FBL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.02823182
2formation of translation preinitiation complex (GO:0001731)4.60685917
3folic acid-containing compound biosynthetic process (GO:0009396)4.55818347
4protein localization to kinetochore (GO:0034501)4.47623233
5maturation of SSU-rRNA (GO:0030490)4.34356571
6ribosomal small subunit assembly (GO:0000028)4.27427252
7viral transcription (GO:0019083)4.24716412
8DNA strand elongation involved in DNA replication (GO:0006271)4.17306475
9translational termination (GO:0006415)4.16392250
10nuclear pore organization (GO:0006999)4.16293240
11DNA replication initiation (GO:0006270)4.15399510
12mitotic nuclear envelope disassembly (GO:0007077)4.07086608
13negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.03757565
14nuclear pore complex assembly (GO:0051292)3.97241361
15DNA strand elongation (GO:0022616)3.96510387
16IMP biosynthetic process (GO:0006188)3.95036933
17establishment of integrated proviral latency (GO:0075713)3.87482363
18nucleobase biosynthetic process (GO:0046112)3.87326896
19translational initiation (GO:0006413)3.80600724
20translation (GO:0006412)3.79766463
21translational elongation (GO:0006414)3.79677840
22membrane disassembly (GO:0030397)3.76833100
23nuclear envelope disassembly (GO:0051081)3.76833100
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.76203830
25protein localization to chromosome, centromeric region (GO:0071459)3.74637049
26negative regulation of RNA splicing (GO:0033119)3.73130532
27ribosomal small subunit biogenesis (GO:0042274)3.72947625
28telomere maintenance via semi-conservative replication (GO:0032201)3.72148076
29ribosome biogenesis (GO:0042254)3.67803502
30protein targeting to membrane (GO:0006612)3.67061136
31heterochromatin organization (GO:0070828)3.65051406
32DNA replication-dependent nucleosome organization (GO:0034723)3.64802727
33DNA replication-dependent nucleosome assembly (GO:0006335)3.64802727
34regulation of translational fidelity (GO:0006450)3.61883524
35ribonucleoprotein complex biogenesis (GO:0022613)3.58103583
36DNA duplex unwinding (GO:0032508)3.53999911
37cellular component biogenesis (GO:0044085)3.53598597
38negative regulation of mRNA processing (GO:0050686)3.52358726
39DNA geometric change (GO:0032392)3.51510644
40IMP metabolic process (GO:0046040)3.47476508
41regulation of mitochondrial translation (GO:0070129)3.45839478
42ribosomal large subunit biogenesis (GO:0042273)3.43896017
43ribosome assembly (GO:0042255)3.43403431
44mitotic sister chromatid segregation (GO:0000070)3.41733719
45regulation of posttranscriptional gene silencing (GO:0060147)3.40543594
46regulation of gene silencing by miRNA (GO:0060964)3.40543594
47regulation of gene silencing by RNA (GO:0060966)3.40543594
48DNA replication checkpoint (GO:0000076)3.37178421
49pre-miRNA processing (GO:0031054)3.32051126
50SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.31864039
51dosage compensation (GO:0007549)3.29259965
52purine nucleobase biosynthetic process (GO:0009113)3.28918370
53mitotic metaphase plate congression (GO:0007080)3.26989918
54nucleobase-containing small molecule interconversion (GO:0015949)3.26952614
55cellular protein complex disassembly (GO:0043624)3.24869173
56telomere maintenance via recombination (GO:0000722)3.24781544
57viral life cycle (GO:0019058)3.24177205
58protein targeting to ER (GO:0045047)3.23407413
59viral mRNA export from host cell nucleus (GO:0046784)3.22698216
60DNA topological change (GO:0006265)3.22547252
61sister chromatid segregation (GO:0000819)3.20533974
62cotranslational protein targeting to membrane (GO:0006613)3.19977219
63negative regulation of mRNA metabolic process (GO:1903312)3.16430403
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15373641
65mitotic recombination (GO:0006312)3.15042137
66peptidyl-arginine omega-N-methylation (GO:0035247)3.15011348
67mitotic chromosome condensation (GO:0007076)3.13583265
68* rRNA processing (GO:0006364)3.12740993
69protein complex disassembly (GO:0043241)3.10926023
70regulation of translational termination (GO:0006449)3.09318708
71RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.08714157
72mRNA splicing, via spliceosome (GO:0000398)3.08714157
73rRNA transcription (GO:0009303)3.08628465
74RNA splicing, via transesterification reactions (GO:0000375)3.08513955
75proline biosynthetic process (GO:0006561)3.07843573
76establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06380358
77positive regulation of chromosome segregation (GO:0051984)3.06266248
78pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.04834833
79telomere maintenance via telomere lengthening (GO:0010833)3.03055842
80* rRNA metabolic process (GO:0016072)3.02704727
81establishment of viral latency (GO:0019043)3.02634256
82histone H2B ubiquitination (GO:0033523)3.02474932
