FBN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a memebr of the fibrillin protein family. Fibrillins are extracellular matrix molecules that assemble into microfibrils in many connective tissues. This gene is most highly expressed in fetal tissues and its protein product is localized to extracellular microfibrils of developing skeletal elements, skin, lung, kidney, and skeletal muscle. This gene is potentially involved in Weill-Marchesani syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gene silencing by RNA (GO:0060966)6.44208249
2regulation of posttranscriptional gene silencing (GO:0060147)6.44208249
3regulation of gene silencing by miRNA (GO:0060964)6.44208249
4paraxial mesoderm development (GO:0048339)6.11158980
5pre-miRNA processing (GO:0031054)5.31955475
6planar cell polarity pathway involved in neural tube closure (GO:0090179)4.98863365
7regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.66792404
8convergent extension (GO:0060026)4.64179525
9lung-associated mesenchyme development (GO:0060484)4.57224511
10presynaptic membrane assembly (GO:0097105)4.19784365
11notochord development (GO:0030903)4.14171754
12regulation of cell fate specification (GO:0042659)4.01647082
13heterochromatin organization (GO:0070828)3.96794780
14lateral sprouting from an epithelium (GO:0060601)3.94541507
15pyrimidine nucleobase catabolic process (GO:0006208)3.81989817
16G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.72805042
17establishment of apical/basal cell polarity (GO:0035089)3.65565315
18establishment of monopolar cell polarity (GO:0061162)3.64937566
19establishment or maintenance of monopolar cell polarity (GO:0061339)3.64937566
20negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.64644004
21negative regulation of translation, ncRNA-mediated (GO:0040033)3.64644004
22regulation of translation, ncRNA-mediated (GO:0045974)3.64644004
23outer ear morphogenesis (GO:0042473)3.63545055
24positive regulation of SMAD protein import into nucleus (GO:0060391)3.59816361
25protein-DNA complex disassembly (GO:0032986)3.59545420
26nucleosome disassembly (GO:0006337)3.59545420
27dorsal/ventral axis specification (GO:0009950)3.56542906
28presynaptic membrane organization (GO:0097090)3.50500298
29Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.48889811
30regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.39420018
31regulation of establishment of planar polarity (GO:0090175)3.35888946
32mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.34688956
33postsynaptic membrane organization (GO:0001941)3.30745897
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.29039342
35axon extension involved in axon guidance (GO:0048846)3.29039342
36regulation of gene silencing (GO:0060968)3.21033960
37non-canonical Wnt signaling pathway (GO:0035567)3.16771263
38establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.13571034
39positive regulation of catenin import into nucleus (GO:0035413)3.09749380
40negative regulation of cell fate specification (GO:0009996)3.05256485
41branching involved in salivary gland morphogenesis (GO:0060445)3.04013903
42negative regulation of gene silencing (GO:0060969)3.03604343
43somatic stem cell division (GO:0048103)3.03519187
44regulation of non-canonical Wnt signaling pathway (GO:2000050)3.01082485
45regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.00353930
46vocalization behavior (GO:0071625)2.99390047
47histone arginine methylation (GO:0034969)2.99221149
48limb bud formation (GO:0060174)2.95182613
49cell migration in hindbrain (GO:0021535)2.94481084
50digestive tract morphogenesis (GO:0048546)2.93718229
51regulation of stem cell maintenance (GO:2000036)2.90130821
52L-serine metabolic process (GO:0006563)2.90024602
53establishment or maintenance of apical/basal cell polarity (GO:0035088)2.86776497
54establishment or maintenance of bipolar cell polarity (GO:0061245)2.86776497
55spinal cord development (GO:0021510)2.86471917
56inner ear receptor cell development (GO:0060119)2.83115739
57neuron cell-cell adhesion (GO:0007158)2.79006062
58neural tube closure (GO:0001843)2.77527624
59cell surface receptor signaling pathway involved in heart development (GO:0061311)2.76253985
60regulation of cell fate commitment (GO:0010453)2.75697858
61tube closure (GO:0060606)2.75679553
62somite development (GO:0061053)2.74847040
63nucleobase catabolic process (GO:0046113)2.73777659
64kidney morphogenesis (GO:0060993)2.73416103
65polarized epithelial cell differentiation (GO:0030859)2.72707137
66mesenchymal to epithelial transition (GO:0060231)2.72654697
67regulation of development, heterochronic (GO:0040034)2.71672594
68negative regulation of histone methylation (GO:0031061)2.71549482
69regulation of catenin import into nucleus (GO:0035412)2.71406392
70cell fate commitment involved in formation of primary germ layer (GO:0060795)2.70099079
71regulation of mesoderm development (GO:2000380)2.68139233
72head development (GO:0060322)2.67273099
73neural tube development (GO:0021915)2.66228994
74post-anal tail morphogenesis (GO:0036342)2.66186848
75establishment of integrated proviral latency (GO:0075713)2.65895405
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.64239995
77negative regulation of androgen receptor signaling pathway (GO:0060766)2.62803480
78generation of neurons (GO:0048699)2.61520064
79establishment of planar polarity (GO:0001736)2.61425047
80establishment of tissue polarity (GO:0007164)2.61425047
81gastrulation with mouth forming second (GO:0001702)2.60533621
82olfactory bulb development (GO:0021772)2.59429138
83DNA unwinding involved in DNA replication (GO:0006268)2.57963938
84midbrain development (GO:0030901)2.56843881
85regulation of SMAD protein import into nucleus (GO:0060390)2.54888968
86regulation of histone H3-K9 methylation (GO:0051570)2.52324062
87regulation of gastrulation (GO:0010470)2.51659236
88cranial nerve development (GO:0021545)2.51602316
89chromatin assembly (GO:0031497)2.51065787
90axonal fasciculation (GO:0007413)2.50798233
91hindbrain development (GO:0030902)2.50529434
92prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.49177654
93negative regulation of cell fate commitment (GO:0010454)2.48412586
94apical protein localization (GO:0045176)2.47180820
95neuron recognition (GO:0008038)2.47087405
96regulation of chromatin silencing (GO:0031935)2.46778540
97hippo signaling (GO:0035329)2.45329552
98positive regulation of gastrulation (GO:2000543)2.43973180
99body morphogenesis (GO:0010171)2.43664772
100regulation of timing of cell differentiation (GO:0048505)2.40994837

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.96252319
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.80288019
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.10817751
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.91204514
5E2F7_22180533_ChIP-Seq_HELA_Human2.81493321
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.68252364
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.68252364
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.68252364
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.54450175
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.54181759
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.48131848
12POU5F1_16153702_ChIP-ChIP_HESCs_Human2.27819343
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.24007278
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.23978572
15SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.22018663
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.20128980
17ERG_21242973_ChIP-ChIP_JURKAT_Human2.15797943
18SOX2_16153702_ChIP-ChIP_HESCs_Human2.14905447
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.11778168
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.08475240
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98695828
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.94230545
23RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.91450918
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.88257622
25ISL1_27105846_Chip-Seq_CPCs_Mouse1.84138986
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.82765508
27SOX2_18555785_ChIP-Seq_MESCs_Mouse1.81715523
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.75211918
29ZFP281_27345836_Chip-Seq_ESCs_Mouse1.73342970
30GATA1_26923725_Chip-Seq_HPCs_Mouse1.70432647
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.70035095
32GBX2_23144817_ChIP-Seq_PC3_Human1.69837755
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.61031938
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.61031938
35TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59831148
36EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59036203
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57052917
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57052917
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56772821
40NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.56622033
41WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56605495
42HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54755663
43POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.53946306
44NANOG_16153702_ChIP-ChIP_HESCs_Human1.52919518
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.52852541
46* DROSHA_22980978_ChIP-Seq_HELA_Human1.48949651
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45851015
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43877464
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41534502
50TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.41085967
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41024514
52TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.38952232
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38627553
54TBX3_20139965_ChIP-Seq_ESCs_Mouse1.37427452
55TBX3_20139965_ChIP-Seq_MESCs_Mouse1.36352467
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.35677583
57POU5F1_16518401_ChIP-PET_MESCs_Mouse1.35334708
58RING1B_27294783_Chip-Seq_ESCs_Mouse1.35216276
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35103934
60NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.32927694
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31770499
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.31060294
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29654805
64EZH2_27294783_Chip-Seq_ESCs_Mouse1.28796274
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.27770669
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27298276
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.26813428
68RNF2_27304074_Chip-Seq_NSC_Mouse1.26010515
69REST_21632747_ChIP-Seq_MESCs_Mouse1.24852754
70SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24070644
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23921017
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.22337298
73STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.22028215
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.19099986
75ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16563711
76SMAD3_21741376_ChIP-Seq_ESCs_Human1.15677114
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13882198
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11451309
79SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10598332
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10046321
81TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07428627
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06025265
83AR_21572438_ChIP-Seq_LNCaP_Human1.05958039
84SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02180609
85CTCF_27219007_Chip-Seq_Bcells_Human1.01549238
86SOX9_26525672_Chip-Seq_HEART_Mouse1.00178626
87REST_18959480_ChIP-ChIP_MESCs_Mouse0.99923568
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99543550
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.98729808
90RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98729061
91SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98199060
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.97642884
93* KDM2B_26808549_Chip-Seq_K562_Human0.95465674
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95251369
95TP53_20018659_ChIP-ChIP_R1E_Mouse0.94490037
96SOX3_22085726_ChIP-Seq_NPCs_Mouse0.93496222
97ZNF274_21170338_ChIP-Seq_K562_Hela0.93341798
98* AR_19668381_ChIP-Seq_PC3_Human0.92972598
99WT1_25993318_ChIP-Seq_PODOCYTE_Human0.91679699
100FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90703276

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.82605715
2MP0000566_synostosis3.33026154
3MP0002254_reproductive_system_inflammat3.20942267
4MP0003122_maternal_imprinting2.77244393
5MP0005377_hearing/vestibular/ear_phenot2.67730634
6MP0003878_abnormal_ear_physiology2.67730634
7MP0003890_abnormal_embryonic-extraembry2.55284175
8MP0003937_abnormal_limbs/digits/tail_de2.31854768
9MP0000537_abnormal_urethra_morphology2.31334893
10MP0003119_abnormal_digestive_system2.28460777
11MP0000049_abnormal_middle_ear2.15386705
12MP0001293_anophthalmia2.14702697
13MP0001299_abnormal_eye_distance/2.04561434
14MP0006292_abnormal_olfactory_placode2.01265830
15MP0009672_abnormal_birth_weight2.01060532
16MP0000778_abnormal_nervous_system2.00096168
17MP0002697_abnormal_eye_size1.99189317
18MP0003121_genomic_imprinting1.98439014
19MP0004133_heterotaxia1.97622094
20MP0003941_abnormal_skin_development1.88410703
21MP0003385_abnormal_body_wall1.84344813
22MP0000428_abnormal_craniofacial_morphol1.76459567
23MP0002233_abnormal_nose_morphology1.75346850
24MP0002938_white_spotting1.73547475
25MP0003567_abnormal_fetal_cardiomyocyte1.72842681
26MP0003787_abnormal_imprinting1.67411118
27MP0003136_yellow_coat_color1.65571345
28MP0003861_abnormal_nervous_system1.64243259
29MP0003938_abnormal_ear_development1.61289283
30MP0003283_abnormal_digestive_organ1.59042918
31MP0002249_abnormal_larynx_morphology1.56023389
32MP0004859_abnormal_synaptic_plasticity1.50307397
33MP0003693_abnormal_embryo_hatching1.48106185
34MP0002111_abnormal_tail_morphology1.47752601
35MP0003942_abnormal_urinary_system1.47238137
36MP0008877_abnormal_DNA_methylation1.45584863
37MP0002084_abnormal_developmental_patter1.43968422
38MP0001849_ear_inflammation1.43863688
39MP0001286_abnormal_eye_development1.43515652
40MP0001984_abnormal_olfaction1.39340024
41MP0002085_abnormal_embryonic_tissue1.38163175
42MP0004858_abnormal_nervous_system1.36911867
43MP0003123_paternal_imprinting1.36588366
44MP0003755_abnormal_palate_morphology1.35682746
45MP0002653_abnormal_ependyma_morphology1.30736415
46MP0009703_decreased_birth_body1.29764178
47MP0000432_abnormal_head_morphology1.27861894
48MP0005499_abnormal_olfactory_system1.27006204
49MP0005394_taste/olfaction_phenotype1.27006204
50MP0002116_abnormal_craniofacial_bone1.24368465
51MP0003935_abnormal_craniofacial_develop1.23519610
52MP0008932_abnormal_embryonic_tissue1.22186101
53MP0003115_abnormal_respiratory_system1.20948030
54MP0002092_abnormal_eye_morphology1.20023809
55MP0000579_abnormal_nail_morphology1.17027810
56MP0004197_abnormal_fetal_growth/weight/1.11216910
57MP0002152_abnormal_brain_morphology1.08246065
58MP0009053_abnormal_anal_canal1.07754026
59MP0000631_abnormal_neuroendocrine_gland1.06965325
60MP0004957_abnormal_blastocyst_morpholog1.05802182
61MP0002089_abnormal_postnatal_growth/wei1.04730255
62MP0001672_abnormal_embryogenesis/_devel1.03975794
63MP0005380_embryogenesis_phenotype1.03975794
64MP0000955_abnormal_spinal_cord1.01250440
65MP0001529_abnormal_vocalization0.99980152
66MP0004272_abnormal_basement_membrane0.99693583
67MP0002081_perinatal_lethality0.99412192
68MP0002102_abnormal_ear_morphology0.98675938
69MP0001730_embryonic_growth_arrest0.98247081
70MP0003111_abnormal_nucleus_morphology0.97933282
71MP0008789_abnormal_olfactory_epithelium0.97759507
72MP0004270_analgesia0.97276734
73MP0002736_abnormal_nociception_after0.95353157
74MP0000026_abnormal_inner_ear0.94763711
75MP0002751_abnormal_autonomic_nervous0.93424937
76MP0002184_abnormal_innervation0.93289880
77MP0000534_abnormal_ureter_morphology0.93051394
78MP0009250_abnormal_appendicular_skeleto0.92801863
79MP0006276_abnormal_autonomic_nervous0.92375661
80MP0009384_cardiac_valve_regurgitation0.90583597
81MP0003880_abnormal_central_pattern0.90213497
82MP0003984_embryonic_growth_retardation0.89523630
83MP0001485_abnormal_pinna_reflex0.87715454
84MP0002088_abnormal_embryonic_growth/wei0.86880926
85MP0005257_abnormal_intraocular_pressure0.85390092
86MP0001177_atelectasis0.84612667
87MP0002932_abnormal_joint_morphology0.84235527
88MP0001346_abnormal_lacrimal_gland0.83103603
89MP0002752_abnormal_somatic_nervous0.83077114
90MP0008057_abnormal_DNA_replication0.82585364
91MP0002734_abnormal_mechanical_nocicepti0.82543702
92MP0002114_abnormal_axial_skeleton0.81753893
93MP0000462_abnormal_digestive_system0.80730012
94MP0003635_abnormal_synaptic_transmissio0.77975404
95MP0002882_abnormal_neuron_morphology0.77862330
96MP0005391_vision/eye_phenotype0.77268181
97MP0000762_abnormal_tongue_morphology0.76976737
98MP0001697_abnormal_embryo_size0.76642313
99MP0001340_abnormal_eyelid_morphology0.76436458
100MP0002735_abnormal_chemical_nociception0.75920163

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)3.96485414
2Vitreoretinal degeneration (HP:0000655)3.75614197
3Choanal stenosis (HP:0000452)3.46964505
4Turricephaly (HP:0000262)3.14248927
5Septo-optic dysplasia (HP:0100842)3.02035542
6Cutaneous finger syndactyly (HP:0010554)2.99585662
7Cutaneous syndactyly (HP:0012725)2.98220805
8Abnormality of the labia minora (HP:0012880)2.90032131
9Bronchomalacia (HP:0002780)2.89840511
10Shallow orbits (HP:0000586)2.84684247
11Broad metatarsal (HP:0001783)2.80468799
12Bilateral microphthalmos (HP:0007633)2.79268622
13Broad thumb (HP:0011304)2.76741769
14High anterior hairline (HP:0009890)2.76093187
15Trigonocephaly (HP:0000243)2.72210380
16Short 4th metacarpal (HP:0010044)2.71938302
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71938302
18Skull defect (HP:0001362)2.63543745
19Anophthalmia (HP:0000528)2.61307160
20Cortical dysplasia (HP:0002539)2.53984620
21Coronal craniosynostosis (HP:0004440)2.53388111
22Midline defect of the nose (HP:0004122)2.53128480
23Broad phalanges of the hand (HP:0009768)2.48392984
24Preaxial foot polydactyly (HP:0001841)2.43473136
25Abnormality of the pubic bones (HP:0003172)2.42549882
26Broad finger (HP:0001500)2.41958764
27Aqueductal stenosis (HP:0002410)2.41438448
28Colon cancer (HP:0003003)2.39435202
29Myelomeningocele (HP:0002475)2.34398237
30Tracheomalacia (HP:0002779)2.29702381
31Partial duplication of thumb phalanx (HP:0009944)2.28327061
32Broad long bones (HP:0005622)2.24917216
33Broad phalanx (HP:0006009)2.24825932
34Aplasia/Hypoplasia of the sternum (HP:0006714)2.23313370
35Morphological abnormality of the middle ear (HP:0008609)2.18621032
36Renal hypoplasia (HP:0000089)2.15933370
37Metaphyseal cupping (HP:0003021)2.13733943
38Aplasia involving bones of the extremities (HP:0009825)2.12667558
39Aplasia involving bones of the upper limbs (HP:0009823)2.12667558
40Aplasia of the phalanges of the hand (HP:0009802)2.12667558
41Rib fusion (HP:0000902)2.11330119
42Mixed hearing impairment (HP:0000410)2.09233921
43Bifid tongue (HP:0010297)2.07904688
44Abnormality of the 4th metacarpal (HP:0010012)2.07068832
45Broad palm (HP:0001169)2.06730526
46Hypoplastic ischia (HP:0003175)2.06373805
47Abnormality of the aortic arch (HP:0012303)2.05483589
48Omphalocele (HP:0001539)2.04435258
49Partial duplication of the phalanx of hand (HP:0009999)2.02000730
50Intestinal atresia (HP:0011100)2.00298749
51Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97584709
52Abnormality of abdominal situs (HP:0011620)1.97492190
53Abdominal situs inversus (HP:0003363)1.97492190
54Abnormality of the ischium (HP:0003174)1.95269436
55Synostosis involving the elbow (HP:0003938)1.94390235
56Humeroradial synostosis (HP:0003041)1.94390235
57Maternal diabetes (HP:0009800)1.93872604
58Vertebral arch anomaly (HP:0008438)1.91951188
59Neonatal short-limb short stature (HP:0008921)1.90980668
60Abnormality of the middle phalanges of the toes (HP:0010183)1.89895174
61Overriding aorta (HP:0002623)1.88133096
62Nephroblastoma (Wilms tumor) (HP:0002667)1.87445027
63Stenosis of the external auditory canal (HP:0000402)1.87442140
64Arnold-Chiari malformation (HP:0002308)1.83838459
65Short hallux (HP:0010109)1.81984413
66Absent eyebrow (HP:0002223)1.81594136
67Irregular epiphyses (HP:0010582)1.81079064
68Embryonal renal neoplasm (HP:0011794)1.80810095
69Synostosis of carpal bones (HP:0005048)1.80499996
70Abnormality of the calcaneus (HP:0008364)1.80293294
71Renovascular hypertension (HP:0100817)1.79051671
72Labial hypoplasia (HP:0000066)1.78637754
73Abnormality of the septum pellucidum (HP:0007375)1.78501595
74Abnormal number of incisors (HP:0011064)1.77515859
75Absent septum pellucidum (HP:0001331)1.77512328
76Vertebral clefting (HP:0008428)1.77395211
77Bicornuate uterus (HP:0000813)1.76699476
78Diastasis recti (HP:0001540)1.75477087
79Carpal bone hypoplasia (HP:0001498)1.75181984
80Abnormal lung lobation (HP:0002101)1.74474059
81Hypoplastic female external genitalia (HP:0012815)1.74255046
82Absent radius (HP:0003974)1.72706004
83Esophageal atresia (HP:0002032)1.72396863
84Abnormality of the lacrimal duct (HP:0011481)1.71640422
85Cupped ear (HP:0000378)1.71620277
86Hemivertebrae (HP:0002937)1.71454419
87Abnormality of the antihelix (HP:0009738)1.70427644
88Breast aplasia (HP:0100783)1.70177966
89Aplasia/Hypoplasia of the hallux (HP:0008362)1.69127570
90Severe Myopia (HP:0011003)1.67987833
91Broad toe (HP:0001837)1.67802700
92Partial agenesis of the corpus callosum (HP:0001338)1.67786228
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67546152
94Absent epiphyses (HP:0010577)1.67546152
95Increased nuchal translucency (HP:0010880)1.67088742
96Short middle phalanx of finger (HP:0005819)1.66802875
97Optic nerve hypoplasia (HP:0000609)1.66296140
98Absent forearm bone (HP:0003953)1.66118227
99Aplasia involving forearm bones (HP:0009822)1.66118227
100Abnormality of the parietal bone (HP:0002696)1.65581576

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.79113675
2FGFR23.26186552
3MAPK153.04353964
4MKNK12.69156227
5CASK2.45365020
6LATS12.39558998
7TYRO32.37209884
8DYRK22.21503889
9MKNK22.17976242
10MARK12.08331763
11CDC72.03190473
12BCR1.99139265
13STK38L1.86812307
14EEF2K1.85918156
15MAP3K41.77537972
16CAMK1D1.75405423
17EPHA41.69756551
18TNIK1.67430561
19LATS21.66026841
20CAMK1G1.62876125
21PLK41.60785833
22WNK31.57396830
23BRD41.53031007
24FGFR11.51969222
25CDK121.51438490
26CDK191.51080516
27TAF11.50234687
28TTK1.47418120
29DYRK31.44691035
30BMX1.41140465
31SRPK11.38720299
32EPHB21.35980889
33PASK1.32629852
34PDGFRA1.27693577
35NTRK21.26319830
36FGFR41.18174349
37SMG11.18099700
38INSRR1.17257784
39MAP2K71.14830004
40NEK21.14610657
41NTRK10.98376262
42ERBB20.92371307
43NME10.87277730
44STK30.87257588
45CSNK1G10.85369665
46MARK20.83282339
47TSSK60.83203606
48DDR20.82563074
49MAP3K90.81773917
50DYRK1A0.81075684
51CSNK1G20.76477919
52PLK30.76460487
53NTRK30.75038463
54UHMK10.74527221
55MAP3K60.71260124
56SIK20.70439119
57CHEK20.68671176
58ATR0.68481597
59ICK0.67278818
60DYRK1B0.64128392
61CSNK1A1L0.64104042
62PNCK0.63629834
63SGK2230.63595312
64SGK4940.63595312
65PLK10.62334324
66ZAK0.61085979
67CSNK1G30.60718620
68CAMK40.59988374
69TRIM280.59147159
70ATM0.58910582
71MTOR0.57008589
72CHEK10.56103114
73PRKDC0.55707371
74CDK10.54959208
75PRKCG0.54430978
76CDK20.54285108
77DMPK0.53205751
78CSNK1E0.48923964
79RPS6KA20.48430717
80MAP2K40.48355931
81GSK3B0.47436435
82RIPK10.47390104
83TIE10.46900828
84STK110.46149029
85RPS6KC10.43861376
86RPS6KL10.43861376
87MINK10.43771459
88CSNK1D0.42924090
89MAPK90.41698835
90MAP3K70.41008656
91VRK20.40187991
92RPS6KA10.39884946
93PAK40.39652828
94CDK180.39515302
95CDK11A0.39436556
96CDK150.39039309
97MET0.38924724
98RPS6KA60.38778473
99CDK50.38274870
100MAPK100.38070476

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.85828615
2Hedgehog signaling pathway_Homo sapiens_hsa043402.94218763
3Hippo signaling pathway_Homo sapiens_hsa043902.57942533
4Axon guidance_Homo sapiens_hsa043602.49160954
5Wnt signaling pathway_Homo sapiens_hsa043102.32484999
6Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.32068996
7Adherens junction_Homo sapiens_hsa045202.22988081
8Nicotine addiction_Homo sapiens_hsa050332.06951749
9mRNA surveillance pathway_Homo sapiens_hsa030151.95948080
10Lysine degradation_Homo sapiens_hsa003101.86891587
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83987721
12Tight junction_Homo sapiens_hsa045301.79815812
13Notch signaling pathway_Homo sapiens_hsa043301.79412257
14Melanogenesis_Homo sapiens_hsa049161.68043369
15Non-homologous end-joining_Homo sapiens_hsa034501.66966969
16Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.65812062
17DNA replication_Homo sapiens_hsa030301.56022144
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51051978
19Spliceosome_Homo sapiens_hsa030401.45376720
20Protein digestion and absorption_Homo sapiens_hsa049741.43079351
21Mismatch repair_Homo sapiens_hsa034301.41730212
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40652340
23Cell cycle_Homo sapiens_hsa041101.35296345
24Steroid biosynthesis_Homo sapiens_hsa001001.30597583
25Base excision repair_Homo sapiens_hsa034101.30296680
26Fanconi anemia pathway_Homo sapiens_hsa034601.28958902
27ECM-receptor interaction_Homo sapiens_hsa045121.28404280
28MicroRNAs in cancer_Homo sapiens_hsa052061.27136241
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25352823
30RNA transport_Homo sapiens_hsa030131.21182206
31Taste transduction_Homo sapiens_hsa047421.20342035
32TGF-beta signaling pathway_Homo sapiens_hsa043501.15678226
33Colorectal cancer_Homo sapiens_hsa052101.15549227
34Glutamatergic synapse_Homo sapiens_hsa047241.11172795
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.04940985
36Selenocompound metabolism_Homo sapiens_hsa004501.02258426
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.01615636
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97897615
39GABAergic synapse_Homo sapiens_hsa047270.95881226
40Long-term depression_Homo sapiens_hsa047300.95627942
41Thyroid cancer_Homo sapiens_hsa052160.94156898
42Gap junction_Homo sapiens_hsa045400.93558130
43Circadian entrainment_Homo sapiens_hsa047130.93135425
44Central carbon metabolism in cancer_Homo sapiens_hsa052300.92989826
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.92059192
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.90658246
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89356611
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88135380
49Rap1 signaling pathway_Homo sapiens_hsa040150.85079559
50Endometrial cancer_Homo sapiens_hsa052130.85061930
51Homologous recombination_Homo sapiens_hsa034400.84842504
52Pathways in cancer_Homo sapiens_hsa052000.84777391
53Biosynthesis of amino acids_Homo sapiens_hsa012300.84443430
54Basal transcription factors_Homo sapiens_hsa030220.81731619
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80981672
56Dilated cardiomyopathy_Homo sapiens_hsa054140.79817938
57Ether lipid metabolism_Homo sapiens_hsa005650.76963076
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76352327
59Phototransduction_Homo sapiens_hsa047440.75467557
60Oocyte meiosis_Homo sapiens_hsa041140.75358196
61Morphine addiction_Homo sapiens_hsa050320.71983457
62Proteoglycans in cancer_Homo sapiens_hsa052050.70630488
63Ras signaling pathway_Homo sapiens_hsa040140.70247097
64Dopaminergic synapse_Homo sapiens_hsa047280.68952541
65ErbB signaling pathway_Homo sapiens_hsa040120.68424374
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67332076
67Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63953111
68Cocaine addiction_Homo sapiens_hsa050300.63484749
69Prostate cancer_Homo sapiens_hsa052150.63368018
70Melanoma_Homo sapiens_hsa052180.62628543
71Focal adhesion_Homo sapiens_hsa045100.60721806
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60612320
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.60394058
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57003428
75Alcoholism_Homo sapiens_hsa050340.56569462
76RNA degradation_Homo sapiens_hsa030180.55407576
77AMPK signaling pathway_Homo sapiens_hsa041520.54836615
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54270775
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54069301
80cAMP signaling pathway_Homo sapiens_hsa040240.53468987
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52217601
82Serotonergic synapse_Homo sapiens_hsa047260.51677651
83Oxytocin signaling pathway_Homo sapiens_hsa049210.50709740
84Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50496969
85Choline metabolism in cancer_Homo sapiens_hsa052310.49734441
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49633642
87Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49198217
88MAPK signaling pathway_Homo sapiens_hsa040100.46966747
89Glucagon signaling pathway_Homo sapiens_hsa049220.45790996
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44680521
91Type II diabetes mellitus_Homo sapiens_hsa049300.44403578
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43314595
93Cholinergic synapse_Homo sapiens_hsa047250.43265491
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42268500
95Long-term potentiation_Homo sapiens_hsa047200.42039619
96Nucleotide excision repair_Homo sapiens_hsa034200.40912917
97Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.40382165
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.39151830
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39118996
100Arginine and proline metabolism_Homo sapiens_hsa003300.38768185

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »