ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.73643022
2	pyrimidine nucleobase catabolic process (GO:0006208)	5.09805913
3	negative regulation of oligodendrocyte differentiation (GO:0048715)	4.35267213
4	nucleobase catabolic process (GO:0046113)	4.25271479
5	negative regulation of axon guidance (GO:1902668)	4.01307855
6	intraciliary transport (GO:0042073)	3.95745259
7	cilium morphogenesis (GO:0060271)	3.92666642
8	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.88375793
9	regulation of development, heterochronic (GO:0040034)	3.76673419
10	DNA integration (GO:0015074)	3.71143589
11	behavioral response to ethanol (GO:0048149)	3.68722685
12	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	3.62076594
13	neural tube formation (GO:0001841)	3.61000431
14	DNA double-strand break processing (GO:0000729)	3.60641711
15	ganglion development (GO:0061548)	3.59495843
16	retinal ganglion cell axon guidance (GO:0031290)	3.57377467
17	protein polyglutamylation (GO:0018095)	3.56095754
18	transmission of nerve impulse (GO:0019226)	3.53084939
19	olfactory bulb development (GO:0021772)	3.51072673
20	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.47188846
21	glycosphingolipid biosynthetic process (GO:0006688)	3.40568310
22	vocalization behavior (GO:0071625)	3.35751272
23	positive regulation of amino acid transport (GO:0051957)	3.34545483
24	positive regulation of male gonad development (GO:2000020)	3.28865763
25	limb bud formation (GO:0060174)	3.28745154
26	nonmotile primary cilium assembly (GO:0035058)	3.27001208
27	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.25571453
28	neuron cell-cell adhesion (GO:0007158)	3.25478181
29	neuron projection extension involved in neuron projection guidance (GO:1902284)	3.22920812
30	axon extension involved in axon guidance (GO:0048846)	3.22920812
31	gamma-aminobutyric acid transport (GO:0015812)	3.19117657
32	reflex (GO:0060004)	3.15756477
33	replication fork processing (GO:0031297)	3.14027161
34	cilium organization (GO:0044782)	3.13908852
35	regulation of timing of cell differentiation (GO:0048505)	3.12728878
36	cilium assembly (GO:0042384)	3.12599192
37	microtubule severing (GO:0051013)	3.12015503
38	sympathetic nervous system development (GO:0048485)	3.08857402
39	protein localization to cilium (GO:0061512)	3.08662284
40	neuron recognition (GO:0008038)	3.08192958
41	pyrimidine dimer repair (GO:0006290)	3.05261934
42	epithelial cilium movement (GO:0003351)	3.04383385
43	regulation of cilium movement (GO:0003352)	3.03915506
44	presynaptic membrane assembly (GO:0097105)	3.03277338
45	cornea development in camera-type eye (GO:0061303)	2.99809346
46	resolution of meiotic recombination intermediates (GO:0000712)	2.99233408
47	retinal cone cell development (GO:0046549)	2.98290981
48	opioid receptor signaling pathway (GO:0038003)	2.97045665
49	synaptic vesicle maturation (GO:0016188)	2.97017262
50	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.94971296
51	glial cell proliferation (GO:0014009)	2.92082998
52	kinetochore assembly (GO:0051382)	2.90448159
53	smoothened signaling pathway (GO:0007224)	2.89054329
54	regulation of male gonad development (GO:2000018)	2.87204995
55	startle response (GO:0001964)	2.86678338
56	regulation of feeding behavior (GO:0060259)	2.86335512
57	spinal cord association neuron differentiation (GO:0021527)	2.85670308
58	hippocampus development (GO:0021766)	2.85379409
59	establishment of mitochondrion localization (GO:0051654)	2.84576168
60	cell proliferation in forebrain (GO:0021846)	2.82140947
61	synapse assembly (GO:0007416)	2.74895357
62	regulation of oligodendrocyte differentiation (GO:0048713)	2.74655371
63	somite development (GO:0061053)	2.73750538
64	C4-dicarboxylate transport (GO:0015740)	2.73049251
65	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.72615013
66	adaptation of signaling pathway (GO:0023058)	2.71434842
67	photoreceptor cell maintenance (GO:0045494)	2.71191364
68	neuron fate commitment (GO:0048663)	2.70613687
69	axonal fasciculation (GO:0007413)	2.70606152
70	acrosome assembly (GO:0001675)	2.70470742
71	microtubule depolymerization (GO:0007019)	2.70091977
72	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.69735321
73	meiotic chromosome segregation (GO:0045132)	2.67987893
74	homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)	2.66384028
75	DNA replication-dependent nucleosome organization (GO:0034723)	2.64038530
76	DNA replication-dependent nucleosome assembly (GO:0006335)	2.64038530
77	appendage development (GO:0048736)	2.63070482
78	limb development (GO:0060173)	2.63070482
79	negative chemotaxis (GO:0050919)	2.60787782
80	forebrain neuron differentiation (GO:0021879)	2.59059049
81	cerebral cortex radially oriented cell migration (GO:0021799)	2.58861545
82	histone H2A acetylation (GO:0043968)	2.58746046
83	somite rostral/caudal axis specification (GO:0032525)	2.55938691
84	L-fucose metabolic process (GO:0042354)	2.55846786
85	L-fucose catabolic process (GO:0042355)	2.55846786
86	fucose catabolic process (GO:0019317)	2.55846786
87	positive regulation of growth hormone secretion (GO:0060124)	2.54592310
88	kinetochore organization (GO:0051383)	2.53931357
89	proximal/distal pattern formation (GO:0009954)	2.53386039
90	axoneme assembly (GO:0035082)	2.52553738
91	cell differentiation in spinal cord (GO:0021515)	2.51001763
92	photoreceptor cell development (GO:0042461)	2.50378337
93	regulation of axon guidance (GO:1902667)	2.48984964
94	spinal cord development (GO:0021510)	2.48875343
95	ubiquinone metabolic process (GO:0006743)	2.46999584
96	cerebral cortex cell migration (GO:0021795)	2.46323337
97	cilium movement (GO:0003341)	2.45270939
98	cAMP catabolic process (GO:0006198)	2.44415061
99	neuronal action potential propagation (GO:0019227)	2.43836040
100	cerebral cortex neuron differentiation (GO:0021895)	2.43633411

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	4.23765589
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.07580415
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.58415165
4	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.46923664
5	GBX2_23144817_ChIP-Seq_PC3_Human	3.42641289
6	VDR_22108803_ChIP-Seq_LS180_Human	3.12714835
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.86429594
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.85426392
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.59025234
10	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.51130126
11	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42365768
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.37315501
13	FUS_26573619_Chip-Seq_HEK293_Human	2.34632216
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.31694364
15	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.17941864
16	P300_19829295_ChIP-Seq_ESCs_Human	2.11647455
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.11086036
18	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.09579756
19	IRF1_19129219_ChIP-ChIP_H3396_Human	2.06658615
20	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.02842689
21	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.95489392
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90530506
23	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.83398798
24	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.81761685
25	EWS_26573619_Chip-Seq_HEK293_Human	1.79836435
26	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.78176268
27	SMAD4_21799915_ChIP-Seq_A2780_Human	1.71494284
28	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.65808352
29	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.65249385
30	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.63462027
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59633464
32	STAT3_23295773_ChIP-Seq_U87_Human	1.59242664
33	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.59138728
34	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.58126884
35	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56270198
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.49134936
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.49134936
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48795096
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45239562
40	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45013908
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43082122
42	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.43079364
43	ER_23166858_ChIP-Seq_MCF-7_Human	1.40991711
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39964391
45	REST_21632747_ChIP-Seq_MESCs_Mouse	1.39134122
