FBLN7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratan sulfate catabolic process (GO:0042340)8.19405714
2cartilage development involved in endochondral bone morphogenesis (GO:0060351)6.55541872
3collagen fibril organization (GO:0030199)6.09408644
4chondrocyte development (GO:0002063)5.88589408
5protein K11-linked deubiquitination (GO:0035871)5.44291900
6negative regulation of smooth muscle cell differentiation (GO:0051151)5.41793667
7cell aggregation (GO:0098743)5.31666870
8cartilage condensation (GO:0001502)5.31666870
9protein heterotrimerization (GO:0070208)5.31254283
10detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.89911035
11regulation of acrosome reaction (GO:0060046)4.78506591
12positive regulation of extracellular matrix organization (GO:1903055)4.50539614
13tolerance induction (GO:0002507)4.38077064
14negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.30674721
15negative regulation of T-helper cell differentiation (GO:0045623)4.30674721
16collagen catabolic process (GO:0030574)4.27026932
17collagen metabolic process (GO:0032963)4.25653733
18notochord development (GO:0030903)4.07882558
19bone trabecula formation (GO:0060346)4.06631907
20multicellular organismal macromolecule metabolic process (GO:0044259)4.03391302
21limb bud formation (GO:0060174)3.98192170
22multicellular organismal catabolic process (GO:0044243)3.97672896
23nephron epithelium morphogenesis (GO:0072088)3.97537793
24nephron tubule morphogenesis (GO:0072078)3.97537793
25peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.92036910
26multicellular organismal metabolic process (GO:0044236)3.85334626
27tooth mineralization (GO:0034505)3.76629621
28regulation of G0 to G1 transition (GO:0070316)3.75194601
29negative regulation of alpha-beta T cell differentiation (GO:0046639)3.74857106
30chondroitin sulfate biosynthetic process (GO:0030206)3.72142193
31dendritic spine morphogenesis (GO:0060997)3.68812241
32negative regulation of anoikis (GO:2000811)3.68197393
33endothelial cell morphogenesis (GO:0001886)3.67311271
34dermatan sulfate biosynthetic process (GO:0030208)3.67155016
35piRNA metabolic process (GO:0034587)3.67129285
36multicellular organism reproduction (GO:0032504)3.64674062
37regulation of plasminogen activation (GO:0010755)3.64440421
38negative regulation of myotube differentiation (GO:0010832)3.61012102
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.59369870
40endodermal cell differentiation (GO:0035987)3.56926184
41response to pheromone (GO:0019236)3.56168112
42detection of chemical stimulus involved in sensory perception (GO:0050907)3.54120365
43extracellular matrix disassembly (GO:0022617)3.53762877
44retinal cone cell development (GO:0046549)3.48331807
45regulation of extracellular matrix disassembly (GO:0010715)3.46155977
46cellular ketone body metabolic process (GO:0046950)3.46025526
47protein retention in ER lumen (GO:0006621)3.44885197
48dermatan sulfate metabolic process (GO:0030205)3.44655424
49behavioral response to nicotine (GO:0035095)3.42145027
50peptidyl-proline hydroxylation (GO:0019511)3.41094439
51glomerular basement membrane development (GO:0032836)3.39888855
52negative regulation of cytosolic calcium ion concentration (GO:0051481)3.39568129
53embryonic skeletal joint morphogenesis (GO:0060272)3.39525334
54sulfur compound catabolic process (GO:0044273)3.37748275
55cellular response to ATP (GO:0071318)3.37135971
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.36564618
57positive regulation of cartilage development (GO:0061036)3.35699207
58chondrocyte proliferation (GO:0035988)3.32763461
59chemosensory behavior (GO:0007635)3.31274349
60blood vessel maturation (GO:0001955)3.30640239
61positive regulation of chondrocyte differentiation (GO:0032332)3.30524631
62extracellular fibril organization (GO:0043206)3.28427298
63keratan sulfate biosynthetic process (GO:0018146)3.26464318
64reflex (GO:0060004)3.24620150
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23951887
66keratan sulfate metabolic process (GO:0042339)3.22702380
67neural tube formation (GO:0001841)3.22124401
68cartilage development (GO:0051216)3.21903260
69seminiferous tubule development (GO:0072520)3.20787500
70detection of light stimulus involved in sensory perception (GO:0050962)3.20188102
71detection of light stimulus involved in visual perception (GO:0050908)3.20188102
72negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.19985487
73regulation of female gonad development (GO:2000194)3.19770752
74DNA methylation involved in gamete generation (GO:0043046)3.19653022
75extracellular matrix organization (GO:0030198)3.11267730
76ketone body metabolic process (GO:1902224)3.10404562
77extracellular structure organization (GO:0043062)3.10264112
78positive regulation of fatty acid oxidation (GO:0046321)3.08087774
79regulation of anoikis (GO:2000209)3.07537725
80myelination in peripheral nervous system (GO:0022011)3.07323324
81peripheral nervous system axon ensheathment (GO:0032292)3.07323324
82neuron projection extension involved in neuron projection guidance (GO:1902284)3.07077852
83axon extension involved in axon guidance (GO:0048846)3.07077852
84cornea development in camera-type eye (GO:0061303)3.06445041
85positive regulation of male gonad development (GO:2000020)3.06299167
86phosphatidylinositol acyl-chain remodeling (GO:0036149)3.04954305
87proteoglycan metabolic process (GO:0006029)3.02641383
88regulation of isotype switching to IgG isotypes (GO:0048302)3.01510456
89regulation of transforming growth factor beta2 production (GO:0032909)3.01260706
90renal tubule morphogenesis (GO:0061333)3.00708849
91regulation of calcium ion-dependent exocytosis (GO:0017158)3.00311106
92iron ion import (GO:0097286)2.99498671
93negative regulation of chondrocyte differentiation (GO:0032331)2.99053176
94short-term memory (GO:0007614)2.97793807
95regulation of smooth muscle cell differentiation (GO:0051150)2.97429475
96positive regulation of gastrulation (GO:2000543)2.97009745
97regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.96066733
98bone morphogenesis (GO:0060349)2.95810618
99replacement ossification (GO:0036075)2.95794770
100endochondral ossification (GO:0001958)2.95794770
101negative regulation of gluconeogenesis (GO:0045721)2.94448194
102glycosaminoglycan catabolic process (GO:0006027)2.94433060
103UDP-N-acetylglucosamine metabolic process (GO:0006047)2.94077384
104gamma-aminobutyric acid transport (GO:0015812)2.93323640
105negative regulation of muscle cell differentiation (GO:0051148)2.91107310
106chondrocyte differentiation (GO:0002062)2.90839673
107regulation of male gonad development (GO:2000018)2.90226053
108extracellular matrix assembly (GO:0085029)2.89835919
109nucleotide-sugar biosynthetic process (GO:0009226)2.89422097
110basement membrane organization (GO:0071711)2.83108705
111regulation of extracellular matrix organization (GO:1903053)2.82443508
112glycerophospholipid catabolic process (GO:0046475)2.82404133
113positive regulation of mitochondrial fission (GO:0090141)2.81034609
114chondroitin sulfate catabolic process (GO:0030207)2.80977869
115negative regulation of cartilage development (GO:0061037)2.80214332
116positive regulation of membrane potential (GO:0045838)2.79996666
117glycosaminoglycan biosynthetic process (GO:0006024)2.77045469
118hippo signaling (GO:0035329)2.75896866
119glomerular visceral epithelial cell development (GO:0072015)2.75768386
120aminoglycan catabolic process (GO:0006026)2.75565280
121righting reflex (GO:0060013)2.75386591
122negative regulation of astrocyte differentiation (GO:0048712)2.75141511
123endocardial cushion morphogenesis (GO:0003203)2.74712203
124L-fucose catabolic process (GO:0042355)2.74048513
125fucose catabolic process (GO:0019317)2.74048513
126L-fucose metabolic process (GO:0042354)2.74048513
127regulation of timing of cell differentiation (GO:0048505)2.73705164
128glomerular epithelial cell development (GO:0072310)2.73347486
129auditory receptor cell stereocilium organization (GO:0060088)2.72859813
130vascular endothelial growth factor signaling pathway (GO:0038084)2.72832658
131aminoglycan biosynthetic process (GO:0006023)2.72558859
132cellular response to BMP stimulus (GO:0071773)2.71963173
133response to BMP (GO:0071772)2.71963173
134SMAD protein signal transduction (GO:0060395)2.71808743
135protein hydroxylation (GO:0018126)2.71332791
136gap junction assembly (GO:0016264)2.71147743
137positive regulation of osteoblast proliferation (GO:0033690)2.70925676
138regulation of neurotransmitter uptake (GO:0051580)2.70783628
139phosphatidylserine acyl-chain remodeling (GO:0036150)2.70025135
140skin morphogenesis (GO:0043589)2.69686796
141regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69496784
142regulation of chondrocyte differentiation (GO:0032330)2.68828841
143water-soluble vitamin biosynthetic process (GO:0042364)2.68228997
144positive regulation of p38MAPK cascade (GO:1900745)2.67299860
145cAMP catabolic process (GO:0006198)2.66672859
146positive regulation of glycogen biosynthetic process (GO:0045725)2.66101407
147epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64944345
148ossification (GO:0001503)2.63815327
149heart valve morphogenesis (GO:0003179)2.63778442
150skeletal system development (GO:0001501)2.63738163
151kidney morphogenesis (GO:0060993)2.63655643
152skeletal muscle organ development (GO:0060538)2.60574531
153regulation of cartilage development (GO:0061035)2.59931147
154diaphragm development (GO:0060539)2.58544464
155lung epithelium development (GO:0060428)2.57311828
156regulation of macrophage chemotaxis (GO:0010758)2.56830532
157inner ear receptor stereocilium organization (GO:0060122)2.56780595
158detection of chemical stimulus (GO:0009593)2.55869167
159behavioral response to ethanol (GO:0048149)2.55568602
160positive regulation of defense response to virus by host (GO:0002230)2.52043214
161cAMP metabolic process (GO:0046058)2.50368251
162positive regulation of humoral immune response (GO:0002922)2.50031726
163phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.49633811
164cAMP biosynthetic process (GO:0006171)2.48630350
165oxidative demethylation (GO:0070989)2.47035842
166cilium or flagellum-dependent cell motility (GO:0001539)2.46191431
167drug catabolic process (GO:0042737)2.46082665
168cilium morphogenesis (GO:0060271)2.45417952
169arachidonic acid secretion (GO:0050482)2.45109008
170icosanoid secretion (GO:0032309)2.45109008
171embryonic digestive tract morphogenesis (GO:0048557)2.43135417
172positive regulation of protein sumoylation (GO:0033235)2.42950259
173pyrimidine nucleobase catabolic process (GO:0006208)2.42104349
174regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42067067
175synaptic transmission, dopaminergic (GO:0001963)2.41287430
176potassium ion transmembrane transport (GO:0071805)2.41191686
177cellular potassium ion transport (GO:0071804)2.41191686
178positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.40052104
179regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.38499847
180response to gravity (GO:0009629)2.37989316
181thyroid hormone metabolic process (GO:0042403)2.37934498
182phosphorelay signal transduction system (GO:0000160)2.37611270
183cyclic nucleotide catabolic process (GO:0009214)2.37486053
184positive regulation of meiosis (GO:0045836)2.36460710
185transmission of nerve impulse (GO:0019226)2.36015695
186photoreceptor cell development (GO:0042461)2.35515717
187hindbrain development (GO:0030902)2.35301536
188dentate gyrus development (GO:0021542)2.35230349
189positive regulation of T cell differentiation in thymus (GO:0033089)2.33711586
190positive regulation of uterine smooth muscle contraction (GO:0070474)2.33104263
191protein localization to synapse (GO:0035418)2.32769966
192negative regulation of cAMP-mediated signaling (GO:0043951)2.32586127
193rhodopsin mediated signaling pathway (GO:0016056)2.32420428
194alpha-beta T cell differentiation (GO:0046632)2.32155138
195regulation of T-helper 1 cell differentiation (GO:0045625)2.31894494
196neuron fate determination (GO:0048664)2.31176101
197regulation of hippo signaling (GO:0035330)2.30826425
198regulation of cAMP-mediated signaling (GO:0043949)2.30552533
199adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway (GO:0007193)2.30065898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human5.92915897
2EZH2_22144423_ChIP-Seq_EOC_Human5.25351312
3AR_21572438_ChIP-Seq_LNCaP_Human3.41887694
4VDR_22108803_ChIP-Seq_LS180_Human2.98042526
5RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.79250108
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.76803813
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72957702
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68990248
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.50232971
10ZNF274_21170338_ChIP-Seq_K562_Hela2.40473132
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31234680
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.31169840
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.29688621
14ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25033612
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22256276
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.20147176
17CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17788270
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16843566
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.11910849
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.09410426
21CJUN_26792858_Chip-Seq_BT549_Human2.03749229
22IGF1R_20145208_ChIP-Seq_DFB_Human2.02966252
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.01449774
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00178911
25RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00178911
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97003519
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.94822897
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.93383882
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.91432503
30CLOCK_20551151_ChIP-Seq_293T_Human1.87264164
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86648906
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85354710
33CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80782782
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.80270926
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.79506378
36EZH2_27304074_Chip-Seq_ESCs_Mouse1.75363096
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73954220
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.72535263
39P300_19829295_ChIP-Seq_ESCs_Human1.68392338
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.68246019
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.66963250
42TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.66931079
43TP53_16413492_ChIP-PET_HCT116_Human1.66926934
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.66575536
45DROSHA_22980978_ChIP-Seq_HELA_Human1.65222026
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.64432240
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.61918157
48REST_21632747_ChIP-Seq_MESCs_Mouse1.61105997
49SALL4_18804426_ChIP-ChIP_XEN_Mouse1.61021483
50* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56309008
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.54311695
52STAT3_23295773_ChIP-Seq_U87_Human1.51184143
53ER_23166858_ChIP-Seq_MCF-7_Human1.51002641
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.50879963
55AR_25329375_ChIP-Seq_VCAP_Human1.50239438
56TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49543260
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49543260
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.49252564
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.49252564
60PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48547251
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.45454853
62TP53_18474530_ChIP-ChIP_U2OS_Human1.45153788
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44537035
64EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41160450
65* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41113281
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.39885009
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39671265
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38679898
69CBP_20019798_ChIP-Seq_JUKART_Human1.38679898
70EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37315553
71SOX2_20726797_ChIP-Seq_SW620_Human1.36642137
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.35718148
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34301684
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33548231
75BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.33075390
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32883175
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.32075208
78RNF2_27304074_Chip-Seq_NSC_Mouse1.31771775
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.31729717
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.31427281
81TCF4_23295773_ChIP-Seq_U87_Human1.30254898
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29365719
83SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29325284
84FUS_26573619_Chip-Seq_HEK293_Human1.28917981
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.28754152
86PRDM14_20953172_ChIP-Seq_ESCs_Human1.27986844
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26692471
88NANOG_18555785_Chip-Seq_ESCs_Mouse1.26562621
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25492799
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25008488
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.24980269
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.24900346
93* EZH2_27294783_Chip-Seq_ESCs_Mouse1.24336381
94TCF4_22108803_ChIP-Seq_LS180_Human1.24247598
95AHR_22903824_ChIP-Seq_MCF-7_Human1.23752423
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21035863
97EWS_26573619_Chip-Seq_HEK293_Human1.20008224
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19713781
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19427606
100SMAD4_21741376_ChIP-Seq_EPCs_Human1.19422279
101TAF15_26573619_Chip-Seq_HEK293_Human1.17582120
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16535123
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.15682017
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14813978
105BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13392515
106NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12641823
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.12616341
108CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11353562
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10803117
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.10803117
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10399613
112RUNX2_22187159_ChIP-Seq_PCA_Human1.10040119
113CDX2_20551321_ChIP-Seq_CACO-2_Human1.09587376
114P53_22387025_ChIP-Seq_ESCs_Mouse1.08795893
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.08644731
116SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06847957
117* BRD4_25478319_ChIP-Seq_HGPS_Human1.06743739
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.06367361
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06338706
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.05187731
121RXR_22108803_ChIP-Seq_LS180_Human1.05013764
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.04889432
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04677462
124TP53_22573176_ChIP-Seq_HFKS_Human1.03687465
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03663304
126JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03280767
127WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02664659
128GATA2_21666600_ChIP-Seq_HMVEC_Human1.01867238
129FOXO3_23340844_ChIP-Seq_DLD1_Human1.00912123
