FBLIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein with an N-terminal filamin-binding domain, a central proline-rich domain, and, multiple C-terminal LIM domains. This protein localizes at cell junctions and may link cell adhesion structures to the actin cytoskeleton. This protein may be involved in the assembly and stabilization of actin-filaments and likely plays a role in modulating cell adhesion, cell morphology and cell motility. This protein also localizes to the nucleus and may affect cardiomyocyte differentiation after binding with the CSX/NKX2-5 transcription factor. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.23343095
2cardiac myofibril assembly (GO:0055003)5.84497541
3endodermal cell differentiation (GO:0035987)5.10886592
4bundle of His cell to Purkinje myocyte communication (GO:0086069)5.00769380
5lymphangiogenesis (GO:0001946)4.99882400
6myofibril assembly (GO:0030239)4.93689083
7cardiac muscle cell development (GO:0055013)4.78247558
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.65959736
9cardiac cell development (GO:0055006)4.62765656
10paraxial mesoderm development (GO:0048339)4.54828423
11plasma membrane repair (GO:0001778)4.52553855
12cell adhesion mediated by integrin (GO:0033627)4.39775873
13positive regulation of SMAD protein import into nucleus (GO:0060391)4.14116387
14negative regulation of potassium ion transmembrane transport (GO:1901380)4.13147695
15regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.08013489
16ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.02599772
17actomyosin structure organization (GO:0031032)3.98314935
18negative regulation of chondrocyte differentiation (GO:0032331)3.97362631
19chondrocyte proliferation (GO:0035988)3.95265086
20protein heterotrimerization (GO:0070208)3.90783327
21regulation of SMAD protein import into nucleus (GO:0060390)3.89802333
22blood vessel maturation (GO:0001955)3.88284159
23regulation of gene silencing by RNA (GO:0060966)3.87733012
24regulation of posttranscriptional gene silencing (GO:0060147)3.87733012
25regulation of gene silencing by miRNA (GO:0060964)3.87733012
26cardiac muscle tissue morphogenesis (GO:0055008)3.87603861
27muscle filament sliding (GO:0030049)3.87442767
28actin-myosin filament sliding (GO:0033275)3.87442767
29apoptotic process involved in morphogenesis (GO:0060561)3.80848518
30skin morphogenesis (GO:0043589)3.80813610
31endothelium development (GO:0003158)3.77594227
32regulation of cardioblast differentiation (GO:0051890)3.77135984
33ventricular cardiac muscle cell action potential (GO:0086005)3.76634927
34sequestering of extracellular ligand from receptor (GO:0035581)3.73489615
35cardiac muscle contraction (GO:0060048)3.73057286
36endothelial cell morphogenesis (GO:0001886)3.66222346
37negative regulation of keratinocyte proliferation (GO:0010839)3.62887157
38collagen fibril organization (GO:0030199)3.56312781
39regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.55333579
40epithelial cell-cell adhesion (GO:0090136)3.53650828
41heart trabecula formation (GO:0060347)3.49181577
42retina vasculature morphogenesis in camera-type eye (GO:0061299)3.47922040
43glomerular filtration (GO:0003094)3.43495099
44cell migration involved in heart development (GO:0060973)3.43001691
45endocardial cushion development (GO:0003197)3.41469637
46muscle tissue morphogenesis (GO:0060415)3.41034666
47ventricular cardiac muscle cell development (GO:0055015)3.39540004
48regulation of tight junction assembly (GO:2000810)3.39347890
49substrate-dependent cell migration (GO:0006929)3.38715193
50regulation of hippo signaling (GO:0035330)3.37096006
51positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.33796412
52regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.33748832
53artery development (GO:0060840)3.33510783
54adult heart development (GO:0007512)3.32615520
55regulation of skeletal muscle contraction (GO:0014819)3.30874425
56actin-mediated cell contraction (GO:0070252)3.27656661
57regulation of transforming growth factor beta2 production (GO:0032909)3.25979863
58tricarboxylic acid cycle (GO:0006099)3.23760864
59substrate adhesion-dependent cell spreading (GO:0034446)3.21413235
60extracellular matrix disassembly (GO:0022617)3.19148790
61wound healing, spreading of cells (GO:0044319)3.18676784
62collagen metabolic process (GO:0032963)3.14531607
63mesodermal cell differentiation (GO:0048333)3.11343601
64cardiac muscle hypertrophy (GO:0003300)3.10140318
65multicellular organismal macromolecule metabolic process (GO:0044259)3.09631196
66cellular response to vitamin D (GO:0071305)3.06177714
67cellular response to vitamin (GO:0071295)3.05671502
68multicellular organismal catabolic process (GO:0044243)3.04860978
69adhesion of symbiont to host cell (GO:0044650)3.04532934
70virion attachment to host cell (GO:0019062)3.04532934
71collagen catabolic process (GO:0030574)3.03921725
72notochord development (GO:0030903)3.03914321
73negative regulation of axon extension involved in axon guidance (GO:0048843)3.00615825
74regulation of transforming growth factor beta1 production (GO:0032908)3.00462310
75regulation of actin filament-based movement (GO:1903115)3.00061941
76multicellular organismal metabolic process (GO:0044236)3.00007778
77cell migration involved in sprouting angiogenesis (GO:0002042)2.97441654
78axon extension involved in axon guidance (GO:0048846)2.95850382
79neuron projection extension involved in neuron projection guidance (GO:1902284)2.95850382
80regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.90871207
81desmosome organization (GO:0002934)2.90316125
82negative regulation of striated muscle cell apoptotic process (GO:0010664)2.90249694
83smooth muscle tissue development (GO:0048745)2.89313942
84negative regulation of cartilage development (GO:0061037)2.88997914
85actin filament depolymerization (GO:0030042)2.87684607
86keratinocyte proliferation (GO:0043616)2.86663991
87bone trabecula formation (GO:0060346)2.85456551
88striated muscle hypertrophy (GO:0014897)2.85190944
89regulation of chondrocyte differentiation (GO:0032330)2.84704064
90apoptotic process involved in development (GO:1902742)2.82971740
91regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.82121033
92sprouting angiogenesis (GO:0002040)2.82052175
93regulation of sarcomere organization (GO:0060297)2.81678788
94trophectodermal cell differentiation (GO:0001829)2.81258744
95heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.79905889
96regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.79626158
97regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.79138926
98anterior/posterior axis specification, embryo (GO:0008595)2.79134561
99heterochromatin organization (GO:0070828)2.77102489
100semaphorin-plexin signaling pathway (GO:0071526)2.75838854
101establishment of apical/basal cell polarity (GO:0035089)2.74717694
102vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.74685033
103positive regulation of cartilage development (GO:0061036)2.72889617
104wound healing, spreading of epidermal cells (GO:0035313)2.72344062
105regulation of keratinocyte proliferation (GO:0010837)2.72329912
106vascular endothelial growth factor signaling pathway (GO:0038084)2.70610419
107actin filament-based movement (GO:0030048)2.70568607
108muscle hypertrophy (GO:0014896)2.70499717
109trabecula formation (GO:0060343)2.70292151
110extracellular matrix organization (GO:0030198)2.70161278
111extracellular structure organization (GO:0043062)2.69336488
112regulation of axon extension involved in axon guidance (GO:0048841)2.69079630
113regulation of cartilage development (GO:0061035)2.68829570
114heart process (GO:0003015)2.66846269
115heart contraction (GO:0060047)2.66846269
116negative regulation of protein localization to cell surface (GO:2000009)2.66699792
117extracellular matrix assembly (GO:0085029)2.65822632
118ventricular trabecula myocardium morphogenesis (GO:0003222)2.65619432
119negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.65163588
120nuclear pore organization (GO:0006999)2.64298902
121* cell junction assembly (GO:0034329)2.63927225
122renal system process involved in regulation of blood volume (GO:0001977)2.63110459
123regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62715800
124basement membrane organization (GO:0071711)2.62585628
125cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.62114998
126type B pancreatic cell proliferation (GO:0044342)2.61752855
127atrioventricular valve morphogenesis (GO:0003181)2.61134084
128cell-substrate junction assembly (GO:0007044)2.61115765
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.60562608
130glomerular visceral epithelial cell development (GO:0072015)2.59662058
131negative regulation of fatty acid transport (GO:2000192)2.57851891
132positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57437956
133regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57327240
134heart trabecula morphogenesis (GO:0061384)2.57212334
135dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.56958140
136striated muscle contraction (GO:0006941)2.56539493
137regulation of relaxation of muscle (GO:1901077)2.56084918
138negative regulation of androgen receptor signaling pathway (GO:0060766)2.55806884
139hippo signaling (GO:0035329)2.54689167
140regulation of G0 to G1 transition (GO:0070316)2.54562086
141polarized epithelial cell differentiation (GO:0030859)2.54002151
142regulation of glomerular filtration (GO:0003093)2.53203869
143trabecula morphogenesis (GO:0061383)2.52682417
144positive regulation of endothelial cell apoptotic process (GO:2000353)2.52359385
145venous blood vessel morphogenesis (GO:0048845)2.51162396
146endothelial cell proliferation (GO:0001935)2.51066064
147establishment of planar polarity (GO:0001736)2.49956072
148establishment of tissue polarity (GO:0007164)2.49956072
149adhesion of symbiont to host (GO:0044406)2.49360334
150hemidesmosome assembly (GO:0031581)2.49341730
151cardiac muscle cell action potential involved in contraction (GO:0086002)2.48410531
152fibroblast migration (GO:0010761)2.48396075
153cardiac muscle cell action potential (GO:0086001)2.47786824
154nuclear pore complex assembly (GO:0051292)2.47752580
155regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.47151061
156neural crest cell development (GO:0014032)2.46054417
157* cell junction organization (GO:0034330)2.45216982
158regulation of the force of heart contraction (GO:0002026)2.44788027
159carnitine shuttle (GO:0006853)2.42369781
160neuron remodeling (GO:0016322)2.42295548
161regulation of mitotic spindle organization (GO:0060236)2.41652090
162negative regulation of adherens junction organization (GO:1903392)2.41443728
163negative regulation of focal adhesion assembly (GO:0051895)2.41443728
164negative regulation of cell junction assembly (GO:1901889)2.41443728
165outflow tract septum morphogenesis (GO:0003148)2.41052988
166striated muscle cell development (GO:0055002)2.40802545
167cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.40390066
168growth hormone secretion (GO:0030252)2.40000295
169gap junction assembly (GO:0016264)2.39701030
170regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.39464267
171regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.35589993
172regulation of striated muscle cell apoptotic process (GO:0010662)2.35396360
173mRNA transcription (GO:0009299)2.35278281
174adherens junction assembly (GO:0034333)2.33853491
175regulation of striated muscle contraction (GO:0006942)2.32176838
176protein hydroxylation (GO:0018126)2.31967504
177developmental programmed cell death (GO:0010623)2.30910532
178glomerular basement membrane development (GO:0032836)2.30209460
179cell communication involved in cardiac conduction (GO:0086065)2.28947075
180renal filtration (GO:0097205)2.28873712
181embryonic camera-type eye development (GO:0031076)2.28872350
182polyketide metabolic process (GO:0030638)2.26978770
183doxorubicin metabolic process (GO:0044598)2.26978770
184daunorubicin metabolic process (GO:0044597)2.26978770

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.72410164
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.11904119
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.69687257
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.17306652
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.17306652
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.17306652
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.13088465
8POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.89942368
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.89283783
10* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.78506132
11* SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.75681514
12STAT3_1855785_ChIP-Seq_MESCs_Mouse2.50006810
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.48286618
14ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.41003150
15ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.40249372
16NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.40124374
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38271224
18TCF3_18692474_ChIP-Seq_MEFs_Mouse2.35065098
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.33313878
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.28752343
21GATA2_21666600_ChIP-Seq_HMVEC_Human2.25860959
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23578744
23CJUN_26792858_Chip-Seq_BT549_Human2.20562887
24NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.15032467
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.14439892
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14426048
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11193515
28SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.05922048
29TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86994283
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.86863672
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86488217
32ZNF263_19887448_ChIP-Seq_K562_Human1.86125617
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84539448
34FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82340420
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.82147776
36BRD4_25478319_ChIP-Seq_HGPS_Human1.81015548
37* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.77120203
38* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.75738471
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71579246
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.70043670
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.68190034
42SOX2_18555785_ChIP-Seq_MESCs_Mouse1.66731316
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.65011633
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64693389
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61416237
46CDX2_20551321_ChIP-Seq_CACO-2_Human1.58665940
47SOX2_20726797_ChIP-Seq_SW620_Human1.57381285
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57189623
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.55200173
50EP300_21415370_ChIP-Seq_HL-1_Mouse1.53741810
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.53637187
52EED_16625203_ChIP-ChIP_MESCs_Mouse1.51995120
53ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51866377
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51353987
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51138297
56TBX20_22328084_ChIP-Seq_HEART_Mouse1.50957440
57TBX20_22080862_ChIP-Seq_HEART_Mouse1.50957440
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.48734005
59* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.48670195
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48249869
61RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.46401607
62NANOG_18692474_ChIP-Seq_MEFs_Mouse1.46020452
63* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45755790
64TP53_18474530_ChIP-ChIP_U2OS_Human1.45712942
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45194282
66NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.44652191
67AR_21909140_ChIP-Seq_LNCAP_Human1.43848964
68CLOCK_20551151_ChIP-Seq_293T_Human1.43632990
69ATF3_27146783_Chip-Seq_COLON_Human1.43167636
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.43020238
71TP53_22127205_ChIP-Seq_IMR90_Human1.40719388
72KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40719268
73SALL1_21062744_ChIP-ChIP_HESCs_Human1.39477660
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38397985
75* ELK3_25401928_ChIP-Seq_HUVEC_Human1.38203465
76OCT4_18692474_ChIP-Seq_MEFs_Mouse1.37478135
77NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.37401374
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34682072
79GATA4_21415370_ChIP-Seq_HL-1_Mouse1.34537688
80TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31300033
81* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30056693
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29783707
83POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29577592
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29278018
85RNF2_18974828_ChIP-Seq_MESCs_Mouse1.29023105
86EZH2_18974828_ChIP-Seq_MESCs_Mouse1.29023105
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.28935180
88* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.28022350
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27880900
90SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.26939034
91EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.26402713
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.25579721
93NANOG_18692474_ChIP-Seq_MESCs_Mouse1.25023697
94GATA4_25053715_ChIP-Seq_YYC3_Human1.24192523
95* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22859920
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22348557
97TP53_16413492_ChIP-PET_HCT116_Human1.22119810
98NANOG_21062744_ChIP-ChIP_HESCs_Human1.21212350
99* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.20483017
100TP63_23658742_ChIP-Seq_EP156T_Human1.20139126
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.19965078
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19769534
103CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18961978
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18960878
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.18101399
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.17882921
107CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17533541
108* UBF1/2_26484160_Chip-Seq_HMECs_Human1.17103753
109NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16100333
110CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14253770
111BP1_19119308_ChIP-ChIP_Hs578T_Human1.13956125
112TP63_19390658_ChIP-ChIP_HaCaT_Human1.13578509
113* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.13345836
114ESR1_15608294_ChIP-ChIP_MCF-7_Human1.13341059
115TP53_23651856_ChIP-Seq_MEFs_Mouse1.13217592
116SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13152877
117P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12922938
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12094688
119RACK7_27058665_Chip-Seq_MCF-7_Human1.11956816
120* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11314935
121* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11210832
122* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11210832
123SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10508795
124POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10015434
125KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09241344
126* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09195246
127* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.08693862
128WT1_19549856_ChIP-ChIP_CCG9911_Human1.07819315
129SMAD3_21741376_ChIP-Seq_HESCs_Human1.07538220
130PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.07049035
131* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06293534
132SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06027799
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06027799
134AHR_22903824_ChIP-Seq_MCF-7_Human1.05636398
135SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.04988633
136HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04817151
137TCF4_18268006_ChIP-ChIP_LS174T_Human1.04637145
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04087081
139SALL4_18804426_ChIP-ChIP_XEN_Mouse1.03616238
140MYC_22102868_ChIP-Seq_BL_Human1.02759983
141STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.02111204
142PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01863502
143MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00823023
144* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00739693
145ISL1_27105846_Chip-Seq_CPCs_Mouse1.00614728
146MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99711129
147SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99254254
148TFEB_21752829_ChIP-Seq_HELA_Human0.99250807
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98967317
150* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.98438916
151E2F1_21310950_ChIP-Seq_MCF-7_Human0.98334582
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.96989012
153* CTCF_27219007_Chip-Seq_Bcells_Human0.96296919
154ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.94595976
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93811518
156* TP63_22573176_ChIP-Seq_HFKS_Human0.91901828
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91785622
158* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.88742253
159* TET1_21490601_ChIP-Seq_MESCs_Mouse0.88281944
160PIAS1_25552417_ChIP-Seq_VCAP_Human0.87361922
161TP53_20018659_ChIP-ChIP_R1E_Mouse0.86404155
162SA1_22415368_ChIP-Seq_MEFs_Mouse0.86325169
163SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85499228
164EZH2_27294783_Chip-Seq_ESCs_Mouse0.85163923
165ARNT_22903824_ChIP-Seq_MCF-7_Human0.84097134
166KLF5_25053715_ChIP-Seq_YYC3_Human0.83749976
167PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83156837
168PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82868967
169ERG_21242973_ChIP-ChIP_JURKAT_Human0.81943034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle4.40563586
2MP0002837_dystrophic_cardiac_calcinosis3.77298036
3MP0003646_muscle_fatigue3.05135567
4MP0000751_myopathy2.93234325
5MP0004215_abnormal_myocardial_fiber2.84714506
6MP0005330_cardiomyopathy2.67540071
7MP0000750_abnormal_muscle_regeneration2.52937696
8MP0003566_abnormal_cell_adhesion2.42837799
9MP0003705_abnormal_hypodermis_morpholog2.42337373
10MP0000579_abnormal_nail_morphology2.42059928
11MP0004036_abnormal_muscle_relaxation2.35352928
12MP0008775_abnormal_heart_ventricle2.26571991
13MP0010630_abnormal_cardiac_muscle2.22616391
14MP0003828_pulmonary_edema2.20376852
15MP0003941_abnormal_skin_development2.19899927
16MP0008438_abnormal_cutaneous_collagen2.16242567
17MP0004087_abnormal_muscle_fiber2.11397200
18MP0002972_abnormal_cardiac_muscle2.09543135
19MP0005360_urolithiasis2.08269739
20MP0000762_abnormal_tongue_morphology2.04726840
21MP0000013_abnormal_adipose_tissue2.04153767
22MP0009384_cardiac_valve_regurgitation2.02652280
23MP0001544_abnormal_cardiovascular_syste2.02433044
24MP0005385_cardiovascular_system_phenoty2.02433044
25MP0000749_muscle_degeneration2.01390593
26MP0003567_abnormal_fetal_cardiomyocyte1.96856816
27MP0002060_abnormal_skin_morphology1.92779031
28MP0010352_gastrointestinal_tract_polyps1.90490233
29MP0003137_abnormal_impulse_conducting1.90486499
30MP0006138_congestive_heart_failure1.90420345
31MP0000467_abnormal_esophagus_morphology1.87640959
32MP0003279_aneurysm1.82412741
33MP0002254_reproductive_system_inflammat1.79587675
34MP0005623_abnormal_meninges_morphology1.69261158
35MP0003950_abnormal_plasma_membrane1.64605670
36MP0002127_abnormal_cardiovascular_syste1.58619666
37MP0002106_abnormal_muscle_physiology1.55405925
38MP0005620_abnormal_muscle_contractility1.53383094
39MP0004484_altered_response_of1.53374422
40MP0005409_darkened_coat_color1.52821650
41MP0010234_abnormal_vibrissa_follicle1.52122420
42MP0010030_abnormal_orbit_morphology1.51938498
43MP0002269_muscular_atrophy1.50547038
44MP0004272_abnormal_basement_membrane1.48760282
45MP0010368_abnormal_lymphatic_system1.45469028
46MP0003984_embryonic_growth_retardation1.43724459
47MP0005595_abnormal_vascular_smooth1.43563603
48MP0002088_abnormal_embryonic_growth/wei1.41828104
49MP0002796_impaired_skin_barrier1.41806517
50MP0004233_abnormal_muscle_weight1.41536491
51MP0005275_abnormal_skin_tensile1.39246024
52MP0001672_abnormal_embryogenesis/_devel1.38030496
53MP0005380_embryogenesis_phenotype1.38030496
54MP0000462_abnormal_digestive_system1.37911131
55MP0003221_abnormal_cardiomyocyte_apopto1.37617963
56MP0000538_abnormal_urinary_bladder1.36860078
57MP0002295_abnormal_pulmonary_circulatio1.36088323
58MP0004858_abnormal_nervous_system1.32475467
59MP0000266_abnormal_heart_morphology1.31248370
60MP0003693_abnormal_embryo_hatching1.30402524
61MP0004957_abnormal_blastocyst_morpholog1.29641859
62MP0001542_abnormal_bone_strength1.29404522
63MP0005369_muscle_phenotype1.28079516
64MP0009780_abnormal_chondrocyte_physiolo1.27120502
65MP0003123_paternal_imprinting1.25958039
66MP0001299_abnormal_eye_distance/1.25667230
67MP0000767_abnormal_smooth_muscle1.23906048
68MP0005076_abnormal_cell_differentiation1.21406835
69MP0000759_abnormal_skeletal_muscle1.21008272
70MP0003111_abnormal_nucleus_morphology1.20228856
71MP0000678_abnormal_parathyroid_gland1.20174175
72MP0003878_abnormal_ear_physiology1.19340810
73MP0005377_hearing/vestibular/ear_phenot1.19340810
74MP0000733_abnormal_muscle_development1.19194732
75MP0005023_abnormal_wound_healing1.18863943
76MP0002896_abnormal_bone_mineralization1.18107031
77MP0000343_altered_response_to1.16056941
78MP0000049_abnormal_middle_ear1.14754447
79MP0002925_abnormal_cardiovascular_devel1.14747768
80MP0003077_abnormal_cell_cycle1.13813504
81MP0002086_abnormal_extraembryonic_tissu1.13255718
82MP0005367_renal/urinary_system_phenotyp1.12200921
83MP0000516_abnormal_urinary_system1.12200921
84MP0004085_abnormal_heartbeat1.12191832
85MP0001879_abnormal_lymphatic_vessel1.10399500
86MP0009250_abnormal_appendicular_skeleto1.08314062
87MP0004133_heterotaxia1.08312712
88MP0001849_ear_inflammation1.08292225
89MP0002085_abnormal_embryonic_tissue1.07610352
90MP0005257_abnormal_intraocular_pressure1.05409911
91MP0003755_abnormal_palate_morphology1.04754281
92MP0004197_abnormal_fetal_growth/weight/1.02945076
93MP0001697_abnormal_embryo_size1.02156068
94MP0005503_abnormal_tendon_morphology1.01870685
95MP0001730_embryonic_growth_arrest1.01713890
96MP0000003_abnormal_adipose_tissue1.01188656
97MP0001958_emphysema1.00786829
98MP0005501_abnormal_skin_physiology1.00230456
99MP0000566_synostosis1.00019039
100MP0009278_abnormal_bone_marrow0.99186924
101MP0001243_abnormal_dermal_layer0.99024533
102MP0002128_abnormal_blood_circulation0.98574508
103MP0004510_myositis0.98288157
104MP0002084_abnormal_developmental_patter0.97380036
105MP0003385_abnormal_body_wall0.96210733
106MP0001216_abnormal_epidermal_layer0.95664358
107MP0005666_abnormal_adipose_tissue0.94580875
108MP0000534_abnormal_ureter_morphology0.93740312
109MP0004185_abnormal_adipocyte_glucose0.93324798
110MP0010771_integument_phenotype0.92783230
111MP0000350_abnormal_cell_proliferation0.92398721
112MP0009840_abnormal_foam_cell0.91492598
113MP0002234_abnormal_pharynx_morphology0.91356263
114MP0003119_abnormal_digestive_system0.90752635
115MP0010094_abnormal_chromosome_stability0.90582128
116MP0002098_abnormal_vibrissa_morphology0.90516733
117MP0009053_abnormal_anal_canal0.90513850
118MP0006054_spinal_hemorrhage0.89079441
119MP0005670_abnormal_white_adipose0.88930407
120MP0008004_abnormal_stomach_pH0.87130600
121MP0002932_abnormal_joint_morphology0.87005392
122MP0004130_abnormal_muscle_cell0.86046596
123MP0001614_abnormal_blood_vessel0.85940124
124MP0010386_abnormal_urinary_bladder0.85074693
125MP0008057_abnormal_DNA_replication0.84437990
126MP0002332_abnormal_exercise_endurance0.84408348
127MP0005197_abnormal_uvea_morphology0.83061848
128MP0002933_joint_inflammation0.82636252
129MP0002080_prenatal_lethality0.81603161
130MP0005508_abnormal_skeleton_morphology0.81405759
131MP0004782_abnormal_surfactant_physiolog0.80818954
132MP0003935_abnormal_craniofacial_develop0.78644663
133MP0000537_abnormal_urethra_morphology0.77937427
134MP0003283_abnormal_digestive_organ0.77924760
135MP0003091_abnormal_cell_migration0.77564493
136MP0002108_abnormal_muscle_morphology0.76613018
137MP0000432_abnormal_head_morphology0.76388717
138MP0005165_increased_susceptibility_to0.76064770
139MP0008932_abnormal_embryonic_tissue0.74404069
140MP0001293_anophthalmia0.73436184
141MP0000858_altered_metastatic_potential0.73263590
142MP0004264_abnormal_extraembryonic_tissu0.71315350
143MP0000163_abnormal_cartilage_morphology0.68963024
144MP0002282_abnormal_trachea_morphology0.67915463
145MP0002138_abnormal_hepatobiliary_system0.67722150
146MP0003453_abnormal_keratinocyte_physiol0.67699246
147MP0003937_abnormal_limbs/digits/tail_de0.65563343
148MP0005390_skeleton_phenotype0.65308572
149MP0002168_other_aberrant_phenotype0.63901497
150MP0001915_intracranial_hemorrhage0.62840130
151MP0000428_abnormal_craniofacial_morphol0.61591529
152MP0000230_abnormal_systemic_arterial0.61256193
153MP0003300_gastrointestinal_ulcer0.61132262
154MP0001348_abnormal_lacrimal_gland0.58513289
155MP0000377_abnormal_hair_follicle0.57684797
156MP0002877_abnormal_melanocyte_morpholog0.56812534
157MP0002115_abnormal_skeleton_extremities0.56792970
158MP0004019_abnormal_vitamin_homeostasis0.56408561
159MP0005193_abnormal_anterior_eye0.55957676
160MP0002697_abnormal_eye_size0.55879440

Predicted human phenotypes

RankGene SetZ-score
1Ventricular tachycardia (HP:0004756)6.33656626
2Sudden death (HP:0001699)5.99470004
3Right ventricular cardiomyopathy (HP:0011663)5.62045580
4Atrial fibrillation (HP:0005110)4.70889615
5Muscle fiber splitting (HP:0003555)4.41858189
6Primary atrial arrhythmia (HP:0001692)4.38640393
7Lipoatrophy (HP:0100578)4.33066503
8Supraventricular tachycardia (HP:0004755)4.23781379
9Supraventricular arrhythmia (HP:0005115)4.22025745
10Fragile skin (HP:0001030)4.20086270
11Vascular tortuosity (HP:0004948)4.16540950
12Increased connective tissue (HP:0009025)4.16144163
13Arterial tortuosity (HP:0005116)4.01978917
14Follicular hyperkeratosis (HP:0007502)3.86098747
15Soft skin (HP:0000977)3.78891828
16Exercise-induced muscle cramps (HP:0003710)3.52052907
17Fragile nails (HP:0001808)3.51961053
18Abnormality of the calf musculature (HP:0001430)3.49516397
19Milia (HP:0001056)3.42243268
20Calf muscle hypertrophy (HP:0008981)3.41886590
21Syncope (HP:0001279)3.39832106
22Dilated cardiomyopathy (HP:0001644)3.39183892
23Hyporeflexia of lower limbs (HP:0002600)3.36208476
24Abnormality of the left ventricular outflow tract (HP:0011103)3.35098762
25Subaortic stenosis (HP:0001682)3.35098762
26Abnormality of dentin (HP:0010299)3.30677598
27Palpitations (HP:0001962)3.17246835
28Distal lower limb muscle weakness (HP:0009053)3.16842307
29Neonatal short-limb short stature (HP:0008921)3.11170585
30Bundle branch block (HP:0011710)3.06341640
31Ependymoma (HP:0002888)3.01668784
32Ventricular arrhythmia (HP:0004308)3.00531013
33Plantar hyperkeratosis (HP:0007556)2.88624735
34Blue sclerae (HP:0000592)2.88504528
35Difficulty climbing stairs (HP:0003551)2.84213259
36Asymmetric septal hypertrophy (HP:0001670)2.83694954
37Genu recurvatum (HP:0002816)2.82988238
38Onycholysis (HP:0001806)2.81443581
39Muscle hypertrophy of the lower extremities (HP:0008968)2.80151360
40Wormian bones (HP:0002645)2.73747747
41Prolonged QT interval (HP:0001657)2.72624546
42Mitral valve prolapse (HP:0001634)2.65328108
43Protrusio acetabuli (HP:0003179)2.64806355
44EMG: myopathic abnormalities (HP:0003458)2.63108416
45Abnormal atrioventricular conduction (HP:0005150)2.61355555
46Natal tooth (HP:0000695)2.61316198
47Heart block (HP:0012722)2.57619988
48Cerebral aneurysm (HP:0004944)2.56810632
49Hypoplastic ischia (HP:0003175)2.54065257
50Atrioventricular block (HP:0001678)2.52250716
51Premature rupture of membranes (HP:0001788)2.52000345
52Peritonitis (HP:0002586)2.47801766
53Type 1 muscle fiber predominance (HP:0003803)2.42306739
54Hydroxyprolinuria (HP:0003080)2.41201572
55Abnormality of proline metabolism (HP:0010907)2.41201572
56Thick nail (HP:0001805)2.40464879
57Ankle contracture (HP:0006466)2.39915398
58Selective tooth agenesis (HP:0001592)2.39731004
59Myoglobinuria (HP:0002913)2.37042191
60Pterygium (HP:0001059)2.36019389
61Abnormality of nail color (HP:0100643)2.33451982
62Rhabdomyolysis (HP:0003201)2.26591550
63Exercise-induced myalgia (HP:0003738)2.25973971
64Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.25849203
65Shallow orbits (HP:0000586)2.25834050
66Coronal craniosynostosis (HP:0004440)2.25555916
67Aortic regurgitation (HP:0001659)2.23863216
68Dilatation of the ascending aorta (HP:0005111)2.23504785
69Ectopia lentis (HP:0001083)2.23353950
70Cardiovascular calcification (HP:0011915)2.23227329
71Abnormality of glutamine family amino acid metabolism (HP:0010902)2.22252164
72Bowel diverticulosis (HP:0005222)2.22027898
73Pulmonary artery stenosis (HP:0004415)2.21731074
74Joint laxity (HP:0001388)2.21357768
75Short nail (HP:0001799)2.20007869
76Palmoplantar keratoderma (HP:0000982)2.19157553
77Rectal prolapse (HP:0002035)2.18775113
78Hyperextensible skin (HP:0000974)2.18561122
79Aortic valve stenosis (HP:0001650)2.18014261
80Nonimmune hydrops fetalis (HP:0001790)2.17082284
81Spondylolisthesis (HP:0003302)2.16243763
82Abnormality of the acetabulum (HP:0003170)2.12111885
83Abnormality of the ischium (HP:0003174)2.11767897
84Astrocytoma (HP:0009592)2.11126253
85Abnormality of the astrocytes (HP:0100707)2.11126253
86Lymphangioma (HP:0100764)2.10351854
87Testicular atrophy (HP:0000029)2.10209770
88Palmoplantar hyperkeratosis (HP:0000972)2.10178658
89Ventricular fibrillation (HP:0001663)2.10086315
90Overgrowth (HP:0001548)2.09071202
91Limited hip movement (HP:0008800)2.08826565
92Thin bony cortex (HP:0002753)2.07515448
93Short humerus (HP:0005792)2.07086453
94Aplasia/hypoplasia of the humerus (HP:0006507)2.06919636
95Increased corneal curvature (HP:0100692)2.06658336
96Keratoconus (HP:0000563)2.06658336
97Broad metatarsal (HP:0001783)2.05857434
98Hypoventilation (HP:0002791)2.04024811
99Nail dystrophy (HP:0008404)2.03591033
100Difficulty running (HP:0009046)2.02780655
101Abnormal delivery (HP:0001787)2.01425570
102Distal lower limb amyotrophy (HP:0008944)2.00125470
103Wide anterior fontanel (HP:0000260)1.97902293
104Aneurysm (HP:0002617)1.97347576
105Mildly elevated creatine phosphokinase (HP:0008180)1.96019745
106Palmar hyperkeratosis (HP:0010765)1.94842942
107Disproportionate tall stature (HP:0001519)1.93373806
108Joint stiffness (HP:0001387)1.90982837
109Aortic aneurysm (HP:0004942)1.89155151
110Hip contracture (HP:0003273)1.87754110
111Abnormality of the 4th metacarpal (HP:0010012)1.87716311
112Coxa vara (HP:0002812)1.85284189
113Multiple enchondromatosis (HP:0005701)1.85033133
114Limb-girdle muscle atrophy (HP:0003797)1.84962070
115Areflexia of lower limbs (HP:0002522)1.84858143
116Wrist flexion contracture (HP:0001239)1.84675767
117Elbow flexion contracture (HP:0002987)1.84315540
118Alopecia of scalp (HP:0002293)1.83736001
119Mesangial abnormality (HP:0001966)1.83728300
120Atrophic scars (HP:0001075)1.82651091
121Abnormality of the salivary glands (HP:0010286)1.81888509
122Bowed forearm bones (HP:0003956)1.81467693
123Bowing of the arm (HP:0006488)1.81467693
124Malnutrition (HP:0004395)1.80055800
125Ulnar bowing (HP:0003031)1.80034008
126Preauricular pit (HP:0004467)1.79738347
127Periauricular skin pits (HP:0100277)1.79738347
128Trismus (HP:0000211)1.79625535
129Slender build (HP:0001533)1.79507805
130Myotonia (HP:0002486)1.76781578
131Tibial bowing (HP:0002982)1.76116620
132Round ear (HP:0100830)1.75300556
133Abnormal EKG (HP:0003115)1.75252726
134Advanced eruption of teeth (HP:0006288)1.74690643
135Abnormality of carpal bone ossification (HP:0006257)1.74567443
136Bradycardia (HP:0001662)1.73180723
137Flat acetabular roof (HP:0003180)1.71902385
138Bladder diverticulum (HP:0000015)1.71021625
139Scapular winging (HP:0003691)1.70709265
140Shawl scrotum (HP:0000049)1.69865280
141Skin pits (HP:0100276)1.68988532
142Upper limb amyotrophy (HP:0009129)1.68970649
143Distal upper limb amyotrophy (HP:0007149)1.68970649
144Mitral regurgitation (HP:0001653)1.68851748
145Glioma (HP:0009733)1.68410466
146Vascular calcification (HP:0004934)1.68382592
147Spinal rigidity (HP:0003306)1.68179862
148Biliary tract neoplasm (HP:0100574)1.67644831
149Fused cervical vertebrae (HP:0002949)1.66349194
150Left ventricular hypertrophy (HP:0001712)1.66001705
151Urethral obstruction (HP:0000796)1.65436603
152Muscle fibrillation (HP:0010546)1.65333105
153Cervical subluxation (HP:0003308)1.64402539
154Ovoid vertebral bodies (HP:0003300)1.64359983
155Inguinal hernia (HP:0000023)1.63270327
156Adenoma sebaceum (HP:0009720)1.63041130
157Angiofibromas (HP:0010615)1.63041130
158Radial bowing (HP:0002986)1.62701986
159Hematochezia (HP:0002573)1.62186574
160Protruding ear (HP:0000411)1.62152732
161Neoplasm of the rectum (HP:0100743)1.61564651
162Abnormal hair laboratory examination (HP:0003328)1.61201310
163Abnormality of the anterior chamber (HP:0000593)1.60436022
164Hydroureter (HP:0000072)1.59103164
165Congenital glaucoma (HP:0001087)1.58786623
166Vertebral clefting (HP:0008428)1.58576741
167Aortic dissection (HP:0002647)1.58457527
168Uterine neoplasm (HP:0010784)1.57885033
169Short 4th metacarpal (HP:0010044)1.56635281
170Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.56635281
171Abnormality of the pubic bones (HP:0003172)1.53030253
172Skull defect (HP:0001362)1.52945725
173Muscular dystrophy (HP:0003560)1.52074121
174Neonatal death (HP:0003811)1.51512378
175Abnormality of the tricuspid valve (HP:0001702)1.50825558
176Agnosia (HP:0010524)1.50811881
177Short hallux (HP:0010109)1.50764330
178Aplasia/Hypoplasia of the hallux (HP:0008362)1.50763155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.07608053
2EPHA23.77039618
3MYLK2.92677841
4CDK122.84058066
5MST1R2.77301650
6PKN22.76609601
7NTRK12.68069647
8LMTK22.67145870
9NEK12.34110311
10STK38L2.33910287
11DMPK2.22645502
12LATS11.95297272
13TRIB31.86370475
14DDR21.85886568
15PDGFRA1.82591378
16PDK31.82053705
17PDK41.82053705
18LATS21.75848971
19LIMK11.73396277
20PDK21.68611545
21RIPK11.64470495
22TIE11.60631223
23PAK41.59001515
24PIK3CA1.46598159
25ZAK1.45699433
26PHKG21.40567641
27PHKG11.40567641
28TTK1.40237859
29STK41.40226401
30NME21.34273653
31PTK2B1.32799836
32EPHB11.30753545
33AKT31.25040721
34OBSCN1.23539199
35RPS6KB21.22512951
36GRK11.22242099
37KDR1.14142940
38ERBB41.11263087
39PRKD21.11091093
40EPHB21.10661247
41ICK1.09547559
42TRPM71.09443775
43FLT31.08931899
44PIK3CG1.05919636
45CDK71.05743169
46RPS6KA21.05508267
47MAPKAPK31.03938915
48TGFBR11.02583576
49WEE11.00972480
50STK241.00246322
51FRK0.98838639
52CDC42BPA0.98222344
53WNK40.97110813
54NEK20.95877020
55MTOR0.95867876
56PAK30.93288242
57ADRBK10.91591958
58TGFBR20.91478228
59MET0.90118714
60MAP3K30.89997039
61PDGFRB0.89446382
62STK30.89306214
63BRD40.88664834
64FER0.86510675
65RPS6KA40.83614938
66ACVR1B0.83224019
67PRKCE0.82893749
68BUB10.81454410
69RPS6KC10.79768458
70RPS6KL10.79768458
71ROCK20.79066691
72MAP3K120.78544107
73BMX0.78277826
74BCKDK0.77398011
75ADRBK20.76442666
76AURKB0.75959172
77DAPK30.75298711
78PLK10.75124002
79ILK0.73942108
80PTK60.73740399
81PRKD10.71689049
82ABL20.68451885
83ROCK10.68378496
84RPS6KA60.67361205
85PAK20.66614931
86FGFR40.65818505
87MATK0.65218682
88TAOK20.62198400
89MAP3K80.61177185
90MAP3K100.60992472
91PRKG20.60636908
92STK100.60573083
93PTK20.60460032
94STK380.60209825
95MAP3K50.56951016
96BMPR1B0.56695768
97STK390.56330636
98CAMK1D0.54090786
99CDK60.53640415
100ALK0.53600473
101MAP3K60.53455016
102SIK10.53428984
103CDK40.52330773
104ERBB30.52100981
105CAMK40.51920929
106AKT20.51799423
107CHEK20.51046461
108TESK10.50026694
109EPHA30.49424274
110CDK80.49219969
111PIM10.49063803
112FGFR10.48244594
113SRC0.44386796
114ERN10.43209687
115PRKAA10.42368232
116MAP3K70.41630196
117CDC70.41074396
118MUSK0.40848466
119RPS6KA10.40535489
120CAMK2D0.40369699
121GSK3A0.40232351
122MARK30.39961143
123PIM20.39589347
124CHEK10.39341079
125ATR0.38783326
126MAP2K20.38442012
127PRKCI0.38370756
128MAP2K10.38370738
129NEK90.37953283
130MAP3K110.37783977
131MAPKAPK50.36827458
132SMG10.35663196
133ARAF0.35596599
134MAPK70.34870125
135FGFR20.32990353
136ERBB20.29354617
137IGF1R0.29069555
138PRKAA20.28780985
139INSR0.28414514
140CAMK2G0.23833425
141INSRR0.18856819
142PAK10.17485713
143PRKCD0.16793392
144EEF2K0.15483216

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.62056778
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.36852298
3Dilated cardiomyopathy_Homo sapiens_hsa054143.22056736
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.04585463
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.72546303
6Sulfur metabolism_Homo sapiens_hsa009202.70226996
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.42211750
8Cardiac muscle contraction_Homo sapiens_hsa042602.26436796
9Viral myocarditis_Homo sapiens_hsa054162.24108569
10Adherens junction_Homo sapiens_hsa045202.16092746
11Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.05616506
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.05017464
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.97412407
14Mismatch repair_Homo sapiens_hsa034301.94064549
15Fat digestion and absorption_Homo sapiens_hsa049751.81050170
16ECM-receptor interaction_Homo sapiens_hsa045121.75601108
17RNA transport_Homo sapiens_hsa030131.70477316
18Focal adhesion_Homo sapiens_hsa045101.68026338
19DNA replication_Homo sapiens_hsa030301.66312377
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62086975
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.60532720
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.57713212
23Carbon metabolism_Homo sapiens_hsa012001.56349994
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55494505
25Hippo signaling pathway_Homo sapiens_hsa043901.52334829
26Base excision repair_Homo sapiens_hsa034101.49710475
27Small cell lung cancer_Homo sapiens_hsa052221.49122076
28Vitamin digestion and absorption_Homo sapiens_hsa049771.48776195
29Notch signaling pathway_Homo sapiens_hsa043301.46162952
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45685607
31Tight junction_Homo sapiens_hsa045301.40476545
32Renin-angiotensin system_Homo sapiens_hsa046141.39931920
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37910161
34Cell cycle_Homo sapiens_hsa041101.37700721
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.36850632
36p53 signaling pathway_Homo sapiens_hsa041151.36274210
37Axon guidance_Homo sapiens_hsa043601.36108402
38HIF-1 signaling pathway_Homo sapiens_hsa040661.35597354
39Spliceosome_Homo sapiens_hsa030401.34738013
40MicroRNAs in cancer_Homo sapiens_hsa052061.32071610
41Basal cell carcinoma_Homo sapiens_hsa052171.30717247
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.30655226
43Proteoglycans in cancer_Homo sapiens_hsa052051.26049218
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.24610676
45Selenocompound metabolism_Homo sapiens_hsa004501.23286541
46TGF-beta signaling pathway_Homo sapiens_hsa043501.22742290
47One carbon pool by folate_Homo sapiens_hsa006701.15426620
48Linoleic acid metabolism_Homo sapiens_hsa005911.13806259
49Galactose metabolism_Homo sapiens_hsa000521.13243309
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.12003235
51Sulfur relay system_Homo sapiens_hsa041221.10844104
52Bladder cancer_Homo sapiens_hsa052191.09789474
53Lysine degradation_Homo sapiens_hsa003101.09070870
54Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.08186996
55Parkinsons disease_Homo sapiens_hsa050121.07118749
56Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06461342
57RNA polymerase_Homo sapiens_hsa030201.04296230
58Nucleotide excision repair_Homo sapiens_hsa034201.02806106
59Ether lipid metabolism_Homo sapiens_hsa005651.01279343
60Huntingtons disease_Homo sapiens_hsa050161.00967959
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.00639063
62Fatty acid degradation_Homo sapiens_hsa000710.99033527
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.96672978
64Arginine biosynthesis_Homo sapiens_hsa002200.96293038
65Homologous recombination_Homo sapiens_hsa034400.95374754
66Amoebiasis_Homo sapiens_hsa051460.94118036
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.94015725
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.93530284
69Biosynthesis of amino acids_Homo sapiens_hsa012300.89538185
70mRNA surveillance pathway_Homo sapiens_hsa030150.88965588
71Caffeine metabolism_Homo sapiens_hsa002320.88632838
72Retinol metabolism_Homo sapiens_hsa008300.88124638
73Oxidative phosphorylation_Homo sapiens_hsa001900.87941562
74Arachidonic acid metabolism_Homo sapiens_hsa005900.87553092
75Central carbon metabolism in cancer_Homo sapiens_hsa052300.87467589
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.86550193
77Pathways in cancer_Homo sapiens_hsa052000.85848253
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84284889
79HTLV-I infection_Homo sapiens_hsa051660.83494448
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83095909
81Melanoma_Homo sapiens_hsa052180.82910564
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80592422
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80363178
84PPAR signaling pathway_Homo sapiens_hsa033200.80235723
85Propanoate metabolism_Homo sapiens_hsa006400.79807271
86Sphingolipid metabolism_Homo sapiens_hsa006000.79509661
87Fructose and mannose metabolism_Homo sapiens_hsa000510.78797317
88Hedgehog signaling pathway_Homo sapiens_hsa043400.78650253
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.78635355
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.78118758
91Glycerolipid metabolism_Homo sapiens_hsa005610.77632868
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77623981
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76346441
94Starch and sucrose metabolism_Homo sapiens_hsa005000.75601485
95Histidine metabolism_Homo sapiens_hsa003400.75252843
96Maturity onset diabetes of the young_Homo sapiens_hsa049500.73856850
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73550021
98N-Glycan biosynthesis_Homo sapiens_hsa005100.71603202
99Chronic myeloid leukemia_Homo sapiens_hsa052200.71310104
100Bile secretion_Homo sapiens_hsa049760.70429119
101Thyroid cancer_Homo sapiens_hsa052160.70339359
102Apoptosis_Homo sapiens_hsa042100.68217811
103Complement and coagulation cascades_Homo sapiens_hsa046100.67163332
104Chemical carcinogenesis_Homo sapiens_hsa052040.67131448
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67046186
106mTOR signaling pathway_Homo sapiens_hsa041500.66838649
107Viral carcinogenesis_Homo sapiens_hsa052030.65815388
108RNA degradation_Homo sapiens_hsa030180.64883167
109Insulin resistance_Homo sapiens_hsa049310.64431322
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64142675
111Legionellosis_Homo sapiens_hsa051340.63350301
112Melanogenesis_Homo sapiens_hsa049160.61798068
113Fanconi anemia pathway_Homo sapiens_hsa034600.61460901
114Thyroid hormone synthesis_Homo sapiens_hsa049180.61305908
115Proteasome_Homo sapiens_hsa030500.60534942
116Toxoplasmosis_Homo sapiens_hsa051450.59338208
117Pancreatic secretion_Homo sapiens_hsa049720.59097190
118Epstein-Barr virus infection_Homo sapiens_hsa051690.56676684
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.56234281
120Arginine and proline metabolism_Homo sapiens_hsa003300.55475038
121Vibrio cholerae infection_Homo sapiens_hsa051100.54072403
122Alzheimers disease_Homo sapiens_hsa050100.53822169
123Glutathione metabolism_Homo sapiens_hsa004800.52968357
124Endometrial cancer_Homo sapiens_hsa052130.52894099
125Prostate cancer_Homo sapiens_hsa052150.51785201
126Ribosome_Homo sapiens_hsa030100.51590781
127Renal cell carcinoma_Homo sapiens_hsa052110.51259473
128Fatty acid metabolism_Homo sapiens_hsa012120.51098509
129Tryptophan metabolism_Homo sapiens_hsa003800.51092999
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50489252
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50233567
132AMPK signaling pathway_Homo sapiens_hsa041520.49043252
133Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49020141
134Herpes simplex infection_Homo sapiens_hsa051680.48267506
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46539686
136Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46190633
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45467983
138Insulin signaling pathway_Homo sapiens_hsa049100.45362557
139Pyrimidine metabolism_Homo sapiens_hsa002400.45157524
140Rap1 signaling pathway_Homo sapiens_hsa040150.44794693
141Protein digestion and absorption_Homo sapiens_hsa049740.44736694
142Renin secretion_Homo sapiens_hsa049240.44696682
143Salmonella infection_Homo sapiens_hsa051320.44158918
144Colorectal cancer_Homo sapiens_hsa052100.43432925
145Dorso-ventral axis formation_Homo sapiens_hsa043200.42824210
146Acute myeloid leukemia_Homo sapiens_hsa052210.42239894
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41979910
148Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41867534
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41742109
150Wnt signaling pathway_Homo sapiens_hsa043100.41351501
151Ovarian steroidogenesis_Homo sapiens_hsa049130.41189120
152Gap junction_Homo sapiens_hsa045400.40688234
153Nitrogen metabolism_Homo sapiens_hsa009100.40200813
154Ras signaling pathway_Homo sapiens_hsa040140.40075600
155Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37919597
156Shigellosis_Homo sapiens_hsa051310.37615011
157Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36315020
158Other glycan degradation_Homo sapiens_hsa005110.35730511
159Phototransduction_Homo sapiens_hsa047440.33522472
160Insulin secretion_Homo sapiens_hsa049110.31897152
161Mineral absorption_Homo sapiens_hsa049780.31304990
162Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31252522
163Endocytosis_Homo sapiens_hsa041440.30012580

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