FBN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of cardioblast differentiation (GO:0051890)5.75352892
2regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.43783426
3cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.35363782
4negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.27319616
5cell communication by electrical coupling (GO:0010644)5.04005445
6planar cell polarity pathway involved in neural tube closure (GO:0090179)5.02259606
7regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.98921694
8collagen fibril organization (GO:0030199)4.88816208
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.81514753
10negative regulation of hormone biosynthetic process (GO:0032353)4.77465122
11protein heterotrimerization (GO:0070208)4.73089269
12relaxation of cardiac muscle (GO:0055119)4.60301213
13chondrocyte proliferation (GO:0035988)4.54881287
14pericardium development (GO:0060039)4.45220357
15regulation of glucocorticoid metabolic process (GO:0031943)4.45142231
16myofibril assembly (GO:0030239)4.43121480
17hippo signaling (GO:0035329)4.37038573
18regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.34341741
19neuron projection extension involved in neuron projection guidance (GO:1902284)4.32782138
20axon extension involved in axon guidance (GO:0048846)4.32782138
21regulation of cardiac muscle cell differentiation (GO:2000725)4.22707416
22paraxial mesoderm development (GO:0048339)4.21788727
23regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.20585469
24G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.18741233
25regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.16554073
26* bone trabecula formation (GO:0060346)4.16283242
27outer ear morphogenesis (GO:0042473)4.13149008
28negative regulation of hormone metabolic process (GO:0032351)4.08001963
29regulation of the force of heart contraction (GO:0002026)4.07890489
30positive regulation of cardiac muscle cell differentiation (GO:2000727)4.05598404
31metanephric mesenchyme development (GO:0072075)4.05445027
32cell proliferation involved in metanephros development (GO:0072203)4.04897597
33* sequestering of extracellular ligand from receptor (GO:0035581)4.01017837
34insulin-like growth factor receptor signaling pathway (GO:0048009)3.99447783
35lateral sprouting from an epithelium (GO:0060601)3.98712246
36craniofacial suture morphogenesis (GO:0097094)3.95904899
37regulation of relaxation of muscle (GO:1901077)3.91183129
38cardiac muscle cell development (GO:0055013)3.90508575
39kidney mesenchyme development (GO:0072074)3.89357563
40atrioventricular valve morphogenesis (GO:0003181)3.86914523
41mesenchyme morphogenesis (GO:0072132)3.80395722
42positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.78476090
43cardiac cell development (GO:0055006)3.74769761
44polarized epithelial cell differentiation (GO:0030859)3.72864148
45embryonic cranial skeleton morphogenesis (GO:0048701)3.72625201
46positive regulation of cardiac muscle tissue development (GO:0055025)3.69583619
47Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.68225869
48negative regulation of striated muscle cell apoptotic process (GO:0010664)3.65526036
49regulation of establishment of planar polarity (GO:0090175)3.61426121
50mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.60748337
51negative regulation of chondrocyte differentiation (GO:0032331)3.59082163
52endocardial cushion development (GO:0003197)3.57968580
53endocardial cushion morphogenesis (GO:0003203)3.57187030
54cardiac epithelial to mesenchymal transition (GO:0060317)3.56343236
55sarcomere organization (GO:0045214)3.55342922
56cell migration involved in heart development (GO:0060973)3.49948596
57chondrocyte development (GO:0002063)3.49186540
58relaxation of smooth muscle (GO:0044557)3.48003847
59cardiac muscle hypertrophy (GO:0003300)3.47370586
60regulation of heart morphogenesis (GO:2000826)3.47256394
61regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.46591301
62positive regulation of cardiac muscle cell proliferation (GO:0060045)3.45737930
63negative regulation of axon extension involved in axon guidance (GO:0048843)3.44881377
64embryonic heart tube development (GO:0035050)3.44632305
65body morphogenesis (GO:0010171)3.44623430
66negative regulation of embryonic development (GO:0045992)3.44228907
67mesenchymal cell proliferation (GO:0010463)3.40156027
68middle ear morphogenesis (GO:0042474)3.39963877
69cell proliferation involved in kidney development (GO:0072111)3.39680821
70sodium ion export (GO:0071436)3.39540590
71head development (GO:0060322)3.39056702
72convergent extension (GO:0060026)3.38179187
73glycoprotein catabolic process (GO:0006516)3.37426686
74pathway-restricted SMAD protein phosphorylation (GO:0060389)3.37201493
75regulation of non-canonical Wnt signaling pathway (GO:2000050)3.37161014
76cardiac muscle tissue morphogenesis (GO:0055008)3.35835609
77cardiac chamber formation (GO:0003207)3.33550715
78embryonic skeletal joint morphogenesis (GO:0060272)3.31946674
79regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.30419036
80positive regulation of mesenchymal cell proliferation (GO:0002053)3.29531399
