949
122ABL20.30088212
123EIF2AK30.30048346
124AKT10.29061303
125RPS6KA20.28417222
126PRKD20.27860594
127TAF10.27390702
128SGK30.27192194
129EIF2AK10.26211142
130PLK10.24600192
131TGFBR20.24513587
132MAPK100.22949999
133MKNK10.22460328

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.55975364
2Basal cell carcinoma_Homo sapiens_hsa052172.96971779
3Adherens junction_Homo sapiens_hsa045202.72480901
4Hippo signaling pathway_Homo sapiens_hsa043902.69113158
5Focal adhesion_Homo sapiens_hsa045102.62782566
6Proteoglycans in cancer_Homo sapiens_hsa052052.34302297
7Hedgehog signaling pathway_Homo sapiens_hsa043402.30424068
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.25266503
9MicroRNAs in cancer_Homo sapiens_hsa052062.17469787
10TGF-beta signaling pathway_Homo sapiens_hsa043502.10603321
11Protein digestion and absorption_Homo sapiens_hsa049742.08769752
12Bladder cancer_Homo sapiens_hsa052192.07022146
13Small cell lung cancer_Homo sapiens_hsa052222.05505454
14Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.94879461
15Tight junction_Homo sapiens_hsa045301.86581018
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.84762953
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70116881
18Amoebiasis_Homo sapiens_hsa051461.69612341
19Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59294221
20Dilated cardiomyopathy_Homo sapiens_hsa054141.57952059
21Wnt signaling pathway_Homo sapiens_hsa043101.53869202
22Axon guidance_Homo sapiens_hsa043601.50253730
23Lysine degradation_Homo sapiens_hsa003101.39135291
24Chronic myeloid leukemia_Homo sapiens_hsa052201.36690122
25Melanoma_Homo sapiens_hsa052181.33285815
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.29262302
27Endometrial cancer_Homo sapiens_hsa052131.28862858
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25581743
29p53 signaling pathway_Homo sapiens_hsa041151.25204773
30Regulation of actin cytoskeleton_Homo sapiens_hsa048101.25066818
31Pathways in cancer_Homo sapiens_hsa052001.24503708
32Prostate cancer_Homo sapiens_hsa052151.24415946
33Melanogenesis_Homo sapiens_hsa049161.23869516
34Notch signaling pathway_Homo sapiens_hsa043301.23671506
35Glioma_Homo sapiens_hsa052141.17452220
36mTOR signaling pathway_Homo sapiens_hsa041501.14585691
37Viral myocarditis_Homo sapiens_hsa054161.12269702
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10977225
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.08407946
40Colorectal cancer_Homo sapiens_hsa052101.07050539
41Renin-angiotensin system_Homo sapiens_hsa046141.05928752
42Thyroid hormone signaling pathway_Homo sapiens_hsa049191.05511964
43Rap1 signaling pathway_Homo sapiens_hsa040150.99616656
44Leukocyte transendothelial migration_Homo sapiens_hsa046700.96891113
45Cell cycle_Homo sapiens_hsa041100.96674301
46Pancreatic cancer_Homo sapiens_hsa052120.93316956
47Dorso-ventral axis formation_Homo sapiens_hsa043200.92938949
48HTLV-I infection_Homo sapiens_hsa051660.91799251
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90639865
50Vitamin B6 metabolism_Homo sapiens_hsa007500.88840745
51Renal cell carcinoma_Homo sapiens_hsa052110.87896127
52Non-homologous end-joining_Homo sapiens_hsa034500.87567316
53Nitrogen metabolism_Homo sapiens_hsa009100.87362379
54Estrogen signaling pathway_Homo sapiens_hsa049150.86629834
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.85671311
56Viral carcinogenesis_Homo sapiens_hsa052030.84494996
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82829951
58Thyroid cancer_Homo sapiens_hsa052160.82749339
59Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79296874
60N-Glycan biosynthesis_Homo sapiens_hsa005100.78655304
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75725793
62ErbB signaling pathway_Homo sapiens_hsa040120.75666921
63Inositol phosphate metabolism_Homo sapiens_hsa005620.75413619
64Gap junction_Homo sapiens_hsa045400.74411431
65Thyroid hormone synthesis_Homo sapiens_hsa049180.73461380
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73211501
67AMPK signaling pathway_Homo sapiens_hsa041520.72565989
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71353259
69Prion diseases_Homo sapiens_hsa050200.69421682
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66780165
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65536007
72Mineral absorption_Homo sapiens_hsa049780.65488920
73Non-small cell lung cancer_Homo sapiens_hsa052230.65248872
74Sphingolipid metabolism_Homo sapiens_hsa006000.64522621
75Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64070378
76Systemic lupus erythematosus_Homo sapiens_hsa053220.62806177
77Insulin resistance_Homo sapiens_hsa049310.61923291
78FoxO signaling pathway_Homo sapiens_hsa040680.61444247
79Bile secretion_Homo sapiens_hsa049760.59636195
80mRNA surveillance pathway_Homo sapiens_hsa030150.58268351
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58237156
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.55472984
83Arginine biosynthesis_Homo sapiens_hsa002200.55057789
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54833409
85Type II diabetes mellitus_Homo sapiens_hsa049300.52534213
86One carbon pool by folate_Homo sapiens_hsa006700.52333826
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52013313
88Glucagon signaling pathway_Homo sapiens_hsa049220.50801079
89Fatty acid biosynthesis_Homo sapiens_hsa000610.50502532
90RNA transport_Homo sapiens_hsa030130.50421613
91Insulin signaling pathway_Homo sapiens_hsa049100.50363534
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49618794
93Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49091368
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.48926773
95Platelet activation_Homo sapiens_hsa046110.48214998
96Toxoplasmosis_Homo sapiens_hsa051450.47480122
97cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47259401
98Galactose metabolism_Homo sapiens_hsa000520.46123243
99HIF-1 signaling pathway_Homo sapiens_hsa040660.44849702
100GnRH signaling pathway_Homo sapiens_hsa049120.44839556
101Oocyte meiosis_Homo sapiens_hsa041140.44811885
102Ovarian steroidogenesis_Homo sapiens_hsa049130.44608433
103Biosynthesis of amino acids_Homo sapiens_hsa012300.43023412
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41840387
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41435150
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40136769
107Ras signaling pathway_Homo sapiens_hsa040140.40007553
108Fat digestion and absorption_Homo sapiens_hsa049750.39667999
109Alcoholism_Homo sapiens_hsa050340.39590633
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.39156220
111Endocytosis_Homo sapiens_hsa041440.38536173
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38029445
113MAPK signaling pathway_Homo sapiens_hsa040100.38026136
114Choline metabolism in cancer_Homo sapiens_hsa052310.37801850
115Complement and coagulation cascades_Homo sapiens_hsa046100.37351443
116Steroid biosynthesis_Homo sapiens_hsa001000.37169498
117Starch and sucrose metabolism_Homo sapiens_hsa005000.37023387
118Circadian rhythm_Homo sapiens_hsa047100.34502708
119Prolactin signaling pathway_Homo sapiens_hsa049170.31827734
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31663277

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