FATE1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gonadotropin secretion (GO:0032276)9.31388424
2SMAD protein signal transduction (GO:0060395)9.11542093
3regulation of male gonad development (GO:2000018)9.04982776
4negative regulation of macrophage differentiation (GO:0045650)9.03507413
5mesenchymal to epithelial transition (GO:0060231)8.86558364
6melanin biosynthetic process (GO:0042438)8.81823407
7cellular response to follicle-stimulating hormone stimulus (GO:0071372)8.62281870
8negative regulation of kidney development (GO:0090185)8.24920053
9melanin metabolic process (GO:0006582)7.99279124
10secondary metabolite biosynthetic process (GO:0044550)7.74526654
11gonadal mesoderm development (GO:0007506)7.29792826
12centriole replication (GO:0007099)7.29412695
13cellular response to gonadotropin stimulus (GO:0071371)6.98822790
14fusion of sperm to egg plasma membrane (GO:0007342)6.69769335
15anatomical structure regression (GO:0060033)6.67850833
16response to follicle-stimulating hormone (GO:0032354)6.59415348
17sex differentiation (GO:0007548)6.52155136
18sex determination (GO:0007530)6.37650562
19male sex determination (GO:0030238)6.24474614
20sensory perception of chemical stimulus (GO:0007606)6.14287039
21hemoglobin metabolic process (GO:0020027)6.06669880
22nephron tubule formation (GO:0072079)5.80143663
23response to gonadotropin (GO:0034698)5.79082989
24centriole assembly (GO:0098534)5.75295021
25regulation of metanephros development (GO:0072215)5.70188601
26attachment of spindle microtubules to kinetochore (GO:0008608)5.52754057
27cytoplasmic mRNA processing body assembly (GO:0033962)5.35114649
28seminiferous tubule development (GO:0072520)5.26446964
29endocardial cushion development (GO:0003197)5.18089068
30histone H2B ubiquitination (GO:0033523)5.15830891
31response to interleukin-6 (GO:0070741)5.07590408
32positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)5.04662367
33short-chain fatty acid metabolic process (GO:0046459)5.03916240
34plasma membrane fusion (GO:0045026)5.03607762
35protein insertion into membrane (GO:0051205)4.85810948
36ventricular system development (GO:0021591)4.81709798
37cornea development in camera-type eye (GO:0061303)4.78584567
38regulation of meiosis (GO:0040020)4.77086117
39regulation of cardioblast differentiation (GO:0051890)4.74496776
40embryonic axis specification (GO:0000578)4.73922657
41protein localization to cilium (GO:0061512)4.63100407
42epithelial cell fate commitment (GO:0072148)4.57926169
43axonemal dynein complex assembly (GO:0070286)4.50467474
44Leydig cell differentiation (GO:0033327)4.48822288
45cardiac muscle adaptation (GO:0014887)4.47540022
46cardiac muscle hypertrophy in response to stress (GO:0014898)4.47540022
47muscle hypertrophy in response to stress (GO:0003299)4.47540022
48metanephros development (GO:0001656)4.45703540
49anterior/posterior axis specification, embryo (GO:0008595)4.44385550
50atrioventricular valve morphogenesis (GO:0003181)4.41743739
51branching involved in ureteric bud morphogenesis (GO:0001658)4.33031346
52positive regulation of odontogenesis (GO:0042482)4.29263805
53muscle cell fate commitment (GO:0042693)4.26848149
54melanocyte differentiation (GO:0030318)4.22387562
55cardiac right ventricle morphogenesis (GO:0003215)4.18652571
56male gonad development (GO:0008584)4.17606910
57columnar/cuboidal epithelial cell differentiation (GO:0002065)4.17230569
58skeletal muscle organ development (GO:0060538)4.14513959
59male genitalia development (GO:0030539)4.13908944
60response to BMP (GO:0071772)4.12997017
61cellular response to BMP stimulus (GO:0071773)4.12997017
62diaphragm development (GO:0060539)4.08994800
63glomerulus development (GO:0032835)4.08974509
64negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.08920343
65negative regulation of meiotic cell cycle (GO:0051447)3.96220250
66activation of protein kinase A activity (GO:0034199)3.93172130
67cilium movement (GO:0003341)3.92921456
68placenta development (GO:0001890)3.90270343
69embryonic foregut morphogenesis (GO:0048617)3.87878659
70female gamete generation (GO:0007292)3.84293626
71regulation of DNA methylation (GO:0044030)3.82736128
72regulation of meiotic cell cycle (GO:0051445)3.82731010
73pigment cell differentiation (GO:0050931)3.77808027
74mitotic metaphase plate congression (GO:0007080)3.77275586
75fibroblast migration (GO:0010761)3.76859440
76regulation of cardiac muscle cell contraction (GO:0086004)3.75949727
77startle response (GO:0001964)3.75704955
78short-term memory (GO:0007614)3.75560914
79regulation of interferon-gamma biosynthetic process (GO:0045072)3.75233350
80meiotic cell cycle (GO:0051321)3.75151534
81metanephric mesenchyme development (GO:0072075)3.74228609
82regulation of sister chromatid cohesion (GO:0007063)3.71554975
83DNA damage induced protein phosphorylation (GO:0006975)3.68158513
84atrial septum morphogenesis (GO:0060413)3.68098452
85ovulation cycle (GO:0042698)3.68058312
86adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.62922300
87aggressive behavior (GO:0002118)3.62606549
88glycerophospholipid catabolic process (GO:0046475)3.62056323
89protein-chromophore linkage (GO:0018298)3.61481128
90positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58264615
91positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58264615
92positive regulation of mitotic sister chromatid separation (GO:1901970)3.58264615
93RNA destabilization (GO:0050779)3.56348826
94regulation of steroid hormone secretion (GO:2000831)3.53162013
95otic vesicle formation (GO:0030916)3.50709361
96mesonephros development (GO:0001823)3.45807599
97neuron cell-cell adhesion (GO:0007158)3.33869440
98purine nucleotide salvage (GO:0032261)3.33307341
99cardiac muscle hypertrophy (GO:0003300)3.33234162
100gonad development (GO:0008406)3.31957198
101reproductive system development (GO:0061458)3.29839690
102epithelial cell morphogenesis (GO:0003382)3.28519058
103mitotic chromosome condensation (GO:0007076)3.27907746
104kidney mesenchyme development (GO:0072074)3.27001802
105response to pheromone (GO:0019236)3.24016374
106androgen biosynthetic process (GO:0006702)3.21341423
107lipopolysaccharide biosynthetic process (GO:0009103)3.21209976
108regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.19346143
109neuroepithelial cell differentiation (GO:0060563)3.17575929
110phenol-containing compound biosynthetic process (GO:0046189)3.17299861
111regulation of glomerulus development (GO:0090192)3.16203922
112negative regulation of osteoblast differentiation (GO:0045668)3.15691531
113negative regulation of circadian rhythm (GO:0042754)3.15604322
114negative regulation of meiosis (GO:0045835)3.14480757
115regulation of macrophage differentiation (GO:0045649)3.13647767
116striated muscle hypertrophy (GO:0014897)3.13519769
117regulation of mesenchymal cell apoptotic process (GO:2001053)3.12570079
118regulation of cell proliferation involved in kidney development (GO:1901722)3.12325407
119negative regulation of epithelial cell differentiation (GO:0030857)3.11391921
120negative regulation of reproductive process (GO:2000242)3.10970775
121regulation of RIG-I signaling pathway (GO:0039535)3.10540894
122virion attachment to host cell (GO:0019062)3.08853147
123adhesion of symbiont to host cell (GO:0044650)3.08853147
124neuronal action potential propagation (GO:0019227)3.07122257
125metaphase plate congression (GO:0051310)3.06653532
126positive regulation of megakaryocyte differentiation (GO:0045654)3.05745831
127production of molecular mediator involved in inflammatory response (GO:0002532)3.04321784
128regulation of synaptic vesicle transport (GO:1902803)3.04258453
129phosphorelay signal transduction system (GO:0000160)3.03958885
130left/right axis specification (GO:0070986)3.00873501
131glutathione derivative biosynthetic process (GO:1901687)3.00754235
132glutathione derivative metabolic process (GO:1901685)3.00754235
133positive regulation of heart growth (GO:0060421)2.99360596
134negative regulation of activin receptor signaling pathway (GO:0032926)2.98242913
135negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.96511748
136urogenital system development (GO:0001655)2.96494101
137response to caffeine (GO:0031000)2.95549585
138notochord development (GO:0030903)2.92833045
139regulation of actin filament-based movement (GO:1903115)2.91965160
140regulation of female receptivity (GO:0045924)2.90362157
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.89814171
142negative regulation of T-helper cell differentiation (GO:0045623)2.89814171
143positive regulation of chromosome segregation (GO:0051984)2.89314215
144regulation of meiosis I (GO:0060631)2.89054881
145regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.88029744
146regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.88029744
147protein polyglutamylation (GO:0018095)2.87513008
148regulation of synaptic vesicle exocytosis (GO:2000300)2.87359412
149establishment of spindle localization (GO:0051293)2.86615152
150dentate gyrus development (GO:0021542)2.86295043
151microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.85955444
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84865471
153piRNA metabolic process (GO:0034587)2.83992771
154potassium ion export (GO:0071435)2.82952790
155centrosome duplication (GO:0051298)2.80096049
156histone H2A ubiquitination (GO:0033522)2.80001292
157olfactory bulb development (GO:0021772)2.79170285
158regulation of autophagic vacuole assembly (GO:2000785)2.76017846
159magnesium ion transport (GO:0015693)2.74679792
160positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74047635
161synaptic vesicle exocytosis (GO:0016079)2.72522342
162adipose tissue development (GO:0060612)2.68368919
163cAMP biosynthetic process (GO:0006171)2.66395493
164eye photoreceptor cell differentiation (GO:0001754)2.65102575
165photoreceptor cell differentiation (GO:0046530)2.65102575
166protein monoubiquitination (GO:0006513)2.64353428
167microtubule severing (GO:0051013)2.60702573
168negative regulation of homotypic cell-cell adhesion (GO:0034111)2.60652654
169regulation of exit from mitosis (GO:0007096)2.59193720
170positive regulation of meiosis (GO:0045836)2.58826611
171central nervous system myelination (GO:0022010)2.58822732
172axon ensheathment in central nervous system (GO:0032291)2.58822732
173cilium morphogenesis (GO:0060271)2.58712761
174glutamate secretion (GO:0014047)2.57110548
175regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.56219363
176regulation of neurotransmitter uptake (GO:0051580)2.53582926
177regulation of histone H3-K27 methylation (GO:0061085)2.52771389
178protein K48-linked ubiquitination (GO:0070936)2.52749574
179DNA ligation (GO:0006266)2.52165017
180intraciliary transport (GO:0042073)2.51872702
181protein autoubiquitination (GO:0051865)2.50531772
182protein localization to synapse (GO:0035418)2.49566613
183oocyte maturation (GO:0001556)2.46864410
184membrane tubulation (GO:0097320)2.46812387
185regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.45238182
186establishment of chromosome localization (GO:0051303)2.44364221
187sister chromatid cohesion (GO:0007062)2.43714208
188female mating behavior (GO:0060180)2.43557636
189positive regulation of meiotic cell cycle (GO:0051446)2.42746651
190negative regulation of metanephros development (GO:0072217)15.1109416
191response to parathyroid hormone (GO:0071107)12.9279070
192regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:000333912.2879200
193positive regulation of male gonad development (GO:2000020)11.4293818
194sensory perception of smell (GO:0007608)11.0343520
195labyrinthine layer development (GO:0060711)10.9332646
196regulation of female gonad development (GO:2000194)10.2263598

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.45516783
2EZH2_22144423_ChIP-Seq_EOC_Human4.73574091
3ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse4.57404138
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.29913491
5CHD7_19251738_ChIP-ChIP_MESCs_Mouse3.81218008
6GBX2_23144817_ChIP-Seq_PC3_Human3.63038333
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.58788609
8STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.40456765
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.19644830
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.50253923
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.29033741
12CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26056285
13TAF15_26573619_Chip-Seq_HEK293_Human2.18571538
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.14528602
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10002833
16PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09548850
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08933192
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.07789165
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.06222891
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.05995477
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.03364130
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.02813388