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37625959
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.35431606
48	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35341697
49	RUNX2_22187159_ChIP-Seq_PCA_Human	1.35259477
50	AR_25329375_ChIP-Seq_VCAP_Human	1.33953030
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.33433746
52	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.31536505
53	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31183032
54	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31183032
55	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.29635090
56	TCF4_23295773_ChIP-Seq_U87_Human	1.29372409
57	BCAT_22108803_ChIP-Seq_LS180_Human	1.27794769
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.26270740
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.25433374
60	AR_21572438_ChIP-Seq_LNCaP_Human	1.24299291
61	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22912910
62	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.22758497
63	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.17002148
64	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.15355608
65	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.15001104
66	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.14990261
67	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.14203421
68	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.14030821
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12472654
70	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.10500003
71	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09250473
72	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.06536910
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06353588
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06353588
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.05893884
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04468899
77	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.04020820
78	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.03185669
79	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.02179890
80	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01701946
81	JUN_21703547_ChIP-Seq_K562_Human	1.01448626
82	TP53_16413492_ChIP-PET_HCT116_Human	1.00091094
83	LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98429696
84	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.98350894
85	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.97764197
86	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.97647114
87	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.96352678
88	ELK1_19687146_ChIP-ChIP_HELA_Human	0.96206244
89	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.96203887
90	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.95746942
91	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.95659179
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.94837805
93	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94739230
94	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.94558753
95	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.94356778
96	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.93897466
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.93744088
98	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.93274938
99	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.91099527
100	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	0.90939872

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008789_abnormal_olfactory_epithelium	3.55560474
2	MP0003122_maternal_imprinting	3.26353093
3	MP0005394_taste/olfaction_phenotype	3.20067513
4	MP0005499_abnormal_olfactory_system	3.20067513
5	MP0001984_abnormal_olfaction	2.61639287
6	MP0001529_abnormal_vocalization	2.58761640
7	MP0006292_abnormal_olfactory_placode	2.50088035
8	MP0006072_abnormal_retinal_apoptosis	2.34201687
9	MP0002736_abnormal_nociception_after	2.13432334
10	MP0003880_abnormal_central_pattern	2.13001841
11	MP0003787_abnormal_imprinting	2.11264219
12	MP0000049_abnormal_middle_ear	2.10153476
13	MP0005253_abnormal_eye_physiology	2.04691346
14	MP0001968_abnormal_touch/_nociception	2.03781884
15	MP0000778_abnormal_nervous_system	1.96067643
16	MP0003121_genomic_imprinting	1.95850922
17	MP0000631_abnormal_neuroendocrine_gland	1.95599529
18	MP0002653_abnormal_ependyma_morphology	1.95099640
19	MP0004133_heterotaxia	1.84266813
20	MP0004142_abnormal_muscle_tone	1.76949842
21	MP0002751_abnormal_autonomic_nervous	1.69355679
22	MP0002102_abnormal_ear_morphology	1.68968409
23	MP0000566_synostosis	1.68456611
24	MP0002233_abnormal_nose_morphology	1.66898015
25	MP0000372_irregular_coat_pigmentation	1.60882439
26	MP0001293_anophthalmia	1.54400016
27	MP0002938_white_spotting	1.54396446
28	MP0005171_absent_coat_pigmentation	1.51886589
29	MP0003938_abnormal_ear_development	1.51708164
30	MP0005248_abnormal_Harderian_gland	1.50591973
31	MP0003937_abnormal_limbs/digits/tail_de	1.48042312
32	MP0006276_abnormal_autonomic_nervous	1.47624796
33	MP0002557_abnormal_social/conspecific_i	1.44272765
34	MP0009745_abnormal_behavioral_response	1.43895991
35	MP0004043_abnormal_pH_regulation	1.43645350
36	MP0002272_abnormal_nervous_system	1.40592008
37	MP0002095_abnormal_skin_pigmentation	1.39202325
38	MP0005645_abnormal_hypothalamus_physiol	1.38996604
39	MP0001986_abnormal_taste_sensitivity	1.38517737
40	MP0004147_increased_porphyrin_level	1.37514125
41	MP0003635_abnormal_synaptic_transmissio	1.37431449
42	MP0006054_spinal_hemorrhage	1.35082508
43	MP0003755_abnormal_palate_morphology	1.34150052
44	MP0002184_abnormal_innervation	1.33432588
45	MP0008058_abnormal_DNA_repair	1.29559664
46	MP0005551_abnormal_eye_electrophysiolog	1.29185927
47	MP0002735_abnormal_chemical_nociception	1.27502531
48	MP0002572_abnormal_emotion/affect_behav	1.27081088
49	MP0002254_reproductive_system_inflammat	1.25000376
50	MP0001486_abnormal_startle_reflex	1.22603383
51	MP0003136_yellow_coat_color	1.22588690
52	MP0005379_endocrine/exocrine_gland_phen	1.22155190
53	MP0002163_abnormal_gland_morphology	1.22112989
54	MP0004270_analgesia	1.17885783
55	MP0000955_abnormal_spinal_cord	1.17162711
56	MP0002063_abnormal_learning/memory/cond	1.16888724
57	MP0000383_abnormal_hair_follicle	1.15982421
58	MP0005391_vision/eye_phenotype	1.14535442
59	MP0008877_abnormal_DNA_methylation	1.12566943
60	MP0002234_abnormal_pharynx_morphology	1.11294752
61	MP0004811_abnormal_neuron_physiology	1.10833493
62	MP0001188_hyperpigmentation	1.10033615
63	MP0002064_seizures	1.08331825
64	MP0000026_abnormal_inner_ear	1.04815686
65	MP0002067_abnormal_sensory_capabilities	1.04807857
66	MP0003646_muscle_fatigue	1.03732991
67	MP0009046_muscle_twitch	1.03267941
68	MP0002733_abnormal_thermal_nociception	1.02144903
69	MP0008995_early_reproductive_senescence	1.01874380
70	MP0003861_abnormal_nervous_system	1.01133546
71	MP0001764_abnormal_homeostasis	1.00860702
72	MP0004859_abnormal_synaptic_plasticity	1.00659425
73	MP0009780_abnormal_chondrocyte_physiolo	1.00525120
74	MP0002882_abnormal_neuron_morphology	1.00482162
75	MP0002752_abnormal_somatic_nervous	1.00099776
76	MP0002734_abnormal_mechanical_nocicepti	0.99356655
77	MP0003567_abnormal_fetal_cardiomyocyte	0.98895629
78	MP0002909_abnormal_adrenal_gland	0.96036238
79	MP0003011_delayed_dark_adaptation	0.94975653
80	MP0001970_abnormal_pain_threshold	0.93069477
81	MP0002822_catalepsy	0.91698486
82	MP0000015_abnormal_ear_pigmentation	0.91675330
83	MP0004885_abnormal_endolymph	0.91379765
84	MP0001299_abnormal_eye_distance/	0.90528641
85	MP0003385_abnormal_body_wall	0.88575258
86	MP0003137_abnormal_impulse_conducting	0.88123735
87	MP0000569_abnormal_digit_pigmentation	0.85472125
88	MP0003698_abnormal_male_reproductive	0.85165526
89	MP0002152_abnormal_brain_morphology	0.84576599
90	MP0000427_abnormal_hair_cycle	0.83316834
91	MP0001963_abnormal_hearing_physiology	0.83156191
92	MP0000639_abnormal_adrenal_gland	0.82527942
93	MP0004924_abnormal_behavior	0.80972500
94	MP0005386_behavior/neurological_phenoty	0.80972500
95	MP0005195_abnormal_posterior_eye	0.80782531
96	MP0003119_abnormal_digestive_system	0.80716363
97	MP0002210_abnormal_sex_determination	0.78398767
98	MP0001501_abnormal_sleep_pattern	0.78332667
99	MP0000647_abnormal_sebaceous_gland	0.78252245
100	MP0004134_abnormal_chest_morphology	0.77912519

Predicted human phenotypes

Rank	Gene Set	Z-score
1	True hermaphroditism (HP:0010459)	5.14265184
2	Pancreatic cysts (HP:0001737)	4.31790004
3	Pancreatic fibrosis (HP:0100732)	4.10281051
4	Nephronophthisis (HP:0000090)	3.53629321
5	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.39048755
6	Colon cancer (HP:0003003)	3.36756763
7	Medial flaring of the eyebrow (HP:0010747)	3.32719015
8	Gait imbalance (HP:0002141)	3.27321887
9	Broad alveolar ridges (HP:0000187)	3.15979741
10	Molar tooth sign on MRI (HP:0002419)	3.14633241
11	Abnormality of midbrain morphology (HP:0002418)	3.14633241
12	Congenital primary aphakia (HP:0007707)	3.09576814
13	Occipital encephalocele (HP:0002085)	3.04732577
14	Postaxial foot polydactyly (HP:0001830)	3.00359295
15	Nephrogenic diabetes insipidus (HP:0009806)	2.94112067
16	Abnormal biliary tract physiology (HP:0012439)	2.93577270
17	Bile duct proliferation (HP:0001408)	2.93577270
18	Cystic liver disease (HP:0006706)	2.93263207
19	Abnormality of the renal medulla (HP:0100957)	2.90679478
20	Polyphagia (HP:0002591)	2.89425871
21	Absent speech (HP:0001344)	2.83013019
22	Retinal dysplasia (HP:0007973)	2.81655133
23	Vaginal atresia (HP:0000148)	2.66231858
24	Genital tract atresia (HP:0001827)	2.66120227
25	Lissencephaly (HP:0001339)	2.65516836
26	Type II lissencephaly (HP:0007260)	2.63451256
27	Tubulointerstitial nephritis (HP:0001970)	2.58300427
28	Facial hemangioma (HP:0000329)	2.58149391
29	Chronic hepatic failure (HP:0100626)	2.57859606
30	Sclerocornea (HP:0000647)	2.56083238
31	Hepatoblastoma (HP:0002884)	2.55577549
32	Hyperventilation (HP:0002883)	2.53398900
33	Tented upper lip vermilion (HP:0010804)	2.52395895
34	Postaxial hand polydactyly (HP:0001162)	2.47072585
35	Preaxial hand polydactyly (HP:0001177)	2.43528777
36	Abnormality of the ileum (HP:0001549)	2.40542330
37	Oligodactyly (hands) (HP:0001180)	2.38195107
38	Broad foot (HP:0001769)	2.36194127
39	Anencephaly (HP:0002323)	2.32338518
40	Congenital hepatic fibrosis (HP:0002612)	2.30778655
41	Male pseudohermaphroditism (HP:0000037)	2.29294292
42	Meckel diverticulum (HP:0002245)	2.28848352
43	Hemiparesis (HP:0001269)	2.26423197
44	Hypoplastic pelvis (HP:0008839)	2.21424926
45	Hyperglycinemia (HP:0002154)	2.19542696
46	Astigmatism (HP:0000483)	2.17146429
47	Oligodactyly (HP:0012165)	2.16805070
48	Drooling (HP:0002307)	2.14097490
49	Focal motor seizures (HP:0011153)	2.13150519
50	Pendular nystagmus (HP:0012043)	2.11419584
51	Supernumerary spleens (HP:0009799)	2.11242970
52	Aganglionic megacolon (HP:0002251)	2.10366973
53	Narrow forehead (HP:0000341)	2.06665611
54	Abnormality of the labia minora (HP:0012880)	2.05148600
55	Neonatal respiratory distress (HP:0002643)	2.04450827
56	Epidermoid cyst (HP:0200040)	2.04288537
57	Hip dysplasia (HP:0001385)	2.04106619
58	Amyotrophic lateral sclerosis (HP:0007354)	2.03621829
59	Thyroid-stimulating hormone excess (HP:0002925)	2.02676711
60	Abnormality of the metopic suture (HP:0005556)	2.01971235
61	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.01337626
62	Optic nerve hypoplasia (HP:0000609)	2.00386190
63	Oculomotor apraxia (HP:0000657)	2.00307957
64	Agitation (HP:0000713)	1.99965385
65	Abnormality of the astrocytes (HP:0100707)	1.99502063
66	Astrocytoma (HP:0009592)	1.99502063
67	Congenital stationary night blindness (HP:0007642)	1.96370830
68	Renal hypoplasia (HP:0000089)	1.96100919
69	Hyperglycinuria (HP:0003108)	1.94612855
70	Poor coordination (HP:0002370)	1.92177112
71	Pachygyria (HP:0001302)	1.91895795
72	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.91664541
73	Excessive salivation (HP:0003781)	1.91538507
74	Limb dystonia (HP:0002451)	1.90526972
75	Specific learning disability (HP:0001328)	1.89373860
76	Dandy-Walker malformation (HP:0001305)	1.89355955
77	Anophthalmia (HP:0000528)	1.89322998
78	Volvulus (HP:0002580)	1.86590377
79	Intestinal atresia (HP:0011100)	1.86279829
80	Short foot (HP:0001773)	1.85282025
81	Sloping forehead (HP:0000340)	1.85234151
82	Decreased testicular size (HP:0008734)	1.85194780
83	Cerebellar dysplasia (HP:0007033)	1.81170684
84	Intellectual disability, moderate (HP:0002342)	1.81074332
85	Abnormality of serine family amino acid metabolism (HP:0010894)	1.80373274
86	Abnormality of glycine metabolism (HP:0010895)	1.80373274
87	Multicystic kidney dysplasia (HP:0000003)	1.79049607
88	Micropenis (HP:0000054)	1.77878246
89	Renal dysplasia (HP:0000110)	1.77270138
90	Abnormal eating behavior (HP:0100738)	1.76272799
91	Attenuation of retinal blood vessels (HP:0007843)	1.76167801
92	Tubular atrophy (HP:0000092)	1.75463258
93	Methylmalonic acidemia (HP:0002912)	1.74422397
94	Abnormality of the renal cortex (HP:0011035)	1.74407843
95	Fibular aplasia (HP:0002990)	1.73915846
96	Prominent nasal bridge (HP:0000426)	1.73720405
97	Decreased central vision (HP:0007663)	1.72229426
98	Febrile seizures (HP:0002373)	1.71888825
99	Tubulointerstitial abnormality (HP:0001969)	1.71793277
100	Bifid tongue (HP:0010297)	1.71154734

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.97908616
2	MAP3K4	3.55791472
3	WNK3	3.52745567
4	FRK	3.24249119
5	MAP2K7	3.10749197
6	CASK	2.85078868
7	MAP4K2	2.78306778
8	PINK1	2.77078028
9	EPHA4	2.69495004
10	TRIM28	2.67104475
11	STK38L	2.62231223
12	BMPR1B	2.53096923
13	SRPK1	2.47991886
14	DYRK3	2.00451390
15	MAPK13	1.97969590
16	BCR	1.91236046
17	MKNK1	1.80103888
18	TNIK	1.67692459
19	MKNK2	1.65051921
20	CSNK1G3	1.61324964
21	CSNK1A1L	1.57220147
22	DYRK2	1.56267348
23	PAK3	1.50896009
24	RPS6KA4	1.44963952
25	CSNK1G2	1.38607837
26	CDK19	1.38261564
27	BRSK2	1.32371579
28	CSNK1G1	1.32242960
29	NTRK2	1.29921485
30	BRD4	1.26358868
31	MAP2K4	1.23040579
32	MAP3K9	1.17497822
33	PRKCG	1.16408797
34	EPHA3	1.16224299
35	CCNB1	1.14821967
36	ACVR1B	1.11539049
37	ADRBK2	1.09970788
38	GRK1	1.04557954
39	PAK6	1.03642030
40	PRKCE	1.01515872
41	MAP3K6	0.98049999
42	AKT3	0.95899795
43	MINK1	0.95122772
44	PKN2	0.93392695
45	CAMKK2	0.92085196
46	ZAK	0.87178866
47	DYRK1A	0.83286778
48	PLK2	0.80974129
49	NUAK1	0.78912176
50	BCKDK	0.78385879
51	CDC7	0.72953921
52	NTRK3	0.72058457
53	PKN1	0.68271439
54	NEK1	0.67238490
55	BRSK1	0.66500582
56	EPHB2	0.63733761
57	PLK1	0.61667776
58	TGFBR1	0.60222836
59	PHKG1	0.57907110
60	PHKG2	0.57907110
61	ERBB3	0.57588051
62	OXSR1	0.57229087
63	STK38	0.57151211
64	DYRK1B	0.56878314
65	ERBB2	0.56840827
66	CDK3	0.54657497
67	FER	0.54599460
68	IRAK1	0.53497927
69	UHMK1	0.53193495
70	FLT3	0.53010905
71	ATM	0.52809805
72	CAMK2A	0.52294143
73	CDK5	0.48340854
74	CHEK2	0.47380422
75	PRKAA1	0.47279971
76	FGFR2	0.45691716
77	WNK4	0.45492168
78	TIE1	0.45198707
79	PLK3	0.45077529
80	VRK1	0.44874931
81	STK39	0.43540827
82	PRKACA	0.43536453
83	PRKACB	0.42206322
84	PLK4	0.41910833
85	CAMK2D	0.41173366
86	CAMK4	0.41140828
87	INSRR	0.40805576
88	CDK14	0.40731482
89	ATR	0.40093104
90	CDK18	0.37661745
91	CDK11A	0.35280134
92	CAMK2B	0.35119279
93	CSNK1D	0.34730620
94	SGK223	0.34648736
95	SGK494	0.34648736
96	CDK15	0.33997786
97	PRKCZ	0.33578584
98	RPS6KA5	0.30804677
99	KSR1	0.28852809
100	SGK2	0.28284933

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	4.27857991
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.28334570
3	Fanconi anemia pathway_Homo sapiens_hsa03460	3.11317438
4	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.08166102
5	Butanoate metabolism_Homo sapiens_hsa00650	2.92659664
6	Nicotine addiction_Homo sapiens_hsa05033	2.77466492
7	Steroid biosynthesis_Homo sapiens_hsa00100	2.40284934
8	Propanoate metabolism_Homo sapiens_hsa00640	2.26356188
9	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.02844617
10	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.97348550
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96128608
12	GABAergic synapse_Homo sapiens_hsa04727	1.88782692
13	Protein export_Homo sapiens_hsa03060	1.79189385
14	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.69772912
15	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.66523457
16	Taste transduction_Homo sapiens_hsa04742	1.62004919
17	Morphine addiction_Homo sapiens_hsa05032	1.61032477
18	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.60579182
19	Basal transcription factors_Homo sapiens_hsa03022	1.44576816
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.42749467
21	Glutamatergic synapse_Homo sapiens_hsa04724	1.32783950
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.32123110
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.31310159
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.31279041
25	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.28971995
26	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.28048270
27	Non-homologous end-joining_Homo sapiens_hsa03450	1.27014576
28	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.24741207
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21918875
30	Axon guidance_Homo sapiens_hsa04360	1.20658202
31	RNA degradation_Homo sapiens_hsa03018	1.20458579
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.19764533
33	Tryptophan metabolism_Homo sapiens_hsa00380	1.19758421
34	Fatty acid metabolism_Homo sapiens_hsa01212	1.18874148
35	Base excision repair_Homo sapiens_hsa03410	1.18309780
36	Circadian entrainment_Homo sapiens_hsa04713	1.14197753
37	Homologous recombination_Homo sapiens_hsa03440	1.13526191
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.13515163
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09447365
40	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.08513228
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.07363887
42	Phototransduction_Homo sapiens_hsa04744	1.02996302
43	Basal cell carcinoma_Homo sapiens_hsa05217	1.01705574
44	Peroxisome_Homo sapiens_hsa04146	0.98578799
45	Olfactory transduction_Homo sapiens_hsa04740	0.98566681
46	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.94110802
47	RNA polymerase_Homo sapiens_hsa03020	0.92667356
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.91701157
49	Spliceosome_Homo sapiens_hsa03040	0.91233963
50	ABC transporters_Homo sapiens_hsa02010	0.89364316
51	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.88640944
52	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.87968534
53	Arginine and proline metabolism_Homo sapiens_hsa00330	0.86604758
54	Lysine degradation_Homo sapiens_hsa00310	0.85948268
55	Dopaminergic synapse_Homo sapiens_hsa04728	0.84102434
56	Serotonergic synapse_Homo sapiens_hsa04726	0.80122376
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.77883540
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76024449
59	Fatty acid degradation_Homo sapiens_hsa00071	0.73917412
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68066998
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.67850708
62	Purine metabolism_Homo sapiens_hsa00230	0.66795937
63	Oxidative phosphorylation_Homo sapiens_hsa00190	0.65172602
64	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.64798637
65	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.63195045
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62979326
67	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.62894904
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61787942
69	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.61243314
70	Retinol metabolism_Homo sapiens_hsa00830	0.60821141
71	Mismatch repair_Homo sapiens_hsa03430	0.59725544
72	Oocyte meiosis_Homo sapiens_hsa04114	0.57777729
73	Metabolic pathways_Homo sapiens_hsa01100	0.57404377
74	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.57323206
75	Long-term depression_Homo sapiens_hsa04730	0.56767181
76	Regulation of autophagy_Homo sapiens_hsa04140	0.56379535
77	Sphingolipid metabolism_Homo sapiens_hsa00600	0.53396639
78	Insulin secretion_Homo sapiens_hsa04911	0.53356871
79	Salivary secretion_Homo sapiens_hsa04970	0.52733828
80	Caffeine metabolism_Homo sapiens_hsa00232	0.51934002
81	Folate biosynthesis_Homo sapiens_hsa00790	0.51273140
82	Hippo signaling pathway_Homo sapiens_hsa04390	0.50300364
83	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.49641488
84	RNA transport_Homo sapiens_hsa03013	0.46215822
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45708643
86	Circadian rhythm_Homo sapiens_hsa04710	0.43294077
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.43163964
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.43087732
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42187287
90	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42117704
91	Calcium signaling pathway_Homo sapiens_hsa04020	0.41894728
92	Carbon metabolism_Homo sapiens_hsa01200	0.41855441
93	Fatty acid elongation_Homo sapiens_hsa00062	0.39503501
94	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38716293
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.38608759
96	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37809826
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.37248311
98	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37152362
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.35248786
100	Amphetamine addiction_Homo sapiens_hsa05031	0.35174827

FAUP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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