83nuclear-transcribed mRNA catabolic process (GO:0000956)3.02205766
84nuclear envelope organization (GO:0006998)3.00901317
85pore complex assembly (GO:0046931)2.99715713
86DNA deamination (GO:0045006)2.99509558
87regulation of histone H3-K9 methylation (GO:0051570)2.98788909
88regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.98521126
89protein localization to endoplasmic reticulum (GO:0070972)2.98101962
90pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.98100255
91chromosome condensation (GO:0030261)2.97609070
92chromatin assembly (GO:0031497)2.97312978
93somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95701230
94somatic hypermutation of immunoglobulin genes (GO:0016446)2.95701230
95termination of RNA polymerase II transcription (GO:0006369)2.95113537
96ncRNA 3-end processing (GO:0043628)2.94892153
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.92182932
98RNA catabolic process (GO:0006401)2.91955364
99negative regulation of histone methylation (GO:0031061)2.91852417
100spliceosomal snRNP assembly (GO:0000387)2.91580292
101protein complex localization (GO:0031503)2.89209185
102nucleotide-excision repair, DNA gap filling (GO:0006297)2.89062985
103pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.88687278
104spliceosomal tri-snRNP complex assembly (GO:0000244)2.88634688
105macromolecular complex disassembly (GO:0032984)2.88259868
106mRNA catabolic process (GO:0006402)2.87993195
107metaphase plate congression (GO:0051310)2.83258546
108histone arginine methylation (GO:0034969)2.82800147
109DNA conformation change (GO:0071103)2.82528656
110RNA stabilization (GO:0043489)2.82475423
111mRNA stabilization (GO:0048255)2.82475423
1123-UTR-mediated mRNA stabilization (GO:0070935)2.81951885
113pseudouridine synthesis (GO:0001522)2.81809535
114negative regulation of DNA-templated transcription, elongation (GO:0032785)2.79277307
115mRNA transport (GO:0051028)2.78107316
116regulation of spindle organization (GO:0090224)2.75567174
117UTP biosynthetic process (GO:0006228)2.74640165
118chromatin assembly or disassembly (GO:0006333)2.74424121
119ribonucleoprotein complex assembly (GO:0022618)2.73174532
120mitotic G1 DNA damage checkpoint (GO:0031571)2.72638022
121pteridine-containing compound biosynthetic process (GO:0042559)2.72224812
122chromatin remodeling at centromere (GO:0031055)2.71861429
123RNA export from nucleus (GO:0006405)2.70524353
124CENP-A containing nucleosome assembly (GO:0034080)2.70259664
125transcription from mitochondrial promoter (GO:0006390)2.69208889
126L-serine metabolic process (GO:0006563)2.68906873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.99922960
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11870314
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.94132070
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68709096
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17855931
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01656756
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.80144292
8MYC_22102868_ChIP-Seq_BL_Human2.69404516
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.62783982
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60913276
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.51331745
12* XRN2_22483619_ChIP-Seq_HELA_Human2.24558995
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.18599705
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.17583430
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07976372
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92244778
17CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91850109
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86055915
19* E2F1_21310950_ChIP-Seq_MCF-7_Human1.82119252
20GABP_17652178_ChIP-ChIP_JURKAT_Human1.80462155
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76074078
22AR_21909140_ChIP-Seq_LNCAP_Human1.74115796
23VDR_23849224_ChIP-Seq_CD4+_Human1.74046174
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71219862
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70929616
26MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.69772372
27CIITA_25753668_ChIP-Seq_RAJI_Human1.69225526
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68224252
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67853678
30VDR_21846776_ChIP-Seq_THP-1_Human1.67685058
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.66295238
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65224705
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64635434
34FOXP3_21729870_ChIP-Seq_TREG_Human1.63483844
35TTF2_22483619_ChIP-Seq_HELA_Human1.62476177
36* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60918817
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.60862384
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58513823
39GABP_19822575_ChIP-Seq_HepG2_Human1.58023704
40STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57629235
41DCP1A_22483619_ChIP-Seq_HELA_Human1.56410364
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55077361
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54670907
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.51833860
45KDM5A_27292631_Chip-Seq_BREAST_Human1.51812366
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50563543
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44507069
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40989806
49TP63_19390658_ChIP-ChIP_HaCaT_Human1.40391464
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40373929
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.34421687
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33290870
53KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32949407
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.32868475
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31627384
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31627384
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31627384
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31150144
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29845503
60* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26037307
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24570133
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23337967
63CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23034417
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.22953353
65PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.22903832
66TFEB_21752829_ChIP-Seq_HELA_Human1.19691990
67* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19316592
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18206150
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.16945801
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.16549122
71ELK1_19687146_ChIP-ChIP_HELA_Human1.11800962
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09890340
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09824068
74* TET1_21451524_ChIP-Seq_MESCs_Mouse1.08093544
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06509847
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06340925
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.06200230
78* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05864737
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04822143
80SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04512412
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04444046
82TCF7_22412390_ChIP-Seq_EML_Mouse1.04390861
83LXR_22292898_ChIP-Seq_THP-1_Human1.03972635
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03749864
85NANOG_21062744_ChIP-ChIP_HESCs_Human1.02117369
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01329646
87SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00821215
88* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.00709153
89RACK7_27058665_Chip-Seq_MCF-7_Human1.00659255
90ELK3_25401928_ChIP-Seq_HUVEC_Human0.99068943
91UTX_26944678_Chip-Seq_JUKART_Human0.98871732
92HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98765721
93SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98358519
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98302673
95* SRF_21415370_ChIP-Seq_HL-1_Mouse0.98262560
96NCOR1_26117541_ChIP-Seq_K562_Human0.98191415
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96564499
98* MAF_26560356_Chip-Seq_TH1_Human0.96355913
99* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96058425
100FOXP1_21924763_ChIP-Seq_HESCs_Human0.95721928
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94595588
102CHD1_26751641_Chip-Seq_LNCaP_Human0.93397422
103* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93190978
104* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92953020
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92681900
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.91775594
107ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91331376
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90375287
109SPI1_23547873_ChIP-Seq_NB4_Human0.89994896
110OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89843367
111* CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89795989
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89235869
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89012317
114* P68_20966046_ChIP-Seq_HELA_Human0.88819024
115SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.87939129
116ZNF263_19887448_ChIP-Seq_K562_Human0.87231427
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86013353
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85831561
119TP63_17297297_ChIP-ChIP_HaCaT_Human0.85820114
120ATF3_27146783_Chip-Seq_COLON_Human0.84781282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.29539685
2MP0009379_abnormal_foot_pigmentation3.94397658
3MP0004957_abnormal_blastocyst_morpholog3.93782596
4MP0003111_abnormal_nucleus_morphology3.93208328
5MP0010094_abnormal_chromosome_stability3.75481443
6MP0008057_abnormal_DNA_replication3.75279016
7MP0003077_abnormal_cell_cycle3.44695972
8MP0010352_gastrointestinal_tract_polyps2.96459649
9MP0004185_abnormal_adipocyte_glucose2.95051183
10MP0002396_abnormal_hematopoietic_system2.48613631
11* MP0001730_embryonic_growth_arrest2.38881497
12MP0008007_abnormal_cellular_replicative2.32565893
13MP0008058_abnormal_DNA_repair2.31614939
14MP0000350_abnormal_cell_proliferation2.26859480
15MP0008932_abnormal_embryonic_tissue2.11059214
16MP0003123_paternal_imprinting2.07961029
17MP0010307_abnormal_tumor_latency2.05295104
18MP0005380_embryogenesis_phenotype1.94806162
19MP0001672_abnormal_embryogenesis/_devel1.94806162
20MP0005451_abnormal_body_composition1.92371589
21MP0005076_abnormal_cell_differentiation1.92255793
22MP0000490_abnormal_crypts_of1.83462228
23MP0001697_abnormal_embryo_size1.83177205
24MP0003984_embryonic_growth_retardation1.80943657
25MP0003705_abnormal_hypodermis_morpholog1.80447062
26MP0006292_abnormal_olfactory_placode1.77699641
27MP0002088_abnormal_embryonic_growth/wei1.77684263
28MP0004197_abnormal_fetal_growth/weight/1.76993744
29MP0000678_abnormal_parathyroid_gland1.76885883
30MP0002084_abnormal_developmental_patter1.75125092
31MP0002086_abnormal_extraembryonic_tissu1.71121421
32MP0002085_abnormal_embryonic_tissue1.70960512
33MP0004808_abnormal_hematopoietic_stem1.67145125
34* MP0002080_prenatal_lethality1.67059338
35MP0009278_abnormal_bone_marrow1.63565752
36MP0010030_abnormal_orbit_morphology1.62452490
37MP0003786_premature_aging1.58762563
38MP0001545_abnormal_hematopoietic_system1.47755271
39MP0005397_hematopoietic_system_phenotyp1.47755271
40MP0002796_impaired_skin_barrier1.46025884
41MP0009333_abnormal_splenocyte_physiolog1.45615477
42MP0003890_abnormal_embryonic-extraembry1.45351380
43MP0002019_abnormal_tumor_incidence1.44157534
44MP0000313_abnormal_cell_death1.43259198
45MP0003763_abnormal_thymus_physiology1.40815018
46MP0003567_abnormal_fetal_cardiomyocyte1.39705066
47MP0004233_abnormal_muscle_weight1.37755397
48MP0005666_abnormal_adipose_tissue1.32530126
49MP0002163_abnormal_gland_morphology1.31507058
50MP0009053_abnormal_anal_canal1.29473474
51MP0000703_abnormal_thymus_morphology1.29139838
52MP0008877_abnormal_DNA_methylation1.28765423
53MP0001293_anophthalmia1.24249957
54MP0002249_abnormal_larynx_morphology1.22651008
55MP0002653_abnormal_ependyma_morphology1.22494630
56MP0001727_abnormal_embryo_implantation1.22286344
57MP0002398_abnormal_bone_marrow1.22098599
58MP0006035_abnormal_mitochondrial_morpho1.20667763
59MP0003566_abnormal_cell_adhesion1.19403325
60MP0009697_abnormal_copulation1.18691489
61MP0003121_genomic_imprinting1.16260563
62MP0002722_abnormal_immune_system1.15859315
63MP0003119_abnormal_digestive_system1.15205675
64MP0001849_ear_inflammation1.14438438
65MP0001873_stomach_inflammation1.14189984
66MP0001661_extended_life_span1.13870354
67MP0004264_abnormal_extraembryonic_tissu1.13255857
68MP0000689_abnormal_spleen_morphology1.08801729
69MP0005023_abnormal_wound_healing1.05256095
70MP0000566_synostosis1.04204957
71MP0003186_abnormal_redox_activity1.02323360
72MP0000537_abnormal_urethra_morphology1.01279376
73MP0001346_abnormal_lacrimal_gland1.00953791
74MP0000858_altered_metastatic_potential0.96713642
75MP0009672_abnormal_birth_weight0.96668885
76MP0003806_abnormal_nucleotide_metabolis0.95560400
77MP0002429_abnormal_blood_cell0.92208734
78MP0002111_abnormal_tail_morphology0.91139740
79MP0006036_abnormal_mitochondrial_physio0.90571056
80MP0008995_early_reproductive_senescence0.90449423
81MP0000685_abnormal_immune_system0.89527866
82MP0001915_intracranial_hemorrhage0.89037472
83MP0001881_abnormal_mammary_gland0.87776684
84MP0000477_abnormal_intestine_morphology0.86976005
85MP0002092_abnormal_eye_morphology0.84607130
86MP0000733_abnormal_muscle_development0.84537806
87MP0003453_abnormal_keratinocyte_physiol0.83193756
88MP0009703_decreased_birth_body0.82507121
89MP0000428_abnormal_craniofacial_morphol0.82480139
90MP0002210_abnormal_sex_determination0.81613695
91MP0002877_abnormal_melanocyte_morpholog0.80940534
92MP0000716_abnormal_immune_system0.79957201
93MP0003942_abnormal_urinary_system0.79786453
94MP0000049_abnormal_middle_ear0.78801121
95MP0001145_abnormal_male_reproductive0.78198701
96MP0002405_respiratory_system_inflammati0.77609117
97MP0003718_maternal_effect0.77182111
98MP0004133_heterotaxia0.76644264
99MP0001800_abnormal_humoral_immune0.75599614
100MP0005621_abnormal_cell_physiology0.75573513
101MP0002697_abnormal_eye_size0.74732540
102MP0005384_cellular_phenotype0.74693220
103MP0005375_adipose_tissue_phenotype0.73133432
104MP0000358_abnormal_cell_content/0.72345691
105MP0005501_abnormal_skin_physiology0.72311057
106MP0008770_decreased_survivor_rate0.71304623
107MP0001853_heart_inflammation0.71223203
108MP0002925_abnormal_cardiovascular_devel0.70860406
109MP0002009_preneoplasia0.70800486
110MP0003315_abnormal_perineum_morphology0.70756656
111MP0004858_abnormal_nervous_system0.66945304
112MP0001188_hyperpigmentation0.64939653
113MP0001348_abnormal_lacrimal_gland0.64797661
114MP0003303_peritoneal_inflammation0.64717374
115MP0003115_abnormal_respiratory_system0.62862720
116MP0003283_abnormal_digestive_organ0.62667626
117MP0003221_abnormal_cardiomyocyte_apopto0.62664493
118MP0002089_abnormal_postnatal_growth/wei0.62283342
119MP0006054_spinal_hemorrhage0.62163906
120MP0010155_abnormal_intestine_physiology0.61656323
121MP0003385_abnormal_body_wall0.61540657
122MP0001286_abnormal_eye_development0.61386151
123MP0001929_abnormal_gametogenesis0.61203951
124MP0000432_abnormal_head_morphology0.60944171
125MP0008260_abnormal_autophagy0.60211593
126MP0000627_abnormal_mammary_gland0.60049580
127MP0003935_abnormal_craniofacial_develop0.60035088
128MP0003941_abnormal_skin_development0.59969566
129MP0003937_abnormal_limbs/digits/tail_de0.59776819
130MP0003448_altered_tumor_morphology0.59170930
131MP0003300_gastrointestinal_ulcer0.58332514
132MP0002420_abnormal_adaptive_immunity0.58302013
133MP0002452_abnormal_antigen_presenting0.58206974
134MP0000653_abnormal_sex_gland0.57738590
135MP0001819_abnormal_immune_cell0.57380331

Predicted human phenotypes

RankGene SetZ-score
1Progressive muscle weakness (HP:0003323)4.18907089
2Reticulocytopenia (HP:0001896)3.99635989
3Aplasia/Hypoplasia of the sacrum (HP:0008517)3.97638641
4Ependymoma (HP:0002888)3.93399522
5Abnormality of cells of the erythroid lineage (HP:0012130)3.78925812
6Selective tooth agenesis (HP:0001592)3.61931286
7Microvesicular hepatic steatosis (HP:0001414)3.59443999
8Abnormal number of erythroid precursors (HP:0012131)3.48105519
9Birth length less than 3rd percentile (HP:0003561)3.17536670
10Medulloblastoma (HP:0002885)3.13615520
11Colon cancer (HP:0003003)3.03771339
12Basal cell carcinoma (HP:0002671)2.87835665
13Abnormality of the anterior horn cell (HP:0006802)2.76836669
14Degeneration of anterior horn cells (HP:0002398)2.76836669
15Patellar aplasia (HP:0006443)2.74931767
16Chromsome breakage (HP:0040012)2.72549845
17Rhabdomyosarcoma (HP:0002859)2.72207621
18Oral leukoplakia (HP:0002745)2.70254806
19Astrocytoma (HP:0009592)2.65772640
20Abnormality of the astrocytes (HP:0100707)2.65772640
21Breast hypoplasia (HP:0003187)2.65021083
22Proximal placement of thumb (HP:0009623)2.63068903
23Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62120313
24Abnormal number of incisors (HP:0011064)2.60600391
25Aplasia/Hypoplasia of the patella (HP:0006498)2.59575027
26Deviation of the thumb (HP:0009603)2.57442116
27Absent thumb (HP:0009777)2.56192881
28Multiple enchondromatosis (HP:0005701)2.55797268
29Agnosia (HP:0010524)2.53572083
30Trismus (HP:0000211)2.49799095
31Pallor (HP:0000980)2.48118635
32Ragged-red muscle fibers (HP:0003200)2.47542782
33Broad distal phalanx of finger (HP:0009836)2.42785451
34Aplastic anemia (HP:0001915)2.41898145
35Increased nuchal translucency (HP:0010880)2.40131103
36Macrocytic anemia (HP:0001972)2.40049786
37Carpal bone hypoplasia (HP:0001498)2.38472502
38Rib fusion (HP:0000902)2.37880319
39Myelodysplasia (HP:0002863)2.36388354
40Thrombocytosis (HP:0001894)2.35525107
41Progressive external ophthalmoplegia (HP:0000590)2.35191766
42Neoplasm of the pancreas (HP:0002894)2.34470456
43Missing ribs (HP:0000921)2.33379705
44Truncus arteriosus (HP:0001660)2.33275048
45Neoplasm of striated muscle (HP:0009728)2.32684743
46Abnormality of cochlea (HP:0000375)2.31666149
47Abnormality of the ileum (HP:0001549)2.26604437
48Absent radius (HP:0003974)2.26418646
49Rough bone trabeculation (HP:0100670)2.26272043
50Meckel diverticulum (HP:0002245)2.25477651
51Glioma (HP:0009733)2.24818375
52Septate vagina (HP:0001153)2.24639047
53Neonatal hypoglycemia (HP:0001998)2.24456587
54Horseshoe kidney (HP:0000085)2.24169847
55Abnormality of glycolysis (HP:0004366)2.23035346
56Squamous cell carcinoma (HP:0002860)2.22314855
57Atresia of the external auditory canal (HP:0000413)2.21321913
58Neoplasm of the oral cavity (HP:0100649)2.20984871
59Abnormality of chromosome stability (HP:0003220)2.19969702
60Prominent nose (HP:0000448)2.18780780
61Amaurosis fugax (HP:0100576)2.16964426
62Abnormality of the labia minora (HP:0012880)2.15180860
63Cleft eyelid (HP:0000625)2.10819383
64Duplication of thumb phalanx (HP:0009942)2.10381449