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00971952
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00856016
25RNF2_27304074_Chip-Seq_NSC_Mouse2.00125935
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91298386
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.86681651
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.83338365
29EZH2_18974828_ChIP-Seq_MESCs_Mouse1.83338365
30MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.81333951
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80990770
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.80897082
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.79879050
34SMAD4_21799915_ChIP-Seq_A2780_Human1.76591378
35SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.76116183
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75623336
37P300_19829295_ChIP-Seq_ESCs_Human1.75516800
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74009197
39GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.72392433
40EST1_17652178_ChIP-ChIP_JURKAT_Human1.71722118
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70114143
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.67705285
43LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65256196
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.63869765
45FUS_26573619_Chip-Seq_HEK293_Human1.63432559
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.61834618
47SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61730973
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59917913
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.58780556
50CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.57264172
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57005292
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55565369
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54560535
54SMAD4_21741376_ChIP-Seq_EPCs_Human1.54334414
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.52394492
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52183501
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51667117
58SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.49571319
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.49182227
60POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48188269
61IGF1R_20145208_ChIP-Seq_DFB_Human1.47797319
62E2F1_17053090_ChIP-ChIP_MCF-7_Human1.46477110
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45433521
64SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43870323
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.43192912
66EZH2_27304074_Chip-Seq_ESCs_Mouse1.40694533
67STAT3_23295773_ChIP-Seq_U87_Human1.40542873
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39749685
69UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38794751
70RNF2_27304074_Chip-Seq_ESCs_Mouse1.37976099
71EWS_26573619_Chip-Seq_HEK293_Human1.37340155
72EOMES_21245162_ChIP-Seq_HESCs_Human1.37086814
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.36617608
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.35806665
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35394275
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34831672
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32867572
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.32266004
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31025969
80ZNF263_19887448_ChIP-Seq_K562_Human1.30445991
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30425095
82SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28728973
83TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28348724
84AR_25329375_ChIP-Seq_VCAP_Human1.28078659
85LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27118898
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26781645
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26139215
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.25905274
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25812042
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.25199716
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23410497
92TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23395450
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22852436
94REST_21632747_ChIP-Seq_MESCs_Mouse1.22571641
95GF1_26923725_Chip-Seq_HPCs_Mouse1.22544783
96AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21895567
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21713707
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21247365
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21247365
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.20013521
101CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18290887
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17865887
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17274632
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17222937
105JUN_21703547_ChIP-Seq_K562_Human1.16425846
106FLI1_27457419_Chip-Seq_LIVER_Mouse1.15884579
107ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15620139
108SUZ12_27294783_Chip-Seq_ESCs_Mouse1.15172746
109CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14583882
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14239005
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12999643
112THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12988951
113STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11047864
114KDM2B_26808549_Chip-Seq_REH_Human1.10979606
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10623280
116RUNX2_22187159_ChIP-Seq_PCA_Human1.10381990
117SMAD4_21741376_ChIP-Seq_HESCs_Human1.09374871
118FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07126566
119CDX2_20551321_ChIP-Seq_CACO-2_Human1.07078458
120CDX2_22108803_ChIP-Seq_LS180_Human1.04997271
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.04658895
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.04562619
123NANOG_18555785_Chip-Seq_ESCs_Mouse1.04358047
124PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04319515
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03971385
126GATA1_19941826_ChIP-Seq_K562_Human1.03628232
127EZH2_27294783_Chip-Seq_ESCs_Mouse1.03544903
128SOX2_21211035_ChIP-Seq_LN229_Gbm1.03532561
129KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02899781
130AR_21572438_ChIP-Seq_LNCaP_Human1.02637128
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.01539388
132PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01227956
133SMAD3_21741376_ChIP-Seq_ESCs_Human1.00951726
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00767809
135MYC_18940864_ChIP-ChIP_HL60_Human1.00109156
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99660807
137TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99601492
138EP300_21415370_ChIP-Seq_HL-1_Mouse0.99475206
139TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99466485
140ER_23166858_ChIP-Seq_MCF-7_Human0.99305099
141POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.98963131
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98748962
143JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.98731271
144CBX2_27304074_Chip-Seq_ESCs_Mouse0.98426809
145YY1_22570637_ChIP-Seq_MALME-3M_Human0.98099111
146GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96808438
147PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95411545
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.94735562
149PPARA_22158963_ChIP-Seq_LIVER_Mouse0.93577735
150PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91375168
151RXR_22158963_ChIP-Seq_LIVER_Mouse0.90920000
152RARB_24833708_ChIP-Seq_LIVER_Mouse0.88171098
153MYC_18555785_ChIP-Seq_MESCs_Mouse0.87521670
154CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.87293541
155REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85058461
156TP53_22573176_ChIP-Seq_HFKS_Human0.83829025
157SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.82251091
158RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.82029900
159CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.80932451
160FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.80331029
161WDR5_24793694_ChIP-Seq_LNCAP_Human0.79944494
162TP53_20018659_ChIP-ChIP_R1E_Mouse0.79715396
163GABP_17652178_ChIP-ChIP_JURKAT_Human0.78898747
164VDR_23849224_ChIP-Seq_CD4+_Human0.78222732
165NOTCH1_21737748_ChIP-Seq_TLL_Human0.76964247
166SMAD1_18555785_Chip-Seq_ESCs_Mouse0.76546323
167FLI1_21867929_ChIP-Seq_CD8_Mouse0.76407226

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008995_early_reproductive_senescence6.47863990
2MP0000537_abnormal_urethra_morphology5.53136178
3MP0003315_abnormal_perineum_morphology5.33896735
4MP0001661_extended_life_span4.17825882
5MP0005451_abnormal_body_composition4.01460447
6MP0003718_maternal_effect3.91811005
7MP0003828_pulmonary_edema3.41994054
8MP0009384_cardiac_valve_regurgitation3.25387792
9MP0003183_abnormal_peptide_metabolism3.19615021
10MP0004859_abnormal_synaptic_plasticity3.06898903
11MP0003646_muscle_fatigue2.74596233
12MP0002160_abnormal_reproductive_system2.63797303
13MP0003786_premature_aging2.63195301
14MP0000639_abnormal_adrenal_gland2.60901312
15MP0002102_abnormal_ear_morphology2.53956330
16MP0001529_abnormal_vocalization2.42552851
17MP0001485_abnormal_pinna_reflex2.40862296
18MP0002653_abnormal_ependyma_morphology2.34877907
19MP0009697_abnormal_copulation2.14899757
20MP0001905_abnormal_dopamine_level2.04611539
21MP0005389_reproductive_system_phenotype2.04352447
22MP0005646_abnormal_pituitary_gland2.00662423
23MP0001984_abnormal_olfaction11.5843957
24MP0006276_abnormal_autonomic_nervous1.97095084
25MP0003787_abnormal_imprinting1.96507738
26MP0004270_analgesia1.90859592
27MP0003567_abnormal_fetal_cardiomyocyte1.88966063
28MP0008877_abnormal_DNA_methylation1.88346432
29MP0001727_abnormal_embryo_implantation1.80632325
30MP0002184_abnormal_innervation1.77943401
31MP0003635_abnormal_synaptic_transmissio1.75952246
32MP0002734_abnormal_mechanical_nocicepti1.75384389
33MP0002249_abnormal_larynx_morphology1.71521994
34MP0002876_abnormal_thyroid_physiology1.70606586
35MP0009672_abnormal_birth_weight1.69460359
36MP0005058_abnormal_lysosome_morphology1.67454378
37MP0003123_paternal_imprinting1.59161426
38MP0001119_abnormal_female_reproductive1.54549876
39MP0003699_abnormal_female_reproductive1.48936925
40MP0005395_other_phenotype1.48935042
41MP0002272_abnormal_nervous_system1.42503798
42MP0006138_congestive_heart_failure1.41329693
43MP0003942_abnormal_urinary_system1.32689655
44MP0000049_abnormal_middle_ear1.29554815
45MP0001486_abnormal_startle_reflex1.28892456
46MP0001145_abnormal_male_reproductive1.28413418
47MP0002063_abnormal_learning/memory/cond1.26888047
48MP0005367_renal/urinary_system_phenotyp1.25037779
49MP0000516_abnormal_urinary_system1.25037779
50MP0003119_abnormal_digestive_system1.22153463
51MP0004145_abnormal_muscle_electrophysio1.18204261
52MP0001849_ear_inflammation1.18004015
53MP0008789_abnormal_olfactory_epithelium1.17003408
54MP0000631_abnormal_neuroendocrine_gland1.15269660
55MP0003937_abnormal_limbs/digits/tail_de1.13592420
56MP0005394_taste/olfaction_phenotype1.12897329
57MP0005499_abnormal_olfactory_system1.12897329
58MP0002638_abnormal_pupillary_reflex1.12208022
59MP0002752_abnormal_somatic_nervous1.09391896
60MP0002572_abnormal_emotion/affect_behav1.08393627
61MP0001919_abnormal_reproductive_system1.07075077
62MP0003121_genomic_imprinting1.06452349
63MP0003115_abnormal_respiratory_system1.03520999
64MP0002882_abnormal_neuron_morphology1.00236025
65MP0000778_abnormal_nervous_system0.98550405
66MP0003195_calcinosis0.98385336
67MP0009250_abnormal_appendicular_skeleto0.98363966
68MP0010234_abnormal_vibrissa_follicle0.98339595
69MP0004924_abnormal_behavior0.97833683
70MP0005386_behavior/neurological_phenoty0.97833683
71MP0004134_abnormal_chest_morphology0.97514586
72MP0001542_abnormal_bone_strength0.95261174
73MP0009333_abnormal_splenocyte_physiolog0.94836408
74MP0002210_abnormal_sex_determination0.93584399
75MP0000653_abnormal_sex_gland0.92929645
76MP0003186_abnormal_redox_activity0.91987672
77MP0002877_abnormal_melanocyte_morpholog0.90590578
78MP0002332_abnormal_exercise_endurance0.90554631
79MP0002557_abnormal_social/conspecific_i0.89353974
80MP0004484_altered_response_of0.87595973
81MP0009703_decreased_birth_body0.86869269
82MP0003698_abnormal_male_reproductive0.86772430
83MP0002067_abnormal_sensory_capabilities0.86253570
84MP0002009_preneoplasia0.85699399
85MP0001970_abnormal_pain_threshold0.84561275
86MP0005360_urolithiasis0.84477285
87MP0002127_abnormal_cardiovascular_syste0.83424731
88MP0001968_abnormal_touch/_nociception0.80572920
89MP0002152_abnormal_brain_morphology0.78244298
90MP0000579_abnormal_nail_morphology0.76808862
91MP0001929_abnormal_gametogenesis0.76089972
92MP0002064_seizures0.75267834
93MP0002161_abnormal_fertility/fecundity0.75087467
94MP0001963_abnormal_hearing_physiology0.74786799
95MP0002229_neurodegeneration0.73670088
96MP0004085_abnormal_heartbeat0.73535656
97MP0009745_abnormal_behavioral_response0.73426058
98MP0002233_abnormal_nose_morphology0.69969338
99MP0008007_abnormal_cellular_replicative0.67700173
100MP0005310_abnormal_salivary_gland0.67430366
101MP0002736_abnormal_nociception_after0.67362646
102MP0009765_abnormal_xenobiotic_induced0.66460499
103MP0001177_atelectasis0.64583196
104MP0004036_abnormal_muscle_relaxation0.64026488
105MP0001764_abnormal_homeostasis0.63572089
106MP0005423_abnormal_somatic_nervous0.63251826
107MP0005220_abnormal_exocrine_pancreas0.62418750
108MP0005410_abnormal_fertilization0.61612077
109MP0004215_abnormal_myocardial_fiber0.61611992
110MP0000026_abnormal_inner_ear0.61204493
111MP0002837_dystrophic_cardiac_calcinosis0.58609993
112MP0001188_hyperpigmentation0.58266521
113MP0003632_abnormal_nervous_system0.56489352
114MP0002295_abnormal_pulmonary_circulatio0.56153345
115MP0000462_abnormal_digestive_system0.54891721
116MP0002089_abnormal_postnatal_growth/wei0.54750062
117MP0001346_abnormal_lacrimal_gland0.54674629
118MP0000920_abnormal_myelination0.54588573
119MP0002133_abnormal_respiratory_system0.54504585
120MP0005388_respiratory_system_phenotype0.54504585
121MP0002128_abnormal_blood_circulation0.54079576
122MP0000678_abnormal_parathyroid_gland0.54064091
123MP0002114_abnormal_axial_skeleton0.53481102
124MP0003329_amyloid_beta_deposits0.53455155
125MP0000627_abnormal_mammary_gland0.53241932
126MP0000538_abnormal_urinary_bladder0.53065103
127MP0008875_abnormal_xenobiotic_pharmacok0.52982294
128MP0002066_abnormal_motor_capabilities/c0.52839529
129MP0004782_abnormal_surfactant_physiolog0.52760401
130MP0004885_abnormal_endolymph0.51715259
131MP0003137_abnormal_impulse_conducting0.51649175
132MP0003936_abnormal_reproductive_system0.50916563
133MP0000955_abnormal_spinal_cord0.50455183
134MP0005620_abnormal_muscle_contractility0.49895432
135MP0003806_abnormal_nucleotide_metabolis0.48912542
136MP0000013_abnormal_adipose_tissue0.48748453
137MP0005408_hypopigmentation0.48561440
138MP0010386_abnormal_urinary_bladder0.48325298
139MP0003755_abnormal_palate_morphology0.48114212
140MP0003656_abnormal_erythrocyte_physiolo0.48110014
141MP0009046_muscle_twitch0.48005510
142MP0008260_abnormal_autophagy0.47228510
143MP0005165_increased_susceptibility_to0.46909582
144MP0005508_abnormal_skeleton_morphology0.46819009
145MP0004133_heterotaxia0.44826515
146MP0000470_abnormal_stomach_morphology0.42904969
147MP0002909_abnormal_adrenal_gland0.41936850
148MP0003075_altered_response_to0.41455317
149MP0004019_abnormal_vitamin_homeostasis0.40904198
150MP0003122_maternal_imprinting0.39911488
151MP0001544_abnormal_cardiovascular_syste0.39357048
152MP0005385_cardiovascular_system_phenoty0.39357048
153MP0005197_abnormal_uvea_morphology0.38275135
154MP0000750_abnormal_muscle_regeneration0.37693863
155MP0002896_abnormal_bone_mineralization0.37409755
156MP0005647_abnormal_sex_gland0.36347237
157MP0002168_other_aberrant_phenotype0.34969922
158MP0010630_abnormal_cardiac_muscle0.34155704
159MP0004197_abnormal_fetal_growth/weight/0.33218482
160MP0000767_abnormal_smooth_muscle0.33010909
161MP0001440_abnormal_grooming_behavior0.32923529
162MP0005365_abnormal_bile_salt0.32043684
163MP0003011_delayed_dark_adaptation0.31037591
164MP0002106_abnormal_muscle_physiology0.30191170
165MP0005535_abnormal_body_temperature0.28515539
166MP0005257_abnormal_intraocular_pressure0.27474771
167MP0002135_abnormal_kidney_morphology0.26775507
168MP0000749_muscle_degeneration0.26264111
169MP0004043_abnormal_pH_regulation0.26081329
170MP0001502_abnormal_circadian_rhythm0.25827448
171MP0000467_abnormal_esophagus_morphology0.25520329
172MP0002084_abnormal_developmental_patter0.25500427
173MP0003221_abnormal_cardiomyocyte_apopto0.24846471
174MP0003953_abnormal_hormone_level0.24581474
175MP0003935_abnormal_craniofacial_develop0.24164246
176MP0003045_fibrosis0.23739823
177MP0000762_abnormal_tongue_morphology0.23570124

Predicted human phenotypes

RankGene SetZ-score
1Gonadal dysgenesis (HP:0000133)9.55381182
2Testicular neoplasm (HP:0010788)7.46223310
3Chronic bronchitis (HP:0004469)6.34380743
4Abnormal respiratory motile cilium physiology (HP:0012261)6.33663184
5Rhinitis (HP:0012384)5.80569573
6Hypoplastic left heart (HP:0004383)5.73457536
7Diaphragmatic weakness (HP:0009113)5.63746156
8Abnormality of male internal genitalia (HP:0000022)4.99154690
9Beaking of vertebral bodies (HP:0004568)4.90384943
10Stridor (HP:0010307)4.88873236
11Male infertility (HP:0003251)4.71205956
12Abnormality of macular pigmentation (HP:0008002)4.60681128
13Hypoplastic heart (HP:0001961)4.55940207
14Short nail (HP:0001799)4.40828122
15Molar tooth sign on MRI (HP:0002419)4.38850890
16Abnormality of midbrain morphology (HP:0002418)4.38850890
17Abnormal ventriculo-arterial connection (HP:0011563)4.25000029
18Transposition of the great arteries (HP:0001669)4.25000029
19Abnormal connection of the cardiac segments (HP:0011545)4.25000029
20Preauricular pit (HP:0004467)4.04420573
21Periauricular skin pits (HP:0100277)4.04420573
22Mesangial abnormality (HP:0001966)4.03246127
23Facial diplegia (HP:0001349)4.02061395
24Cholecystitis (HP:0001082)3.86650729
25Abnormal gallbladder physiology (HP:0012438)3.86650729
26Retinal dysplasia (HP:0007973)3.73555363
27Abnormality of the vocal cords (HP:0008777)3.70818924
28Anomalous pulmonary venous return (HP:0010772)3.69784976
29Bifid tongue (HP:0010297)3.67327950
30Testicular atrophy (HP:0000029)3.63359582
31Abnormality of the pulmonary veins (HP:0011718)3.55204609
32Adrenal hypoplasia (HP:0000835)3.48556456
33Gait imbalance (HP:0002141)3.45241492
34Myokymia (HP:0002411)3.42070099
35Limb dystonia (HP:0002451)3.38268915
36Dry hair (HP:0011359)3.31554074
37Congenital primary aphakia (HP:0007707)3.25007872
38Underdeveloped supraorbital ridges (HP:0009891)3.21946392
39Abnormal ciliary motility (HP:0012262)3.19759541
40Clumsiness (HP:0002312)3.17720781
41Pancreatic cysts (HP:0001737)3.10484339
42Hand muscle atrophy (HP:0009130)3.09274653
43Atonic seizures (HP:0010819)3.07024014
44Tongue fasciculations (HP:0001308)3.03443241
45Facial hemangioma (HP:0000329)3.02541453
46True hermaphroditism (HP:0010459)3.00867033
47Myopathic facies (HP:0002058)2.90047097
48Gout (HP:0001997)2.86435591
49Pancreatic fibrosis (HP:0100732)2.85579652
50Germ cell neoplasia (HP:0100728)2.85302267
51Focal motor seizures (HP:0011153)2.85269662
52Nephrogenic diabetes insipidus (HP:0009806)2.82732707
53Hyperventilation (HP:0002883)2.77177739
54Degeneration of anterior horn cells (HP:0002398)2.76461883
55Abnormality of the anterior horn cell (HP:0006802)2.76461883
56Torticollis (HP:0000473)2.74029243
57Occipital encephalocele (HP:0002085)2.71391626
58Muscle fibrillation (HP:0010546)2.70364436
59Resting tremor (HP:0002322)2.69989528
60Neonatal short-limb short stature (HP:0008921)2.69411680
61Female pseudohermaphroditism (HP:0010458)2.68732833
62Skin pits (HP:0100276)2.68670235
63Insidious onset (HP:0003587)2.67259757
64Termporal pattern (HP:0011008)2.67259757
65Biconcave vertebral bodies (HP:0004586)2.66618078
66Medial flaring of the eyebrow (HP:0010747)2.64740158
67Renal salt wasting (HP:0000127)2.63850084
68Sensory axonal neuropathy (HP:0003390)2.63809406
69Vaginal atresia (HP:0000148)2.61432381
70Bulbar palsy (HP:0001283)2.59786654
71Poor coordination (HP:0002370)2.56575312
72Primary adrenal insufficiency (HP:0008207)2.55635494
73Ankle clonus (HP:0011448)2.53718164
74Genital tract atresia (HP:0001827)2.51592072
75Capillary hemangiomas (HP:0005306)2.51109313
76Abnormal respiratory motile cilium morphology (HP:0005938)2.49863221
77Abnormal respiratory epithelium morphology (HP:0012253)2.49863221
78Widely spaced teeth (HP:0000687)2.49030793
79Distal upper limb amyotrophy (HP:0007149)2.48989403
80Upper limb amyotrophy (HP:0009129)2.48989403
81Urinary urgency (HP:0000012)2.48567641
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.47749498
83Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.47749498
84Papilledema (HP:0001085)2.45157250
85Bronchiectasis (HP:0002110)2.44575490
86J-shaped sella turcica (HP:0002680)2.43986826
87Akinesia (HP:0002304)2.42846475
88Enlarged kidneys (HP:0000105)2.41023971
89Woolly hair (HP:0002224)2.39741163
90Protrusio acetabuli (HP:0003179)2.39713555
91Febrile seizures (HP:0002373)2.37503412
92Deep venous thrombosis (HP:0002625)2.36188330
93Progressive inability to walk (HP:0002505)2.35259987
94Nephronophthisis (HP:0000090)2.34760538
95Heterotopia (HP:0002282)2.32835085
96Left ventricular hypertrophy (HP:0001712)2.31229590
97Myotonia (HP:0002486)2.31130031
98Neuroendocrine neoplasm (HP:0100634)2.30262108
99Craniofacial dystonia (HP:0012179)2.29594084
100Lip pit (HP:0100267)2.27915856
101Abnormal tarsal ossification (HP:0008369)2.20013118
102Ovarian neoplasm (HP:0100615)2.18940749
103Focal dystonia (HP:0004373)2.17573461
104Neoplasm of the peripheral nervous system (HP:0100007)2.14254503
105Spontaneous abortion (HP:0005268)2.14078661
106Abnormality of the labia minora (HP:0012880)2.14064875
107Papillary thyroid carcinoma (HP:0002895)2.13528833
108Abnormal delayed hypersensitivity skin test (HP:0002963)2.10590285
109Disproportionate short-trunk short stature (HP:0003521)2.09144358
110Genetic anticipation (HP:0003743)2.07946396
111Hypoplastic pelvis (HP:0008839)2.06554880
112Postaxial hand polydactyly (HP:0001162)2.05416911
113Cavernous hemangioma (HP:0001048)2.02887875
114Abnormality of the lumbar spine (HP:0100712)2.02872367
115Aplasia/Hypoplasia of the lens (HP:0008063)2.02194310
116Infertility (HP:0000789)2.01564432
117Respiratory insufficiency due to defective ciliary clearance (HP:0200073)10.3167080
118Abnormality of the corticospinal tract (HP:0002492)1.99556788
119Tetralogy of Fallot (HP:0001636)1.99184713
120Myelomeningocele (HP:0002475)1.98707370
121Bronchitis (HP:0012387)1.98632651
122Protruding tongue (HP:0010808)1.97502767
123Abolished electroretinogram (ERG) (HP:0000550)1.97087193
124Drooling (HP:0002307)1.96015275
125Excessive salivation (HP:0003781)1.96015275
126Hemiplegia (HP:0002301)1.95768698
127Hyperglycinemia (HP:0002154)1.95450777
128Opisthotonus (HP:0002179)1.94694876
129Dysphonia (HP:0001618)1.91506458
130Specific learning disability (HP:0001328)1.89733718
131Cortical dysplasia (HP:0002539)1.89733221
132Menstrual irregularities (HP:0000858)1.88935535
133Thoracic kyphosis (HP:0002942)1.88773178
134Male pseudohermaphroditism (HP:0000037)1.85484340
135Cystic liver disease (HP:0006706)1.85404694
136Spinal muscular atrophy (HP:0007269)1.85303210
137Vitreoretinal degeneration (HP:0000655)1.85155709
138Inappropriate behavior (HP:0000719)1.84736033
139Abnormal sex determination (HP:0012244)1.84704250
140Sex reversal (HP:0012245)1.84704250
141Tinnitus (HP:0000360)1.84346156
142Porencephaly (HP:0002132)1.83940348
143Aplasia involving bones of the upper limbs (HP:0009823)1.83166963
144Aplasia of the phalanges of the hand (HP:0009802)1.83166963
145Aplasia involving bones of the extremities (HP:0009825)1.83166963
146Agitation (HP:0000713)1.80086874
147Atrophy/Degeneration involving motor neurons (HP:0007373)1.79812447
148Birth length less than 3rd percentile (HP:0003561)1.79633375
149Tachypnea (HP:0002789)1.79142242
150Hypoplasia of the uterus (HP:0000013)1.78546857
151Abnormality of dentin (HP:0010299)1.77261183
152Impaired vibration sensation in the lower limbs (HP:0002166)1.76789318
153Severe visual impairment (HP:0001141)1.76788413
154Gynecomastia (HP:0000771)1.75895047
155Abnormality of the renal medulla (HP:0100957)1.75129885
156Hypoventilation (HP:0002791)1.74822930
157Broad-based gait (HP:0002136)1.74643969
158Short tibia (HP:0005736)1.73054354
159Vertebral compression fractures (HP:0002953)1.73004374
160Posterior subcapsular cataract (HP:0007787)1.72497439
161Fibular hypoplasia (HP:0003038)1.71123092
162Broad forehead (HP:0000337)1.70219014
163Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69766349
164Abnormality of alanine metabolism (HP:0010916)1.69766349
165Hyperalaninemia (HP:0003348)1.69766349
166Abnormal hemoglobin (HP:0011902)1.69576743
167Fibular aplasia (HP:0002990)1.69515906
168Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.68364248
169Vertebral hypoplasia (HP:0008417)1.68364248
170Absent speech (HP:0001344)1.68338982
171Renal agenesis (HP:0000104)1.68198084
172Aplasia/hypoplasia of the uterus (HP:0008684)1.67437528
173Complete atrioventricular canal defect (HP:0001674)1.66190597
174Abnormality of the lower motor neuron (HP:0002366)1.65487975
175Renal cortical cysts (HP:0000803)1.62004753
176Postural instability (HP:0002172)1.61436798
177Urinary bladder sphincter dysfunction (HP:0002839)1.60212563
178Bronchomalacia (HP:0002780)1.57783561
179Hyperuricemia (HP:0002149)1.53373125
180Increased purine levels (HP:0004368)1.53373125
181Osteomalacia (HP:0002749)1.53010959
182Atrioventricular canal defect (HP:0006695)1.52408374
183Shoulder girdle muscle weakness (HP:0003547)1.51923704
184Preaxial foot polydactyly (HP:0001841)1.49409703
185Deformed sella turcica (HP:0002681)1.49271341
186Hypoplastic iliac wings (HP:0002866)1.48859087
187Abnormality of the acetabulum (HP:0003170)1.48764763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR25.30321355
2MOS4.66642965
3BRD44.31014506
4MYLK3.70744080
5TAOK33.60518811
6PRPF4B3.36312498
7ARAF3.27527846
8ACVR1B2.92971884
9ERBB42.90858298
10MUSK2.76840285
11MAP3K62.74770304
12STK38L2.70181997
13LATS22.53851530
14TAOK22.44153013
15LATS12.41592880
16MAP3K92.15614399
17CAMK1D2.12788556
18PHKG22.11819563
19PHKG12.11819563
20RPS6KL12.06753383
21RPS6KC12.06753383
22TTK2.01077162
23AKT31.97504474
24CSNK1G11.96737194
25KSR21.95796019
26RPS6KA61.93236657
27STK41.87032736
28BRAF1.82131264
29RPS6KA51.79696571
30CSNK1G31.79587995
31RPS6KA21.72870343
32PAK61.72386152
33CSNK1A1L1.72108563
34NLK1.67840156
35PASK1.67575909
36CSNK1G21.66335601
37CASK1.63146130
38NTRK31.62604504
39MAP3K131.61564992
40RPS6KA41.58363061
41PKN21.56127677
42DYRK31.55861894
43RAF11.52898730
44TNK21.48825231
45BCR1.43482936
46MAP2K71.41386189
47CDK71.39342765
48INSRR1.37895671
49DYRK21.32870685
50CAMK2B1.32457760
51PINK11.31531038
52CAMK2D1.27016043
53PDK21.26873033
54NME11.22898588
55TNIK1.19954124
56STK161.18675846
57YES11.17450652
58DAPK31.17270917
59CAMK2G1.14271772
60CDK81.12717210
61DYRK1B1.12683531
62STK101.12590174
63MAPK71.12294099
64PRKD31.08117322
65CDK91.05184056
66BCKDK1.04375847
67PLK41.03717282
68EPHA41.02059414
69CDC71.01837986
70PKN11.01084514
71VRK21.00611384
72MAP3K40.98930848
73MAP2K60.98719149
74ABL20.97519480
75CAMK1G0.90098475
76PAK10.89084264
77CAMK2A0.88194487
78RPS6KA10.87670811
79PLK20.87230067
80MAPKAPK50.87061881
81MELK0.86428936
82PRKCE0.86160646
83MKNK10.85982273
84SGK2230.84285800
85SGK4940.84285800
86CHEK20.84029351
87STK380.82626118
88PAK30.81933780
89MAPK40.80091337
90ADRBK10.79617415
91MARK30.75620263
92PRKD20.75616489
93CAMK40.75277215
94STK30.75125462
95PRKACG0.74569742
96ATM0.73611651
97PRKACA0.70712079
98KSR10.70264096
99EIF2AK10.69405211
100SGK20.68096214
101STK110.67327186
102MAPK130.66669006
103TAOK10.66041586
104PIM10.64967486
105RIPK10.64273004
106MARK20.63251447
107PRKCZ0.59536273
108PDPK10.58235940
109MKNK20.58097738
110RPS6KB10.58094755
111ICK0.57663006
112PLK10.57354065
113EPHB10.57236700
114ERBB30.57030328
115CHUK0.56632389
116PRKD10.56506324
117HIPK20.56183763
118PRKCD0.55881525
119IKBKB0.54875177
120DYRK1A0.53552039
121PRKAA10.51341951
122STK390.50335131
123PRKAA20.49521186
124NUAK10.49007077
125PAK20.48885928
126CDK120.48689481
127NTRK20.48608342
128SGK30.45530632
129WNK30.44966584
130MAP2K40.44484361
131ADRBK20.44244470
132OBSCN0.43333740
133PRKG10.41485134
134MARK10.40204357
135GRK50.40154394
136MAPK10.39141502
137CDK190.37697626
138PRKDC0.37691635
139VRK10.37155267
140CDK40.35008711
141DMPK0.34732176
142NEK20.34251984
143ABL10.33387013
144TRIB30.33379499
145MAP3K70.33055960
146CDC42BPA0.32459519
147CDK50.32429113
148RET0.31055874
149CSNK1D0.28544579
150SGK10.28279877
151ROCK20.27641553
152MAP3K120.26728097
153AURKA0.26472388
154TYRO30.26385018
155LRRK20.26138070
156OXSR10.22048943
157CSNK1A10.21924403
158DAPK20.20792469
159ILK0.20166388
160RPS6KA30.19913125
161CSNK1E0.19766038

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047408.88905738
2Fatty acid elongation_Homo sapiens_hsa000624.73607659
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.54472949
4Vitamin digestion and absorption_Homo sapiens_hsa049773.30837072
5Ovarian steroidogenesis_Homo sapiens_hsa049133.28859143
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.25386983
7Glutathione metabolism_Homo sapiens_hsa004803.15227270
8Hedgehog signaling pathway_Homo sapiens_hsa043402.45356873
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.22068875
10Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.20167096
11Arginine and proline metabolism_Homo sapiens_hsa003302.18432390
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.13994395
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.06144666
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01047412
15Chemical carcinogenesis_Homo sapiens_hsa052041.96371701
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.91266503
17Oocyte meiosis_Homo sapiens_hsa041141.88965189
18Glutamatergic synapse_Homo sapiens_hsa047241.86673098
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78152407
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76521922
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.74426830
22Protein export_Homo sapiens_hsa030601.72837470
23RNA degradation_Homo sapiens_hsa030181.69380182
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.67127341
25Basal cell carcinoma_Homo sapiens_hsa052171.64747980
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61011445
27Dorso-ventral axis formation_Homo sapiens_hsa043201.60885336
28Morphine addiction_Homo sapiens_hsa050321.55991933
29Ether lipid metabolism_Homo sapiens_hsa005651.55369516
30Pyruvate metabolism_Homo sapiens_hsa006201.55060472
31GABAergic synapse_Homo sapiens_hsa047271.53072039
32cAMP signaling pathway_Homo sapiens_hsa040241.50821588
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50467854
34Circadian entrainment_Homo sapiens_hsa047131.46438039
35Insulin secretion_Homo sapiens_hsa049111.41816716
36Folate biosynthesis_Homo sapiens_hsa007901.39527047
37GnRH signaling pathway_Homo sapiens_hsa049121.34125155
38Nicotine addiction_Homo sapiens_hsa050331.32955510
39Oxidative phosphorylation_Homo sapiens_hsa001901.32342373
40Cholinergic synapse_Homo sapiens_hsa047251.25803407
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.24417846
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24217935
43Salivary secretion_Homo sapiens_hsa049701.22088031
44Parkinsons disease_Homo sapiens_hsa050121.18971706
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18463889
46Selenocompound metabolism_Homo sapiens_hsa004501.17515447
47Synaptic vesicle cycle_Homo sapiens_hsa047211.17017600
48cGMP-PKG signaling pathway_Homo sapiens_hsa040221.16406758
49Huntingtons disease_Homo sapiens_hsa050161.12941155
50Vibrio cholerae infection_Homo sapiens_hsa051101.09619825
51Gastric acid secretion_Homo sapiens_hsa049711.07200606
52Cell cycle_Homo sapiens_hsa041101.07110824
53Long-term potentiation_Homo sapiens_hsa047201.07012923
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06838454
55Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04193246
56Sulfur relay system_Homo sapiens_hsa041221.03790335
57Long-term depression_Homo sapiens_hsa047301.02751172
58Nucleotide excision repair_Homo sapiens_hsa034201.01511411
59Serotonergic synapse_Homo sapiens_hsa047261.01314378
60Dopaminergic synapse_Homo sapiens_hsa047281.01019335
61Fatty acid metabolism_Homo sapiens_hsa012121.00730635
62Vascular smooth muscle contraction_Homo sapiens_hsa042701.00336483
63Ribosome_Homo sapiens_hsa030100.97513574
64Estrogen signaling pathway_Homo sapiens_hsa049150.97244993
65Base excision repair_Homo sapiens_hsa034100.95506538
66Histidine metabolism_Homo sapiens_hsa003400.94142190
67Linoleic acid metabolism_Homo sapiens_hsa005910.90750040
68Complement and coagulation cascades_Homo sapiens_hsa046100.89979280
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.89542406
70Circadian rhythm_Homo sapiens_hsa047100.89509202
71Vitamin B6 metabolism_Homo sapiens_hsa007500.89123984
72Carbon metabolism_Homo sapiens_hsa012000.84881338
73Basal transcription factors_Homo sapiens_hsa030220.82400192
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81998438
75Pancreatic cancer_Homo sapiens_hsa052120.81063742
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80161879
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80152887
78Fatty acid biosynthesis_Homo sapiens_hsa000610.79734907
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.79486520
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.79202549
81Choline metabolism in cancer_Homo sapiens_hsa052310.78710214
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78383475
83Melanogenesis_Homo sapiens_hsa049160.77467788
84beta-Alanine metabolism_Homo sapiens_hsa004100.76665557
85Oxytocin signaling pathway_Homo sapiens_hsa049210.75136499
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74544500
87Bile secretion_Homo sapiens_hsa049760.74371999
88Metabolic pathways_Homo sapiens_hsa011000.74317795
89Gap junction_Homo sapiens_hsa045400.73511002
90Taste transduction_Homo sapiens_hsa047420.71780393
91Wnt signaling pathway_Homo sapiens_hsa043100.71165762
92Calcium signaling pathway_Homo sapiens_hsa040200.69666951
93Cardiac muscle contraction_Homo sapiens_hsa042600.69415341
94Alzheimers disease_Homo sapiens_hsa050100.67133148
95Dilated cardiomyopathy_Homo sapiens_hsa054140.67074032
96Spliceosome_Homo sapiens_hsa030400.65870691
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65584035
98Renal cell carcinoma_Homo sapiens_hsa052110.65159608
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64868941
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64812315
101Collecting duct acid secretion_Homo sapiens_hsa049660.64524278
102Phototransduction_Homo sapiens_hsa047440.62759683
103Ras signaling pathway_Homo sapiens_hsa040140.61931717
104Pancreatic secretion_Homo sapiens_hsa049720.60835208
105Cocaine addiction_Homo sapiens_hsa050300.59219349
106Axon guidance_Homo sapiens_hsa043600.58781575
107TGF-beta signaling pathway_Homo sapiens_hsa043500.58709675
108Renin secretion_Homo sapiens_hsa049240.58287124
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57408966
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.57309986
111PPAR signaling pathway_Homo sapiens_hsa033200.56066940
112Propanoate metabolism_Homo sapiens_hsa006400.55086752
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54175824
114Prolactin signaling pathway_Homo sapiens_hsa049170.53259254
115Thyroid hormone synthesis_Homo sapiens_hsa049180.51579167
116Sphingolipid metabolism_Homo sapiens_hsa006000.51562962
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49060156
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47497316
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46650312
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46620681
121MAPK signaling pathway_Homo sapiens_hsa040100.45980361
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.45650716
123Phenylalanine metabolism_Homo sapiens_hsa003600.45502871
124Amphetamine addiction_Homo sapiens_hsa050310.44924666
125ECM-receptor interaction_Homo sapiens_hsa045120.42580605
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42418271
127RNA polymerase_Homo sapiens_hsa030200.42111277
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41478450
129Cyanoamino acid metabolism_Homo sapiens_hsa004600.41052984
130Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.40669856
131Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.40457031
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.40373430
133Chemokine signaling pathway_Homo sapiens_hsa040620.40265822
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40090481
135Protein digestion and absorption_Homo sapiens_hsa049740.39642008
136Alcoholism_Homo sapiens_hsa050340.39117279
137Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38850715
138Primary bile acid biosynthesis_Homo sapiens_hsa001200.38137600
139Phosphatidylinositol signaling system_Homo sapiens_hsa040700.37408510
140Lysosome_Homo sapiens_hsa041420.37335878
141Sulfur metabolism_Homo sapiens_hsa009200.35385019
142Butanoate metabolism_Homo sapiens_hsa006500.35084635
143Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.34816545
144Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34571134
145MicroRNAs in cancer_Homo sapiens_hsa052060.34125715
146ErbB signaling pathway_Homo sapiens_hsa040120.33212110
147NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32961385
148Tyrosine metabolism_Homo sapiens_hsa003500.32553937
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.32500498
150Galactose metabolism_Homo sapiens_hsa000520.32078471
151Biosynthesis of amino acids_Homo sapiens_hsa012300.31227220
152Peroxisome_Homo sapiens_hsa041460.30987120
153RNA transport_Homo sapiens_hsa030130.30544816
154Colorectal cancer_Homo sapiens_hsa052100.29996415
155Platelet activation_Homo sapiens_hsa046110.29358289
156Steroid biosynthesis_Homo sapiens_hsa001000.28917874
157Arginine biosynthesis_Homo sapiens_hsa002200.28250101
158Starch and sucrose metabolism_Homo sapiens_hsa005000.28012816
159Purine metabolism_Homo sapiens_hsa002300.27549951
160Endometrial cancer_Homo sapiens_hsa052130.27465423
161Tryptophan metabolism_Homo sapiens_hsa003800.27023376
162Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25508509
163Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25305772
164Nitrogen metabolism_Homo sapiens_hsa009100.25056940
165Glucagon signaling pathway_Homo sapiens_hsa049220.24586600
166Hippo signaling pathway_Homo sapiens_hsa043900.24446925
167Retinol metabolism_Homo sapiens_hsa008300.24035903
168Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23946256
169Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22801273
170Arachidonic acid metabolism_Homo sapiens_hsa005900.21101418
171N-Glycan biosynthesis_Homo sapiens_hsa005100.19333570
172Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18314645

Most similar genes based on co-expression Upload to Enrichr

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