FBRS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.85640170
2negative regulation of cell killing (GO:0031342)4.66780960
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.66780960
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.49528603
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.49528603
6antigen processing and presentation of endogenous antigen (GO:0019883)4.30287763
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29994681
8positive regulation by organism of defense response of other organism involved in symbiotic interact4.29994681
9modulation by symbiont of host immune response (GO:0052553)4.29994681
10positive regulation by symbiont of host defense response (GO:0052509)4.29994681
11modulation by symbiont of host defense response (GO:0052031)4.29994681
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29994681
13positive regulation of histone deacetylation (GO:0031065)4.17952359
14regulation of gamma-delta T cell differentiation (GO:0045586)4.14569484
15positive thymic T cell selection (GO:0045059)4.07371054
16regulation of gamma-delta T cell activation (GO:0046643)3.94368038
17regulation of interleukin-12 biosynthetic process (GO:0045075)3.67509405
18regulation of interferon-beta biosynthetic process (GO:0045357)3.57582122
19germinal center formation (GO:0002467)3.57215018
20tolerance induction (GO:0002507)3.48707788
21detection of other organism (GO:0098543)3.47974099
22detection of bacterium (GO:0016045)3.47553831
23negative regulation of erythrocyte differentiation (GO:0045647)3.45176172
24leukocyte aggregation (GO:0070486)3.41755058
25NIK/NF-kappaB signaling (GO:0038061)3.34979766
26positive regulation of B cell differentiation (GO:0045579)3.34571374
27JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.34075271
28thymic T cell selection (GO:0045061)3.32088771
29negative regulation of interleukin-12 production (GO:0032695)3.28535968
30mannose metabolic process (GO:0006013)3.26956852
31regulation of T-helper 2 cell differentiation (GO:0045628)3.20402894
32macrophage activation involved in immune response (GO:0002281)3.19471923
33positive T cell selection (GO:0043368)3.19402006
34B cell receptor signaling pathway (GO:0050853)3.12545722
35T cell selection (GO:0045058)3.11963244
36regulation of B cell receptor signaling pathway (GO:0050855)3.08561464
37response to laminar fluid shear stress (GO:0034616)3.07343497
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.05071505
39regulation of B cell differentiation (GO:0045577)3.04993748
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93229818
41response to muramyl dipeptide (GO:0032495)2.91187198
42detection of external biotic stimulus (GO:0098581)2.90775240
43positive regulation of protein deacetylation (GO:0090312)2.87363367
44regulation of leukocyte degranulation (GO:0043300)2.86300730
45negative T cell selection (GO:0043383)2.85475414
46negative thymic T cell selection (GO:0045060)2.85249929
47regulation of mast cell degranulation (GO:0043304)2.83937484
48cellular extravasation (GO:0045123)2.78264707
49modulation by symbiont of host cellular process (GO:0044068)2.76638988
50positive regulation of Cdc42 GTPase activity (GO:0043089)2.75519160
51natural killer cell differentiation (GO:0001779)2.75094240
52immunoglobulin mediated immune response (GO:0016064)2.74114731
53modulation by virus of host process (GO:0019054)2.73740841
54regulation of histone H3-K27 methylation (GO:0061085)2.71738351
55neutrophil activation (GO:0042119)2.71064017
56granulocyte activation (GO:0036230)2.70981698
57negative regulation of granulocyte differentiation (GO:0030853)2.69301103
58regulation of erythrocyte differentiation (GO:0045646)2.69095338
59regulation of myeloid leukocyte mediated immunity (GO:0002886)2.68062855
60cellular response to zinc ion (GO:0071294)2.67788231
61antigen processing and presentation via MHC class Ib (GO:0002475)2.66725041
62response to peptidoglycan (GO:0032494)2.66567071
63leukocyte cell-cell adhesion (GO:0007159)2.65946553
64negative regulation of phagocytosis (GO:0050765)2.64086177
65growth hormone receptor signaling pathway (GO:0060396)2.63930869
66neutrophil activation involved in immune response (GO:0002283)2.62073903
67positive regulation of interferon-alpha production (GO:0032727)2.61410263
68histone H3-K36 demethylation (GO:0070544)2.60126172
69detection of molecule of bacterial origin (GO:0032490)2.59372402
70negative regulation of lymphocyte mediated immunity (GO:0002707)2.59289313
71regulation of type I interferon-mediated signaling pathway (GO:0060338)2.58078490
72negative regulation of leukocyte mediated immunity (GO:0002704)2.57529013
73detection of biotic stimulus (GO:0009595)2.57166976
74negative regulation of stress fiber assembly (GO:0051497)2.54958692
75myeloid dendritic cell differentiation (GO:0043011)2.54555657
76response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54520031
77response to host immune response (GO:0052572)2.54520031
78regulation of dendritic cell antigen processing and presentation (GO:0002604)2.53209174
79mature B cell differentiation (GO:0002335)2.53200192
80cytoplasmic mRNA processing body assembly (GO:0033962)2.52031071
81regulation of interferon-alpha production (GO:0032647)2.51983248
82positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.50648135
83response to type I interferon (GO:0034340)2.49666238
84response to host (GO:0075136)2.49361472
85response to host defenses (GO:0052200)2.49361472
86response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.49361472
87regulation of necroptotic process (GO:0060544)2.49267466
88protein localization to endosome (GO:0036010)2.48763647
89negative regulation of toll-like receptor signaling pathway (GO:0034122)2.48372484
90regulation of T cell tolerance induction (GO:0002664)2.48109443
91regulation of mast cell activation involved in immune response (GO:0033006)2.47510513
92positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.47301095
93negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.47007230
94negative regulation of interleukin-6 production (GO:0032715)2.46205765
95signal complex assembly (GO:0007172)2.44190965
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44041490
97regulation of tolerance induction (GO:0002643)2.43111296
98positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.42937792
99T cell migration (GO:0072678)2.42797230
100positive regulation of type 2 immune response (GO:0002830)2.42570965
101megakaryocyte development (GO:0035855)2.42406502
102activation of JUN kinase activity (GO:0007257)2.42144179
103defense response to protozoan (GO:0042832)2.41634253
104regulation of NFAT protein import into nucleus (GO:0051532)2.41578617
105embryonic process involved in female pregnancy (GO:0060136)2.41399849
106cortical actin cytoskeleton organization (GO:0030866)2.40961795
107regulation of integrin activation (GO:0033623)2.40634497
108I-kappaB phosphorylation (GO:0007252)2.40611944
109positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.40010982
110regulation of ARF GTPase activity (GO:0032312)2.39087771
111interferon-gamma-mediated signaling pathway (GO:0060333)2.37014756
112cellular response to growth hormone stimulus (GO:0071378)2.36715556
113cellular response to type I interferon (GO:0071357)2.36432164
114type I interferon signaling pathway (GO:0060337)2.36432164
115response to protozoan (GO:0001562)2.35515639
116antigen receptor-mediated signaling pathway (GO:0050851)2.35454201
117negative regulation of T cell mediated immunity (GO:0002710)2.35407453
118histone H3-K4 trimethylation (GO:0080182)2.35251460
119stress fiber assembly (GO:0043149)2.34991311
120response to interleukin-15 (GO:0070672)2.34291033
121CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.34221597
122myeloid cell activation involved in immune response (GO:0002275)2.33262949
123regulation of histone deacetylation (GO:0031063)2.32717269
124B cell homeostasis (GO:0001782)2.32693733
125lipopolysaccharide-mediated signaling pathway (GO:0031663)2.31303720
126positive regulation of tolerance induction (GO:0002645)2.30910816
127myeloid dendritic cell activation (GO:0001773)2.30603246
128negative regulation of cytokine production involved in immune response (GO:0002719)2.30447999
129interferon-gamma production (GO:0032609)2.29392960
130respiratory burst (GO:0045730)2.29220491
131germ cell migration (GO:0008354)2.28845758
132regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.28737314
133intracellular estrogen receptor signaling pathway (GO:0030520)2.28036873
1343-UTR-mediated mRNA stabilization (GO:0070935)2.27363696
135negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.26906820

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.59519144
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.55557743
3MYC_22102868_ChIP-Seq_BL_Human3.51630287
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.51486842
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.22009781
6VDR_21846776_ChIP-Seq_THP-1_Human3.19757104
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.08940965
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.93558474
9* TCF7_22412390_ChIP-Seq_EML_Mouse2.77440799
10SCL_19346495_ChIP-Seq_HPC-7_Human2.61496034
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.58915719
12* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.58868087
13* KDM2B_26808549_Chip-Seq_DND41_Human2.54233979
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.52265257
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.51816191
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.41372328
17MAF_26560356_Chip-Seq_TH1_Human2.39345210
18* KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.37224100
19* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.34573781
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32637123
21VDR_24763502_ChIP-Seq_THP-1_Human2.31912291
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.21079462
23* ELK3_25401928_ChIP-Seq_HUVEC_Human2.20296237
24UTX_26944678_Chip-Seq_JUKART_Human2.19788372
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13428249
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.09148133
27FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05854837
28RUNX_20019798_ChIP-Seq_JUKART_Human2.03580424
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.01563748
30STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95249250
31THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.92586855
32SPI1_23127762_ChIP-Seq_K562_Human1.90408712
33LXR_22292898_ChIP-Seq_THP-1_Human1.88624312
34IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87598808
35VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85158141
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.81284752
37* MYB_26560356_Chip-Seq_TH2_Human1.79997964
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.78347151
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.77246740
40* MYB_26560356_Chip-Seq_TH1_Human1.75348543
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.71916843
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67082161
43IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.65953655
44* KDM2B_26808549_Chip-Seq_JURKAT_Human1.65907402
45* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.60241151
46STAT6_21828071_ChIP-Seq_BEAS2B_Human1.57495339
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56496955
48MAF_26560356_Chip-Seq_TH2_Human1.55974434
49TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55378285
50GATA1_19941826_ChIP-Seq_K562_Human1.52979199
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50543374
52* P68_20966046_ChIP-Seq_HELA_Human1.50399402
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.48741207
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.46962828
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.45148015
56* KDM2B_26808549_Chip-Seq_K562_Human1.44478010
57RACK7_27058665_Chip-Seq_MCF-7_Human1.43616040
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40058574
59SMC4_20622854_ChIP-Seq_HELA_Human1.35302242
60* NCOR1_26117541_ChIP-Seq_K562_Human1.33879899
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33045702
62BCOR_27268052_Chip-Seq_Bcells_Human1.31645128
63SPI1_23547873_ChIP-Seq_NB4_Human1.30335484
64PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29022096
65P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27992890
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26803763
67GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25852029
68NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.25396267
69EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24384901
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.22418408
71* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22110731
72* BCL6_27268052_Chip-Seq_Bcells_Human1.20311155
73GATA3_27048872_Chip-Seq_THYMUS_Human1.19975141
74TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.19154715
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18961187
76KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18795349
77GATA2_19941826_ChIP-Seq_K562_Human1.18513674
78PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17639867
79GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17468113
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17055308
81* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16654594
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16040296
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12562373
84PU_27001747_Chip-Seq_BMDM_Mouse1.12030537
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11008451
86PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10301683
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10064779
88VDR_24787735_ChIP-Seq_THP-1_Human1.08371897
89DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08324441
90PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05831045
91CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05506867
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04761573
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04376174
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.02620516
95GATA2_21666600_ChIP-Seq_HMVEC_Human1.02143010
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00359713
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00088284
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.99350443
99FOXM1_23109430_ChIP-Seq_U2OS_Human0.98277460
100NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97840907
101SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97160530
102DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95978418
103ESR2_21235772_ChIP-Seq_MCF-7_Human0.95831421
104RUNX1_27514584_Chip-Seq_MCF-7_Human0.95322813
105SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95213328
106EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95129808
107EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94453891
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93213968
109* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93102029
110TP63_22573176_ChIP-Seq_HFKS_Human0.92759037
111ATF3_27146783_Chip-Seq_COLON_Human0.92346268
112RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92114328
113CTCF_21964334_ChIP-Seq_BJAB-B_Human0.91860397
114CREB1_26743006_Chip-Seq_LNCaP_Human0.91699592
115PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.91488819
116WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90809809
117GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90338566
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89991674
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.88903360
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88796743
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88267184
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.87703471

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.88431974
2MP0009278_abnormal_bone_marrow3.24364189
3MP0003300_gastrointestinal_ulcer3.17079324
4MP0001790_abnormal_immune_system2.88904518
5MP0005387_immune_system_phenotype2.88904518
6MP0003436_decreased_susceptibility_to2.88900499
7MP0000685_abnormal_immune_system2.84253483
8MP0001835_abnormal_antigen_presentation2.83641131
9MP0005451_abnormal_body_composition2.62700587
10MP0001800_abnormal_humoral_immune2.58347976
11MP0004510_myositis2.55364315
12MP0005076_abnormal_cell_differentiation2.29023810
13MP0005000_abnormal_immune_tolerance2.27232859
14MP0002452_abnormal_antigen_presenting2.26696746
15MP0001545_abnormal_hematopoietic_system2.23802510
16MP0005397_hematopoietic_system_phenotyp2.23802510
17MP0004947_skin_inflammation2.22909700
18MP0002723_abnormal_immune_serum2.10709380
19MP0003705_abnormal_hypodermis_morpholog2.10670910
20MP0002420_abnormal_adaptive_immunity2.03598317
21MP0001819_abnormal_immune_cell2.02652404
22MP0002419_abnormal_innate_immunity2.01537198
23MP0005025_abnormal_response_to2.00769648
24MP0005671_abnormal_response_to1.97264750
25MP0002398_abnormal_bone_marrow1.96548981
26MP0003763_abnormal_thymus_physiology1.94758282
27MP0006082_CNS_inflammation1.94433663
28MP0002405_respiratory_system_inflammati1.93568029
29MP0008260_abnormal_autophagy1.93343585
30MP0005464_abnormal_platelet_physiology1.88208057
31MP0004808_abnormal_hematopoietic_stem1.86296558
32MP0002166_altered_tumor_susceptibility1.85468884
33MP0010352_gastrointestinal_tract_polyps1.76364717
34MP0000716_abnormal_immune_system1.74153416
35MP0008961_abnormal_basal_metabolism1.73204297
36MP0003172_abnormal_lysosome_physiology1.72099907
37MP0009785_altered_susceptibility_to1.68890681
38MP0002396_abnormal_hematopoietic_system1.66899315
39MP0003566_abnormal_cell_adhesion1.65879509
40MP0010155_abnormal_intestine_physiology1.62872476
41MP0005058_abnormal_lysosome_morphology1.61950370
42MP0000689_abnormal_spleen_morphology1.59089138
43MP0009333_abnormal_splenocyte_physiolog1.57498057
44MP0002722_abnormal_immune_system1.55467446
45MP0005310_abnormal_salivary_gland1.49828266
46MP0009840_abnormal_foam_cell1.49035169
47MP0000678_abnormal_parathyroid_gland1.48725859
48MP0000703_abnormal_thymus_morphology1.47538017
49MP0003453_abnormal_keratinocyte_physiol1.44905273
50MP0002429_abnormal_blood_cell1.44284087
51MP0001348_abnormal_lacrimal_gland1.44231636
52MP0001533_abnormal_skeleton_physiology1.40873474
53MP0004381_abnormal_hair_follicle1.40338507
54MP0001873_stomach_inflammation1.39609422
55MP0001845_abnormal_inflammatory_respons1.39229251
56MP0000569_abnormal_digit_pigmentation1.38973103
57MP0002148_abnormal_hypersensitivity_rea1.37286845
58MP0003191_abnormal_cellular_cholesterol1.33926620
59MP0002006_tumorigenesis1.33409861
60MP0005409_darkened_coat_color1.33401659
61MP0003448_altered_tumor_morphology1.31416998
62MP0003045_fibrosis1.29466811
63MP0003866_abnormal_defecation1.29344031
64MP0002132_abnormal_respiratory_system1.28852835
65MP0004858_abnormal_nervous_system1.27563246
66MP0000465_gastrointestinal_hemorrhage1.26426793
67MP0002933_joint_inflammation1.21917048
68MP0003183_abnormal_peptide_metabolism1.21848123
69MP0002998_abnormal_bone_remodeling1.21550329
70MP0003091_abnormal_cell_migration1.18809792
71MP0001853_heart_inflammation1.15243479
72MP0005023_abnormal_wound_healing1.14726791
73MP0004185_abnormal_adipocyte_glucose1.13709070
74MP0001851_eye_inflammation1.12609837
75MP0000858_altered_metastatic_potential1.04886434
76MP0003828_pulmonary_edema1.04117231
77MP0002796_impaired_skin_barrier1.02987302
78MP0003656_abnormal_erythrocyte_physiolo1.00527641
79MP0004264_abnormal_extraembryonic_tissu0.98226919
80MP0002254_reproductive_system_inflammat0.97215227
81MP0005174_abnormal_tail_pigmentation0.96735668
82MP0010307_abnormal_tumor_latency0.96580510
83MP0010234_abnormal_vibrissa_follicle0.96147290
84MP0000733_abnormal_muscle_development0.96124358
85MP0008469_abnormal_protein_level0.96106445
86MP0003279_aneurysm0.95194112
87MP0003075_altered_response_to0.95157434
88MP0002249_abnormal_larynx_morphology0.94345178
89MP0000343_altered_response_to0.85668530
90MP0000767_abnormal_smooth_muscle0.84178854
91MP0001849_ear_inflammation0.82167701
92MP0009764_decreased_sensitivity_to0.81072462
93MP0009931_abnormal_skin_appearance0.80327258
94MP0010630_abnormal_cardiac_muscle0.79563753
95MP0002138_abnormal_hepatobiliary_system0.78410456
96MP0008004_abnormal_stomach_pH0.77035962
97MP0005390_skeleton_phenotype0.74044257
98MP0000681_abnormal_thyroid_gland0.73478103
99MP0001216_abnormal_epidermal_layer0.73394309
100MP0000490_abnormal_crypts_of0.73045872
101MP0001663_abnormal_digestive_system0.71467897
102MP0003724_increased_susceptibility_to0.71249984
103MP0005375_adipose_tissue_phenotype0.70512990
104MP0009115_abnormal_fat_cell0.69864911
105MP0000604_amyloidosis0.68313828
106MP0002925_abnormal_cardiovascular_devel0.68246970
107MP0000249_abnormal_blood_vessel0.66810369
108MP0000609_abnormal_liver_physiology0.66717091
109MP0002019_abnormal_tumor_incidence0.66309778
110MP0002928_abnormal_bile_duct0.65854287
111MP0002877_abnormal_melanocyte_morpholog0.65749918
112MP0002060_abnormal_skin_morphology0.65719239
113MP0005166_decreased_susceptibility_to0.64416745
114MP0003795_abnormal_bone_structure0.63249749
115MP0005666_abnormal_adipose_tissue0.62555129
116MP0005670_abnormal_white_adipose0.62354046

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.47640379
2Recurrent fungal infections (HP:0002841)3.73429621
3Autoimmune thrombocytopenia (HP:0001973)3.71827539
4Abnormality of the fingertips (HP:0001211)3.69498052
5Recurrent abscess formation (HP:0002722)3.61134430
6Recurrent viral infections (HP:0004429)3.58899440
7Cellulitis (HP:0100658)3.52295336
8Recurrent bacterial skin infections (HP:0005406)3.50701355
9Nasal polyposis (HP:0100582)3.28234468
10Cerebral aneurysm (HP:0004944)3.21076916
11Colitis (HP:0002583)3.19903490
12Pustule (HP:0200039)3.11984595
13Inflammation of the large intestine (HP:0002037)3.11230332
14Gastrointestinal inflammation (HP:0004386)3.08108214
15Increased IgE level (HP:0003212)3.07452099
16Chronic otitis media (HP:0000389)3.06318444
17Abnormality of the nasal mucosa (HP:0000433)3.04583321
18Obstructive sleep apnea (HP:0002870)3.04204672
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.98635752
20Elevated erythrocyte sedimentation rate (HP:0003565)2.89383085
21Mediastinal lymphadenopathy (HP:0100721)2.85696847
22Gastrointestinal infarctions (HP:0005244)2.71433250
23T lymphocytopenia (HP:0005403)2.65779188
24Spontaneous hematomas (HP:0007420)2.65422224
25Panhypogammaglobulinemia (HP:0003139)2.63783987
26Recurrent gram-negative bacterial infections (HP:0005420)2.62509873
27Broad face (HP:0000283)2.62324426
28Chronic mucocutaneous candidiasis (HP:0002728)2.62155122
29Recurrent cutaneous fungal infections (HP:0011370)2.62155122
30Abnormality of T cell number (HP:0011839)2.58342397
31Recurrent skin infections (HP:0001581)2.57693069
32Papilloma (HP:0012740)2.57090372
33Verrucae (HP:0200043)2.57090372
34Stomatitis (HP:0010280)2.44568514
35Hematochezia (HP:0002573)2.43910264
36Meningitis (HP:0001287)2.43525712
37Obstructive lung disease (HP:0006536)2.42000232
38Chronic obstructive pulmonary disease (HP:0006510)2.42000232
39Gingivitis (HP:0000230)2.41912551
40Agammaglobulinemia (HP:0004432)2.40203199
41Increased density of long bones (HP:0006392)2.39985909
42Recurrent bronchitis (HP:0002837)2.39969937
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.38584483
44Thin bony cortex (HP:0002753)2.37851933
45Interstitial pulmonary disease (HP:0006530)2.36453697
46Segmental peripheral demyelination/remyelination (HP:0003481)2.35914654
47Emphysema (HP:0002097)2.35857680
48Vasculitis (HP:0002633)2.34956051
49Hyperacusis (HP:0010780)2.34287973
50Polycythemia (HP:0001901)2.33962276
51Retrobulbar optic neuritis (HP:0100654)2.32606269
52Optic neuritis (HP:0100653)2.32606269
53Myositis (HP:0100614)2.31277458
54Ulnar bowing (HP:0003031)2.27943574
55Myocardial infarction (HP:0001658)2.25094110
56Periodontitis (HP:0000704)2.22696422
57Leukocytosis (HP:0001974)2.18974027
58Prolonged bleeding time (HP:0003010)2.16180235
59Abnormality of macrophages (HP:0004311)2.15316335
60Disproportionate tall stature (HP:0001519)2.14993733
61Urticaria (HP:0001025)2.09826479
62Abnormality of T cells (HP:0002843)2.08908223
63Hemorrhage of the eye (HP:0011885)2.08133156
64Eosinophilia (HP:0001880)2.07623792
65Slow saccadic eye movements (HP:0000514)2.07072455
66Osteomyelitis (HP:0002754)2.03340184
67Macroorchidism (HP:0000053)2.02390180
68Distal lower limb amyotrophy (HP:0008944)2.02386953
69Purpura (HP:0000979)2.01726026
70Aortic aneurysm (HP:0004942)2.01717118
71Chest pain (HP:0100749)2.01205401
72Increased cerebral lipofuscin (HP:0011813)2.00758024
73Gingival bleeding (HP:0000225)2.00013794
74Gastrointestinal stroma tumor (HP:0100723)1.99923272
75Polygenic inheritance (HP:0010982)1.95844402
76Frequent falls (HP:0002359)1.94702552
77Asymmetric septal hypertrophy (HP:0001670)1.94658145
78Fatigue (HP:0012378)1.93823129
79Restrictive lung disease (HP:0002091)1.93554004
80Peritonitis (HP:0002586)1.93523087
81Hypertensive crisis (HP:0100735)1.91686619
82Thyroiditis (HP:0100646)1.91364258
83IgM deficiency (HP:0002850)1.90175849
84Abnormality of liposaccharide metabolism (HP:0010968)1.85920925
85Abnormality of glycosphingolipid metabolism (HP:0004343)1.85920925
86Abnormality of glycolipid metabolism (HP:0010969)1.85920925
87Spinal cord lesions (HP:0100561)1.85383901
88Syringomyelia (HP:0003396)1.85383901
89Mitral valve prolapse (HP:0001634)1.84580049
90Flat acetabular roof (HP:0003180)1.84307579
91Urinary glycosaminoglycan excretion (HP:0003541)1.83847880
92Mucopolysacchariduria (HP:0008155)1.83847880
93Cheilitis (HP:0100825)1.83760735
94Abnormal platelet function (HP:0011869)1.83131687
95Impaired platelet aggregation (HP:0003540)1.83131687
96Osteolytic defects of the hand bones (HP:0009699)1.83081796
97Osteolytic defects of the phalanges of the hand (HP:0009771)1.83081796
98Easy fatigability (HP:0003388)1.82957924
99Loss of speech (HP:0002371)1.80938589
100Petechiae (HP:0000967)1.80839097
101Long palpebral fissure (HP:0000637)1.80732627
102Malnutrition (HP:0004395)1.80215206
103Distal lower limb muscle weakness (HP:0009053)1.80081297
104Epistaxis (HP:0000421)1.78919251
105Arterial thrombosis (HP:0004420)1.78911139
106Hypochromic anemia (HP:0001931)1.78834813
107Sepsis (HP:0100806)1.77894496
108Vertebral compression fractures (HP:0002953)1.77525826
109Pulmonary infiltrates (HP:0002113)1.77143324
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77040279
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77040279
112Abnormality of polysaccharide metabolism (HP:0011012)1.77040279
113Abnormality of the thoracic spine (HP:0100711)1.76626307
114Dysostosis multiplex (HP:0000943)1.75944499
115Abnormality of the peritoneum (HP:0002585)1.75843998
116Increased serum ferritin (HP:0003281)1.75602556
117Increased connective tissue (HP:0009025)1.74987326
118Skin ulcer (HP:0200042)1.74344131
119Orchitis (HP:0100796)1.73426210
120Aneurysm (HP:0002617)1.72716408
121Encephalitis (HP:0002383)1.72292614
122Lymphopenia (HP:0001888)1.71865644
123Keratoconjunctivitis sicca (HP:0001097)1.71336607
124Shallow orbits (HP:0000586)1.70661619
125Amyloidosis (HP:0011034)1.70107928
126Hypertriglyceridemia (HP:0002155)1.69803420
127Increased neuronal autofluorescent lipopigment (HP:0002074)1.69741868
128Centrally nucleated skeletal muscle fibers (HP:0003687)1.69580031
129Persistence of primary teeth (HP:0006335)1.69575058
130Abnormality of cells of the lymphoid lineage (HP:0012140)1.69105114
131Long eyelashes (HP:0000527)1.68976656
132Hypergammaglobulinemia (HP:0010702)1.66712821
133Thoracic kyphosis (HP:0002942)1.66653651
134Neuronal loss in central nervous system (HP:0002529)1.66579374
135B lymphocytopenia (HP:0010976)1.65706907
136Abnormality of B cell number (HP:0010975)1.65706907
137Thick nail (HP:0001805)1.64977801
138Bicuspid aortic valve (HP:0001647)1.64103990
139Abnormality of T cell physiology (HP:0011840)1.62707046

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.95539455
2ERN13.92601886
3PRPF4B3.87723582
4CDK123.33266472
5MAP3K103.14673235
6TRIB32.91448214
7EPHB12.44772526
8SMG12.44095405
9EEF2K2.27099324
10SIK22.08130147
11TYK21.93453892
12ICK1.76244877
13GRK61.73164565
14TBK11.70777781
15STK101.65414339
16SIK11.64721966
17PKN21.62494640
18RIPK41.59095094
19IKBKE1.54686520
20JAK11.51672122
21JAK31.50994286
22ZAP701.49291842
23BMX1.48391225
24FGFR41.46974302
25TAOK21.46884340
26MAP3K31.46488813
27CSK1.44902416
28PTK61.43325344
29CAMK1G1.40248698
30TGFBR21.38382494
31HCK1.34906615
32TXK1.34829455
33TAOK31.33857122
34BTK1.33114290
35BLK1.32587353
36MAP3K141.31195681
37RIPK11.30895794
38DMPK1.30634191
39CAMK1D1.26271764
40CDC42BPA1.22597137
41TTN1.22278282
42TAOK11.20417848
43FGFR31.15789134
44LRRK21.13586936
45SYK1.12455834
46IKBKB1.12442874
47CHUK1.09340843
48CSF1R1.09271280
49KSR21.07978706
50ALK1.04918475
51PRKD21.03354614
52ITK1.03116529
53IRAK41.02332260
54HIPK21.01669927
55IRAK31.00213783
56PDPK10.98977424
57KIT0.97781114
58IRAK20.96602238
59CDK60.94838558
60PIM10.93205294
61CLK10.91836650
62RPS6KA40.91380024
63MAP3K70.90309096
64LCK0.90288714
65MARK30.89064774
66MTOR0.88628548
67JAK20.86268300
68EPHA30.84199617
69DYRK1B0.83480848
70PDK10.83040289
71FES0.82740708
72DDR20.80555596
73MARK20.80378425
74NME20.79781912
75TESK10.79300634
76SIK30.79264048
77MAP3K130.77945321
78RPS6KA20.76002336
79CDK40.74777873
80BRD40.74640569
81TESK20.73779064
82PDGFRB0.73653732
83MAP2K20.72657427
84PRKCH0.71523717
85IRAK10.62857224
86STK40.62837991
87CAMKK10.61479289
88TYRO30.60978899
89FGR0.60938024
90LYN0.59462958
91PAK40.58376060
92MAP3K110.58307328
93SGK30.56584242
94STK380.54636519
95TNK20.53963797
96PRKD30.53882303
97EGFR0.53768657
98PRKD10.53674374
99STK30.51443370
100MAPKAPK20.51254167
101RET0.51103143
102PDGFRA0.50745473
103RPS6KA60.50407604
104EPHA20.49943227
105MAPK70.49590271
106MAP3K10.49543545
107PTK20.49409619
108ABL10.48358892
109MAP3K20.47785628
110MAPK110.46946416
111MAP3K80.46939910
112WNK10.46843198
113MAP2K30.45913444
114NLK0.45108409
115MAPK150.44838461
116RPS6KL10.44675131
117RPS6KC10.44675131
118MAPK120.44032995
119MAP3K60.42731235
120TRPM70.41735630
121RPS6KA10.41589145
122MATK0.40740531
123NEK20.39931233
124PAK20.38370791

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046622.55380881
2Primary immunodeficiency_Homo sapiens_hsa053402.43919958
3Osteoclast differentiation_Homo sapiens_hsa043802.42291563
4Leishmaniasis_Homo sapiens_hsa051402.32009366
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.94074146
6Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.90843361
7Chronic myeloid leukemia_Homo sapiens_hsa052201.84309822
8Acute myeloid leukemia_Homo sapiens_hsa052211.81701608
9Measles_Homo sapiens_hsa051621.75373625
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.72977651
11T cell receptor signaling pathway_Homo sapiens_hsa046601.68639944
12Toxoplasmosis_Homo sapiens_hsa051451.65780315
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64932384
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61191237
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48650911
16Hematopoietic cell lineage_Homo sapiens_hsa046401.48477416
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43265315
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42371790
19Antigen processing and presentation_Homo sapiens_hsa046121.42044780
20Tuberculosis_Homo sapiens_hsa051521.40557389
21Staphylococcus aureus infection_Homo sapiens_hsa051501.40388667
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.38993122
23Autoimmune thyroid disease_Homo sapiens_hsa053201.37801915
24Intestinal immune network for IgA production_Homo sapiens_hsa046721.37255107
25TNF signaling pathway_Homo sapiens_hsa046681.36792540
26Chemokine signaling pathway_Homo sapiens_hsa040621.36288044
27Pancreatic cancer_Homo sapiens_hsa052121.35668203
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.35396894
29Notch signaling pathway_Homo sapiens_hsa043301.32649452
30Lysine degradation_Homo sapiens_hsa003101.31931757
31Influenza A_Homo sapiens_hsa051641.31492547
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31004263
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.30939169
34Hepatitis B_Homo sapiens_hsa051611.30767805
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27907967
36Malaria_Homo sapiens_hsa051441.27803583
37Dorso-ventral axis formation_Homo sapiens_hsa043201.26738412
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.23898866
39Herpes simplex infection_Homo sapiens_hsa051681.22985349
40Apoptosis_Homo sapiens_hsa042101.22702188
41Shigellosis_Homo sapiens_hsa051311.21631581
42Viral myocarditis_Homo sapiens_hsa054161.21037662
43Neurotrophin signaling pathway_Homo sapiens_hsa047221.20160641
44Pertussis_Homo sapiens_hsa051331.17603374
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.14200171
46Non-small cell lung cancer_Homo sapiens_hsa052231.13399764
47Platelet activation_Homo sapiens_hsa046111.12919186
48Small cell lung cancer_Homo sapiens_hsa052221.12005438
49VEGF signaling pathway_Homo sapiens_hsa043701.11564220
50Insulin resistance_Homo sapiens_hsa049311.08054783
51mTOR signaling pathway_Homo sapiens_hsa041501.07547665
52Glycosaminoglycan degradation_Homo sapiens_hsa005311.01796169
53Prolactin signaling pathway_Homo sapiens_hsa049171.01007952
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00973911
55Proteoglycans in cancer_Homo sapiens_hsa052050.99258964
56Salmonella infection_Homo sapiens_hsa051320.97009598
57Type II diabetes mellitus_Homo sapiens_hsa049300.96365552
58Renal cell carcinoma_Homo sapiens_hsa052110.96200899
59Amoebiasis_Homo sapiens_hsa051460.94230318
60Type I diabetes mellitus_Homo sapiens_hsa049400.93658150
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.92700246
62MicroRNAs in cancer_Homo sapiens_hsa052060.92581676
63Hepatitis C_Homo sapiens_hsa051600.91903683
64GnRH signaling pathway_Homo sapiens_hsa049120.91567168
65Legionellosis_Homo sapiens_hsa051340.90473730
66Lysosome_Homo sapiens_hsa041420.86395636
67Prion diseases_Homo sapiens_hsa050200.86242054
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84404730
69Adherens junction_Homo sapiens_hsa045200.82320563
70HTLV-I infection_Homo sapiens_hsa051660.82185043
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81474772
72Colorectal cancer_Homo sapiens_hsa052100.80898034
73Endocytosis_Homo sapiens_hsa041440.79835017
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78269357
75Focal adhesion_Homo sapiens_hsa045100.77907489
76Graft-versus-host disease_Homo sapiens_hsa053320.76894164
77FoxO signaling pathway_Homo sapiens_hsa040680.76696616
78Glioma_Homo sapiens_hsa052140.74837042
79Thyroid cancer_Homo sapiens_hsa052160.73824756
80MAPK signaling pathway_Homo sapiens_hsa040100.73278224
81Asthma_Homo sapiens_hsa053100.71636204
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.71443065
83Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70680778
84Endometrial cancer_Homo sapiens_hsa052130.70496331
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70338807
86Allograft rejection_Homo sapiens_hsa053300.69929168
87Prostate cancer_Homo sapiens_hsa052150.68325020
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67335747
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67281167
90Viral carcinogenesis_Homo sapiens_hsa052030.66129966
91Phagosome_Homo sapiens_hsa041450.63427421
92HIF-1 signaling pathway_Homo sapiens_hsa040660.62183968
93Estrogen signaling pathway_Homo sapiens_hsa049150.61737717
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.61410542
95Choline metabolism in cancer_Homo sapiens_hsa052310.60641678
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.60241467
97African trypanosomiasis_Homo sapiens_hsa051430.59688699
98Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58483881
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57917076
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57005674
101ErbB signaling pathway_Homo sapiens_hsa040120.55614566
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55096408
103Rap1 signaling pathway_Homo sapiens_hsa040150.54129110
104Pathways in cancer_Homo sapiens_hsa052000.54100300
105Bladder cancer_Homo sapiens_hsa052190.53879503
106Insulin signaling pathway_Homo sapiens_hsa049100.51117769
107Epstein-Barr virus infection_Homo sapiens_hsa051690.50416283
108Inositol phosphate metabolism_Homo sapiens_hsa005620.48138995
109AMPK signaling pathway_Homo sapiens_hsa041520.47858464
110Other glycan degradation_Homo sapiens_hsa005110.47192175

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »