FBXL16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.32242826
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.19012083
3locomotory exploration behavior (GO:0035641)6.17727542
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.13497920
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.56549078
6vocalization behavior (GO:0071625)5.41855945
7regulation of synapse structural plasticity (GO:0051823)5.37547016
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.31787655
9L-amino acid import (GO:0043092)5.18873056
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.17056388
11synaptic vesicle exocytosis (GO:0016079)5.14551261
12regulation of glutamate receptor signaling pathway (GO:1900449)5.10312511
13regulation of long-term neuronal synaptic plasticity (GO:0048169)5.04422687
14regulation of neuronal synaptic plasticity (GO:0048168)4.99831426
15regulation of synaptic vesicle exocytosis (GO:2000300)4.92798851
16cerebellar granule cell differentiation (GO:0021707)4.80308277
17glutamate secretion (GO:0014047)4.77211448
18amino acid import (GO:0043090)4.67399857
19regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.54118001
20dendritic spine morphogenesis (GO:0060997)4.53303388
21exploration behavior (GO:0035640)4.49799639
22neuronal action potential propagation (GO:0019227)4.49360190
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.47913502
24protein localization to synapse (GO:0035418)4.44233179
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.42495016
26regulation of synaptic vesicle transport (GO:1902803)4.42154096
27neurotransmitter secretion (GO:0007269)4.40090589
28prepulse inhibition (GO:0060134)4.39739545
29neurotransmitter-gated ion channel clustering (GO:0072578)4.39389467
30negative regulation of synaptic transmission, GABAergic (GO:0032229)4.24601493
31cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.22688515
32regulation of dendritic spine morphogenesis (GO:0061001)4.21975365
33long-term memory (GO:0007616)4.16970585
34potassium ion homeostasis (GO:0055075)4.14099956
35positive regulation of membrane potential (GO:0045838)4.12971339
36negative regulation of dendrite morphogenesis (GO:0050774)4.12359813
37synaptic transmission, glutamatergic (GO:0035249)4.12152388
38layer formation in cerebral cortex (GO:0021819)4.11842331
39auditory behavior (GO:0031223)4.11595054
40axon ensheathment in central nervous system (GO:0032291)4.04501369
41central nervous system myelination (GO:0022010)4.04501369
42regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04056953
43positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.03909138
44neuromuscular process controlling balance (GO:0050885)4.03434244
45positive regulation of synaptic transmission, GABAergic (GO:0032230)4.01217744
46neuron-neuron synaptic transmission (GO:0007270)4.00540416
47potassium ion import (GO:0010107)3.97664373
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.92224495
49regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91544682
50postsynaptic membrane organization (GO:0001941)3.90074379
51synaptic transmission, dopaminergic (GO:0001963)3.87152106
52positive regulation of neurotransmitter transport (GO:0051590)3.86343340
53regulation of synapse maturation (GO:0090128)3.86232139
54regulation of synaptic plasticity (GO:0048167)3.85443418
55G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.84938472
56cerebellar Purkinje cell differentiation (GO:0021702)3.84552140
57glutamate receptor signaling pathway (GO:0007215)3.80385302
58gamma-aminobutyric acid transport (GO:0015812)3.75698610
59regulation of postsynaptic membrane potential (GO:0060078)3.75255908
60activation of protein kinase A activity (GO:0034199)3.74710193
61response to auditory stimulus (GO:0010996)3.71306443
62adenosine receptor signaling pathway (GO:0001973)3.71272970
63positive regulation of neurotransmitter secretion (GO:0001956)3.66978305
64striatum development (GO:0021756)3.64787915
65cell communication by electrical coupling (GO:0010644)3.63806322
66neuron cell-cell adhesion (GO:0007158)3.59390100
67regulation of synaptic transmission, glutamatergic (GO:0051966)3.58465009
68transmission of nerve impulse (GO:0019226)3.58236772
69neuronal ion channel clustering (GO:0045161)3.55678697
70cellular potassium ion homeostasis (GO:0030007)3.53600517
71adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.51073153
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.50566415
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50226859
74cellular sodium ion homeostasis (GO:0006883)3.47534474
75long-term synaptic potentiation (GO:0060291)3.47359349
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.44283486
77dendritic spine organization (GO:0097061)3.44127068
78neurotransmitter transport (GO:0006836)3.43490207
79glycine transport (GO:0015816)3.43170309
80response to amphetamine (GO:0001975)3.42359380
81regulation of female receptivity (GO:0045924)3.42334769
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.41786023
83acidic amino acid transport (GO:0015800)3.41104882
84behavioral response to cocaine (GO:0048148)3.37641979
85regulation of neurotransmitter secretion (GO:0046928)3.37203886
86dopamine receptor signaling pathway (GO:0007212)3.36088895
87regulation of dendritic spine development (GO:0060998)3.34727595
88proline transport (GO:0015824)3.34044497
89sodium ion export (GO:0071436)3.31620874
90vesicle docking involved in exocytosis (GO:0006904)3.31610117
91regulation of neurotransmitter levels (GO:0001505)3.29812562
92positive regulation of synapse maturation (GO:0090129)3.29643908
93regulation of neurotransmitter transport (GO:0051588)3.28613850
94negative regulation of cytosolic calcium ion concentration (GO:0051481)3.26503563
95membrane hyperpolarization (GO:0060081)3.26255276
96neurotransmitter uptake (GO:0001504)3.25954769
97neuromuscular process controlling posture (GO:0050884)3.25180453
98neuromuscular synaptic transmission (GO:0007274)3.24181632
99regulation of vesicle fusion (GO:0031338)3.22974283
100regulation of glutamate secretion (GO:0014048)3.22180131
101membrane depolarization (GO:0051899)3.20747922
102synaptic vesicle transport (GO:0048489)3.20219348
103establishment of synaptic vesicle localization (GO:0097480)3.20219348
104positive regulation of dendritic spine development (GO:0060999)3.19949515
105synaptic transmission (GO:0007268)3.18945934
106regulation of exocytosis (GO:0017157)3.18428702
107positive regulation of synaptic transmission (GO:0050806)3.16531894
108regulation of voltage-gated calcium channel activity (GO:1901385)3.16379484
109learning (GO:0007612)3.16257441
110visual learning (GO:0008542)3.15977390
111positive regulation of dendrite development (GO:1900006)3.15864489
112regulation of ARF protein signal transduction (GO:0032012)3.15540640
113behavioral defense response (GO:0002209)3.14763794
114behavioral fear response (GO:0001662)3.14763794
115mechanosensory behavior (GO:0007638)3.11049553
116membrane depolarization during action potential (GO:0086010)3.10274688
117neuromuscular process (GO:0050905)3.10183125
118cell differentiation in hindbrain (GO:0021533)3.06249137
119synaptic vesicle endocytosis (GO:0048488)3.06099807
120dicarboxylic acid transport (GO:0006835)3.05662551
121signal release (GO:0023061)3.04782731
122female mating behavior (GO:0060180)3.04496076
123vesicle transport along microtubule (GO:0047496)3.04436771
124positive regulation of dendritic spine morphogenesis (GO:0061003)3.03183593
125vesicle docking (GO:0048278)3.02552706
126regulation of synaptic transmission (GO:0050804)3.00910732
127regulation of synaptic transmission, GABAergic (GO:0032228)3.00400288
128visual behavior (GO:0007632)3.00151955
129chemosensory behavior (GO:0007635)3.00041221
130response to histamine (GO:0034776)2.98179154
131mating behavior (GO:0007617)2.97189482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70838886
2* RARB_27405468_Chip-Seq_BRAIN_Mouse3.52381232
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.16941750
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.10259144
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07961641
6GBX2_23144817_ChIP-Seq_PC3_Human2.87885547
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.86090117
8DROSHA_22980978_ChIP-Seq_HELA_Human2.85940502
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.82638420
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.82638420
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.79051726
12* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.65313662
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64549185
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.63698393
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.63172940
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54000862
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.48720492
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41282018
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.40528488
20EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.39895608
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.39229293
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.35865644
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.34586840
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.27946126
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.10032863
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93204185
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.89661444
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81344089
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.80021790
30AR_21572438_ChIP-Seq_LNCaP_Human1.77324719
31DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53128336
32* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48036134
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47529420
34LXR_22292898_ChIP-Seq_THP-1_Human1.41691891
35* KDM2B_26808549_Chip-Seq_K562_Human1.39904343
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39841636
37SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.38733021
38CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38064676
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.37837352
40SMAD4_21799915_ChIP-Seq_A2780_Human1.36695816
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31783741
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31526312
43* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31268971
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30934013
45* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.28962882
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.28242830
47CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25847716
48GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24708995
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.23066788
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20241477
51* AR_19668381_ChIP-Seq_PC3_Human1.20107691
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18822220
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18821544
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16694086
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.16626279
56ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16543075
57* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16042777
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13705371
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13075927
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12260562
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.11169840
62SMC4_20622854_ChIP-Seq_HELA_Human1.10659305
63PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10481642
64STAT3_23295773_ChIP-Seq_U87_Human1.09670287
65TAF15_26573619_Chip-Seq_HEK293_Human1.09340814
66PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09295157
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08861308
68* OCT4_19829295_ChIP-Seq_ESCs_Human1.08235109
69CTCF_27219007_Chip-Seq_Bcells_Human1.05258786
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04731985
71VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04645286
72* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03370859
73ZNF274_21170338_ChIP-Seq_K562_Hela1.02445054
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.02240844
75SMAD3_21741376_ChIP-Seq_HESCs_Human1.01057106
76GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00825832
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00580412
78AR_25329375_ChIP-Seq_VCAP_Human1.00211873
79DPY_21335234_ChIP-Seq_ESCs_Mouse0.99717961
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99310391
81TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98567074
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.97332756
83CREB1_26743006_Chip-Seq_LNCaP_Human0.96610117
84YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96446702
85SMAD_19615063_ChIP-ChIP_OVARY_Human0.95939715
86TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95682595
87* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95249449
88P300_19829295_ChIP-Seq_ESCs_Human0.95115077
89* TET1_21490601_ChIP-Seq_MESCs_Mouse0.95019219
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94131244
91TCF4_23295773_ChIP-Seq_U87_Human0.93802556
92* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93724892
93KDM2B_26808549_Chip-Seq_DND41_Human0.93682847
94* P68_20966046_ChIP-Seq_HELA_Human0.92669507
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.91978037
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91922447
97SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91223019
98* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90531435
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.90381155
100KLF4_19829295_ChIP-Seq_ESCs_Human0.90024062
101RXR_22108803_ChIP-Seq_LS180_Human0.88645939
102RNF2_27304074_Chip-Seq_NSC_Mouse0.88396017
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.88057637
104TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86772934
105AHR_22903824_ChIP-Seq_MCF-7_Human0.85688518
106TP53_20018659_ChIP-ChIP_R1E_Mouse0.84840469
107KDM2B_26808549_Chip-Seq_SUP-B15_Human0.84781020
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.84367894
109PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.84225714
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83584151
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83285182
112SMAD4_21741376_ChIP-Seq_ESCs_Human0.83127591
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.82694963
114ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82443783
115SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81958158
116CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81941949
117RUNX2_22187159_ChIP-Seq_PCA_Human0.81741092
118EGR1_19032775_ChIP-ChIP_M12_Human0.80357527
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.80322036
120KDM2B_26808549_Chip-Seq_JURKAT_Human0.80166264
121CBX2_27304074_Chip-Seq_ESCs_Mouse0.79946653
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79691694
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.79627550
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79274909
125RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79183973
126MYC_19915707_ChIP-ChIP_AK7_Human0.78831294
127CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78581290
128TET1_21451524_ChIP-Seq_MESCs_Mouse0.77623850
129TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77156347
130TP53_16413492_ChIP-PET_HCT116_Human0.77126324
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.74300864
132MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.73982627
133CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.72906694
134TP53_23651856_ChIP-Seq_MEFs_Mouse0.71036457

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.21671161
2MP0002822_catalepsy5.84715873
3MP0003880_abnormal_central_pattern4.36877243
4MP0003635_abnormal_synaptic_transmissio4.33378943
5MP0004270_analgesia3.75332600
6MP0009745_abnormal_behavioral_response3.65284261
7MP0002063_abnormal_learning/memory/cond3.53780203
8MP0002064_seizures3.18537931
9MP0009046_muscle_twitch2.89533693
10MP0002572_abnormal_emotion/affect_behav2.83842668
11MP0001486_abnormal_startle_reflex2.68354864
12MP0001968_abnormal_touch/_nociception2.67548674
13MP0005423_abnormal_somatic_nervous2.63009229
14MP0002272_abnormal_nervous_system2.59922495
15MP0002734_abnormal_mechanical_nocicepti2.43245832
16MP0002909_abnormal_adrenal_gland2.35603728
17MP0001501_abnormal_sleep_pattern2.25179917
18MP0009780_abnormal_chondrocyte_physiolo2.07251108
19MP0005646_abnormal_pituitary_gland1.98213512
20MP0008569_lethality_at_weaning1.95197591
21MP0001970_abnormal_pain_threshold1.88283225
22MP0002733_abnormal_thermal_nociception1.85690456
23MP0002736_abnormal_nociception_after1.84925338
24MP0004811_abnormal_neuron_physiology1.82697263
25MP0001440_abnormal_grooming_behavior1.81182839
26MP0001529_abnormal_vocalization1.78700361
27MP0005386_behavior/neurological_phenoty1.75023081
28MP0004924_abnormal_behavior1.75023081
29MP0002557_abnormal_social/conspecific_i1.70944036
30MP0002735_abnormal_chemical_nociception1.66892591
31MP0003123_paternal_imprinting1.65080874
32MP0003329_amyloid_beta_deposits1.64569447
33MP0003879_abnormal_hair_cell1.63353366
34MP0002067_abnormal_sensory_capabilities1.62938201
35MP0004858_abnormal_nervous_system1.62591731
36MP0002184_abnormal_innervation1.47952437
37MP0001984_abnormal_olfaction1.45677603
38MP0004885_abnormal_endolymph1.45280003
39MP0000955_abnormal_spinal_cord1.43563447
40MP0003633_abnormal_nervous_system1.42861700
41MP0003075_altered_response_to1.41157827
42MP0003283_abnormal_digestive_organ1.40750486
43MP0002066_abnormal_motor_capabilities/c1.36624257
44MP0000778_abnormal_nervous_system1.29308506
45MP0000013_abnormal_adipose_tissue1.28419012
46MP0002882_abnormal_neuron_morphology1.28104362
47MP0003787_abnormal_imprinting1.19015749
48MP0001502_abnormal_circadian_rhythm1.15734276
49MP0005645_abnormal_hypothalamus_physiol1.15317658
50MP0008872_abnormal_physiological_respon1.15285501
51MP0001177_atelectasis1.15147274
52MP0008961_abnormal_basal_metabolism1.14759393
53MP0001905_abnormal_dopamine_level1.14477967
54MP0003631_nervous_system_phenotype1.12627393
55MP0005167_abnormal_blood-brain_barrier1.12539546
56MP0008874_decreased_physiological_sensi1.11668485
57MP0005409_darkened_coat_color1.08922929
58MP0001188_hyperpigmentation1.07277302
59MP0002069_abnormal_eating/drinking_beha1.00253944
60MP0001346_abnormal_lacrimal_gland0.99051245
61MP0002152_abnormal_brain_morphology0.98745377
62MP0005535_abnormal_body_temperature0.97546424
63MP0003690_abnormal_glial_cell0.95953129
64MP0010234_abnormal_vibrissa_follicle0.92099491
65MP0004142_abnormal_muscle_tone0.91629711
66MP0004085_abnormal_heartbeat0.91203127
67MP0002090_abnormal_vision0.89354363
68MP0006276_abnormal_autonomic_nervous0.87248440
69MP0000569_abnormal_digit_pigmentation0.87169220
70MP0000920_abnormal_myelination0.84592551
71MP0002229_neurodegeneration0.83684186
72MP0001348_abnormal_lacrimal_gland0.83581475
73MP0001986_abnormal_taste_sensitivity0.83429080
74MP0010386_abnormal_urinary_bladder0.83269973
75MP0004043_abnormal_pH_regulation0.82336053
76MP0000751_myopathy0.79812000
77MP0004147_increased_porphyrin_level0.77112341
78MP0005394_taste/olfaction_phenotype0.76217482
79MP0005499_abnormal_olfactory_system0.76217482
80MP0003634_abnormal_glial_cell0.75234684
81MP0003122_maternal_imprinting0.72802885
82MP0000604_amyloidosis0.71380757
83MP0008877_abnormal_DNA_methylation0.70560911
84MP0000631_abnormal_neuroendocrine_gland0.70249285
85MP0004145_abnormal_muscle_electrophysio0.68078375
86MP0003632_abnormal_nervous_system0.67879355
87MP0005551_abnormal_eye_electrophysiolog0.67461717
88MP0004130_abnormal_muscle_cell0.66317213
89MP0003183_abnormal_peptide_metabolism0.65464354
90MP0003172_abnormal_lysosome_physiology0.63554373
91MP0003137_abnormal_impulse_conducting0.62951425
92MP0001664_abnormal_digestion0.62028374
93MP0001485_abnormal_pinna_reflex0.58617985
94MP0004742_abnormal_vestibular_system0.58438965
95MP0000579_abnormal_nail_morphology0.57628625
96MP0004510_myositis0.56755554
97MP0001963_abnormal_hearing_physiology0.56725937
98MP0005166_decreased_susceptibility_to0.54378094
99MP0002638_abnormal_pupillary_reflex0.50699436
100MP0002752_abnormal_somatic_nervous0.50658644
101MP0010768_mortality/aging0.50238946
102MP0001943_abnormal_respiration0.49140080
103MP0001765_abnormal_ion_homeostasis0.48561199
104MP0003956_abnormal_body_size0.48491738
105MP0010770_preweaning_lethality0.48034940
106MP0002082_postnatal_lethality0.48034940
107MP0003121_genomic_imprinting0.47820696
108MP0004233_abnormal_muscle_weight0.46317394
109MP0000003_abnormal_adipose_tissue0.46138605
110MP0010769_abnormal_survival0.45854093
111MP0002873_normal_phenotype0.45438033
112MP0003861_abnormal_nervous_system0.45120354
113MP0004215_abnormal_myocardial_fiber0.44841012
114MP0000026_abnormal_inner_ear0.44594583
115MP0002169_no_abnormal_phenotype0.43982846
116MP0002234_abnormal_pharynx_morphology0.43653064
117MP0005623_abnormal_meninges_morphology0.43439662
118MP0003938_abnormal_ear_development0.42377473

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.78300928
2Focal motor seizures (HP:0011153)7.75847324
3Focal seizures (HP:0007359)5.81730080
4Visual hallucinations (HP:0002367)5.17868561
5Action tremor (HP:0002345)4.29541867
6Epileptic encephalopathy (HP:0200134)4.22697048
7Ankle clonus (HP:0011448)3.96432571
8Febrile seizures (HP:0002373)3.94385682
9Atonic seizures (HP:0010819)3.88844189
10Poor eye contact (HP:0000817)3.86789361
11Impaired vibration sensation in the lower limbs (HP:0002166)3.79259878
12Generalized tonic-clonic seizures (HP:0002069)3.76854579
13Absence seizures (HP:0002121)3.75530970
14Depression (HP:0000716)3.71360121
15Progressive cerebellar ataxia (HP:0002073)3.65566339
16Anxiety (HP:0000739)3.65537326
17Torticollis (HP:0000473)3.59629020
18Papilledema (HP:0001085)3.58182454
19Cerebral hypomyelination (HP:0006808)3.55186074
20Annular pancreas (HP:0001734)3.53021800
21Impaired social interactions (HP:0000735)3.47573070
22Abnormal social behavior (HP:0012433)3.47573070
23Dialeptic seizures (HP:0011146)3.45471141
24Broad-based gait (HP:0002136)3.44505157
25Dysdiadochokinesis (HP:0002075)3.40185475
26Gaze-evoked nystagmus (HP:0000640)3.34106638
27Supranuclear gaze palsy (HP:0000605)3.32696071
28Urinary bladder sphincter dysfunction (HP:0002839)3.30987218
29Focal dystonia (HP:0004373)3.27135292
30Resting tremor (HP:0002322)3.24409914
31Postural instability (HP:0002172)3.20946365
32Dysmetria (HP:0001310)3.20497167
33Craniofacial dystonia (HP:0012179)2.99775056
34Akinesia (HP:0002304)2.94347145
35Urinary urgency (HP:0000012)2.91900932
36Truncal ataxia (HP:0002078)2.90867770
37Abnormality of the lower motor neuron (HP:0002366)2.89629963
38Impaired smooth pursuit (HP:0007772)2.87831799
39Stereotypic behavior (HP:0000733)2.87663905
40Abnormal eating behavior (HP:0100738)2.84032339
41Ankyloglossia (HP:0010296)2.81027564
42Ventricular fibrillation (HP:0001663)2.77901325
43Intention tremor (HP:0002080)2.77158682
44Amblyopia (HP:0000646)2.74330068
45Pointed chin (HP:0000307)2.73088408
46Spastic gait (HP:0002064)2.72123778
47Scanning speech (HP:0002168)2.71036998
48Megalencephaly (HP:0001355)2.67036333
49Mutism (HP:0002300)2.65356928
50Bradykinesia (HP:0002067)2.63305901
51Peripheral hypomyelination (HP:0007182)2.62445454
52Impaired vibratory sensation (HP:0002495)2.57427917
53Dysmetric saccades (HP:0000641)2.57179721
54Sleep apnea (HP:0010535)2.56415324
55Diminished motivation (HP:0000745)2.52034471
56Abnormality of the corticospinal tract (HP:0002492)2.51195512
57Bundle branch block (HP:0011710)2.46181791
58Abnormality of ocular smooth pursuit (HP:0000617)2.45359414
59Hemiplegia (HP:0002301)2.44902592
60Spastic tetraparesis (HP:0001285)2.42887682
61Genetic anticipation (HP:0003743)2.42045658
62Hemiparesis (HP:0001269)2.41674096
63Hyperventilation (HP:0002883)2.34157391
64Neurofibrillary tangles (HP:0002185)2.32827122
65Abnormal EKG (HP:0003115)2.32139985
66Clonus (HP:0002169)2.30455202
67Choreoathetosis (HP:0001266)2.29075109
68Lower limb amyotrophy (HP:0007210)2.29066083
69Epileptiform EEG discharges (HP:0011182)2.27561253
70EEG with generalized epileptiform discharges (HP:0011198)2.24622557
71Prolonged QT interval (HP:0001657)2.23895716
72Insomnia (HP:0100785)2.23585302
73Progressive inability to walk (HP:0002505)2.21901161
74Cerebral inclusion bodies (HP:0100314)2.21863635
75Status epilepticus (HP:0002133)2.21112570
76Lower limb muscle weakness (HP:0007340)2.20350155
77Hypsarrhythmia (HP:0002521)2.18448127
78CNS hypomyelination (HP:0003429)2.15798335
79Obstructive sleep apnea (HP:0002870)2.13391955
80Polygenic inheritance (HP:0010982)2.11827650
81Increased circulating renin level (HP:0000848)2.11662546
82Limb dystonia (HP:0002451)2.11071535
83Excessive salivation (HP:0003781)2.09378627
84Drooling (HP:0002307)2.09378627
85Incomplete penetrance (HP:0003829)2.08905050
86Abnormality of binocular vision (HP:0011514)2.07606812
87Diplopia (HP:0000651)2.07606812
88Abnormality of the periventricular white matter (HP:0002518)2.06008672
89Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05422147
90Abnormality of oral frenula (HP:0000190)2.04354462
91Lower limb asymmetry (HP:0100559)2.03055769
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.96719425
93Degeneration of the lateral corticospinal tracts (HP:0002314)1.96719425
94Morphological abnormality of the pyramidal tract (HP:0002062)1.95905850
95Polyphagia (HP:0002591)1.95060708
96Fetal akinesia sequence (HP:0001989)1.95018208
97Neuronal loss in central nervous system (HP:0002529)1.94759179
98Gait ataxia (HP:0002066)1.93059388
99Termporal pattern (HP:0011008)1.92585474
100Insidious onset (HP:0003587)1.92585474
101Generalized myoclonic seizures (HP:0002123)1.91727753
102Spinal canal stenosis (HP:0003416)1.91606403
103Abnormality of saccadic eye movements (HP:0000570)1.90763363
104Rigidity (HP:0002063)1.89810826
105Split foot (HP:0001839)1.89366926
106Heart block (HP:0012722)1.87129072
107Memory impairment (HP:0002354)1.85996594
108Aplasia involving bones of the upper limbs (HP:0009823)1.85224956
109Aplasia of the phalanges of the hand (HP:0009802)1.85224956
110Aplasia involving bones of the extremities (HP:0009825)1.85224956
111Dementia (HP:0000726)1.84093501
112Absent speech (HP:0001344)1.82639617
113Pheochromocytoma (HP:0002666)1.81064925
114Tetraplegia (HP:0002445)1.79997292
115Bronchomalacia (HP:0002780)1.78503378
116Delusions (HP:0000746)1.75103203
117Upper limb amyotrophy (HP:0009129)1.73157595
118Distal upper limb amyotrophy (HP:0007149)1.73157595
119Slow saccadic eye movements (HP:0000514)1.73128490
120Atrioventricular block (HP:0001678)1.73058971
121Apathy (HP:0000741)1.72415093
122Rapidly progressive (HP:0003678)1.71717543
123Unsteady gait (HP:0002317)1.68576546

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.30978708
2NTRK34.30669181
3MAP3K93.86640149
4PRKD33.15610955
5DAPK23.09853863
6KSR22.72949939
7MINK12.43359160
8CAMKK12.37445617
9RIPK42.31236736
10MAP3K42.24787431
11PAK62.23382836
12NTRK12.10506471
13MARK12.00678438
14NTRK21.88469456
15ARAF1.74550159
16MAP2K71.69625293
17DAPK11.68536506
18KSR11.68103339
19MAP3K131.67478313
20CDK51.65461311
21MAP3K21.63642262
22FES1.57617851
23TAOK11.48648435
24STK381.41235439
25PRPF4B1.38214095
26TYRO31.37668564
27MAP2K41.36169110
28SIK21.30501799
29TNIK1.27168776
30CAMKK21.26965514
31UHMK11.13641555
32RAF11.11004792
33GRK51.10228901
34PINK11.06516573
35PRKCG1.05706242
36PRKCH1.05632731
37MAP3K121.05228421
38CAMK10.99820591
39SGK2230.95918785
40SGK4940.95918785
41STK110.94537679
42CDK190.92259085
43BMPR20.91491195
44ALK0.90458998
45PLK20.88282327
46MAPK120.87923616
47MAP3K10.86984005
48CDK150.85977447
49CDK180.85685873
50RIPK10.84341104
51RET0.84168292
52CDK140.80947273
53CAMK2A0.79786013
54SGK30.79720928
55SGK20.79353557
56MAPK130.78753453
57PDK10.78663597
58PTK2B0.78408139
59MARK20.77546251
60PDPK10.77541431
61MAP3K110.75070712
62CDK11A0.75058359
63SGK10.74382129
64BRSK10.73445055
65CAMK2B0.70358957
66TNK20.69952068
67NEK10.63166486
68LIMK10.62924422
69NEK60.62920681
70PKN10.61823419
71LMTK20.61020912
72PNCK0.60037933
73PAK30.58864209
74DAPK30.55459803
75RPS6KA30.54060986
76MAP2K10.53964038
77CAMK40.53850112
78PHKG10.52797283
79PHKG20.52797283
80PRKD20.49746441
81PRKCZ0.49657129
82TESK10.48585046
83CDC42BPA0.48397784
84FYN0.48212904
85MAPK100.46986371
86DMPK0.46806297
87DYRK1A0.46390723
88FGFR20.45044206
89PRKG20.44278369
90LATS20.43985789
91MAP3K70.43784586
92SCYL20.41535521
93TRIB30.40077821
94WNK10.40016902
95ROCK20.39345760
96MAP2K60.38370333
97IRAK20.37496629
98CAMK2G0.37286708
99CAMK2D0.37067321
100OXSR10.36952659
101BRAF0.36889628
102CASK0.36648034
103PRKCE0.36175088
104PDGFRA0.34732143
105CSNK1G20.32904341
106PRKCB0.31960421
107MOS0.31879471
108ROCK10.29607855
109ERBB20.29265872
110MAPK80.29133712
111PRKCA0.27103219
112RPS6KA20.26825036
113CSNK1A10.26614372
114CAMK1G0.25620432
115CCNB10.25273997
116SRC0.22653867
117CAMK1D0.22410833
118GSK3B0.20332303

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.30602247
2Nicotine addiction_Homo sapiens_hsa050333.06099376
3Synaptic vesicle cycle_Homo sapiens_hsa047213.03687701
4Circadian entrainment_Homo sapiens_hsa047132.76322965
5Long-term potentiation_Homo sapiens_hsa047202.71242662
6Amphetamine addiction_Homo sapiens_hsa050312.67628971
7GABAergic synapse_Homo sapiens_hsa047272.65943830
8Morphine addiction_Homo sapiens_hsa050322.62894194
9Glutamatergic synapse_Homo sapiens_hsa047242.56733531
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45510972
11Dopaminergic synapse_Homo sapiens_hsa047282.27796518
12Insulin secretion_Homo sapiens_hsa049112.15979724
13Salivary secretion_Homo sapiens_hsa049702.14277326
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.13147888
15Cholinergic synapse_Homo sapiens_hsa047252.12571441
16Cocaine addiction_Homo sapiens_hsa050302.12378286
17Aldosterone synthesis and secretion_Homo sapiens_hsa049252.01119726
18Vitamin B6 metabolism_Homo sapiens_hsa007501.97571644
19Gastric acid secretion_Homo sapiens_hsa049711.94433799
20Renin secretion_Homo sapiens_hsa049241.77655034
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76621737
22Nitrogen metabolism_Homo sapiens_hsa009101.76153548
23Oxytocin signaling pathway_Homo sapiens_hsa049211.74338606
24Calcium signaling pathway_Homo sapiens_hsa040201.62345166
25Long-term depression_Homo sapiens_hsa047301.56083874
26GnRH signaling pathway_Homo sapiens_hsa049121.52212068
27Taste transduction_Homo sapiens_hsa047421.51781964
28Serotonergic synapse_Homo sapiens_hsa047261.51563031
29Gap junction_Homo sapiens_hsa045401.43309578
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40162484
31cAMP signaling pathway_Homo sapiens_hsa040241.34244024
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32662235
33Type II diabetes mellitus_Homo sapiens_hsa049301.29414792
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29273363
35Glioma_Homo sapiens_hsa052141.24743753
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.18115819
37Estrogen signaling pathway_Homo sapiens_hsa049151.15308528
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08037194
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03804085
40Melanogenesis_Homo sapiens_hsa049161.03505841
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.01354457
42ErbB signaling pathway_Homo sapiens_hsa040120.98586281
43Collecting duct acid secretion_Homo sapiens_hsa049660.96460932
44Phospholipase D signaling pathway_Homo sapiens_hsa040720.94436433
45Pancreatic secretion_Homo sapiens_hsa049720.91688215
46Oocyte meiosis_Homo sapiens_hsa041140.89033363
47Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87187014
48Thyroid hormone synthesis_Homo sapiens_hsa049180.84841099
49Dorso-ventral axis formation_Homo sapiens_hsa043200.84818285
50Axon guidance_Homo sapiens_hsa043600.83650597
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83431451
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81529630
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81230494
54Cardiac muscle contraction_Homo sapiens_hsa042600.77224539
55Type I diabetes mellitus_Homo sapiens_hsa049400.76763667
56Dilated cardiomyopathy_Homo sapiens_hsa054140.73995260
57Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72823660
58VEGF signaling pathway_Homo sapiens_hsa043700.70913011
59Choline metabolism in cancer_Homo sapiens_hsa052310.70459756
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70176130
61Phototransduction_Homo sapiens_hsa047440.69909917
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.68974799
63Alcoholism_Homo sapiens_hsa050340.68865413
64MAPK signaling pathway_Homo sapiens_hsa040100.67874545
65Non-small cell lung cancer_Homo sapiens_hsa052230.67166009
66Vibrio cholerae infection_Homo sapiens_hsa051100.66911251
67Rap1 signaling pathway_Homo sapiens_hsa040150.66170898
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62525283
69mTOR signaling pathway_Homo sapiens_hsa041500.62420485
70Glucagon signaling pathway_Homo sapiens_hsa049220.62412181
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.58812101
72Endocytosis_Homo sapiens_hsa041440.55695558
73Bile secretion_Homo sapiens_hsa049760.55593913
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.54768075
75Ras signaling pathway_Homo sapiens_hsa040140.54040594
76Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51268667
77Prion diseases_Homo sapiens_hsa050200.50148793
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49736908
79Inositol phosphate metabolism_Homo sapiens_hsa005620.48846918
80Chemokine signaling pathway_Homo sapiens_hsa040620.48764126
81Circadian rhythm_Homo sapiens_hsa047100.47078529
82Endometrial cancer_Homo sapiens_hsa052130.45934248
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45673214
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44895772
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44270841
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42595449
87Arginine biosynthesis_Homo sapiens_hsa002200.42312808
88Arginine and proline metabolism_Homo sapiens_hsa003300.40589543
89Insulin signaling pathway_Homo sapiens_hsa049100.39680806
90Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39540134
91Renal cell carcinoma_Homo sapiens_hsa052110.38360982
92Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38280027
93African trypanosomiasis_Homo sapiens_hsa051430.36796191
94Ovarian steroidogenesis_Homo sapiens_hsa049130.35623261
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34020457
96Platelet activation_Homo sapiens_hsa046110.31409828
97Wnt signaling pathway_Homo sapiens_hsa043100.31060908
98Mineral absorption_Homo sapiens_hsa049780.27516473
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26547740
100Prolactin signaling pathway_Homo sapiens_hsa049170.26538937
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.26366086
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26005056
103Histidine metabolism_Homo sapiens_hsa003400.25995000
104HIF-1 signaling pathway_Homo sapiens_hsa040660.25050125
105Alzheimers disease_Homo sapiens_hsa050100.24716976
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24191229
107AMPK signaling pathway_Homo sapiens_hsa041520.24116313
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24098957
109Fatty acid biosynthesis_Homo sapiens_hsa000610.21989767
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20258050
111Tight junction_Homo sapiens_hsa045300.20183428
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.18781262

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