FBXL14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of NFAT protein import into nucleus (GO:0051532)4.26995879
2positive regulation of gamma-delta T cell activation (GO:0046645)4.26962918
3DNA unwinding involved in DNA replication (GO:0006268)4.06600106
4regulation of gamma-delta T cell differentiation (GO:0045586)3.90294153
5nuclear pore complex assembly (GO:0051292)3.89697012
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.85225521
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.85225521
8histone H3-K36 demethylation (GO:0070544)3.68757440
9protein localization to kinetochore (GO:0034501)3.67342376
10nuclear pore organization (GO:0006999)3.63843757
11regulation of gamma-delta T cell activation (GO:0046643)3.53360012
12mitotic chromosome condensation (GO:0007076)3.50857603
13positive thymic T cell selection (GO:0045059)3.47417436
14mitotic sister chromatid cohesion (GO:0007064)3.46925371
15RNA stabilization (GO:0043489)3.45389535
16mRNA stabilization (GO:0048255)3.45389535
17positive regulation of histone deacetylation (GO:0031065)3.43697882
18negative regulation of histone methylation (GO:0031061)3.42323388
19negative regulation of cell killing (GO:0031342)3.40224017
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.40224017
21response to laminar fluid shear stress (GO:0034616)3.39122858
22pre-miRNA processing (GO:0031054)3.37340314
23positive regulation by symbiont of host defense response (GO:0052509)3.36014514
24modulation by symbiont of host defense response (GO:0052031)3.36014514
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36014514
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36014514
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.36014514
28modulation by symbiont of host immune response (GO:0052553)3.36014514
29apoptotic process involved in morphogenesis (GO:0060561)3.34981920
30regulation of chromatin binding (GO:0035561)3.33041691
313-UTR-mediated mRNA stabilization (GO:0070935)3.31566163
32mannose metabolic process (GO:0006013)3.27935871
33antigen processing and presentation of endogenous antigen (GO:0019883)3.27931080
34protein localization to chromosome, centromeric region (GO:0071459)3.21373065
35positive T cell selection (GO:0043368)3.19512845
36regulation of histone H3-K9 methylation (GO:0051570)3.17587831
37negative T cell selection (GO:0043383)3.16407720
38heterochromatin organization (GO:0070828)3.16360430
39activation of Rac GTPase activity (GO:0032863)3.13984542
40thymic T cell selection (GO:0045061)3.13125948
41mitotic nuclear envelope disassembly (GO:0007077)3.12365186
42modulation by virus of host process (GO:0019054)3.10672398
43sister chromatid segregation (GO:0000819)3.09703192
44chromatin assembly (GO:0031497)3.09213142
45T cell selection (GO:0045058)3.07185453
46dosage compensation (GO:0007549)3.05197400
47positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.03840721
48viral transcription (GO:0019083)3.01839120
49DNA duplex unwinding (GO:0032508)3.00086160
50folic acid-containing compound biosynthetic process (GO:0009396)2.97702897
51response to muramyl dipeptide (GO:0032495)2.96931932
52DNA geometric change (GO:0032392)2.96871324
53natural killer cell differentiation (GO:0001779)2.94770140
54nuclear envelope disassembly (GO:0051081)2.94261825
55membrane disassembly (GO:0030397)2.94261825
56negative thymic T cell selection (GO:0045060)2.93873666
57antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93698048
58V(D)J recombination (GO:0033151)2.93443545
59protein localization to endosome (GO:0036010)2.92038610
60negative regulation of RNA splicing (GO:0033119)2.90330069
61regulation of ARF protein signal transduction (GO:0032012)2.90082289
62pore complex assembly (GO:0046931)2.89128595
63negative regulation of phagocytosis (GO:0050765)2.88922300
64translational termination (GO:0006415)2.88406959
65mitotic sister chromatid segregation (GO:0000070)2.87884229
66modulation by symbiont of host cellular process (GO:0044068)2.87489013
67negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.85093869
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84796066
69interferon-gamma production (GO:0032609)2.83878609
70response to peptidoglycan (GO:0032494)2.83392092
71negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82591834
72histone lysine demethylation (GO:0070076)2.80978199
73regulation of mRNA stability (GO:0043488)2.79042267
74regulation of sister chromatid cohesion (GO:0007063)2.78564088
75regulation of translational fidelity (GO:0006450)2.77390351
76signal complex assembly (GO:0007172)2.76938322
77activation of JUN kinase activity (GO:0007257)2.76146537
78macrophage activation involved in immune response (GO:0002281)2.75338745
79histone demethylation (GO:0016577)2.72072236
80leukocyte aggregation (GO:0070486)2.71697060
81Peyers patch development (GO:0048541)2.70849752
82mucosal-associated lymphoid tissue development (GO:0048537)2.70849752
83regulation of T-helper 2 cell differentiation (GO:0045628)2.70733209
84hepatocyte apoptotic process (GO:0097284)2.70640293
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.69721451
86spliceosomal tri-snRNP complex assembly (GO:0000244)2.69663386
87peptidyl-lysine dimethylation (GO:0018027)2.69417834
88germinal center formation (GO:0002467)2.67901018
89regulation of RNA export from nucleus (GO:0046831)2.67875889
90regulation of RNA stability (GO:0043487)2.67584908
91protein localization to chromosome (GO:0034502)2.65637817
92trophectodermal cell differentiation (GO:0001829)2.65472433
93regulation of mammary gland epithelial cell proliferation (GO:0033599)2.65058764
94regulation of histone H3-K27 methylation (GO:0061085)2.63644335
95positive regulation of protein deacetylation (GO:0090312)2.63213567
96ribosomal small subunit assembly (GO:0000028)2.63035098
97negative regulation of erythrocyte differentiation (GO:0045647)2.62280136
98cytoplasmic mRNA processing body assembly (GO:0033962)2.62095229
99embryonic process involved in female pregnancy (GO:0060136)2.60905864
100regulation of interleukin-12 biosynthetic process (GO:0045075)2.60730839
101regulation of ARF GTPase activity (GO:0032312)2.59475149
102positive regulation of chromosome segregation (GO:0051984)2.59400980
103NIK/NF-kappaB signaling (GO:0038061)2.56781933
104positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.56104022
105translational elongation (GO:0006414)2.55048278
106regulation of B cell receptor signaling pathway (GO:0050855)2.54094131
107positive regulation of gene expression, epigenetic (GO:0045815)2.52743842
108histone H2A monoubiquitination (GO:0035518)2.52329221
109T cell apoptotic process (GO:0070231)2.52063967
110negative regulation of viral release from host cell (GO:1902187)2.51890484
111negative regulation of toll-like receptor signaling pathway (GO:0034122)2.51424213
112cellular response to interleukin-4 (GO:0071353)2.50352228
113regulation of interferon-beta biosynthetic process (GO:0045357)2.50001444
114adherens junction assembly (GO:0034333)2.49786523
115negative regulation of mRNA metabolic process (GO:1903312)2.49767059
116nuclear envelope organization (GO:0006998)2.49745668
117regulation of translational termination (GO:0006449)2.49097193
118negative regulation of mRNA processing (GO:0050686)2.48938575
119positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.48836578
120corticosteroid receptor signaling pathway (GO:0031958)2.48648203
121nucleosome disassembly (GO:0006337)2.48592389
122protein-DNA complex disassembly (GO:0032986)2.48592389
123negative regulation of myotube differentiation (GO:0010832)2.47907111
124epithelial cell differentiation involved in prostate gland development (GO:0060742)2.47696610
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.46225140
126alternative mRNA splicing, via spliceosome (GO:0000380)2.45439138
127positive regulation of B cell differentiation (GO:0045579)2.44904531
128response to UV-C (GO:0010225)2.44757920
129chromatin assembly or disassembly (GO:0006333)2.43625792
130DNA replication-dependent nucleosome organization (GO:0034723)2.41768742
131DNA replication-dependent nucleosome assembly (GO:0006335)2.41768742
132embryonic eye morphogenesis (GO:0048048)2.41333927
133negative regulation of cell size (GO:0045792)2.40684673
134regulation of type I interferon-mediated signaling pathway (GO:0060338)2.40645761
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.40350190
136regulation of defense response to virus by virus (GO:0050690)2.39864448
137maternal placenta development (GO:0001893)2.39546081
138positive regulation of mitotic sister chromatid separation (GO:1901970)2.39081131
139positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.39081131
140positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.39081131
141protein dealkylation (GO:0008214)2.38960797
142protein demethylation (GO:0006482)2.38960797
143embryonic camera-type eye morphogenesis (GO:0048596)2.38699451
144regulation of protein heterodimerization activity (GO:0043497)2.38590935
145megakaryocyte development (GO:0035855)2.37997125
146ncRNA 3-end processing (GO:0043628)2.37980439
147B cell receptor signaling pathway (GO:0050853)2.37665343
148B cell homeostasis (GO:0001782)2.37616061
149translational initiation (GO:0006413)2.37382443
150DNA conformation change (GO:0071103)2.37359257
151peptidyl-threonine phosphorylation (GO:0018107)2.36365460
152positive regulation of Cdc42 GTPase activity (GO:0043089)2.36233022
153response to interleukin-15 (GO:0070672)2.36158807
154cell-substrate adherens junction assembly (GO:0007045)2.35783992
155focal adhesion assembly (GO:0048041)2.35783992
156intracellular estrogen receptor signaling pathway (GO:0030520)2.35427945
157histone H3-K9 demethylation (GO:0033169)2.35278451
158cytoskeletal anchoring at plasma membrane (GO:0007016)2.34526474
159NLS-bearing protein import into nucleus (GO:0006607)2.34369744
160glucocorticoid receptor signaling pathway (GO:0042921)2.34267661
161positive regulation of Rap GTPase activity (GO:0032854)2.33979328
162positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.32690568
163ribosomal small subunit biogenesis (GO:0042274)2.31646173
164regulation of B cell differentiation (GO:0045577)2.31619228
165tolerance induction (GO:0002507)2.31492343
166lymphocyte apoptotic process (GO:0070227)2.31364011
167DNA strand elongation involved in DNA replication (GO:0006271)2.31037036
168histone H4 deacetylation (GO:0070933)2.29571481
169negative regulation of glial cell proliferation (GO:0060253)2.29004931
170stress fiber assembly (GO:0043149)2.24395439
171response to interleukin-4 (GO:0070670)2.24381295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.86893793
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.73442983
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.08338849
4MYC_22102868_ChIP-Seq_BL_Human4.00115458
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.09124095
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91401035
7VDR_21846776_ChIP-Seq_THP-1_Human2.80611605
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.69747198
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.68013860
10LXR_22292898_ChIP-Seq_THP-1_Human2.60620104
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49802594
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.39818158
13TCF7_22412390_ChIP-Seq_EML_Mouse2.28820853
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.22670049
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.19083248
16EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12723197
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.09389080
18* RACK7_27058665_Chip-Seq_MCF-7_Human2.07537913
19* UTX_26944678_Chip-Seq_JUKART_Human2.05896751
20* MAF_26560356_Chip-Seq_TH1_Human2.02676741
21KDM2B_26808549_Chip-Seq_K562_Human1.97095156
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95174322
23MYB_26560356_Chip-Seq_TH2_Human1.94225211
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93484157
25* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.89477296
26ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85828554
27* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.82078122
28SCL_19346495_ChIP-Seq_HPC-7_Human1.80257936
29* KDM2B_26808549_Chip-Seq_DND41_Human1.79877906
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77183821
31* MYB_26560356_Chip-Seq_TH1_Human1.75061474
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73387617
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.73361650
34VDR_24763502_ChIP-Seq_THP-1_Human1.69936547
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69345442
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67292514
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65410092
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64777137
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.64404124
40TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64347642
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58400069
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.56448047
43* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55082204
44CIITA_25753668_ChIP-Seq_RAJI_Human1.54065227
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.53970236
46KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53208755
47* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.53062143
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50419449
49* ELK3_25401928_ChIP-Seq_HUVEC_Human1.49576098
50* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49501167
51IRF8_22096565_ChIP-ChIP_GC-B_Human1.49361164
52RUNX_20019798_ChIP-Seq_JUKART_Human1.48450941
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.47470145
54P68_20966046_ChIP-Seq_HELA_Human1.47265098
55* CREB1_26743006_Chip-Seq_LNCaP_Human1.45086337
56SA1_27219007_Chip-Seq_ERYTHROID_Human1.44479397
57* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44324500
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41302892
59SPI1_23547873_ChIP-Seq_NB4_Human1.40942541
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40475531
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38696867
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.38627451
63MAF_26560356_Chip-Seq_TH2_Human1.35196120
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34708892
65SMC4_20622854_ChIP-Seq_HELA_Human1.34465193
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33143878
67* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31660803
68XRN2_22483619_ChIP-Seq_HELA_Human1.31539757
69CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30667795
70SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30524740
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.30356920
72SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30179768
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.29998196
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.29073592
75UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27861706
76GATA1_19941827_ChIP-Seq_MEL_Mouse1.25782610
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24643749
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.24035981
79* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.23687004
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.23632959
81PKCTHETA_26484144_Chip-Seq_BREAST_Human1.23107034
82KDM5A_27292631_Chip-Seq_BREAST_Human1.22699595
83AR_21909140_ChIP-Seq_LNCAP_Human1.22605465
84ESR2_21235772_ChIP-Seq_MCF-7_Human1.22398912
85NCOR1_26117541_ChIP-Seq_K562_Human1.21116960
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19369517
87NELFA_20434984_ChIP-Seq_ESCs_Mouse1.19183008
88KDM2B_26808549_Chip-Seq_JURKAT_Human1.17306137
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17159301
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16774462
91DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16102703
92* ELF1_20517297_ChIP-Seq_JURKAT_Human1.14674297
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14504078
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13405781
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12763820
96* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.12099669
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11957372
98BCOR_27268052_Chip-Seq_Bcells_Human1.10841388
99* IRF8_27001747_Chip-Seq_BMDM_Mouse1.10413910
100SPI1_23127762_ChIP-Seq_K562_Human1.09465086
101* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07221187
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06502165
103* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.06315901
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.03867506
105MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03437396
106PU.1_20513432_ChIP-Seq_Bcells_Mouse1.02827503
107GATA3_27048872_Chip-Seq_THYMUS_Human1.02696756
108DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01272587
109MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01246630
110* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01029222
111FOXP3_21729870_ChIP-Seq_TREG_Human1.00988811
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00944302
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00548082
114* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00544775
115MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.99669573
116ZFP281_27345836_Chip-Seq_ESCs_Mouse0.98875302
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98648619
118* TP53_22127205_ChIP-Seq_IMR90_Human0.98520298
119STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98510687
120MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97864444
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97385092
122BP1_19119308_ChIP-ChIP_Hs578T_Human0.95893940
123* TFEB_21752829_ChIP-Seq_HELA_Human0.95642782
124ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95579787
125MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95566224
126VDR_23849224_ChIP-Seq_CD4+_Human0.95427554
127IRF8_21731497_ChIP-ChIP_J774_Mouse0.95316812
128ATF3_27146783_Chip-Seq_COLON_Human0.94948480
129SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94902233
130BCL6_27268052_Chip-Seq_Bcells_Human0.93701195
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93346725
132CTCF_21964334_Chip-Seq_Bcells_Human0.92994823
133* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92944763
134NANOG_21062744_ChIP-ChIP_HESCs_Human0.92338013
135CHD1_26751641_Chip-Seq_LNCaP_Human0.91620721
136CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90308659
137FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90158655
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.89991922
139ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89259418
140HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89141694
141TP63_17297297_ChIP-ChIP_HaCaT_Human0.88391762
142* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87917194
143P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87913325
144POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.87851345

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.09245921
2MP0010352_gastrointestinal_tract_polyps2.88083613
3MP0002396_abnormal_hematopoietic_system2.73238600
4MP0003303_peritoneal_inflammation2.70824685
5MP0005076_abnormal_cell_differentiation2.68283750
6MP0009278_abnormal_bone_marrow2.59953713
7MP0003763_abnormal_thymus_physiology2.55244548
8MP0003300_gastrointestinal_ulcer2.52767674
9MP0003693_abnormal_embryo_hatching2.40193181
10MP0010094_abnormal_chromosome_stability2.39919762
11MP0004957_abnormal_blastocyst_morpholog2.29125187
12MP0003111_abnormal_nucleus_morphology2.27855618
13MP0003077_abnormal_cell_cycle2.24381577
14MP0004808_abnormal_hematopoietic_stem2.21677766
15MP0000685_abnormal_immune_system2.15390946
16MP0002398_abnormal_bone_marrow2.11768034
17MP0003705_abnormal_hypodermis_morpholog2.06699585
18MP0010307_abnormal_tumor_latency2.06068569
19MP0001800_abnormal_humoral_immune2.04885925
20MP0000703_abnormal_thymus_morphology2.04604234
21MP0008057_abnormal_DNA_replication1.97926545
22MP0000490_abnormal_crypts_of1.91967360
23MP0003172_abnormal_lysosome_physiology1.89665363
24MP0002166_altered_tumor_susceptibility1.89021553
25MP0001545_abnormal_hematopoietic_system1.88338232
26MP0005397_hematopoietic_system_phenotyp1.88338232
27MP0002722_abnormal_immune_system1.76781240
28MP0003436_decreased_susceptibility_to1.75555496
29MP0008260_abnormal_autophagy1.73840202
30MP0005387_immune_system_phenotype1.72002993
31MP0001790_abnormal_immune_system1.72002993
32MP0002452_abnormal_antigen_presenting1.71902695
33MP0001348_abnormal_lacrimal_gland1.71835316
34MP0002420_abnormal_adaptive_immunity1.71260326
35MP0009333_abnormal_splenocyte_physiolog1.71165548
36MP0000689_abnormal_spleen_morphology1.70988766
37MP0001730_embryonic_growth_arrest1.69670956
38MP0001819_abnormal_immune_cell1.69373942
39MP0000350_abnormal_cell_proliferation1.69167394
40MP0000716_abnormal_immune_system1.66430743
41MP0005671_abnormal_response_to1.63767783
42MP0002405_respiratory_system_inflammati1.61851106
43MP0001835_abnormal_antigen_presentation1.60873422
44MP0004381_abnormal_hair_follicle1.60442425
45MP0002006_tumorigenesis1.57225621
46MP0002723_abnormal_immune_serum1.56743836
47MP0005058_abnormal_lysosome_morphology1.54524493
48MP0005666_abnormal_adipose_tissue1.54231026
49MP0005409_darkened_coat_color1.52154742
50MP0002429_abnormal_blood_cell1.49232289
51MP0005000_abnormal_immune_tolerance1.48788983
52MP0010155_abnormal_intestine_physiology1.47386380
53MP0004947_skin_inflammation1.43351747
54MP0002249_abnormal_larynx_morphology1.42727581
55MP0004858_abnormal_nervous_system1.40712197
56MP0002019_abnormal_tumor_incidence1.40608090
57MP0001849_ear_inflammation1.35244471
58MP0002086_abnormal_extraembryonic_tissu1.34908066
59MP0004185_abnormal_adipocyte_glucose1.34196610
60MP0003566_abnormal_cell_adhesion1.33098920
61MP0005380_embryogenesis_phenotype1.31743497
62MP0001672_abnormal_embryogenesis/_devel1.31743497
63MP0008007_abnormal_cellular_replicative1.30532768
64MP0000858_altered_metastatic_potential1.28884506
65MP0003984_embryonic_growth_retardation1.28763024
66MP0005025_abnormal_response_to1.28251891
67MP0002088_abnormal_embryonic_growth/wei1.27757997
68MP0000537_abnormal_urethra_morphology1.25326302
69MP0004197_abnormal_fetal_growth/weight/1.24537755
70MP0005375_adipose_tissue_phenotype1.24240346
71MP0003866_abnormal_defecation1.23531229
72MP0006054_spinal_hemorrhage1.23399101
73MP0002877_abnormal_melanocyte_morpholog1.23169800
74MP0001697_abnormal_embryo_size1.23162880
75MP0001873_stomach_inflammation1.22467087
76MP0010234_abnormal_vibrissa_follicle1.21640780
77MP0000678_abnormal_parathyroid_gland1.20912420
78MP0005464_abnormal_platelet_physiology1.20516943
79MP0000465_gastrointestinal_hemorrhage1.18789974
80MP0003448_altered_tumor_morphology1.15435481
81MP0002084_abnormal_developmental_patter1.14947964
82MP0002998_abnormal_bone_remodeling1.13970193
83MP0002080_prenatal_lethality1.11523080
84MP0002085_abnormal_embryonic_tissue1.11119929
85MP0009785_altered_susceptibility_to1.09002139
86MP0000733_abnormal_muscle_development1.08549581
87MP0005023_abnormal_wound_healing1.06304255
88MP0000313_abnormal_cell_death1.05634084
89MP0001346_abnormal_lacrimal_gland1.03911495
90MP0005623_abnormal_meninges_morphology1.02672759
91MP0002419_abnormal_innate_immunity1.02432840
92MP0000003_abnormal_adipose_tissue1.01361588
93MP0004233_abnormal_muscle_weight1.00625380
94MP0003191_abnormal_cellular_cholesterol0.99797072
95MP0003123_paternal_imprinting0.99399568
96MP0001845_abnormal_inflammatory_respons0.98346083
97MP0008961_abnormal_basal_metabolism0.97744337
98MP0008058_abnormal_DNA_repair0.94791568
99MP0002089_abnormal_postnatal_growth/wei0.91035645
100MP0000477_abnormal_intestine_morphology0.90983734
101MP0001853_heart_inflammation0.90955821
102MP0006082_CNS_inflammation0.89838187
103MP0009053_abnormal_anal_canal0.89512231
104MP0004510_myositis0.88305901
105MP0009672_abnormal_birth_weight0.88053814
106MP0002925_abnormal_cardiovascular_devel0.87212051
107MP0005310_abnormal_salivary_gland0.86456645
108MP0001915_intracranial_hemorrhage0.84116200
109MP0000566_synostosis0.83612888
110MP0003828_pulmonary_edema0.83594858
111MP0002009_preneoplasia0.83057957
112MP0005670_abnormal_white_adipose0.80848140
113MP0001533_abnormal_skeleton_physiology0.80749618
114MP0004130_abnormal_muscle_cell0.80338795
115MP0003329_amyloid_beta_deposits0.79432840
116MP0003453_abnormal_keratinocyte_physiol0.78548250
117MP0003567_abnormal_fetal_cardiomyocyte0.78526703
118MP0002796_impaired_skin_barrier0.78275418
119MP0003091_abnormal_cell_migration0.77442490
120MP0009115_abnormal_fat_cell0.76840614
121MP0000681_abnormal_thyroid_gland0.76576898
122MP0000015_abnormal_ear_pigmentation0.75731386
123MP0002098_abnormal_vibrissa_morphology0.75506190
124MP0003045_fibrosis0.73579851
125MP0009840_abnormal_foam_cell0.73030064
126MP0003890_abnormal_embryonic-extraembry0.71864705
127MP0009703_decreased_birth_body0.70852362
128MP0002933_joint_inflammation0.70201253
129MP0008770_decreased_survivor_rate0.70176874
130MP0001851_eye_inflammation0.69281324
131MP0005621_abnormal_cell_physiology0.68276614
132MP0004264_abnormal_extraembryonic_tissu0.66129558

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.07393881
2T lymphocytopenia (HP:0005403)3.65111959
3Broad face (HP:0000283)3.45894597
4Abnormality of the fingertips (HP:0001211)3.40376682
5Abnormality of T cell number (HP:0011839)3.39498336
6Recurrent viral infections (HP:0004429)3.27954742
7Recurrent fungal infections (HP:0002841)3.02364378
8Flat acetabular roof (HP:0003180)2.88714509
9Cellulitis (HP:0100658)2.81551466
10IgM deficiency (HP:0002850)2.80621190
11Panhypogammaglobulinemia (HP:0003139)2.79437688
12Increased density of long bones (HP:0006392)2.78418093
13Abnormality of the distal phalanx of the thumb (HP:0009617)2.77360433
14Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.71725803
15Abnormality of T cells (HP:0002843)2.71649179
16Basal cell carcinoma (HP:0002671)2.64711567
17B lymphocytopenia (HP:0010976)2.63378021
18Abnormality of B cell number (HP:0010975)2.63378021
19Nasal polyposis (HP:0100582)2.62136723
20Verrucae (HP:0200043)2.61467180
21Papilloma (HP:0012740)2.61467180
22Combined immunodeficiency (HP:0005387)2.59577055
23Chronic otitis media (HP:0000389)2.59310887
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.54128127
25Thyroiditis (HP:0100646)2.50088566
26Reticulocytopenia (HP:0001896)2.45389585
27Hyperacusis (HP:0010780)2.44260752
28Volvulus (HP:0002580)2.42055134
29Eczematoid dermatitis (HP:0000976)2.40488649
30Recurrent bronchitis (HP:0002837)2.38452253
31Cerebral aneurysm (HP:0004944)2.37636597
32Thrombocytosis (HP:0001894)2.29835774
33Thin bony cortex (HP:0002753)2.29536622
34Short 4th metacarpal (HP:0010044)2.27125400
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27125400
36Gastrointestinal inflammation (HP:0004386)2.26989402
37Abnormality of the phalanges of the hallux (HP:0010057)2.26852931
38Slow saccadic eye movements (HP:0000514)2.26851578
39Ependymoma (HP:0002888)2.25723870
40Abnormality of the nasal mucosa (HP:0000433)2.25099174
41Dysmetric saccades (HP:0000641)2.24870204
42Syringomyelia (HP:0003396)2.24311198
43Spinal cord lesions (HP:0100561)2.24311198
44Severe combined immunodeficiency (HP:0004430)2.23996169
45Disproportionate tall stature (HP:0001519)2.23272353
46Increased nuchal translucency (HP:0010880)2.21020048
47Deep palmar crease (HP:0006191)2.18767360
48Deviation of the thumb (HP:0009603)2.18752171
49Distal lower limb amyotrophy (HP:0008944)2.17001647
50Ulnar bowing (HP:0003031)2.14674869
51Pustule (HP:0200039)2.14172928
52Meningitis (HP:0001287)2.12741435
53Inflammation of the large intestine (HP:0002037)2.12561930
54Proximal placement of thumb (HP:0009623)2.11673104
55Spontaneous hematomas (HP:0007420)2.10199515
56Myositis (HP:0100614)2.08195150
57Prominent nose (HP:0000448)2.07724385
58Hematochezia (HP:0002573)2.07617543
59Abnormal platelet volume (HP:0011876)2.05878476
60Gingivitis (HP:0000230)2.04714128
61Bicuspid aortic valve (HP:0001647)2.04456280
62Easy fatigability (HP:0003388)2.03625327
63Long eyelashes (HP:0000527)2.02976706
64Hemorrhage of the eye (HP:0011885)2.00892047
65Long palpebral fissure (HP:0000637)2.00273115
66Recurrent abscess formation (HP:0002722)1.99570001
67Germ cell neoplasia (HP:0100728)1.99270942
68Subacute progressive viral hepatitis (HP:0006572)1.99239590
69Malignant gastrointestinal tract tumors (HP:0006749)1.98394639
70Gastrointestinal carcinoma (HP:0002672)1.98394639
71Autoimmune thrombocytopenia (HP:0001973)1.97415893
72Recurrent cutaneous fungal infections (HP:0011370)1.97123786
73Chronic mucocutaneous candidiasis (HP:0002728)1.97123786
74Rectal prolapse (HP:0002035)1.95325341
75Broad distal phalanx of finger (HP:0009836)1.95260118
76Bowel incontinence (HP:0002607)1.95107264
77Increased IgE level (HP:0003212)1.95067470
78High pitched voice (HP:0001620)1.94618697
79Eosinophilia (HP:0001880)1.94521229
80Abnormality of oral frenula (HP:0000190)1.94144454
81Broad palm (HP:0001169)1.93858028
82Abnormality of the distal phalanges of the toes (HP:0010182)1.93183776
83Stridor (HP:0010307)1.92797435
84Abnormality of T cell physiology (HP:0011840)1.90996563
85Abnormality of macrophages (HP:0004311)1.90849780
86Segmental peripheral demyelination/remyelination (HP:0003481)1.90062945
87Annular pancreas (HP:0001734)1.89257374
88Abnormality of the columella (HP:0009929)1.88909104
89Myelodysplasia (HP:0002863)1.87315196
90Premature skin wrinkling (HP:0100678)1.86291851
91Abnormality of the thoracic spine (HP:0100711)1.85834590
92Dislocated radial head (HP:0003083)1.85195800
93Urethral obstruction (HP:0000796)1.84782653
94Interstitial pulmonary disease (HP:0006530)1.83632799
95Colitis (HP:0002583)1.83099652
96Abnormal large intestine physiology (HP:0012700)1.82296461
97Viral hepatitis (HP:0006562)1.81959204
98Macroorchidism (HP:0000053)1.80445394
99Abnormality of cells of the lymphoid lineage (HP:0012140)1.78772917
100Rhabdomyosarcoma (HP:0002859)1.78489181
101Poikiloderma (HP:0001029)1.77210163
102Chest pain (HP:0100749)1.75885318
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.75870258
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75837168
105Cutis marmorata (HP:0000965)1.75781025
106Heterotopia (HP:0002282)1.74442359
107Cafe-au-lait spot (HP:0000957)1.74410989
108Ankyloglossia (HP:0010296)1.74309902
109Flattened epiphyses (HP:0003071)1.74065225
110Upper limb amyotrophy (HP:0009129)1.73821634
111Distal upper limb amyotrophy (HP:0007149)1.73821634
112Lymphoma (HP:0002665)1.73301759
113Skin tags (HP:0010609)1.73147460
114Abnormal vertebral ossification (HP:0100569)1.72679932
115Cutaneous melanoma (HP:0012056)1.72663386
116Increased mean platelet volume (HP:0011877)1.72104484
117Genu recurvatum (HP:0002816)1.72009976
118Fatigue (HP:0012378)1.71779105
119Abnormality of the radial head (HP:0003995)1.71270217
120Medulloblastoma (HP:0002885)1.70898910
121Acute myeloid leukemia (HP:0004808)1.70627211
122Lower limb asymmetry (HP:0100559)1.70570282
123Lymphopenia (HP:0001888)1.70244490
124Chromsome breakage (HP:0040012)1.70229091
125Shallow orbits (HP:0000586)1.70065426
126Neoplasm of striated muscle (HP:0009728)1.69611493
127Obstructive lung disease (HP:0006536)1.69548054
128Chronic obstructive pulmonary disease (HP:0006510)1.69548054
129Leukocytosis (HP:0001974)1.69132746
130Sparse lateral eyebrow (HP:0005338)1.68918671
131Astrocytoma (HP:0009592)1.68455213
132Abnormality of the astrocytes (HP:0100707)1.68455213
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.68383852
134Thoracic kyphosis (HP:0002942)1.67651435
135Persistence of primary teeth (HP:0006335)1.67415983
136Elevated erythrocyte sedimentation rate (HP:0003565)1.66987138
137Hypercortisolism (HP:0001578)1.65523337
138Ectopic kidney (HP:0000086)1.65024188
139Mediastinal lymphadenopathy (HP:0100721)1.65007541
140Growth hormone excess (HP:0000845)1.64860660
141Ankle clonus (HP:0011448)1.63861410
142Granulocytopenia (HP:0001913)1.63666178
143Colon cancer (HP:0003003)1.62928921
144Neuronal loss in central nervous system (HP:0002529)1.62537328
145Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.62118426
146Short 1st metacarpal (HP:0010034)1.62118426
147Recurrent bacterial skin infections (HP:0005406)1.61309571
148Abnormality of the aortic arch (HP:0012303)1.61137559
149Gastrointestinal infarctions (HP:0005244)1.61128418
150Sandal gap (HP:0001852)1.61108575
151IgA deficiency (HP:0002720)1.61010438
152Distal lower limb muscle weakness (HP:0009053)1.59570619
153Deformed sella turcica (HP:0002681)1.59149443
154Abnormal ossification of hand bones (HP:0005921)1.59126467
155Hyperparathyroidism (HP:0000843)1.58657316
156Onion bulb formation (HP:0003383)1.58111360
157Abnormality of the intervertebral disk (HP:0005108)1.57736685
158Narrow palate (HP:0000189)1.56937463
159Achilles tendon contracture (HP:0001771)1.55852523
160High anterior hairline (HP:0009890)1.55147995
161Flared metaphyses (HP:0003015)1.54599805
162Agammaglobulinemia (HP:0004432)1.53950871
163Gastrointestinal stroma tumor (HP:0100723)1.52816202
164Turricephaly (HP:0000262)1.52377282
165Pointed chin (HP:0000307)1.51777813
166Severe short stature (HP:0003510)1.50924109
167Truncal obesity (HP:0001956)1.50858443
168Aneurysm (HP:0002617)1.50381909
169Supranuclear gaze palsy (HP:0000605)1.50184740
170Trigonocephaly (HP:0000243)1.49858654

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.38675550
2MAP3K103.94728712
3CDK123.80847210
4PRPF4B3.75014620
5MAP4K13.57764086
6SMG13.35058789
7PKN23.19190040
8STK102.76883711
9TRIB32.76395212
10CDC72.33168056
11GRK62.30480877
12NEK22.22785160
13IRAK32.20746245
14RIPK41.97453053
15LRRK21.80556739
16JAK31.69586336
17CAMK1G1.64256165
18RPS6KB21.60283107
19MARK21.57136127
20RPS6KA41.53792561
21CDK41.50220366
22ERN11.45791928
23IRAK41.40596824
24ALK1.40589406
25PTK61.37751100
26PRKD31.33267097
27CDK61.32786175
28ZAP701.32544300
29ITK1.30301309
30TXK1.27810670
31PIM11.25651017
32TYK21.24986350
33IRAK21.22500532
34MAP3K81.21578600
35BTK1.21055237
36FLT31.20623023
37TGFBR21.20061342
38CLK11.13773251
39CSK1.11640370
40MAP3K131.10678624
41STK41.07320129
42MAP3K111.07149009
43FGFR31.07104234
44CDK71.07066369
45KSR21.05701870
46MAP3K31.04105421
47SCYL20.99632577
48CSF1R0.98506244
49SIK20.98273642
50CAMKK10.97236847
51PASK0.96570820
52TTN0.96058323
53HCK0.94934029
54PDPK10.94855593
55MAP2K30.93546838
56SIK30.93037445
57PAK40.92454358
58EPHA20.91560329
59BRD40.91369477
60MAP3K10.90615544
61PDK10.90262548
62CDK90.88910769
63STK30.87606862
64ICK0.86684330
65HIPK20.85650847
66FES0.83227514
67TAOK10.82378321
68LCK0.81989697
69SGK30.81762180
70BMX0.79727131
71MELK0.76868773
72LATS10.76395916
73TAOK20.76082767
74MTOR0.75937861
75ATR0.74827450
76TGFBR10.73167746
77CHEK10.73018111
78PDGFRA0.72194879
79TTK0.71553955
80SYK0.70833864
81CAMK40.70365000
82RPS6KA20.70223246
83MARK30.69271423
84FGFR40.68567953
85MAPK120.67442496
86AURKB0.67256608
87JAK20.63830945
88BLK0.63152289
89CDC42BPA0.62958972
90WEE10.62951558
91EPHB10.61970979
92MAP3K140.61871596
93CHUK0.61693424
94DYRK30.61608235
95CAMK1D0.61583349
96TNK20.60206598
97TSSK60.60082011
98TLK10.59774613
99LMTK20.58631077
100RIPK10.58159387
101TEC0.57623507
102RPS6KA60.57586485
103DMPK0.56245081
104RPS6KC10.56028711
105RPS6KL10.56028711
106CDK20.55786419
107TYRO30.54954627
108PDGFRB0.54699034
109TRPM70.54363600
110STK380.54152886
111ATM0.53577389
112IKBKE0.53466215
113JAK10.52718835
114MAP2K20.52203152
115CHEK20.51295373
116NLK0.51227380
117TBK10.50731785
118NME20.50342451
119MAPK110.48049293
120BRAF0.47624927
121PAK20.46837652
122IRAK10.46156594
123MAPK70.46013466
124DYRK1B0.45950684
125YES10.45181592
126NEK60.44812727
127MAPKAPK20.43826542
128FGR0.43814374
129UHMK10.43710378
130SIK10.43243828
131RPS6KA10.42707088
132PRKCH0.42426651
133RET0.42085539
134PRKD20.41534946
135PLK10.41163970
136ARAF0.38995424
137LYN0.38337816
138MAP3K70.38218920
139IKBKB0.37452832
140MAPK80.32439132

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.55886681
2DNA replication_Homo sapiens_hsa030302.32828338
3Chronic myeloid leukemia_Homo sapiens_hsa052201.94340734
4B cell receptor signaling pathway_Homo sapiens_hsa046621.86700697
5Antigen processing and presentation_Homo sapiens_hsa046121.78118768
6Mismatch repair_Homo sapiens_hsa034301.76743830
7Cell cycle_Homo sapiens_hsa041101.71168439
8T cell receptor signaling pathway_Homo sapiens_hsa046601.70369423
9Spliceosome_Homo sapiens_hsa030401.66944107
10Base excision repair_Homo sapiens_hsa034101.58546892
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.56608353
12RNA transport_Homo sapiens_hsa030131.56559265
13Acute myeloid leukemia_Homo sapiens_hsa052211.55411675
14Leishmaniasis_Homo sapiens_hsa051401.54524190
15Viral carcinogenesis_Homo sapiens_hsa052031.50269190
16mRNA surveillance pathway_Homo sapiens_hsa030151.47757292
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.47704082
18Osteoclast differentiation_Homo sapiens_hsa043801.46373220
19Measles_Homo sapiens_hsa051621.42624465
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.40958240
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40817972
22Herpes simplex infection_Homo sapiens_hsa051681.40431326
23Phosphatidylinositol signaling system_Homo sapiens_hsa040701.40100024
24Other glycan degradation_Homo sapiens_hsa005111.39085738
25Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38852027
26Colorectal cancer_Homo sapiens_hsa052101.38745677
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38288159
28Non-homologous end-joining_Homo sapiens_hsa034501.37877513
29HTLV-I infection_Homo sapiens_hsa051661.37721655
30ErbB signaling pathway_Homo sapiens_hsa040121.37624657
31Pancreatic cancer_Homo sapiens_hsa052121.36523135
32Small cell lung cancer_Homo sapiens_hsa052221.33518348
33MicroRNAs in cancer_Homo sapiens_hsa052061.33266589
34Non-small cell lung cancer_Homo sapiens_hsa052231.32610651
35Hepatitis B_Homo sapiens_hsa051611.31894845
36mTOR signaling pathway_Homo sapiens_hsa041501.31641801
37One carbon pool by folate_Homo sapiens_hsa006701.31141878
38Leukocyte transendothelial migration_Homo sapiens_hsa046701.30495318
39Ribosome_Homo sapiens_hsa030101.30316178
40Systemic lupus erythematosus_Homo sapiens_hsa053221.26251045
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23295739
42Hematopoietic cell lineage_Homo sapiens_hsa046401.23134003
43p53 signaling pathway_Homo sapiens_hsa041151.20637597
44Notch signaling pathway_Homo sapiens_hsa043301.18086675
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.17943477
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.17280800
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16740766
48Toxoplasmosis_Homo sapiens_hsa051451.16638763
49Viral myocarditis_Homo sapiens_hsa054161.15856788
50Shigellosis_Homo sapiens_hsa051311.12484453
51Choline metabolism in cancer_Homo sapiens_hsa052311.11910670
52Thyroid cancer_Homo sapiens_hsa052161.11013503
53Apoptosis_Homo sapiens_hsa042101.10842601
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10663576
55Jak-STAT signaling pathway_Homo sapiens_hsa046301.07189495
56Phospholipase D signaling pathway_Homo sapiens_hsa040721.05759965
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05261272
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.04347747
59Insulin signaling pathway_Homo sapiens_hsa049101.03200521
60Adherens junction_Homo sapiens_hsa045201.02782905
61Neurotrophin signaling pathway_Homo sapiens_hsa047221.01111391
62Sphingolipid signaling pathway_Homo sapiens_hsa040711.00993328
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.99499360
64Endometrial cancer_Homo sapiens_hsa052130.99116504
65Estrogen signaling pathway_Homo sapiens_hsa049150.98580131
66Chemokine signaling pathway_Homo sapiens_hsa040620.96896427
67Nucleotide excision repair_Homo sapiens_hsa034200.96239518
68Renal cell carcinoma_Homo sapiens_hsa052110.96125808
69Platelet activation_Homo sapiens_hsa046110.95770365
70Epstein-Barr virus infection_Homo sapiens_hsa051690.93651375
71Homologous recombination_Homo sapiens_hsa034400.92932961
72GnRH signaling pathway_Homo sapiens_hsa049120.92909970
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92799584
74VEGF signaling pathway_Homo sapiens_hsa043700.92590459
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92471251
76Proteoglycans in cancer_Homo sapiens_hsa052050.92424540
77Legionellosis_Homo sapiens_hsa051340.92081933
78RNA degradation_Homo sapiens_hsa030180.90488190
79Long-term potentiation_Homo sapiens_hsa047200.88982657
80Prostate cancer_Homo sapiens_hsa052150.88895544
81Prolactin signaling pathway_Homo sapiens_hsa049170.88773092
82Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88623744
83Influenza A_Homo sapiens_hsa051640.88579225
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85362655
85Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84998372
86AMPK signaling pathway_Homo sapiens_hsa041520.84692632
87TNF signaling pathway_Homo sapiens_hsa046680.83450171
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.83099572
89Bladder cancer_Homo sapiens_hsa052190.82856846
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82684544
91Lysine degradation_Homo sapiens_hsa003100.81597257
92FoxO signaling pathway_Homo sapiens_hsa040680.81514805
93Fanconi anemia pathway_Homo sapiens_hsa034600.81273037
94Endocytosis_Homo sapiens_hsa041440.80051814
95Glycosaminoglycan degradation_Homo sapiens_hsa005310.79649149
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79479616
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78654640
98Tuberculosis_Homo sapiens_hsa051520.78283227
99HIF-1 signaling pathway_Homo sapiens_hsa040660.76653082
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75896151
101Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75090266
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.74422789
103Pathways in cancer_Homo sapiens_hsa052000.74405242
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73992359
105Glioma_Homo sapiens_hsa052140.71716003
106Type II diabetes mellitus_Homo sapiens_hsa049300.69602133
107Prion diseases_Homo sapiens_hsa050200.69185060
108Dorso-ventral axis formation_Homo sapiens_hsa043200.68066641
109TGF-beta signaling pathway_Homo sapiens_hsa043500.65859475
110Alcoholism_Homo sapiens_hsa050340.64429722
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64429347
112Focal adhesion_Homo sapiens_hsa045100.63574011
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63444434
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62410121
115Insulin resistance_Homo sapiens_hsa049310.57935167
116Melanogenesis_Homo sapiens_hsa049160.57905214
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56336310
118Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55360360
119Fructose and mannose metabolism_Homo sapiens_hsa000510.54376596
120Basal cell carcinoma_Homo sapiens_hsa052170.53294090
121Salmonella infection_Homo sapiens_hsa051320.53151241
122Hippo signaling pathway_Homo sapiens_hsa043900.53147444
123Rap1 signaling pathway_Homo sapiens_hsa040150.52238108
124Hepatitis C_Homo sapiens_hsa051600.52097923
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51953714
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50932344
127MAPK signaling pathway_Homo sapiens_hsa040100.50468693
128Fatty acid biosynthesis_Homo sapiens_hsa000610.49131243
129Sulfur relay system_Homo sapiens_hsa041220.49012674
130Pertussis_Homo sapiens_hsa051330.48358808
131Inositol phosphate metabolism_Homo sapiens_hsa005620.47614314

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