FAUP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.98338628
2cytidine deamination (GO:0009972)6.30228278
3cytidine metabolic process (GO:0046087)6.30228278
4cytidine catabolic process (GO:0006216)6.30228278
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.79451556
6pyrimidine ribonucleoside catabolic process (GO:0046133)5.36440580
7ribosomal small subunit assembly (GO:0000028)5.13419352
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.19010616
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.97859956
10ATP synthesis coupled proton transport (GO:0015986)3.97859956
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.88781091
12positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.83719934
13positive thymic T cell selection (GO:0045059)3.81565268
14positive T cell selection (GO:0043368)3.63129596
15sequestering of actin monomers (GO:0042989)3.61239438
16negative regulation of T cell apoptotic process (GO:0070233)3.59508263
17viral transcription (GO:0019083)3.59441954
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.50842788
19Arp2/3 complex-mediated actin nucleation (GO:0034314)3.50039183
20respiratory electron transport chain (GO:0022904)3.48838581
21translational termination (GO:0006415)3.46209819
22negative T cell selection (GO:0043383)3.46028628
23T cell migration (GO:0072678)3.45691518
24electron transport chain (GO:0022900)3.44457213
25response to interferon-beta (GO:0035456)3.42692156
26protein complex biogenesis (GO:0070271)3.40942769
27negative regulation by host of viral transcription (GO:0043922)3.40448884
28cellular response to interleukin-15 (GO:0071350)3.35742686
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.35440898
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.35440898
31positive regulation of T cell mediated cytotoxicity (GO:0001916)3.34237958
32protein neddylation (GO:0045116)3.33976902
33regulation of activation of Janus kinase activity (GO:0010533)3.32366060
34actin nucleation (GO:0045010)3.32094850
35response to pheromone (GO:0019236)3.29811741
36positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.27802905
37regulation of B cell receptor signaling pathway (GO:0050855)3.26189189
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25895598
39positive regulation of natural killer cell mediated immunity (GO:0002717)3.23941603
40translational elongation (GO:0006414)3.23359827
41positive regulation of calcium-mediated signaling (GO:0050850)3.21263413
42positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.20518976
43protein targeting to ER (GO:0045047)3.19085384
44cotranslational protein targeting to membrane (GO:0006613)3.18273410
45ribosomal small subunit biogenesis (GO:0042274)3.13341191
46positive regulation of defense response to virus by host (GO:0002230)3.11466334
47regulation of T cell mediated cytotoxicity (GO:0001914)3.10086460
48maturation of SSU-rRNA (GO:0030490)3.07548083
49pyrimidine nucleoside catabolic process (GO:0046135)3.06717557
50mast cell activation (GO:0045576)3.05975059
51protein localization to endoplasmic reticulum (GO:0070972)3.05825366
52regulation of cellular amino acid metabolic process (GO:0006521)3.04715382
53cytolysis (GO:0019835)3.03505918
54iron-sulfur cluster assembly (GO:0016226)3.00567209
55metallo-sulfur cluster assembly (GO:0031163)3.00567209
56mitochondrial respiratory chain complex assembly (GO:0033108)2.98938414
57regulation of regulatory T cell differentiation (GO:0045589)2.98543716
58establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98189171
59regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97738757
60regulation of chronic inflammatory response (GO:0002676)2.96849647
61positive regulation of interleukin-8 secretion (GO:2000484)2.94664012
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.92527800
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.92527800
64NADH dehydrogenase complex assembly (GO:0010257)2.92527800
65cytochrome complex assembly (GO:0017004)2.87841332
66T cell receptor signaling pathway (GO:0050852)2.87727070
67negative regulation of lymphocyte apoptotic process (GO:0070229)2.85435327
68purine deoxyribonucleotide catabolic process (GO:0009155)2.85309721
69positive regulation of cell killing (GO:0031343)2.85216425
70negative thymic T cell selection (GO:0045060)2.85057237
71positive regulation of gamma-delta T cell activation (GO:0046645)2.82625008
72platelet dense granule organization (GO:0060155)2.82617463
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.81126770
74thymic T cell selection (GO:0045061)2.81102930
75proteasome assembly (GO:0043248)2.80688097
76negative regulation of viral genome replication (GO:0045071)2.77891360
77regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77683916
78regulation of natural killer cell mediated immunity (GO:0002715)2.77683916
79DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77319011
80respiratory chain complex IV assembly (GO:0008535)2.76186134
81regulation of T cell receptor signaling pathway (GO:0050856)2.74142653
82mast cell activation involved in immune response (GO:0002279)2.73819913
83mast cell degranulation (GO:0043303)2.73819913
84nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.72199396
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71806860
86termination of RNA polymerase III transcription (GO:0006386)2.70255487
87transcription elongation from RNA polymerase III promoter (GO:0006385)2.70255487
88positive regulation of monocyte chemotaxis (GO:0090026)2.69742123
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.67907506
90positive regulation of alpha-beta T cell proliferation (GO:0046641)2.66638133
91regulation of cell killing (GO:0031341)2.66637083
92signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65296095
93signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65296095
94signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65296095
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.64997360
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.64997360
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.64959692
98behavioral response to nicotine (GO:0035095)2.64088111
99regulation of interleukin-8 secretion (GO:2000482)2.64045799
100regulation of T cell apoptotic process (GO:0070232)2.62550688

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.93274665
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.29889093
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.81458205
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.48160919
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.31791975
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.03303238
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00433437
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98646486
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.71229305
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.47390635
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42149075
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.38688202
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27582571
14VDR_22108803_ChIP-Seq_LS180_Human2.25109277
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.24520236
16VDR_23849224_ChIP-Seq_CD4+_Human2.21427907
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15227523
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.13746179
19ETS1_20019798_ChIP-Seq_JURKAT_Human1.98634412
20MYB_26560356_Chip-Seq_TH2_Human1.97259697
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89707668
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.87058245
23IGF1R_20145208_ChIP-Seq_DFB_Human1.75390717
24ZNF274_21170338_ChIP-Seq_K562_Hela1.72058194
25RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70697395
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.69085081
27FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67981644
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.66601033
29GATA3_26560356_Chip-Seq_TH2_Human1.66597122
30RUNX_20019798_ChIP-Seq_JUKART_Human1.61071529
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.60419806
32FOXP3_21729870_ChIP-Seq_TREG_Human1.59856959
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57987603
34GATA3_27048872_Chip-Seq_THYMUS_Human1.55895177
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54259741
36MYC_18940864_ChIP-ChIP_HL60_Human1.52492559
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49497095
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.48801740
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.48653785
40RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.45224756
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43596876
42PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.38489420
43NANOG_20526341_ChIP-Seq_ESCs_Human1.38386939
44AR_20517297_ChIP-Seq_VCAP_Human1.38097932
45EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37103508
46TP53_22573176_ChIP-Seq_HFKS_Human1.36735217
47PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.36023424
48BCL6_27268052_Chip-Seq_Bcells_Human1.31177333
49TAF2_19829295_ChIP-Seq_ESCs_Human1.30962950
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.27866619
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27866619
52EZH2_22144423_ChIP-Seq_EOC_Human1.25574599
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22336390
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20473053
55TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.19443189
56ELK1_19687146_ChIP-ChIP_HELA_Human1.17095330
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15117953
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12663886
59MYB_26560356_Chip-Seq_TH1_Human1.11940631
60P300_27268052_Chip-Seq_Bcells_Human1.10898120
61NCOR_22424771_ChIP-Seq_293T_Human1.10075053
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.09964595
63HTT_18923047_ChIP-ChIP_STHdh_Human1.08844091
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.06385688
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.06182464
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.05998564
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05687736
68MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05053743
69MYC_19829295_ChIP-Seq_ESCs_Human1.04374848
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04316687
71EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04121635
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.03752396
73CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.03437961
74SOX2_19829295_ChIP-Seq_ESCs_Human1.03367217
75NANOG_19829295_ChIP-Seq_ESCs_Human1.03367217
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.03111355
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02893537
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02331212
79ERG_20517297_ChIP-Seq_VCAP_Human1.02151649
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02023895
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01174413
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01143905
83CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99799266
84EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99439095
85ERA_21632823_ChIP-Seq_H3396_Human0.99396797
86TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99353388
87UTX_26944678_Chip-Seq_JUKART_Human0.98577925
88ELK1_22589737_ChIP-Seq_MCF10A_Human0.98557634
89CTCF_20526341_ChIP-Seq_ESCs_Human0.98403433
90FOXH1_21741376_ChIP-Seq_EPCs_Human0.97479527
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95363709
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.95196059
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94890198
94ER_23166858_ChIP-Seq_MCF-7_Human0.94762933
95RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94554659
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94500163
97P53_21459846_ChIP-Seq_SAOS-2_Human0.93967042
98SPI1_23547873_ChIP-Seq_NB4_Human0.92776602
99EWS_26573619_Chip-Seq_HEK293_Human0.91351815
100CIITA_25753668_ChIP-Seq_RAJI_Human0.90966185

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.41266712
2MP0001835_abnormal_antigen_presentation3.13359114
3MP0009785_altered_susceptibility_to2.89041176
4MP0003763_abnormal_thymus_physiology2.71554386
5MP0009379_abnormal_foot_pigmentation2.39763128
6MP0002148_abnormal_hypersensitivity_rea2.30558536
7MP0005000_abnormal_immune_tolerance2.30100735
8MP0000372_irregular_coat_pigmentation2.22640720
9MP0001800_abnormal_humoral_immune2.22474177
10MP0009333_abnormal_splenocyte_physiolog2.10444355
11MP0004147_increased_porphyrin_level2.09122127
12MP0002723_abnormal_immune_serum2.06844995
13MP0003866_abnormal_defecation2.06153793
14MP0005646_abnormal_pituitary_gland2.05030618
15MP0002837_dystrophic_cardiac_calcinosis2.02604767
16MP0002420_abnormal_adaptive_immunity1.97922336
17MP0002166_altered_tumor_susceptibility1.96640502
18MP0001819_abnormal_immune_cell1.93413015
19MP0000685_abnormal_immune_system1.89823845
20MP0005025_abnormal_response_to1.88266364
21MP0005645_abnormal_hypothalamus_physiol1.83686967
22MP0004145_abnormal_muscle_electrophysio1.81683322
23MP0003646_muscle_fatigue1.79732072
24MP0002163_abnormal_gland_morphology1.76497673
25MP0006072_abnormal_retinal_apoptosis1.73325257
26MP0001790_abnormal_immune_system1.73319192
27MP0005387_immune_system_phenotype1.73319192
28MP0002452_abnormal_antigen_presenting1.70042965
29MP0002102_abnormal_ear_morphology1.69566711
30MP0005075_abnormal_melanosome_morpholog1.62837919
31MP0008872_abnormal_physiological_respon1.56816717
32MP0000716_abnormal_immune_system1.53170025
33MP0010155_abnormal_intestine_physiology1.50999408
34MP0002398_abnormal_bone_marrow1.50744289
35MP0002006_tumorigenesis1.49476584
36MP0001968_abnormal_touch/_nociception1.43463437
37MP0006082_CNS_inflammation1.41833941
38MP0008875_abnormal_xenobiotic_pharmacok1.40583475
39MP0002138_abnormal_hepatobiliary_system1.40532268
40MP0005410_abnormal_fertilization1.40504730
41MP0003011_delayed_dark_adaptation1.39770773
42MP0002736_abnormal_nociception_after1.39196780
43MP0002876_abnormal_thyroid_physiology1.36153790
44MP0001905_abnormal_dopamine_level1.36027966
45MP0001919_abnormal_reproductive_system1.33554658
46MP0003786_premature_aging1.33060346
47MP0005084_abnormal_gallbladder_morpholo1.31833639
48MP0005389_reproductive_system_phenotype1.31423583
49MP0003724_increased_susceptibility_to1.30551603
50MP0003436_decreased_susceptibility_to1.28600367
51MP0005377_hearing/vestibular/ear_phenot1.28315814
52MP0003878_abnormal_ear_physiology1.28315814
53MP0005551_abnormal_eye_electrophysiolog1.26699306
54MP0002722_abnormal_immune_system1.24928567
55MP0001845_abnormal_inflammatory_respons1.24924182
56MP0006292_abnormal_olfactory_placode1.24897825
57MP0003195_calcinosis1.23937297
58MP0001764_abnormal_homeostasis1.23345507
59MP0000689_abnormal_spleen_morphology1.22798087
60MP0002419_abnormal_innate_immunity1.22309746
61MP0005379_endocrine/exocrine_gland_phen1.21914818
62MP0000703_abnormal_thymus_morphology1.20093172
63MP0002405_respiratory_system_inflammati1.15871321
64MP0002429_abnormal_blood_cell1.15132955
65MP0009764_decreased_sensitivity_to1.12108994
66MP0001986_abnormal_taste_sensitivity1.11697324
67MP0002933_joint_inflammation1.09474718
68MP0003806_abnormal_nucleotide_metabolis1.08932650
69MP0005253_abnormal_eye_physiology1.07572310
70MP0008469_abnormal_protein_level1.04718155
71MP0002822_catalepsy1.03074349
72MP0002277_abnormal_respiratory_mucosa1.01740646
73MP0002160_abnormal_reproductive_system1.01094766
74MP0002095_abnormal_skin_pigmentation1.01071843
75MP0001501_abnormal_sleep_pattern1.00058716
76MP0005464_abnormal_platelet_physiology0.98048039
77MP0004142_abnormal_muscle_tone0.95643465
78MP0004885_abnormal_endolymph0.94518329
79MP0002653_abnormal_ependyma_morphology0.90573107
80MP0006036_abnormal_mitochondrial_physio0.90428356
81MP0005636_abnormal_mineral_homeostasis0.84808558
82MP0006276_abnormal_autonomic_nervous0.84323170
83MP0002693_abnormal_pancreas_physiology0.83690647
84MP0001873_stomach_inflammation0.81491612
85MP0003045_fibrosis0.79697499
86MP0001765_abnormal_ion_homeostasis0.79329061
87MP0003137_abnormal_impulse_conducting0.77124669
88MP0002132_abnormal_respiratory_system0.76914692
89MP0003252_abnormal_bile_duct0.76377486
90MP0009745_abnormal_behavioral_response0.74940007
91MP0009763_increased_sensitivity_to0.74370856
92MP0008995_early_reproductive_senescence0.72677014
93MP0002234_abnormal_pharynx_morphology0.67649967
94MP0009643_abnormal_urine_homeostasis0.67265226
95MP0010386_abnormal_urinary_bladder0.67149740
96MP0002733_abnormal_thermal_nociception0.66985534
97MP0002272_abnormal_nervous_system0.66124529
98MP0003186_abnormal_redox_activity0.66090856
99MP0002638_abnormal_pupillary_reflex0.65687830
100MP0001661_extended_life_span0.65597667

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.23327555
2IgG deficiency (HP:0004315)4.18157950
3Absent rod-and cone-mediated responses on ERG (HP:0007688)4.15329237
4Abnormality of T cell number (HP:0011839)4.14861381
5Aplastic anemia (HP:0001915)4.07932521
6Mitochondrial inheritance (HP:0001427)4.05894111
7Acute necrotizing encephalopathy (HP:0006965)4.04408420
8Severe combined immunodeficiency (HP:0004430)4.02662755
9Abnormal mitochondria in muscle tissue (HP:0008316)3.74047241
103-Methylglutaconic aciduria (HP:0003535)3.67026617
11Elevated erythrocyte sedimentation rate (HP:0003565)3.62710049
12Hepatocellular necrosis (HP:0001404)3.56514741
13Increased CSF lactate (HP:0002490)3.45282270
14Hypoproteinemia (HP:0003075)3.39343822
15Progressive macrocephaly (HP:0004481)3.36215645
16Acute encephalopathy (HP:0006846)3.30086898
17Abnormality of T cells (HP:0002843)3.21916114
18Congenital stationary night blindness (HP:0007642)3.20406560
19Increased intramyocellular lipid droplets (HP:0012240)3.20379666
20Hepatic necrosis (HP:0002605)3.17932464
21Thyroiditis (HP:0100646)3.16726126
22Abnormal rod and cone electroretinograms (HP:0008323)3.13969687
23Increased hepatocellular lipid droplets (HP:0006565)3.11921544
24Combined immunodeficiency (HP:0005387)3.07042567
25Abnormality of B cell number (HP:0010975)3.06401165
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.97316827
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.97316827
28Autoimmune hemolytic anemia (HP:0001890)2.96448343
29Abnormality of eosinophils (HP:0001879)2.95272682
30Pancreatic cysts (HP:0001737)2.89238945
31Increased IgM level (HP:0003496)2.77296656
32Lipid accumulation in hepatocytes (HP:0006561)2.75473199
33Renal Fanconi syndrome (HP:0001994)2.73445159
34Cerebral edema (HP:0002181)2.67516554
35Increased muscle lipid content (HP:0009058)2.63683044
36B lymphocytopenia (HP:0010976)2.62835802
37Optic disc pallor (HP:0000543)2.54081533
38Attenuation of retinal blood vessels (HP:0007843)2.54000631
39Stomatitis (HP:0010280)2.53022855
40Eosinophilia (HP:0001880)2.49119462
41Chronic diarrhea (HP:0002028)2.46737309
42Abolished electroretinogram (ERG) (HP:0000550)2.44979686
43Abnormality of the prostate (HP:0008775)2.42320491
44Agammaglobulinemia (HP:0004432)2.41516430
45Increased serum lactate (HP:0002151)2.41067993
46Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.40621664
47Pancytopenia (HP:0001876)2.38618574
48Decreased electroretinogram (ERG) amplitude (HP:0000654)2.37087808
49Exertional dyspnea (HP:0002875)2.32155633
50True hermaphroditism (HP:0010459)2.30942568
51Constricted visual fields (HP:0001133)2.30023498
52Lactic acidosis (HP:0003128)2.29689337
53Pancreatic fibrosis (HP:0100732)2.29280574
54Cerebral palsy (HP:0100021)2.27894956
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27344684
56Autoimmune thrombocytopenia (HP:0001973)2.24257135
57Methylmalonic acidemia (HP:0002912)2.21558617
58Abnormal number of erythroid precursors (HP:0012131)2.20144019
59Type 2 muscle fiber atrophy (HP:0003554)2.16780697
60Panhypogammaglobulinemia (HP:0003139)2.15673976
61Encephalitis (HP:0002383)2.13891556
62Renal cortical cysts (HP:0000803)2.12058980
63Abnormality of T cell physiology (HP:0011840)2.10169711
64Leukocytosis (HP:0001974)2.06929000
65Abnormality of midbrain morphology (HP:0002418)2.03366092
66Molar tooth sign on MRI (HP:0002419)2.03366092
67Generalized aminoaciduria (HP:0002909)2.02632421
68Abnormality of cells of the erythroid lineage (HP:0012130)1.98968724
69Granulocytopenia (HP:0001913)1.98953762
70Abnormal delayed hypersensitivity skin test (HP:0002963)1.98814147
71Abnormality of the renal cortex (HP:0011035)1.98217392
72Myositis (HP:0100614)1.98094775
73Lethargy (HP:0001254)1.96882202
74Type I transferrin isoform profile (HP:0003642)1.96324823
75Hypoalbuminemia (HP:0003073)1.94097177
76Abnormal albumin level (HP:0012116)1.94097177
77Respiratory failure (HP:0002878)1.93609656
78Decreased central vision (HP:0007663)1.89451433
79Type II lissencephaly (HP:0007260)1.88077668
80Dynein arm defect of respiratory motile cilia (HP:0012255)1.87445296
81Absent/shortened dynein arms (HP:0200106)1.87445296
82IgM deficiency (HP:0002850)1.87281734
83Muscle fiber atrophy (HP:0100295)1.86959764
84Macrocytic anemia (HP:0001972)1.86727368
85Meningitis (HP:0001287)1.84550129
86Pustule (HP:0200039)1.84266040
87Methylmalonic aciduria (HP:0012120)1.83407071
88Aplasia/hypoplasia of the uterus (HP:0008684)1.82256575
89Exercise intolerance (HP:0003546)1.80426442
90Dicarboxylic aciduria (HP:0003215)1.79737827
91Abnormality of dicarboxylic acid metabolism (HP:0010995)1.79737827
92Pendular nystagmus (HP:0012043)1.79334585
93Severe visual impairment (HP:0001141)1.76942145
94Abnormality of urine glucose concentration (HP:0011016)1.76454058
95Glycosuria (HP:0003076)1.76454058
96Lymphopenia (HP:0001888)1.74121230
97Increased corneal curvature (HP:0100692)1.73498163
98Keratoconus (HP:0000563)1.73498163
99Abnormal glycosylation (HP:0012345)1.70652800
100Abnormal protein N-linked glycosylation (HP:0012347)1.70652800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.93204971
2KDR4.88122060
3TXK4.76945149
4MAP4K12.80436630
5BCKDK2.79920778
6TAOK32.56106045
7PASK2.46031227
8MAP4K22.27755840
9TLK12.15688740
10VRK22.14144090
11ADRBK22.10323827
12ITK2.08307941
13ZAK2.00977530
14SCYL21.97387539
15GRK11.79122765
16TEC1.57048267
17GRK61.56867573
18MAP3K121.53867933
19FES1.51621002
20LIMK11.47551044
21SYK1.45681362
22BUB11.44612688
23TESK11.40575495
24FRK1.31430579
25STK161.28596060
26NUAK11.27756676
27CAMKK11.23117113
28GRK71.22536688
29VRK11.22513833
30PRKCQ1.21621641
31CDK191.20581358
32BTK1.20428567
33MAPKAPK31.20034151
34MAP3K111.15922500
35CAMKK21.14588840
36KIT1.13414352
37IKBKB1.12521845
38ZAP701.10125276
39LCK1.07543367
40INSRR1.03004264
41MUSK1.02792829
42TNK21.00424042
43MAP2K60.93111728
44WNK40.89852351
45JAK30.89631902
46NME20.88764703
47TBK10.85967540
48LYN0.85888608
49MYLK0.85346701
50IKBKE0.85340051
51RPS6KA50.85067419
52NME10.84982619
53CSF1R0.84102866
54TRPM70.82531864
55MAP3K130.82094503
56PINK10.81008808
57MST40.79904509
58DAPK10.79434389
59RIPK40.76502021
60PIK3CG0.75162944
61OBSCN0.70513786
62TIE10.69528179
63MATK0.68257805
64ADRBK10.62110870
65PIM20.60872944
66CSK0.59050601
67IGF1R0.54402061
68OXSR10.52994343
69MAPK130.50350021
70BMPR20.49641797
71EIF2AK30.48781191
72DYRK20.46092680
73PIM10.45675780
74WNK30.45400910
75HCK0.44037432
76ERBB30.43731413
77CSNK1G30.43673789
78PIK3CA0.43396325
79AURKA0.42583307
80PRKCA0.41665073
81DAPK20.40312775
82MAPKAPK50.40243644
83MAPK150.38697123
84MAP3K140.38035174
85GRK50.37575422
86PRKACA0.35606214
87CSNK2A10.33823991
88FYN0.32832595
89PLK40.31705599
90ILK0.30500376
91LRRK20.29637003
92PRKCD0.28512692
93BMPR1B0.28464958
94CSNK2A20.27009501
95DAPK30.26837971
96ABL10.26430849
97RPS6KA40.25079779
98CAMK2A0.24997212
99MAP2K20.24383911
100ROCK10.22017261

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.40647912
2Proteasome_Homo sapiens_hsa030503.88271575
3Ribosome_Homo sapiens_hsa030103.58025333
4Oxidative phosphorylation_Homo sapiens_hsa001903.45987796
5Graft-versus-host disease_Homo sapiens_hsa053323.08708823
6Allograft rejection_Homo sapiens_hsa053302.91773713
7Parkinsons disease_Homo sapiens_hsa050122.85086485
8Autoimmune thyroid disease_Homo sapiens_hsa053202.80163818
9Antigen processing and presentation_Homo sapiens_hsa046122.73787954
10Type I diabetes mellitus_Homo sapiens_hsa049402.37917436
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.36190476
12Asthma_Homo sapiens_hsa053102.28090789
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.15237612
14RNA polymerase_Homo sapiens_hsa030202.08425769
15Hematopoietic cell lineage_Homo sapiens_hsa046401.94709856
16Alzheimers disease_Homo sapiens_hsa050101.86809123
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80975648
18Rheumatoid arthritis_Homo sapiens_hsa053231.71317021
19Huntingtons disease_Homo sapiens_hsa050161.69096689
20Protein export_Homo sapiens_hsa030601.63766783
21Phototransduction_Homo sapiens_hsa047441.61883369
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48081397
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43187776
24Cardiac muscle contraction_Homo sapiens_hsa042601.40282417
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.36176344
26Nitrogen metabolism_Homo sapiens_hsa009101.34603941
27Homologous recombination_Homo sapiens_hsa034401.32071501
28T cell receptor signaling pathway_Homo sapiens_hsa046601.29908005
29Linoleic acid metabolism_Homo sapiens_hsa005911.16350243
30Pyrimidine metabolism_Homo sapiens_hsa002401.06468044
31Viral myocarditis_Homo sapiens_hsa054161.04757778
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03189677
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02239392
34Peroxisome_Homo sapiens_hsa041460.99234712
35NF-kappa B signaling pathway_Homo sapiens_hsa040640.99103065
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99054579
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.90977796
38Olfactory transduction_Homo sapiens_hsa047400.89740613
39RNA degradation_Homo sapiens_hsa030180.89069406
40Caffeine metabolism_Homo sapiens_hsa002320.87314559
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87235072
42Staphylococcus aureus infection_Homo sapiens_hsa051500.86336702
43One carbon pool by folate_Homo sapiens_hsa006700.85870251
44Fanconi anemia pathway_Homo sapiens_hsa034600.85086207
45Systemic lupus erythematosus_Homo sapiens_hsa053220.81768004
46Retinol metabolism_Homo sapiens_hsa008300.79971390
47Chemical carcinogenesis_Homo sapiens_hsa052040.79817431
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79103467
49Purine metabolism_Homo sapiens_hsa002300.78911039
50Sulfur metabolism_Homo sapiens_hsa009200.77034091
51Collecting duct acid secretion_Homo sapiens_hsa049660.76837131
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76265955
53NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75452957
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74166737
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72158853
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72029303
57DNA replication_Homo sapiens_hsa030300.71553930
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71170545
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.69655391
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69309739
61Measles_Homo sapiens_hsa051620.68876618
62Arachidonic acid metabolism_Homo sapiens_hsa005900.67739756
63Malaria_Homo sapiens_hsa051440.62708857
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.58172717
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57423823
66Nucleotide excision repair_Homo sapiens_hsa034200.56635822
67Mismatch repair_Homo sapiens_hsa034300.54610512
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.53631736
69Spliceosome_Homo sapiens_hsa030400.53023698
70Base excision repair_Homo sapiens_hsa034100.52386167
71Leishmaniasis_Homo sapiens_hsa051400.51679443
72Tryptophan metabolism_Homo sapiens_hsa003800.49530829
73Basal transcription factors_Homo sapiens_hsa030220.48980174
74Herpes simplex infection_Homo sapiens_hsa051680.46106430
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45626865
76Metabolic pathways_Homo sapiens_hsa011000.44445411
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41849721
78Taste transduction_Homo sapiens_hsa047420.41523928
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40058986
80Butanoate metabolism_Homo sapiens_hsa006500.38531522
81Nicotine addiction_Homo sapiens_hsa050330.38317059
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.38009706
83Regulation of autophagy_Homo sapiens_hsa041400.37483735
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37349329
85Epstein-Barr virus infection_Homo sapiens_hsa051690.34466249
86Propanoate metabolism_Homo sapiens_hsa006400.33423684
87Shigellosis_Homo sapiens_hsa051310.33310896
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32309766
89Salmonella infection_Homo sapiens_hsa051320.31408659
90Ether lipid metabolism_Homo sapiens_hsa005650.30286901
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.29743123
92Salivary secretion_Homo sapiens_hsa049700.26942157
93Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26098540
94Morphine addiction_Homo sapiens_hsa050320.25555914
95Sulfur relay system_Homo sapiens_hsa041220.24872774
96Tyrosine metabolism_Homo sapiens_hsa003500.24311582
97Fat digestion and absorption_Homo sapiens_hsa049750.24073719
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.23522673
99RNA transport_Homo sapiens_hsa030130.21465693
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.21073446

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