FBF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.83336217
2dendritic spine morphogenesis (GO:0060997)4.66689540
3chromosome condensation (GO:0030261)4.66577577
4synaptic vesicle maturation (GO:0016188)4.53564893
5semaphorin-plexin signaling pathway (GO:0071526)4.42402456
6locomotory exploration behavior (GO:0035641)4.38401154
7motile cilium assembly (GO:0044458)4.38226860
8negative regulation of erythrocyte differentiation (GO:0045647)4.32448782
9DNA packaging (GO:0006323)4.17190308
10mannose metabolic process (GO:0006013)4.11095804
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.06222358
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.98686545
13establishment of nucleus localization (GO:0040023)3.84252392
14proline metabolic process (GO:0006560)3.83242749
15regulation of mammary gland epithelial cell proliferation (GO:0033599)3.71961273
16cytoskeletal anchoring at plasma membrane (GO:0007016)3.69516807
17proline biosynthetic process (GO:0006561)3.68976644
18nucleosome disassembly (GO:0006337)3.66913026
19protein-DNA complex disassembly (GO:0032986)3.66913026
20sperm capacitation (GO:0048240)3.59656502
21intracellular estrogen receptor signaling pathway (GO:0030520)3.59542194
22mitotic G1 DNA damage checkpoint (GO:0031571)3.59458483
23positive regulation of synapse maturation (GO:0090129)3.58725087
24histone H4 deacetylation (GO:0070933)3.55200984
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.53873741
26sodium ion export (GO:0071436)3.50297544
27microtubule severing (GO:0051013)3.50217963
28axonemal dynein complex assembly (GO:0070286)3.48495373
29establishment of apical/basal cell polarity (GO:0035089)3.41557363
30histone H3-K9 demethylation (GO:0033169)3.38895006
31apoptotic process involved in morphogenesis (GO:0060561)3.38639956
32outflow tract septum morphogenesis (GO:0003148)3.37636507
33dendritic spine organization (GO:0097061)3.35914442
34mitotic G1/S transition checkpoint (GO:0044819)3.34995904
35snRNA metabolic process (GO:0016073)3.32950930
36spliceosomal tri-snRNP complex assembly (GO:0000244)3.32787253
37regulation of female receptivity (GO:0045924)3.31985482
38regulation of synapse structural plasticity (GO:0051823)3.31487744
39peptidyl-lysine dimethylation (GO:0018027)3.29534811
40positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.28881538
41regulation of chromatin binding (GO:0035561)3.24744135
42G1 DNA damage checkpoint (GO:0044783)3.21827655
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.18815495
44vocalization behavior (GO:0071625)3.18776437
45regulation of histone H3-K27 methylation (GO:0061085)3.18546245
46negative regulation of DNA-templated transcription, elongation (GO:0032785)3.17826718
47GDP-mannose metabolic process (GO:0019673)3.15232384
48cell communication by electrical coupling (GO:0010644)3.15201583
49histone H3 deacetylation (GO:0070932)3.10275511
50exploration behavior (GO:0035640)3.08369298
51RNA localization (GO:0006403)3.08047231
52positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.06495005
53lymph vessel development (GO:0001945)3.05009253
54dendrite morphogenesis (GO:0048813)3.03450048
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02021108
56glial cell proliferation (GO:0014009)3.01814948
57phosphatidylethanolamine biosynthetic process (GO:0006646)2.98183160
58snRNA processing (GO:0016180)2.97736052
59cerebellar Purkinje cell layer development (GO:0021680)2.97322831
60activation of protein kinase A activity (GO:0034199)2.95036942
61mitotic chromosome condensation (GO:0007076)2.94800297
62negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.92529679
63glutamate secretion (GO:0014047)2.90056940
64tooth mineralization (GO:0034505)2.89581890
65chromatin silencing (GO:0006342)2.87994373
66regulation of glutamate receptor signaling pathway (GO:1900449)2.87524249
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87136687
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86322955
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86211456
70positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.84692879
71retinoic acid receptor signaling pathway (GO:0048384)2.84074959
72dosage compensation (GO:0007549)2.83498385
73nuclear pore complex assembly (GO:0051292)2.82979757
74membrane protein intracellular domain proteolysis (GO:0031293)2.82513617
75Golgi transport vesicle coating (GO:0048200)2.82509008
76COPI coating of Golgi vesicle (GO:0048205)2.82509008
77positive regulation of histone deacetylation (GO:0031065)2.81746781
78planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81667801
79cochlea morphogenesis (GO:0090103)2.80672514
80neuromuscular process controlling balance (GO:0050885)2.80354854
81regulation of nucleobase-containing compound transport (GO:0032239)2.79452465
82sperm motility (GO:0030317)2.79363011
83peptidyl-arginine omega-N-methylation (GO:0035247)2.79031380
844-hydroxyproline metabolic process (GO:0019471)2.78055122
85regulation of neuronal synaptic plasticity (GO:0048168)2.77940708
86DNA conformation change (GO:0071103)2.76072159
87cell migration in hindbrain (GO:0021535)2.73898897
88adherens junction assembly (GO:0034333)2.73229895
89protein retention in ER lumen (GO:0006621)2.73128964
90innervation (GO:0060384)2.72733495
91maternal placenta development (GO:0001893)2.72562130
92regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.72170236
93regulation of NFAT protein import into nucleus (GO:0051532)2.72149137
94cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.72017820
95female mating behavior (GO:0060180)2.71273448
96activation of Rac GTPase activity (GO:0032863)2.70555629
97regulation of ARF protein signal transduction (GO:0032012)2.70397283
98mammary gland epithelial cell differentiation (GO:0060644)2.70047653
99axonal fasciculation (GO:0007413)2.69736487
100negative regulation of granulocyte differentiation (GO:0030853)2.67552239
101cellular potassium ion homeostasis (GO:0030007)2.66198497
102plasma membrane repair (GO:0001778)2.66189905
103regulation of interleukin-13 production (GO:0032656)2.66077083
