ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	blood coagulation, intrinsic pathway (GO:0007597)	5.72157510
2	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	5.07238484
3	thrombin receptor signaling pathway (GO:0070493)	4.63397323
4	regulation of lipoprotein metabolic process (GO:0050746)	4.37554566
5	regulation of integrin-mediated signaling pathway (GO:2001044)	3.91224698
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	3.91208857
7	L-phenylalanine catabolic process (GO:0006559)	3.91208857
8	regulation of platelet aggregation (GO:0090330)	3.81449093
9	oxygen transport (GO:0015671)	3.80480758
10	regulation of platelet activation (GO:0010543)	3.77453645
11	gas transport (GO:0015669)	3.74127279
12	positive regulation of blood coagulation (GO:0030194)	3.73362499
13	positive regulation of hemostasis (GO:1900048)	3.73362499
14	exogenous drug catabolic process (GO:0042738)	3.72095681
15	low-density lipoprotein particle remodeling (GO:0034374)	3.62952357
16	fibrinolysis (GO:0042730)	3.58459717
17	high-density lipoprotein particle remodeling (GO:0034375)	3.51519578
18	neutrophil activation involved in immune response (GO:0002283)	3.50355955
19	drug catabolic process (GO:0042737)	3.50213018
20	negative regulation of macrophage derived foam cell differentiation (GO:0010745)	3.47901433
21	reverse cholesterol transport (GO:0043691)	3.47030921
22	leukocyte migration involved in inflammatory response (GO:0002523)	3.44213846
23	positive regulation of coagulation (GO:0050820)	3.41447434
24	adenosine receptor signaling pathway (GO:0001973)	3.29687626
25	protein neddylation (GO:0045116)	3.26779634
26	negative regulation of protein localization to cell surface (GO:2000009)	3.24779933
27	regulation of triglyceride catabolic process (GO:0010896)	3.24106360
28	peptidyl-glutamic acid carboxylation (GO:0017187)	3.22232802
29	protein carboxylation (GO:0018214)	3.22232802
30	positive regulation of endothelial cell differentiation (GO:0045603)	3.20262514
31	negative regulation of norepinephrine secretion (GO:0010700)	3.18141850
32	regulation of female receptivity (GO:0045924)	3.17144127
33	negative regulation of blood coagulation (GO:0030195)	3.16588102
34	negative regulation of hemostasis (GO:1900047)	3.16588102
35	negative regulation of platelet activation (GO:0010544)	3.13158675
36	angiogenesis involved in wound healing (GO:0060055)	3.10549735
37	platelet aggregation (GO:0070527)	3.09526441
38	ethanol oxidation (GO:0006069)	3.09329170
39	L-phenylalanine metabolic process (GO:0006558)	3.06372349
40	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	3.06372349
41	negative regulation of heart rate (GO:0010459)	3.01272536
42	negative regulation of appetite (GO:0032099)	3.00752856
43	negative regulation of response to food (GO:0032096)	3.00752856
44	autophagic vacuole fusion (GO:0000046)	2.99933996
45	epoxygenase P450 pathway (GO:0019373)	2.97625589
46	phospholipid homeostasis (GO:0055091)	2.96126568
47	regulation of protein activation cascade (GO:2000257)	2.92757813
48	regulation of complement activation (GO:0030449)	2.87535673
49	regulation of hemostasis (GO:1900046)	2.85210869
50	regulation of blood coagulation (GO:0030193)	2.85210869
51	tyrosine metabolic process (GO:0006570)	2.83894624
52	platelet degranulation (GO:0002576)	2.82666128
53	regulation of macrophage derived foam cell differentiation (GO:0010743)	2.81429017
54	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.80349381
55	protein-lipid complex remodeling (GO:0034368)	2.77368185
56	macromolecular complex remodeling (GO:0034367)	2.77368185
57	plasma lipoprotein particle remodeling (GO:0034369)	2.77368185
58	protoporphyrinogen IX metabolic process (GO:0046501)	2.75790227
59	positive regulation of mast cell activation (GO:0033005)	2.75438024
60	negative regulation of coagulation (GO:0050819)	2.73801723
61	protein activation cascade (GO:0072376)	2.72440864
62	aromatic amino acid family catabolic process (GO:0009074)	2.71605035
63	female mating behavior (GO:0060180)	2.69696267
64	positive regulation of systemic arterial blood pressure (GO:0003084)	2.67461761
65	amino-acid betaine metabolic process (GO:0006577)	2.66091984
66	acylglycerol homeostasis (GO:0055090)	2.63394296
67	triglyceride homeostasis (GO:0070328)	2.63394296
68	regulation of endothelial cell differentiation (GO:0045601)	2.59733447
69	complement activation, alternative pathway (GO:0006957)	2.58602579
70	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.55611470
71	regulation of coagulation (GO:0050818)	2.54985401
72	hemoglobin metabolic process (GO:0020027)	2.53306871
73	cellular biogenic amine catabolic process (GO:0042402)	2.53227975
74	amine catabolic process (GO:0009310)	2.53227975
75	negative regulation of wound healing (GO:0061045)	2.53143988
76	negative regulation of heart contraction (GO:0045822)	2.50699553
77	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.49969521
78	bile acid and bile salt transport (GO:0015721)	2.49126044
79	dopamine transport (GO:0015872)	2.46395408
80	regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)	2.41061629
81	megakaryocyte development (GO:0035855)	2.39993294
82	fusion of sperm to egg plasma membrane (GO:0007342)	2.39967143
83	regulation of cholesterol esterification (GO:0010872)	2.39799551
84	positive regulation of wound healing (GO:0090303)	2.39572445
85	ethanol metabolic process (GO:0006067)	2.39552052
86	negative regulation of protein activation cascade (GO:2000258)	2.35087011
87	axon ensheathment in central nervous system (GO:0032291)	2.34398245
88	central nervous system myelination (GO:0022010)	2.34398245
89	negative regulation of homotypic cell-cell adhesion (GO:0034111)	2.33527474
90	regulation of norepinephrine secretion (GO:0014061)	2.33038496
91	extracellular fibril organization (GO:0043206)	2.32956008
92	positive regulation of triglyceride lipase activity (GO:0061365)	2.32067834
93	positive regulation of lipoprotein lipase activity (GO:0051006)	2.32067834
94	platelet activation (GO:0030168)	2.31394017
95	omega-hydroxylase P450 pathway (GO:0097267)	2.31229782
96	lipoxygenase pathway (GO:0019372)	2.30423384
97	S-adenosylmethionine metabolic process (GO:0046500)	2.29765644
98	positive regulation of inositol phosphate biosynthetic process (GO:0060732)	2.29264810
99	drug metabolic process (GO:0017144)	2.28196045
100	negative regulation of complement activation (GO:0045916)	2.27903370

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.33219409
2	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	3.16104732
3	GATA1_19941826_ChIP-Seq_K562_Human	2.78298919
4	GATA1_22025678_ChIP-Seq_K562_Human	2.62987594
5	SCL_19346495_ChIP-Seq_HPC-7_Human	2.52580038
6	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	2.49711403
7	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	2.10761560
8	GATA2_19941826_ChIP-Seq_K562_Human	2.08660196
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.07193290
10	GATA1_19941827_ChIP-Seq_MEL_Mouse	2.04869557
11	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.99149911
12	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.84556113
13	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.82608057
14	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.81865503
15	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.77564348
16	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.72807157
17	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.64564703
18	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.59036453
19	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	1.55003681
20	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	1.51613447
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.51166346
22	DROSHA_22980978_ChIP-Seq_HELA_Human	1.48324259
23	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.46274387
24	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.42023377
25	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.40983069
26	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.33271920
27	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.31379066
28	TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse	1.25393708
29	HTT_18923047_ChIP-ChIP_STHdh_Human	1.24794947
30	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.24781161
31	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.23332131
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.19774455
33	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.16769907
34	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.14853758
35	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.14352930
36	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.12877341
37	SPI1_23127762_ChIP-Seq_K562_Human	1.11752202
38	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.10539441
39	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.10300557
40	VDR_22108803_ChIP-Seq_LS180_Human	1.10072962
41	AR_21572438_ChIP-Seq_LNCaP_Human	1.07856101
42	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.07264513
43	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.06945547
44	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.05802795
45	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.04720004
46	ELK4_26923725_Chip-Seq_MESODERM_Mouse	1.02946080
47	GATA1_19941827_ChIP-Seq_MEL86_Mouse	1.01935742
48	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.00757087
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.99981113
50	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99698273
51	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.98548395
52	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97937365
53	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95189070
54	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.94840408
55	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.94840408
56	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.94710461
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94512924
58	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94344206
59	TP53_16413492_ChIP-PET_HCT116_Human	0.93898818
60	BCAT_22108803_ChIP-Seq_LS180_Human	0.93645146
61	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	0.93399844
62	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.93362521
63	STAT3_23295773_ChIP-Seq_U87_Human	0.92015805
64	TAF15_26573619_Chip-Seq_HEK293_Human	0.90755268
65	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.90503830
66	RUNX_20019798_ChIP-Seq_JUKART_Human	0.89656745
67	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.89526921
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.89166834
69	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.88754295
70	TCF4_23295773_ChIP-Seq_U87_Human	0.85393491
71	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.84806296
72	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	0.84713639
73	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83973804
74	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.83728066
75	AR_25329375_ChIP-Seq_VCAP_Human	0.81525851
76	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.78773756
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.78705818
78	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.78645603
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.78550996
80	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.78024333
81	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.77691340
82	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	0.77491764
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.77338003
84	SPI1_20517297_ChIP-Seq_HL60_Human	0.74752083
85	REST_21632747_ChIP-Seq_MESCs_Mouse	0.74701198
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.74291198
87	TAF2_19829295_ChIP-Seq_ESCs_Human	0.73461429
88	CEBPB_22108803_ChIP-Seq_LS180_Human	0.73072052
89	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.72439399
90	ER_23166858_ChIP-Seq_MCF-7_Human	0.72123005
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.71732817
92	NANOG_20526341_ChIP-Seq_ESCs_Human	0.71111819
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.71049247
94	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.70262782
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.69663939
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.69663939
97	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.69643087
98	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.69615399
99	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.69193138
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.69129052

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005464_abnormal_platelet_physiology	5.93363924
2	MP0004147_increased_porphyrin_level	3.36594765
3	MP0008004_abnormal_stomach_pH	3.03756398
4	MP0005083_abnormal_biliary_tract	3.01440636
5	MP0003656_abnormal_erythrocyte_physiolo	2.83403773
6	MP0005365_abnormal_bile_salt	2.82989232
7	MP0003724_increased_susceptibility_to	2.59494458
8	MP0008875_abnormal_xenobiotic_pharmacok	2.59095739
9	MP0005085_abnormal_gallbladder_physiolo	2.59002736
10	MP0004130_abnormal_muscle_cell	2.55852321
11	MP0003879_abnormal_hair_cell	2.54029796
12	MP0010329_abnormal_lipoprotein_level	2.46038740
13	MP0002139_abnormal_hepatobiliary_system	2.20773044
14	MP0003011_delayed_dark_adaptation	2.11349502
15	MP0005167_abnormal_blood-brain_barrier	2.10666183
16	MP0008775_abnormal_heart_ventricle	2.03575549
17	MP0003136_yellow_coat_color	1.93487226
18	MP0001968_abnormal_touch/_nociception	1.77409616
19	MP0003195_calcinosis	1.77106404
20	MP0002736_abnormal_nociception_after	1.72734614
21	MP0005360_urolithiasis	1.70758522
22	MP0000230_abnormal_systemic_arterial	1.70155021
23	MP0000465_gastrointestinal_hemorrhage	1.67946281
24	MP0004510_myositis	1.63918740
25	MP0003638_abnormal_response/metabolism_	1.61655791
26	MP0004084_abnormal_cardiac_muscle	1.60115990
27	MP0008872_abnormal_physiological_respon	1.58633634
28	MP0002118_abnormal_lipid_homeostasis	1.47624818
29	MP0005670_abnormal_white_adipose	1.40271616
30	MP0000343_altered_response_to	1.39660803
31	MP0002733_abnormal_thermal_nociception	1.38429835
32	MP0002876_abnormal_thyroid_physiology	1.38328195
33	MP0002653_abnormal_ependyma_morphology	1.37341783
34	MP0005646_abnormal_pituitary_gland	1.29866186
35	MP0009780_abnormal_chondrocyte_physiolo	1.27839281
36	MP0003252_abnormal_bile_duct	1.25605965
37	MP0002132_abnormal_respiratory_system	1.25237237
38	MP0005377_hearing/vestibular/ear_phenot	1.22018361
39	MP0003878_abnormal_ear_physiology	1.22018361
40	MP0005551_abnormal_eye_electrophysiolog	1.20522191
41	MP0001970_abnormal_pain_threshold	1.20509767
42	MP0004885_abnormal_endolymph	1.17840621
43	MP0004036_abnormal_muscle_relaxation	1.17359703
44	MP0003303_peritoneal_inflammation	1.16784593
45	MP0006276_abnormal_autonomic_nervous	1.16069095
46	MP0000249_abnormal_blood_vessel	1.15034938
47	MP0005535_abnormal_body_temperature	1.14600941
48	MP0009764_decreased_sensitivity_to	1.13078000
49	MP0004142_abnormal_muscle_tone	1.11516301
50	MP0001986_abnormal_taste_sensitivity	1.09909529
51	MP0005636_abnormal_mineral_homeostasis	1.08084191
52	MP0004859_abnormal_synaptic_plasticity	1.07682752
53	MP0001756_abnormal_urination	1.07299286
54	MP0005174_abnormal_tail_pigmentation	1.06333411
55	MP0003690_abnormal_glial_cell	1.05998066
56	MP0005084_abnormal_gallbladder_morpholo	1.05536733
57	MP0009745_abnormal_behavioral_response	1.04154177
58	MP0002638_abnormal_pupillary_reflex	1.02224371
59	MP0005332_abnormal_amino_acid	1.01024477
60	MP0004215_abnormal_myocardial_fiber	1.00023402
61	MP0001545_abnormal_hematopoietic_system	0.99733256
62	MP0005397_hematopoietic_system_phenotyp	0.99733256
63	MP0002064_seizures	0.98160810
64	MP0002272_abnormal_nervous_system	0.97748640
65	MP0008874_decreased_physiological_sensi	0.96902834
66	MP0001905_abnormal_dopamine_level	0.96737474
67	MP0003828_pulmonary_edema	0.95987099
68	MP0005448_abnormal_energy_balance	0.94636049
69	MP0005058_abnormal_lysosome_morphology	0.94377898
70	MP0001851_eye_inflammation	0.93189161
71	MP0009642_abnormal_blood_homeostasis	0.92354128
72	MP0001663_abnormal_digestive_system	0.89055946
73	MP0009763_increased_sensitivity_to	0.88842530
74	MP0010368_abnormal_lymphatic_system	0.88758048
75	MP0001486_abnormal_startle_reflex	0.87764913
76	MP0008569_lethality_at_weaning	0.86597813
77	MP0001765_abnormal_ion_homeostasis	0.86574693
78	MP0001664_abnormal_digestion	0.85405486
79	MP0005423_abnormal_somatic_nervous	0.84943668
80	MP0001666_abnormal_nutrient_absorption	0.83443538
81	MP0009643_abnormal_urine_homeostasis	0.81690402
82	MP0001879_abnormal_lymphatic_vessel	0.80085842
83	MP0002063_abnormal_learning/memory/cond	0.80027162
84	MP0002971_abnormal_brown_adipose	0.77983455
85	MP0003635_abnormal_synaptic_transmissio	0.77786377
86	MP0002735_abnormal_chemical_nociception	0.77728147
87	MP0001501_abnormal_sleep_pattern	0.77454482
88	MP0003632_abnormal_nervous_system	0.77420066
89	MP0003329_amyloid_beta_deposits	0.77253916
90	MP0005410_abnormal_fertilization	0.76850030
91	MP0004019_abnormal_vitamin_homeostasis	0.75947112
92	MP0003631_nervous_system_phenotype	0.75215829
93	MP0005171_absent_coat_pigmentation	0.75003228
94	MP0002067_abnormal_sensory_capabilities	0.74551401
95	MP0004484_altered_response_of	0.74503207
96	MP0003633_abnormal_nervous_system	0.73367470
97	MP0006138_congestive_heart_failure	0.72393969
98	MP0001485_abnormal_pinna_reflex	0.70487241
99	MP0000920_abnormal_myelination	0.69043513
100	MP0004085_abnormal_heartbeat	0.68946264

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Prolonged bleeding time (HP:0003010)	8.74766478
2	Menorrhagia (HP:0000132)	8.20086894
3	Increased mean platelet volume (HP:0011877)	7.55017662
4	Purpura (HP:0000979)	7.29079481
5	Abnormal platelet volume (HP:0011876)	7.07324879
6	Petechiae (HP:0000967)	6.68145741
7	Poikilocytosis (HP:0004447)	6.19091101
8	Epistaxis (HP:0000421)	5.96358288
9	Hyperlipoproteinemia (HP:0010980)	5.91462616
10	Gingival bleeding (HP:0000225)	5.82894720
11	Abnormality of the heme biosynthetic pathway (HP:0010472)	5.40679905
12	Acanthocytosis (HP:0001927)	4.79200954
13	Abnormal platelet function (HP:0011869)	4.38099622
14	Impaired platelet aggregation (HP:0003540)	4.38099622
15	Joint hemorrhage (HP:0005261)	3.95034898
16	Abnormality of the common coagulation pathway (HP:0010990)	3.48338936
17	Spontaneous hematomas (HP:0007420)	3.45628688
18	Xanthomatosis (HP:0000991)	3.44928188
19	Hypochromic microcytic anemia (HP:0004840)	3.27852588
20	Complement deficiency (HP:0004431)	3.21252374
21	Paralysis (HP:0003470)	3.03046466
22	Abnormal hemoglobin (HP:0011902)	2.90957880
23	Polycythemia (HP:0001901)	2.83457251
24	Abnormality of binocular vision (HP:0011514)	2.80323931
25	Diplopia (HP:0000651)	2.80323931
26	Spontaneous abortion (HP:0005268)	2.72518992
27	Bruising susceptibility (HP:0000978)	2.69058695
28	Systemic lupus erythematosus (HP:0002725)	2.67661210
29	Deep venous thrombosis (HP:0002625)	2.62814680
30	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.58470603
31	Prolonged partial thromboplastin time (HP:0003645)	2.50572021
32	Abnormal pupillary function (HP:0007686)	2.48115270
33	Decreased central vision (HP:0007663)	2.48086253
34	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.40537732
35	Conjunctival telangiectasia (HP:0000524)	2.38618931
36	Microcytic anemia (HP:0001935)	2.38119035
37	Polyphagia (HP:0002591)	2.36649584
38	Abnormality of iron homeostasis (HP:0011031)	2.34338453
39	Abnormality of complement system (HP:0005339)	2.33628529
40	Abnormality of transition element cation homeostasis (HP:0011030)	2.32189886
41	Ventricular fibrillation (HP:0001663)	2.31913811
42	Arthropathy (HP:0003040)	2.20241547
43	Glomerulonephritis (HP:0000099)	2.16391215
44	Hypochromic anemia (HP:0001931)	2.15255328
45	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.13552765
46	Thyroid-stimulating hormone excess (HP:0002925)	2.11565617
47	Joint swelling (HP:0001386)	2.10153743
48	Reticulocytosis (HP:0001923)	2.09659339
49	Dyschromatopsia (HP:0007641)	2.09585188
50	Febrile seizures (HP:0002373)	2.07780763
51	Abnormal ciliary motility (HP:0012262)	2.02609783
52	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98153627
53	Absent/shortened dynein arms (HP:0200106)	1.98153627
54	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.94707552
55	Abnormal respiratory motile cilium morphology (HP:0005938)	1.94069636
56	Abnormal respiratory epithelium morphology (HP:0012253)	1.94069636
57	Hypobetalipoproteinemia (HP:0003563)	1.88126524
58	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.87184903
59	Nausea (HP:0002018)	1.85175978
60	Hemorrhage of the eye (HP:0011885)	1.83939441
61	Generalized aminoaciduria (HP:0002909)	1.83324619
62	Congenital stationary night blindness (HP:0007642)	1.82773264
63	Ileus (HP:0002595)	1.81517865
64	Conjugated hyperbilirubinemia (HP:0002908)	1.81517004
65	Hyperventilation (HP:0002883)	1.81501636
66	Nephritis (HP:0000123)	1.81395320
67	Thrombophlebitis (HP:0004418)	1.79676661
68	Fair hair (HP:0002286)	1.79082470
69	Visual hallucinations (HP:0002367)	1.76605697
70	Pulmonary embolism (HP:0002204)	1.73436393
71	Cholelithiasis (HP:0001081)	1.72966997
72	Increased serum ferritin (HP:0003281)	1.72287421
73	Postural instability (HP:0002172)	1.71891192
74	Osteomalacia (HP:0002749)	1.71241679
75	Abnormal eating behavior (HP:0100738)	1.71208770
76	Hyperthyroidism (HP:0000836)	1.70616639
77	Tinnitus (HP:0000360)	1.69452606
78	Rickets (HP:0002748)	1.66430546
79	Vertigo (HP:0002321)	1.65311695
80	Hyperbilirubinemia (HP:0002904)	1.64315962
81	Cerebral palsy (HP:0100021)	1.62643793
82	Metabolic alkalosis (HP:0200114)	1.62174735
83	Hypophosphatemic rickets (HP:0004912)	1.61652052
84	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.59921441
85	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.59921441
86	Clumsiness (HP:0002312)	1.55083786
87	Blue irides (HP:0000635)	1.55036492
88	Hemiplegia (HP:0002301)	1.50817540
89	Polydipsia (HP:0001959)	1.50694106
90	Abnormal drinking behavior (HP:0030082)	1.50694106
91	Decreased circulating renin level (HP:0003351)	1.50332924
92	Abnormal gallbladder morphology (HP:0012437)	1.48456262
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.47284443
94	Muscle fiber splitting (HP:0003555)	1.46405920
95	Abnormality of lateral ventricle (HP:0030047)	1.45178312
96	Generalized hypopigmentation of hair (HP:0011358)	1.43376349
97	Progressive cerebellar ataxia (HP:0002073)	1.42605916
98	Gonadal dysgenesis (HP:0000133)	1.40780114
99	Atonic seizures (HP:0010819)	1.40609587
100	Hyperalaninemia (HP:0003348)	1.40592844

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	RIPK4	4.14413169
2	BMX	3.03225975
3	MYLK	2.73836993
4	TAOK3	2.35536584
5	PTK2B	2.28780091
6	DAPK2	2.14765123
7	ADRBK2	2.02597615
8	EIF2AK1	1.95506874
9	TEC	1.93140000
10	GRK5	1.93077109
11	WNK4	1.92872381
12	SYK	1.80969149
13	GRK6	1.68978437
14	NTRK3	1.66180654
15	MST4	1.65566255
16	BTK	1.60254828
17	BMPR1B	1.57998477
18	PIK3CG	1.50367701
19	ACVR1B	1.49873905
20	MAPKAPK3	1.39438458
21	GRK1	1.22771971
22	ZAP70	1.20854490
23	ERBB2	1.17176587
24	WNK1	1.16325732
25	SGK2	1.15984239
26	MAPK13	1.15504607
27	TNK2	1.13417041
28	PLK2	1.12162988
29	ADRBK1	1.10779884
30	CAMKK2	1.09721539
31	BMPR2	1.09336815
32	CSF1R	1.07688819
33	PINK1	1.06712833
34	FGR	1.05074899
35	SGK223	1.03016878
36	SGK494	1.03016878
37	MAPK15	1.00540292
38	PDK1	1.00092467
39	MAPK12	0.99777879
40	FES	0.99386387
41	TNIK	0.99187465
42	PIK3CA	0.98222787
43	TLK1	0.96474875
44	TXK	0.95142161
45	PDPK1	0.94708066
46	STK3	0.94114840
47	MAP2K3	0.93539429
48	RET	0.92693473
49	PKN1	0.90772733
50	HCK	0.90520943
51	MAP2K1	0.88299520
52	EPHA4	0.86824832
53	FRK	0.86812161
54	PAK3	0.85832810
55	EPHA3	0.85572609
56	PRKACG	0.84677393
57	CAMK1	0.83840133
58	NTRK2	0.80924107
59	MARK2	0.80863774
60	PNCK	0.80447757
61	PRKD1	0.79989727
62	MAP3K11	0.78505512
63	MAP4K2	0.73557781
64	JAK2	0.72514331
65	TYRO3	0.70591612
66	SGK3	0.70012907
67	ILK	0.69132561
68	INSRR	0.69002810
69	LYN	0.67809533
70	BLK	0.66531283
71	MINK1	0.64462323
72	DYRK1A	0.63460780
73	TRPM7	0.61444563
74	PRKAA2	0.60361029
75	PRKG1	0.59499199
76	PRKCQ	0.58492864
77	ITK	0.58441475
78	PDGFRB	0.58143453
79	MAP2K6	0.55861772
80	MAP3K2	0.54563650
81	DYRK1B	0.54151281
82	SGK1	0.53592836
83	AKT3	0.53276534
84	NLK	0.53026509
85	PRKCG	0.51577368
86	CSK	0.51523076
87	PHKG1	0.49626652
88	PHKG2	0.49626652
89	PRKACA	0.49515098
90	DAPK3	0.49310871
91	IKBKB	0.47881317
92	MUSK	0.47577578
93	CAMKK1	0.46799538
94	CAMK2A	0.46626657
95	FYN	0.46448822
96	PRKCA	0.45655655
97	IRAK1	0.45030190
98	OXSR1	0.43587457
99	TIE1	0.41851779
100	MAP2K4	0.41518204

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	2.64655670
2	Platelet activation_Homo sapiens_hsa04611	2.55419731
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.52908751
4	Complement and coagulation cascades_Homo sapiens_hsa04610	2.51301339
5	Caffeine metabolism_Homo sapiens_hsa00232	2.51117680
6	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.43732088
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.41089088
8	Histidine metabolism_Homo sapiens_hsa00340	2.21861995
9	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.15723427
10	Retinol metabolism_Homo sapiens_hsa00830	2.12117420
11	Arachidonic acid metabolism_Homo sapiens_hsa00590	2.04627378
12	Chemical carcinogenesis_Homo sapiens_hsa05204	1.97882733
13	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.88312570
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.87283838
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.77016999
16	Bile secretion_Homo sapiens_hsa04976	1.73423008
17	beta-Alanine metabolism_Homo sapiens_hsa00410	1.59134357
18	Fatty acid degradation_Homo sapiens_hsa00071	1.57756458
19	PPAR signaling pathway_Homo sapiens_hsa03320	1.55436532
20	Glycerolipid metabolism_Homo sapiens_hsa00561	1.49919442
21	Tyrosine metabolism_Homo sapiens_hsa00350	1.44506175
22	ABC transporters_Homo sapiens_hsa02010	1.43567240
23	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.38514827
24	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.37859213
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.35439573
26	Tryptophan metabolism_Homo sapiens_hsa00380	1.34084303
27	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.34025549
28	Fat digestion and absorption_Homo sapiens_hsa04975	1.31568628
29	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.28107182
30	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.27905180
31	Butanoate metabolism_Homo sapiens_hsa00650	1.24726838
32	Serotonergic synapse_Homo sapiens_hsa04726	1.22317660
33	ECM-receptor interaction_Homo sapiens_hsa04512	1.17811972
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.12759832
35	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.11350932
36	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.03311611
37	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.99225953
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98928106
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95960806
40	Morphine addiction_Homo sapiens_hsa05032	0.94874298
41	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.94135216
42	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.91663477
43	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.91506774
44	Circadian entrainment_Homo sapiens_hsa04713	0.91226502
45	Arginine and proline metabolism_Homo sapiens_hsa00330	0.90131259
46	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.88779532
47	GABAergic synapse_Homo sapiens_hsa04727	0.87451541
48	Arginine biosynthesis_Homo sapiens_hsa00220	0.86765987
49	Peroxisome_Homo sapiens_hsa04146	0.83810270
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.80606164
51	Pancreatic secretion_Homo sapiens_hsa04972	0.78042327
52	Malaria_Homo sapiens_hsa05144	0.77644309
53	Olfactory transduction_Homo sapiens_hsa04740	0.75858017
54	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73789498
55	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.71152939
56	Glutamatergic synapse_Homo sapiens_hsa04724	0.70211994
57	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.69289319
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.68255133
59	Phototransduction_Homo sapiens_hsa04744	0.66021108
60	Gap junction_Homo sapiens_hsa04540	0.64958261
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.64544739
62	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.64339325
63	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.63594377
64	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.63512864
65	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.62267644
66	Chemokine signaling pathway_Homo sapiens_hsa04062	0.61590329
67	Gastric acid secretion_Homo sapiens_hsa04971	0.61501182
68	Calcium signaling pathway_Homo sapiens_hsa04020	0.58236010
69	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57564659
70	Renin secretion_Homo sapiens_hsa04924	0.54665919
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.53611287
72	Long-term depression_Homo sapiens_hsa04730	0.52951443
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52308172
74	Nicotine addiction_Homo sapiens_hsa05033	0.51923972
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.51029713
76	Mineral absorption_Homo sapiens_hsa04978	0.49841093
77	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.49790037
78	Salivary secretion_Homo sapiens_hsa04970	0.49251453
79	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.48633342
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.47714736
81	Choline metabolism in cancer_Homo sapiens_hsa05231	0.47311721
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.47270095
83	Fatty acid elongation_Homo sapiens_hsa00062	0.45209997
84	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.44511972
85	Amphetamine addiction_Homo sapiens_hsa05031	0.43181614
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.42523383
87	Sulfur relay system_Homo sapiens_hsa04122	0.41317547
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.40326573
89	Cholinergic synapse_Homo sapiens_hsa04725	0.39762041
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.38737636
91	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.38371807
92	Sulfur metabolism_Homo sapiens_hsa00920	0.37421253
93	Endocytosis_Homo sapiens_hsa04144	0.36275819
94	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.36189305
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.33820394
96	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.32953669
97	Insulin secretion_Homo sapiens_hsa04911	0.32775019
98	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.32327646
99	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.32063835
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.31760371

FAXDC2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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