65Biliary tract neoplasm (HP:0100574)2.09887585
66Gout (HP:0001997)2.09762686
67Absent forearm bone (HP:0003953)2.09043399
68Aplasia involving forearm bones (HP:0009822)2.09043399
69Testicular atrophy (HP:0000029)2.07616817
70Abnormality of the preputium (HP:0100587)2.07484389
71Facial cleft (HP:0002006)2.06195373
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.04427040
73Malignant gastrointestinal tract tumors (HP:0006749)2.02687812
74Gastrointestinal carcinoma (HP:0002672)2.02687812
75Cholecystitis (HP:0001082)2.02103625
76Abnormal gallbladder physiology (HP:0012438)2.02103625
77Preauricular skin tag (HP:0000384)2.01741595
78Skin tags (HP:0010609)2.01369338
7911 pairs of ribs (HP:0000878)2.00979273
80Tracheoesophageal fistula (HP:0002575)1.98784748
81High pitched voice (HP:0001620)1.98000940
82Microretrognathia (HP:0000308)1.97790747
83Abnormality of reticulocytes (HP:0004312)1.97471160
84Increased hepatocellular lipid droplets (HP:0006565)1.96290827
85Volvulus (HP:0002580)1.96189180
86Aplasia/hypoplasia of the humerus (HP:0006507)1.95931279
87Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.95860087
88Impulsivity (HP:0100710)1.94954106
89Hyperthyroidism (HP:0000836)1.94597636
90Facial hemangioma (HP:0000329)1.94201203
91Poikiloderma (HP:0001029)1.93368528
92Respiratory difficulties (HP:0002880)1.93089910
93Cafe-au-lait spot (HP:0000957)1.92457291
94Abnormal mitochondria in muscle tissue (HP:0008316)1.92315851
95Hyperacusis (HP:0010780)1.91888152
96Pseudobulbar signs (HP:0002200)1.90695597
97Seborrheic dermatitis (HP:0001051)1.90177345
98Duodenal stenosis (HP:0100867)1.90056347
99Small intestinal stenosis (HP:0012848)1.90056347
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.89179917
101IgM deficiency (HP:0002850)1.88317528
102Premature ovarian failure (HP:0008209)1.87945510
103Premature graying of hair (HP:0002216)1.87883179
104Pancytopenia (HP:0001876)1.87459689
105Asplenia (HP:0001746)1.87310049
106Deep palmar crease (HP:0006191)1.85881874
107Overlapping toe (HP:0001845)1.84849730
108Ectopic kidney (HP:0000086)1.83674440
109Insomnia (HP:0100785)1.81812138
110Achilles tendon contracture (HP:0001771)1.81761848
111Adenoma sebaceum (HP:0009720)1.81709562
112Angiofibromas (HP:0010615)1.81709562
113Aplasia/Hypoplasia of the spleen (HP:0010451)1.81516959
114Hypertensive crisis (HP:0100735)1.79857571
115Bone marrow hypocellularity (HP:0005528)1.79450188
116Atrophy/Degeneration involving motor neurons (HP:0007373)1.79364567
117Esophageal atresia (HP:0002032)1.78763004
118Renal duplication (HP:0000075)1.78699512
119Abnormality of the fingertips (HP:0001211)1.78555728
120Lymphoma (HP:0002665)1.78408330
121Abnormality of the calcaneus (HP:0008364)1.77389698
122Acute necrotizing encephalopathy (HP:0006965)1.76465218
123Increased serum pyruvate (HP:0003542)1.75289808
124Short middle phalanx of the 5th finger (HP:0004220)1.74139804
125Aplasia/Hypoplasia of the thymus (HP:0010515)1.74007474
126Nasolacrimal duct obstruction (HP:0000579)1.73964878
127Sparse eyelashes (HP:0000653)1.73815371
128Short humerus (HP:0005792)1.73491592
129Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.73068791
130Decreased activity of mitochondrial respiratory chain (HP:0008972)1.73068791
131Long eyelashes (HP:0000527)1.72073283
132Short 4th metacarpal (HP:0010044)1.71910659
133Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71910659
134Ulnar bowing (HP:0003031)1.71308515
135Increased intramyocellular lipid droplets (HP:0012240)1.71298217
136Acute lymphatic leukemia (HP:0006721)1.71140799
137High anterior hairline (HP:0009890)1.71078123
138Acute encephalopathy (HP:0006846)1.70708151
139Lipid accumulation in hepatocytes (HP:0006561)1.70531685
140Increased density of long bones (HP:0006392)1.69772309
141Broad palm (HP:0001169)1.69352685
142Partial duplication of thumb phalanx (HP:0009944)1.68498659
143Cutaneous melanoma (HP:0012056)1.68299105
144Overriding aorta (HP:0002623)1.67428818
145Reticulocytosis (HP:0001923)1.64654871
146Abnormality of the umbilical cord (HP:0010881)1.63698896
147Choanal atresia (HP:0000453)1.63307055
148Triphalangeal thumb (HP:0001199)1.63077033
149Hypergonadotropic hypogonadism (HP:0000815)1.62204892
150Increased serum lactate (HP:0002151)1.62127314
151Exercise intolerance (HP:0003546)1.61660363
152Patellar dislocation (HP:0002999)1.61616994
153Glossoptosis (HP:0000162)1.61566592
154Secondary amenorrhea (HP:0000869)1.61275459
155Abnormal trabecular bone morphology (HP:0100671)1.57573489
156Abnormality of DNA repair (HP:0003254)1.56548191
157Morphological abnormality of the inner ear (HP:0011390)1.55617845
158Increased muscle lipid content (HP:0009058)1.52309108

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.71462291
2EEF2K3.62174950
3SMG13.59519490
4CDC73.58886632
5CDK123.35089997
6BUB13.01937603
7WEE12.86769035
8NEK22.70358353
9MAP3K102.44425267
10IRAK32.43215692
11NME22.37224947
12RPS6KB22.26090621
13PKN22.23100061
14PASK2.22528354
15TSSK62.08761679
16CDK71.96767559
17TTK1.92436522
18TRIB31.84117151
19PBK1.83807006
20STK101.81706167
21NEK11.77978164
22MAP4K11.77594392
23CDK41.71024763
24TESK21.66459323
25EPHA21.55099447
26PRPF4B1.53696403
27SRPK11.51873695
28ATR1.51659483
29PLK11.50157019
30ALK1.49179673
31MKNK11.45764102
32TAF11.44834502
33STK161.44727594
34RPS6KA41.44670555
35EIF2AK11.42902888
36MAP3K81.39473363
37TGFBR11.38283692
38PAK41.37310181
39AURKB1.36225602
40DYRK31.33148948
41NME11.31739992
42FLT31.30341215
43CHEK11.28607784
44LRRK21.26275479
45ACVR1B1.24698103
46SCYL21.20696080
47CHEK21.17778901
48PIM11.16047549
49CDK191.13268472
50BRSK21.09335170
51ICK1.08946880
52GRK61.08232953
53PIM21.05398601
54MTOR1.04266957
55CDK61.04037721
56BRD41.03527139
57BRAF1.02352594
58MKNK21.00684232
59CDK90.97164898
60EIF2AK30.96130119
61CDK20.93784055
62PLK40.93211000
63AURKA0.90012910
64SIK10.87993994
65MAP2K30.85558353
66ERN10.85074646
67ATM0.82011666
68STK40.80654203
69PLK30.78052099
70MAP3K110.77197797
71ARAF0.76264073
72PAK20.73223202
73ZAP700.71398612
74MAPKAPK30.71174606
75BTK0.70943467
76BMX0.70405715
77STK30.68791031
78CSNK2A20.68610158
79VRK10.67228328
80DMPK0.66988306
81PAK10.64992615
82CSF1R0.64066833
83PTK60.62899396
84TLK10.62196705
85AKT20.61960752
86BRSK10.58442224
87CDK10.58055847
88JAK30.55942564
89KDR0.55858199
90LATS20.53213785
91IRAK20.52657647
92ILK0.50534277
93CSNK2A10.50171025
94BCKDK0.50139188
95CDK80.49275022
96FGFR10.48166537
97CSNK1E0.48014748
98CHUK0.47221371
99ZAK0.47077821
100RPS6KA10.45702618
101PRKCI0.44991746
102CLK10.44670005
103TAOK20.42620011
104LATS10.42035380
105FGFR40.41934262
106MELK0.41734430
107TAOK10.41116622
108MAPK110.40518376
109MAP2K20.39405225
110RPS6KL10.39168811
111RPS6KC10.39168811
112DAPK10.38938229
113CDK11A0.38681394
114MAPKAPK20.38593306
115PDGFRA0.37912630
116RPS6KA60.37621925
117IRAK40.36211682
118TTN0.36058346
119MST1R0.35440955
120MAPK140.34624414
121PRKDC0.33937596
122TESK10.33842805
123DAPK30.31641975
124EIF2AK20.29639197
125PRKD30.29485688
126KSR20.28967381
127RPS6KA50.28008719

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.52568425
2Mismatch repair_Homo sapiens_hsa034304.05363035
3* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.54725205
4Spliceosome_Homo sapiens_hsa030403.46274299
5Ribosome_Homo sapiens_hsa030103.38529219
6RNA transport_Homo sapiens_hsa030133.22340839
7One carbon pool by folate_Homo sapiens_hsa006703.13828485
8Base excision repair_Homo sapiens_hsa034102.90218460
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.69661620
10Cell cycle_Homo sapiens_hsa041102.54777335
11Nucleotide excision repair_Homo sapiens_hsa034202.41185652
12Homologous recombination_Homo sapiens_hsa034402.38589877
13RNA polymerase_Homo sapiens_hsa030202.35750037
14mRNA surveillance pathway_Homo sapiens_hsa030152.14288379
15Proteasome_Homo sapiens_hsa030501.97166465
16Pyrimidine metabolism_Homo sapiens_hsa002401.86078813
17Fanconi anemia pathway_Homo sapiens_hsa034601.73270408
18RNA degradation_Homo sapiens_hsa030181.71282123
19p53 signaling pathway_Homo sapiens_hsa041151.55496596
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50809796
21Non-homologous end-joining_Homo sapiens_hsa034501.50219970
22Basal transcription factors_Homo sapiens_hsa030221.37398214
23Parkinsons disease_Homo sapiens_hsa050121.31874635
24Oxidative phosphorylation_Homo sapiens_hsa001901.23204949
25Huntingtons disease_Homo sapiens_hsa050161.23202888
26Epstein-Barr virus infection_Homo sapiens_hsa051691.20359079
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.19788240
28Antigen processing and presentation_Homo sapiens_hsa046121.18854597
29Viral carcinogenesis_Homo sapiens_hsa052031.15782672
30Herpes simplex infection_Homo sapiens_hsa051681.15127808
31Biosynthesis of amino acids_Homo sapiens_hsa012301.07280384
32Selenocompound metabolism_Homo sapiens_hsa004501.04637053
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02631671
34HTLV-I infection_Homo sapiens_hsa051661.01554674
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.96682736
36Notch signaling pathway_Homo sapiens_hsa043300.95539007
37MicroRNAs in cancer_Homo sapiens_hsa052060.95200658
38Chronic myeloid leukemia_Homo sapiens_hsa052200.94411153
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94192559
40Thyroid cancer_Homo sapiens_hsa052160.92764749
41Pyruvate metabolism_Homo sapiens_hsa006200.92623530
42Sulfur relay system_Homo sapiens_hsa041220.91567954
43Primary immunodeficiency_Homo sapiens_hsa053400.91179141
44Pentose phosphate pathway_Homo sapiens_hsa000300.90666405
45Small cell lung cancer_Homo sapiens_hsa052220.90484792
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.84518611
