FBP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.59199386
2L-phenylalanine catabolic process (GO:0006559)7.59199386
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.30447346
4L-phenylalanine metabolic process (GO:0006558)7.30447346
5aromatic amino acid family catabolic process (GO:0009074)6.90183267
6indole-containing compound catabolic process (GO:0042436)6.26693647
7indolalkylamine catabolic process (GO:0046218)6.26693647
8tryptophan catabolic process (GO:0006569)6.26693647
9glyoxylate metabolic process (GO:0046487)6.24071236
10epoxygenase P450 pathway (GO:0019373)6.21636531
11kynurenine metabolic process (GO:0070189)5.98679301
12tryptophan metabolic process (GO:0006568)5.90120238
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.85948979
14cysteine metabolic process (GO:0006534)5.76326314
15bile acid biosynthetic process (GO:0006699)5.75505139
16urea metabolic process (GO:0019627)5.53052487
17urea cycle (GO:0000050)5.53052487
18glycosphingolipid catabolic process (GO:0046479)5.42260363
19alpha-linolenic acid metabolic process (GO:0036109)5.40091187
20sulfur amino acid catabolic process (GO:0000098)5.38980247
21serine family amino acid catabolic process (GO:0009071)5.34893339
22lysine metabolic process (GO:0006553)5.33974444
23lysine catabolic process (GO:0006554)5.33974444
24fat-soluble vitamin biosynthetic process (GO:0042362)5.29503464
25fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.24287997
26negative regulation of fibrinolysis (GO:0051918)5.21185981
27high-density lipoprotein particle remodeling (GO:0034375)5.16813783
28omega-hydroxylase P450 pathway (GO:0097267)5.12092349
29nitrogen cycle metabolic process (GO:0071941)5.10832451
30homocysteine metabolic process (GO:0050667)5.07237187
31aromatic amino acid family metabolic process (GO:0009072)5.02288860
32glycolipid catabolic process (GO:0019377)5.00229606
33regulation of fibrinolysis (GO:0051917)4.98360266
34protein carboxylation (GO:0018214)4.97351847
35peptidyl-glutamic acid carboxylation (GO:0017187)4.97351847
36amino-acid betaine metabolic process (GO:0006577)4.93996778
37bile acid metabolic process (GO:0008206)4.88601014
38complement activation, alternative pathway (GO:0006957)4.87509651
39regulation of protein activation cascade (GO:2000257)4.84102608
40oligosaccharide catabolic process (GO:0009313)4.81758406
41alpha-amino acid catabolic process (GO:1901606)4.74445569
42tyrosine metabolic process (GO:0006570)4.72454467
43cellular ketone body metabolic process (GO:0046950)4.63640756
44regulation of triglyceride catabolic process (GO:0010896)4.58335335
45regulation of cholesterol esterification (GO:0010872)4.57556544
46drug catabolic process (GO:0042737)4.51149736
47regulation of complement activation (GO:0030449)4.50511305
48reverse cholesterol transport (GO:0043691)4.50239171
49plasma lipoprotein particle remodeling (GO:0034369)4.45260225
50protein-lipid complex remodeling (GO:0034368)4.45260225
51macromolecular complex remodeling (GO:0034367)4.45260225
52drug transmembrane transport (GO:0006855)4.43298810
53indolalkylamine metabolic process (GO:0006586)4.43235011
54serine family amino acid metabolic process (GO:0009069)4.42653255
55cellular amino acid catabolic process (GO:0009063)4.41686624
56urate metabolic process (GO:0046415)4.41644360
57negative regulation of sterol transport (GO:0032372)4.39733057
58negative regulation of cholesterol transport (GO:0032375)4.39733057
59ceramide catabolic process (GO:0046514)4.38909211
60glutamate metabolic process (GO:0006536)4.36798850
61cellular modified amino acid catabolic process (GO:0042219)4.32728059
62triglyceride homeostasis (GO:0070328)4.32397222
63acylglycerol homeostasis (GO:0055090)4.32397222
64glycine metabolic process (GO:0006544)4.31646059
65cellular biogenic amine catabolic process (GO:0042402)4.29933844
66amine catabolic process (GO:0009310)4.29933844
67cellular glucuronidation (GO:0052695)4.24465940
68coenzyme catabolic process (GO:0009109)4.24003886
69benzene-containing compound metabolic process (GO:0042537)4.22114015
70phospholipid efflux (GO:0033700)4.22056761
71angiotensin maturation (GO:0002003)4.22004718
72serine family amino acid biosynthetic process (GO:0009070)4.17745404
73very-low-density lipoprotein particle assembly (GO:0034379)4.14022334
74bile acid and bile salt transport (GO:0015721)4.09705767
75plasma lipoprotein particle clearance (GO:0034381)4.09510946
76short-chain fatty acid metabolic process (GO:0046459)4.06166307
77aldehyde catabolic process (GO:0046185)4.06145971
78exogenous drug catabolic process (GO:0042738)4.05482076
79ketone body metabolic process (GO:1902224)4.01070854
80dicarboxylic acid biosynthetic process (GO:0043650)4.00491988
81imidazole-containing compound metabolic process (GO:0052803)3.99900106
82ethanol oxidation (GO:0006069)3.97280939
83aspartate family amino acid catabolic process (GO:0009068)3.96465759
84arginine metabolic process (GO:0006525)3.94866408
85organic acid catabolic process (GO:0016054)3.89567399
86carboxylic acid catabolic process (GO:0046395)3.89567399
87cholesterol efflux (GO:0033344)3.84746250
88acetyl-CoA metabolic process (GO:0006084)3.84688597
89glucuronate metabolic process (GO:0019585)3.84046913
90uronic acid metabolic process (GO:0006063)3.84046913
91peptide catabolic process (GO:0043171)3.82546418
92fibrinolysis (GO:0042730)3.74124469
932-oxoglutarate metabolic process (GO:0006103)3.72213021
94carnitine metabolic process (GO:0009437)3.72115304
95plasma lipoprotein particle assembly (GO:0034377)3.70863080
96drug transport (GO:0015893)3.70452593
97low-density lipoprotein particle remodeling (GO:0034374)3.67131167
98flavonoid metabolic process (GO:0009812)3.67044267
99cofactor catabolic process (GO:0051187)3.63966419
100regulation of bile acid biosynthetic process (GO:0070857)3.63761010
101fatty acid beta-oxidation (GO:0006635)3.63580584
102fatty acid oxidation (GO:0019395)3.63497576
103hormone catabolic process (GO:0042447)3.63290262
104positive regulation of lipoprotein lipase activity (GO:0051006)3.62757628
105positive regulation of triglyceride lipase activity (GO:0061365)3.62757628
106monocarboxylic acid catabolic process (GO:0072329)3.61562450
107regulation of cholesterol homeostasis (GO:2000188)3.59828655
108phospholipid homeostasis (GO:0055091)3.58402708
109cholesterol homeostasis (GO:0042632)3.57972871
110drug metabolic process (GO:0017144)3.57683289
111lipid oxidation (GO:0034440)3.56424409
112ethanol metabolic process (GO:0006067)3.50180566
113regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.41568429
114complement activation (GO:0006956)3.38794732
115NADH metabolic process (GO:0006734)3.37016851
116amino sugar catabolic process (GO:0046348)3.32793902
117sphingolipid catabolic process (GO:0030149)3.29446492
118membrane lipid catabolic process (GO:0046466)3.26199871
119protein activation cascade (GO:0072376)3.26082588
120phenylpropanoid metabolic process (GO:0009698)3.25552163
121positive regulation of fatty acid biosynthetic process (GO:0045723)3.24993019
122complement activation, classical pathway (GO:0006958)3.24197474
123acute-phase response (GO:0006953)3.22175629
124positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.19634249
125plasma lipoprotein particle organization (GO:0071827)3.14236397
126vitamin D metabolic process (GO:0042359)3.10941086
127protein-lipid complex assembly (GO:0065005)3.00785395
128protein-lipid complex subunit organization (GO:0071825)2.99448329
129regulation of cholesterol storage (GO:0010885)2.98824280
130positive regulation of bone remodeling (GO:0046852)2.98383111
131positive regulation of bone resorption (GO:0045780)2.98383111
132negative regulation of blood coagulation (GO:0030195)2.97616127
133negative regulation of hemostasis (GO:1900047)2.97616127
134blood coagulation, intrinsic pathway (GO:0007597)2.94074039
135lipoprotein transport (GO:0042953)2.93391749
136lipoprotein metabolic process (GO:0042157)2.89595743
137positive regulation of lipid catabolic process (GO:0050996)2.86049302
138alkaloid metabolic process (GO:0009820)2.84316022
139regulation of cholesterol transport (GO:0032374)2.82330128
140regulation of sterol transport (GO:0032371)2.82330128
141response to thyroid hormone (GO:0097066)2.78432514
142cellular response to thyroid hormone stimulus (GO:0097067)2.77395586
143negative regulation of coagulation (GO:0050819)2.77039445
144oxidative demethylation (GO:0070989)2.76582349
145neutrophil activation involved in immune response (GO:0002283)2.72810520
146negative regulation of lipid transport (GO:0032369)2.70825316
147glucose 6-phosphate metabolic process (GO:0051156)2.70700420
148positive regulation of triglyceride metabolic process (GO:0090208)2.69750287
149vitamin biosynthetic process (GO:0009110)2.68017630
150regulation of monocyte differentiation (GO:0045655)2.66965678
151hydrogen peroxide biosynthetic process (GO:0050665)2.62893733

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.29066849
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.10447989
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.73897445
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.41467634
5FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.13525493
6CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.89517060
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.82075634
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.95363363
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.85946103
10IRF8_21731497_ChIP-ChIP_J774_Mouse3.07870418
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.01685904
12IRF8_27001747_Chip-Seq_BMDM_Mouse2.52626753
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41301794
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.25225276
15TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.11260466
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.10169554
17* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07390650
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.7516669
19MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68397795
20* VDR_24763502_ChIP-Seq_THP-1_Human1.64541200
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63182991
22* FOXA2_19822575_ChIP-Seq_HepG2_Human1.59953207
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57522779
24CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53469331
25VDR_21846776_ChIP-Seq_THP-1_Human1.51936420
26RACK7_27058665_Chip-Seq_MCF-7_Human1.51609648
27CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.49182451
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48175940
29ESR1_20079471_ChIP-ChIP_T-47D_Human1.47815668
30* VDR_24787735_ChIP-Seq_THP-1_Human1.47081209
31* HNF4A_19822575_ChIP-Seq_HepG2_Human1.46576164
32CLOCK_20551151_ChIP-Seq_293T_Human1.45909818
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37369984
34HTT_18923047_ChIP-ChIP_STHdh_Human1.36540832
35SPI1_23127762_ChIP-Seq_K562_Human1.36096169
36* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32872269
37RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25690945
38STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24822466
39* SOX2_20726797_ChIP-Seq_SW620_Human1.24306147
40TP63_17297297_ChIP-ChIP_HaCaT_Human1.23892312
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23335639
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21948931
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.20330306
44PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18875615
45SPI1_23547873_ChIP-Seq_NB4_Human1.18663728
46* ELK3_25401928_ChIP-Seq_HUVEC_Human1.18368246
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17181687
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15667236
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14782512
50GATA1_22025678_ChIP-Seq_K562_Human1.14728051
51STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14598110
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11263269
53BCOR_27268052_Chip-Seq_Bcells_Human1.08587979
54RUNX1_27514584_Chip-Seq_MCF-7_Human1.08374427
55SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08370099
56PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08114211
57* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06757836
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05738753
59PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05645109
60BCL6_27268052_Chip-Seq_Bcells_Human1.05531939
61ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.05372159
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.04005256
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02528801
64* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02497762
65* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01935656
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01392368
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01203870
68IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00856654
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00227362
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99478202
71* TCF7_22412390_ChIP-Seq_EML_Mouse0.98965067
72TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.98155360
73KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96751222
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95896622
75* LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91455218
76MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90830543
77GATA1_19941826_ChIP-Seq_K562_Human0.90572922
78RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90221764
79KAP1_22055183_ChIP-Seq_ESCs_Mouse0.90079056
80GATA4_25053715_ChIP-Seq_YYC3_Human0.89425628
81* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89009091
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88811697
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.86596442
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86318795
85STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86277833
86STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86273776
87GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86077681
88STAT1_20625510_ChIP-Seq_HELA_Human0.85069410
89MAF_26560356_Chip-Seq_TH1_Human0.83365277
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.82915238
91* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80805351
92IRF8_22096565_ChIP-ChIP_GC-B_Human0.80426303
93RARA_24833708_ChIP-Seq_LIVER_Mouse0.78819360
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.77414363
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74568529
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73646803
97* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73073517
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.70905268
99BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.70381891
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.69326910
101PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69211185
102CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.69009307
103ZNF263_19887448_ChIP-Seq_K562_Human0.68924868
104ESR2_21235772_ChIP-Seq_MCF-7_Human0.68345212
105AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.68042302
106RARB_24833708_ChIP-Seq_LIVER_Mouse0.64921359
107BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.64780760
108CEBPB_22108803_ChIP-Seq_LS180_Human0.64247332
109ESR1_21235772_ChIP-Seq_MCF-7_Human0.63807269
110STAT3_1855785_ChIP-Seq_MESCs_Mouse0.62864291
111STAT1_17558387_ChIP-Seq_HELA_Human0.61905046
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.61790901
113LXR_22292898_ChIP-Seq_THP-1_Human0.61210971
114RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.61200784
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.60742398
116MYC_19915707_ChIP-ChIP_AK7_Human0.59043037
117ESET_19884257_ChIP-Seq_ESCs_Mouse0.59018762
118* AR_20517297_ChIP-Seq_VCAP_Human0.58016606
119EGR1_19032775_ChIP-ChIP_M12_Human0.57047542
120FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56490209
121P53_21459846_ChIP-Seq_SAOS-2_Human0.56122128
122GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.53718068
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.53690604
124PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.53619012
125NRF2_20460467_ChIP-Seq_MEFs_Mouse0.53144404
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.53144404
127CBP_21632823_ChIP-Seq_H3396_Human0.52605721
128FOXA1_25552417_ChIP-Seq_VCAP_Human0.50855686
129* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.50712781
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.49598613
131TAF2_19829295_ChIP-Seq_ESCs_Human0.49098083
132CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.46282293
133PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.46228420
134GATA6_25053715_ChIP-Seq_YYC3_Human0.45888943
135LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.45568062
136* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45021035
137FOXO3_23340844_ChIP-Seq_DLD1_Human0.44243237
138SOX2_22085726_ChIP-Seq_NPCs_Mouse0.44179655
139MYC_27129775_Chip-Seq_CORNEA_Mouse0.44117617
140CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.44060333
141EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.43538294
142NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.42943925
143* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.42745275
144FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.42722482
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.42060976
146CDX2_22108803_ChIP-Seq_LS180_Human0.41804355
147GATA2_19941826_ChIP-Seq_K562_Human0.41587914
148SPI1_26923725_Chip-Seq_HPCs_Mouse0.41283253
149SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.41195962
150* ERG_20517297_ChIP-Seq_VCAP_Human0.40894238
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.40894045
152* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.40671810
153TET1_21451524_ChIP-Seq_MESCs_Mouse0.40244240
154CSB_26484114_Chip-Seq_FIBROBLAST_Human0.40098066
155E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.40054389
156STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.40044879
157OCT4_20526341_ChIP-Seq_ESCs_Human0.39802946
158RAC3_21632823_ChIP-Seq_H3396_Human0.39767593

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.18832753
2MP0005360_urolithiasis7.95773468
3MP0005085_abnormal_gallbladder_physiolo6.12429068
4MP0005365_abnormal_bile_salt5.95696432
5MP0008875_abnormal_xenobiotic_pharmacok5.08368612
6MP0003806_abnormal_nucleotide_metabolis3.97993650
7MP0003252_abnormal_bile_duct3.86660990
8MP0010329_abnormal_lipoprotein_level3.34675823
9MP0005332_abnormal_amino_acid3.22448599
10MP0003195_calcinosis3.14965605
11MP0009840_abnormal_foam_cell2.96996224
12MP0005083_abnormal_biliary_tract2.78761371
13MP0004019_abnormal_vitamin_homeostasis2.68056393
14MP0001666_abnormal_nutrient_absorption2.47796566
15MP0003172_abnormal_lysosome_physiology2.43085883
16MP0002138_abnormal_hepatobiliary_system2.34547109
17MP0003191_abnormal_cellular_cholesterol2.27910085
18MP0000609_abnormal_liver_physiology2.05812330
19MP0002118_abnormal_lipid_homeostasis2.02751916
20MP0005319_abnormal_enzyme/_coenzyme1.86438261
21MP0002419_abnormal_innate_immunity1.77315184
22MP0001764_abnormal_homeostasis1.73875347
23MP0003868_abnormal_feces_composition1.73110340
24MP0003183_abnormal_peptide_metabolism1.71199116
25MP0009643_abnormal_urine_homeostasis1.68899235
26MP0001835_abnormal_antigen_presentation1.68088610
27MP0005584_abnormal_enzyme/coenzyme_acti1.64633999
28MP0003303_peritoneal_inflammation1.64439894
29MP0009785_altered_susceptibility_to1.56410366
30MP0002148_abnormal_hypersensitivity_rea1.55932496
31MP0005451_abnormal_body_composition1.52885725
32MP0005025_abnormal_response_to1.52174329
33MP0003186_abnormal_redox_activity1.41136928
34MP0010234_abnormal_vibrissa_follicle1.40276157
35MP0010155_abnormal_intestine_physiology1.37698425
36MP0005636_abnormal_mineral_homeostasis1.34469195
37MP0009697_abnormal_copulation1.33017039
38MP0003011_delayed_dark_adaptation1.27468079
39MP0005671_abnormal_response_to1.25384755
40MP0005387_immune_system_phenotype1.22634467
41MP0001790_abnormal_immune_system1.22634467
42MP0002998_abnormal_bone_remodeling1.15676146
43MP0000598_abnormal_liver_morphology1.15390002
44MP0005000_abnormal_immune_tolerance1.14562943
45MP0001533_abnormal_skeleton_physiology1.13218282
46MP0003656_abnormal_erythrocyte_physiolo1.11649396
47MP0000343_altered_response_to1.09053473
48MP0002452_abnormal_antigen_presenting1.09036647
49MP0005647_abnormal_sex_gland1.06527875
50MP0008260_abnormal_autophagy1.04359513
51MP0009764_decreased_sensitivity_to1.03899131
52MP0005670_abnormal_white_adipose1.02830676
53MP0009333_abnormal_splenocyte_physiolog1.02461795
54MP0004043_abnormal_pH_regulation1.01603719
55MP0000604_amyloidosis1.00655832
56MP0001756_abnormal_urination0.99699514
57MP0003705_abnormal_hypodermis_morpholog0.98401989
58MP0003879_abnormal_hair_cell0.98241937
59MP0006036_abnormal_mitochondrial_physio0.96311905
60MP0002723_abnormal_immune_serum0.95106229
61MP0009763_increased_sensitivity_to0.92756473
62MP0001800_abnormal_humoral_immune0.92694877
63MP0005084_abnormal_gallbladder_morpholo0.91027224
64MP0009642_abnormal_blood_homeostasis0.90799408
65MP0008469_abnormal_protein_level0.89330313
66MP0002876_abnormal_thyroid_physiology0.86140384
67MP0002136_abnormal_kidney_physiology0.83878021
68MP0005408_hypopigmentation0.83763864
69MP0005310_abnormal_salivary_gland0.83464582
70MP0002254_reproductive_system_inflammat0.81573410
71MP0004947_skin_inflammation0.81162219
72MP0000858_altered_metastatic_potential0.80982812
73MP0002420_abnormal_adaptive_immunity0.80107634
74MP0001819_abnormal_immune_cell0.79537829
75MP0004883_abnormal_blood_vessel0.78546708
76MP0005397_hematopoietic_system_phenotyp0.78379138
77MP0001545_abnormal_hematopoietic_system0.78379138
78MP0000685_abnormal_immune_system0.77504281
79MP0010368_abnormal_lymphatic_system0.77317741
80MP0002078_abnormal_glucose_homeostasis0.77191385
81MP0001853_heart_inflammation0.76603403
82MP0001727_abnormal_embryo_implantation0.76507381
83MP0005376_homeostasis/metabolism_phenot0.76278252
84MP0003866_abnormal_defecation0.75117546
85MP0005535_abnormal_body_temperature0.74349614
86MP0005220_abnormal_exocrine_pancreas0.73994772
87MP0000920_abnormal_myelination0.73512203
88MP0009765_abnormal_xenobiotic_induced0.73505635
89MP0001765_abnormal_ion_homeostasis0.73237533
90MP0001661_extended_life_span0.71554615
91MP0002971_abnormal_brown_adipose0.69572141
92MP0000678_abnormal_parathyroid_gland0.68517474
93MP0002090_abnormal_vision0.66745954
94MP0003448_altered_tumor_morphology0.66451799
95MP0005257_abnormal_intraocular_pressure0.64719104
96MP0005164_abnormal_response_to0.63504049
97MP0003453_abnormal_keratinocyte_physiol0.62606087
98MP0005334_abnormal_fat_pad0.62248950
99MP0003329_amyloid_beta_deposits0.61775886
100MP0002928_abnormal_bile_duct0.61730527
101MP0005266_abnormal_metabolism0.60041334
102MP0004130_abnormal_muscle_cell0.59795603
103MP0006035_abnormal_mitochondrial_morpho0.59050157
104MP0009053_abnormal_anal_canal0.56005018
105MP0003690_abnormal_glial_cell0.55321928
106MP0005395_other_phenotype0.54233035
107MP0003638_abnormal_response/metabolism_0.51767630
108MP0005666_abnormal_adipose_tissue0.49365090
109MP0000639_abnormal_adrenal_gland0.48802255
110MP0005058_abnormal_lysosome_morphology0.48484983
111MP0005410_abnormal_fertilization0.46585046
112MP0005448_abnormal_energy_balance0.45935426
113MP0000230_abnormal_systemic_arterial0.45257305
114MP0002168_other_aberrant_phenotype0.45075871
115MP0005464_abnormal_platelet_physiology0.44959366
116MP0003953_abnormal_hormone_level0.43880635
117MP0003724_increased_susceptibility_to0.41151526
118MP0008874_decreased_physiological_sensi0.41025181
119MP0008873_increased_physiological_sensi0.40827028
120MP0003718_maternal_effect0.40071734
121MP0002796_impaired_skin_barrier0.39194886
122MP0009672_abnormal_birth_weight0.37354008
123MP0008872_abnormal_physiological_respon0.36644293
124MP0004782_abnormal_surfactant_physiolog0.36425386
125MP0002135_abnormal_kidney_morphology0.36192297
126MP0003075_altered_response_to0.36053807
127MP0002837_dystrophic_cardiac_calcinosis0.35026273
128MP0002822_catalepsy0.34452051
129MP0000538_abnormal_urinary_bladder0.34048483
130MP0005166_decreased_susceptibility_to0.33608094
131MP0009115_abnormal_fat_cell0.32319741
132MP0003436_decreased_susceptibility_to0.31383164
133MP0004264_abnormal_extraembryonic_tissu0.30655222
134MP0001845_abnormal_inflammatory_respons0.29253190
135MP0003300_gastrointestinal_ulcer0.28992459
136MP0002970_abnormal_white_adipose0.28042643
137MP0000579_abnormal_nail_morphology0.26144561
138MP0000249_abnormal_blood_vessel0.25978040
139MP0006082_CNS_inflammation0.25298368
140MP0003959_abnormal_lean_body0.24507810
141MP0008961_abnormal_basal_metabolism0.23158803
142MP0009384_cardiac_valve_regurgitation0.22856196

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)7.16493210
2Intrahepatic cholestasis (HP:0001406)6.73914320
3Deep venous thrombosis (HP:0002625)6.68744338
4Abnormality of liposaccharide metabolism (HP:0010968)6.56301424
5Abnormality of glycosphingolipid metabolism (HP:0004343)6.56301424
6Abnormality of glycolipid metabolism (HP:0010969)6.56301424
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.30662118
8Xanthomatosis (HP:0000991)5.96166427
9Prolonged partial thromboplastin time (HP:0003645)5.84153968
10Hypobetalipoproteinemia (HP:0003563)5.75802527
11Hyperlipoproteinemia (HP:0010980)5.01094529
12Abnormality of glutamine family amino acid metabolism (HP:0010902)4.76906658
13Increased cerebral lipofuscin (HP:0011813)4.75624739
14Complement deficiency (HP:0004431)4.70834117
15Hyperammonemia (HP:0001987)4.69714938
16Hyperglycinuria (HP:0003108)4.49833465
17Hyperglycinemia (HP:0002154)4.46298603
18Joint hemorrhage (HP:0005261)4.44975423
19Abnormality of aspartate family amino acid metabolism (HP:0010899)4.39164523
20Hypolipoproteinemia (HP:0010981)4.34984392
21Abnormality of sulfur amino acid metabolism (HP:0004339)4.32635209
22Abnormality of serine family amino acid metabolism (HP:0010894)4.28315605
23Abnormality of glycine metabolism (HP:0010895)4.28315605
24* Ketosis (HP:0001946)4.27176143
25Increased neuronal autofluorescent lipopigment (HP:0002074)4.14680261
26Epidermoid cyst (HP:0200040)4.08688217
27Abnormality of methionine metabolism (HP:0010901)4.04765679
28Abnormality of the common coagulation pathway (HP:0010990)4.02453113
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95889570
30Hypoalphalipoproteinemia (HP:0003233)3.85682654
31Fat malabsorption (HP:0002630)3.80621731
32Abnormality of pyrimidine metabolism (HP:0004353)3.78976089
33Hypoglycemic coma (HP:0001325)3.75582954
34Gout (HP:0001997)3.70978067
35Vacuolated lymphocytes (HP:0001922)3.70742304
36Abnormality of macrophages (HP:0004311)3.65528084
37Abnormality of fatty-acid metabolism (HP:0004359)3.64375313
38Abnormality of nucleobase metabolism (HP:0010932)3.51614897
39Ketoacidosis (HP:0001993)3.48343593
40Eczematoid dermatitis (HP:0000976)3.45640756
41Abnormality of complement system (HP:0005339)3.40025023
42Abnormality of purine metabolism (HP:0004352)3.37934300
43Abnormality of the intrinsic pathway (HP:0010989)3.37183690
44Conjugated hyperbilirubinemia (HP:0002908)3.36678999
45Dysostosis multiplex (HP:0000943)3.34927563
46Delayed CNS myelination (HP:0002188)3.30934765
47Hypercholesterolemia (HP:0003124)3.29658878
48Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.29516578
49Hyperbilirubinemia (HP:0002904)3.21396720
50Loss of speech (HP:0002371)3.20957908
51Abnormality of polysaccharide metabolism (HP:0011012)3.16690124
52Abnormality of glycosaminoglycan metabolism (HP:0004371)3.16690124
53Abnormality of mucopolysaccharide metabolism (HP:0011020)3.16690124
54Abnormality of serum amino acid levels (HP:0003112)3.10932610
55Urinary glycosaminoglycan excretion (HP:0003541)3.09298650
56Mucopolysacchariduria (HP:0008155)3.09298650
57Purpura (HP:0000979)3.02096029
58Recurrent abscess formation (HP:0002722)2.96592299
59Hepatocellular carcinoma (HP:0001402)2.95973005
60Vascular calcification (HP:0004934)2.92378895
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.84464530
62Dicarboxylic aciduria (HP:0003215)2.84464530
63J-shaped sella turcica (HP:0002680)2.83096450
64* Metabolic acidosis (HP:0001942)2.82840321
65Steatorrhea (HP:0002570)2.81945648
66Spontaneous abortion (HP:0005268)2.75856908
67Generalized aminoaciduria (HP:0002909)2.74508902
68Axonal loss (HP:0003447)2.73484948
69Proximal tubulopathy (HP:0000114)2.73044122
70Alkalosis (HP:0001948)2.68939072
71* Lethargy (HP:0001254)2.67981597
72Nephritis (HP:0000123)2.66662407
73Increased serum ferritin (HP:0003281)2.63008786
74Hyperuricemia (HP:0002149)2.62367703
75Increased purine levels (HP:0004368)2.62367703
76Disinhibition (HP:0000734)2.61807252
77Cardiovascular calcification (HP:0011915)2.58632408
78Myocardial infarction (HP:0001658)2.56586018
79Recurrent bacterial skin infections (HP:0005406)2.55456273
80Malnutrition (HP:0004395)2.54143775
81Hypophosphatemia (HP:0002148)2.50509821
82Cerebral edema (HP:0002181)2.49510986
83Hypochromic microcytic anemia (HP:0004840)2.48775314
84Systemic lupus erythematosus (HP:0002725)2.48733972
85Thin bony cortex (HP:0002753)2.45872411
86Spastic diplegia (HP:0001264)2.45229105
87Skin nodule (HP:0200036)2.44751943
88Widely patent fontanelles and sutures (HP:0004492)2.44239737
89Neonatal onset (HP:0003623)2.43756930
90Enlarged kidneys (HP:0000105)2.42967320
91Protuberant abdomen (HP:0001538)2.42668356
92Vomiting (HP:0002013)2.34684288
93Nausea (HP:0002018)2.34223530
94* Irritability (HP:0000737)2.32908233
95Prolonged neonatal jaundice (HP:0006579)2.30696113
96Hypoglycemic seizures (HP:0002173)2.30269725
97Abnormality of iron homeostasis (HP:0011031)2.27855225
98Hydroxyprolinuria (HP:0003080)2.26338555
99Abnormality of proline metabolism (HP:0010907)2.26338555
100Rickets (HP:0002748)2.25910824
101Acanthocytosis (HP:0001927)2.24962254
102Cholecystitis (HP:0001082)2.24932108
103Abnormal gallbladder physiology (HP:0012438)2.24932108
104Late onset (HP:0003584)2.24749900
105Glycosuria (HP:0003076)2.24628043
106Abnormality of urine glucose concentration (HP:0011016)2.24628043
107Neurofibrillary tangles (HP:0002185)2.23624183
108Sensorimotor neuropathy (HP:0007141)2.23123835
109Mitral stenosis (HP:0001718)2.21735757
110Pancreatitis (HP:0001733)2.21556030
111Glomerulonephritis (HP:0000099)2.20207315
112Retinal atrophy (HP:0001105)2.20035811
113Abdominal distention (HP:0003270)2.19141762
114Abnormal gallbladder morphology (HP:0012437)2.18982645
115Bone pain (HP:0002653)2.18507278
116Abnormality of the periventricular white matter (HP:0002518)2.16351791
117Cholelithiasis (HP:0001081)2.14760284
118Metaphyseal irregularity (HP:0003025)2.09184107
119Pathologic fracture (HP:0002756)2.07977472
120Abnormal enzyme/coenzyme activity (HP:0012379)2.07695043
121Diminished motivation (HP:0000745)2.04985248
122Brushfield spots (HP:0001088)2.04961371
123Esophageal varix (HP:0002040)2.03648396
124Amyloidosis (HP:0011034)2.02287704
125Recurrent gram-negative bacterial infections (HP:0005420)2.02238392
126Gingivitis (HP:0000230)2.00715824
127Thrombophlebitis (HP:0004418)2.00687975
128Progressive neurologic deterioration (HP:0002344)1.98226194
129Neuronal loss in central nervous system (HP:0002529)1.96828122
130Apathy (HP:0000741)1.96570717
131Elevated alkaline phosphatase (HP:0003155)1.96216385
132Cardiomegaly (HP:0001640)1.95388648
133Menorrhagia (HP:0000132)1.95093946
134Opisthotonus (HP:0002179)1.94119415
135Hypophosphatemic rickets (HP:0004912)1.92831343
136Mutism (HP:0002300)1.92003568
137Hemorrhage of the eye (HP:0011885)1.91144063
138Chronic obstructive pulmonary disease (HP:0006510)1.91089862
139Obstructive lung disease (HP:0006536)1.91089862
140Gingival bleeding (HP:0000225)1.90550098
141Hyperinsulinemic hypoglycemia (HP:0000825)1.90447060
142Nephrolithiasis (HP:0000787)1.89787980
143Abnormality of transition element cation homeostasis (HP:0011030)1.89368496
144Interstitial pulmonary disease (HP:0006530)1.87893353
145Pulmonary embolism (HP:0002204)1.87616957
146Petechiae (HP:0000967)1.86868404
147Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86781355
148Abnormality of the gallbladder (HP:0005264)1.86193491
149Abnormal cartilage morphology (HP:0002763)1.85627443
150Abnormality of alkaline phosphatase activity (HP:0004379)1.84434318
151Confusion (HP:0001289)1.83714555
152Renal cortical cysts (HP:0000803)1.81944679
153Autoimmune thrombocytopenia (HP:0001973)1.81892985
154Peripheral demyelination (HP:0011096)1.80766444
155Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.78086192
156Hepatosplenomegaly (HP:0001433)1.77957396
157Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76757232
158Thoracic kyphosis (HP:0002942)1.76624534
159Multiple lipomas (HP:0001012)1.75799378
160Asymmetric septal hypertrophy (HP:0001670)1.74499551
161Cerebral inclusion bodies (HP:0100314)1.68913878

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK7.29519373
2FGFR44.22025859
3ERN13.88806922
4SIK13.72215783
5BLK2.87816783
6RIPK42.83660129
7WNK42.80788102
8WNK32.64477780
9INSRR2.62110714
10TAOK32.56091613
11ERBB42.48569585
12TESK22.45560691
13ACVR1B2.39471558
14PDK32.28586452
15PDK42.28586452
16MST1R2.15846691
17NME21.98203502
18MAP2K41.95360762
19PRPF4B1.87056715
20OXSR11.84235149
21PKN21.80011098
22MAPK111.77516930
23EPHA21.71993678
24MAP4K11.69250049
25STK38L1.68649879
26PIK3CG1.66316064
27TRIB31.60486589
28TESK11.59691515
29FLT31.54317522
30ZAP701.48949181
31MAPKAPK31.44528138
32LATS11.41996239
33PRKG21.40979670
34PINK11.40947983
35GRK71.37806234
36TYK21.36893799
37ABL21.35947887
38FRK1.35895074
39PTK61.35373948
40PDK21.33998163
41SCYL21.30076906
42TAOK11.27215778
43DAPK21.22743655
44NEK91.19276441
45FGR1.19032876
46RPS6KA21.18851946
47MAPK151.18014511
48GRK61.15315427
49KDR1.11961245
50MAP3K71.06942201
51PRKAA21.06439612
52MATK1.06383445
53MAP2K21.05013625
54IRAK41.04969625
55SMG11.03977143
56PAK41.03932433
57JAK21.03549420
58DYRK1B1.01293881
59NEK60.99780434
60MAP3K120.99281812
61MAP2K30.98089829
62CDC42BPA0.97982726
63EPHB10.97832295
64FGFR20.97212917
65PIK3CA0.96886313
66MAP3K130.93845147
67STK390.93656419
68IKBKB0.92954934
69MAP3K30.92269339
70MAP3K20.88747492
71PRKCZ0.87139758
72TIE10.86132197
73ICK0.85762016
74TBK10.84422840
75LIMK10.83840538
76MAPK40.83660818
77TNK20.81406765
78ERBB20.80375619
79SGK4940.78631304
80SGK2230.78631304
81MAP3K100.78620581
82SGK30.78036227
83GSK3A0.76635458
84PRKAA10.76471719
85RPS6KC10.76290611
86RPS6KL10.76290611
87KSR20.75324440
88MET0.73872067
89JAK10.73528557
90MAP3K140.73436312
91MAP3K110.72576673
92MUSK0.72315033
93MAP2K60.68941623
94CHUK0.67666198
95LRRK20.66991224
96PIM20.66866810
97LYN0.65450193
98SGK20.64979553
99STK380.64891484
100MAPK120.64265972
101PDPK10.64172617
102BMPR20.64043169
103ARAF0.63226039
104MAPKAPK20.62559020
105DDR20.62512842
106CSK0.62469893
107* PRKACG0.60400378
108CDK60.59986478
109PTK20.59591978
110TGFBR20.59464229
111RPS6KA60.58327353
112HCK0.54857987
113SYK0.54588475
114CAMK2G0.53736653
115NEK10.53417022
116RIPK10.52898061
117SIK30.52309008
118PDK10.52036124
119JAK30.51300716
120EPHA30.51051240
121FES0.50662651
122RPS6KB20.47929041
123BTK0.47328472
124FER0.46701400
125IRAK30.45512968
126LCK0.45435072
127CAMKK10.45270952
128CSF1R0.42712633
129PRKCQ0.42027615
130IRAK10.40510670
131MAPK70.37815114
132CAMK1D0.36558468
133PRKCG0.35917791
134MTOR0.35617009
135IGF1R0.35223332
136IKBKE0.35075015
137FGFR30.34238796
138MAP3K50.33584031
139PTK2B0.32870863
140GRK10.31838260
141IRAK20.30474703
142CDK40.29025015
143CSNK1G10.28504074
144MAP3K60.28190290
145MAP2K10.24726865
146EGFR0.24400150
147TAOK20.24031153
148EPHA40.23723983
149RET0.22709667
150STK30.22116282
151* PRKCA0.20327411
152CAMK40.19284873
153MAP3K10.19112988
154PBK0.15780559

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.19237323
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44396974
3Nitrogen metabolism_Homo sapiens_hsa009103.37130521
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.31342064
5Arginine biosynthesis_Homo sapiens_hsa002202.93863366
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.77863210
7Tryptophan metabolism_Homo sapiens_hsa003802.69722856
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.62983699
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.56261725
10Fatty acid degradation_Homo sapiens_hsa000712.56096603
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51736250
12Complement and coagulation cascades_Homo sapiens_hsa046102.46929139
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42322655
14Butanoate metabolism_Homo sapiens_hsa006502.36830947
15Peroxisome_Homo sapiens_hsa041462.20254279
16Propanoate metabolism_Homo sapiens_hsa006402.19049021
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07003620
18PPAR signaling pathway_Homo sapiens_hsa033201.87986464
19Fatty acid metabolism_Homo sapiens_hsa012121.87287782
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87076614
21Chemical carcinogenesis_Homo sapiens_hsa052041.86658830
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.84193469
23Histidine metabolism_Homo sapiens_hsa003401.83088892
24Steroid hormone biosynthesis_Homo sapiens_hsa001401.82459237
25beta-Alanine metabolism_Homo sapiens_hsa004101.76301567
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.69811497
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.68616673
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.68147724
29Selenocompound metabolism_Homo sapiens_hsa004501.64186822
30Pyruvate metabolism_Homo sapiens_hsa006201.62945929
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61775160
32Retinol metabolism_Homo sapiens_hsa008301.59807409
33Caffeine metabolism_Homo sapiens_hsa002321.56715417
34Bile secretion_Homo sapiens_hsa049761.53806937
35Phenylalanine metabolism_Homo sapiens_hsa003601.51920125
36Staphylococcus aureus infection_Homo sapiens_hsa051501.51185332
37Sulfur metabolism_Homo sapiens_hsa009201.43296770
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.35436350
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.35269473
40Tyrosine metabolism_Homo sapiens_hsa003501.31869785
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31472077
42Starch and sucrose metabolism_Homo sapiens_hsa005001.30085592
43Fatty acid elongation_Homo sapiens_hsa000621.28310488
44Biosynthesis of amino acids_Homo sapiens_hsa012301.25374757
45Asthma_Homo sapiens_hsa053101.22860055
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.22694715
47Folate biosynthesis_Homo sapiens_hsa007901.20839546
48* Carbon metabolism_Homo sapiens_hsa012001.20751125
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15257644
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.13363067
51Rheumatoid arthritis_Homo sapiens_hsa053231.12564802
52ABC transporters_Homo sapiens_hsa020101.12043251
53Leishmaniasis_Homo sapiens_hsa051401.09000367
54Fat digestion and absorption_Homo sapiens_hsa049751.07242985
55Steroid biosynthesis_Homo sapiens_hsa001001.07010810
56Vitamin digestion and absorption_Homo sapiens_hsa049771.05364308
57Arginine and proline metabolism_Homo sapiens_hsa003301.04997307
58Pertussis_Homo sapiens_hsa051331.04927768
59Phagosome_Homo sapiens_hsa041451.04907187
60Allograft rejection_Homo sapiens_hsa053301.04148210
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.99915415
62Tuberculosis_Homo sapiens_hsa051520.95461576
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92167087
64Vitamin B6 metabolism_Homo sapiens_hsa007500.91671753
65Osteoclast differentiation_Homo sapiens_hsa043800.91355256
66Graft-versus-host disease_Homo sapiens_hsa053320.89873189
67Sulfur relay system_Homo sapiens_hsa041220.89794274
68Autoimmune thyroid disease_Homo sapiens_hsa053200.89666592
69Lysine degradation_Homo sapiens_hsa003100.88334392
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85724684
71Glutathione metabolism_Homo sapiens_hsa004800.82915356
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.79444444
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.77908662
74* Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77340271
75Glycerolipid metabolism_Homo sapiens_hsa005610.76240706
76Collecting duct acid secretion_Homo sapiens_hsa049660.73671696
77One carbon pool by folate_Homo sapiens_hsa006700.66483426
78Antigen processing and presentation_Homo sapiens_hsa046120.64645796
79Sphingolipid metabolism_Homo sapiens_hsa006000.63807833
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.61850435
81Type I diabetes mellitus_Homo sapiens_hsa049400.59170840
82Vibrio cholerae infection_Homo sapiens_hsa051100.56452207
83Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52967722
84* Metabolic pathways_Homo sapiens_hsa011000.49770722
85Fatty acid biosynthesis_Homo sapiens_hsa000610.47890599
86* Pentose phosphate pathway_Homo sapiens_hsa000300.41036985
87Hematopoietic cell lineage_Homo sapiens_hsa046400.40069368
88Viral myocarditis_Homo sapiens_hsa054160.38455770
89Toxoplasmosis_Homo sapiens_hsa051450.36492265
90B cell receptor signaling pathway_Homo sapiens_hsa046620.33637771
91Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32261111
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31173101
93alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30753543
94Legionellosis_Homo sapiens_hsa051340.29596353
95Amoebiasis_Homo sapiens_hsa051460.28051269
96Influenza A_Homo sapiens_hsa051640.27414847
97Galactose metabolism_Homo sapiens_hsa000520.25700092
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.25292384
99Chemokine signaling pathway_Homo sapiens_hsa040620.24869170
100TNF signaling pathway_Homo sapiens_hsa046680.23510701
101Linoleic acid metabolism_Homo sapiens_hsa005910.22158443
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.21315072
103Insulin resistance_Homo sapiens_hsa049310.21041843
104Prion diseases_Homo sapiens_hsa050200.20279150
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16981393
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.14829469
107* Fructose and mannose metabolism_Homo sapiens_hsa000510.14217539
108* Glucagon signaling pathway_Homo sapiens_hsa049220.07516455
109Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2149161
110Lysosome_Homo sapiens_hsa04142-0.2054503
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2038500
112Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1923733
113Hepatitis C_Homo sapiens_hsa05160-0.1884903
114* Insulin signaling pathway_Homo sapiens_hsa04910-0.1880643
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1776859
116Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1759564
117Other glycan degradation_Homo sapiens_hsa00511-0.1757904
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1626686
119Regulation of autophagy_Homo sapiens_hsa04140-0.1348774
120Protein digestion and absorption_Homo sapiens_hsa04974-0.1153447
121Mineral absorption_Homo sapiens_hsa04978-0.1049010
122Ovarian steroidogenesis_Homo sapiens_hsa04913-0.1037250
123Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1006832
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0870450
125Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0662612
126Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0625794
127Renin-angiotensin system_Homo sapiens_hsa04614-0.0509100
128* AMPK signaling pathway_Homo sapiens_hsa04152-0.0306056
129Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0291523
130Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0187852

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