81mesenchyme development (GO:0060485)3.29493844
82regulation of cardiac muscle tissue development (GO:0055024)3.29165263
83cochlea morphogenesis (GO:0090103)3.26061855
84negative regulation of DNA repair (GO:0045738)3.25975358
85bundle of His cell to Purkinje myocyte communication (GO:0086069)3.25499226
86positive regulation of osteoblast proliferation (GO:0033690)3.25279565
87striated muscle hypertrophy (GO:0014897)3.25036516
88endodermal cell differentiation (GO:0035987)3.24915132
89desmosome organization (GO:0002934)3.24798337
90proximal/distal pattern formation (GO:0009954)3.24758429
91non-canonical Wnt signaling pathway (GO:0035567)3.23506439
92collagen metabolic process (GO:0032963)3.23481133
93cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.19843612
94hindlimb morphogenesis (GO:0035137)3.19116307
95midgut development (GO:0007494)3.17936130
96regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.17275218
97regulation of mesenchymal cell proliferation (GO:0010464)3.16734549
98heart morphogenesis (GO:0003007)3.16352897
99collagen catabolic process (GO:0030574)3.16249028
100cardiac myofibril assembly (GO:0055003)3.15475163
101adult heart development (GO:0007512)3.15229011
102muscle tissue morphogenesis (GO:0060415)3.14129825
103outflow tract septum morphogenesis (GO:0003148)3.13379346
104extracellular fibril organization (GO:0043206)3.13187583
105relaxation of muscle (GO:0090075)3.13127946
106regulation of steroid hormone biosynthetic process (GO:0090030)3.13098313
107glomerular filtration (GO:0003094)3.12807267
108positive regulation of epithelial to mesenchymal transition (GO:0010718)3.12077348
109cranial suture morphogenesis (GO:0060363)3.11730905
110cell communication involved in cardiac conduction (GO:0086065)3.11573485
111gap junction assembly (GO:0016264)3.10220055
112regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.09132706
113embryonic hindlimb morphogenesis (GO:0035116)3.07107399
114positive regulation of cardiac muscle tissue growth (GO:0055023)3.07039542
115cardiac muscle contraction (GO:0060048)3.06711162
116anatomical structure regression (GO:0060033)3.04612538
117negative regulation of cartilage development (GO:0061037)3.04022749
118mesenchymal-epithelial cell signaling (GO:0060638)3.01543394
119multicellular organismal macromolecule metabolic process (GO:0044259)3.00853512
120regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.00535595
121negative regulation of catenin import into nucleus (GO:0035414)2.99697270
122camera-type eye morphogenesis (GO:0048593)2.98950274
123regulation of cardiac muscle cell apoptotic process (GO:0010665)2.94604629
124actin-myosin filament sliding (GO:0033275)2.93900432
125muscle filament sliding (GO:0030049)2.93900432
126glucocorticoid receptor signaling pathway (GO:0042921)2.93139925
127regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.93112922
128positive regulation of smoothened signaling pathway (GO:0045880)2.93016712
129notochord development (GO:0030903)2.91771673
130negative regulation of fatty acid transport (GO:2000192)2.91133829
131embryonic forelimb morphogenesis (GO:0035115)2.90079545
132negative regulation of axon guidance (GO:1902668)2.89860076
133exocrine pancreas development (GO:0031017)2.89363327
134regulation of transforming growth factor beta2 production (GO:0032909)2.88712363
135actin-mediated cell contraction (GO:0070252)2.87789263
136wound healing, spreading of epidermal cells (GO:0035313)2.87077957
137gastrulation with mouth forming second (GO:0001702)2.86256206
138epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.85872164
139multicellular organismal catabolic process (GO:0044243)2.85857003
140prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.85153718
141glial cell migration (GO:0008347)2.84915606
142adrenergic receptor signaling pathway (GO:0071875)2.82840674
143positive regulation of protein export from nucleus (GO:0046827)2.81600407
144cranial nerve structural organization (GO:0021604)2.81433144
145multicellular organismal metabolic process (GO:0044236)2.80783051
146embryonic digit morphogenesis (GO:0042733)2.80105605
147positive regulation of catenin import into nucleus (GO:0035413)2.79918192
148dorsal/ventral axis specification (GO:0009950)2.79883116
149actomyosin structure organization (GO:0031032)2.77128417
150heart valve morphogenesis (GO:0003179)2.76788954
151negative chemotaxis (GO:0050919)2.75511737
152regulation of catenin import into nucleus (GO:0035412)2.75303759
153ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.74427062
154muscle hypertrophy (GO:0014896)2.74261828
155negative regulation of skeletal muscle tissue development (GO:0048642)2.73617293
156forelimb morphogenesis (GO:0035136)2.72449079
157negative regulation of cardiac muscle tissue development (GO:0055026)2.72171061
158regulation of skeletal muscle contraction (GO:0014819)2.71973886
159atrial septum morphogenesis (GO:0060413)2.71804440
160renal filtration (GO:0097205)2.71564898
161regulation of cartilage development (GO:0061035)2.71294811
162branching involved in ureteric bud morphogenesis (GO:0001658)2.71281310
163embryonic skeletal system morphogenesis (GO:0048704)2.71153301
164mesenchymal cell differentiation (GO:0048762)2.71091902
165organ formation (GO:0048645)2.70703000
166positive regulation of heart growth (GO:0060421)2.70446536
167smooth muscle tissue development (GO:0048745)2.70238152
168negative regulation of striated muscle cell differentiation (GO:0051154)2.70185620
169organ induction (GO:0001759)2.69828295
170regulation of chondrocyte differentiation (GO:0032330)2.69497434
171* appendage morphogenesis (GO:0035107)2.67743393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.43786416
2RBPJ_22232070_ChIP-Seq_NCS_Mouse4.39827607
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.79301358
4WT1_19549856_ChIP-ChIP_CCG9911_Human3.15411658
5* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.85669469
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.75331168
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.71279102
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69357532
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.62485665
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.55541427
11HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.53164162
12* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.41144622
13* EED_16625203_ChIP-ChIP_MESCs_Mouse2.36895875
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33078155
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.26489398
16* ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25467923
17* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20675108
18GBX2_23144817_ChIP-Seq_PC3_Human2.18779113
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.15240224
20* ISL1_27105846_Chip-Seq_CPCs_Mouse2.14525565
21* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.11924762
22* EP300_21415370_ChIP-Seq_HL-1_Mouse2.10423416
23* EZH2_27304074_Chip-Seq_ESCs_Mouse2.10199062
24* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09812412
25* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09812412
26CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.07818336
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.02971321
28E2F7_22180533_ChIP-Seq_HELA_Human1.96751874
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.93557940
30* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.85758525
31* TP53_20018659_ChIP-ChIP_R1E_Mouse1.83634120
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.83343178
33BRD4_25478319_ChIP-Seq_HGPS_Human1.78453886
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.76731784
35FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.70745388
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.70659880
37* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68857813
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.68163689
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67333328
40RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66549942
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.65260941
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.64486222
43* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.61379044
44* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60765317
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.59621412
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59419484
47* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59247512
48* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57008340
49KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51315357
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51265510
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.50624993
52* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49306205
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48267032
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.45621292
55SMAD4_21799915_ChIP-Seq_A2780_Human1.45482925
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.44928150
57AR_21909140_ChIP-Seq_LNCAP_Human1.41768121
58* SMAD3_21741376_ChIP-Seq_HESCs_Human1.40131887
59TP53_18474530_ChIP-ChIP_U2OS_Human1.38741129
60CJUN_26792858_Chip-Seq_BT549_Human1.38427914
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.38263835
62* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34962967
63* TBX20_22328084_ChIP-Seq_HEART_Mouse1.33974690
64* TBX20_22080862_ChIP-Seq_HEART_Mouse1.33974690
65EZH2_22144423_ChIP-Seq_EOC_Human1.33824262
66CLOCK_20551151_ChIP-Seq_293T_Human1.32976678
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.31459707
68TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.30656863
69TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.29800208
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29068712
71* SMAD3_21741376_ChIP-Seq_EPCs_Human1.28464874
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28141419
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27571733
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27422849
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.27316420
76SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25234808
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24550386
78* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24363213
79FUS_26573619_Chip-Seq_HEK293_Human1.23927398
80WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23123404
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22973893
82TAF15_26573619_Chip-Seq_HEK293_Human1.21775029
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.21449717
84TP53_16413492_ChIP-PET_HCT116_Human1.21341778
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.21283293
86* P300_19829295_ChIP-Seq_ESCs_Human1.20831275
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17916206
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17087551
89* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16844677
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.15739404
91* RING1B_27294783_Chip-Seq_ESCs_Mouse1.15174476
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13625237
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.11399615
94NANOG_16153702_ChIP-ChIP_HESCs_Human1.11346316
95* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11104003
96* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10045248
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.09769731
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.09454779
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09405496
100* EWS_26573619_Chip-Seq_HEK293_Human1.07987685
101CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.07527190
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06911884
103NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06768269
104CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06588773
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.06323400
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06059671
107P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05547011
108PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05024652
109* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03867706
110SOX2_16153702_ChIP-ChIP_HESCs_Human1.03798366
111GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03713671
112SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.02709232
113ZNF274_21170338_ChIP-Seq_K562_Hela1.02172831
114* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01651264
115E2F4_17652178_ChIP-ChIP_JURKAT_Human1.01309617
116NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00671128
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00671128
118UBF1/2_26484160_Chip-Seq_HMECs_Human0.99322333
119ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99125661
120BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97606517
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96751323
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.95763391
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94525785
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94310334
125TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93551897
126* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93189601
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93137683
128* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90937229
129* SOX9_26525672_Chip-Seq_HEART_Mouse0.90694799
130* PIAS1_25552417_ChIP-Seq_VCAP_Human0.89621636
131AHR_22903824_ChIP-Seq_MCF-7_Human0.89352411
132SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88684703
133* EZH2_27294783_Chip-Seq_ESCs_Mouse0.88672130

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.40861772
2MP0005503_abnormal_tendon_morphology4.16398581
3MP0003122_maternal_imprinting3.64954851
4MP0004084_abnormal_cardiac_muscle3.61750261
5MP0005275_abnormal_skin_tensile3.28765908
6MP0003950_abnormal_plasma_membrane2.99421099
7MP0003123_paternal_imprinting2.93959332
8MP0010030_abnormal_orbit_morphology2.92145894
9MP0003385_abnormal_body_wall2.89983434
10MP0004272_abnormal_basement_membrane2.89959694
11MP0004510_myositis2.81842789
12MP0003705_abnormal_hypodermis_morpholog2.77221825
13MP0009053_abnormal_anal_canal2.77147539
14MP0009250_abnormal_appendicular_skeleto2.53926343
15MP0000751_myopathy2.53041984
16MP0003121_genomic_imprinting2.40256303
17MP0003942_abnormal_urinary_system2.32718691
18MP0003279_aneurysm2.25802836
19MP0000537_abnormal_urethra_morphology2.23269233
20MP0004215_abnormal_myocardial_fiber2.22562455
21MP0004036_abnormal_muscle_relaxation2.21932712
22MP0003941_abnormal_skin_development2.19090376
23MP0006054_spinal_hemorrhage2.18339129
24MP0009384_cardiac_valve_regurgitation2.08334658
25MP0008775_abnormal_heart_ventricle2.07865826
26MP0000534_abnormal_ureter_morphology2.05709031
27MP0002938_white_spotting1.97327332
28MP0005623_abnormal_meninges_morphology1.96479162
29MP0002249_abnormal_larynx_morphology1.93392381
30MP0000049_abnormal_middle_ear1.93364079
31MP0005508_abnormal_skeleton_morphology1.90779297
32MP0002282_abnormal_trachea_morphology1.84658783
33MP0000428_abnormal_craniofacial_morphol1.82759035
34MP0003115_abnormal_respiratory_system1.81834077
35* MP0003937_abnormal_limbs/digits/tail_de1.79001593
36MP0001958_emphysema1.77062831
37* MP0002932_abnormal_joint_morphology1.76312700
38MP0002127_abnormal_cardiovascular_syste1.75670589
39MP0001661_extended_life_span1.75097374
40MP0003755_abnormal_palate_morphology1.71525642
41MP0003935_abnormal_craniofacial_develop1.60740792
42MP0004134_abnormal_chest_morphology1.60664595
43MP0000733_abnormal_muscle_development1.60207757
44MP0005330_cardiomyopathy1.55078974
45MP0002108_abnormal_muscle_morphology1.54778512
46* MP0004145_abnormal_muscle_electrophysio1.53033025
47MP0003567_abnormal_fetal_cardiomyocyte1.48692215
48MP0000566_synostosis1.47490538
49MP0000749_muscle_degeneration1.47219462
50MP0005257_abnormal_intraocular_pressure1.43833876
51MP0000762_abnormal_tongue_morphology1.42190897
52MP0002233_abnormal_nose_morphology1.42188344
53MP0002116_abnormal_craniofacial_bone1.39507639
54* MP0002109_abnormal_limb_morphology1.36365244
55MP0000432_abnormal_head_morphology1.29915548
56MP0002102_abnormal_ear_morphology1.29557806
57MP0001293_anophthalmia1.29554807
58MP0001299_abnormal_eye_distance/1.28570696
59MP0002972_abnormal_cardiac_muscle1.28194210
60MP0000516_abnormal_urinary_system1.26517293
61MP0005367_renal/urinary_system_phenotyp1.26517293
62MP0005620_abnormal_muscle_contractility1.25725364
63MP0000750_abnormal_muscle_regeneration1.24500973
64MP0005248_abnormal_Harderian_gland1.22779532
65MP0000767_abnormal_smooth_muscle1.21517920
66* MP0002115_abnormal_skeleton_extremities1.21496090
67MP0000163_abnormal_cartilage_morphology1.20281749
68MP0004197_abnormal_fetal_growth/weight/1.19199277
69MP0003091_abnormal_cell_migration1.18729989
70MP0005076_abnormal_cell_differentiation1.17206472
71MP0002114_abnormal_axial_skeleton1.16491550
72MP0003283_abnormal_digestive_organ1.15736077
73MP0002837_dystrophic_cardiac_calcinosis1.15295870
74MP0003119_abnormal_digestive_system1.12110603
75MP0002896_abnormal_bone_mineralization1.11707676
76MP0002111_abnormal_tail_morphology1.11510794
77MP0010368_abnormal_lymphatic_system1.10996929
78MP0000013_abnormal_adipose_tissue1.07811938
79MP0002060_abnormal_skin_morphology1.07204767
80MP0005171_absent_coat_pigmentation1.07023870
81* MP0002113_abnormal_skeleton_development1.02634223
82MP0004233_abnormal_muscle_weight1.01771055
83MP0002697_abnormal_eye_size1.01314932
84* MP0004087_abnormal_muscle_fiber1.00040274
85MP0009703_decreased_birth_body0.99734038
86MP0002177_abnormal_outer_ear0.98897824
87MP0005187_abnormal_penis_morphology0.98012387
88MP0004085_abnormal_heartbeat0.97971766
89MP0002085_abnormal_embryonic_tissue0.97638492
90MP0001340_abnormal_eyelid_morphology0.95468917
91MP0002925_abnormal_cardiovascular_devel0.95182912
92MP0005197_abnormal_uvea_morphology0.94404850
93MP0003938_abnormal_ear_development0.93859015
94MP0002092_abnormal_eye_morphology0.93509037
95MP0002089_abnormal_postnatal_growth/wei0.93479870
96MP0001270_distended_abdomen0.92862359
97MP0005023_abnormal_wound_healing0.92840660
98MP0003137_abnormal_impulse_conducting0.91608597
99MP0002084_abnormal_developmental_patter0.91117805
100MP0003315_abnormal_perineum_morphology0.91003101
101MP0003045_fibrosis0.90631779
102MP0001286_abnormal_eye_development0.88463261
103MP0006138_congestive_heart_failure0.88131016
104MP0000462_abnormal_digestive_system0.87329989
105MP0003566_abnormal_cell_adhesion0.86875706
106MP0001243_abnormal_dermal_layer0.86722251
107MP0001175_abnormal_lung_morphology0.85960289
108MP0005193_abnormal_anterior_eye0.84870588
109MP0001915_intracranial_hemorrhage0.83517466
110MP0003890_abnormal_embryonic-extraembry0.81852890
111MP0010352_gastrointestinal_tract_polyps0.81349384
112MP0001177_atelectasis0.79295400
113MP0010630_abnormal_cardiac_muscle0.77988817
114MP0002168_other_aberrant_phenotype0.77760479
115MP0002128_abnormal_blood_circulation0.77356915
116MP0000266_abnormal_heart_morphology0.77281237
117* MP0005369_muscle_phenotype0.76872490
118MP0009697_abnormal_copulation0.76329356
119MP0002088_abnormal_embryonic_growth/wei0.76191316
120MP0000569_abnormal_digit_pigmentation0.75099866
121MP0002295_abnormal_pulmonary_circulatio0.74620707
122MP0001614_abnormal_blood_vessel0.74189063
123MP0002081_perinatal_lethality0.74125606
124MP0003984_embryonic_growth_retardation0.73529084
125MP0001672_abnormal_embryogenesis/_devel0.73281575
126MP0005380_embryogenesis_phenotype0.73281575
127MP0001849_ear_inflammation0.72989303
128MP0001879_abnormal_lymphatic_vessel0.72719289
129MP0002086_abnormal_extraembryonic_tissu0.70754335
130MP0009672_abnormal_birth_weight0.69966797
131MP0001697_abnormal_embryo_size0.69229121
132MP0003861_abnormal_nervous_system0.67174704

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.94832702
2Short 4th metacarpal (HP:0010044)5.36893459
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)5.36893459
4Premature rupture of membranes (HP:0001788)4.94122149
5Shallow orbits (HP:0000586)4.37596527
6Abnormality of the 4th metacarpal (HP:0010012)4.32748045
7Ventricular tachycardia (HP:0004756)4.31522853
8Right ventricular cardiomyopathy (HP:0011663)3.94171216
9Aortic dissection (HP:0002647)3.77956552
10Ankle contracture (HP:0006466)3.60985928
11Broad metatarsal (HP:0001783)3.52995280
12Bladder diverticulum (HP:0000015)3.43486076
13Vitreoretinal degeneration (HP:0000655)3.39268760
14Soft skin (HP:0000977)3.31732707
15Atrophic scars (HP:0001075)3.26782010
16Renal duplication (HP:0000075)3.16681889
17Abnormality of dentin (HP:0010299)3.11395369
18Bundle branch block (HP:0011710)3.07370453
19Morphological abnormality of the middle ear (HP:0008609)3.01629459
20Spondylolisthesis (HP:0003302)3.00384380
21Neonatal short-limb short stature (HP:0008921)2.95064478
22Hepatoblastoma (HP:0002884)2.94132805
23Asymmetry of the thorax (HP:0001555)2.93629599
24Cerebral aneurysm (HP:0004944)2.85429260
25Type 1 muscle fiber predominance (HP:0003803)2.80550672
26Midline defect of the nose (HP:0004122)2.79282799
27Mesomelia (HP:0003027)2.77592880
28Wide anterior fontanel (HP:0000260)2.76906300
29Fragile skin (HP:0001030)2.74663003
30Follicular hyperkeratosis (HP:0007502)2.71740194
31Sudden death (HP:0001699)2.68257983
32* Mitral valve prolapse (HP:0001634)2.68074567
33Aortic aneurysm (HP:0004942)2.66916759
34Lipoatrophy (HP:0100578)2.65041426
35Peritonitis (HP:0002586)2.59069385
36Cutaneous finger syndactyly (HP:0010554)2.54922369
37Deviation of the hallux (HP:0010051)2.54565591
38Microglossia (HP:0000171)2.52540220
39* Abnormality of the calf musculature (HP:0001430)2.52539232
40Genu recurvatum (HP:0002816)2.47480267
41Buphthalmos (HP:0000557)2.45096960
42Broad toe (HP:0001837)2.43949936
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43248547
44Hallux valgus (HP:0001822)2.42445954
45Blue sclerae (HP:0000592)2.41206327
46Broad long bones (HP:0005622)2.38613392
47Atrial fibrillation (HP:0005110)2.38448643
48Bowel diverticulosis (HP:0005222)2.37831430
49Wrist flexion contracture (HP:0001239)2.37344433
50Spinal cord lesions (HP:0100561)2.34442690
51Syringomyelia (HP:0003396)2.34442690
52Aneurysm (HP:0002617)2.33263055
53Coronal craniosynostosis (HP:0004440)2.32261630
54* Dilatation of the ascending aorta (HP:0005111)2.31802633
55Abnormality of the parietal bone (HP:0002696)2.31405663
56Hypoventilation (HP:0002791)2.30353522
57Abnormality of the phalanges of the hallux (HP:0010057)2.30100892
58Cutaneous syndactyly (HP:0012725)2.27410503
59Abnormality of the ischium (HP:0003174)2.23947458
60Broad thumb (HP:0011304)2.20595603
61Joint laxity (HP:0001388)2.20227368
62Short middle phalanx of the 5th finger (HP:0004220)2.18534457
63Renovascular hypertension (HP:0100817)2.18394204
64Bell-shaped thorax (HP:0001591)2.16846505
65Wormian bones (HP:0002645)2.16822755
66Partial duplication of the phalanx of hand (HP:0009999)2.15028604
67Preaxial foot polydactyly (HP:0001841)2.12092654
68Slender build (HP:0001533)2.12000640
69Broad ribs (HP:0000885)2.11835550
70Broad phalanx (HP:0006009)2.11604145
71Spinal rigidity (HP:0003306)2.11001485
72Patent foramen ovale (HP:0001655)2.09232810
73Flat cornea (HP:0007720)2.08472725
74Lymphangioma (HP:0100764)2.06756995
75Broad phalanges of the hand (HP:0009768)2.06297116
76Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.06248601
77Broad finger (HP:0001500)2.05678781
78Overgrowth (HP:0001548)2.05010988
79Absent frontal sinuses (HP:0002688)2.04144614
80Ulnar bowing (HP:0003031)2.02775820
81Abnormality of the distal phalanx of the thumb (HP:0009617)2.01808406
82Primary atrial arrhythmia (HP:0001692)2.01708569
83* Ectopia lentis (HP:0001083)2.00765495
84Biconcave vertebral bodies (HP:0004586)2.00663336
85Diastasis recti (HP:0001540)2.00315828
86Infantile muscular hypotonia (HP:0008947)2.00062393
87Hyperextensible skin (HP:0000974)1.98940661
88Supraventricular arrhythmia (HP:0005115)1.98681955
89Vertebral clefting (HP:0008428)1.98322287
90Camptodactyly of toe (HP:0001836)1.96442973
91Abnormal delivery (HP:0001787)1.96107178
92Short 5th finger (HP:0009237)1.93578456
93Mildly elevated creatine phosphokinase (HP:0008180)1.93510433
94Vascular tortuosity (HP:0004948)1.93268050
95Partial duplication of thumb phalanx (HP:0009944)1.93136065
96Hypoplasia of the iris (HP:0007676)1.91864043
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.91835658
98Osteolytic defects of the hand bones (HP:0009699)1.91835658
99Supraventricular tachycardia (HP:0004755)1.91434234
100Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89668169
101Thin bony cortex (HP:0002753)1.89467740
102Abnormality of the lumbar spine (HP:0100712)1.89323661
103Inguinal hernia (HP:0000023)1.86941034
104Trigonocephaly (HP:0000243)1.85488575
105Abnormality of the 2nd finger (HP:0004100)1.84760955
106Pulmonary artery stenosis (HP:0004415)1.84672011
107Cervical subluxation (HP:0003308)1.82615861
108Supernumerary ribs (HP:0005815)1.82395229
109Narrow palate (HP:0000189)1.82184782
110Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.82022972
111Hypoplastic ischia (HP:0003175)1.81996182
112Hypoplasia of the maxilla (HP:0000327)1.81964541
113Mild short stature (HP:0003502)1.81815787
114Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.81375650
115Broad hallux (HP:0010055)1.81074322
116* Limited hip movement (HP:0008800)1.80749437
117Abnormality of the acetabulum (HP:0003170)1.80527753
118Abnormality of the peritoneum (HP:0002585)1.80228234
119Broad palm (HP:0001169)1.78944659
120Abnormal atrioventricular conduction (HP:0005150)1.78923328
121Heart block (HP:0012722)1.77357288
122Selective tooth agenesis (HP:0001592)1.77126452
123Atresia of the external auditory canal (HP:0000413)1.76842143
124Abnormality of the middle phalanges of the toes (HP:0010183)1.75570064
125Arterial tortuosity (HP:0005116)1.74108737
126Bifid tongue (HP:0010297)1.73778385
127Subacute progressive viral hepatitis (HP:0006572)1.73523264
128Dislocated radial head (HP:0003083)1.73181972
129Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.72431625
130Protruding ear (HP:0000411)1.72273430
131Abnormality of the pubic bones (HP:0003172)1.72258729
132Breech presentation (HP:0001623)1.71597673
133Cupped ribs (HP:0000887)1.71108347
134Abnormality of the nasolacrimal system (HP:0000614)1.70625674
135Abnormality of the calcaneus (HP:0008364)1.69454095
136Arnold-Chiari malformation (HP:0002308)1.69414475
137Long eyelashes (HP:0000527)1.68430484
138Dilated cardiomyopathy (HP:0001644)1.68041034
139Thoracolumbar scoliosis (HP:0002944)1.67668191
140Abnormality of the radial head (HP:0003995)1.67235339
141Myelomeningocele (HP:0002475)1.67172118
142Aortic regurgitation (HP:0001659)1.66998563
143Abnormality of the fetal cardiovascular system (HP:0010948)1.66184376
144Abnormal umbilical cord blood vessels (HP:0011403)1.66184376
145Single umbilical artery (HP:0001195)1.66184376
146Turricephaly (HP:0000262)1.65219729

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FLT35.41589872
2DDR25.07641676
3LATS14.79694313
4PDGFRA3.24536622
5EPHB22.83570704
6EPHA32.74148194
7TTN2.50355302
8LATS22.45278401
9TRIB32.43925867
10PKN22.41694291
11SIK12.28912150
12GRK72.13052069
13STK32.09457358
14MAP3K102.03565735
15AKT32.00118588
16MKNK11.89655344
17CDK121.89565700
18FGFR11.69304777
19PAK21.57854961
20DMPK1.54002359
21PTK61.52398187
22ICK1.46978980
23RIPK11.46680204
24FGFR21.42043687
25STK38L1.41589661
26STK381.40297262
27MTOR1.36131917
28CDC71.34593373
29BRD41.33619055
30MKNK21.31856740
31ERBB31.31540948
32CAMK1G1.26877208
33PAK41.24952524
34PRKD31.23636705
35PDGFRB1.23135653
36NUAK11.19721900
37TGFBR21.18847406
38NTRK11.12307327
39EPHA41.08643824
40RET1.04918452
41PTK21.03877541
42TGFBR11.02857684
43CAMK1D1.02715729
44MET1.02250200
45PTK2B1.01867275
46ERBB21.01429828
47NEK21.00736357
48WNK10.98825911
49FER0.98356943
50PLK30.98313562
51PLK20.97505376
52OBSCN0.95144499
53CDK60.89996908
54PAK30.86944657
55ILK0.86363986
56ROCK10.85806388
57CLK10.85448356
58NEK90.83758125
59TTK0.83712213
60KSR10.82983302
61CSNK1A1L0.81520434
62PIK3CG0.79397556
63PIK3CA0.78905654
64BMX0.78731233
65CAMK10.78081294
66CDK70.72071774
67STK240.70511911
68MAPK70.69614830
69CDC42BPA0.64594483
70CHEK20.60825810
71EEF2K0.60126794
72PASK0.58775132
73TYRO30.57876580
74SCYL20.57327920
75PNCK0.57122992
76ERBB40.56541685
77RPS6KA40.54951634
78TNIK0.54748446
79MYLK0.54399446
80STK40.54299220
81ZAK0.53569485
82CSNK1G10.52317427
83TRPM70.51971669
84LIMK10.50647163
85PRKCH0.50227576
86CHEK10.49719435
87RAF10.49558392
88ROCK20.49038910
89ATR0.48822211
90CDK80.48285987
91MELK0.46934980
92ATM0.46419846
93TESK10.46048403
94ADRBK10.45370340
95LRRK20.44834423
96AKT10.44287356
97CDK10.43933166
98MAP3K60.42989113
99SRPK10.42554642
100RPS6KA20.42303571
101RPS6KB20.42251402
102MAPK10.42052553
103DYRK1B0.41992281
104PRKD20.41005431
105MAP3K80.39914231
106CASK0.38233060
107MOS0.37656690
108BRSK20.36969332
109PLK10.36485741
110CAMK2D0.36474325
111BCR0.36010265
112SRC0.35406154
113CDK20.34845871
114CAMK40.33853079
115INSR0.33836915
116CDK40.33754934
117FGFR30.33697467
118KDR0.33549160
119MAP3K70.33259809
120PRKDC0.32801845
121AURKB0.31736531
122MAPK80.31625218
123GSK3A0.31157969
124MAPK140.30976123
125TIE10.30259296
126LMTK20.26238835
127MAP3K50.24605569
128MAP3K120.24024566
129PRKCE0.23731386
130NLK0.21709999
131CAMK2A0.20369790
132DAPK30.19798724
133PLK40.19265909
134PRKAA20.19230615
135MAPK100.18356792
136PRKD10.17592855
137PRKAA10.17407564
138MAP2K10.16932006
139TAF10.15951282

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.81927455
2ECM-receptor interaction_Homo sapiens_hsa045123.56110187
3Hedgehog signaling pathway_Homo sapiens_hsa043403.20620827
4Hippo signaling pathway_Homo sapiens_hsa043902.80336276
5Protein digestion and absorption_Homo sapiens_hsa049742.65298121
6Focal adhesion_Homo sapiens_hsa045102.53991925
7Adherens junction_Homo sapiens_hsa045202.47262419
8TGF-beta signaling pathway_Homo sapiens_hsa043502.35338994
9Proteoglycans in cancer_Homo sapiens_hsa052052.21772322
10MicroRNAs in cancer_Homo sapiens_hsa052062.08485088
11Wnt signaling pathway_Homo sapiens_hsa043102.06609647
12Dilated cardiomyopathy_Homo sapiens_hsa054141.96103349
13Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.91877564
14Axon guidance_Homo sapiens_hsa043601.90868897
15Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.88744080
16Cell cycle_Homo sapiens_hsa041101.88648940
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.82055726
18Small cell lung cancer_Homo sapiens_hsa052221.79138130
19Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.70124081
20Amoebiasis_Homo sapiens_hsa051461.60416762
21Melanogenesis_Homo sapiens_hsa049161.58681707
22Notch signaling pathway_Homo sapiens_hsa043301.56915348
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.55125736
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.52909754
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52824296
26Prostate cancer_Homo sapiens_hsa052151.52198755
27Viral myocarditis_Homo sapiens_hsa054161.50262387
28Tight junction_Homo sapiens_hsa045301.49313286
29Chronic myeloid leukemia_Homo sapiens_hsa052201.47787609
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46179440
31Pathways in cancer_Homo sapiens_hsa052001.43928051
32PI3K-Akt signaling pathway_Homo sapiens_hsa041511.40043123
33Colorectal cancer_Homo sapiens_hsa052101.36737496
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.35346706
35HTLV-I infection_Homo sapiens_hsa051661.34982947
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31932153
37Bladder cancer_Homo sapiens_hsa052191.27929582
38Melanoma_Homo sapiens_hsa052181.26204133
39Lysine degradation_Homo sapiens_hsa003101.23187796
40Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.14630346
41Endometrial cancer_Homo sapiens_hsa052131.13907506
42mRNA surveillance pathway_Homo sapiens_hsa030151.11462995
43Glioma_Homo sapiens_hsa052141.10868493
44Cardiac muscle contraction_Homo sapiens_hsa042601.05870135
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03998759
46p53 signaling pathway_Homo sapiens_hsa041151.02524304
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99270103
48Oocyte meiosis_Homo sapiens_hsa041140.96686977
49Rap1 signaling pathway_Homo sapiens_hsa040150.95209545
50Pancreatic cancer_Homo sapiens_hsa052120.94325870
51Spliceosome_Homo sapiens_hsa030400.90752174
52RNA transport_Homo sapiens_hsa030130.90224385
53Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85895641
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.83447416
55Central carbon metabolism in cancer_Homo sapiens_hsa052300.83439395
56Thyroid cancer_Homo sapiens_hsa052160.83346147
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80162710
58Renal cell carcinoma_Homo sapiens_hsa052110.80091003
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79160613
60Viral carcinogenesis_Homo sapiens_hsa052030.79103736
61Steroid biosynthesis_Homo sapiens_hsa001000.77448224
62Estrogen signaling pathway_Homo sapiens_hsa049150.75945537
63Renin-angiotensin system_Homo sapiens_hsa046140.75007125
64Platelet activation_Homo sapiens_hsa046110.74890425
65Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.73589947
66Gap junction_Homo sapiens_hsa045400.73505050
67mTOR signaling pathway_Homo sapiens_hsa041500.72863378
68Calcium signaling pathway_Homo sapiens_hsa040200.71274251
69FoxO signaling pathway_Homo sapiens_hsa040680.68720939
70Ovarian steroidogenesis_Homo sapiens_hsa049130.67069218
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65685862
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.64697610
73Hepatitis B_Homo sapiens_hsa051610.62833948
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61738451
75Non-small cell lung cancer_Homo sapiens_hsa052230.61584592
76Malaria_Homo sapiens_hsa051440.60073679
77Systemic lupus erythematosus_Homo sapiens_hsa053220.59148975
78Dorso-ventral axis formation_Homo sapiens_hsa043200.58445055
79Choline metabolism in cancer_Homo sapiens_hsa052310.56828487
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.55902255
81ErbB signaling pathway_Homo sapiens_hsa040120.55883469
82Alcoholism_Homo sapiens_hsa050340.55133020
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54581188
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54078724
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53496101
86Toxoplasmosis_Homo sapiens_hsa051450.51913448
87Insulin resistance_Homo sapiens_hsa049310.48669274
88Vascular smooth muscle contraction_Homo sapiens_hsa042700.46839162
89AMPK signaling pathway_Homo sapiens_hsa041520.45616553
90MAPK signaling pathway_Homo sapiens_hsa040100.44689030
91RNA degradation_Homo sapiens_hsa030180.43290565
92Thyroid hormone synthesis_Homo sapiens_hsa049180.43064339
93GnRH signaling pathway_Homo sapiens_hsa049120.42481512
94Glucagon signaling pathway_Homo sapiens_hsa049220.40140482
95HIF-1 signaling pathway_Homo sapiens_hsa040660.40000031
96Ras signaling pathway_Homo sapiens_hsa040140.39623972
97Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39500216
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.38602021
99cAMP signaling pathway_Homo sapiens_hsa040240.38103042
100Insulin signaling pathway_Homo sapiens_hsa049100.37368208
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35737223
102Mineral absorption_Homo sapiens_hsa049780.33878170
103Prion diseases_Homo sapiens_hsa050200.33212110
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32922370
105Inositol phosphate metabolism_Homo sapiens_hsa005620.31857923
106Oxytocin signaling pathway_Homo sapiens_hsa049210.31248506
107Renin secretion_Homo sapiens_hsa049240.31195427
108N-Glycan biosynthesis_Homo sapiens_hsa005100.30402572
109Cocaine addiction_Homo sapiens_hsa050300.29766180
110Endocytosis_Homo sapiens_hsa041440.29398773
111Pancreatic secretion_Homo sapiens_hsa049720.28587498
112Shigellosis_Homo sapiens_hsa051310.28191439
113Insulin secretion_Homo sapiens_hsa049110.26232742
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.26188470
115Non-homologous end-joining_Homo sapiens_hsa034500.24990150
116Gastric acid secretion_Homo sapiens_hsa049710.23183453
117Prolactin signaling pathway_Homo sapiens_hsa049170.21898300

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