104microtubule depolymerization (GO:0007019)2.65446647
105neurotransmitter secretion (GO:0007269)2.64846127
106cell-cell junction maintenance (GO:0045217)2.64048375
107histone lysine demethylation (GO:0070076)2.63738026
108axon extension involved in axon guidance (GO:0048846)2.63162040
109neuron projection extension involved in neuron projection guidance (GO:1902284)2.63162040
110regulation of long-term neuronal synaptic plasticity (GO:0048169)2.62740922
111convergent extension (GO:0060026)2.62226189
112synaptic vesicle exocytosis (GO:0016079)2.61752213
113phosphatidylethanolamine metabolic process (GO:0046337)2.60546403
114cilium or flagellum-dependent cell motility (GO:0001539)2.60278982
115atrioventricular valve morphogenesis (GO:0003181)2.59852157
116activation of JUN kinase activity (GO:0007257)2.59747145
117negative regulation of cytosolic calcium ion concentration (GO:0051481)2.59622506
118hippo signaling (GO:0035329)2.59595235
119neurotransmitter-gated ion channel clustering (GO:0072578)2.58957648
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.58886243
121positive regulation of protein deacetylation (GO:0090312)2.58376753
122DNA unwinding involved in DNA replication (GO:0006268)2.58309505
123regulation of Rab GTPase activity (GO:0032313)2.57458875
124positive regulation of Rab GTPase activity (GO:0032851)2.57458875
125DNA replication initiation (GO:0006270)2.56542814
126regulation of synaptic vesicle exocytosis (GO:2000300)2.56253201
127protein localization to synapse (GO:0035418)2.56144690
128coronary vasculature morphogenesis (GO:0060977)2.55451787
129regulation of T-helper 2 cell differentiation (GO:0045628)2.55255468
130neuronal ion channel clustering (GO:0045161)2.54677017
131clathrin coat assembly (GO:0048268)2.54086831
132regulation of interleukin-5 production (GO:0032674)2.53565265
133prepulse inhibition (GO:0060134)2.53317012
134insulin-like growth factor receptor signaling pathway (GO:0048009)2.52794114
135amyloid precursor protein catabolic process (GO:0042987)2.51816480
136regulation of dendritic spine morphogenesis (GO:0061001)2.50909278
137embryonic camera-type eye development (GO:0031076)2.50654539
138regulation of RNA export from nucleus (GO:0046831)2.49355883
139histone demethylation (GO:0016577)2.48659344
140negative regulation of myotube differentiation (GO:0010832)2.48077702
141thymic T cell selection (GO:0045061)2.47230449
142endothelial cell chemotaxis (GO:0035767)2.46561405
143negative regulation of cell size (GO:0045792)2.46139185
144desmosome organization (GO:0002934)2.46013544
145lung epithelium development (GO:0060428)2.45586057
146negative regulation of catenin import into nucleus (GO:0035414)2.42580942
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.42002802
148cell-substrate adherens junction assembly (GO:0007045)2.41208038
149focal adhesion assembly (GO:0048041)2.41208038
150embryonic foregut morphogenesis (GO:0048617)2.40044530
151nucleus localization (GO:0051647)2.39646365
152negative regulation of organelle assembly (GO:1902116)2.39082337
153neuron recognition (GO:0008038)2.36687467
154cerebellar Purkinje cell differentiation (GO:0021702)2.36229993
155positive regulation of dendritic spine morphogenesis (GO:0061003)2.36018809
156regulation of synapse maturation (GO:0090128)2.34641979
157central nervous system projection neuron axonogenesis (GO:0021952)2.33673631
158membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.33377561
159positive regulation of dendrite morphogenesis (GO:0050775)2.32565633
160dorsal/ventral axis specification (GO:0009950)2.32419854
161collecting duct development (GO:0072044)2.31685608
162auditory behavior (GO:0031223)2.31281055
163regulation of ARF GTPase activity (GO:0032312)2.30308237
164signal complex assembly (GO:0007172)2.30178374
165regulation of clathrin-mediated endocytosis (GO:2000369)2.29566667
166cell communication involved in cardiac conduction (GO:0086065)2.28829590
167cerebral cortex neuron differentiation (GO:0021895)2.26736473
168stress granule assembly (GO:0034063)2.26503376
169positive regulation of dendrite development (GO:1900006)2.26283512
170axon extension (GO:0048675)2.25561156
171proline transport (GO:0015824)2.24646791
172membrane depolarization during action potential (GO:0086010)2.23957071
173gamma-aminobutyric acid transport (GO:0015812)2.23521947
174pre-miRNA processing (GO:0031054)2.22235661
175regulation of fatty acid beta-oxidation (GO:0031998)2.21344559
176cellular sodium ion homeostasis (GO:0006883)2.21253144
177G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.21216199
178camera-type eye morphogenesis (GO:0048593)2.20884078
179protein targeting to plasma membrane (GO:0072661)2.20540648
180vesicle transport along microtubule (GO:0047496)2.19876350
181rRNA catabolic process (GO:0016075)2.19875987
182negative regulation of sodium ion transport (GO:0010766)2.17244518
183stress fiber assembly (GO:0043149)2.17010672
184neuromuscular junction development (GO:0007528)2.15755235
185ionotropic glutamate receptor signaling pathway (GO:0035235)2.15701368
186synapse organization (GO:0050808)2.15518388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.74213270
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.09236746
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.05401763
4VDR_21846776_ChIP-Seq_THP-1_Human2.81476272
5STAT6_21828071_ChIP-Seq_BEAS2B_Human2.69036533
6TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.53571626
7ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41499286
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.31800341
9DROSHA_22980978_ChIP-Seq_HELA_Human2.25440745
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24590869
11KDM2B_26808549_Chip-Seq_K562_Human2.21022721
12P68_20966046_ChIP-Seq_HELA_Human2.17985321
13E2F7_22180533_ChIP-Seq_HELA_Human2.15936255
14WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.06090396
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02586623
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02586623
17* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.98625565
18KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96573872
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.93270989
20* TET1_21451524_ChIP-Seq_MESCs_Mouse1.89123312
21DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.88995356
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.88754709
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.87548134
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.87398486
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.82124941
26* SA1_27219007_Chip-Seq_ERYTHROID_Human1.81947196
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.79387601
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.78512040
29KDM2B_26808549_Chip-Seq_DND41_Human1.77906728
30MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77115048
31SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74891373
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.74885125
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74784987
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74693267
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.74422726
36JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73846509
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73764052
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72777709
39CTCF_27219007_Chip-Seq_ERYTHROID_Human1.71881876
40LXR_22292898_ChIP-Seq_THP-1_Human1.71067551
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.69837206
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.68563324
43FOXM1_23109430_ChIP-Seq_U2OS_Human1.64272468
44BCOR_27268052_Chip-Seq_Bcells_Human1.63300627
45SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.63298085
46KDM2B_26808549_Chip-Seq_JURKAT_Human1.62186438
47EZH2_27304074_Chip-Seq_ESCs_Mouse1.59270311
48MAF_26560356_Chip-Seq_TH2_Human1.58515932
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57991468
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.57205780
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.55108195
52SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.54951679
53REST_21632747_ChIP-Seq_MESCs_Mouse1.53447744
54BCL6_27268052_Chip-Seq_Bcells_Human1.52268722
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.52107888
56SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.50506314
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50145838
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.49311628
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.48543044
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.47968851
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47617472
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46695390
63MAF_26560356_Chip-Seq_TH1_Human1.46296616
64* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.45113516
65TP53_22127205_ChIP-Seq_IMR90_Human1.44279719
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.42399000
67KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41294008
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41268664
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39959983
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39109505
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.38580249
72PHF8_20622854_ChIP-Seq_HELA_Human1.38227541
73* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.38218552
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.37057584
75UTX_26944678_Chip-Seq_JUKART_Human1.34865517
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34476425
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.34253535
78NCOR1_26117541_ChIP-Seq_K562_Human1.34193413
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33698320
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.33677258
81MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.33585944
82CREB1_26743006_Chip-Seq_LNCaP_Human1.32841117
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32080852
84TCF7_22412390_ChIP-Seq_EML_Mouse1.31928988
85SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31860058
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.30964255
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.30929007
88TP63_22573176_ChIP-Seq_HFKS_Human1.30195416
89MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.28157851
90CLOCK_20551151_ChIP-Seq_293T_Human1.27877161
91ZNF263_19887448_ChIP-Seq_K562_Human1.26759925
92IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25019316
93E2F1_20622854_ChIP-Seq_HELA_Human1.24430469
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24321001
95CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22625594
96CTCF_21964334_Chip-Seq_Bcells_Human1.22144472
97VDR_24763502_ChIP-Seq_THP-1_Human1.21479217
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21426922
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.20367805
100* RARA_24833708_ChIP-Seq_LIVER_Mouse1.20298644
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.19046129
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18714523
103ZNF217_24962896_ChIP-Seq_MCF-7_Human1.17958360
104ZNF274_21170338_ChIP-Seq_K562_Hela1.16969344
105* FOXP1_21924763_ChIP-Seq_HESCs_Human1.16794933
106SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16349893
107CTCF_26484167_Chip-Seq_Bcells_Mouse1.16118819
108DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15209019
109OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14795347
110AHR_22903824_ChIP-Seq_MCF-7_Human1.14405679
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13796173
112* RARB_24833708_ChIP-Seq_LIVER_Mouse1.13682079
113ATF3_27146783_Chip-Seq_COLON_Human1.13644141
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.13382053
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.12882096
116ESR1_15608294_ChIP-ChIP_MCF-7_Human1.12579176
117GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.12489332
118CTCF_27219007_Chip-Seq_Bcells_Human1.12256643
119CTCF_21964334_ChIP-Seq_BJAB-B_Human1.11767295
120ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.11344301
121SA1_27219007_Chip-Seq_Bcells_Human1.10781157
122ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09752757
123RACK7_27058665_Chip-Seq_MCF-7_Human1.09377840
124GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09191870
125RUNX1_27514584_Chip-Seq_MCF-7_Human1.09144090
126PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08833989
127AR_19668381_ChIP-Seq_PC3_Human1.07700884
128CTCF_20526341_ChIP-Seq_ESCs_Human1.07656253
129* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07457503
130PU.1_20513432_ChIP-Seq_Bcells_Mouse1.07075069
131RUNX1_22412390_ChIP-Seq_EML_Mouse1.07002022
132NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06745398
133RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06073536
134* SMC4_20622854_ChIP-Seq_HELA_Human1.06001675
135YY1_22570637_ChIP-Seq_MALME-3M_Human1.05115950
136ARNT_22903824_ChIP-Seq_MCF-7_Human1.04521291
137TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03968067
138XRN2_22483619_ChIP-Seq_HELA_Human1.03771563
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03159225
140THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03128338
141PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.02987918
142SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02691811
143TP53_20018659_ChIP-ChIP_R1E_Mouse1.02615332
144* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.02166673
145ELK3_25401928_ChIP-Seq_HUVEC_Human1.02098743
146ETS1_21867929_ChIP-Seq_TH2_Mouse1.01547364
147EGR1_19374776_ChIP-ChIP_THP-1_Human1.00835428
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99870542
149CTNNB1_20460455_ChIP-Seq_HCT116_Human0.97329597
150TET1_21490601_ChIP-Seq_MESCs_Mouse0.96967759
151RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95355697
152MYC_22102868_ChIP-Seq_BL_Human0.95294972
153EP300_21415370_ChIP-Seq_HL-1_Mouse0.94637563
154FOXA2_19822575_ChIP-Seq_HepG2_Human0.93897698
155YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93561784
156PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93517560
157SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93310373
158FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93071833
159* TP53_23651856_ChIP-Seq_MEFs_Mouse0.92389088
160PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.91538519
161SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89590702

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.95488341
2MP0000678_abnormal_parathyroid_gland3.42406507
3MP0005058_abnormal_lysosome_morphology2.84306902
4MP0003705_abnormal_hypodermis_morpholog2.74443965
5MP0009780_abnormal_chondrocyte_physiolo2.63388074
6MP0003635_abnormal_synaptic_transmissio2.56128176
7MP0003283_abnormal_digestive_organ2.53600484
8MP0000569_abnormal_digit_pigmentation2.43521155
9MP0005451_abnormal_body_composition2.42003740
10MP0010234_abnormal_vibrissa_follicle2.40208605
11MP0008260_abnormal_autophagy2.25349110
12MP0001348_abnormal_lacrimal_gland2.22474454
13MP0005623_abnormal_meninges_morphology2.20339464
14MP0000537_abnormal_urethra_morphology2.19767685
15MP0003172_abnormal_lysosome_physiology2.10111408
16MP0010030_abnormal_orbit_morphology2.04095124
17MP0004185_abnormal_adipocyte_glucose2.03311647
18MP0002653_abnormal_ependyma_morphology1.99411464
19MP0002063_abnormal_learning/memory/cond1.99095321
20MP0004858_abnormal_nervous_system1.98114283
21MP0000778_abnormal_nervous_system1.96302790
22MP0002909_abnormal_adrenal_gland1.95212803
23MP0008961_abnormal_basal_metabolism1.95004306
24MP0000681_abnormal_thyroid_gland1.94734357
25MP0002234_abnormal_pharynx_morphology1.87679909
26MP0001346_abnormal_lacrimal_gland1.85719419
27MP0005083_abnormal_biliary_tract1.85705537
28MP0001873_stomach_inflammation1.84520971
29MP0005076_abnormal_cell_differentiation1.78635877
30MP0000534_abnormal_ureter_morphology1.78512909
31MP0004270_analgesia1.74009827
32MP0003453_abnormal_keratinocyte_physiol1.73214969
33MP0005666_abnormal_adipose_tissue1.72491938
34MP0002796_impaired_skin_barrier1.69981221
35MP0004233_abnormal_muscle_weight1.69787343
36MP0002877_abnormal_melanocyte_morpholog1.69715927
37MP0005377_hearing/vestibular/ear_phenot1.64575764
38MP0003878_abnormal_ear_physiology1.64575764
39MP0004811_abnormal_neuron_physiology1.62360146
40MP0003111_abnormal_nucleus_morphology1.60925264
41MP0005409_darkened_coat_color1.57214770
42MP0003115_abnormal_respiratory_system1.51514219
43MP0005501_abnormal_skin_physiology1.50975156
44MP0000858_altered_metastatic_potential1.49651411
45MP0003122_maternal_imprinting1.46959505
46MP0005670_abnormal_white_adipose1.46942679
47MP0000955_abnormal_spinal_cord1.45532920
48MP0009053_abnormal_anal_canal1.44339875
49MP0003693_abnormal_embryo_hatching1.44206637
50MP0005410_abnormal_fertilization1.42817539
51MP0009745_abnormal_behavioral_response1.41629012
52MP0003077_abnormal_cell_cycle1.37844005
53MP0004947_skin_inflammation1.37347975
54MP0002064_seizures1.35429094
55MP0000751_myopathy1.35257095
56MP0004885_abnormal_endolymph1.33962252
57MP0003763_abnormal_thymus_physiology1.33690535
58MP0003861_abnormal_nervous_system1.33052065
59MP0002132_abnormal_respiratory_system1.32707694
60MP0003942_abnormal_urinary_system1.30643299
61MP0001849_ear_inflammation1.29391877
62MP0002184_abnormal_innervation1.28058028
63MP0000428_abnormal_craniofacial_morphol1.26905990
64MP0003329_amyloid_beta_deposits1.25773371
65MP0002152_abnormal_brain_morphology1.25563554
66MP0009046_muscle_twitch1.25516252
67MP0008007_abnormal_cellular_replicative1.25486875
68MP0003436_decreased_susceptibility_to1.24791969
69MP0002089_abnormal_postnatal_growth/wei1.24381774
70MP0005187_abnormal_penis_morphology1.23999811
71MP0002557_abnormal_social/conspecific_i1.21658273
72MP0002572_abnormal_emotion/affect_behav1.20594797
73MP0005499_abnormal_olfactory_system1.16860208
74MP0005394_taste/olfaction_phenotype1.16860208
75MP0009333_abnormal_splenocyte_physiolog1.16010146
76MP0001299_abnormal_eye_distance/1.14626574
77MP0002822_catalepsy1.14362094
78MP0008569_lethality_at_weaning1.13945286
79MP0001486_abnormal_startle_reflex1.13380990
80MP0002932_abnormal_joint_morphology1.09916928
81MP0003566_abnormal_cell_adhesion1.08102996
82MP0001730_embryonic_growth_arrest1.07253481
83MP0000566_synostosis1.06767674
84MP0000703_abnormal_thymus_morphology1.04819426
85MP0005248_abnormal_Harderian_gland1.04145650
86MP0003698_abnormal_male_reproductive1.04067692
87MP0002882_abnormal_neuron_morphology1.03746635
88MP0005423_abnormal_somatic_nervous1.03528557
89MP0003119_abnormal_digestive_system1.03394959
90MP0004808_abnormal_hematopoietic_stem1.02413319
91MP0001984_abnormal_olfaction1.00824742
92MP0003091_abnormal_cell_migration1.00695487
93MP0003880_abnormal_central_pattern1.00415257
94MP0000013_abnormal_adipose_tissue0.99346213
95MP0002734_abnormal_mechanical_nocicepti0.97577176
96MP0001968_abnormal_touch/_nociception0.97192860
97MP0000003_abnormal_adipose_tissue0.97084477
98MP0002282_abnormal_trachea_morphology0.97046988
99MP0004272_abnormal_basement_membrane0.96686908
100MP0003385_abnormal_body_wall0.96546656
101MP0000467_abnormal_esophagus_morphology0.95988041
102MP0000733_abnormal_muscle_development0.95607021
103MP0002396_abnormal_hematopoietic_system0.93822056
104MP0002060_abnormal_skin_morphology0.93528194
105MP0005621_abnormal_cell_physiology0.93172366
106MP0000350_abnormal_cell_proliferation0.92898964
107MP0003300_gastrointestinal_ulcer0.91734316
108MP0002272_abnormal_nervous_system0.91583792
109MP0002896_abnormal_bone_mineralization0.91323399
110MP0002080_prenatal_lethality0.91254891
111MP0003787_abnormal_imprinting0.91172233
112MP0001270_distended_abdomen0.91101547
113MP0003279_aneurysm0.90910280
114MP0001177_atelectasis0.90830546
115MP0003935_abnormal_craniofacial_develop0.90221697
116MP0001216_abnormal_epidermal_layer0.88474051
117MP0000313_abnormal_cell_death0.88444562
118MP0010630_abnormal_cardiac_muscle0.87081822
119MP0010352_gastrointestinal_tract_polyps0.86879839
120MP0005167_abnormal_blood-brain_barrier0.85918685
121MP0001501_abnormal_sleep_pattern0.85679883
122MP0009278_abnormal_bone_marrow0.85265565
123MP0010307_abnormal_tumor_latency0.85058678
124MP0002249_abnormal_larynx_morphology0.84386339
125MP0002085_abnormal_embryonic_tissue0.83642964
126MP0002697_abnormal_eye_size0.83592649
127MP0001929_abnormal_gametogenesis0.83344675
128MP0009931_abnormal_skin_appearance0.82767351
129MP0006072_abnormal_retinal_apoptosis0.82312365
130MP0005375_adipose_tissue_phenotype0.81911624
131MP0003879_abnormal_hair_cell0.81511015
132MP0005380_embryogenesis_phenotype0.81448236
133MP0001672_abnormal_embryogenesis/_devel0.81448236
134MP0003123_paternal_imprinting0.80794820
135MP0002116_abnormal_craniofacial_bone0.80052170
136MP0002081_perinatal_lethality0.78147606
137MP0002970_abnormal_white_adipose0.77800322
138MP0004130_abnormal_muscle_cell0.77564599
139MP0002733_abnormal_thermal_nociception0.77404290
140MP0002084_abnormal_developmental_patter0.77032510
141MP0008770_decreased_survivor_rate0.76703564
142MP0002161_abnormal_fertility/fecundity0.76186280
143MP0000747_muscle_weakness0.75896440
144MP0008932_abnormal_embryonic_tissue0.75514359
145MP0010094_abnormal_chromosome_stability0.74757664
146MP0003634_abnormal_glial_cell0.74654044
147MP0004957_abnormal_blastocyst_morpholog0.74617853
148MP0004381_abnormal_hair_follicle0.74558116
149MP0002067_abnormal_sensory_capabilities0.74456104
150MP0005386_behavior/neurological_phenoty0.74326528
151MP0004924_abnormal_behavior0.74326528
152MP0002269_muscular_atrophy0.73711104
153MP0000631_abnormal_neuroendocrine_gland0.73579335
154MP0000490_abnormal_crypts_of0.73446532
155MP0002233_abnormal_nose_morphology0.73318339
156MP0008789_abnormal_olfactory_epithelium0.72974139
157MP0001340_abnormal_eyelid_morphology0.72857321
158MP0002066_abnormal_motor_capabilities/c0.72691364
159MP0004087_abnormal_muscle_fiber0.72136497
160MP0006138_congestive_heart_failure0.70603892
161MP0000759_abnormal_skeletal_muscle0.70300060
162MP0003984_embryonic_growth_retardation0.67257484
163MP0003303_peritoneal_inflammation0.67035587
164MP0000579_abnormal_nail_morphology0.64283522
165MP0000477_abnormal_intestine_morphology0.63146762
166MP0001958_emphysema0.62559676
167MP0000049_abnormal_middle_ear0.62267685
168MP0005023_abnormal_wound_healing0.62153466
169MP0002925_abnormal_cardiovascular_devel0.61551335

Predicted human phenotypes

RankGene SetZ-score
1Broad face (HP:0000283)4.12405820
2Nasal polyposis (HP:0100582)3.82870475
3Hyperacusis (HP:0010780)3.51324615
4Stridor (HP:0010307)3.46184830
5Ulnar bowing (HP:0003031)3.45904883
6Abnormality of the lower motor neuron (HP:0002366)3.38873466
7Obstructive sleep apnea (HP:0002870)3.31993135
8Male infertility (HP:0003251)3.26423050
9Broad distal phalanx of finger (HP:0009836)3.25307644
10Abnormality of the nasal mucosa (HP:0000433)3.20875798
11Atelectasis (HP:0100750)3.14554760
12Bell-shaped thorax (HP:0001591)3.11135639
13Insomnia (HP:0100785)3.07721655
14Elfin facies (HP:0004428)3.06487858
15Cerebral aneurysm (HP:0004944)3.03400706
16Megalencephaly (HP:0001355)3.00695020
17Shallow orbits (HP:0000586)2.99359436
18Myokymia (HP:0002411)2.96161301
19Abnormality of the aortic arch (HP:0012303)2.94463374
20Renovascular hypertension (HP:0100817)2.93470420
21Renal duplication (HP:0000075)2.73102743
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71683625
23Pointed chin (HP:0000307)2.65367428
24Turricephaly (HP:0000262)2.62902801
25Thin bony cortex (HP:0002753)2.60613216
26Short 4th metacarpal (HP:0010044)2.58995028
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.58995028
28Drooling (HP:0002307)2.55472277
29Excessive salivation (HP:0003781)2.55472277
30Overriding aorta (HP:0002623)2.50587887
31Distal lower limb amyotrophy (HP:0008944)2.48570769
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48194894
33Abnormality of the fingertips (HP:0001211)2.42895080
34Truncus arteriosus (HP:0001660)2.40451198
35Upper limb amyotrophy (HP:0009129)2.39402162
36Distal upper limb amyotrophy (HP:0007149)2.39402162
37Macroorchidism (HP:0000053)2.35933740
38Neoplasm of the heart (HP:0100544)2.29471573
39Focal seizures (HP:0007359)2.28342497
40Heterotopia (HP:0002282)2.26169881
41Lymphangioma (HP:0100764)2.24788677
42Bowel incontinence (HP:0002607)2.24646813
43Hyperthyroidism (HP:0000836)2.24066582
44Dynein arm defect of respiratory motile cilia (HP:0012255)2.22293375
45Absent/shortened dynein arms (HP:0200106)2.22293375
46Cervical subluxation (HP:0003308)2.22084156
47Abnormality of the 4th metacarpal (HP:0010012)2.20674967
48Aplasia/Hypoplasia of the sacrum (HP:0008517)2.20666135
49Flat cornea (HP:0007720)2.19801366
50Obsessive-compulsive behavior (HP:0000722)2.19243298
51Bowel diverticulosis (HP:0005222)2.18499180
52Flattened epiphyses (HP:0003071)2.17800265
53Colitis (HP:0002583)2.16515208
54Abnormality of the diencephalon (HP:0010662)2.16180444
55Ankyloglossia (HP:0010296)2.15534666
56Visual hallucinations (HP:0002367)2.13917683
57Abnormality of the distal phalanx of the thumb (HP:0009617)2.12954598
58Germ cell neoplasia (HP:0100728)2.11446930
59Ankle clonus (HP:0011448)2.11072024
60Broad metatarsal (HP:0001783)2.10068828
61Bladder diverticulum (HP:0000015)2.09564690
62Hypoparathyroidism (HP:0000829)2.09288449
63Hand muscle atrophy (HP:0009130)2.08609703
64Short nail (HP:0001799)2.08510984
65Abnormal large intestine physiology (HP:0012700)2.05545592
66Aneurysm (HP:0002617)2.03710316
67Hemiplegia (HP:0002301)2.03387105
68Aortic aneurysm (HP:0004942)2.02707592
69Agitation (HP:0000713)2.02152530
70Abnormal respiratory motile cilium physiology (HP:0012261)2.02073512
71Protrusio acetabuli (HP:0003179)2.01731226
72Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00873602
73Action tremor (HP:0002345)1.99441036
74Flat acetabular roof (HP:0003180)1.99030702
75Abnormality of the astrocytes (HP:0100707)1.98477939
76Astrocytoma (HP:0009592)1.98477939
77Annular pancreas (HP:0001734)1.98398082
78Mitral valve prolapse (HP:0001634)1.96972588
79Impaired vibration sensation in the lower limbs (HP:0002166)1.96681513
80Enlarged penis (HP:0000040)1.95895438
81Nuclear cataract (HP:0100018)1.95758135
82Seborrheic dermatitis (HP:0001051)1.95492122
83Mitral regurgitation (HP:0001653)1.94447118
84Arterial tortuosity (HP:0005116)1.94060646
85Lower limb amyotrophy (HP:0007210)1.93393261
86Abnormality of the distal phalanges of the toes (HP:0010182)1.92770987
87Deviation of the hallux (HP:0010051)1.92295020
88Long toe (HP:0010511)1.91685999
89Increased connective tissue (HP:0009025)1.91476044
90Bronchomalacia (HP:0002780)1.89919824
91Hallux valgus (HP:0001822)1.89853235
92Growth hormone excess (HP:0000845)1.89677657
93Arnold-Chiari malformation (HP:0002308)1.89409659
94Down-sloping shoulders (HP:0200021)1.88927724
95Buphthalmos (HP:0000557)1.88358510
96Atrophic scars (HP:0001075)1.86759506
97Patellar dislocation (HP:0002999)1.86677640
98Long palpebral fissure (HP:0000637)1.85845310
99Depression (HP:0000716)1.85596370
100Urinary urgency (HP:0000012)1.84968490
101Abnormal respiratory motile cilium morphology (HP:0005938)1.84226946
102Abnormal respiratory epithelium morphology (HP:0012253)1.84226946
103Asymmetric septal hypertrophy (HP:0001670)1.84168413
104Sparse lateral eyebrow (HP:0005338)1.83390260
105Abnormality of oral frenula (HP:0000190)1.81935180
106Metaphyseal cupping (HP:0003021)1.81388195
107Abnormal ciliary motility (HP:0012262)1.80671498
108Flared metaphyses (HP:0003015)1.80663238
109Fragile skin (HP:0001030)1.80485372
110Amyotrophic lateral sclerosis (HP:0007354)1.79539713
111Genetic anticipation (HP:0003743)1.79498809
112Cellulitis (HP:0100658)1.79446590
113Biconcave vertebral bodies (HP:0004586)1.79383640
114Dysmetric saccades (HP:0000641)1.79294372
115Vascular tortuosity (HP:0004948)1.78941771
116Interstitial pulmonary disease (HP:0006530)1.78647949
117Pseudobulbar signs (HP:0002200)1.77789215
118Double outlet right ventricle (HP:0001719)1.77730259
119Congenital malformation of the right heart (HP:0011723)1.77730259
120Impaired social interactions (HP:0000735)1.77476206
121Abnormal social behavior (HP:0012433)1.77476206
122Infertility (HP:0000789)1.75864057
123Increased IgE level (HP:0003212)1.75720414
124Ventricular fibrillation (HP:0001663)1.74873357
125Abnormality of the thoracic spine (HP:0100711)1.73640779
126Supranuclear gaze palsy (HP:0000605)1.72841849
127Dilatation of the ascending aorta (HP:0005111)1.72769944
128Torticollis (HP:0000473)1.70570650
129Cerebral inclusion bodies (HP:0100314)1.69178981
130Reticulocytosis (HP:0001923)1.67873406
131Urethral obstruction (HP:0000796)1.67712559
132Abnormality of the parathyroid morphology (HP:0011766)1.67706868
133Insidious onset (HP:0003587)1.67602334
134Termporal pattern (HP:0011008)1.67602334
135Self-mutilation (HP:0000742)1.66860463
136Bicuspid aortic valve (HP:0001647)1.66400566
137Focal motor seizures (HP:0011153)1.66101090
138Precocious puberty (HP:0000826)1.65830572
139Subacute progressive viral hepatitis (HP:0006572)1.65581850
140Aplasia/Hypoplasia of the earlobes (HP:0009906)1.65048178
141Megalocornea (HP:0000485)1.62917354
142Hypertriglyceridemia (HP:0002155)1.62670808
143Difficulty climbing stairs (HP:0003551)1.62010613
144Aplasia involving bones of the upper limbs (HP:0009823)1.61874293
145Aplasia of the phalanges of the hand (HP:0009802)1.61874293
146Aplasia involving bones of the extremities (HP:0009825)1.61874293
147Difficulty running (HP:0009046)1.61609840
148Bowed forearm bones (HP:0003956)1.61539683
149Bowing of the arm (HP:0006488)1.61539683
150Distal lower limb muscle weakness (HP:0009053)1.61441272
151Unilateral renal agenesis (HP:0000122)1.60607522
152Abnormal ventriculo-arterial connection (HP:0011563)1.60575735
153Transposition of the great arteries (HP:0001669)1.60575735
154Abnormal connection of the cardiac segments (HP:0011545)1.60575735
155Polycystic kidney dysplasia (HP:0000113)1.60356053
156Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.59939250
157Hepatoblastoma (HP:0002884)1.59903503
158Abnormal vertebral ossification (HP:0100569)1.59839604
159Recurrent otitis media (HP:0000403)1.59796320
160Hemiparesis (HP:0001269)1.58730266
161Polygenic inheritance (HP:0010982)1.58646919
162Premature skin wrinkling (HP:0100678)1.58416105
163Hypertensive crisis (HP:0100735)1.58285151
164Abnormality of the phalanges of the hallux (HP:0010057)1.58264027
165Striae distensae (HP:0001065)1.58073430
166Dislocated radial head (HP:0003083)1.57832126
167Papilledema (HP:0001085)1.57776788
168Intellectual disability, profound (HP:0002187)1.57747523
169Stereotypic behavior (HP:0000733)1.57502598
170Abnormality of the radial head (HP:0003995)1.55426500
171Sacral dimple (HP:0000960)1.55390046
172Urinary bladder sphincter dysfunction (HP:0002839)1.55114656
173Abnormality of the epiphyses of the hand (HP:0005924)1.53292931
174Achilles tendon contracture (HP:0001771)1.52867131
175Increased nuchal translucency (HP:0010880)1.51938750
176Poor eye contact (HP:0000817)1.51664367
177Disproportionate tall stature (HP:0001519)1.51642803
178Bundle branch block (HP:0011710)1.51497122
179Ependymoma (HP:0002888)1.51488876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.45525588
2TRIB33.36579806
3PRKD33.06776681
4MST1R2.60559421
5FGFR42.52684210
6PKN22.44257287
7PRPF4B2.37720813
8NME22.29519589
9RIPK12.24345853
10ICK2.20885606
11EEF2K2.19488582
12MAP3K92.15097825
13EPHA42.13383432
14MAP3K101.93844476
15PAK61.90994537
16MARK11.88936150
17DAPK21.86229867
18NTRK31.85283408
19MAPK151.77268627
20KSR11.76442920
21MAP3K21.68919743
22CAMKK11.67731789
23PAK31.66458383
24SIK21.66011608
25MAP2K31.63143350
26EPHA21.61776552
27PDGFRA1.61553522
28MAP3K71.61486045
29KSR21.58902375
30SIK11.58390276
31TYRO31.56613279
32EPHB21.55587136
33LMTK21.49373429
34MINK11.49100241
35MAP3K131.45357770
36PTK61.43170284
37NTRK21.41860126
38CAMK1G1.40168941
39STK381.40073550
40TTN1.34791767
41NTRK11.32211912
42PDK41.31569592
43PDK31.31569592
44TAOK11.29341424
45BMX1.27703926
46IRAK31.27473921
47TESK11.27386769
48DDR21.25134209
49CDK71.22449891
50BRD41.21935389
51PRKCI1.19503431
52MARK21.18252643
53MAP3K41.17461523
54LATS21.14582687
55PHKG21.12195263
56PHKG11.12195263
57MATK1.11962669
58RPS6KA21.11450219
59CDC42BPA1.03999211
60ALK1.01468702
61UHMK10.98650133
62PTK20.97179879
63MTOR0.96104011
64PTK2B0.94614136
65ILK0.94388859
66MAPK110.94289320
67CDK40.94268291
68ERBB20.94213542
69MAP4K10.93055389
70TNK20.92636654
71RET0.92134229
72GRK60.90050714
73CDK50.87211387
74MET0.86225260
75CAMK1D0.85776161
76NME10.84386712
77MAP2K60.84297436
78LATS10.83203036
79PAK40.82901847
80FER0.82106382
81RPS6KC10.81499255
82RPS6KL10.81499255
83PRKD20.81438956
84PRKCH0.81286265
85MAP2K40.81059633
86TESK20.79723465
87PAK20.78933017
88SCYL20.78780303
89TBK10.78281758
90BRSK10.77817954
91CDK80.77106771
92DMPK0.76286463
93NEK10.74137635
94STK110.73980277
95MAP3K30.73790010
96MAP3K60.72505086
97SGK30.71126618
98FGFR20.70528856
99PLK40.69952517
100FGFR10.68354359
101PDPK10.66452650
102TYK20.65355144
103PNCK0.65036648
104CDK190.64482256
105CAMK40.64305034
106ERN10.64097757
107DYRK1B0.62761927
108MAP3K110.62363669
109PDK10.62333899
110CAMK10.62300300
111RPS6KA60.61451658
112MAP3K10.60061606
113CDK150.59628278
114PRKCZ0.59125620
115CDK180.58275760
116ARAF0.56032965
117TAOK20.55769127
118DAPK10.54295744
119CDK120.53882668
120LRRK20.53334816
121RPS6KA30.51798657
122CDK90.51427010
123CDK60.50469112
124CDK11A0.50400268
125PDGFRB0.48776720
126MAP3K80.48502582
127CDK140.48479162
128AKT20.47522083
129PRKCG0.47444584
130MAPK120.47058186
131ROCK10.46978781
132HIPK20.46216608
133MAP2K20.46038335
134CDK20.45106964
135NEK60.45007409
136MAPK80.44880125
137WNK10.44739627
138RPS6KA10.44584110
139SGK10.43432654
140CDK30.43094299
141NEK20.42637397
142SGK2230.42277506
143SGK4940.42277506
144BRAF0.41814454
145MAPK100.41302832
146AURKA0.41112690
147TLK10.40635475
148CHEK10.40611855
149JAK30.40136908
150ATR0.39971969
151FGFR30.39157503
152ZAP700.37976978
153RPS6KB20.37162620
154MELK0.35849704
155CDK10.35468205
156RIPK40.34910933

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.33831004
2Sulfur relay system_Homo sapiens_hsa041222.14397960
3Nitrogen metabolism_Homo sapiens_hsa009102.10023913
4Acute myeloid leukemia_Homo sapiens_hsa052212.07702831
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.95749860
6Olfactory transduction_Homo sapiens_hsa047401.91368964
7Circadian entrainment_Homo sapiens_hsa047131.75188420
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64597395
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63700453
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.60743194
11Long-term potentiation_Homo sapiens_hsa047201.57992804
12Glioma_Homo sapiens_hsa052141.57226979
13Amphetamine addiction_Homo sapiens_hsa050311.56158577
14Synaptic vesicle cycle_Homo sapiens_hsa047211.52883576
15Fructose and mannose metabolism_Homo sapiens_hsa000511.52732851
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49791390
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49417679
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48764671
19Estrogen signaling pathway_Homo sapiens_hsa049151.48442005
20B cell receptor signaling pathway_Homo sapiens_hsa046621.48362670
21DNA replication_Homo sapiens_hsa030301.43876952
22Gastric acid secretion_Homo sapiens_hsa049711.43553035
23GABAergic synapse_Homo sapiens_hsa047271.40799977
24Dopaminergic synapse_Homo sapiens_hsa047281.39884040
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36075252
26Glutamatergic synapse_Homo sapiens_hsa047241.36008490
27Insulin secretion_Homo sapiens_hsa049111.35656480
28Nicotine addiction_Homo sapiens_hsa050331.32627624
29Cholinergic synapse_Homo sapiens_hsa047251.32248892
30mTOR signaling pathway_Homo sapiens_hsa041501.31617347
31Salivary secretion_Homo sapiens_hsa049701.31015369
32Base excision repair_Homo sapiens_hsa034101.30712730
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30018994
34Endometrial cancer_Homo sapiens_hsa052131.29732444
35Glucagon signaling pathway_Homo sapiens_hsa049221.28076646
36Axon guidance_Homo sapiens_hsa043601.27122090
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.26470330
38Basal cell carcinoma_Homo sapiens_hsa052171.24949763
39Dorso-ventral axis formation_Homo sapiens_hsa043201.24585673
40ABC transporters_Homo sapiens_hsa020101.23895156
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23624434
42Oxytocin signaling pathway_Homo sapiens_hsa049211.23515139
43Chronic myeloid leukemia_Homo sapiens_hsa052201.21625162
44Type II diabetes mellitus_Homo sapiens_hsa049301.21602662
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21378016
46Gap junction_Homo sapiens_hsa045401.20749410
47Melanogenesis_Homo sapiens_hsa049161.20163950
48Thyroid hormone signaling pathway_Homo sapiens_hsa049191.19778113
49Morphine addiction_Homo sapiens_hsa050321.19608298
50Inositol phosphate metabolism_Homo sapiens_hsa005621.19015008
51Hippo signaling pathway_Homo sapiens_hsa043901.17387116
52ErbB signaling pathway_Homo sapiens_hsa040121.16613628
53Colorectal cancer_Homo sapiens_hsa052101.15002790
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.14110059
55GnRH signaling pathway_Homo sapiens_hsa049121.13336334
56Cocaine addiction_Homo sapiens_hsa050301.11965653
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10731014
58Prostate cancer_Homo sapiens_hsa052151.09943717
59Non-small cell lung cancer_Homo sapiens_hsa052231.09893310
60Renin secretion_Homo sapiens_hsa049241.09820335
61Glycerophospholipid metabolism_Homo sapiens_hsa005641.09445462
62Central carbon metabolism in cancer_Homo sapiens_hsa052301.08444358
63Dilated cardiomyopathy_Homo sapiens_hsa054141.07124896
64VEGF signaling pathway_Homo sapiens_hsa043701.06976419
65Small cell lung cancer_Homo sapiens_hsa052221.05611096
66Hedgehog signaling pathway_Homo sapiens_hsa043401.05144235
67Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.04368135
68Galactose metabolism_Homo sapiens_hsa000521.04080113
69Proteoglycans in cancer_Homo sapiens_hsa052051.03653003
70Bile secretion_Homo sapiens_hsa049761.01854109
71Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01708917
72Renal cell carcinoma_Homo sapiens_hsa052111.01465563
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.01417013
74Viral carcinogenesis_Homo sapiens_hsa052031.00307394
75cAMP signaling pathway_Homo sapiens_hsa040241.00145622
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99418488
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.98387658
78Focal adhesion_Homo sapiens_hsa045100.97128048
79Thyroid cancer_Homo sapiens_hsa052160.95196568
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.93919267
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.92052753
82Notch signaling pathway_Homo sapiens_hsa043300.91893144
83Phospholipase D signaling pathway_Homo sapiens_hsa040720.90910437
84Oocyte meiosis_Homo sapiens_hsa041140.90423323
85Insulin signaling pathway_Homo sapiens_hsa049100.90236885
86Phenylalanine metabolism_Homo sapiens_hsa003600.89900514
87mRNA surveillance pathway_Homo sapiens_hsa030150.89761520
88Lysine degradation_Homo sapiens_hsa003100.89554764
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88292643
90Hepatitis B_Homo sapiens_hsa051610.88279411
91Wnt signaling pathway_Homo sapiens_hsa043100.87658178
92Bladder cancer_Homo sapiens_hsa052190.86619089
93RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85603859
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.85372335
95Hepatitis C_Homo sapiens_hsa051600.84719512
96Calcium signaling pathway_Homo sapiens_hsa040200.84280055
97Biosynthesis of amino acids_Homo sapiens_hsa012300.84166717
98HTLV-I infection_Homo sapiens_hsa051660.83355077
99Choline metabolism in cancer_Homo sapiens_hsa052310.82909268
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80819200
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80604568
102Pentose phosphate pathway_Homo sapiens_hsa000300.79593632
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79112371
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78959357
105Insulin resistance_Homo sapiens_hsa049310.78836019
106Fatty acid biosynthesis_Homo sapiens_hsa000610.78730536
107AMPK signaling pathway_Homo sapiens_hsa041520.78590087
108Rap1 signaling pathway_Homo sapiens_hsa040150.76695428
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74930197
110Tight junction_Homo sapiens_hsa045300.74108443
111T cell receptor signaling pathway_Homo sapiens_hsa046600.73869289
112Thyroid hormone synthesis_Homo sapiens_hsa049180.73534049
113Cell cycle_Homo sapiens_hsa041100.73212550
114Long-term depression_Homo sapiens_hsa047300.71823855
115Adherens junction_Homo sapiens_hsa045200.71566065
116MAPK signaling pathway_Homo sapiens_hsa040100.70269946
117Osteoclast differentiation_Homo sapiens_hsa043800.68697039
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68496628
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68303617
120Apoptosis_Homo sapiens_hsa042100.67898723
121Pancreatic cancer_Homo sapiens_hsa052120.67777708
122Influenza A_Homo sapiens_hsa051640.67401338
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.65885245
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.65832783
125HIF-1 signaling pathway_Homo sapiens_hsa040660.65379761
126MicroRNAs in cancer_Homo sapiens_hsa052060.65167581
127Prolactin signaling pathway_Homo sapiens_hsa049170.65078473
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.64583000
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.63370535
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.61219935
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60068566
132Endocytosis_Homo sapiens_hsa041440.60006397
133Taste transduction_Homo sapiens_hsa047420.59021844
134Arginine biosynthesis_Homo sapiens_hsa002200.58577200
135Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58178797
136Herpes simplex infection_Homo sapiens_hsa051680.57389389
137ECM-receptor interaction_Homo sapiens_hsa045120.57204266
138Epstein-Barr virus infection_Homo sapiens_hsa051690.54801087
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54792932
140N-Glycan biosynthesis_Homo sapiens_hsa005100.54043154
141Pathways in cancer_Homo sapiens_hsa052000.54005266
142TNF signaling pathway_Homo sapiens_hsa046680.53166168
143Toxoplasmosis_Homo sapiens_hsa051450.52014973
144Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50842014
145Prion diseases_Homo sapiens_hsa050200.50049921
146Fanconi anemia pathway_Homo sapiens_hsa034600.49413748
147Alcoholism_Homo sapiens_hsa050340.49390969

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