FBXL12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of gamma-delta T cell differentiation (GO:0045586)6.65653976
2positive regulation of gamma-delta T cell activation (GO:0046645)6.60725118
3regulation of gamma-delta T cell activation (GO:0046643)5.98504392
4V(D)J recombination (GO:0033151)5.86423662
5DNA deamination (GO:0045006)5.57223057
6positive T cell selection (GO:0043368)4.88099132
7T cell selection (GO:0045058)4.63979417
8negative regulation of thymocyte apoptotic process (GO:0070244)4.55037047
9positive thymic T cell selection (GO:0045059)4.51054915
10negative T cell selection (GO:0043383)4.41428786
11positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.38725407
12pseudouridine synthesis (GO:0001522)4.33341412
13negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.30910562
14negative regulation of telomere maintenance (GO:0032205)4.30644205
15negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.20813850
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.16851100
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.16851100
18positive regulation of defense response to virus by host (GO:0002230)4.11782997
19positive regulation of histone deacetylation (GO:0031065)4.11469987
20interferon-gamma production (GO:0032609)4.07033134
21regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.04846065
22regulation of histone H3-K27 methylation (GO:0061085)3.99063942
23negative regulation of cell killing (GO:0031342)3.98759472
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.98759472
25antigen processing and presentation of endogenous antigen (GO:0019883)3.84799091
26T cell receptor signaling pathway (GO:0050852)3.84402832
27negative regulation of DNA-templated transcription, elongation (GO:0032785)3.84038425
28thymic T cell selection (GO:0045061)3.83908637
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.80378758
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.80378758
31NADH dehydrogenase complex assembly (GO:0010257)3.80378758
32B cell receptor signaling pathway (GO:0050853)3.76267014
33negative regulation of histone methylation (GO:0031061)3.68271705
34antigen receptor-mediated signaling pathway (GO:0050851)3.67794917
35positive regulation of B cell differentiation (GO:0045579)3.64873617
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.64331211
37negative thymic T cell selection (GO:0045060)3.63249310
38mannosylation (GO:0097502)3.62960780
39regulation of retinoic acid receptor signaling pathway (GO:0048385)3.60919470
40positive regulation of gene expression, epigenetic (GO:0045815)3.58796806
41piRNA metabolic process (GO:0034587)3.42196194
42protein complex biogenesis (GO:0070271)3.40822726
43histone H3-K4 methylation (GO:0051568)3.37669841
44peptidyl-histidine modification (GO:0018202)3.33689252
45positive regulation of protein deacetylation (GO:0090312)3.33140396
46regulation of memory T cell differentiation (GO:0043380)3.31039321
47tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.30005964
48RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.30005964
49cellular hyperosmotic response (GO:0071474)3.29253440
50regulation of defense response to virus by host (GO:0050691)3.28268778
51regulation of B cell differentiation (GO:0045577)3.27908847
52histone H4-K16 acetylation (GO:0043984)3.27572907
53regulation of T cell tolerance induction (GO:0002664)3.25912969
54positive regulation of interleukin-2 production (GO:0032743)3.24466571
55positive regulation of protein homooligomerization (GO:0032464)3.23696741
56somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.19984712
57somatic cell DNA recombination (GO:0016444)3.19984712
58Peyers patch development (GO:0048541)3.17461991
59mucosal-associated lymphoid tissue development (GO:0048537)3.17461991
60mitochondrial respiratory chain complex assembly (GO:0033108)3.16449975
61platelet dense granule organization (GO:0060155)3.16123703
62base-excision repair, AP site formation (GO:0006285)3.14403296
63regulation of thymocyte apoptotic process (GO:0070243)3.13896737
64negative regulation of erythrocyte differentiation (GO:0045647)3.12722375
65histone H3-K4 trimethylation (GO:0080182)3.11382094
66ubiquinone biosynthetic process (GO:0006744)3.08749664
67protein localization to kinetochore (GO:0034501)3.08087532
68T cell homeostasis (GO:0043029)3.07905341
69T cell differentiation (GO:0030217)3.06423485
70adaptation of signaling pathway (GO:0023058)3.05382947
71negative regulation of telomerase activity (GO:0051974)3.04977843
72T cell costimulation (GO:0031295)3.04344955
73cytidine metabolic process (GO:0046087)3.02895678
74cytidine catabolic process (GO:0006216)3.02895678
75cytidine deamination (GO:0009972)3.02895678
76protein localization to chromosome, centromeric region (GO:0071459)3.02368331
77regulation of histone H3-K9 methylation (GO:0051570)3.01399798
78lymphocyte costimulation (GO:0031294)2.97433408
79water-soluble vitamin biosynthetic process (GO:0042364)2.95804586
80tRNA processing (GO:0008033)2.95424540
81regulation of regulatory T cell differentiation (GO:0045589)2.95271937
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.94649160
83male meiosis I (GO:0007141)2.94326900
84iron-sulfur cluster assembly (GO:0016226)2.94294679
85metallo-sulfur cluster assembly (GO:0031163)2.94294679
86regulation of interleukin-2 biosynthetic process (GO:0045076)2.93434502
87positive regulation of prostaglandin secretion (GO:0032308)2.93320840
88somatic diversification of immune receptors (GO:0002200)2.93220843
89histone H4-K8 acetylation (GO:0043982)2.92742565
90histone H4-K5 acetylation (GO:0043981)2.92742565
91ubiquinone metabolic process (GO:0006743)2.91394093
92regulation of B cell receptor signaling pathway (GO:0050855)2.91234102
93nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89375534
94mitochondrial RNA metabolic process (GO:0000959)2.89219762
95negative regulation of gene silencing (GO:0060969)2.88505026
96pre-miRNA processing (GO:0031054)2.88386186
97fucose catabolic process (GO:0019317)2.87564564
98L-fucose metabolic process (GO:0042354)2.87564564
99L-fucose catabolic process (GO:0042355)2.87564564
100activated T cell proliferation (GO:0050798)2.86589810
101regulation of histone H3-K4 methylation (GO:0051569)2.86326522
102protein-DNA complex disassembly (GO:0032986)2.85296589
103nucleosome disassembly (GO:0006337)2.85296589
104chaperone-mediated protein transport (GO:0072321)2.84595158
105rRNA modification (GO:0000154)2.82632165
106NIK/NF-kappaB signaling (GO:0038061)2.82147295
107positive regulation by host of viral transcription (GO:0043923)2.81939533
108natural killer cell differentiation (GO:0001779)2.81180323
109sister chromatid segregation (GO:0000819)2.79298553
110modulation by virus of host process (GO:0019054)2.78637102
111positive regulation of granulocyte differentiation (GO:0030854)2.77750057
112heterochromatin organization (GO:0070828)2.77631840
113morphogenesis of an endothelium (GO:0003159)2.76714402
114endothelial tube morphogenesis (GO:0061154)2.76714402
115negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.75806505
116mitotic chromosome condensation (GO:0007076)2.74332710
117response to interleukin-15 (GO:0070672)2.74194465
118negative regulation of mast cell activation (GO:0033004)2.74126116
119negative regulation of T cell apoptotic process (GO:0070233)2.73508736
120mitotic sister chromatid segregation (GO:0000070)2.73263391
121regulation of T cell receptor signaling pathway (GO:0050856)2.72862542
122regulation of telomere maintenance via telomerase (GO:0032210)2.72156262
123regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72096711
124regulation of histone methylation (GO:0031060)2.72067327
125regulation of interleukin-12 biosynthetic process (GO:0045075)2.71673217
126positive regulation of activated T cell proliferation (GO:0042104)2.68873373
127chromatin assembly (GO:0031497)2.68046702
128protein polyglutamylation (GO:0018095)2.66967879
129immune response-activating cell surface receptor signaling pathway (GO:0002429)2.66927832
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66894202
131regulation of interleukin-2 production (GO:0032663)2.66602319
132positive regulation of mitochondrial fission (GO:0090141)2.66112340
133negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.65660944
134lymphocyte homeostasis (GO:0002260)2.65465135
135proteasome assembly (GO:0043248)2.65120862
136viral transcription (GO:0019083)2.64999632
137regulation of chromatin silencing (GO:0031935)2.64628501
138regulation of telomerase activity (GO:0051972)2.64032372
139T cell differentiation in thymus (GO:0033077)2.63616846
140pyrimidine ribonucleoside catabolic process (GO:0046133)2.63202612
141histone H4-K12 acetylation (GO:0043983)2.62568084
142ribosomal small subunit biogenesis (GO:0042274)2.61979946
143alpha-beta T cell activation (GO:0046631)2.61299836
144negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.58926694
145histone H4 deacetylation (GO:0070933)2.58792896
146positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.58588863
147positive regulation of tolerance induction (GO:0002645)2.57370061
148mRNA stabilization (GO:0048255)2.55821811
149RNA stabilization (GO:0043489)2.55821811
150regulation of mitochondrial translation (GO:0070129)2.55554811
1513-UTR-mediated mRNA stabilization (GO:0070935)2.55259643
152DNA damage induced protein phosphorylation (GO:0006975)2.54570916
153preassembly of GPI anchor in ER membrane (GO:0016254)2.54183057
154negative regulation of RNA splicing (GO:0033119)2.53730868
155histone H3 acetylation (GO:0043966)2.53461307
156tRNA modification (GO:0006400)2.53090564
157tRNA metabolic process (GO:0006399)2.52592197
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.52120423
159antigen processing and presentation via MHC class Ib (GO:0002475)2.51558730
160mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51527197
161pyrimidine nucleotide catabolic process (GO:0006244)2.51462033
162deoxyribonucleotide catabolic process (GO:0009264)2.50803482
163DNA methylation involved in gamete generation (GO:0043046)2.50048175
164negative regulation of gene expression, epigenetic (GO:0045814)2.49376213
165meiosis I (GO:0007127)2.49326528
166short-chain fatty acid metabolic process (GO:0046459)2.49300271
167positive regulation of interleukin-17 production (GO:0032740)2.47882986
168DNA replication checkpoint (GO:0000076)2.46061719
169DNA demethylation (GO:0080111)2.46046985
170mast cell degranulation (GO:0043303)2.44213681
171mast cell activation involved in immune response (GO:0002279)2.44213681
172transcription elongation from RNA polymerase III promoter (GO:0006385)2.40221183
173termination of RNA polymerase III transcription (GO:0006386)2.40221183
174autophagic vacuole fusion (GO:0000046)2.39883207
175purine deoxyribonucleotide catabolic process (GO:0009155)2.38889190
176regulation of helicase activity (GO:0051095)2.32683799
177rRNA transcription (GO:0009303)2.32355957
178DNA catabolic process, exonucleolytic (GO:0000738)2.31740746
179regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.31654808
180cellular response to interferon-beta (GO:0035458)2.31401391
181pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.31200773
182cytokine biosynthetic process (GO:0042089)2.31044285
183quinone biosynthetic process (GO:1901663)2.30730873
184GPI anchor metabolic process (GO:0006505)2.30604987
185behavioral response to nicotine (GO:0035095)2.30563012
186somatic hypermutation of immunoglobulin genes (GO:0016446)2.29284170
187somatic diversification of immune receptors via somatic mutation (GO:0002566)2.29284170
188positive regulation of lymphocyte apoptotic process (GO:0070230)2.27307395
189GPI anchor biosynthetic process (GO:0006506)2.26770902
190pyrimidine dimer repair (GO:0006290)2.25557954
191respiratory chain complex IV assembly (GO:0008535)2.24940983
192positive regulation of T-helper cell differentiation (GO:0045624)2.23603982
193regulation of prostaglandin secretion (GO:0032306)2.23173431
194DNA modification (GO:0006304)2.22953294
195meiotic chromosome segregation (GO:0045132)2.22535804
196ncRNA processing (GO:0034470)2.22523986
197protein targeting to mitochondrion (GO:0006626)2.22422070
198deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.22394107
199RNA modification (GO:0009451)2.22161343

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human4.51591448
2E2F7_22180533_ChIP-Seq_HELA_Human4.31958692
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.78177024
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.77954154
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.56977725
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.56415392
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.51817982
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.26957188
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.20626600
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14466351
11VDR_21846776_ChIP-Seq_THP-1_Human3.11428546
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.05447472
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.02753728
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01200936
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.98424391
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.80021874
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64762992
18UTX_26944678_Chip-Seq_JUKART_Human2.63486074
19TCF7_22412390_ChIP-Seq_EML_Mouse2.62910149
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.60411190
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45465429
22MAF_26560356_Chip-Seq_TH1_Human2.38943535
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.38128183
24* GABP_19822575_ChIP-Seq_HepG2_Human2.36188649
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.34771308
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.26615870
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25557828
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25091172
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24808851
30* MYB_26560356_Chip-Seq_TH2_Human2.24195786
31TP63_19390658_ChIP-ChIP_HaCaT_Human2.21043680
32KDM2B_26808549_Chip-Seq_DND41_Human2.19065171
33CIITA_25753668_ChIP-Seq_RAJI_Human2.17608227
34ZNF274_21170338_ChIP-Seq_K562_Hela2.17164734
35MYB_26560356_Chip-Seq_TH1_Human2.15404672
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.15226442
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.14331931
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.10675397
39* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.09607041
40RUNX_20019798_ChIP-Seq_JUKART_Human2.09393602
41KDM2B_26808549_Chip-Seq_SUP-B15_Human2.08959685
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07140133
43SCL_19346495_ChIP-Seq_HPC-7_Human2.05062015
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04769548
45YY1_21170310_ChIP-Seq_MESCs_Mouse2.03182360
46THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02908264
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.02419685
48* MYC_18940864_ChIP-ChIP_HL60_Human1.95632040
49* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.91030400
50ELK3_25401928_ChIP-Seq_HUVEC_Human1.86057424
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83721605
52IRF1_19129219_ChIP-ChIP_H3396_Human1.81651243
53* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80530496
54TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80047465
55VDR_24763502_ChIP-Seq_THP-1_Human1.77033471
56DCP1A_22483619_ChIP-Seq_HELA_Human1.75320394
57MAF_26560356_Chip-Seq_TH2_Human1.72276677
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71490980
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.70330789
60IRF8_22096565_ChIP-ChIP_GC-B_Human1.69918992
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.67041396
62ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66343275
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.66115315
64TTF2_22483619_ChIP-Seq_HELA_Human1.64420833
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.60788437
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60336799
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.59844250
68EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58038325
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.54743280
70NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53453749
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.50360229
72BRD4_27068464_Chip-Seq_AML-cells_Mouse1.46048756
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45434497
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.45223349
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.44161833
76LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40987280
77* GATA3_27048872_Chip-Seq_THYMUS_Human1.40606155
78* SPI1_23547873_ChIP-Seq_NB4_Human1.39609296
79BCL6_27268052_Chip-Seq_Bcells_Human1.39538108
80NCOR1_26117541_ChIP-Seq_K562_Human1.36020097
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.34063235
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33717751
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30339724
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29856584
85ELK1_19687146_ChIP-ChIP_HELA_Human1.29383586
86KDM5A_27292631_Chip-Seq_BREAST_Human1.29366417
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29259437
88MYC_19079543_ChIP-ChIP_MESCs_Mouse1.25836708
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25810449
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25481651
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25252966
92SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24681701
93LXR_22292898_ChIP-Seq_THP-1_Human1.23779923
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.22726120
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21754469
96SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20432426
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19615967
98E2F1_20622854_ChIP-Seq_HELA_Human1.18335919
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.17582327
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17007011
101MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16741280
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16694559
103SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15375514
104XRN2_22483619_ChIP-Seq_HELA_Human1.14979869
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14615509
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14427845
107RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14334259
108YY1_22570637_ChIP-Seq_MALME-3M_Human1.13144079
109SPI1_23127762_ChIP-Seq_K562_Human1.12634212
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12585741
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.11293618
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10784482
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10544865
114TFEB_21752829_ChIP-Seq_HELA_Human1.10492553
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09243238
116BP1_19119308_ChIP-ChIP_Hs578T_Human1.09122227
117BCOR_27268052_Chip-Seq_Bcells_Human1.08491227
118DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06811612
119FOXP3_21729870_ChIP-Seq_TREG_Human1.05908307
120GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05602238
121IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05136570
122PHF8_20622854_ChIP-Seq_HELA_Human1.05053411
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.04146854
124HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03126950
125ZFP281_27345836_Chip-Seq_ESCs_Mouse1.02311801
126ERA_21632823_ChIP-Seq_H3396_Human1.01124857
127KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00623915
128MYC_18555785_ChIP-Seq_MESCs_Mouse1.00182431
129VDR_23849224_ChIP-Seq_CD4+_Human1.00178211
130GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00111432
131RACK7_27058665_Chip-Seq_MCF-7_Human0.99936979
132P68_20966046_ChIP-Seq_HELA_Human0.99058525
133POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98514166
134IRF8_27001747_Chip-Seq_BMDM_Mouse0.97646157
135* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96868455
136PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96734111
137PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95204068
138LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94836190
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.94719219
140ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94307120
141MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94290267
142NANOG_21062744_ChIP-ChIP_HESCs_Human0.94276639
143CTCF_26484167_Chip-Seq_Bcells_Mouse0.93271850
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92369703
145CTCF_21964334_Chip-Seq_Bcells_Human0.91726832
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91595656
147CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91499245
148E2F1_21310950_ChIP-Seq_MCF-7_Human0.90827611
149P300_27268052_Chip-Seq_Bcells_Human0.90805751
150EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90275654
151CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90145244
152* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.88677915
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87235069
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87204211
155KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86671232
156NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85735695
157SA1_27219007_Chip-Seq_ERYTHROID_Human0.84820081
158* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84468096
159ELF1_20517297_ChIP-Seq_JURKAT_Human0.84357609

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color3.94749969
2MP0003763_abnormal_thymus_physiology3.80898689
3MP0000685_abnormal_immune_system3.10513859
4MP0000703_abnormal_thymus_morphology2.85113590
5MP0005671_abnormal_response_to2.81944613
6MP0001800_abnormal_humoral_immune2.73119055
7MP0003646_muscle_fatigue2.70817066
8MP0002396_abnormal_hematopoietic_system2.64969684
9MP0000372_irregular_coat_pigmentation2.62376449
10MP0009278_abnormal_bone_marrow2.59545879
11MP0002398_abnormal_bone_marrow2.57330028
12MP0000015_abnormal_ear_pigmentation2.43830905
13MP0005387_immune_system_phenotype2.43393909
14MP0001790_abnormal_immune_system2.43393909
15MP0002166_altered_tumor_susceptibility2.43147729
16MP0008995_early_reproductive_senescence2.30747808
17MP0001835_abnormal_antigen_presentation2.26053514
18MP0003786_premature_aging2.24909067
19MP0006292_abnormal_olfactory_placode2.24785324
20MP0010352_gastrointestinal_tract_polyps2.21709361
21MP0004808_abnormal_hematopoietic_stem2.20096512
22MP0002722_abnormal_immune_system2.20051867
23MP0000689_abnormal_spleen_morphology2.16522967
24MP0002102_abnormal_ear_morphology2.16089422
25MP0002163_abnormal_gland_morphology2.13073523
26MP0000716_abnormal_immune_system2.12606036
27MP0004947_skin_inflammation2.05972998
28MP0002420_abnormal_adaptive_immunity2.02852312
29MP0009333_abnormal_splenocyte_physiolog2.00187846
30MP0001819_abnormal_immune_cell1.98984013
31MP0002452_abnormal_antigen_presenting1.98092870
32MP0010094_abnormal_chromosome_stability1.96959093
33MP0008057_abnormal_DNA_replication1.93974444
34MP0002148_abnormal_hypersensitivity_rea1.93076114
35MP0002138_abnormal_hepatobiliary_system1.91121213
36MP0002723_abnormal_immune_serum1.90317200
37MP0009840_abnormal_foam_cell1.84915163
38MP0001764_abnormal_homeostasis1.84081960
39MP0003077_abnormal_cell_cycle1.81905044
40MP0005171_absent_coat_pigmentation1.81882173
41MP0002405_respiratory_system_inflammati1.81529542
42MP0002429_abnormal_blood_cell1.81223569
43MP0009764_decreased_sensitivity_to1.78891882
44MP0003186_abnormal_redox_activity1.77236914
45MP0010155_abnormal_intestine_physiology1.75334158
46MP0002132_abnormal_respiratory_system1.71077996
47MP0005000_abnormal_immune_tolerance1.71059370
48MP0003303_peritoneal_inflammation1.70417520
49MP0002638_abnormal_pupillary_reflex1.69307302
50MP0001849_ear_inflammation1.68252381
51MP0008961_abnormal_basal_metabolism1.67277518
52MP0008789_abnormal_olfactory_epithelium1.66735743
53MP0002006_tumorigenesis1.59719134
54MP0003300_gastrointestinal_ulcer1.59617724
55MP0004957_abnormal_blastocyst_morpholog1.58263093
56MP0005076_abnormal_cell_differentiation1.58179081
57MP0003111_abnormal_nucleus_morphology1.57755028
58MP0005397_hematopoietic_system_phenotyp1.57332202
59MP0001545_abnormal_hematopoietic_system1.57332202
60MP0003693_abnormal_embryo_hatching1.54657725
61MP0009384_cardiac_valve_regurgitation1.51457730
62MP0009785_altered_susceptibility_to1.48772432
63MP0008007_abnormal_cellular_replicative1.47746877
64MP0001529_abnormal_vocalization1.43711652
65MP0004133_heterotaxia1.43497317
66MP0002653_abnormal_ependyma_morphology1.40284860
67MP0003195_calcinosis1.38599801
68MP0005058_abnormal_lysosome_morphology1.37802078
69MP0000490_abnormal_crypts_of1.36964899
70MP0005084_abnormal_gallbladder_morpholo1.34725722
71MP0000465_gastrointestinal_hemorrhage1.34329076
72MP0000350_abnormal_cell_proliferation1.34300060
73MP0006054_spinal_hemorrhage1.33816739
74MP0002019_abnormal_tumor_incidence1.30707307
75MP0000343_altered_response_to1.30279641
76MP0003705_abnormal_hypodermis_morpholog1.30069517
77MP0004264_abnormal_extraembryonic_tissu1.28717899
78MP0003436_decreased_susceptibility_to1.26098298
79MP0002419_abnormal_innate_immunity1.25213444
80MP0003806_abnormal_nucleotide_metabolis1.24308821
81MP0005025_abnormal_response_to1.23756606
82MP0005389_reproductive_system_phenotype1.21771126
83MP0002938_white_spotting1.21201676
84MP0006082_CNS_inflammation1.19446749
85MP0000049_abnormal_middle_ear1.18464524
86MP0002210_abnormal_sex_determination1.17910812
87MP0002933_joint_inflammation1.17241334
88MP0003866_abnormal_defecation1.15296926
89MP0002837_dystrophic_cardiac_calcinosis1.14310740
90MP0006036_abnormal_mitochondrial_physio1.13364949
91MP0008877_abnormal_DNA_methylation1.13283265
92MP0008875_abnormal_xenobiotic_pharmacok1.10206381
93MP0005464_abnormal_platelet_physiology1.08813603
94MP0001879_abnormal_lymphatic_vessel1.06800303
95MP0005023_abnormal_wound_healing1.06749478
96MP0005409_darkened_coat_color1.06138911
97MP0001853_heart_inflammation1.02442407
98MP0005380_embryogenesis_phenotype1.01539546
99MP0001672_abnormal_embryogenesis/_devel1.01539546
100MP0001730_embryonic_growth_arrest1.00462776
101MP0003984_embryonic_growth_retardation0.99503543
102MP0002088_abnormal_embryonic_growth/wei0.99309596
103MP0001873_stomach_inflammation0.98642504
104MP0001145_abnormal_male_reproductive0.97754450
105MP0006276_abnormal_autonomic_nervous0.97344174
106MP0002160_abnormal_reproductive_system0.97052696
107MP0008932_abnormal_embryonic_tissue0.96875014
108MP0001845_abnormal_inflammatory_respons0.96613708
109MP0000313_abnormal_cell_death0.93988562
110MP0008058_abnormal_DNA_repair0.93740840
111MP0002086_abnormal_extraembryonic_tissu0.93315811
112MP0001919_abnormal_reproductive_system0.92641853
113MP0002092_abnormal_eye_morphology0.92585133
114MP0005645_abnormal_hypothalamus_physiol0.92496205
115MP0002876_abnormal_thyroid_physiology0.92426838
116MP0001929_abnormal_gametogenesis0.90536347
117MP0001697_abnormal_embryo_size0.88314938
118MP0002277_abnormal_respiratory_mucosa0.87201884
119MP0008469_abnormal_protein_level0.86839699
120MP0004197_abnormal_fetal_growth/weight/0.86689718
121MP0001119_abnormal_female_reproductive0.86629237
122MP0005379_endocrine/exocrine_gland_phen0.86405516
123MP0000858_altered_metastatic_potential0.84426161
124MP0000653_abnormal_sex_gland0.83552470
125MP0003718_maternal_effect0.82256222
126MP0001324_abnormal_eye_pigmentation0.82190786
127MP0004510_myositis0.82091705
128MP0002085_abnormal_embryonic_tissue0.81884153
129MP0002080_prenatal_lethality0.81142443
130MP0005646_abnormal_pituitary_gland0.80165989
131MP0006072_abnormal_retinal_apoptosis0.79470875
132MP0002970_abnormal_white_adipose0.79182417
133MP0003453_abnormal_keratinocyte_physiol0.78725654
134MP0005075_abnormal_melanosome_morpholog0.78393126
135MP0005310_abnormal_salivary_gland0.78173807
136MP0005174_abnormal_tail_pigmentation0.77607587
137MP0004381_abnormal_hair_follicle0.77287435
138MP0002925_abnormal_cardiovascular_devel0.76808391
139MP0002127_abnormal_cardiovascular_syste0.76411749
140MP0008260_abnormal_autophagy0.75586795
141MP0008770_decreased_survivor_rate0.74386641
142MP0002084_abnormal_developmental_patter0.74380699
143MP0002075_abnormal_coat/hair_pigmentati0.74372088
144MP0000733_abnormal_muscle_development0.74115505
145MP0002095_abnormal_skin_pigmentation0.71634841
146MP0003943_abnormal_hepatobiliary_system0.71628227
147MP0000477_abnormal_intestine_morphology0.70178892
148MP0001216_abnormal_epidermal_layer0.69477896
149MP0003121_genomic_imprinting0.68858943
150MP0010630_abnormal_cardiac_muscle0.68773804
151MP0004185_abnormal_adipocyte_glucose0.68771698
152MP0003828_pulmonary_edema0.67055185
153MP0005394_taste/olfaction_phenotype0.66757800
154MP0005499_abnormal_olfactory_system0.66757800

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of B cell number (HP:0010975)6.73410279
2B lymphocytopenia (HP:0010976)6.73410279
3T lymphocytopenia (HP:0005403)6.32337003
4Panhypogammaglobulinemia (HP:0003139)6.09543523
5Abnormality of T cell number (HP:0011839)5.90867180
6Severe combined immunodeficiency (HP:0004430)5.82440433
7Combined immunodeficiency (HP:0005387)5.80919149
8Thyroiditis (HP:0100646)5.65117807
9Recurrent viral infections (HP:0004429)5.02303219
10Hypoplasia of the thymus (HP:0000778)4.72283675
11Eosinophilia (HP:0001880)4.43097296
12Severe visual impairment (HP:0001141)4.20317031
13Agammaglobulinemia (HP:0004432)3.82145789
14Abnormality of T cells (HP:0002843)3.79726207
15Granulocytopenia (HP:0001913)3.70605551
16Hypoproteinemia (HP:0003075)3.68553708
17Abnormality of the fingertips (HP:0001211)3.66491162
18Abnormality of eosinophils (HP:0001879)3.65069810
19Recurrent fungal infections (HP:0002841)3.62656551
20Verrucae (HP:0200043)3.35163688
21Papilloma (HP:0012740)3.35163688
22Recurrent bronchitis (HP:0002837)3.29327713
23Abnormality of DNA repair (HP:0003254)3.27047071
24Albinism (HP:0001022)3.20244446
25Retinal dysplasia (HP:0007973)3.13277975
26Nasal polyposis (HP:0100582)3.10145992
27Type II lissencephaly (HP:0007260)3.09166844
28Hepatocellular necrosis (HP:0001404)2.94713867
29Abnormality of midbrain morphology (HP:0002418)2.93449776
30Molar tooth sign on MRI (HP:0002419)2.93449776
31True hermaphroditism (HP:0010459)2.93056950
32Abnormality of the nasal mucosa (HP:0000433)2.92300107
33Meningitis (HP:0001287)2.92174700
34IgG deficiency (HP:0004315)2.92103987
35Hyperglycinemia (HP:0002154)2.91413478
36Mitochondrial inheritance (HP:0001427)2.91212260
37Cellulitis (HP:0100658)2.89238628
38Abnormal delayed hypersensitivity skin test (HP:0002963)2.88870129
39Leukocytosis (HP:0001974)2.84137808
40Volvulus (HP:0002580)2.75078894
41Decreased electroretinogram (ERG) amplitude (HP:0000654)2.74723577
42Increased serum lactate (HP:0002151)2.73576958
43Increased IgM level (HP:0003496)2.71452817
44Acute necrotizing encephalopathy (HP:0006965)2.70843708
45Basal cell carcinoma (HP:0002671)2.69739711
46Methylmalonic aciduria (HP:0012120)2.64918638
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.62634849
48Abnormality of alanine metabolism (HP:0010916)2.62634849
49Hyperalaninemia (HP:0003348)2.62634849
50Acute encephalopathy (HP:0006846)2.61774092
51Cutaneous melanoma (HP:0012056)2.61382751
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60604741
53Long eyelashes (HP:0000527)2.59246950
54Increased CSF lactate (HP:0002490)2.57875067
55Gastrointestinal inflammation (HP:0004386)2.55289033
56Abnormality of the intervertebral disk (HP:0005108)2.53767995
57Abnormal mitochondria in muscle tissue (HP:0008316)2.52620323
58Pancreatic cysts (HP:0001737)2.52351997
59Abnormal protein glycosylation (HP:0012346)2.51672607
60Abnormal glycosylation (HP:0012345)2.51672607
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.51672607
62Abnormal protein N-linked glycosylation (HP:0012347)2.51672607
63Hypoplasia of the pons (HP:0012110)2.51431594
64Aplasia/Hypoplasia of the thymus (HP:0010515)2.51186863
65Inflammation of the large intestine (HP:0002037)2.50437833
66Colitis (HP:0002583)2.49540054
67Entropion (HP:0000621)2.47078309
68Decreased activity of mitochondrial respiratory chain (HP:0008972)2.45501600
69Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.45501600
70Chronic otitis media (HP:0000389)2.43000385
71Hepatic necrosis (HP:0002605)2.41457408
72IgM deficiency (HP:0002850)2.41411178
73Acute lymphatic leukemia (HP:0006721)2.41167487
74Neutropenia (HP:0001875)2.40218192
75Pendular nystagmus (HP:0012043)2.38645126
76Methylmalonic acidemia (HP:0002912)2.36604203
77Cerebellar dysplasia (HP:0007033)2.33283239
78Abnormality of the pons (HP:0007361)2.31429999
79Rib fusion (HP:0000902)2.30189825
80Lymphoma (HP:0002665)2.29605501
81Sparse lateral eyebrow (HP:0005338)2.28194949
82Pancytopenia (HP:0001876)2.27364400
83Reticulocytopenia (HP:0001896)2.27254392
84Hypochromic anemia (HP:0001931)2.26667701
85Type I transferrin isoform profile (HP:0003642)2.26634288
86Depressed nasal tip (HP:0000437)2.25671477
87Pustule (HP:0200039)2.24967252
88Nephronophthisis (HP:0000090)2.24817373
89Vacuolated lymphocytes (HP:0001922)2.21467418
90Recurrent sinusitis (HP:0011108)2.19913543
91Abolished electroretinogram (ERG) (HP:0000550)2.16147023
92Bronchitis (HP:0012387)2.15261087
93Hypoplasia of the fovea (HP:0007750)2.14906392
94Aplasia/Hypoplasia of the fovea (HP:0008060)2.14906392
95Poikiloderma (HP:0001029)2.14627069
96Abnormality of the ileum (HP:0001549)2.14281430
97Sepsis (HP:0100806)2.14066497
98Abnormality of glycine metabolism (HP:0010895)2.14009049
99Abnormality of serine family amino acid metabolism (HP:0010894)2.14009049
100Lymphopenia (HP:0001888)2.13850951
101Absent rod-and cone-mediated responses on ERG (HP:0007688)2.13218856
102Meckel diverticulum (HP:0002245)2.13094885
103Microretrognathia (HP:0000308)2.12629704
104Abnormality of cells of the lymphoid lineage (HP:0012140)2.12362626
105Pancreatic fibrosis (HP:0100732)2.11103816
1063-Methylglutaconic aciduria (HP:0003535)2.10630008
107Sclerocornea (HP:0000647)2.10188955
108Lactic acidosis (HP:0003128)2.10177933
109Recurrent otitis media (HP:0000403)2.09596066
110Chromosomal breakage induced by crosslinking agents (HP:0003221)2.08253926
111Hyperglycinuria (HP:0003108)2.05824642
112Mesangial abnormality (HP:0001966)2.05466273
113Abnormality of the fovea (HP:0000493)2.05345552
114Hypoplasia of the uterus (HP:0000013)2.04537008
115Aplasia/hypoplasia of the uterus (HP:0008684)2.04166571
116Chronic mucocutaneous candidiasis (HP:0002728)2.04165042
117Recurrent cutaneous fungal infections (HP:0011370)2.04165042
118Microvesicular hepatic steatosis (HP:0001414)2.03830901
119Lip pit (HP:0100267)2.03535073
120Abnormality of the thymus (HP:0000777)2.03243592
121Progressive macrocephaly (HP:0004481)2.03185111
122Lipid accumulation in hepatocytes (HP:0006561)2.03023822
123Skin tags (HP:0010609)2.02794076
124Aplasia/Hypoplasia of the uvula (HP:0010293)2.00288746
125Autoimmune thrombocytopenia (HP:0001973)1.99581189
126Prolonged neonatal jaundice (HP:0006579)1.99514273
127Short tibia (HP:0005736)1.99096922
128Stomatitis (HP:0010280)1.98531449
129Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98439158
130Emphysema (HP:0002097)1.98293587
131Absent thumb (HP:0009777)1.98171313
132Chronic sinusitis (HP:0011109)1.95375782
133Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93975199
134Duplicated collecting system (HP:0000081)1.91735322
135Abnormality of dicarboxylic acid metabolism (HP:0010995)1.91441749
136Dicarboxylic aciduria (HP:0003215)1.91441749
137Progressive microcephaly (HP:0000253)1.90815222
138Progressive muscle weakness (HP:0003323)1.90473096
139Abnormality of the renal collecting system (HP:0004742)1.90292156
140Ependymoma (HP:0002888)1.89774147
141Abnormality of cells of the erythroid lineage (HP:0012130)1.88181210
142Congenital stationary night blindness (HP:0007642)1.88141120
143Bicuspid aortic valve (HP:0001647)1.88087504
144Increased muscle lipid content (HP:0009058)1.87479699
145Hyperacusis (HP:0010780)1.87041009
146Medulloblastoma (HP:0002885)1.86846980
147Preauricular skin tag (HP:0000384)1.86116065
148Anencephaly (HP:0002323)1.85313375
149Aplasia/Hypoplasia of the tibia (HP:0005772)1.83681489
150Increased intramyocellular lipid droplets (HP:0012240)1.83123614
151Hypoplastic pelvis (HP:0008839)1.82868439
152Medial flaring of the eyebrow (HP:0010747)1.82023440
153Aplastic anemia (HP:0001915)1.81885095
154Supernumerary ribs (HP:0005815)1.80934104
155Spontaneous hematomas (HP:0007420)1.80827991
156Carpal bone hypoplasia (HP:0001498)1.80292678
157Bony spicule pigmentary retinopathy (HP:0007737)1.79726561
158Elevated erythrocyte sedimentation rate (HP:0003565)1.79143918
159Blepharitis (HP:0000498)1.77678715
160Neoplasm of striated muscle (HP:0009728)1.76856368
161Abnormality of T cell physiology (HP:0011840)1.75863643
162Erythroderma (HP:0001019)1.75450467
163Cutis marmorata (HP:0000965)1.71207231
164Prominent nose (HP:0000448)1.69730879
165Prolonged bleeding time (HP:0003010)1.69685169
166Increased IgE level (HP:0003212)1.69459374
167Mitral regurgitation (HP:0001653)1.68952645
168Abnormal rod and cone electroretinograms (HP:0008323)1.67193248
169Gastrointestinal stroma tumor (HP:0100723)1.66930109
170Increased nuchal translucency (HP:0010880)1.66917762
171Anal stenosis (HP:0002025)1.65587217
172Cellular immunodeficiency (HP:0005374)1.64507141
173Heterotopia (HP:0002282)1.63822287
174Rhabdomyosarcoma (HP:0002859)1.61111962
175Hypochromic microcytic anemia (HP:0004840)1.59927406
176Long palpebral fissure (HP:0000637)1.58791940
177Supernumerary bones of the axial skeleton (HP:0009144)1.57284680
178Myositis (HP:0100614)1.55176582
179Sparse scalp hair (HP:0002209)1.54744101
180Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.54172202
181Abnormal number of erythroid precursors (HP:0012131)1.53891028
182Chest pain (HP:0100749)1.51725981
183Cheilitis (HP:0100825)1.51551831
184Macroorchidism (HP:0000053)1.51202570
185Abnormal platelet function (HP:0011869)1.50227324
186Impaired platelet aggregation (HP:0003540)1.50227324
187Encephalitis (HP:0002383)1.49810934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K105.04779066
2CDK123.98312420
3MAP4K13.92612499
4GRK63.65052732
5TAOK23.51396877
6TESK23.37529272
7VRK23.12839358
8ZAK3.04592557
9STK102.93333718
10ERN12.91665772
11BCKDK2.73817847
12EEF2K2.57882498
13TAOK32.32438749
14TXK2.13549034
15ADRBK22.09425146
16ITK2.08941328
17CDK192.07509045
18TGFBR21.93128433
19MAP4K21.81254260
20ZAP701.80723555
21ICK1.80493826
22SIK21.80328894
23FGFR41.80308276
24VRK11.78299903
25NME11.72718527
26NEK21.71781251
27NUAK11.69181301
28CSF1R1.66187900
29IRAK41.63454213
30PIM21.62620575
31RPS6KB21.62079407
32TYK21.59636905
33NME21.54456208
34MAP3K71.48146172
35BTK1.44473475
36RPS6KA41.39708808
37TRIB31.39300314
38MAPK71.36459023
39GRK71.34050063
40PDK21.31691375
41TYRO31.30025269
42HCK1.29904087
43MATK1.29801336
44CDK91.27117293
45SRPK11.25923988
46MARK21.25751833
47CSK1.25429358
48SYK1.24586966
49JAK31.24416840
50LRRK21.23801880
51CDK41.23599895
52MAP3K51.22942902
53PKN21.21543766
54FGFR31.19964017
55DYRK31.17802789
56HIPK21.16597575
57STK161.12969187
58MAP2K71.12850814
59PIK3CA1.08891357
60PIM11.07544214
61CSNK1G31.03983716
62DYRK1B1.02583782
63BRD40.99054061
64LCK0.98888231
65PRKD20.97619837
66RPS6KA50.96906642
67NLK0.96604033
68MAP2K30.96470393
69FRK0.94570706
70GRK10.94271975
71EPHA30.93486558
72AURKA0.91257437
73CDK70.88074424
74MELK0.87569736
75STK40.84720006
76DYRK20.84349801
77MAPK120.83421525
78MAP3K110.81312285
79IRAK30.80566679
80FLT30.80539366
81PDGFRB0.79775945
82PTK60.79146018
83SIK10.77996111
84JAK10.77397689
85YES10.75711407
86BUB10.74849356
87MAP2K20.74348465
88TEC0.72281410
89MTOR0.71545789
90TAOK10.70139708
91IKBKE0.69380323
92ALK0.69062011
93MAPK110.68331804
94CHUK0.66764458
95MAPKAPK30.66437249
96MARK30.65828420
97MAP3K130.65554521
98MAPK150.64766621
99IKBKB0.64310300
100CDK60.63868028
101CLK10.60439356
102CDC70.60066359
103CHEK10.58579910
104CSNK1G20.57570518
105LMTK20.55008767
106CAMK40.54861069
107TBK10.54158324
108WNK40.54056704
109CSNK1G10.52307826
110MAPK40.51008672
111TLK10.50544199
112MAP3K140.50176338
113EIF2AK30.49814554
114PRKCI0.48789540
115MAP2K60.48331027
116CSNK1A1L0.48170888
117LYN0.47707608
118ABL20.46949406
119RPS6KA60.46596179
120MAP3K60.46580003
121BRSK10.46135691
122TGFBR10.45855632
123CDK20.45351955
124ATR0.45237119
125PRKCQ0.45119172
126JAK20.44583510
127PRKD10.43846148
128MAP3K80.43633620
129TTK0.43090989
130PLK10.42624797
131IRAK10.40602648
132MOS0.40386200
133CHEK20.38754381
134MAP3K40.38718599
135PDGFRA0.37672829
136CSNK2A10.37469305
137PLK40.37421787
138KDR0.37202733
139WNK30.35218569
140GRK50.35129483
141BRSK20.34790593
142WNK10.34778669
143TNK20.34678644
144MAPKAPK20.34664774
145SIK30.34279120
146INSR0.33263331
147ADRBK10.31661430
148MAPK30.31020565
149KIT0.30884854
150CDK30.29969276
151TRIM280.29678749
152RPS6KL10.29359611
153RPS6KC10.29359611
154EIF2AK20.29133415
155AURKB0.28466644
156EPHB10.27785911
157PAK10.27136577

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.62111744
2RNA polymerase_Homo sapiens_hsa030202.83662011
3T cell receptor signaling pathway_Homo sapiens_hsa046602.81075870
4B cell receptor signaling pathway_Homo sapiens_hsa046622.66436390
5Non-homologous end-joining_Homo sapiens_hsa034502.33879452
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.29194548
7Oxidative phosphorylation_Homo sapiens_hsa001902.15169053
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.14544439
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07877106
10Acute myeloid leukemia_Homo sapiens_hsa052211.99609626
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.92039297
12Pyrimidine metabolism_Homo sapiens_hsa002401.79887449
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.79693029
14Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79633011
15Parkinsons disease_Homo sapiens_hsa050121.77441553
16Proteasome_Homo sapiens_hsa030501.75927446
17Antigen processing and presentation_Homo sapiens_hsa046121.73804496
18Chronic myeloid leukemia_Homo sapiens_hsa052201.72999067
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71774851
20Hematopoietic cell lineage_Homo sapiens_hsa046401.63479118
21Graft-versus-host disease_Homo sapiens_hsa053321.60581049
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55537818
23Spliceosome_Homo sapiens_hsa030401.54524716
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54373084
25Allograft rejection_Homo sapiens_hsa053301.53519488
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.52715203
27Measles_Homo sapiens_hsa051621.50528166
28Herpes simplex infection_Homo sapiens_hsa051681.49563352
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47627976
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46831384
31Base excision repair_Homo sapiens_hsa034101.45572919
32Notch signaling pathway_Homo sapiens_hsa043301.43796433
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42832709
34mRNA surveillance pathway_Homo sapiens_hsa030151.42512278
35Ribosome_Homo sapiens_hsa030101.41672529
36HTLV-I infection_Homo sapiens_hsa051661.38613009
37Non-small cell lung cancer_Homo sapiens_hsa052231.36915641
38Steroid biosynthesis_Homo sapiens_hsa001001.36901909
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35612721
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34735179
41Osteoclast differentiation_Homo sapiens_hsa043801.32551365
42Autoimmune thyroid disease_Homo sapiens_hsa053201.30108224
43Huntingtons disease_Homo sapiens_hsa050161.30034079
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29491990
45Cell cycle_Homo sapiens_hsa041101.29374477
46Colorectal cancer_Homo sapiens_hsa052101.29339652
47Regulation of autophagy_Homo sapiens_hsa041401.29295005
48DNA replication_Homo sapiens_hsa030301.23806902
49mTOR signaling pathway_Homo sapiens_hsa041501.22993430
50Nucleotide excision repair_Homo sapiens_hsa034201.22340035
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.21353652
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.21319721
53Asthma_Homo sapiens_hsa053101.20643000
54Pancreatic cancer_Homo sapiens_hsa052121.19713256
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19684332
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16848263
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16408190
58Lysine degradation_Homo sapiens_hsa003101.15806096
59Mismatch repair_Homo sapiens_hsa034301.15647935
60Dorso-ventral axis formation_Homo sapiens_hsa043201.15208872
61MicroRNAs in cancer_Homo sapiens_hsa052061.13781398
62Leishmaniasis_Homo sapiens_hsa051401.10426479
63Selenocompound metabolism_Homo sapiens_hsa004501.10366690
64Other glycan degradation_Homo sapiens_hsa005111.09630628
65Glycosaminoglycan degradation_Homo sapiens_hsa005311.09618148
66Endometrial cancer_Homo sapiens_hsa052131.08742117
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07768931
68Hepatitis B_Homo sapiens_hsa051611.06705672
69Protein export_Homo sapiens_hsa030601.06575904
70Sulfur relay system_Homo sapiens_hsa041221.06411769
71Rheumatoid arthritis_Homo sapiens_hsa053231.06322862
72RNA transport_Homo sapiens_hsa030131.06275394
73Viral carcinogenesis_Homo sapiens_hsa052031.06205346
74Small cell lung cancer_Homo sapiens_hsa052221.05810321
75Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00841994
76Butanoate metabolism_Homo sapiens_hsa006500.99864110
77One carbon pool by folate_Homo sapiens_hsa006700.99831462
78Epstein-Barr virus infection_Homo sapiens_hsa051690.99494588
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.99142143
80FoxO signaling pathway_Homo sapiens_hsa040680.97606224
81Toxoplasmosis_Homo sapiens_hsa051450.97553860
82Purine metabolism_Homo sapiens_hsa002300.95080175
83Basal cell carcinoma_Homo sapiens_hsa052170.94856401
84Fanconi anemia pathway_Homo sapiens_hsa034600.94419411
85Thyroid cancer_Homo sapiens_hsa052160.94155413
86Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.93866193
87RNA degradation_Homo sapiens_hsa030180.92394637
88Chemokine signaling pathway_Homo sapiens_hsa040620.91953133
89VEGF signaling pathway_Homo sapiens_hsa043700.91880951
90Apoptosis_Homo sapiens_hsa042100.91571090
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.89162334
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.86930893
93p53 signaling pathway_Homo sapiens_hsa041150.86925178
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86279575
95Phototransduction_Homo sapiens_hsa047440.85549292
96Shigellosis_Homo sapiens_hsa051310.85504846
97Homologous recombination_Homo sapiens_hsa034400.83277418
98N-Glycan biosynthesis_Homo sapiens_hsa005100.83102139
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82397357
100Prolactin signaling pathway_Homo sapiens_hsa049170.82066276
101Prostate cancer_Homo sapiens_hsa052150.81459562
102Type I diabetes mellitus_Homo sapiens_hsa049400.80931801
103Glutathione metabolism_Homo sapiens_hsa004800.79845562
104Legionellosis_Homo sapiens_hsa051340.79707825
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79471699
106Platelet activation_Homo sapiens_hsa046110.79232435
107Influenza A_Homo sapiens_hsa051640.78683022
108Viral myocarditis_Homo sapiens_hsa054160.77794603
109Alzheimers disease_Homo sapiens_hsa050100.76445361
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76346059
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75655359
112Pathways in cancer_Homo sapiens_hsa052000.74512283
113Choline metabolism in cancer_Homo sapiens_hsa052310.73826351
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73669395
115SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73221899
116Proteoglycans in cancer_Homo sapiens_hsa052050.72315986
117Fatty acid elongation_Homo sapiens_hsa000620.71203166
118Insulin resistance_Homo sapiens_hsa049310.69203963
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67292999
120Adherens junction_Homo sapiens_hsa045200.67161185
121Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65698169
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64866126
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64179886
124Systemic lupus erythematosus_Homo sapiens_hsa053220.63932385
125Peroxisome_Homo sapiens_hsa041460.63011419
126Metabolic pathways_Homo sapiens_hsa011000.62953861
127Renal cell carcinoma_Homo sapiens_hsa052110.61392389
128Hepatitis C_Homo sapiens_hsa051600.60286101
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59206731
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.58138449
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56426978
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.55381037
133Inositol phosphate metabolism_Homo sapiens_hsa005620.55152180
134TNF signaling pathway_Homo sapiens_hsa046680.55137435
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53687946
136ErbB signaling pathway_Homo sapiens_hsa040120.52294580
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49228270
138Glioma_Homo sapiens_hsa052140.48615971
139Wnt signaling pathway_Homo sapiens_hsa043100.48566420
140Basal transcription factors_Homo sapiens_hsa030220.48388289
141MAPK signaling pathway_Homo sapiens_hsa040100.48045955
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47867878
143Lysosome_Homo sapiens_hsa041420.47407854
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47292668
145Sulfur metabolism_Homo sapiens_hsa009200.47257636
146Toll-like receptor signaling pathway_Homo sapiens_hsa046200.45511871
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44657415
148Insulin signaling pathway_Homo sapiens_hsa049100.44637225
149Malaria_Homo sapiens_hsa051440.44302479
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.43167667
151Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.41272924
152Propanoate metabolism_Homo sapiens_hsa006400.41021621
153Endocytosis_Homo sapiens_hsa041440.40443719
154Linoleic acid metabolism_Homo sapiens_hsa005910.39876858
155Rap1 signaling pathway_Homo sapiens_hsa040150.38072310
156HIF-1 signaling pathway_Homo sapiens_hsa040660.37697336
157Circadian rhythm_Homo sapiens_hsa047100.36415468
158Hippo signaling pathway_Homo sapiens_hsa043900.36258635
159Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34705617

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