47Acute myeloid leukemia_Homo sapiens_hsa052210.83199170
48Systemic lupus erythematosus_Homo sapiens_hsa053220.80380471
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79533534
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.79273319
51Legionellosis_Homo sapiens_hsa051340.77260590
52Bladder cancer_Homo sapiens_hsa052190.76540022
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75270674
54Purine metabolism_Homo sapiens_hsa002300.74538828
55Colorectal cancer_Homo sapiens_hsa052100.70259248
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69852859
57Apoptosis_Homo sapiens_hsa042100.68851972
58mTOR signaling pathway_Homo sapiens_hsa041500.66923853
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.66822525
60Basal cell carcinoma_Homo sapiens_hsa052170.66762061
61Hippo signaling pathway_Homo sapiens_hsa043900.66125340
62Alzheimers disease_Homo sapiens_hsa050100.65620369
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.64724628
64Folate biosynthesis_Homo sapiens_hsa007900.64300877
65Lysine degradation_Homo sapiens_hsa003100.64111827
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63959888
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.61997485
68Oocyte meiosis_Homo sapiens_hsa041140.61706280
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60034603
70Shigellosis_Homo sapiens_hsa051310.59851272
71Measles_Homo sapiens_hsa051620.59234107
72Hepatitis B_Homo sapiens_hsa051610.58607164
73Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57314858
74Glutathione metabolism_Homo sapiens_hsa004800.56720924
75TGF-beta signaling pathway_Homo sapiens_hsa043500.54425321
76Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52341082
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50414915
78B cell receptor signaling pathway_Homo sapiens_hsa046620.49535403
79Non-small cell lung cancer_Homo sapiens_hsa052230.48108331
80Carbon metabolism_Homo sapiens_hsa012000.46896500
81Adherens junction_Homo sapiens_hsa045200.46881535
82Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45008895
83HIF-1 signaling pathway_Homo sapiens_hsa040660.44257880
84Viral myocarditis_Homo sapiens_hsa054160.41217252
85Fatty acid elongation_Homo sapiens_hsa000620.40798251
86Pathways in cancer_Homo sapiens_hsa052000.40721415
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40664992
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39750636
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39732656
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39610270
91Proteoglycans in cancer_Homo sapiens_hsa052050.38289692
92Renal cell carcinoma_Homo sapiens_hsa052110.37883426
93Fructose and mannose metabolism_Homo sapiens_hsa000510.37009603
94Influenza A_Homo sapiens_hsa051640.36998560
95Hedgehog signaling pathway_Homo sapiens_hsa043400.36899509
96T cell receptor signaling pathway_Homo sapiens_hsa046600.36563369
97Arginine and proline metabolism_Homo sapiens_hsa003300.35643817
98VEGF signaling pathway_Homo sapiens_hsa043700.35122180
99Pancreatic cancer_Homo sapiens_hsa052120.35112525
100Metabolic pathways_Homo sapiens_hsa011000.33758622
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.32836117
102Prostate cancer_Homo sapiens_hsa052150.32434372
103Leishmaniasis_Homo sapiens_hsa051400.31818906
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31669162
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30578045
106Melanoma_Homo sapiens_hsa052180.29788615
107N-Glycan biosynthesis_Homo sapiens_hsa005100.28868638
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28422664
109Hematopoietic cell lineage_Homo sapiens_hsa046400.28214105
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27569038
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27546144
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27331778
113Endometrial cancer_Homo sapiens_hsa052130.26700593
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.26616905
115Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26193349
116Wnt signaling pathway_Homo sapiens_hsa043100.26183444
117Galactose metabolism_Homo sapiens_hsa000520.26118185
118Glioma_Homo sapiens_hsa052140.26104304
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.25312268
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24774652
121Vitamin B6 metabolism_Homo sapiens_hsa007500.24773585
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23210688
123Alcoholism_Homo sapiens_hsa050340.23027321
124Insulin signaling pathway_Homo sapiens_hsa049100.22523328
125Toxoplasmosis_Homo sapiens_hsa051450.21966864
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.21809595
127ErbB signaling pathway_Homo sapiens_hsa040120.20526375
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20038664

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