FAU

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N terminus and ribosomal protein S30 at the C terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome and displays antimicrobial activity. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* viral transcription (GO:0019083)8.30025444
2* translational termination (GO:0006415)7.96864295
3ribosomal small subunit assembly (GO:0000028)7.73470276
4ribosomal small subunit biogenesis (GO:0042274)7.62695449
5* translational elongation (GO:0006414)6.93277015
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.76800337
7* cotranslational protein targeting to membrane (GO:0006613)6.63525049
8* protein targeting to ER (GO:0045047)6.63012285
9maturation of SSU-rRNA (GO:0030490)6.60148557
10* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.30510945
11* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.22462769
12* cellular protein complex disassembly (GO:0043624)6.22286057
13* viral life cycle (GO:0019058)6.22034303
14* protein localization to endoplasmic reticulum (GO:0070972)6.22005598
15* translational initiation (GO:0006413)6.18300101
16ribosomal large subunit biogenesis (GO:0042273)6.16462245
17chaperone-mediated protein transport (GO:0072321)5.65034411
18* protein complex disassembly (GO:0043241)5.47016231
19respiratory electron transport chain (GO:0022904)5.20194774
20* macromolecular complex disassembly (GO:0032984)5.12571228
21electron transport chain (GO:0022900)5.08140448
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.99047637
23DNA deamination (GO:0045006)4.98700482
24ribonucleoprotein complex biogenesis (GO:0022613)4.91450843
25* translation (GO:0006412)4.72839836
26* nuclear-transcribed mRNA catabolic process (GO:0000956)4.52214331
27formation of translation preinitiation complex (GO:0001731)4.48129408
28* protein targeting to membrane (GO:0006612)4.36260897
29* mRNA catabolic process (GO:0006402)4.28718530
30* RNA catabolic process (GO:0006401)4.03559248
31rRNA processing (GO:0006364)4.00247099
32ATP biosynthetic process (GO:0006754)3.96263911
33protein complex biogenesis (GO:0070271)3.95971636
34rRNA metabolic process (GO:0016072)3.85663865
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.81306109
36DNA strand elongation involved in DNA replication (GO:0006271)3.77044421
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.75900164
38telomere maintenance via semi-conservative replication (GO:0032201)3.75700522
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.74069154
40NADH dehydrogenase complex assembly (GO:0010257)3.74069154
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.74069154
42cellular component biogenesis (GO:0044085)3.74012752
43mitochondrial respiratory chain complex assembly (GO:0033108)3.72027339
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.62158026
45ribonucleoside triphosphate biosynthetic process (GO:0009201)3.57160234
46DNA strand elongation (GO:0022616)3.56062052
47proteasome assembly (GO:0043248)3.55244489
48ribosome biogenesis (GO:0042254)3.48859008
49spliceosomal snRNP assembly (GO:0000387)3.46770266
50* protein localization to membrane (GO:0072657)3.45527066
51oxidative phosphorylation (GO:0006119)3.44964808
52protein targeting to mitochondrion (GO:0006626)3.44756636
53regulation of mitochondrial translation (GO:0070129)3.44669206
54ribosome assembly (GO:0042255)3.40566477
55establishment of protein localization to mitochondrion (GO:0072655)3.34670755
56GTP biosynthetic process (GO:0006183)3.33939737
57inner mitochondrial membrane organization (GO:0007007)3.33655563
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.32177357
59hydrogen ion transmembrane transport (GO:1902600)3.31432875
60termination of RNA polymerase III transcription (GO:0006386)3.28026266
61transcription elongation from RNA polymerase III promoter (GO:0006385)3.28026266
62telomere maintenance via recombination (GO:0000722)3.26393128
63pseudouridine synthesis (GO:0001522)3.22233815
64spliceosomal complex assembly (GO:0000245)3.20304023
65DNA replication initiation (GO:0006270)3.16408330
66mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.15510337
67protein neddylation (GO:0045116)3.15464521
68sequestering of actin monomers (GO:0042989)3.14908798
69guanosine-containing compound biosynthetic process (GO:1901070)3.14701441
70nucleobase biosynthetic process (GO:0046112)3.13872880
71energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12016359
72ATP synthesis coupled proton transport (GO:0015986)3.12016359
73protein localization to mitochondrion (GO:0070585)3.11077609
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09441848
75negative regulation of ligase activity (GO:0051352)3.09441848
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.09416944
77ncRNA 3-end processing (GO:0043628)3.09228124
78nucleoside triphosphate biosynthetic process (GO:0009142)3.08594875
79DNA unwinding involved in DNA replication (GO:0006268)3.06637213
80anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05689900
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04701786
82DNA replication checkpoint (GO:0000076)3.02006050
83pyrimidine nucleotide catabolic process (GO:0006244)3.00828549
84purine nucleobase biosynthetic process (GO:0009113)2.99485571
85mitotic recombination (GO:0006312)2.98726261
86* establishment of protein localization to membrane (GO:0090150)2.97961282
87DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97956351
88rRNA modification (GO:0000154)2.97221487
89establishment of integrated proviral latency (GO:0075713)2.96733277
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.95667163
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.95667163
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.93102034
93signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.93102034
94folic acid-containing compound biosynthetic process (GO:0009396)2.92229040
95telomere maintenance via telomere lengthening (GO:0010833)2.91979276
96signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91773031
97signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91773031
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91773031
99signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91701017
100signal transduction involved in DNA damage checkpoint (GO:0072422)2.91701017
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.90179604
102pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.89674626
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.87937366
104protein localization to kinetochore (GO:0034501)2.87124289
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.86587789
106signal transduction involved in cell cycle checkpoint (GO:0072395)2.86499505
107pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.85991911
108* establishment of protein localization to organelle (GO:0072594)2.85135283
109base-excision repair, AP site formation (GO:0006285)2.85114960
110purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.85043217
111purine nucleoside monophosphate biosynthetic process (GO:0009127)2.85043217
112mitochondrial transport (GO:0006839)2.84380044
113* protein targeting (GO:0006605)2.83898614
114pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83262424
115CTP biosynthetic process (GO:0006241)2.81908731
116CTP metabolic process (GO:0046036)2.81908731
117transcription-coupled nucleotide-excision repair (GO:0006283)2.81654068
118UTP metabolic process (GO:0046051)2.81057205
119proton transport (GO:0015992)2.80238524
120deoxyribonucleotide catabolic process (GO:0009264)2.80229558
121antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.79165619
122GDP-mannose metabolic process (GO:0019673)2.77700886
123aerobic respiration (GO:0009060)2.77075409
124ncRNA processing (GO:0034470)2.76591391
125nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76147888
126pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.74608028
127hydrogen transport (GO:0006818)2.73806567
128deoxyribose phosphate catabolic process (GO:0046386)2.70876736
129positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70304781
130regulation of cellular amino acid metabolic process (GO:0006521)2.70196416
131establishment of protein localization to mitochondrial membrane (GO:0090151)2.69234876
132* protein localization to organelle (GO:0033365)2.68869171
133regulation of protein heterodimerization activity (GO:0043497)2.62851497
134transcription from RNA polymerase I promoter (GO:0006360)2.62625791
135termination of RNA polymerase I transcription (GO:0006363)2.62622012
136cytochrome complex assembly (GO:0017004)2.62146098
137viral protein processing (GO:0019082)2.61700889
138mitotic metaphase plate congression (GO:0007080)2.60469215
139ncRNA metabolic process (GO:0034660)2.59530167
140positive regulation of ligase activity (GO:0051351)2.58330043
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.58252230
142chromatin remodeling at centromere (GO:0031055)2.56784795
143* gene expression (GO:0010467)2.55369960
144transcription elongation from RNA polymerase I promoter (GO:0006362)2.54161128
145UTP biosynthetic process (GO:0006228)2.53767107
146protein localization to chromosome, centromeric region (GO:0071459)2.53574454
147CENP-A containing nucleosome assembly (GO:0034080)2.53074781
148regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.52926361
1497-methylguanosine mRNA capping (GO:0006370)2.51837474
150G1/S transition of mitotic cell cycle (GO:0000082)2.49984870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.25787974
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.29559049
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01869321
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.31543874
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17793734
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.15608499
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.11804773
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.05930232
9* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90639186
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86399143
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85783214
12* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73758660
