FBXL15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.10666242
2deoxyribonucleotide catabolic process (GO:0009264)4.60004593
3pyrimidine nucleotide catabolic process (GO:0006244)4.56291708
4purine deoxyribonucleotide catabolic process (GO:0009155)4.46723614
5base-excision repair, AP site formation (GO:0006285)4.44469996
6response to pheromone (GO:0019236)4.27885996
7deoxyribose phosphate catabolic process (GO:0046386)4.26909141
8anterograde synaptic vesicle transport (GO:0048490)4.21647536
9deoxyribose phosphate biosynthetic process (GO:0046385)4.16790707
102-deoxyribonucleotide biosynthetic process (GO:0009265)4.16790707
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.00381876
12negative regulation of B cell apoptotic process (GO:0002903)3.99106324
13neuromuscular process controlling posture (GO:0050884)3.69982709
142-deoxyribonucleotide metabolic process (GO:0009394)3.67663336
15purine deoxyribonucleotide metabolic process (GO:0009151)3.61496029
16positive regulation of prostaglandin secretion (GO:0032308)3.56049190
17NIK/NF-kappaB signaling (GO:0038061)3.55021979
18mature B cell differentiation involved in immune response (GO:0002313)3.51401857
19protein insertion into membrane (GO:0051205)3.45988946
20phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.45862603
21activation of MAPKKK activity (GO:0000185)3.45164249
22nucleotide salvage (GO:0043173)3.44623295
23negative regulation of microtubule polymerization (GO:0031115)3.42734924
24anterograde axon cargo transport (GO:0008089)3.42087947
25synaptic vesicle maturation (GO:0016188)3.40060707
26sequestering of actin monomers (GO:0042989)3.33277300
27deoxyribose phosphate metabolic process (GO:0019692)3.32343027
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.31923213
29negative regulation of myeloid cell apoptotic process (GO:0033033)3.31415867
30protein targeting to mitochondrion (GO:0006626)3.29704504
31immunoglobulin mediated immune response (GO:0016064)3.27050275
32establishment of protein localization to mitochondrion (GO:0072655)3.25899649
33synaptic vesicle exocytosis (GO:0016079)3.25746425
34protein maturation by protein folding (GO:0022417)3.22397573
35GDP-mannose metabolic process (GO:0019673)3.22001045
36neurofilament cytoskeleton organization (GO:0060052)3.20453641
37iron-sulfur cluster assembly (GO:0016226)3.18646409
38metallo-sulfur cluster assembly (GO:0031163)3.18646409
39phosphatidylglycerol biosynthetic process (GO:0006655)3.13854913
40negative regulation of erythrocyte differentiation (GO:0045647)3.13433030
41negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.03366022
42purine-containing compound salvage (GO:0043101)3.02661971
43ribosomal small subunit biogenesis (GO:0042274)3.01995789
44chaperone-mediated protein transport (GO:0072321)2.99527688
45purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.98269314
46heme biosynthetic process (GO:0006783)2.97083368
47regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.96787508
48regulation of B cell apoptotic process (GO:0002902)2.93284876
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90265959
50endosome to pigment granule transport (GO:0043485)2.89134718
51endosome to melanosome transport (GO:0035646)2.89134718
52positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.87430424
53protein complex biogenesis (GO:0070271)2.87085932
54protein localization to mitochondrion (GO:0070585)2.84187246
55regulation of mitochondrial translation (GO:0070129)2.82599050
56ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.82505995
57neuronal action potential propagation (GO:0019227)2.81391001
58NADH metabolic process (GO:0006734)2.80327312
59glutathione biosynthetic process (GO:0006750)2.80077243
60axon cargo transport (GO:0008088)2.79879871
61mitochondrial respiratory chain complex I assembly (GO:0032981)2.78960946
62NADH dehydrogenase complex assembly (GO:0010257)2.78960946
63mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78960946
64melanosome transport (GO:0032402)2.78218515
65pyrimidine nucleobase catabolic process (GO:0006208)2.76673540
66regulation of cellular amino acid metabolic process (GO:0006521)2.75340206
67respiratory system process (GO:0003016)2.75314200
68autophagic vacuole fusion (GO:0000046)2.74502094
69deoxyribonucleotide metabolic process (GO:0009262)2.74441858
70pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74042359
71mitochondrial calcium ion transport (GO:0006851)2.73325994
72proteasome assembly (GO:0043248)2.72615511
73regulation of early endosome to late endosome transport (GO:2000641)2.71806425
74viral transcription (GO:0019083)2.71643722
75negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.71281057
76negative regulation of ligase activity (GO:0051352)2.71281057
77mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.70786752
78GMP metabolic process (GO:0046037)2.69928523
79nucleoside diphosphate biosynthetic process (GO:0009133)2.69575007
80peptidyl-histidine modification (GO:0018202)2.68998684
81deoxyribonucleotide biosynthetic process (GO:0009263)2.68829887
82negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.68463956
83ribonucleoprotein complex disassembly (GO:0032988)2.68242876
84translational elongation (GO:0006414)2.68051516
85regulation of prostaglandin secretion (GO:0032306)2.67620014
86glutamate secretion (GO:0014047)2.67420256
87positive regulation of antigen processing and presentation (GO:0002579)2.67081055
88response to peptidoglycan (GO:0032494)2.66503667
89dopamine receptor signaling pathway (GO:0007212)2.65613065
90respiratory chain complex IV assembly (GO:0008535)2.65504270
91ATP synthesis coupled proton transport (GO:0015986)2.65398615
92energy coupled proton transport, down electrochemical gradient (GO:0015985)2.65398615
93GPI anchor biosynthetic process (GO:0006506)2.65109831
94deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.64388605
95pyrimidine-containing compound salvage (GO:0008655)2.61747189
96pyrimidine nucleoside salvage (GO:0043097)2.61747189
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.61423288
98deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.61408182
99negative regulation of calcium ion transport into cytosol (GO:0010523)2.60052223
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.59373707
101adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.59215817
102mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.59208973
103pigment granule transport (GO:0051904)2.58673692
104nucleobase-containing small molecule interconversion (GO:0015949)2.58339329
105* SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)2.58258459
106mitochondrial respiratory chain complex assembly (GO:0033108)2.57618761
107prostaglandin biosynthetic process (GO:0001516)2.57511268
108prostanoid biosynthetic process (GO:0046457)2.57511268
109positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.56307690
110translational termination (GO:0006415)2.55968836
111heme metabolic process (GO:0042168)2.55772941
112UV protection (GO:0009650)2.55304889
113positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.54640287
114ncRNA 3-end processing (GO:0043628)2.53988312
115cotranslational protein targeting to membrane (GO:0006613)2.53909998
116establishment of melanosome localization (GO:0032401)2.53168181
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52964468
118regulation of antigen processing and presentation (GO:0002577)2.51927605
119negative regulation of type 2 immune response (GO:0002829)2.51784812
120protein targeting to ER (GO:0045047)2.51148059
121guanosine-containing compound biosynthetic process (GO:1901070)2.50237000
122positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.49806527
123negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.49680529
124regulation of cytokine production involved in inflammatory response (GO:1900015)2.49649031
125melanosome localization (GO:0032400)2.49563820
126positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.48921066
127protein localization to endoplasmic reticulum (GO:0070972)2.47603972
128cellular metabolic compound salvage (GO:0043094)2.47159808
129mucosal-associated lymphoid tissue development (GO:0048537)2.47151044
130Peyers patch development (GO:0048541)2.47151044
131Arp2/3 complex-mediated actin nucleation (GO:0034314)2.46870739
132mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.46773636
133ribosomal small subunit assembly (GO:0000028)2.46671682
134synaptic vesicle transport (GO:0048489)2.46567954
135establishment of synaptic vesicle localization (GO:0097480)2.46567954
136mature B cell differentiation (GO:0002335)2.46335535
137regulation of synapse structural plasticity (GO:0051823)2.46052079
138nucleobase catabolic process (GO:0046113)2.45791269
139energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.44473656
140ATP hydrolysis coupled proton transport (GO:0015991)2.44473656
141negative regulation of interleukin-12 production (GO:0032695)2.43213265
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.43145647
143regulation of neuron projection regeneration (GO:0070570)2.42921238
144regulation of axon regeneration (GO:0048679)2.42921238
145negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.42107688
146protein localization to synapse (GO:0035418)2.41749093
147cytochrome complex assembly (GO:0017004)2.40215073
148reactive oxygen species biosynthetic process (GO:1903409)2.40096746
149purine nucleotide salvage (GO:0032261)2.39885803
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39410636
151nonribosomal peptide biosynthetic process (GO:0019184)2.38784393
152mitochondrial RNA metabolic process (GO:0000959)2.38574824
153establishment of protein localization to endoplasmic reticulum (GO:0072599)2.37726186
154regulation of defense response to virus by virus (GO:0050690)2.36738094
155establishment of pigment granule localization (GO:0051905)2.35650410
156GTP biosynthetic process (GO:0006183)2.33874193
157estrogen biosynthetic process (GO:0006703)2.30491347
158lipoxygenase pathway (GO:0019372)2.29760504
159tumor necrosis factor-mediated signaling pathway (GO:0033209)2.29684836
160regulation of chemokine biosynthetic process (GO:0045073)2.29286377
161regulation of mast cell degranulation (GO:0043304)2.28606541
162negative regulation of amino acid transport (GO:0051956)2.28557772
163respiratory electron transport chain (GO:0022904)2.28467893
164response to protozoan (GO:0001562)2.27766070
165establishment of mitochondrion localization (GO:0051654)2.27569293
166positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.27378597
167phagosome maturation (GO:0090382)2.27246439
168positive regulation of icosanoid secretion (GO:0032305)2.26952046
169negative regulation of tumor necrosis factor production (GO:0032720)2.26637354
170electron transport chain (GO:0022900)2.25798728
171mannosylation (GO:0097502)2.23482704
172negative regulation of nitric oxide biosynthetic process (GO:0045019)2.23416519
173regulation of protein kinase A signaling (GO:0010738)2.22330364
174positive regulation of B cell differentiation (GO:0045579)2.22299744
175GPI anchor metabolic process (GO:0006505)2.19691191
176negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.19508006
177B cell mediated immunity (GO:0019724)2.18793052
178positive regulation of TOR signaling (GO:0032008)2.18786365
179interferon-gamma-mediated signaling pathway (GO:0060333)2.17072497
180pentose metabolic process (GO:0019321)2.16896701

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.92274009
2* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.24480701
3NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.00461719
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.83236187
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.68313889
6SRY_22984422_ChIP-ChIP_TESTIS_Rat2.60930294
7* ETS1_20019798_ChIP-Seq_JURKAT_Human2.53457245
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.48665477
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.33114279
10MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.29831810
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.27085475
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.24205775
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22720225
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.21798403
15SIN3A_21632747_ChIP-Seq_MESCs_Mouse2.11089649
16THAP11_20581084_ChIP-Seq_MESCs_Mouse2.08704138
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.05576454
18VDR_21846776_ChIP-Seq_THP-1_Human2.04806226
19XRN2_22483619_ChIP-Seq_HELA_Human2.04535083
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.03634208
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02856232
22* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01643487
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99670529
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97722057
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.96864349
26* TET1_21451524_ChIP-Seq_MESCs_Mouse1.93350287
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.91961443
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.88518588
29ZNF263_19887448_ChIP-Seq_K562_Human1.86815587
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.84895757
31CTCF_18555785_ChIP-Seq_MESCs_Mouse1.83937093
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.83267043
33GABP_19822575_ChIP-Seq_HepG2_Human1.81422215
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79166844
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.77901276
36VDR_24763502_ChIP-Seq_THP-1_Human1.77365152
37LXR_22292898_ChIP-Seq_THP-1_Human1.76819129
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71621864
39MYC_22102868_ChIP-Seq_BL_Human1.66407705
40EZH2_22144423_ChIP-Seq_EOC_Human1.66376081
41DCP1A_22483619_ChIP-Seq_HELA_Human1.65680499
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.65385792
43YY1_22570637_ChIP-Seq_MALME-3M_Human1.62046537
44* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.61634433
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.61481462
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.61122805
47* MAF_26560356_Chip-Seq_TH2_Human1.57604725
48* E2F1_20622854_ChIP-Seq_HELA_Human1.57295632
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56078486
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54911119
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52440678
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52058314
53* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50289646
54CTCF_20526341_ChIP-Seq_ESCs_Human1.46346950
55* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.45360624
56VDR_23849224_ChIP-Seq_CD4+_Human1.45194691
57* UTX_26944678_Chip-Seq_JUKART_Human1.44155028
58* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.44003644
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.43713301
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42823269
61BCL6_27268052_Chip-Seq_Bcells_Human1.41969629
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.40749361
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38073772
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.37876418
65* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36764211
66* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34547087
67REST_18959480_ChIP-ChIP_MESCs_Mouse1.33948063
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32629819
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32100904
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.31766277
71MAF_26560356_Chip-Seq_TH1_Human1.31716185
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30307785
73DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29884505
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.29805588
75IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29456350
76* REST_21632747_ChIP-Seq_MESCs_Mouse1.29017874
77* CTCF_26484167_Chip-Seq_Bcells_Mouse1.28756307
78SMC4_20622854_ChIP-Seq_HELA_Human1.28032570
79CTCF_27219007_Chip-Seq_Bcells_Human1.27974707
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.27712073
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27679004
82KDM2B_26808549_Chip-Seq_DND41_Human1.26904444
83* FOXP1_21924763_ChIP-Seq_HESCs_Human1.26780573
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26274113
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.25992498
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25906113
87CTCF_21964334_Chip-Seq_Bcells_Human1.25868415
88TTF2_22483619_ChIP-Seq_HELA_Human1.25151957
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24941885
90SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24533349
91SA1_27219007_Chip-Seq_Bcells_Human1.23650869
92* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.22948105
93* P300_27268052_Chip-Seq_Bcells_Human1.22906117
94FOXP3_21729870_ChIP-Seq_TREG_Human1.22310394
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21702043
96SPI1_23547873_ChIP-Seq_NB4_Human1.21617861
97P68_20966046_ChIP-Seq_HELA_Human1.21202809
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.20393970
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18769981
100GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18551964
101BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.18387617
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.18251684
103CIITA_25753668_ChIP-Seq_RAJI_Human1.17581018
104* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17086033
105* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17066392
106CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16327176
107RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16030624
108* PHF8_20622854_ChIP-Seq_HELA_Human1.14715716
109* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.13672429
110* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13502402
111* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13329854
112* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12909106
113RUNX1_22412390_ChIP-Seq_EML_Mouse1.12478706
114RARB_24833708_ChIP-Seq_LIVER_Mouse1.12307687
115ERG_21242973_ChIP-ChIP_JURKAT_Human1.12235036
116PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12003196
117SCL_19346495_ChIP-Seq_HPC-7_Human1.12002942
118* BCOR_27268052_Chip-Seq_Bcells_Human1.11675632
119SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11557508
120* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.10445489
121* SA1_27219007_Chip-Seq_ERYTHROID_Human1.09979095
122SPI1_20517297_ChIP-Seq_HL60_Human1.09024970
123STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08952092
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07629903
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06708016
126PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.06489882
127* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06411593
128* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05674568
129GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05279330
130FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05186340
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04904955
132ETS1_21867929_ChIP-Seq_TH2_Mouse1.03809291
133* RACK7_27058665_Chip-Seq_MCF-7_Human1.03164140
134CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02438971
135* ELK3_25401928_ChIP-Seq_HUVEC_Human1.01956840
136PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01732512

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.58145292
2MP0005058_abnormal_lysosome_morphology3.31684272
3MP0001968_abnormal_touch/_nociception3.31515170
4MP0001986_abnormal_taste_sensitivity3.03142798
5MP0002735_abnormal_chemical_nociception2.86397577
6MP0002736_abnormal_nociception_after2.72249466
7MP0003303_peritoneal_inflammation2.62933393
8MP0002909_abnormal_adrenal_gland2.55693124
9MP0009278_abnormal_bone_marrow2.51378460
10MP0008260_abnormal_autophagy2.41892685
11MP0006276_abnormal_autonomic_nervous2.37751146
12MP0005083_abnormal_biliary_tract2.22926917
13MP0001545_abnormal_hematopoietic_system2.17515735
14MP0005397_hematopoietic_system_phenotyp2.17515735
15MP0005451_abnormal_body_composition2.16612161
16MP0003806_abnormal_nucleotide_metabolis2.15095583
17MP0004510_myositis2.14629869
18MP0009840_abnormal_foam_cell2.12284566
19MP0004858_abnormal_nervous_system2.10997445
20MP0002733_abnormal_thermal_nociception2.10393658
21MP0003635_abnormal_synaptic_transmissio2.05890019
22MP0001835_abnormal_antigen_presentation2.03206302
23MP0003656_abnormal_erythrocyte_physiolo2.01366558
24MP0003693_abnormal_embryo_hatching1.88577973
25MP0003879_abnormal_hair_cell1.86972681
26MP0010386_abnormal_urinary_bladder1.84038863
27MP0004142_abnormal_muscle_tone1.82349204
28MP0002063_abnormal_learning/memory/cond1.82084919
29MP0002419_abnormal_innate_immunity1.76016385
30MP0003075_altered_response_to1.74949366
31MP0003724_increased_susceptibility_to1.70461220
32MP0003880_abnormal_central_pattern1.67932905
33MP0001970_abnormal_pain_threshold1.67854976
34MP0003329_amyloid_beta_deposits1.67498582
35MP0004270_analgesia1.64442291
36MP0003122_maternal_imprinting1.63871469
37MP0006036_abnormal_mitochondrial_physio1.63755504
38MP0004811_abnormal_neuron_physiology1.61868463
39MP0002272_abnormal_nervous_system1.61032109
40MP0001800_abnormal_humoral_immune1.59821779
41MP0002064_seizures1.59460777
42MP0002734_abnormal_mechanical_nocicepti1.56250151
43MP0005387_immune_system_phenotype1.55852730
44MP0001790_abnormal_immune_system1.55852730
45MP0009764_decreased_sensitivity_to1.55030422
46MP0002452_abnormal_antigen_presenting1.54575240
47MP0002420_abnormal_adaptive_immunity1.53457407
48MP0003436_decreased_susceptibility_to1.53193599
49MP0001819_abnormal_immune_cell1.52697716
50MP0000465_gastrointestinal_hemorrhage1.51262425
51MP0002184_abnormal_innervation1.50412757
52MP0005084_abnormal_gallbladder_morpholo1.50240082
53MP0003172_abnormal_lysosome_physiology1.49716240
54MP0003787_abnormal_imprinting1.46207670
55MP0005464_abnormal_platelet_physiology1.44286031
56MP0006035_abnormal_mitochondrial_morpho1.42699361
57MP0005646_abnormal_pituitary_gland1.41054753
58MP0002751_abnormal_autonomic_nervous1.39951866
59MP0004043_abnormal_pH_regulation1.38874484
60MP0009745_abnormal_behavioral_response1.35905775
61MP0001905_abnormal_dopamine_level1.33026370
62MP0008961_abnormal_basal_metabolism1.31668680
63MP0005636_abnormal_mineral_homeostasis1.31282395
64MP0003191_abnormal_cellular_cholesterol1.30831337
65MP0002572_abnormal_emotion/affect_behav1.30329546
66MP0005423_abnormal_somatic_nervous1.28564343
67MP0001873_stomach_inflammation1.28231482
68MP0001984_abnormal_olfaction1.26462088
69MP0009333_abnormal_splenocyte_physiolog1.24313325
70MP0001440_abnormal_grooming_behavior1.23288329
71MP0005166_decreased_susceptibility_to1.22940963
72MP0001501_abnormal_sleep_pattern1.21629892
73MP0000716_abnormal_immune_system1.20321576
74MP0006292_abnormal_olfactory_placode1.19206444
75MP0003195_calcinosis1.18533251
76MP0001533_abnormal_skeleton_physiology1.17063688
77MP0006072_abnormal_retinal_apoptosis1.16241037
78MP0002822_catalepsy1.14894288
79MP0001764_abnormal_homeostasis1.14285847
80MP0000343_altered_response_to1.14252444
81MP0000490_abnormal_crypts_of1.13258811
82MP0002067_abnormal_sensory_capabilities1.11659975
83MP0009046_muscle_twitch1.11183112
84MP0002139_abnormal_hepatobiliary_system1.10989698
85MP0004147_increased_porphyrin_level1.08092294
86MP0002557_abnormal_social/conspecific_i1.07595051
87MP0000015_abnormal_ear_pigmentation1.06966553
88MP0000689_abnormal_spleen_morphology1.06957604
89MP0003186_abnormal_redox_activity1.05532974
90MP0004782_abnormal_surfactant_physiolog1.03516588
91MP0003866_abnormal_defecation1.03428614
92MP0000955_abnormal_spinal_cord1.02879286
93MP0002429_abnormal_blood_cell1.02232150
94MP0002653_abnormal_ependyma_morphology1.01145066
95MP0000358_abnormal_cell_content/1.00824954
96MP0001663_abnormal_digestive_system0.99778978
97MP0003221_abnormal_cardiomyocyte_apopto0.99769774
98MP0005584_abnormal_enzyme/coenzyme_acti0.99590771
99MP0002722_abnormal_immune_system0.96468322
100MP0002102_abnormal_ear_morphology0.95439727
101MP0005448_abnormal_energy_balance0.95115917
102MP0002132_abnormal_respiratory_system0.94661865
103MP0005000_abnormal_immune_tolerance0.94572446
104MP0005410_abnormal_fertilization0.92824413
105MP0000681_abnormal_thyroid_gland0.92673538
106MP0001529_abnormal_vocalization0.91664400
107MP0009379_abnormal_foot_pigmentation0.91418532
108MP0002148_abnormal_hypersensitivity_rea0.90829387
109MP0009785_altered_susceptibility_to0.90608084
110MP0000685_abnormal_immune_system0.90167948
111MP0002693_abnormal_pancreas_physiology0.90023693
112MP0001348_abnormal_lacrimal_gland0.87535564
113MP0008874_decreased_physiological_sensi0.85456113
114MP0002882_abnormal_neuron_morphology0.85195535
115MP0005360_urolithiasis0.84490492
116MP0004924_abnormal_behavior0.84264304
117MP0005386_behavior/neurological_phenoty0.84264304
118MP0010155_abnormal_intestine_physiology0.82476501
119MP0000604_amyloidosis0.82009989
120MP0002398_abnormal_bone_marrow0.81662189
121MP0002837_dystrophic_cardiac_calcinosis0.81478160
122MP0001944_abnormal_pancreas_morphology0.80727852
123MP0002069_abnormal_eating/drinking_beha0.80516381
124MP0001502_abnormal_circadian_rhythm0.79824088
125MP0002723_abnormal_immune_serum0.78728742
126MP0003718_maternal_effect0.78207241
127MP0002066_abnormal_motor_capabilities/c0.77023662
128MP0001853_heart_inflammation0.76830042
129MP0006082_CNS_inflammation0.76741200
130MP0004019_abnormal_vitamin_homeostasis0.76681493
131MP0005645_abnormal_hypothalamus_physiol0.75732116
132MP0003123_paternal_imprinting0.75609465
133MP0003183_abnormal_peptide_metabolism0.74990437
134MP0009765_abnormal_xenobiotic_induced0.74593463
135MP0008469_abnormal_protein_level0.74257090
136MP0005075_abnormal_melanosome_morpholog0.74175183
137MP0005535_abnormal_body_temperature0.73934067
138MP0005394_taste/olfaction_phenotype0.73413027
139MP0002078_abnormal_glucose_homeostasis0.72776910
140MP0005671_abnormal_response_to0.72600733
141MP0002405_respiratory_system_inflammati0.71335032
142MP0001845_abnormal_inflammatory_respons0.71277704
143MP0003763_abnormal_thymus_physiology0.71040098
144MP0005025_abnormal_response_to0.69552192
145MP0008875_abnormal_xenobiotic_pharmacok0.69447724

Predicted human phenotypes

RankGene SetZ-score
1Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.74944437
2Decreased activity of mitochondrial respiratory chain (HP:0008972)4.74944437
3Myokymia (HP:0002411)3.88770110
4Abnormality of cells of the erythroid lineage (HP:0012130)3.75516872
5Abnormal number of erythroid precursors (HP:0012131)3.61809697
6Abnormality of glycolipid metabolism (HP:0010969)3.59712194
7Abnormality of liposaccharide metabolism (HP:0010968)3.59712194
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.59712194
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.43757856
10Hepatocellular necrosis (HP:0001404)3.27196006
11Poor suck (HP:0002033)3.23098059
12Increased cerebral lipofuscin (HP:0011813)3.19902066
13Chronic obstructive pulmonary disease (HP:0006510)3.18413595
14Obstructive lung disease (HP:0006536)3.18413595
15Abnormality of magnesium homeostasis (HP:0004921)3.12533656
16Agammaglobulinemia (HP:0004432)3.11433700
17Visual hallucinations (HP:0002367)3.04699531
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.98694591
19Increased neuronal autofluorescent lipopigment (HP:0002074)2.97512244
20Gout (HP:0001997)2.93698761
21Mediastinal lymphadenopathy (HP:0100721)2.91962782
22Decreased electroretinogram (ERG) amplitude (HP:0000654)2.91156208
23Hepatic necrosis (HP:0002605)2.90054711
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.88860787
25Dysostosis multiplex (HP:0000943)2.88491595
26Polyphagia (HP:0002591)2.82132948
27Ragged-red muscle fibers (HP:0003200)2.80716060
28Emotional lability (HP:0000712)2.77930440
29Elevated erythrocyte sedimentation rate (HP:0003565)2.77128867
30Delusions (HP:0000746)2.76961758
31Failure to thrive in infancy (HP:0001531)2.72529955
32Vacuolated lymphocytes (HP:0001922)2.70749436
33Mesangial abnormality (HP:0001966)2.70306675
34Increased serum lactate (HP:0002151)2.67754751
35Mitochondrial inheritance (HP:0001427)2.56942640
36Progressive microcephaly (HP:0000253)2.51462403
37Abnormal mitochondria in muscle tissue (HP:0008316)2.51378146
38Supranuclear gaze palsy (HP:0000605)2.48662194
39Reduced antithrombin III activity (HP:0001976)2.48507794
40Acute necrotizing encephalopathy (HP:0006965)2.47842718
41Large eyes (HP:0001090)2.43629386
42Renal Fanconi syndrome (HP:0001994)2.43386268
43Microretrognathia (HP:0000308)2.39645670
44Abnormality of macrophages (HP:0004311)2.39392691
45Lactic acidosis (HP:0003128)2.37670744
46Systemic lupus erythematosus (HP:0002725)2.36223894
47Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34203486
48Loss of speech (HP:0002371)2.31849545
49Cerebral palsy (HP:0100021)2.31352166
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.31246221
51Reticulocytopenia (HP:0001896)2.31189882
52Dicarboxylic aciduria (HP:0003215)2.30182854
53Abnormality of dicarboxylic acid metabolism (HP:0010995)2.30182854
54Thrombocytosis (HP:0001894)2.29665325
55Deep palmar crease (HP:0006191)2.28146504
56Severe visual impairment (HP:0001141)2.28031060
57Split foot (HP:0001839)2.27450582
58Increased intramyocellular lipid droplets (HP:0012240)2.25486246
59Recurrent fungal infections (HP:0002841)2.24643174
60Hypomagnesemia (HP:0002917)2.23305646
61Meningitis (HP:0001287)2.22248384
62Abnormal hair whorl (HP:0010721)2.21715173
63Late onset (HP:0003584)2.20858057
64Cellulitis (HP:0100658)2.20844366
65Increased CSF lactate (HP:0002490)2.16543982
66Hepatosplenomegaly (HP:0001433)2.16507195
67Eczematoid dermatitis (HP:0000976)2.16430810
68Prolonged neonatal jaundice (HP:0006579)2.16238043
69Myositis (HP:0100614)2.14866971
70Exertional dyspnea (HP:0002875)2.13920634
71Petechiae (HP:0000967)2.11647919
723-Methylglutaconic aciduria (HP:0003535)2.10215338
73Respiratory failure (HP:0002878)2.09212773
74Type II lissencephaly (HP:0007260)2.07902842
75Progressive macrocephaly (HP:0004481)2.07814668
76Purpura (HP:0000979)2.06295706
77Cortical visual impairment (HP:0100704)2.06190591
78Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06018215
79Abnormality of polysaccharide metabolism (HP:0011012)2.06018215
80Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06018215
81Acute encephalopathy (HP:0006846)2.05486260
82Increased muscle lipid content (HP:0009058)2.05440389
83Hypoventilation (HP:0002791)2.04696270
84Increased serum ferritin (HP:0003281)2.03997467
85Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03744324
86Hypoglycemic seizures (HP:0002173)2.01211258
87Hyperthyroidism (HP:0000836)2.00861894
88Recurrent abscess formation (HP:0002722)2.00807055
89Hypertensive crisis (HP:0100735)2.00602821
90Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00072506
91Mutism (HP:0002300)1.99256813
92Neuronal loss in central nervous system (HP:0002529)1.98569004
93Death in infancy (HP:0001522)1.96419862
94Esotropia (HP:0000565)1.96166303
95Chronic mucocutaneous candidiasis (HP:0002728)1.95803590
96Recurrent cutaneous fungal infections (HP:0011370)1.95803590
97Abnormality of pain sensation (HP:0010832)1.93767156
98Impaired pain sensation (HP:0007328)1.93767156
99Pallor (HP:0000980)1.92276299
100Focal motor seizures (HP:0011153)1.92275051
101Panhypogammaglobulinemia (HP:0003139)1.91351372
102Exercise intolerance (HP:0003546)1.90333018
103Gliosis (HP:0002171)1.90302107
104Cerebral edema (HP:0002181)1.89543681
105Opisthotonus (HP:0002179)1.89496183
106Recurrent bacterial skin infections (HP:0005406)1.88540122
107Progressive neurologic deterioration (HP:0002344)1.88504263
108Increased IgE level (HP:0003212)1.86868039
109Ankle clonus (HP:0011448)1.86546014
110Restlessness (HP:0000711)1.86419290
111Amyloidosis (HP:0011034)1.86304491
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86055844
113Abnormality of alanine metabolism (HP:0010916)1.86055844
114Hyperalaninemia (HP:0003348)1.86055844
115Axonal loss (HP:0003447)1.85649814
116Stomatitis (HP:0010280)1.85589238
117Oligomenorrhea (HP:0000876)1.85278103
118Craniofacial dystonia (HP:0012179)1.85216655
119Optic disc pallor (HP:0000543)1.83368959
120Hypercortisolism (HP:0001578)1.83138424
121Mucopolysacchariduria (HP:0008155)1.82586584
122Urinary glycosaminoglycan excretion (HP:0003541)1.82586584
123Cholecystitis (HP:0001082)1.81437328
124Abnormal gallbladder physiology (HP:0012438)1.81437328
125Focal dystonia (HP:0004373)1.81358154
126Abnormality of reticulocytes (HP:0004312)1.80993645
127Abnormal eating behavior (HP:0100738)1.80747163
128Torticollis (HP:0000473)1.78473037
129Thoracic kyphosis (HP:0002942)1.77360118
130Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76339035
131Abnormal protein N-linked glycosylation (HP:0012347)1.76339035
132Abnormal protein glycosylation (HP:0012346)1.76339035
133Abnormal glycosylation (HP:0012345)1.76339035
134Agitation (HP:0000713)1.74756480
135Abnormality of fatty-acid metabolism (HP:0004359)1.74700566
136Growth hormone excess (HP:0000845)1.74279798
137Symptomatic seizures (HP:0011145)1.74100080
138Cerebral hypomyelination (HP:0006808)1.73278255
139Unsteady gait (HP:0002317)1.73048437
140Hypokinesia (HP:0002375)1.72817701
141Focal seizures (HP:0007359)1.70318806
142Macrocytic anemia (HP:0001972)1.69996991
143Neuroendocrine neoplasm (HP:0100634)1.69825347
144Abnormality of the motor neurons (HP:0002450)1.69677804
145Abnormal neuron morphology (HP:0012757)1.69677804
146Retinal dysplasia (HP:0007973)1.69178794
147Dysautonomia (HP:0002459)1.69176653
148Lipid accumulation in hepatocytes (HP:0006561)1.68424893
149Microvesicular hepatic steatosis (HP:0001414)1.68369387
150Broad distal phalanx of finger (HP:0009836)1.68081180
151Type I transferrin isoform profile (HP:0003642)1.68015153
152CNS demyelination (HP:0007305)1.67524312
153Generalized hypopigmentation (HP:0007513)1.67108317
154Absence seizures (HP:0002121)1.67045085
155Hyperphosphaturia (HP:0003109)1.66980556
156Death in childhood (HP:0003819)1.66811719
157Increased hepatocellular lipid droplets (HP:0006565)1.63370987
158Generalized aminoaciduria (HP:0002909)1.58971440
159Vertebral compression fractures (HP:0002953)1.58897325

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF3.68365919
2MAP3K93.67658430
3NME23.47901206
4MAP3K123.04060813
5KSR23.03160005
6VRK22.86691855
7STK162.58797376
8ERN12.52339269
9KSR12.46911362
10CAMKK22.43954937
11RAF12.18768147
12SCYL22.15835292
13NTRK32.14899589
14BUB12.06699769
15SIK32.03362176
16MAP4K22.03207656
17TESK21.99395860
18FGFR41.87569695
19MAP3K131.73759590
20BRAF1.58545220
21MINK11.54654667
22DYRK21.54175707
23MARK11.47599964
24TAOK31.45229745
25NME11.43210785
26PIM21.41839173
27MAP3K111.38819502
28TAOK11.38433404
29RIPK41.37713773
30PAK61.37318937
31CDK191.33070344
32DYRK31.31907416
33CAMKK11.29963286
34DAPK11.28534005
35GRK51.26985240
36IRAK21.26509256
37LIMK11.24965352
38EPHA41.23128208
39IRAK31.18528571
40TESK11.16875144
41DAPK21.16275215
42IKBKB1.12303465
43WNK31.12148418
44TAOK21.08385025
45DAPK31.07883378
46ZAP701.06636033
47MUSK1.03057004
48CSNK1G31.02783277
49MAPKAPK31.00390429
50AURKA0.99625978
51KIT0.98596769
52SYK0.92632120
53MAP3K20.91458504
54KDR0.91366625
55MAP2K60.91249644
56MAP2K70.89834851
57MAP2K30.89212926
58BCKDK0.88467421
59IKBKE0.87020193
60TXK0.87014316
61CSNK1G20.85821640
62CSF1R0.80992925
63MAP2K10.79990364
64TBK10.79305877
65CCNB10.78588770
66CDK140.77995076
67MOS0.77605159
68PASK0.77432027
69CDK180.75095639
70MAPK130.74535720
71NTRK10.74373095
72RPS6KA50.72696159
73LYN0.72290169
74CAMK10.71682906
75PRKCI0.71655131
76RET0.71633788
77UHMK10.71068059
78GRK60.67633401
79CDK11A0.67410671
80CDK150.66498558
81CDK50.65686460
82MATK0.64450612
83IRAK40.64321580
84LRRK20.64038513
85MAP3K10.62829527
86BRSK10.62391684
87MAP2K20.62330814
88RPS6KL10.60966809
89RPS6KC10.60966809
90PRKCG0.59691665
91TLK10.59137243
92GRK70.57785807
93RPS6KA60.53720129
94FES0.53528632
95CSNK1A1L0.53167818
96ADRBK20.52799099
97SRPK10.52612665
98PRKG20.52393738
99MAP3K50.50818928
100MAPK40.50592634
101CSNK1G10.49301646
102TYK20.49194856
103PDPK10.49113856
104SIK20.48883916
105DYRK1A0.48614188
106MAP2K40.47989793
107MAPK150.47744995
108PRKCZ0.46946150
109TRIB30.46714798
110RPS6KA20.46193374
111BTK0.44456383
112FLT30.43301368
113BMPR20.42061503
114LCK0.41499080
115TNIK0.40887551
116MAP4K10.40496379
117MAP3K140.40063243
118CAMK2G0.39953588
119RPS6KA40.39860333
120CSK0.39556184
121PDK10.39243256
122DYRK1B0.39060425
123NTRK20.38717081
124VRK10.38692089
125PRKD30.38242873
126ABL20.37799459
127PIM10.36988788
128MARK30.36374568
129HCK0.36016691
130SGK4940.33815509
131SGK2230.33815509
132BLK0.33711650
133TNK20.33645568
134PRKCD0.32942651
135PRPF4B0.31332750
136JAK30.30975414
137INSRR0.30606679
138NUAK10.30587150

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.39560755
2Proteasome_Homo sapiens_hsa030503.37013792
3Ribosome_Homo sapiens_hsa030103.18882167
4Oxidative phosphorylation_Homo sapiens_hsa001902.99155738
5Asthma_Homo sapiens_hsa053102.77823920
6Parkinsons disease_Homo sapiens_hsa050122.49418355
7Protein export_Homo sapiens_hsa030602.43018243
8Allograft rejection_Homo sapiens_hsa053302.41796732
9Folate biosynthesis_Homo sapiens_hsa007902.41162164
10Other glycan degradation_Homo sapiens_hsa005112.37640638
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.34571375
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.24911232
13Sulfur relay system_Homo sapiens_hsa041222.22958618
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.16885960
15Collecting duct acid secretion_Homo sapiens_hsa049662.16068252
16Cyanoamino acid metabolism_Homo sapiens_hsa004602.09584287
17Autoimmune thyroid disease_Homo sapiens_hsa053202.08857330
18Primary immunodeficiency_Homo sapiens_hsa053402.03424649
19Type I diabetes mellitus_Homo sapiens_hsa049402.00449181
20Graft-versus-host disease_Homo sapiens_hsa053321.98224257
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87941738
22Alzheimers disease_Homo sapiens_hsa050101.84929713
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.84490558
24Huntingtons disease_Homo sapiens_hsa050161.84389683
25Vibrio cholerae infection_Homo sapiens_hsa051101.79661151
26Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.77884746
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.76071381
28Staphylococcus aureus infection_Homo sapiens_hsa051501.70660246
29Pyrimidine metabolism_Homo sapiens_hsa002401.64770375
30DNA replication_Homo sapiens_hsa030301.61350498
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.60325186
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59912876
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.58718605
34Regulation of autophagy_Homo sapiens_hsa041401.56857901
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52109499
36RNA polymerase_Homo sapiens_hsa030201.51039336
37Antigen processing and presentation_Homo sapiens_hsa046121.41848507
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36216652
39Tuberculosis_Homo sapiens_hsa051521.34009717
40Nicotine addiction_Homo sapiens_hsa050331.33919280
41Thyroid cancer_Homo sapiens_hsa052161.22040802
42Fatty acid elongation_Homo sapiens_hsa000621.21363818
43N-Glycan biosynthesis_Homo sapiens_hsa005101.20544766
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.17570741
45SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17320225
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.13568495
47VEGF signaling pathway_Homo sapiens_hsa043701.12765769
48Shigellosis_Homo sapiens_hsa051311.10252332
49Insulin secretion_Homo sapiens_hsa049111.07136816
50Long-term potentiation_Homo sapiens_hsa047201.04882468
51Sulfur metabolism_Homo sapiens_hsa009201.03287622
52Galactose metabolism_Homo sapiens_hsa000521.01930634
53Viral myocarditis_Homo sapiens_hsa054161.01330287
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.00183600
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97419587
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97205876
57Base excision repair_Homo sapiens_hsa034100.96112970
58Vitamin B6 metabolism_Homo sapiens_hsa007500.94137581
59Osteoclast differentiation_Homo sapiens_hsa043800.93140795
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.93097936
61Taste transduction_Homo sapiens_hsa047420.91855514
62Caffeine metabolism_Homo sapiens_hsa002320.90881739
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.90300327
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89709711
65Pertussis_Homo sapiens_hsa051330.86894484
66GABAergic synapse_Homo sapiens_hsa047270.86433315
67Circadian entrainment_Homo sapiens_hsa047130.85757472
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.85289443
69Phenylalanine metabolism_Homo sapiens_hsa003600.85267912
70Dopaminergic synapse_Homo sapiens_hsa047280.84225744
71Fructose and mannose metabolism_Homo sapiens_hsa000510.83910148
72Systemic lupus erythematosus_Homo sapiens_hsa053220.82156446
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81658439
74Phototransduction_Homo sapiens_hsa047440.81381813
75Oocyte meiosis_Homo sapiens_hsa041140.80769232
76Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.80387401
77Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80379636
78Amphetamine addiction_Homo sapiens_hsa050310.79953120
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.77803697
80Carbon metabolism_Homo sapiens_hsa012000.76529746
81Biosynthesis of amino acids_Homo sapiens_hsa012300.74712653
82Leishmaniasis_Homo sapiens_hsa051400.73102200
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72925529
84Hematopoietic cell lineage_Homo sapiens_hsa046400.72302487
85Peroxisome_Homo sapiens_hsa041460.72251350
86Cocaine addiction_Homo sapiens_hsa050300.71941372
87Cholinergic synapse_Homo sapiens_hsa047250.71117294
88Cardiac muscle contraction_Homo sapiens_hsa042600.70344721
89Purine metabolism_Homo sapiens_hsa002300.70093325
90Lysosome_Homo sapiens_hsa041420.69871070
91Non-small cell lung cancer_Homo sapiens_hsa052230.68163702
92Alcoholism_Homo sapiens_hsa050340.67534878
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.67461211
94Glutamatergic synapse_Homo sapiens_hsa047240.66977420
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66959486
96Olfactory transduction_Homo sapiens_hsa047400.66179894
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64796628
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63880528
99Glutathione metabolism_Homo sapiens_hsa004800.63405586
100Bladder cancer_Homo sapiens_hsa052190.61752360
101Herpes simplex infection_Homo sapiens_hsa051680.61012860
102Arachidonic acid metabolism_Homo sapiens_hsa005900.58806368
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57418219
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57233309
105Pentose phosphate pathway_Homo sapiens_hsa000300.56926725
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56324136
107Spliceosome_Homo sapiens_hsa030400.56185966
108Serotonergic synapse_Homo sapiens_hsa047260.54380525
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52915934
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52705086
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.52584170
112Mismatch repair_Homo sapiens_hsa034300.51950524
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50923004
114Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.50692211
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50537728
116Tyrosine metabolism_Homo sapiens_hsa003500.50392897
117Prolactin signaling pathway_Homo sapiens_hsa049170.49458870
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48317015
119Arginine and proline metabolism_Homo sapiens_hsa003300.47971375
120Type II diabetes mellitus_Homo sapiens_hsa049300.47913169
121Insulin signaling pathway_Homo sapiens_hsa049100.47846435
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46900339
123Nucleotide excision repair_Homo sapiens_hsa034200.46417308
124Prion diseases_Homo sapiens_hsa050200.46275583
125Morphine addiction_Homo sapiens_hsa050320.45948480
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44683923
127Endocytosis_Homo sapiens_hsa041440.44149005
128Metabolic pathways_Homo sapiens_hsa011000.43548842
129Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.43100159
130Long-term depression_Homo sapiens_hsa047300.42531708
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41777825
132Legionellosis_Homo sapiens_hsa051340.41713832
133Toxoplasmosis_Homo sapiens_hsa051450.41264749
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.40314781
135Influenza A_Homo sapiens_hsa051640.39621274
136NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39406951
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.39334618
138Phagosome_Homo sapiens_hsa041450.38742636
139Gap junction_Homo sapiens_hsa045400.38170234
140Acute myeloid leukemia_Homo sapiens_hsa052210.37584285
141Oxytocin signaling pathway_Homo sapiens_hsa049210.37222048
142Salmonella infection_Homo sapiens_hsa051320.34884565
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.34172540
144Renin-angiotensin system_Homo sapiens_hsa046140.33859881
145Choline metabolism in cancer_Homo sapiens_hsa052310.33713144
146Salivary secretion_Homo sapiens_hsa049700.33121990
147Epstein-Barr virus infection_Homo sapiens_hsa051690.32781524
148Tryptophan metabolism_Homo sapiens_hsa003800.32062954
149Rheumatoid arthritis_Homo sapiens_hsa053230.31236853
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.29935570

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