130ISL1_27105846_Chip-Seq_CPCs_Mouse1.00509224
131BCAT_22108803_ChIP-Seq_LS180_Human1.00360711
132LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99821183
133GBX2_23144817_ChIP-Seq_PC3_Human0.99802407
134ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99077942
135SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95545115
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95517769
137TP63_23658742_ChIP-Seq_EP156T_Human0.95501522
138KDM2B_26808549_Chip-Seq_K562_Human0.95500408
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.95379425
140EGR1_19032775_ChIP-ChIP_M12_Human0.94282225
141SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93499308
142SMAD4_21799915_ChIP-Seq_A2780_Human0.91521545
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91151545
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90740830
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.89759913
146TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89711092
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88280163
148NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.86860469
149TBX20_22080862_ChIP-Seq_HEART_Mouse0.85325489
150TBX20_22328084_ChIP-Seq_HEART_Mouse0.85325489
151ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84621787
152VDR_24787735_ChIP-Seq_THP-1_Human0.82351760
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.82163234
154TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.80749816
155RING1B_27294783_Chip-Seq_NPCs_Mouse0.80164714
156OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.80141528
157BMI1_23680149_ChIP-Seq_NPCS_Mouse0.79580873
158SMC1_22415368_ChIP-Seq_MEFs_Mouse0.78031448
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.77561363

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology7.07303122
2MP0008438_abnormal_cutaneous_collagen6.65469035
3MP0005275_abnormal_skin_tensile5.09558221
4MP0005084_abnormal_gallbladder_morpholo4.45563253
5MP0003195_calcinosis3.86708726
6MP0004272_abnormal_basement_membrane3.62552852
7MP0002933_joint_inflammation3.24700254
8MP0002282_abnormal_trachea_morphology3.07293402
9MP0006292_abnormal_olfactory_placode3.01336278
10MP0004134_abnormal_chest_morphology2.94051550
11MP0009384_cardiac_valve_regurgitation2.73254414
12MP0003252_abnormal_bile_duct2.64172867
13MP0005508_abnormal_skeleton_morphology2.60139586
14MP0002928_abnormal_bile_duct2.59657091
15MP0006054_spinal_hemorrhage2.53321714
16MP0002138_abnormal_hepatobiliary_system2.52293511
17MP0008961_abnormal_basal_metabolism2.50974592
18MP0000163_abnormal_cartilage_morphology2.48677722
19MP0008877_abnormal_DNA_methylation2.45916906
20MP0009250_abnormal_appendicular_skeleto2.43790638
21MP0005623_abnormal_meninges_morphology2.42879152
22MP0001958_emphysema2.37866020
23MP0006072_abnormal_retinal_apoptosis2.37586038
24MP0001501_abnormal_sleep_pattern2.35205821
25MP0002108_abnormal_muscle_morphology2.33855533
26MP0003279_aneurysm2.24573071
27MP0003880_abnormal_central_pattern2.18009567
28MP0003705_abnormal_hypodermis_morpholog2.13830756
29MP0002896_abnormal_bone_mineralization2.09282407
30MP0005551_abnormal_eye_electrophysiolog2.06937990
31MP0002102_abnormal_ear_morphology2.01199342
32MP0002115_abnormal_skeleton_extremities1.99645501
33MP0002876_abnormal_thyroid_physiology1.94650894
34MP0001502_abnormal_circadian_rhythm1.91479211
35MP0004133_heterotaxia1.90485752
36MP0009745_abnormal_behavioral_response1.85731029
37MP0003878_abnormal_ear_physiology1.85646314
38MP0005377_hearing/vestibular/ear_phenot1.85646314
39MP0002638_abnormal_pupillary_reflex1.80134417
40MP0002272_abnormal_nervous_system1.79382614
41MP0000751_myopathy1.74554739
42MP0001299_abnormal_eye_distance/1.73424171
43MP0002113_abnormal_skeleton_development1.70435591
44MP0008872_abnormal_physiological_respon1.70304540
45MP0003718_maternal_effect1.66851437
46MP0005390_skeleton_phenotype1.66033727
47MP0003646_muscle_fatigue1.61454920
48MP0001968_abnormal_touch/_nociception1.59844258
49MP0001984_abnormal_olfaction1.59614195
50MP0008789_abnormal_olfactory_epithelium1.57858461
51MP0005257_abnormal_intraocular_pressure1.56881616
52MP0002060_abnormal_skin_morphology1.55241739
53MP0003566_abnormal_cell_adhesion1.54168628
54MP0003122_maternal_imprinting1.53953225
55MP0002089_abnormal_postnatal_growth/wei1.53232031
56MP0002249_abnormal_larynx_morphology1.51282416
57MP0000013_abnormal_adipose_tissue1.50724649
58MP0006276_abnormal_autonomic_nervous1.49132416
59MP0000762_abnormal_tongue_morphology1.45940864
60MP0003385_abnormal_body_wall1.45053766
61MP0000569_abnormal_digit_pigmentation1.44671718
62MP0002572_abnormal_emotion/affect_behav1.44666541
63MP0002295_abnormal_pulmonary_circulatio1.43412571
64MP0005646_abnormal_pituitary_gland1.41763751
65MP0005379_endocrine/exocrine_gland_phen1.40148151
66MP0004142_abnormal_muscle_tone1.39567273
67MP0001542_abnormal_bone_strength1.38908775
68MP0001348_abnormal_lacrimal_gland1.38885941
69MP0004742_abnormal_vestibular_system1.33936838
70MP0008875_abnormal_xenobiotic_pharmacok1.32050006
71MP0005023_abnormal_wound_healing1.32019574
72MP0003123_paternal_imprinting1.29736512
73MP0002163_abnormal_gland_morphology1.29563910
74MP0002064_seizures1.29355594
75MP0005645_abnormal_hypothalamus_physiol1.28308297
76MP0002109_abnormal_limb_morphology1.24303768
77MP0003787_abnormal_imprinting1.23486266
78MP0003942_abnormal_urinary_system1.22566575
79MP0001873_stomach_inflammation1.22355347
80MP0005253_abnormal_eye_physiology1.21483486
81MP0003635_abnormal_synaptic_transmissio1.21268983
82MP0002063_abnormal_learning/memory/cond1.21267718
83MP0009780_abnormal_chondrocyte_physiolo1.20458023
84MP0009046_muscle_twitch1.20164190
85MP0002938_white_spotting1.18287572
86MP0002557_abnormal_social/conspecific_i1.17616921
87MP0002837_dystrophic_cardiac_calcinosis1.17556510
88MP0001661_extended_life_span1.16999459
89MP0001485_abnormal_pinna_reflex1.16063373
90MP0000049_abnormal_middle_ear1.13976831
91MP0002116_abnormal_craniofacial_bone1.13700394
92MP0001944_abnormal_pancreas_morphology1.13418297
93MP0003755_abnormal_palate_morphology1.11333548
94MP0001486_abnormal_startle_reflex1.10946517
95MP0005394_taste/olfaction_phenotype1.09890164
96MP0005499_abnormal_olfactory_system1.09890164
97MP0000534_abnormal_ureter_morphology1.09820315
98MP0001533_abnormal_skeleton_physiology1.08842882
99MP0002736_abnormal_nociception_after1.08102133
100MP0004130_abnormal_muscle_cell1.08097777
101MP0003091_abnormal_cell_migration1.06776688
102MP0005164_abnormal_response_to1.06150718
103MP0005448_abnormal_energy_balance1.05224562
104MP0005171_absent_coat_pigmentation1.04636700
105MP0003795_abnormal_bone_structure1.03766121
