FBRSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)5.90991694
2histone H4-K12 acetylation (GO:0043983)5.62554595
3regulation of hippo signaling (GO:0035330)5.07869916
4intracellular estrogen receptor signaling pathway (GO:0030520)4.73250417
5histone H4-K5 acetylation (GO:0043981)4.70225193
6histone H4-K8 acetylation (GO:0043982)4.70225193
7pre-miRNA processing (GO:0031054)4.63380192
8histone H4-K16 acetylation (GO:0043984)3.98227303
93-UTR-mediated mRNA stabilization (GO:0070935)3.94671531
10regulation of meiosis I (GO:0060631)3.92379511
11heterochromatin organization (GO:0070828)3.90257222
12mannose metabolic process (GO:0006013)3.82575285
13histone H2A monoubiquitination (GO:0035518)3.74815070
14DNA damage response, signal transduction resulting in transcription (GO:0042772)3.64124099
15synaptonemal complex assembly (GO:0007130)3.63284384
16regulation of posttranscriptional gene silencing (GO:0060147)3.61748442
17regulation of gene silencing by miRNA (GO:0060964)3.61748442
18regulation of gene silencing by RNA (GO:0060966)3.61748442
19paraxial mesoderm development (GO:0048339)3.60358540
20negative regulation of histone methylation (GO:0031061)3.58300820
21male sex determination (GO:0030238)3.58243121
22DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.55749129
23regulation of chromatin binding (GO:0035561)3.54839555
24cell-cell junction maintenance (GO:0045217)3.54343026
25poly(A)+ mRNA export from nucleus (GO:0016973)3.51319783
26histone H3-K4 methylation (GO:0051568)3.50740255
27regulation of mammary gland epithelial cell proliferation (GO:0033599)3.43189862
28trophectodermal cell differentiation (GO:0001829)3.42061028
29negative regulation of cell size (GO:0045792)3.40594966
30dosage compensation (GO:0007549)3.36476962
31thymic T cell selection (GO:0045061)3.35747246
32growth hormone secretion (GO:0030252)3.34241511
33activation of Rac GTPase activity (GO:0032863)3.34054950
34positive regulation of SMAD protein import into nucleus (GO:0060391)3.32177418
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.31595972
36sex determination (GO:0007530)3.29340759
37regulation of RNA export from nucleus (GO:0046831)3.28584746
38negative regulation of glial cell proliferation (GO:0060253)3.26563250
39inner cell mass cell proliferation (GO:0001833)3.26160486
40regulation of ARF GTPase activity (GO:0032312)3.25793190
41modulation by virus of host process (GO:0019054)3.24528312
42maternal placenta development (GO:0001893)3.21940499
43adherens junction assembly (GO:0034333)3.21322866
44intestinal epithelial cell development (GO:0060576)3.19625621
45negative regulation of myotube differentiation (GO:0010832)3.19535361
46histone H3-K9 demethylation (GO:0033169)3.19352160
47synaptonemal complex organization (GO:0070193)3.18841514
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.18470756
49regulation of sister chromatid cohesion (GO:0007063)3.17544457
50nodal signaling pathway (GO:0038092)3.15042030
51positive thymic T cell selection (GO:0045059)3.13410067
52regulation of early endosome to late endosome transport (GO:2000641)3.12452657
53regulation of nuclear cell cycle DNA replication (GO:0033262)3.11867052
54cytoplasmic mRNA processing body assembly (GO:0033962)3.11678930
55semaphorin-plexin signaling pathway (GO:0071526)3.11606197
56peptidyl-tyrosine autophosphorylation (GO:0038083)3.03713952
57apoptotic process involved in development (GO:1902742)3.00411411
58regulation of telomere maintenance via telomerase (GO:0032210)2.99293162
59anatomical structure regression (GO:0060033)2.99273201
60negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.97978731
61positive regulation of CREB transcription factor activity (GO:0032793)2.97842137
62regulation of SMAD protein import into nucleus (GO:0060390)2.97059607
63regulation of ARF protein signal transduction (GO:0032012)2.96267060
64positive regulation of protein deacetylation (GO:0090312)2.96018778
65histone H3 acetylation (GO:0043966)2.95737091
66regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.95671373
67positive regulation of gene expression, epigenetic (GO:0045815)2.95652817
68negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.94139790
69signal complex assembly (GO:0007172)2.93614537
70activation of MAPKKK activity (GO:0000185)2.92178987
71atrioventricular valve morphogenesis (GO:0003181)2.91235582
72cell-substrate adherens junction assembly (GO:0007045)2.91165177
73focal adhesion assembly (GO:0048041)2.91165177
74modulation by symbiont of host cellular process (GO:0044068)2.91132439
75negative regulation of meiosis (GO:0045835)2.90416791
76negative regulation of Ras GTPase activity (GO:0034261)2.90139652
77response to UV-C (GO:0010225)2.88733725
78negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.88573583
79oogenesis (GO:0048477)2.87808283
80histone H4 acetylation (GO:0043967)2.86513121
81regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.85850458
82lymph vessel development (GO:0001945)2.84763586
83positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84381891
84response to laminar fluid shear stress (GO:0034616)2.82984652
85response to muramyl dipeptide (GO:0032495)2.82761875
86protein localization to chromosome (GO:0034502)2.80700951
87histone lysine demethylation (GO:0070076)2.80678310
88regulation of double-strand break repair via homologous recombination (GO:0010569)2.80523544
89histone H4 deacetylation (GO:0070933)2.79150385
90RNA stabilization (GO:0043489)2.78983927
91mRNA stabilization (GO:0048255)2.78983927
92intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.78935589
93regulation of glucose import in response to insulin stimulus (GO:2001273)2.78764527
94epithelial cell fate commitment (GO:0072148)2.78539585
95histone H2A ubiquitination (GO:0033522)2.78457323
96nuclear pore organization (GO:0006999)2.74975647
97positive regulation of Cdc42 GTPase activity (GO:0043089)2.74876449
98ovulation cycle (GO:0042698)2.74473705
99nuclear pore complex assembly (GO:0051292)2.73965914
100piRNA metabolic process (GO:0034587)2.73427727
101NLS-bearing protein import into nucleus (GO:0006607)2.73283978
102gene silencing by RNA (GO:0031047)2.73223959
103DNA alkylation (GO:0006305)2.73155777
104DNA methylation (GO:0006306)2.73155777
105glial cell proliferation (GO:0014009)2.72105542
106histone H3-K36 demethylation (GO:0070544)2.72064752
107mitotic chromosome condensation (GO:0007076)2.71844996
108female gamete generation (GO:0007292)2.71514717
109protein localization to kinetochore (GO:0034501)2.71204567
110regulation of fatty acid beta-oxidation (GO:0031998)2.70979186
111negative regulation of potassium ion transmembrane transport (GO:1901380)2.70785031
112regulation of NFAT protein import into nucleus (GO:0051532)2.69571877
113positive regulation of histone deacetylation (GO:0031065)2.69529293
114histone methylation (GO:0016571)2.67885692
115histone demethylation (GO:0016577)2.67823932
116mitotic metaphase plate congression (GO:0007080)2.66943626
117embryonic placenta development (GO:0001892)2.66850270
118osteoblast development (GO:0002076)2.66756651
119stress granule assembly (GO:0034063)2.65930997
120cell migration in hindbrain (GO:0021535)2.65419633
121gene silencing (GO:0016458)2.65212324
122regulation of histone H3-K27 methylation (GO:0061085)2.65198008
123regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.64843381
124histone H3 deacetylation (GO:0070932)2.64647993
125regulation of histone deacetylation (GO:0031063)2.64538970
126epithelial cell differentiation involved in prostate gland development (GO:0060742)2.64153495
127positive regulation of male gonad development (GO:2000020)2.64065717
128regulation of nucleobase-containing compound transport (GO:0032239)2.63810268
129cell junction maintenance (GO:0034331)2.63736802
130female genitalia development (GO:0030540)2.63363534
131histone acetylation (GO:0016573)2.63170499
132histone H3-K9 methylation (GO:0051567)2.62371800
133histone lysine methylation (GO:0034968)2.62227858
134activation of JUN kinase activity (GO:0007257)2.61798816
135T cell selection (GO:0045058)2.61425893
136internal peptidyl-lysine acetylation (GO:0018393)2.61279403
137G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.61170522
138negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.60053387
139negative regulation of cell killing (GO:0031342)2.60053387
140mitotic G1 DNA damage checkpoint (GO:0031571)2.60048086
141modulation by virus of host morphology or physiology (GO:0019048)2.59471334
142maintenance of protein location in nucleus (GO:0051457)2.58448319
143negative regulation of viral release from host cell (GO:1902187)2.58088933
144negative regulation of fatty acid transport (GO:2000192)2.57160841
145peptidyl-lysine acetylation (GO:0018394)2.56647612
146negative regulation of mRNA processing (GO:0050686)2.56198353
147positive regulation of chromosome segregation (GO:0051984)2.55478938
148respiratory system process (GO:0003016)2.55000022
149apoptotic process involved in morphogenesis (GO:0060561)2.54933006
150regulation of double-strand break repair (GO:2000779)2.54367724
151notochord development (GO:0030903)2.54039271
152establishment of apical/basal cell polarity (GO:0035089)2.53054339
153labyrinthine layer blood vessel development (GO:0060716)2.52807413
154regulation of glial cell proliferation (GO:0060251)2.52403018
155positive regulation of Rap GTPase activity (GO:0032854)2.52331622
156endothelial cell chemotaxis (GO:0035767)2.52173333
157chromatin assembly (GO:0031497)2.52085050
158entrainment of circadian clock by photoperiod (GO:0043153)2.51696377
159response to peptidoglycan (GO:0032494)2.50237428
160negative regulation of striated muscle cell differentiation (GO:0051154)2.49178736
161positive regulation of synapse maturation (GO:0090129)2.48572657
162cytoskeletal anchoring at plasma membrane (GO:0007016)2.46413593
163regulation of extracellular matrix disassembly (GO:0010715)2.45294945
164histone H3-K4 trimethylation (GO:0080182)2.44811550
165protein localization to endosome (GO:0036010)2.42541291
166embryonic process involved in female pregnancy (GO:0060136)2.42428695
167vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41478049
168mammary gland epithelial cell differentiation (GO:0060644)2.39516105
169dopamine receptor signaling pathway (GO:0007212)2.38526961
170negative regulation of granulocyte differentiation (GO:0030853)2.38009064
171neural tube development (GO:0021915)2.37906516
172glucocorticoid receptor signaling pathway (GO:0042921)2.36669801
173positive regulation of myotube differentiation (GO:0010831)2.36069393
174embryonic eye morphogenesis (GO:0048048)2.35866018
175positive regulation by symbiont of host defense response (GO:0052509)2.35692377
176modulation by symbiont of host defense response (GO:0052031)2.35692377
177modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.35692377
178modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.35692377
179positive regulation by organism of defense response of other organism involved in symbiotic interact2.35692377
180modulation by symbiont of host immune response (GO:0052553)2.35692377
181diaphragm development (GO:0060539)2.35667446
182cellular response to virus (GO:0098586)2.34917765
183positive regulation of protein dephosphorylation (GO:0035307)2.33897038
184negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.33495057
185response to parathyroid hormone (GO:0071107)2.32799026

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.57334070
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.57334070
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.57334070
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.19262499
5E2F7_22180533_ChIP-Seq_HELA_Human3.05416411
6SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.01588400
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.91641253
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.83200389
9MYC_22102868_ChIP-Seq_BL_Human2.68952923
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.58668691
11ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.56475740
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.51195557
13SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.46148415
14* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.29726431
15* KDM2B_26808549_Chip-Seq_DND41_Human2.26199166
16ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.22487551
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21838337
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20029815
19ZNF263_19887448_ChIP-Seq_K562_Human2.18908686
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.18007042
21* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14207343
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.13607995
23TCF7_22412390_ChIP-Seq_EML_Mouse2.12788936
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11951011
25NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.11810347
26ZFP281_27345836_Chip-Seq_ESCs_Mouse2.11210563
27* KDM2B_26808549_Chip-Seq_K562_Human2.03305215
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03176693
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.98509244
30* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.98288420
31SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.97599431
32* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94027473
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.86592875
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.86130479
35VDR_24763502_ChIP-Seq_THP-1_Human1.84458617
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77421409
37POU5F1_16518401_ChIP-PET_MESCs_Mouse1.77059889
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76587315
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.75365458
40NANOG_21062744_ChIP-ChIP_HESCs_Human1.71459000
41TET1_21451524_ChIP-Seq_MESCs_Mouse1.70717787
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.68296988
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.67937242
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.66655989
45VDR_21846776_ChIP-Seq_THP-1_Human1.64303939
46DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.63273151
47* KDM2B_26808549_Chip-Seq_JURKAT_Human1.60194233
48CREB1_26743006_Chip-Seq_LNCaP_Human1.58511902
49NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.55555952
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53572378
51* MAF_26560356_Chip-Seq_TH1_Human1.53495627
52CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51908782
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51876743
54* MAF_26560356_Chip-Seq_TH2_Human1.51762756
55RACK7_27058665_Chip-Seq_MCF-7_Human1.49883129
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.49673111
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.47768622
58LXR_22292898_ChIP-Seq_THP-1_Human1.45403563
59SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45238401
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45071508
61CTCF_27219007_Chip-Seq_Bcells_Human1.44064392
62KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39655682
63PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.39243792
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38236721
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38103531
66CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37475450
67TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.35255414
68P300_27058665_Chip-Seq_ZR-75-30cells_Human1.33308268
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31832883
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.31716625
71RUNX1_22412390_ChIP-Seq_EML_Mouse1.31586313
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.30452595
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.29505244
74* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.27094938
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27056936
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26593944
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25111950
78ATF3_27146783_Chip-Seq_COLON_Human1.24319400
79* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23979741
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23369959
81BCOR_27268052_Chip-Seq_Bcells_Human1.23186331
82NCOR1_26117541_ChIP-Seq_K562_Human1.22866409
83SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22483871
84PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22072669
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21644161
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.21052685
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20599505
88KDM5A_27292631_Chip-Seq_BREAST_Human1.18857013
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18481013
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17898268
91FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17566315
92EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17565326
93HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16774002
94BCL6_27268052_Chip-Seq_Bcells_Human1.15971817
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15689779
96POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14953859
97* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.14651899
98NANOG_18692474_ChIP-Seq_MESCs_Mouse1.13763222
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.13396901
100* RUNX1_27514584_Chip-Seq_MCF-7_Human1.12990353
101SOX2_18692474_ChIP-Seq_MESCs_Mouse1.12525777
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10929125
103SCL_19346495_ChIP-Seq_HPC-7_Human1.09651232
104KAP1_27257070_Chip-Seq_ESCs_Mouse1.09492046
105TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09166890
106SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.09019172
107P68_20966046_ChIP-Seq_HELA_Human1.08559957
108TP63_17297297_ChIP-ChIP_HaCaT_Human1.08123269
109BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07901272
110GATA1_19941827_ChIP-Seq_MEL_Mouse1.07428988
111GATA1_22383799_ChIP-Seq_G1ME_Mouse1.07010985
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06801753
113STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.06629951
114CIITA_25753668_ChIP-Seq_RAJI_Human1.05658163
115* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05626715
116GATA1_26923725_Chip-Seq_HPCs_Mouse1.04542784
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.04342813
118SMC4_20622854_ChIP-Seq_HELA_Human1.04203078
119SALL1_21062744_ChIP-ChIP_HESCs_Human1.03848257
120RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03738654
121CTCF_21964334_ChIP-Seq_BJAB-B_Human1.03203711
122RARB_27405468_Chip-Seq_BRAIN_Mouse1.02271777
123PHF8_20622854_ChIP-Seq_HELA_Human1.02158120
124SA1_27219007_Chip-Seq_Bcells_Human1.01943652
125TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01707753
126POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.01058719
127POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00833952
128RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00824006
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00150267
130* TP63_22573176_ChIP-Seq_HFKS_Human0.99937781
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99895686
132* UTX_26944678_Chip-Seq_JUKART_Human0.98973459
133* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98967450
134EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.98518388
135SA1_27219007_Chip-Seq_ERYTHROID_Human0.98268770
136CTCF_26484167_Chip-Seq_Bcells_Mouse0.98146248
137PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98019802
138OCT4_19829295_ChIP-Seq_ESCs_Human0.97707036
139CHD1_26751641_Chip-Seq_LNCaP_Human0.96363128
140CTCF_21964334_Chip-Seq_Bcells_Human0.96299602
141* DROSHA_22980978_ChIP-Seq_HELA_Human0.96202550
142SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96201490
143* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94771295
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.94694972
145RARB_24833708_ChIP-Seq_LIVER_Mouse0.93902921
146RARA_24833708_ChIP-Seq_LIVER_Mouse0.93046667
147ETS1_21867929_ChIP-Seq_TH2_Mouse0.93031276
148CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91489007
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90900777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.83716043
2MP0008995_early_reproductive_senescence3.52771749
3MP0008057_abnormal_DNA_replication2.96009007
4MP0008877_abnormal_DNA_methylation2.88379385
5MP0005451_abnormal_body_composition2.78902406
6MP0005409_darkened_coat_color2.52340396
7MP0005076_abnormal_cell_differentiation2.49199355
8MP0009278_abnormal_bone_marrow2.35957486
9MP0003111_abnormal_nucleus_morphology2.35403364
10MP0003172_abnormal_lysosome_physiology2.31997491
11MP0003705_abnormal_hypodermis_morpholog2.28484069
12MP0003890_abnormal_embryonic-extraembry2.25122344
13MP0003303_peritoneal_inflammation2.22724566
14MP0006292_abnormal_olfactory_placode2.21867122
15MP0003436_decreased_susceptibility_to2.17136584
16MP0003693_abnormal_embryo_hatching2.16427152
17MP0004957_abnormal_blastocyst_morpholog2.11398386
18MP0003283_abnormal_digestive_organ2.07985787
19MP0003119_abnormal_digestive_system2.06942392
20MP0003077_abnormal_cell_cycle2.03716846
21MP0005058_abnormal_lysosome_morphology2.03272594
22MP0008961_abnormal_basal_metabolism2.01532333
23MP0002084_abnormal_developmental_patter1.92871329
24MP0000566_synostosis1.82387797
25MP0010352_gastrointestinal_tract_polyps1.81620329
26MP0004185_abnormal_adipocyte_glucose1.80551015
27MP0002085_abnormal_embryonic_tissue1.77518980
28MP0008260_abnormal_autophagy1.76289749
29MP0001672_abnormal_embryogenesis/_devel1.74642037
30MP0005380_embryogenesis_phenotype1.74642037
31MP0001873_stomach_inflammation1.74555447
32MP0000350_abnormal_cell_proliferation1.71004075
33MP0001348_abnormal_lacrimal_gland1.68437689
34MP0004381_abnormal_hair_follicle1.67665069
35MP0001730_embryonic_growth_arrest1.63650533
36MP0002088_abnormal_embryonic_growth/wei1.60688863
37MP0003984_embryonic_growth_retardation1.59568322
38MP0003787_abnormal_imprinting1.58050704
39MP0010030_abnormal_orbit_morphology1.57996482
40MP0002796_impaired_skin_barrier1.56276330
41MP0002086_abnormal_extraembryonic_tissu1.55650993
42MP0002396_abnormal_hematopoietic_system1.54192540
43MP0004264_abnormal_extraembryonic_tissu1.52390627
44MP0010094_abnormal_chromosome_stability1.51479084
45MP0001697_abnormal_embryo_size1.50075557
46MP0005377_hearing/vestibular/ear_phenot1.47468122
47MP0003878_abnormal_ear_physiology1.47468122
48MP0004947_skin_inflammation1.46016401
49MP0002254_reproductive_system_inflammat1.41403544
50MP0003763_abnormal_thymus_physiology1.40317236
51MP0001849_ear_inflammation1.37414483
52MP0002210_abnormal_sex_determination1.36928678
53MP0003786_premature_aging1.34115792
54MP0001346_abnormal_lacrimal_gland1.34045268
55MP0003121_genomic_imprinting1.33948060
56MP0005670_abnormal_white_adipose1.33032136
57MP0004197_abnormal_fetal_growth/weight/1.29044433
58MP0009379_abnormal_foot_pigmentation1.27326804
59MP0008058_abnormal_DNA_repair1.26819201
60MP0009333_abnormal_splenocyte_physiolog1.24800336
61MP0002089_abnormal_postnatal_growth/wei1.24232853
62MP0001145_abnormal_male_reproductive1.24164869
63MP0009840_abnormal_foam_cell1.23172953
64MP0002127_abnormal_cardiovascular_syste1.22153275
65MP0008007_abnormal_cellular_replicative1.20152677
66MP0002877_abnormal_melanocyte_morpholog1.19901402
67MP0003935_abnormal_craniofacial_develop1.18396454
68MP0002249_abnormal_larynx_morphology1.18010214
69MP0000003_abnormal_adipose_tissue1.17518613
70MP0005310_abnormal_salivary_gland1.17002236
71MP0001188_hyperpigmentation1.15902699
72MP0000703_abnormal_thymus_morphology1.15516725
73MP0004130_abnormal_muscle_cell1.14008449
74MP0002080_prenatal_lethality1.13706782
75MP0003879_abnormal_hair_cell1.13024018
76MP0003045_fibrosis1.12382415
77MP0005501_abnormal_skin_physiology1.11873420
78MP0003300_gastrointestinal_ulcer1.11001890
79MP0002009_preneoplasia1.10644139
80MP0000681_abnormal_thyroid_gland1.10123419
81MP0001929_abnormal_gametogenesis1.10000471
82MP0004233_abnormal_muscle_weight1.09800545
83MP0003123_paternal_imprinting1.09168833
84MP0001293_anophthalmia1.09002548
85MP0000462_abnormal_digestive_system1.08481179
86MP0003861_abnormal_nervous_system1.07578712
87MP0000428_abnormal_craniofacial_morphol1.07326826
88MP0004859_abnormal_synaptic_plasticity1.06795426
89MP0004133_heterotaxia1.06684288
90MP0003567_abnormal_fetal_cardiomyocyte1.06643946
91MP0000653_abnormal_sex_gland1.06552669
92MP0004808_abnormal_hematopoietic_stem1.06053818
93MP0009053_abnormal_anal_canal1.05669229
94MP0005666_abnormal_adipose_tissue1.05647827
95MP0001727_abnormal_embryo_implantation1.04522754
96MP0010234_abnormal_vibrissa_follicle1.03398855
97MP0003936_abnormal_reproductive_system1.01059886
98MP0000858_altered_metastatic_potential1.00530170
99MP0000733_abnormal_muscle_development1.00058389
100MP0009672_abnormal_birth_weight0.99880408
101MP0010307_abnormal_tumor_latency0.99459163
102MP0000537_abnormal_urethra_morphology0.98809188
103MP0009703_decreased_birth_body0.98499377
104MP0002925_abnormal_cardiovascular_devel0.98363991
105MP0010630_abnormal_cardiac_muscle0.98206550
106MP0002092_abnormal_eye_morphology0.96895612
107MP0006072_abnormal_retinal_apoptosis0.96831853
108MP0005248_abnormal_Harderian_gland0.94884579
109MP0000759_abnormal_skeletal_muscle0.94152196
110MP0000432_abnormal_head_morphology0.93457722
111MP0002234_abnormal_pharynx_morphology0.93119299
112MP0003755_abnormal_palate_morphology0.92459366
113MP0002932_abnormal_joint_morphology0.91963550
114MP0000490_abnormal_crypts_of0.91559610
115MP0003942_abnormal_urinary_system0.90933981
116MP0004885_abnormal_endolymph0.89221249
117MP0004858_abnormal_nervous_system0.89035282
118MP0004084_abnormal_cardiac_muscle0.87580623
119MP0002398_abnormal_bone_marrow0.87190678
120MP0002116_abnormal_craniofacial_bone0.86866071
121MP0001545_abnormal_hematopoietic_system0.86337272
122MP0005397_hematopoietic_system_phenotyp0.86337272
123MP0001784_abnormal_fluid_regulation0.85617321
124MP0003091_abnormal_cell_migration0.85213317
125MP0005375_adipose_tissue_phenotype0.84346147
126MP0005623_abnormal_meninges_morphology0.84046637
127MP0004087_abnormal_muscle_fiber0.84025213
128MP0003115_abnormal_respiratory_system0.83896849
129MP0000266_abnormal_heart_morphology0.83604991
130MP0009931_abnormal_skin_appearance0.83548762
131MP0000470_abnormal_stomach_morphology0.83379489
132MP0000313_abnormal_cell_death0.82903419
133MP0002098_abnormal_vibrissa_morphology0.81622104
134MP0005257_abnormal_intraocular_pressure0.81607503
135MP0001502_abnormal_circadian_rhythm0.80976632
136MP0000751_myopathy0.80920043
137MP0003866_abnormal_defecation0.80435736
138MP0003828_pulmonary_edema0.79622006
139MP0002998_abnormal_bone_remodeling0.79127577
140MP0002697_abnormal_eye_size0.78959710
141MP0005621_abnormal_cell_physiology0.78345083
142MP0000678_abnormal_parathyroid_gland0.78193608
143MP0000750_abnormal_muscle_regeneration0.78175379
144MP0002970_abnormal_white_adipose0.77251210
145MP0006138_congestive_heart_failure0.77174985
146MP0005025_abnormal_response_to0.76949509
147MP0004510_myositis0.75490105
148MP0003699_abnormal_female_reproductive0.74234177
149MP0003329_amyloid_beta_deposits0.74210123
150MP0005647_abnormal_sex_gland0.74195399
151MP0003453_abnormal_keratinocyte_physiol0.73638370
152MP0001119_abnormal_female_reproductive0.73447137
153MP0010155_abnormal_intestine_physiology0.72995347
154MP0003566_abnormal_cell_adhesion0.72075547
155MP0003948_abnormal_gas_homeostasis0.69455988
156MP0000477_abnormal_intestine_morphology0.67828319
157MP0000716_abnormal_immune_system0.67759387
158MP0001819_abnormal_immune_cell0.67102568
159MP0002420_abnormal_adaptive_immunity0.67030872
160MP0005423_abnormal_somatic_nervous0.65475194
161MP0001790_abnormal_immune_system0.64615400
162MP0005387_immune_system_phenotype0.64615400
163MP0002722_abnormal_immune_system0.64446161
164MP0001800_abnormal_humoral_immune0.64099560
165MP0002822_catalepsy0.63813695
166MP0002429_abnormal_blood_cell0.63179738
167MP0002114_abnormal_axial_skeleton0.62479703
168MP0003279_aneurysm0.62438214
169MP0003191_abnormal_cellular_cholesterol0.61423330
170MP0002419_abnormal_innate_immunity0.60698703

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)4.11076047
2Sex reversal (HP:0012245)3.63398940
3Abnormal sex determination (HP:0012244)3.63398940
4Rib fusion (HP:0000902)3.52471168
5Facial hemangioma (HP:0000329)3.43853827
6Broad face (HP:0000283)3.40526983
7Ependymoma (HP:0002888)3.25372747
8Abnormality of the labia minora (HP:0012880)3.08830003
9Shawl scrotum (HP:0000049)3.06128427
10Abnormality of the fingertips (HP:0001211)2.99818110
11Abnormality of the lower motor neuron (HP:0002366)2.98650484
12Distal lower limb amyotrophy (HP:0008944)2.89837704
13Hyperacusis (HP:0010780)2.87171913
14Hyperthyroidism (HP:0000836)2.81429834
15Rectal prolapse (HP:0002035)2.79802862
16Disproportionate tall stature (HP:0001519)2.73423237
17Truncus arteriosus (HP:0001660)2.73270510
18Neoplasm of the oral cavity (HP:0100649)2.72158478
19Patellar aplasia (HP:0006443)2.66435007
20Oligodactyly (HP:0012165)2.65652979
21Abnormality of the astrocytes (HP:0100707)2.64272075
22Astrocytoma (HP:0009592)2.64272075
23Stridor (HP:0010307)2.62296707
24Thin bony cortex (HP:0002753)2.60926480
25Ulnar bowing (HP:0003031)2.59341179
26Intestinal fistula (HP:0100819)2.57663133
27Long palpebral fissure (HP:0000637)2.53274019
28Eczematoid dermatitis (HP:0000976)2.52471233
29Urethral obstruction (HP:0000796)2.51951089
30Myopathic facies (HP:0002058)2.50067653
31Germ cell neoplasia (HP:0100728)2.50032647
32Anal stenosis (HP:0002025)2.49130847
33Abnormality of the distal phalanx of the thumb (HP:0009617)2.46306761
34Easy fatigability (HP:0003388)2.43989982
35Broad distal phalanx of finger (HP:0009836)2.42202212
36Seborrheic dermatitis (HP:0001051)2.41669093
37Aplasia/Hypoplasia of the patella (HP:0006498)2.39611924
38Dysmetric saccades (HP:0000641)2.39608019
39Hemorrhage of the eye (HP:0011885)2.36820466
40Cerebral aneurysm (HP:0004944)2.35952970
41Hand muscle atrophy (HP:0009130)2.35279782
42Bowel incontinence (HP:0002607)2.34896114
43Abnormality of the thoracic spine (HP:0100711)2.34099471
44Abnormality of the phalanges of the hallux (HP:0010057)2.33451724
45Renal duplication (HP:0000075)2.29466583
46Deep palmar crease (HP:0006191)2.29352879
47Neoplasm of striated muscle (HP:0009728)2.23957642
48Centrally nucleated skeletal muscle fibers (HP:0003687)2.21878589
49Elfin facies (HP:0004428)2.20741076
50Cellulitis (HP:0100658)2.20363063
51Short humerus (HP:0005792)2.18346922
52Renovascular hypertension (HP:0100817)2.17186609
53Abnormality of the aortic arch (HP:0012303)2.16679585
54Abnormal large intestine physiology (HP:0012700)2.14699390
55Increased IgE level (HP:0003212)2.13335344
56Pointed chin (HP:0000307)2.12177105
57Turricephaly (HP:0000262)2.10731846
58Aplasia/hypoplasia of the humerus (HP:0006507)2.10059530
59Missing ribs (HP:0000921)2.09793875
60Polycythemia (HP:0001901)2.08881639
61Achilles tendon contracture (HP:0001771)2.08635531
62Abnormality of the diencephalon (HP:0010662)2.07045526
63Increased connective tissue (HP:0009025)2.04423479
64Bulbar palsy (HP:0001283)2.03925503
65Septate vagina (HP:0001153)2.03445824
66Hypercortisolism (HP:0001578)2.03318271
67Slow saccadic eye movements (HP:0000514)2.03184882
68Lower limb amyotrophy (HP:0007210)2.03106608
69Spina bifida occulta (HP:0003298)2.01472739
70Thoracic kyphosis (HP:0002942)2.00737409
71Rectal fistula (HP:0100590)2.00447932
72Rectovaginal fistula (HP:0000143)2.00447932
73Heterotopia (HP:0002282)2.00228401
74Supernumerary ribs (HP:0005815)1.98850841
75Broad thumb (HP:0011304)1.98517407
76Patellar dislocation (HP:0002999)1.98469589
77Macroorchidism (HP:0000053)1.96595856
78Ankle clonus (HP:0011448)1.96302231
79Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.96099730
80Chronic obstructive pulmonary disease (HP:0006510)1.96026131
81Obstructive lung disease (HP:0006536)1.96026131
82Dislocated radial head (HP:0003083)1.95537398
83Long eyelashes (HP:0000527)1.95278410
84Spinal muscular atrophy (HP:0007269)1.94882597
85Lower limb asymmetry (HP:0100559)1.94047309
86Gonadal dysgenesis (HP:0000133)1.93720678
87Mitral regurgitation (HP:0001653)1.93339928
88Lymphangioma (HP:0100764)1.92816011
89Neoplasm of the heart (HP:0100544)1.92780224
90Distal lower limb muscle weakness (HP:0009053)1.92360615
91Flat acetabular roof (HP:0003180)1.92234552
92Abnormality of the radial head (HP:0003995)1.91951623
93Atelectasis (HP:0100750)1.91608651
94Hypoplastic labia majora (HP:0000059)1.90299617
95Oligodactyly (hands) (HP:0001180)1.90144920
96Insomnia (HP:0100785)1.89934986
97Abnormality of the columella (HP:0009929)1.89916270
98Segmental peripheral demyelination/remyelination (HP:0003481)1.89649165
99Vertebral fusion (HP:0002948)1.89400738
100Colitis (HP:0002583)1.89283767
101Glioma (HP:0009733)1.88526329
102Prominent nose (HP:0000448)1.88416256
103Gastrointestinal inflammation (HP:0004386)1.88008640
104Thin ribs (HP:0000883)1.87446273
105Bronchomalacia (HP:0002780)1.87412071
106Hypertensive crisis (HP:0100735)1.86244808
107Upper limb amyotrophy (HP:0009129)1.86180544
108Distal upper limb amyotrophy (HP:0007149)1.86180544
109Hyperparathyroidism (HP:0000843)1.85679389
110Overriding aorta (HP:0002623)1.85621015
111Genu recurvatum (HP:0002816)1.84634252
112Abnormality of the Achilles tendon (HP:0005109)1.84544041
113Abnormality of chromosome segregation (HP:0002916)1.84349239
114Growth hormone excess (HP:0000845)1.84313456
115Pseudobulbar signs (HP:0002200)1.83468226
116Asymmetric growth (HP:0100555)1.82741882
117Onion bulb formation (HP:0003383)1.81759461
118Oligodontia (HP:0000677)1.80660663
119Stereotypic behavior (HP:0000733)1.79844870
120Annular pancreas (HP:0001734)1.79502314
121Sandal gap (HP:0001852)1.76676852
122Hemivertebrae (HP:0002937)1.76640281
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.76628952
124Reticulocytosis (HP:0001923)1.76408743
125Abnormality of the intervertebral disk (HP:0005108)1.75564442
126Medulloblastoma (HP:0002885)1.74974312
127Supernumerary bones of the axial skeleton (HP:0009144)1.74108091
128Abnormality of male internal genitalia (HP:0000022)1.73413040
129Polygenic inheritance (HP:0010982)1.72845140
130Spinal canal stenosis (HP:0003416)1.72303242
131Short phalanx of the thumb (HP:0009660)1.72083896
132Testicular atrophy (HP:0000029)1.72050953
133Skin pits (HP:0100276)1.71933330
134Supranuclear gaze palsy (HP:0000605)1.71816221
135J-shaped sella turcica (HP:0002680)1.71535516
136Abnormality of the labia majora (HP:0012881)1.71157507
137Increased nuchal translucency (HP:0010880)1.71055285
138Colon cancer (HP:0003003)1.70512850
139Ureteral stenosis (HP:0000071)1.70273610
140Shallow orbits (HP:0000586)1.69893068
141Muscle fibrillation (HP:0010546)1.69766396
142Vaginal fistula (HP:0004320)1.69309895
143Genetic anticipation (HP:0003743)1.68918983
144Concave nail (HP:0001598)1.68895507
145Abnormal number of incisors (HP:0011064)1.68149653
146Neuronal loss in central nervous system (HP:0002529)1.67872647
147Impulsivity (HP:0100710)1.67320108
148Overlapping toe (HP:0001845)1.67056278
149Supernumerary spleens (HP:0009799)1.66907052
150Malignant gastrointestinal tract tumors (HP:0006749)1.65957676
151Gastrointestinal carcinoma (HP:0002672)1.65957676
152Axonal loss (HP:0003447)1.65846014
153Increased variability in muscle fiber diameter (HP:0003557)1.65471350
154Recurrent bacterial skin infections (HP:0005406)1.65266184
155Hypochromic microcytic anemia (HP:0004840)1.63749999
156Difficulty climbing stairs (HP:0003551)1.63736669
157Failure to thrive in infancy (HP:0001531)1.63423631
158Self-mutilation (HP:0000742)1.62577380
159Breast hypoplasia (HP:0003187)1.61603925
160Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61187293
161Abnormality of the distal phalanges of the toes (HP:0010182)1.60934138
162Testicular neoplasm (HP:0010788)1.60907474
163Congenital malformation of the right heart (HP:0011723)1.60826081
164Double outlet right ventricle (HP:0001719)1.60826081
165Aneurysm (HP:0002617)1.60078897
166Metaphyseal cupping (HP:0003021)1.59979728
167Premature skin wrinkling (HP:0100678)1.59652032
168Abnormality of the labia (HP:0000058)1.59572921
169Exercise-induced myalgia (HP:0003738)1.59495915
170Tongue fasciculations (HP:0001308)1.59323813
171Renal cell carcinoma (HP:0005584)1.59151639
172Enlarged penis (HP:0000040)1.59120823
173Obstructive sleep apnea (HP:0002870)1.59073935
174Emphysema (HP:0002097)1.58808862
175Supernumerary nipples (HP:0002558)1.58725096
176Birth length less than 3rd percentile (HP:0003561)1.57166000
177Abnormality of the musculature of the hand (HP:0001421)1.57138693
178Aplasia involving forearm bones (HP:0009822)1.57034763
179Absent forearm bone (HP:0003953)1.57034763
180Absent radius (HP:0003974)1.56624420
181Precocious puberty (HP:0000826)1.56580191
182Premature ovarian failure (HP:0008209)1.56411891
183Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.55521237

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.64175660
2PRPF4B3.86479477
3ICK3.08989890
4TYRO33.04382997
5SMG12.94430726
6LATS22.81088642
7LATS12.73799321
8MAP3K102.62492797
9PRKD32.52874897
10TRIB32.46729298
11IRAK32.44721452
12BRD42.27071255
13NEK22.02111539
14MAPK151.99660765
15PRKD21.92441008
16MAP4K11.87258948
17TNK21.79173491
18MAP3K61.78987284
19CDK71.73730246
20MAP2K31.65886628
21MTOR1.63376272
22MAP3K91.48740364
23MAP3K111.45857050
24TAOK21.45799178
25RIPK41.42684921
26FGFR41.41896404
27EEF2K1.40940309
28TTK1.40591178
29CDK91.37766922
30DMPK1.35527454
31STK38L1.34643868
32SIK21.33357492
33TAOK11.27803907
34NME21.24073641
35ERN11.24019718
36STK381.21131917
37RIPK11.20673029
38IRAK41.19663079
39TTN1.19598633
40PKN21.19425385
41MAP2K21.17668198
42CAMK1D1.16589072
43IRAK21.16523956
44MAP3K131.15313406
45EPHA21.15196973
46CAMKK11.14400337
47ALK1.12855559
48RPS6KA41.12388754
49SIK31.11808804
50DYRK31.10792128
51HIPK21.09599187
52LMTK21.06681556
53BMX1.05110978
54PDGFRA1.03180020
55CHEK21.03018763
56CDK41.02868346
57STK31.02628386
58MAP3K11.01974295
59PAK40.96369605
60MAP3K20.95856960
61PAK60.95438214
62RPS6KA20.94061810
63MAP3K70.93423289
64PTK60.92371814
65RPS6KC10.92212261
66RPS6KL10.92212261
67CDC42BPA0.91515812
68MAP3K30.90401744
69DYRK20.88074549
70CDC70.87777043
71PHKG10.86409851
72PHKG20.86409851
73INSRR0.86125216
74PDPK10.85652629
75MAPK120.85232360
76PRKAA10.83835663
77MARK20.83033223
78EPHB10.82976892
79CAMK1G0.81332021
80CDK20.80097659
81CHEK10.78947119
82STK110.76716009
83KSR20.75876300
84PLK10.74406825
85RPS6KA60.73518783
86CDK60.72248038
87CHUK0.72204125
88PTK20.72057249
89TGFBR20.71470373
90RPS6KA10.71465258
91AKT30.70296971
92GRK60.68709903
93NTRK20.65023215
94MAPK110.60535741
95BTK0.60179197
96DDR20.60019848
97LRRK20.59454300
98PRKCI0.59445852
99DYRK1B0.59359237
100TYK20.57231880
101PDK10.56572636
102ATM0.56411876
103ZAP700.55951619
104CAMK40.55376115
105MST1R0.53607174
106PLK40.53024351
107GSK3B0.52603708
108MELK0.52126244
109ATR0.52067453
110BRAF0.51217734
111MAPK140.51153644
112PRKAA20.49990669
113MAPK70.49634731
114STK100.49189314
115MAPK10.48975924
116MAPK100.48720182
117RPS6KB20.48607726
118ERBB20.47391638
119CDK10.46989630
120SIK10.46232055
121CSK0.46073734
122TBK10.45959499
123PAK20.45935002
124KSR10.45432382
125AKT10.44707262
126PRKCH0.44125558
127FES0.43968584
128ARAF0.43560390
129MATK0.43142268
130GSK3A0.42410573
131MAPK80.41434984
132MAPKAPK30.40919838
133PDGFRB0.40569710
134HCK0.38891421
135UHMK10.38524079
136GRK50.38449584
137RET0.38379397
138PRKG20.37914343
139SGK30.37487058
140MAPK40.37477952
141JAK20.36662585
142MAP3K80.35684083
143BLK0.34199957
144MAP2K60.33605614
145IRAK10.30567799
146MAP3K140.30408236

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043302.60485335
2Lysine degradation_Homo sapiens_hsa003102.15331424
3mRNA surveillance pathway_Homo sapiens_hsa030152.12405069
4Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.09593873
5Dorso-ventral axis formation_Homo sapiens_hsa043202.05587959
6mTOR signaling pathway_Homo sapiens_hsa041501.99828735
7Other glycan degradation_Homo sapiens_hsa005111.86357390
8RNA transport_Homo sapiens_hsa030131.70358076
9Thyroid hormone signaling pathway_Homo sapiens_hsa049191.70288305
10Basal cell carcinoma_Homo sapiens_hsa052171.67111424
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61907942
12Hedgehog signaling pathway_Homo sapiens_hsa043401.59383193
13Cell cycle_Homo sapiens_hsa041101.57401531
14Hippo signaling pathway_Homo sapiens_hsa043901.56639381
15Longevity regulating pathway - mammal_Homo sapiens_hsa042111.54762901
16Chronic myeloid leukemia_Homo sapiens_hsa052201.50795638
17Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48684691
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.48173252
19Adherens junction_Homo sapiens_hsa045201.45355520
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.41544509
21Endometrial cancer_Homo sapiens_hsa052131.39407477
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38445168
23TGF-beta signaling pathway_Homo sapiens_hsa043501.37784220
24Osteoclast differentiation_Homo sapiens_hsa043801.37602379
25Circadian rhythm_Homo sapiens_hsa047101.37243430
26Renal cell carcinoma_Homo sapiens_hsa052111.35005350
27MicroRNAs in cancer_Homo sapiens_hsa052061.32367471
28Spliceosome_Homo sapiens_hsa030401.32155581
29Small cell lung cancer_Homo sapiens_hsa052221.32006526
30Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.29947987
31Colorectal cancer_Homo sapiens_hsa052101.28918079
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26397694
33Wnt signaling pathway_Homo sapiens_hsa043101.24214445
34Choline metabolism in cancer_Homo sapiens_hsa052311.23527424
35Prolactin signaling pathway_Homo sapiens_hsa049171.23380066
36Fatty acid biosynthesis_Homo sapiens_hsa000611.23001486
37T cell receptor signaling pathway_Homo sapiens_hsa046601.22980784
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19295720
39VEGF signaling pathway_Homo sapiens_hsa043701.17455462
40Prion diseases_Homo sapiens_hsa050201.14307997
41Acute myeloid leukemia_Homo sapiens_hsa052211.14180347
42Vitamin B6 metabolism_Homo sapiens_hsa007501.13296779
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.12807978
44Estrogen signaling pathway_Homo sapiens_hsa049151.12333949
45RNA polymerase_Homo sapiens_hsa030201.10967887
46Pancreatic cancer_Homo sapiens_hsa052121.09319183
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09053217
48Non-small cell lung cancer_Homo sapiens_hsa052231.06753633
49p53 signaling pathway_Homo sapiens_hsa041151.05757980
50Type II diabetes mellitus_Homo sapiens_hsa049301.04517430
51Fanconi anemia pathway_Homo sapiens_hsa034601.03246802
52Sulfur relay system_Homo sapiens_hsa041221.02867411
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.99943170
54Herpes simplex infection_Homo sapiens_hsa051680.99053568
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98376643
56Insulin resistance_Homo sapiens_hsa049310.98191037
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97213868
58Leishmaniasis_Homo sapiens_hsa051400.97115520
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.96870293
60Oocyte meiosis_Homo sapiens_hsa041140.96173577
61FoxO signaling pathway_Homo sapiens_hsa040680.96083461
62Aldosterone synthesis and secretion_Homo sapiens_hsa049250.95766446
63ErbB signaling pathway_Homo sapiens_hsa040120.94961246
64GnRH signaling pathway_Homo sapiens_hsa049120.93496900
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.93400350
66Hepatitis C_Homo sapiens_hsa051600.91810285
67Pathways in cancer_Homo sapiens_hsa052000.90435307
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.90306036
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90237053
70Insulin signaling pathway_Homo sapiens_hsa049100.89635404
71Basal transcription factors_Homo sapiens_hsa030220.89298249
72Prostate cancer_Homo sapiens_hsa052150.88401217
73MAPK signaling pathway_Homo sapiens_hsa040100.87225160
74Proteoglycans in cancer_Homo sapiens_hsa052050.86027799
75RNA degradation_Homo sapiens_hsa030180.86021619
76HTLV-I infection_Homo sapiens_hsa051660.85736272
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.85524616
78TNF signaling pathway_Homo sapiens_hsa046680.84835055
79AMPK signaling pathway_Homo sapiens_hsa041520.84531911
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83178658
81Bladder cancer_Homo sapiens_hsa052190.81931826
82Chemokine signaling pathway_Homo sapiens_hsa040620.80919075
83Thyroid cancer_Homo sapiens_hsa052160.80223308
84Fructose and mannose metabolism_Homo sapiens_hsa000510.79531432
85B cell receptor signaling pathway_Homo sapiens_hsa046620.79347468
86Glioma_Homo sapiens_hsa052140.79305317
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.78639360
88Tight junction_Homo sapiens_hsa045300.76575961
89Leukocyte transendothelial migration_Homo sapiens_hsa046700.76384960
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76383998
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76269171
92Cholinergic synapse_Homo sapiens_hsa047250.75606882
93Inositol phosphate metabolism_Homo sapiens_hsa005620.75125985
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74895074
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73602293
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73239028
97Influenza A_Homo sapiens_hsa051640.70783709
98Endocytosis_Homo sapiens_hsa041440.69970839
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68777197
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67090674
101Tuberculosis_Homo sapiens_hsa051520.66923764
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66841513
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.65541075
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.64611787
105Pentose phosphate pathway_Homo sapiens_hsa000300.64334909
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.64046350
107Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63865943
108HIF-1 signaling pathway_Homo sapiens_hsa040660.63451691
109Epstein-Barr virus infection_Homo sapiens_hsa051690.63308739
110Platelet activation_Homo sapiens_hsa046110.63051911
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62375557
112Gap junction_Homo sapiens_hsa045400.62139575
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60255864
114Rap1 signaling pathway_Homo sapiens_hsa040150.60097870
115Axon guidance_Homo sapiens_hsa043600.59373052
116cAMP signaling pathway_Homo sapiens_hsa040240.58720420
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.57861354
118Gastric acid secretion_Homo sapiens_hsa049710.57235238
119cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56518996
120Melanogenesis_Homo sapiens_hsa049160.55832738
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55420934
122Glucagon signaling pathway_Homo sapiens_hsa049220.54875203
123Focal adhesion_Homo sapiens_hsa045100.53415519
124Base excision repair_Homo sapiens_hsa034100.53117548
125Cocaine addiction_Homo sapiens_hsa050300.53040866
126Amoebiasis_Homo sapiens_hsa051460.52346244
127Toxoplasmosis_Homo sapiens_hsa051450.52252882
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.52122493
129Long-term potentiation_Homo sapiens_hsa047200.51644836
130Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51237843
131Ovarian steroidogenesis_Homo sapiens_hsa049130.50752566
132Apoptosis_Homo sapiens_hsa042100.49657678
133Hepatitis B_Homo sapiens_hsa051610.49389240
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48695647
135Oxytocin signaling pathway_Homo sapiens_hsa049210.48190625
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47809198
137Viral carcinogenesis_Homo sapiens_hsa052030.47534656

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