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67118094
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.66615417
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56718232
16* XRN2_22483619_ChIP-Seq_HELA_Human2.55448333
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48074667
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44892192
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36437248
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31892284
21VDR_23849224_ChIP-Seq_CD4+_Human2.27654519
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19359518
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08510343
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.00151834
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99755490
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95962939
27TTF2_22483619_ChIP-Seq_HELA_Human1.93071094
28FOXP3_21729870_ChIP-Seq_TREG_Human1.92203293
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90678416
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84279991
31GABP_19822575_ChIP-Seq_HepG2_Human1.75165709
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71118990
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64998338
34MYC_22102868_ChIP-Seq_BL_Human1.63841321
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.63792295
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.63690893
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63199270
38ELK1_19687146_ChIP-ChIP_HELA_Human1.61349414
39* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58652860
40FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56268036
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51576205
42VDR_21846776_ChIP-Seq_THP-1_Human1.50395417
43CTCF_18555785_ChIP-Seq_MESCs_Mouse1.48022474
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.47947883
45CIITA_25753668_ChIP-Seq_RAJI_Human1.47136342
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.46876659
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.46739904
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44425505
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.39759612
50STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39732605
51TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39144885
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38136513
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.37785505
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37757274
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.34807723
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34502471
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33675697
58* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33352350
59ELK1_22589737_ChIP-Seq_MCF10A_Human1.31658184
60* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.30254261
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30087559
62* KDM5A_27292631_Chip-Seq_BREAST_Human1.29947549
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29544884
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28892425
65AR_21909140_ChIP-Seq_LNCAP_Human1.28630819
66CTCF_26484167_Chip-Seq_Bcells_Mouse1.26920654
67CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26663190
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.26247812
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24797421
70CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24390624
71E2F1_21310950_ChIP-Seq_MCF-7_Human1.24022726
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21878436
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19894091
74LXR_22292898_ChIP-Seq_THP-1_Human1.19098651
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17114997
76SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16378071
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.16186887
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16033211
79SPI1_23547873_ChIP-Seq_NB4_Human1.15509769
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.15087329
81ELF1_20517297_ChIP-Seq_JURKAT_Human1.13586334
82BCL6_27268052_Chip-Seq_Bcells_Human1.12603481
83IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12055869
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11768541
85P68_20966046_ChIP-Seq_HELA_Human1.11494888
86MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11447554
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09824405
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09461321
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09401135
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09274104
91* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09159050
92SA1_27219007_Chip-Seq_ERYTHROID_Human1.07574101
93* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07220998
94* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06768794
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04431650
96* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04382197
97YY1_22570637_ChIP-Seq_MALME-3M_Human1.03259798
98TFEB_21752829_ChIP-Seq_HELA_Human1.03037257
99BP1_19119308_ChIP-ChIP_Hs578T_Human1.01336220
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00153313
101SA1_27219007_Chip-Seq_Bcells_Human0.99886055
102MAF_26560356_Chip-Seq_TH2_Human0.99215837
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.98696166
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97781859
105SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96327036
106MYC_18940864_ChIP-ChIP_HL60_Human0.95648740
107ZNF263_19887448_ChIP-Seq_K562_Human0.95462011
108BCOR_27268052_Chip-Seq_Bcells_Human0.95396024
109CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94217826
110E2F1_20622854_ChIP-Seq_HELA_Human0.93523364
111SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93489193
112RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.92645290
113TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92157578
114CTCF_20526341_ChIP-Seq_ESCs_Human0.91744753
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90962531
116MAF_26560356_Chip-Seq_TH1_Human0.89386676
117* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89246282
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89229666
119* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88297824
120UTX_26944678_Chip-Seq_JUKART_Human0.88292281
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88054804
122CTCF_21964334_Chip-Seq_Bcells_Human0.87687156
123TP63_19390658_ChIP-ChIP_HaCaT_Human0.87624617
124PHF8_20622854_ChIP-Seq_HELA_Human0.86534269
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.84888955
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.84888955
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.84888955
128VDR_24763502_ChIP-Seq_THP-1_Human0.84497519
129* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83820948

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.76005409
2MP0004957_abnormal_blastocyst_morpholog3.86255553
3MP0009379_abnormal_foot_pigmentation3.17997487
4MP0003077_abnormal_cell_cycle3.14987654
5MP0003111_abnormal_nucleus_morphology3.12153332
6MP0010094_abnormal_chromosome_stability2.84637589
7MP0006292_abnormal_olfactory_placode2.82993104
8MP0002163_abnormal_gland_morphology2.47143371
9MP0009333_abnormal_splenocyte_physiolog2.41732852
10MP0003136_yellow_coat_color2.27513709
11MP0008057_abnormal_DNA_replication2.22064229
12MP0008932_abnormal_embryonic_tissue2.20674170
13MP0008995_early_reproductive_senescence2.15557395
14MP0008058_abnormal_DNA_repair2.09726153
15MP0000490_abnormal_crypts_of2.08608213
16MP0008007_abnormal_cellular_replicative2.07790237
17MP0010352_gastrointestinal_tract_polyps2.04484024
18MP0002653_abnormal_ependyma_morphology1.93592374
19MP0002396_abnormal_hematopoietic_system1.92130227
20MP0003763_abnormal_thymus_physiology1.86551276
21MP0003011_delayed_dark_adaptation1.85132514
22MP0001730_embryonic_growth_arrest1.83758932
23MP0003786_premature_aging1.74174031
24MP0000350_abnormal_cell_proliferation1.74167446
25MP0000372_irregular_coat_pigmentation1.73241993
26MP0000685_abnormal_immune_system1.68715953
27MP0001835_abnormal_antigen_presentation1.65620592
28MP0001800_abnormal_humoral_immune1.61184486
29MP0003186_abnormal_redox_activity1.59861555
30MP0003718_maternal_effect1.59549412
31MP0002132_abnormal_respiratory_system1.57240842
32MP0000566_synostosis1.55259195
33MP0003806_abnormal_nucleotide_metabolis1.54719636
34MP0002398_abnormal_bone_marrow1.53367699
35MP0002722_abnormal_immune_system1.52319072
36MP0010030_abnormal_orbit_morphology1.46599882
37MP0000689_abnormal_spleen_morphology1.44921833
38MP0003123_paternal_imprinting1.44151861
39MP0001853_heart_inflammation1.43980721
40MP0002019_abnormal_tumor_incidence1.43391162
41MP0000858_altered_metastatic_potential1.43365213
42MP0002452_abnormal_antigen_presenting1.42913311
43MP0000703_abnormal_thymus_morphology1.40524042
44MP0003436_decreased_susceptibility_to1.39807471
45MP0002420_abnormal_adaptive_immunity1.36302633
46MP0000313_abnormal_cell_death1.35982890
47MP0001819_abnormal_immune_cell1.35092235
48MP0002723_abnormal_immune_serum1.32657720
49MP0001905_abnormal_dopamine_level1.31740271
50MP0000716_abnormal_immune_system1.31711332
51MP0001346_abnormal_lacrimal_gland1.30648951
52MP0002429_abnormal_blood_cell1.30641754
53MP0005000_abnormal_immune_tolerance1.29087520
54MP0005671_abnormal_response_to1.29025392
55MP0005025_abnormal_response_to1.26431105
56MP0002405_respiratory_system_inflammati1.26094618
57MP0004808_abnormal_hematopoietic_stem1.25318758
58MP0001697_abnormal_embryo_size1.24485739
59MP0002938_white_spotting1.24347504
60MP0009785_altered_susceptibility_to1.23621974
61MP0002080_prenatal_lethality1.23541159
62MP0010155_abnormal_intestine_physiology1.22329019
63MP0003315_abnormal_perineum_morphology1.21595208
64MP0005023_abnormal_wound_healing1.20036002
65MP0002095_abnormal_skin_pigmentation1.20030297
66MP0000049_abnormal_middle_ear1.19440649
67MP0005387_immune_system_phenotype1.17002295
68MP0001790_abnormal_immune_system1.17002295
69MP0004142_abnormal_muscle_tone1.16483476
70MP0002822_catalepsy1.16153675
71MP0005380_embryogenesis_phenotype1.14547910
72MP0001672_abnormal_embryogenesis/_devel1.14547910
73MP0001873_stomach_inflammation1.12228602
74MP0005379_endocrine/exocrine_gland_phen1.11723163
75MP0003866_abnormal_defecation1.08221551
76MP0002148_abnormal_hypersensitivity_rea1.08208097
77MP0003938_abnormal_ear_development1.07630266
78MP0003984_embryonic_growth_retardation1.04956684
79MP0002088_abnormal_embryonic_growth/wei1.03193096
80MP0005397_hematopoietic_system_phenotyp1.03170725
81MP0001545_abnormal_hematopoietic_system1.03170725
82MP0001529_abnormal_vocalization1.03146194
83MP0002166_altered_tumor_susceptibility1.02572172
84MP0002085_abnormal_embryonic_tissue1.02550048
85MP0002638_abnormal_pupillary_reflex1.01688062
86MP0010307_abnormal_tumor_latency1.01275907
87MP0001986_abnormal_taste_sensitivity0.99133671
88MP0009840_abnormal_foam_cell0.98499132
89MP0000678_abnormal_parathyroid_gland0.96052219
90MP0003567_abnormal_fetal_cardiomyocyte0.95965388
91MP0001919_abnormal_reproductive_system0.95161308
92MP0002086_abnormal_extraembryonic_tissu0.93531935
93MP0000358_abnormal_cell_content/0.93339859
94MP0005084_abnormal_gallbladder_morpholo0.92980144
95MP0001881_abnormal_mammary_gland0.90597650
96MP0000477_abnormal_intestine_morphology0.90465692
97MP0006072_abnormal_retinal_apoptosis0.88981238
98MP0002006_tumorigenesis0.88746074
99MP0000750_abnormal_muscle_regeneration0.88544187
100MP0003878_abnormal_ear_physiology0.87009340
101MP0005377_hearing/vestibular/ear_phenot0.87009340
102MP0001845_abnormal_inflammatory_respons0.86703384
103MP0001663_abnormal_digestive_system0.86701721
104MP0001764_abnormal_homeostasis0.86067523
105MP0004947_skin_inflammation0.86041185
106MP0003448_altered_tumor_morphology0.85053467
107MP0002277_abnormal_respiratory_mucosa0.84295394
108MP0002249_abnormal_larynx_morphology0.82532433
109MP0002837_dystrophic_cardiac_calcinosis0.81720078
110MP0002160_abnormal_reproductive_system0.81704185
111MP0000631_abnormal_neuroendocrine_gland0.80638897
112MP0002419_abnormal_innate_immunity0.80571440
113MP0002210_abnormal_sex_determination0.80474736
114MP0004197_abnormal_fetal_growth/weight/0.79788658
115MP0002084_abnormal_developmental_patter0.79275547
116MP0005389_reproductive_system_phenotype0.78829347
117MP0005075_abnormal_melanosome_morpholog0.78805643
118MP0005174_abnormal_tail_pigmentation0.78794591
119MP0004742_abnormal_vestibular_system0.76638902
120MP0008789_abnormal_olfactory_epithelium0.75592051
121MP0009053_abnormal_anal_canal0.75519937
122MP0004381_abnormal_hair_follicle0.73439909
123MP0005381_digestive/alimentary_phenotyp0.72442931
124MP0001727_abnormal_embryo_implantation0.70092925
125MP0005501_abnormal_skin_physiology0.69549954
126MP0004133_heterotaxia0.69358357
127MP0000465_gastrointestinal_hemorrhage0.68932705
128MP0002111_abnormal_tail_morphology0.68558848
129MP0005464_abnormal_platelet_physiology0.68260813
130MP0000026_abnormal_inner_ear0.67479332
131MP0006036_abnormal_mitochondrial_physio0.67126082
132MP0005645_abnormal_hypothalamus_physiol0.67104277
133MP0009278_abnormal_bone_marrow0.66388420
134MP0000343_altered_response_to0.66087389
135MP0002736_abnormal_nociception_after0.65670226
136MP0005408_hypopigmentation0.64697655
137MP0008469_abnormal_protein_level0.64392826
138MP0005076_abnormal_cell_differentiation0.62385338
139MP0003303_peritoneal_inflammation0.61507555
140MP0006035_abnormal_mitochondrial_morpho0.61369762
141MP0006054_spinal_hemorrhage0.60749101
142MP0001293_anophthalmia0.59711097

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.45420151
2Reticulocytopenia (HP:0001896)6.77667625
3Abnormal number of erythroid precursors (HP:0012131)6.55066451
4Macrocytic anemia (HP:0001972)5.44723534
5Pallor (HP:0000980)4.90367814
6Increased muscle lipid content (HP:0009058)3.84077537
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.65027104
8Multiple enchondromatosis (HP:0005701)3.50937426
9Cerebral edema (HP:0002181)3.47299006
10Oral leukoplakia (HP:0002745)3.40293964
11Trismus (HP:0000211)3.28956013
12Breast hypoplasia (HP:0003187)3.18127071
13Rough bone trabeculation (HP:0100670)3.07236364
14Abnormal hemoglobin (HP:0011902)3.06541127
15Lactic acidosis (HP:0003128)3.06394126
16Carpal bone hypoplasia (HP:0001498)3.02023739
17Thrombocytosis (HP:0001894)3.00733172
18Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.94871320
19Aplastic anemia (HP:0001915)2.83915400
20IgM deficiency (HP:0002850)2.77502876
21Absent thumb (HP:0009777)2.75410633
22Birth length less than 3rd percentile (HP:0003561)2.73946003
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.70498222
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.70498222
25Increased hepatocellular lipid droplets (HP:0006565)2.68691736
26Colon cancer (HP:0003003)2.68514734
27Microretrognathia (HP:0000308)2.60985955
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.54468667
29Exertional dyspnea (HP:0002875)2.54399711
30Selective tooth agenesis (HP:0001592)2.53943148
31Optic disc pallor (HP:0000543)2.53922910
32Leukodystrophy (HP:0002415)2.53300331
33Patellar aplasia (HP:0006443)2.50810747
34Partial duplication of the phalanx of hand (HP:0009999)2.49850392
35Mitochondrial inheritance (HP:0001427)2.49576606
3611 pairs of ribs (HP:0000878)2.49088213
37Partial duplication of thumb phalanx (HP:0009944)2.48801698
38Cerebral hypomyelination (HP:0006808)2.47329698
39Aplasia/Hypoplasia of the patella (HP:0006498)2.44313369
40Abnormality of renal resorption (HP:0011038)2.41691675
41Abnormality of reticulocytes (HP:0004312)2.37398384
42Lipid accumulation in hepatocytes (HP:0006561)2.31375501
43Hepatocellular necrosis (HP:0001404)2.31014876
44Testicular atrophy (HP:0000029)2.29365539
45Acute necrotizing encephalopathy (HP:0006965)2.28121694
46Abnormal trabecular bone morphology (HP:0100671)2.26746454
47Stenosis of the external auditory canal (HP:0000402)2.26627767
48Hypoplasia of the radius (HP:0002984)2.22505448
49Increased CSF lactate (HP:0002490)2.20037869
50Depressed nasal ridge (HP:0000457)2.17670412
51Pustule (HP:0200039)2.15971197
52Increased serum lactate (HP:0002151)2.15049805
53Triphalangeal thumb (HP:0001199)2.14299631
54Agammaglobulinemia (HP:0004432)2.11732507
55Cellular immunodeficiency (HP:0005374)2.11619358
56Petechiae (HP:0000967)2.10495724
57Premature graying of hair (HP:0002216)2.10067552
58Neoplasm of the pancreas (HP:0002894)2.08686327
59Degeneration of anterior horn cells (HP:0002398)2.08641717
60Abnormality of the anterior horn cell (HP:0006802)2.08641717
61Horseshoe kidney (HP:0000085)2.07473186
62Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.06654715
63Abnormal mitochondria in muscle tissue (HP:0008316)2.05935987
64Cleft eyelid (HP:0000625)2.04931976
65Hyperphosphaturia (HP:0003109)2.04646056
66Glycosuria (HP:0003076)2.04025012
67Abnormality of urine glucose concentration (HP:0011016)2.04025012
68Emotional lability (HP:0000712)2.03906403
69Progressive muscle weakness (HP:0003323)2.02713335
70Broad distal phalanx of finger (HP:0009836)2.00923110
71Elevated erythrocyte sedimentation rate (HP:0003565)2.00779076
72Hepatic necrosis (HP:0002605)1.99748944
73Concave nail (HP:0001598)1.99748052
74Lethargy (HP:0001254)1.99681605
75Generalized aminoaciduria (HP:0002909)1.98937615
763-Methylglutaconic aciduria (HP:0003535)1.98848302
77Glossoptosis (HP:0000162)1.98225687
78Granulocytopenia (HP:0001913)1.97492036
79Secondary amenorrhea (HP:0000869)1.96651847
80Increased intramyocellular lipid droplets (HP:0012240)1.96431713
81Absent radius (HP:0003974)1.93457559
82Premature ovarian failure (HP:0008209)1.90092555
83Pancytopenia (HP:0001876)1.89729653
84Panhypogammaglobulinemia (HP:0003139)1.89704846
85Lymphoma (HP:0002665)1.89517601
86Renal Fanconi syndrome (HP:0001994)1.87869142
87Abnormality of T cells (HP:0002843)1.82753285
88Microvesicular hepatic steatosis (HP:0001414)1.81126395
89Respiratory difficulties (HP:0002880)1.81016015
90Sparse eyelashes (HP:0000653)1.80649711
91Abnormality of the preputium (HP:0100587)1.80618311
92Poor head control (HP:0002421)1.79646293
93Absent forearm bone (HP:0003953)1.79256582
94Aplasia involving forearm bones (HP:0009822)1.79256582
95Acute encephalopathy (HP:0006846)1.78804902
96Septo-optic dysplasia (HP:0100842)1.77772437
97Congenital, generalized hypertrichosis (HP:0004540)1.77535348
98Combined immunodeficiency (HP:0005387)1.76393639
99Abnormality of the parietal bone (HP:0002696)1.76019979
100Hypoplasia of the pons (HP:0012110)1.75813435
101Meckel diverticulum (HP:0002245)1.75576827
102Bone marrow hypocellularity (HP:0005528)1.75504480
103Aplasia/Hypoplasia of the thymus (HP:0010515)1.75090424
104CNS demyelination (HP:0007305)1.74332647
105Myokymia (HP:0002411)1.73698437
106Respiratory failure (HP:0002878)1.73255512
107Abnormality of T cell physiology (HP:0011840)1.73025582
108Neutropenia (HP:0001875)1.73014060
109Thick lower lip vermilion (HP:0000179)1.72340600
110Recurrent bronchitis (HP:0002837)1.72168085
111Exercise intolerance (HP:0003546)1.71687368
112T lymphocytopenia (HP:0005403)1.71647987
113Muscle fiber atrophy (HP:0100295)1.71605041
114Basal cell carcinoma (HP:0002671)1.71375978
115Type I transferrin isoform profile (HP:0003642)1.70522708
116Tracheoesophageal fistula (HP:0002575)1.70477259
117Abnormal number of incisors (HP:0011064)1.70119368
118Atresia of the external auditory canal (HP:0000413)1.68155680
119Migraine (HP:0002076)1.67946133
120Abnormality of the umbilical cord (HP:0010881)1.67943893
121Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67860553
122Abnormality of the pons (HP:0007361)1.66605093
123Abnormality of the ileum (HP:0001549)1.65485966
124Myelodysplasia (HP:0002863)1.63630951
125Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.63123152
126Progressive macrocephaly (HP:0004481)1.62992110
127Chronic obstructive pulmonary disease (HP:0006510)1.62432921
128Obstructive lung disease (HP:0006536)1.62432921
129IgG deficiency (HP:0004315)1.61734122
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.61366775
131Abnormality of T cell number (HP:0011839)1.61039794
132Abnormal urine phosphate concentration (HP:0012599)1.60489192
133Dicarboxylic aciduria (HP:0003215)1.60354477
134Abnormality of dicarboxylic acid metabolism (HP:0010995)1.60354477
135Dysphonia (HP:0001618)1.56696525
136Ragged-red muscle fibers (HP:0003200)1.56582927
137Nasolacrimal duct obstruction (HP:0000579)1.56449198
138Maternal diabetes (HP:0009800)1.56398390
139Gliosis (HP:0002171)1.53223176
140X-linked dominant inheritance (HP:0001423)1.53045994
141Increased IgM level (HP:0003496)1.52744903
142Renal tubular dysfunction (HP:0000124)1.51343727
143Hypertensive crisis (HP:0100735)1.49780592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.61373510
2NME24.65698569
3BUB14.42019701
4WEE13.09755084
5TLK13.04621394
6EIF2AK12.70105944
7TESK22.59306123
8MAP4K12.58252435
9EIF2AK32.18073665
10RPS6KB22.16683051
11PIM22.14296172
12LRRK21.99028586
13CDK191.96733237
14STK161.87292450
15EEF2K1.86526760
16SRPK11.83614014
17CDC71.78775454
18NEK21.77345391
19VRK11.70463335
20EPHA21.68334635
21STK101.56395381
22PLK41.55521022
23RPS6KA41.52437865
24MAP3K101.41328176
25IRAK31.39546334
26BLK1.37952093
27AURKB1.36410046
28GRK61.35891002
29MAP3K111.35667718
30SMG11.34643252
31PLK11.32872749
32MST41.32657093
33NME11.25718931
34TSSK61.25069117
35TESK11.23533764
36MAP3K81.23426959
37KDR1.21694392
38DYRK31.18986003
39PASK1.17034570
40PIM11.15969455
41CDK71.14974988
42TTK1.14677559
43PAK41.14198392
44CDK81.11525242
45ILK1.11118092
46BRSK21.10130890
47ZAP701.03057178
48MAPK151.01361135
49IKBKB1.00179540
50AURKA0.94852539
51TAF10.92799636
52PAK10.87380083
53ATR0.87143771
54TGFBR10.86906204
55DAPK30.86457279
56STK40.86362005
57TYK20.83931604
58RPS6KA50.83697418
59MST1R0.83654311
60CDK40.82496589
61ACVR1B0.81156795
62IRAK40.80698495
63TAOK20.76984606
64PBK0.76417557
65FLT30.74463201
66ITK0.73827307
67ZAK0.73757872
68ERN10.73515091
69PKN20.73259274
70MARK30.72447906
71RIPK40.72116087
72TAOK30.71923585
73MKNK10.71571933
74JAK30.71168638
75CSNK2A20.70407678
76MAP2K20.70337413
77BTK0.69770661
78MAPKAPK30.68977213
79BCKDK0.68907978
80IRAK20.68416700
81CHEK20.66416869
82CLK10.66061366
83LIMK10.65661953
84PRKCI0.64988024
85CSNK2A10.63884856
86ARAF0.63269383
87EIF2AK20.62512700
88BRAF0.62442435
89TBK10.61486885
90NEK10.61223412
91CHEK10.60332972
92NLK0.60087680
93BRSK10.59896485
94MAP2K30.59858319
95TXK0.59236045
96NUAK10.58765374
97FES0.58074916
98CSF1R0.57513350
99EPHB20.56456578
100PRPF4B0.54759902
101PDK20.53035990
102SCYL20.50816543
103TEC0.50044367
104MAP3K130.48628532
105MAP3K30.48439925
106SYK0.46158481
107TNK20.45571129
108PLK30.45039130
109PRKCQ0.43723912
110MUSK0.43018818
111CDK20.41850638
112ABL20.41687178
113LYN0.41427622
114RPS6KA60.40517924
115LCK0.40151085
116RPS6KL10.39949474
117RPS6KC10.39949474
118CAMKK10.39911297
119MKNK20.39244734
120PRKCD0.39220247
121DAPK10.38865782
122KIT0.37710751
123ALK0.37589010
124MAPKAPK20.35219194
125IKBKE0.34304263
126DYRK1B0.33179438
127DYRK20.32489260
128TRIB30.31382830
129RPS6KA10.29755997

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.74675381
2DNA replication_Homo sapiens_hsa030303.79776080
3Proteasome_Homo sapiens_hsa030503.78032929
4RNA polymerase_Homo sapiens_hsa030203.45908615
5Mismatch repair_Homo sapiens_hsa034303.20453344
6Spliceosome_Homo sapiens_hsa030402.89908113
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.89432789
8Pyrimidine metabolism_Homo sapiens_hsa002402.42337186
9Homologous recombination_Homo sapiens_hsa034402.37326775
10Base excision repair_Homo sapiens_hsa034102.32179315
11RNA transport_Homo sapiens_hsa030132.26959245
12Nucleotide excision repair_Homo sapiens_hsa034202.20091423
13One carbon pool by folate_Homo sapiens_hsa006702.04013604
14Oxidative phosphorylation_Homo sapiens_hsa001901.94493876
15Parkinsons disease_Homo sapiens_hsa050121.87400936
16Sulfur relay system_Homo sapiens_hsa041221.74207140
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.68042123
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62637178
19Cell cycle_Homo sapiens_hsa041101.57412023
20Huntingtons disease_Homo sapiens_hsa050161.49850269
21Fanconi anemia pathway_Homo sapiens_hsa034601.47538847
22Protein export_Homo sapiens_hsa030601.35722287
23RNA degradation_Homo sapiens_hsa030181.30843268
24Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.29248904
25Non-homologous end-joining_Homo sapiens_hsa034501.26050612
26Primary immunodeficiency_Homo sapiens_hsa053401.24827466
27p53 signaling pathway_Homo sapiens_hsa041151.24052046
28Systemic lupus erythematosus_Homo sapiens_hsa053221.22445378
29Basal transcription factors_Homo sapiens_hsa030221.19284858
30Autoimmune thyroid disease_Homo sapiens_hsa053201.18594004
31Epstein-Barr virus infection_Homo sapiens_hsa051691.17478930
32Alzheimers disease_Homo sapiens_hsa050101.08838353
33Purine metabolism_Homo sapiens_hsa002301.08303360
34Pentose phosphate pathway_Homo sapiens_hsa000301.07908978
35Folate biosynthesis_Homo sapiens_hsa007901.06616025
36Antigen processing and presentation_Homo sapiens_hsa046121.01448687
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99490330
38Glutathione metabolism_Homo sapiens_hsa004800.85316155
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.84832449
40mRNA surveillance pathway_Homo sapiens_hsa030150.83242304
41Herpes simplex infection_Homo sapiens_hsa051680.78308573
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.77556120
43Type I diabetes mellitus_Homo sapiens_hsa049400.76302605
44Viral carcinogenesis_Homo sapiens_hsa052030.75256062
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.74427268
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.70832121
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.69318144
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63512748
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60369818
50Legionellosis_Homo sapiens_hsa051340.60315907
51Biosynthesis of amino acids_Homo sapiens_hsa012300.59999851
52Apoptosis_Homo sapiens_hsa042100.58677344
53Sulfur metabolism_Homo sapiens_hsa009200.57128719
54Measles_Homo sapiens_hsa051620.56647392
55HTLV-I infection_Homo sapiens_hsa051660.54961748
56Hematopoietic cell lineage_Homo sapiens_hsa046400.53081626
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49730793
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49699219
59Other glycan degradation_Homo sapiens_hsa005110.48287486
60Selenocompound metabolism_Homo sapiens_hsa004500.45877260
61Rheumatoid arthritis_Homo sapiens_hsa053230.45483581
62Fructose and mannose metabolism_Homo sapiens_hsa000510.44350950
63Shigellosis_Homo sapiens_hsa051310.43827542
64Asthma_Homo sapiens_hsa053100.43215571
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42933134
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42409499
67Allograft rejection_Homo sapiens_hsa053300.41849733
68Leishmaniasis_Homo sapiens_hsa051400.39602533
69Metabolic pathways_Homo sapiens_hsa011000.37723526
70Arachidonic acid metabolism_Homo sapiens_hsa005900.37492610
71Viral myocarditis_Homo sapiens_hsa054160.37266295
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36916388
73Small cell lung cancer_Homo sapiens_hsa052220.36460424
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36157665
75Carbon metabolism_Homo sapiens_hsa012000.36088263
76Tyrosine metabolism_Homo sapiens_hsa003500.35837032
77Fatty acid elongation_Homo sapiens_hsa000620.35555685
78Acute myeloid leukemia_Homo sapiens_hsa052210.35365748
79Collecting duct acid secretion_Homo sapiens_hsa049660.34990280
80Graft-versus-host disease_Homo sapiens_hsa053320.34852817
81Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.33970073
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33691371
83Phenylalanine metabolism_Homo sapiens_hsa003600.33106587
84Vitamin B6 metabolism_Homo sapiens_hsa007500.33006859
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32237086
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31505646
87Pyruvate metabolism_Homo sapiens_hsa006200.31184320
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30928861
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30181919
90Thyroid cancer_Homo sapiens_hsa052160.29139101
91N-Glycan biosynthesis_Homo sapiens_hsa005100.29062199
92Linoleic acid metabolism_Homo sapiens_hsa005910.28887635
93B cell receptor signaling pathway_Homo sapiens_hsa046620.27211600
94Regulation of autophagy_Homo sapiens_hsa041400.27137707
95Galactose metabolism_Homo sapiens_hsa000520.26748023
96Bladder cancer_Homo sapiens_hsa052190.25372623
97Hepatitis B_Homo sapiens_hsa051610.25034259
98Influenza A_Homo sapiens_hsa051640.24081412
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23825700
100Basal cell carcinoma_Homo sapiens_hsa052170.22653980
101Notch signaling pathway_Homo sapiens_hsa043300.22400864
102T cell receptor signaling pathway_Homo sapiens_hsa046600.22068539
103Cardiac muscle contraction_Homo sapiens_hsa042600.21762341
104Peroxisome_Homo sapiens_hsa041460.21735242
105HIF-1 signaling pathway_Homo sapiens_hsa040660.21400424
106Fat digestion and absorption_Homo sapiens_hsa049750.21344714
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20298968
108Phototransduction_Homo sapiens_hsa047440.19793597
109Jak-STAT signaling pathway_Homo sapiens_hsa046300.19510370
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.19101138
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19050644
112Alcoholism_Homo sapiens_hsa050340.19016688
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18848599
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.17872423
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.17334456
116Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.16471854
117Renin-angiotensin system_Homo sapiens_hsa046140.16394726
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15993910
119Staphylococcus aureus infection_Homo sapiens_hsa051500.15301749
120Arginine and proline metabolism_Homo sapiens_hsa003300.14818166
121Pertussis_Homo sapiens_hsa051330.14767776
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14753671
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14618907
124Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14410556
125Vitamin digestion and absorption_Homo sapiens_hsa049770.14312677
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13383316
127Chemical carcinogenesis_Homo sapiens_hsa052040.12581957
128Pentose and glucuronate interconversions_Homo sapiens_hsa000400.10170477

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