106MP0000631_abnormal_neuroendocrine_gland1.02686372
107MP0008775_abnormal_heart_ventricle1.01617261
108MP0001905_abnormal_dopamine_level1.00307375
109MP0002693_abnormal_pancreas_physiology1.00203655
110MP0004859_abnormal_synaptic_plasticity0.99909112
111MP0003879_abnormal_hair_cell0.98163677
112MP0005389_reproductive_system_phenotype0.97523976
113MP0000343_altered_response_to0.97268041
114MP0001270_distended_abdomen0.95630562
115MP0000749_muscle_degeneration0.95547188
116MP0005395_other_phenotype0.95239106
117MP0000372_irregular_coat_pigmentation0.95045796
118MP0005195_abnormal_posterior_eye0.94437812
119MP0000428_abnormal_craniofacial_morphol0.94179642
120MP0003937_abnormal_limbs/digits/tail_de0.93571230
121MP0002233_abnormal_nose_morphology0.93500894
122MP0001986_abnormal_taste_sensitivity0.93463240
123MP0001919_abnormal_reproductive_system0.92702590
124MP0005076_abnormal_cell_differentiation0.92109458
125MP0002932_abnormal_joint_morphology0.90484128
126MP0000432_abnormal_head_morphology0.90400870
127MP0003950_abnormal_plasma_membrane0.88068293
128MP0002998_abnormal_bone_remodeling0.87842009
129MP0008569_lethality_at_weaning0.87049327
130MP0004043_abnormal_pH_regulation0.86754105
131MP0001963_abnormal_hearing_physiology0.86342000
132MP0000733_abnormal_muscle_development0.85599369
133MP0002160_abnormal_reproductive_system0.84810950
134MP0002067_abnormal_sensory_capabilities0.82252221
135MP0001970_abnormal_pain_threshold0.81493317
136MP0005187_abnormal_penis_morphology0.81297416
137MP0002139_abnormal_hepatobiliary_system0.80702811
138MP0004197_abnormal_fetal_growth/weight/0.79898120
139MP0004885_abnormal_endolymph0.79564005
140MP0002735_abnormal_chemical_nociception0.79466845
141MP0005369_muscle_phenotype0.78834401
142MP0001243_abnormal_dermal_layer0.78728912
143MP0000778_abnormal_nervous_system0.78350745
144MP0002751_abnormal_autonomic_nervous0.78058094
145MP0002277_abnormal_respiratory_mucosa0.77739330
146MP0004484_altered_response_of0.77159862
147MP0000026_abnormal_inner_ear0.76958220
148MP0002111_abnormal_tail_morphology0.76453130
149MP0005360_urolithiasis0.76302306
150MP0001177_atelectasis0.76153871
151MP0002184_abnormal_innervation0.75915254
152MP0002114_abnormal_axial_skeleton0.75795439
153MP0000747_muscle_weakness0.75778347
154MP0005670_abnormal_white_adipose0.75406498
155MP0005410_abnormal_fertilization0.75242908
156MP0003121_genomic_imprinting0.73333685
157MP0005595_abnormal_vascular_smooth0.73178053
158MP0005174_abnormal_tail_pigmentation0.73047227
159MP0003115_abnormal_respiratory_system0.72767077
160MP0000230_abnormal_systemic_arterial0.71504435
161MP0004264_abnormal_extraembryonic_tissu0.70831687
162MP0005423_abnormal_somatic_nervous0.70672650
163MP0003935_abnormal_craniofacial_develop0.70484799
164MP0008004_abnormal_stomach_pH0.68041839
165MP0002128_abnormal_blood_circulation0.67345414
166MP0000750_abnormal_muscle_regeneration0.67203887
167MP0006138_congestive_heart_failure0.65486582
168MP0004883_abnormal_blood_vessel0.64855040
169MP0002796_impaired_skin_barrier0.64232995
170MP0000003_abnormal_adipose_tissue0.64203533
171MP0003011_delayed_dark_adaptation0.64122633
172MP0010030_abnormal_orbit_morphology0.62898186
173MP0000767_abnormal_smooth_muscle0.60941662
174MP0002133_abnormal_respiratory_system0.56687863
175MP0005388_respiratory_system_phenotype0.56687863
176MP0002909_abnormal_adrenal_gland0.55477872
177MP0000647_abnormal_sebaceous_gland0.53920220
178MP0005193_abnormal_anterior_eye0.53086951
179MP0010368_abnormal_lymphatic_system0.52225801
180MP0004084_abnormal_cardiac_muscle0.51573558
181MP0005197_abnormal_uvea_morphology0.50905154
182MP0004087_abnormal_muscle_fiber0.49400883
183MP0000537_abnormal_urethra_morphology0.48904636
184MP0010771_integument_phenotype0.48894756
185MP0005248_abnormal_Harderian_gland0.48752093

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.05769370
2Irregular epiphyses (HP:0010582)6.72594503
3Vitreoretinal degeneration (HP:0000655)5.97589235
4Hypoplastic ischia (HP:0003175)5.36647090
5Cupped ribs (HP:0000887)5.28081411
6Small epiphyses (HP:0010585)5.06518797
7Cervical subluxation (HP:0003308)5.00730684
8Abnormality of the ischium (HP:0003174)4.87485120
9Neonatal short-limb short stature (HP:0008921)4.69818161
10Delayed epiphyseal ossification (HP:0002663)4.63006522
11Molar tooth sign on MRI (HP:0002419)4.53802632
12Abnormality of midbrain morphology (HP:0002418)4.53802632
13Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.50316007
14Abnormal tarsal ossification (HP:0008369)4.44249437
15Protrusio acetabuli (HP:0003179)3.98546925
16Stomatitis (HP:0010280)3.93646870
17Nephronophthisis (HP:0000090)3.85022873
18Flat acetabular roof (HP:0003180)3.83737715
19Congenital stationary night blindness (HP:0007642)3.83181211
20Flat capital femoral epiphysis (HP:0003370)3.79177760
21Premature rupture of membranes (HP:0001788)3.74905319
22Aplasia/Hypoplasia of the fovea (HP:0008060)3.74803792
23Hypoplasia of the fovea (HP:0007750)3.74803792
24Osteoarthritis (HP:0002758)3.71997632
25Polyuria (HP:0000103)3.67436501
26Genu varum (HP:0002970)3.60118229
27Mild short stature (HP:0003502)3.48216886
28Pancreatic cysts (HP:0001737)3.46861398
29Abnormality of the renal medulla (HP:0100957)3.45412467
30Metaphyseal cupping (HP:0003021)3.35603746
31Pancreatic fibrosis (HP:0100732)3.34020981
32Protuberant abdomen (HP:0001538)3.22048917
33Abnormality of the fovea (HP:0000493)3.19138901
34Type II lissencephaly (HP:0007260)3.17555750
35Abnormal vertebral ossification (HP:0100569)3.15541901
36Abnormal foot bone ossification (HP:0010675)3.15494563
37Abnormal drinking behavior (HP:0030082)2.99394457
38Polydipsia (HP:0001959)2.99394457
39Abnormal urine output (HP:0012590)2.98906435
40Thyroiditis (HP:0100646)2.98383194
41Abnormality of femoral epiphyses (HP:0006499)2.97334251
42Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.97334251
43Absent epiphyses (HP:0010577)2.95584820
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.95584820
45Ovoid vertebral bodies (HP:0003300)2.88402483
46Abnormality of calcium-phosphate metabolism (HP:0100530)2.86859572
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.85271155
48Flattened epiphyses (HP:0003071)2.85214341
49Limited hip movement (HP:0008800)2.83845926
50Hip contracture (HP:0003273)2.83456050
51Progressive cerebellar ataxia (HP:0002073)2.81260226
52True hermaphroditism (HP:0010459)2.81249529
53Attenuation of retinal blood vessels (HP:0007843)2.80752179
54Tubular atrophy (HP:0000092)2.77336671
55Arthropathy (HP:0003040)2.76325298
56Cystic liver disease (HP:0006706)2.75319362
57Platyspondyly (HP:0000926)2.73574817
58Metaphyseal irregularity (HP:0003025)2.73241975
59Broad metatarsal (HP:0001783)2.73238032
60Ankle contracture (HP:0006466)2.71790737
61Abnormality of the proximal phalanges of the hand (HP:0009834)2.71713957
62Abnormality of carpal bone ossification (HP:0006257)2.70690331
63Hypoplasia of the odontoid process (HP:0003311)2.70160093
64Abnormality of the vertebral endplates (HP:0005106)2.67802779
65Oligodactyly (hands) (HP:0001180)2.67218632
66Thin ribs (HP:0000883)2.65621474
67Coxa vara (HP:0002812)2.65093786
68IgG deficiency (HP:0004315)2.64541501
69Short femoral neck (HP:0100864)2.60658710
70Beaking of vertebral bodies (HP:0004568)2.60135624
71Muscle fiber splitting (HP:0003555)2.59755769
72Congenital sensorineural hearing impairment (HP:0008527)2.59190133
73Gaze-evoked nystagmus (HP:0000640)2.58639128
74Abnormality of the renal cortex (HP:0011035)2.57909179
75Anterior segment dysgenesis (HP:0007700)2.56544600
76Metaphyseal dysplasia (HP:0100255)2.55411697
77Follicular hyperkeratosis (HP:0007502)2.55251058
78Optic nerve hypoplasia (HP:0000609)2.54377023
79Fibular hypoplasia (HP:0003038)2.54150261
80Enlarged epiphyses (HP:0010580)2.53087054
81Spinal cord compression (HP:0002176)2.51836055
82Abnormality of renal excretion (HP:0011036)2.51031834
83Shallow orbits (HP:0000586)2.49214379
84Large for gestational age (HP:0001520)2.47472039
85Abnormality of the epiphysis of the femoral head (HP:0010574)2.47451833
86Febrile seizures (HP:0002373)2.46497305
87Chronic hepatic failure (HP:0100626)2.46357403
88Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.41872322
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.40935897
90Hemiparesis (HP:0001269)2.38515941
91Ulnar deviation of the wrist (HP:0003049)2.37877661
92Inability to walk (HP:0002540)2.37502011
93Abnormality of the pubic bones (HP:0003172)2.34871425
94Mesomelia (HP:0003027)2.33609880
95Vertebral clefting (HP:0008428)2.33360107
96Aplasia/Hypoplasia of the tongue (HP:0010295)2.32484297
97Supernumerary spleens (HP:0009799)2.32322979
98Irregular vertebral endplates (HP:0003301)2.32014145
99Abnormality of the femoral head (HP:0003368)2.31357835
100Type 1 muscle fiber predominance (HP:0003803)2.31225402
101Increased corneal curvature (HP:0100692)2.31065262
102Keratoconus (HP:0000563)2.31065262
103Medial flaring of the eyebrow (HP:0010747)2.29118288
104Absent frontal sinuses (HP:0002688)2.26127777
105Severe combined immunodeficiency (HP:0004430)2.25235001
106Abnormality of the odontoid process (HP:0003310)2.22818737
107Exostoses (HP:0100777)2.21577805
108Increased connective tissue (HP:0009025)2.20893901
109Abnormality of the acetabulum (HP:0003170)2.20414349
110Thoracolumbar scoliosis (HP:0002944)2.18970047
111Waddling gait (HP:0002515)2.18528808
112Hypomagnesemia (HP:0002917)2.18062413
113Aplasia/Hypoplasia of the macula (HP:0008059)2.17699475
114Aplasia/hypoplasia of the femur (HP:0005613)2.17475455
115Abnormal hand bone ossification (HP:0010660)2.17284722
116Abnormality of the middle phalanges of the toes (HP:0010183)2.16209260
117Hyperventilation (HP:0002883)2.16004096
118Bony spicule pigmentary retinopathy (HP:0007737)2.14502189
119Disproportionate short-trunk short stature (HP:0003521)2.14501546
120Fair hair (HP:0002286)2.13854009
121Vertebral hypoplasia (HP:0008417)2.13428764
122Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.13428764
123Abnormal ossification of hand bones (HP:0005921)2.12416047
124Abnormality of dental color (HP:0011073)2.11825015
125Abnormality of incisor morphology (HP:0011063)2.10753137
126Lumbar hyperlordosis (HP:0002938)2.10205974
127Vertebral compression fractures (HP:0002953)2.09371884
128Blue sclerae (HP:0000592)2.09330369
129Stillbirth (HP:0003826)2.09067163
130Broad-based gait (HP:0002136)2.09029757
131Radial bowing (HP:0002986)2.08368202
132Aplasia/Hypoplasia affecting the retina (HP:0008061)2.05636763
133Amelogenesis imperfecta (HP:0000705)2.04308794
134Bell-shaped thorax (HP:0001591)2.04086400
135Right ventricular cardiomyopathy (HP:0011663)2.02872881
136Congenital hepatic fibrosis (HP:0002612)2.02539604
137Micromelia (HP:0002983)2.01715544
138Spinal rigidity (HP:0003306)1.99053400
139Pendular nystagmus (HP:0012043)1.98849657
140Alopecia of scalp (HP:0002293)1.98145269
141Barrel-shaped chest (HP:0001552)1.98051644
142Soft skin (HP:0000977)1.97294846
143Wrist flexion contracture (HP:0001239)1.96465555
144Aortic dissection (HP:0002647)1.95995716
145Retinal dysplasia (HP:0007973)1.94104713
146Abnormal rod and cone electroretinograms (HP:0008323)1.94104676
147Oligodactyly (HP:0012165)1.93429510
148Joint stiffness (HP:0001387)1.93409661
149Abnormality of renal resorption (HP:0011038)1.93052098
150Overgrowth (HP:0001548)1.92287927
151Focal seizures (HP:0007359)1.90708316
152Sprengel anomaly (HP:0000912)1.88734439
153Abnormality of the 2nd finger (HP:0004100)1.88610713
154Abnormality of dentin (HP:0010299)1.88390582
155Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.88062427
156Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.88024617
157Genu recurvatum (HP:0002816)1.87410009
158Ulnar bowing (HP:0003031)1.87395996
159Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.87360507
160Narrow forehead (HP:0000341)1.87102531
161Rhizomelia (HP:0008905)1.86749399
162Intestinal atresia (HP:0011100)1.86163243
163Hypothermia (HP:0002045)1.85231573
164Abolished electroretinogram (ERG) (HP:0000550)1.85052066
165Focal motor seizures (HP:0011153)1.84764741
166Wide anterior fontanel (HP:0000260)1.84667417
167Small hand (HP:0200055)1.83131502
168Genetic anticipation (HP:0003743)1.82917583
169Abdominal situs inversus (HP:0003363)1.82163162
170Abnormality of abdominal situs (HP:0011620)1.82163162
171Striae distensae (HP:0001065)1.81738877
172Hypoproteinemia (HP:0003075)1.81659540
173Stage 5 chronic kidney disease (HP:0003774)1.81544376
174Cerebellar dysplasia (HP:0007033)1.80019286
175Abnormality of the labia minora (HP:0012880)1.79486865
176Severe muscular hypotonia (HP:0006829)1.79343896
177Elevated erythrocyte sedimentation rate (HP:0003565)1.78939571
178Congenital, generalized hypertrichosis (HP:0004540)1.78462477
179Postaxial foot polydactyly (HP:0001830)1.75597119
180Abnormality of the pons (HP:0007361)1.75331985
181Hypoplasia of the ulna (HP:0003022)1.73919437
182Highly arched eyebrow (HP:0002553)1.73782276
183Sclerocornea (HP:0000647)1.73152878
184Postaxial hand polydactyly (HP:0001162)1.72124702
1853-Methylglutaconic aciduria (HP:0003535)1.70329278
186Generalized hypopigmentation of hair (HP:0011358)1.70282957
187Tubulointerstitial fibrosis (HP:0005576)1.70110651
188Tachypnea (HP:0002789)1.69980081
189Abnormality of B cell number (HP:0010975)1.69195936
190Hypoplasia of the pons (HP:0012110)1.68287773
191Shawl scrotum (HP:0000049)1.68205922
192Decreased central vision (HP:0007663)1.66711862
193Abnormal biliary tract physiology (HP:0012439)1.64665790
194Bile duct proliferation (HP:0001408)1.64665790
195Aplasia/Hypoplasia of the ulna (HP:0006495)1.64598495
196Conical tooth (HP:0000698)1.64243439
197Duplicated collecting system (HP:0000081)1.62742036
198Ectopic kidney (HP:0000086)1.62406281
199Methylmalonic acidemia (HP:0002912)1.62179451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.26914871
2NTRK25.14747045
3FRK4.84275909
4MAP3K34.14054762
5STK38L3.59155478
6MST43.24927880
7ADRBK22.81512601
8TXK2.80072973
9PDGFRA2.71041157
10STK242.71014841
11TRIB32.52689574
12NME12.43101731
13GRK12.42841760
14LATS12.38614860
15EPHB22.34087275
16PRKG22.29359365
17EPHA42.10458313
18TRPM72.04360184
19MAP3K92.01633817
20MAP4K21.92499411
21NLK1.90085683
22TAOK31.85444381
23ERBB31.85432983
24FER1.85312832
25INSRR1.77280922
26PAK61.74460722
27WNK41.73837459
28STK31.70115135
29SIK11.69011956
30EPHB11.67630832
31TIE11.66548327
32CAMKK11.59831926
33MAPK131.57843481
34LATS21.56961881
35PINK11.56657276
36FGFR21.51433587
37EPHA31.50036048
38ROCK11.50011655
39PTK61.43337527
40TLK11.42483835
41CAMKK21.30751607
42ITK1.29163660
43PASK1.24479197
44GSK3A1.23879737
45TEC1.22494581
46MAP3K131.21722453
47MAPK151.21243354
48PAK31.18281917
49PRKCG1.17340352
50PDGFRB1.16452756
51MET1.16395367
52PRKD31.11964503
53AKT31.10185025
54PLK21.07621293
55PTK21.07481272
56AKT21.05095165
57HIPK21.03343626
58ARAF1.03226077
59EIF2AK31.00930173
60MAP2K10.97256023
61ZAK0.96087830
62STK390.95612490
63CAMK10.94391985
64MAP3K40.94269933
65MAPK70.94250187
66MAPK120.93003041
67ROCK20.92912397
68SGK4940.92388162
69SGK2230.92388162
70MAP4K10.91863454
71TNIK0.87450837
72BCR0.85951946
73WNK30.85555851
74TSSK60.85519755
75DYRK1A0.85162718
76BMX0.84492449
77PRKCH0.82212672
78PTK2B0.81879301
79ERN10.78841114
80OXSR10.75334974
81TTN0.75194581
82MAP2K60.74957291
83TGFBR20.74614631
84PDK20.73768909
85PRKCQ0.71693073
86OBSCN0.68915493
87PKN20.68013790
88TGFBR10.67957544
89RET0.67946469
90NEK60.66912885
91ACVR1B0.66878869
92CHUK0.65611068
93WNK10.64205279
94SGK10.63980137
95PAK20.63858930
96LRRK20.62827838
97MARK10.61347711
98IKBKB0.60050705
99MYLK0.59560017
100DYRK20.59545619
101FGFR10.58898348
102PHKG20.57997929
103PHKG10.57997929
104TRIM280.57636498
105CAMK2A0.57141631
106MAPKAPK50.56513713
107MAPKAPK30.55965997
108ADRBK10.55620793
109SIK20.55494231
110LIMK10.53160556
111GRK50.51652047
112PRKCE0.50845043
113MKNK20.49978813
114CDC42BPA0.49036420
115CSK0.48841569
116KSR10.45929407
117FGFR30.45785225
118CSNK1G10.45553284
119TNK20.45535009
120BCKDK0.45339940
121CAMK1D0.44884722
122PIM20.43918964
123INSR0.43890709
124PAK40.43712785
125PRKACA0.42953437
126ERBB40.41372969
127ABL20.40819611
128MAP3K70.39893129
129MAP2K70.39688065
130SRC0.38776764
131MARK30.38527793
132NTRK30.38486303
133LCK0.38014480
134MTOR0.37680930
135MAPK40.36942525
136BRAF0.36735011
137MAPK90.36507338
138PRKCA0.35853706
139PRKAA10.35777542
140MAP3K140.35141705
141UHMK10.35091604
142GRK60.34138383
143CAMK40.33755382
144STK380.33156152
145SGK20.33019799
146SGK30.32663395
147IRAK10.32130745
148STK110.31842700
149PNCK0.31704090
150PRKD10.31358294
151CSNK1D0.31334055
152PRKCI0.31125954
153NUAK10.31059363
154IGF1R0.29339037
155CDK50.29280553
156PRKCZ0.28242069
157PIK3CA0.28152493
158BMPR1B0.27171649
159ABL10.26989581
160NTRK10.26211159
161PRKG10.25344506
162CASK0.24985796
163TYRO30.24684730
164PDPK10.23091604
165DAPK20.22881744
166NEK90.22529454
167PKN10.22269309

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.12415990
2Protein digestion and absorption_Homo sapiens_hsa049744.10923422
3Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.76215874
4Phototransduction_Homo sapiens_hsa047443.05765913
5Linoleic acid metabolism_Homo sapiens_hsa005913.00127028
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.78468492
7Focal adhesion_Homo sapiens_hsa045102.65795126
8Circadian rhythm_Homo sapiens_hsa047102.23016305
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.17653549
10Morphine addiction_Homo sapiens_hsa050322.06306420
11Insulin secretion_Homo sapiens_hsa049112.04279104
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03587179
13Circadian entrainment_Homo sapiens_hsa047131.94839842
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90713011
15TGF-beta signaling pathway_Homo sapiens_hsa043501.88261431
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.87489199
17GABAergic synapse_Homo sapiens_hsa047271.84482871
18Dorso-ventral axis formation_Homo sapiens_hsa043201.84100973
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83147936
20Hippo signaling pathway_Homo sapiens_hsa043901.78532571
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77541703
22Malaria_Homo sapiens_hsa051441.75104923
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.72583013
24Nitrogen metabolism_Homo sapiens_hsa009101.67581026
25Glutamatergic synapse_Homo sapiens_hsa047241.63822112
26Caffeine metabolism_Homo sapiens_hsa002321.62815437
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.62567566
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.61507580
29Nicotine addiction_Homo sapiens_hsa050331.60670813
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.56704892
31Sphingolipid metabolism_Homo sapiens_hsa006001.49468844
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45956745
33Proteoglycans in cancer_Homo sapiens_hsa052051.43171288
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41396388
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38484180
36Taste transduction_Homo sapiens_hsa047421.35309009
37Hedgehog signaling pathway_Homo sapiens_hsa043401.34667916
38Starch and sucrose metabolism_Homo sapiens_hsa005001.34443410
39Dilated cardiomyopathy_Homo sapiens_hsa054141.31782692
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28927881
41Steroid biosynthesis_Homo sapiens_hsa001001.27712134
42Amoebiasis_Homo sapiens_hsa051461.26230485
43Protein export_Homo sapiens_hsa030601.25057511
44Basal cell carcinoma_Homo sapiens_hsa052171.24039808
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23998810
46Primary immunodeficiency_Homo sapiens_hsa053401.22654807
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.21803110
48Vitamin B6 metabolism_Homo sapiens_hsa007501.21599292
49Sulfur metabolism_Homo sapiens_hsa009201.21590427
50Serotonergic synapse_Homo sapiens_hsa047261.19814812
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19269424
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18508514
53Basal transcription factors_Homo sapiens_hsa030221.16498163
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14477473
55Glycosaminoglycan degradation_Homo sapiens_hsa005311.13026007
56Arginine and proline metabolism_Homo sapiens_hsa003301.12977935
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10149297
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10043811
59Other glycan degradation_Homo sapiens_hsa005111.09284797
60RNA degradation_Homo sapiens_hsa030181.08930423
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.07151999
62Calcium signaling pathway_Homo sapiens_hsa040201.06929299
63Sulfur relay system_Homo sapiens_hsa041221.05990713
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02803638
65Amphetamine addiction_Homo sapiens_hsa050311.01835014
66Axon guidance_Homo sapiens_hsa043601.01460791
67Collecting duct acid secretion_Homo sapiens_hsa049661.01050143
68Butanoate metabolism_Homo sapiens_hsa006500.99534251
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96565634
70Ovarian steroidogenesis_Homo sapiens_hsa049130.96123054
71Small cell lung cancer_Homo sapiens_hsa052220.95530873
72Tryptophan metabolism_Homo sapiens_hsa003800.94957720
73Retinol metabolism_Homo sapiens_hsa008300.94430089
74Vitamin digestion and absorption_Homo sapiens_hsa049770.93843996
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90272559
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.87380517
77Phagosome_Homo sapiens_hsa041450.86888557
78Synaptic vesicle cycle_Homo sapiens_hsa047210.85976974
79Ras signaling pathway_Homo sapiens_hsa040140.85298274
80Olfactory transduction_Homo sapiens_hsa047400.84832014
81Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84617495
82Insulin resistance_Homo sapiens_hsa049310.81714062
83T cell receptor signaling pathway_Homo sapiens_hsa046600.80770951
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80699316
85RNA polymerase_Homo sapiens_hsa030200.80450780
86Pancreatic secretion_Homo sapiens_hsa049720.80330307
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80198536
88cAMP signaling pathway_Homo sapiens_hsa040240.78520145
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78339602
90Adherens junction_Homo sapiens_hsa045200.78273292
91Prostate cancer_Homo sapiens_hsa052150.78197130
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76873955
93Peroxisome_Homo sapiens_hsa041460.76116184
94Renal cell carcinoma_Homo sapiens_hsa052110.75765887
95Tight junction_Homo sapiens_hsa045300.75609815
96Dopaminergic synapse_Homo sapiens_hsa047280.75385070
97Homologous recombination_Homo sapiens_hsa034400.75349964
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75245049
99PPAR signaling pathway_Homo sapiens_hsa033200.75018426
100Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73370192
101Rap1 signaling pathway_Homo sapiens_hsa040150.72951944
102ABC transporters_Homo sapiens_hsa020100.72714069
103Thyroid hormone synthesis_Homo sapiens_hsa049180.70545304
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70038624
105Chemical carcinogenesis_Homo sapiens_hsa052040.69965550
106Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69466206
107Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67940314
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66400243
109Fat digestion and absorption_Homo sapiens_hsa049750.65568910
110Pathways in cancer_Homo sapiens_hsa052000.65405891
111Melanoma_Homo sapiens_hsa052180.64973835
112Melanogenesis_Homo sapiens_hsa049160.64722816
113Bladder cancer_Homo sapiens_hsa052190.64075804
114Complement and coagulation cascades_Homo sapiens_hsa046100.63999416
115Gap junction_Homo sapiens_hsa045400.63069760
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.60843869
117Galactose metabolism_Homo sapiens_hsa000520.59746414
118Fanconi anemia pathway_Homo sapiens_hsa034600.59050034
119Cocaine addiction_Homo sapiens_hsa050300.57832066
120Wnt signaling pathway_Homo sapiens_hsa043100.57272873
121Selenocompound metabolism_Homo sapiens_hsa004500.56110234
122Arachidonic acid metabolism_Homo sapiens_hsa005900.55683790
123Mineral absorption_Homo sapiens_hsa049780.55104396
124Bile secretion_Homo sapiens_hsa049760.54919246
125Propanoate metabolism_Homo sapiens_hsa006400.53983972
126Oxidative phosphorylation_Homo sapiens_hsa001900.52253519
127MicroRNAs in cancer_Homo sapiens_hsa052060.52083492
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.51976185
129Long-term depression_Homo sapiens_hsa047300.48403995
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47758395
131Pancreatic cancer_Homo sapiens_hsa052120.47247824
132Lysosome_Homo sapiens_hsa041420.47236607
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.47054378
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.46790451
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46606971
136Estrogen signaling pathway_Homo sapiens_hsa049150.44942215
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44863189
138Gastric acid secretion_Homo sapiens_hsa049710.44142280
139Choline metabolism in cancer_Homo sapiens_hsa052310.42832404
140Rheumatoid arthritis_Homo sapiens_hsa053230.42229578
141Oxytocin signaling pathway_Homo sapiens_hsa049210.41174652
142MAPK signaling pathway_Homo sapiens_hsa040100.40970599
143Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40536685
144Lysine degradation_Homo sapiens_hsa003100.40231834
145Glioma_Homo sapiens_hsa052140.39883230
146TNF signaling pathway_Homo sapiens_hsa046680.39160351
147GnRH signaling pathway_Homo sapiens_hsa049120.39052625
148Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39052461
149Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.38312345
150Cholinergic synapse_Homo sapiens_hsa047250.37674403
151Platelet activation_Homo sapiens_hsa046110.37620015
152Renin-angiotensin system_Homo sapiens_hsa046140.37404889
153Purine metabolism_Homo sapiens_hsa002300.37222295
154Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37168778
155Vascular smooth muscle contraction_Homo sapiens_hsa042700.37147701
156Endocytosis_Homo sapiens_hsa041440.36941468
157Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36893958
158Jak-STAT signaling pathway_Homo sapiens_hsa046300.35707236
159Salivary secretion_Homo sapiens_hsa049700.35274942
160Central carbon metabolism in cancer_Homo sapiens_hsa052300.34976547
161Leukocyte transendothelial migration_Homo sapiens_hsa046700.34563631
162Ether lipid metabolism_Homo sapiens_hsa005650.33792257
163Cysteine and methionine metabolism_Homo sapiens_hsa002700.31746350

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »