FBXL18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.52054038
2postsynaptic membrane organization (GO:0001941)6.48370291
3presynaptic membrane assembly (GO:0097105)5.84845743
4presynaptic membrane organization (GO:0097090)5.22995386
5auditory behavior (GO:0031223)5.18335675
6startle response (GO:0001964)4.95266305
7regulation of pigment cell differentiation (GO:0050932)4.59647734
8mechanosensory behavior (GO:0007638)4.53240666
9facial nerve structural organization (GO:0021612)4.17268076
10developmental pigmentation (GO:0048066)4.14387149
11negative regulation of myotube differentiation (GO:0010832)4.01708504
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.98366504
13neuronal action potential propagation (GO:0019227)3.97136977
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.95389191
15fucose catabolic process (GO:0019317)3.89847797
16L-fucose metabolic process (GO:0042354)3.89847797
17L-fucose catabolic process (GO:0042355)3.89847797
18negative regulation of transcription by competitive promoter binding (GO:0010944)3.85695047
19cranial nerve morphogenesis (GO:0021602)3.84578385
20ionotropic glutamate receptor signaling pathway (GO:0035235)3.84212332
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78835749
22neuron cell-cell adhesion (GO:0007158)3.76746945
23cranial nerve structural organization (GO:0021604)3.75972148
24indolalkylamine metabolic process (GO:0006586)3.71231121
25generation of neurons (GO:0048699)3.70604213
26central nervous system projection neuron axonogenesis (GO:0021952)3.69542997
27mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.66940196
28response to auditory stimulus (GO:0010996)3.61271482
29negative regulation of granulocyte differentiation (GO:0030853)3.58846740
30central nervous system neuron axonogenesis (GO:0021955)3.57317896
31negative regulation of telomere maintenance (GO:0032205)3.56106339
32pyrimidine nucleobase catabolic process (GO:0006208)3.51902319
33tongue development (GO:0043586)3.49797100
34protein localization to synapse (GO:0035418)3.48252382
35protein polyglutamylation (GO:0018095)3.43708639
36glutamate receptor signaling pathway (GO:0007215)3.43481006
37reflex (GO:0060004)3.41612896
38righting reflex (GO:0060013)3.40096282
39positive regulation of dendritic spine development (GO:0060999)3.35071382
40central nervous system myelination (GO:0022010)3.35000785
41axon ensheathment in central nervous system (GO:0032291)3.35000785
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.34672848
43kynurenine metabolic process (GO:0070189)3.30549073
44regulation of timing of cell differentiation (GO:0048505)3.28744026
45indole-containing compound catabolic process (GO:0042436)3.27621422
46indolalkylamine catabolic process (GO:0046218)3.27621422
47tryptophan catabolic process (GO:0006569)3.27621422
48regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26275407
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.25316816
50synaptic transmission, glutamatergic (GO:0035249)3.24561768
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.23213174
52cell proliferation in forebrain (GO:0021846)3.22854255
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.22284503
54regulation of hippo signaling (GO:0035330)3.21913452
55regulation of non-canonical Wnt signaling pathway (GO:2000050)3.21755335
56protein complex biogenesis (GO:0070271)3.19492552
57mitochondrial respiratory chain complex I assembly (GO:0032981)3.19391415
58NADH dehydrogenase complex assembly (GO:0010257)3.19391415
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.19391415
60spinal cord association neuron differentiation (GO:0021527)3.16034484
61parturition (GO:0007567)3.15196512
62positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13365696
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13043614
64sympathetic nervous system development (GO:0048485)3.12666616
65synaptic transmission, cholinergic (GO:0007271)3.11550861
66GPI anchor biosynthetic process (GO:0006506)3.08058574
67vocalization behavior (GO:0071625)3.07932226
68water-soluble vitamin biosynthetic process (GO:0042364)3.06063058
69cytochrome complex assembly (GO:0017004)3.04903543
70cell morphogenesis involved in neuron differentiation (GO:0048667)3.02690415
71detection of light stimulus involved in visual perception (GO:0050908)3.02041402
72detection of light stimulus involved in sensory perception (GO:0050962)3.02041402
73indole-containing compound metabolic process (GO:0042430)3.01643719
74positive regulation of synapse assembly (GO:0051965)3.00154628
75regulation of respiratory system process (GO:0044065)3.00044698
76dendritic spine morphogenesis (GO:0060997)2.99000529
77response to pheromone (GO:0019236)2.98964043
78regulation of glutamate receptor signaling pathway (GO:1900449)2.98493172
79mitochondrial respiratory chain complex assembly (GO:0033108)2.98236979
80serotonin metabolic process (GO:0042428)2.98106354
81negative regulation of transcription regulatory region DNA binding (GO:2000678)2.97313546
82primary amino compound metabolic process (GO:1901160)2.95723778
83rRNA catabolic process (GO:0016075)2.94673201
84regulation of mesoderm development (GO:2000380)2.94591574
85mesonephros development (GO:0001823)2.93678659
86specification of organ identity (GO:0010092)2.90151119
87nonmotile primary cilium assembly (GO:0035058)2.89776958
88regulation of respiratory gaseous exchange (GO:0043576)2.89467166
89nucleobase catabolic process (GO:0046113)2.88936454
90gamma-aminobutyric acid transport (GO:0015812)2.87098352
91nephron tubule formation (GO:0072079)2.86948574
92regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.86508038
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.86364528
94positive regulation of dendritic spine morphogenesis (GO:0061003)2.86131995
95C-terminal protein lipidation (GO:0006501)2.85510572
96DNA deamination (GO:0045006)2.85144777
97regulation of action potential (GO:0098900)2.84891762
98G-protein coupled receptor internalization (GO:0002031)2.83428894
99negative regulation of systemic arterial blood pressure (GO:0003085)2.82214112
100neurofilament cytoskeleton organization (GO:0060052)2.81717159
101negative regulation of T cell differentiation in thymus (GO:0033085)2.81696662
102piRNA metabolic process (GO:0034587)2.81529399
103regulation of development, heterochronic (GO:0040034)2.80634788
104neuron-neuron synaptic transmission (GO:0007270)2.79995000
105epithelial cilium movement (GO:0003351)2.79410365
106neurotransmitter-gated ion channel clustering (GO:0072578)2.79196691
107mannosylation (GO:0097502)2.79079565
108tryptophan metabolic process (GO:0006568)2.77960319
109cornea development in camera-type eye (GO:0061303)2.77879950
110sulfation (GO:0051923)2.77832608
111positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.76888946
112lymphoid progenitor cell differentiation (GO:0002320)2.75622456
113regulation of telomere maintenance (GO:0032204)2.74544595
114spinal cord development (GO:0021510)2.74389099
115respiratory chain complex IV assembly (GO:0008535)2.73781262
116myeloid leukocyte mediated immunity (GO:0002444)2.73627019
117positive regulation of fatty acid oxidation (GO:0046321)2.72300144
118protein heterotetramerization (GO:0051290)2.70139886
119GPI anchor metabolic process (GO:0006505)2.68456436
120C-terminal protein amino acid modification (GO:0018410)2.66923322
121positive regulation of neurotransmitter secretion (GO:0001956)2.66454412
122positive regulation of cellular amine metabolic process (GO:0033240)2.66144975
123positive regulation of membrane potential (GO:0045838)2.65674826
124mesenchymal to epithelial transition (GO:0060231)2.65115174
125viral genome replication (GO:0019079)2.65000948
126L-amino acid import (GO:0043092)2.64906100
127behavioral response to ethanol (GO:0048149)2.64832787
128cranial nerve development (GO:0021545)2.63961114
129positive regulation of fatty acid beta-oxidation (GO:0032000)2.63759637
130androgen biosynthetic process (GO:0006702)2.62467371
131long-term memory (GO:0007616)2.61571216
132neuronal action potential (GO:0019228)2.61368899
133adult walking behavior (GO:0007628)2.59151175
134regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58436768
135oxidative demethylation (GO:0070989)2.58284728
136synapse assembly (GO:0007416)2.57197561
137telomere maintenance via semi-conservative replication (GO:0032201)2.56813496
138head development (GO:0060322)2.56602359
139innervation (GO:0060384)2.56116323
140regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55552080
141DNA methylation involved in gamete generation (GO:0043046)2.55341178
142rhodopsin mediated signaling pathway (GO:0016056)2.55246542
143cochlea development (GO:0090102)2.53773948
144regulation of synapse assembly (GO:0051963)2.53768914
145protein-cofactor linkage (GO:0018065)2.53191367
146membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52648044
147regulation of excitatory postsynaptic membrane potential (GO:0060079)2.52279767
148regulation of mitochondrial translation (GO:0070129)2.51295001
149gamma-aminobutyric acid signaling pathway (GO:0007214)2.50728372
150short-term memory (GO:0007614)2.49812647
151cellular ketone body metabolic process (GO:0046950)2.49805643
152membrane depolarization during action potential (GO:0086010)2.49780104
153negative regulation of response to food (GO:0032096)2.49096394
154negative regulation of appetite (GO:0032099)2.49096394
155polyketide metabolic process (GO:0030638)2.48859509
156doxorubicin metabolic process (GO:0044598)2.48859509
157daunorubicin metabolic process (GO:0044597)2.48859509
158positive regulation of action potential (GO:0045760)2.48020335
159positive regulation of gastrulation (GO:2000543)2.47732835
160transmission of nerve impulse (GO:0019226)2.47626237
161DNA integration (GO:0015074)2.47390367
162protein localization to cilium (GO:0061512)2.47205486
163retinal ganglion cell axon guidance (GO:0031290)2.46775609
164regulation of synaptic transmission, GABAergic (GO:0032228)2.46376124
165neurogenesis (GO:0022008)2.45284052
166centriole assembly (GO:0098534)2.44948685
167kidney morphogenesis (GO:0060993)2.44804973
168urogenital system development (GO:0001655)2.44133670
169somite development (GO:0061053)2.43284130
170neuromuscular synaptic transmission (GO:0007274)2.42568053
171regulation of somitogenesis (GO:0014807)2.42430009
172amino acid import (GO:0043090)2.41240743
173regulation of cellular respiration (GO:0043457)2.41189996
174regulation of gene silencing by RNA (GO:0060966)2.40850157
175regulation of posttranscriptional gene silencing (GO:0060147)2.40850157
176regulation of gene silencing by miRNA (GO:0060964)2.40850157
177auditory receptor cell stereocilium organization (GO:0060088)2.39937358
178peptidyl-histidine modification (GO:0018202)2.39752631
179spinal cord motor neuron differentiation (GO:0021522)2.37597187
180negative regulation of cytosolic calcium ion concentration (GO:0051481)2.37581575
181membrane repolarization during action potential (GO:0086011)2.36868838
182chaperone-mediated protein transport (GO:0072321)2.35108165
183regulation of nuclear cell cycle DNA replication (GO:0033262)2.33523902
184DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.33480263
185tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.32787165
186RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.32787165
187axoneme assembly (GO:0035082)2.32350551
188action potential (GO:0001508)2.31684335
189positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.31335221
190regulation of microtubule-based movement (GO:0060632)2.30881864
191glycerophospholipid catabolic process (GO:0046475)2.29091323

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.96007629
2ZNF274_21170338_ChIP-Seq_K562_Hela3.91100386
3GBX2_23144817_ChIP-Seq_PC3_Human3.72946412
4VDR_22108803_ChIP-Seq_LS180_Human3.25499066
5JARID2_20064375_ChIP-Seq_MESCs_Mouse3.25013154
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.82198224
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.54846073
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.46830078
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.45439798
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38217274
11ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29142061
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26867225
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26867225
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.22843563
15BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14876446
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13132716
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.08492865
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.07783550
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.03895361
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03101301
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.00110148
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99700488
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94368344
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92361999
25* IRF1_19129219_ChIP-ChIP_H3396_Human1.91825606
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.91111273
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88915823
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88795100
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.88614947
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.83937009
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83349729
32SUZ12_27294783_Chip-Seq_NPCs_Mouse1.82188203
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.79472494
34IGF1R_20145208_ChIP-Seq_DFB_Human1.78765082
35* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76413220
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.75958608
37* REST_21632747_ChIP-Seq_MESCs_Mouse1.73377007
38RNF2_27304074_Chip-Seq_NSC_Mouse1.71862292
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71402755
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64105013
41MTF2_20144788_ChIP-Seq_MESCs_Mouse1.62569307
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62511814
43TAF15_26573619_Chip-Seq_HEK293_Human1.60691159
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57282564
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.51671145
46POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51320232
47TP53_22573176_ChIP-Seq_HFKS_Human1.50316629
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.49182473
49EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45877522
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45776882
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.44263677
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44052606
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43513140
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42470281
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.41960848
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41886200
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.41876350
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.41201161
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.41201161
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.41201161
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40069807
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.39358594
63DROSHA_22980978_ChIP-Seq_HELA_Human1.37281845
64RUNX1_27457419_Chip-Seq_LIVER_Mouse1.36895992
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.36669472
66* CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35976897
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.35354370
68P53_22387025_ChIP-Seq_ESCs_Mouse1.35292129
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34961673
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.34948881
71P300_18555785_Chip-Seq_ESCs_Mouse1.33666733
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32002364
73EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.30155072
74P300_19829295_ChIP-Seq_ESCs_Human1.29547934
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.28800531
76GATA3_21878914_ChIP-Seq_MCF-7_Human1.28375353
77NMYC_18555785_Chip-Seq_ESCs_Mouse1.27470978
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.27349961
79ERA_21632823_ChIP-Seq_H3396_Human1.25998971
80BCAT_22108803_ChIP-Seq_LS180_Human1.24717972
81NCOR_22424771_ChIP-Seq_293T_Human1.24033758
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23736857
83CBP_20019798_ChIP-Seq_JUKART_Human1.23736857
84SMAD4_21799915_ChIP-Seq_A2780_Human1.23506159
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23144307
86CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22449193
87MYC_18940864_ChIP-ChIP_HL60_Human1.22251103
88RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22048400
89* TAL1_26923725_Chip-Seq_HPCs_Mouse1.20522552
90AR_25329375_ChIP-Seq_VCAP_Human1.20018531
91OCT4_18555785_Chip-Seq_ESCs_Mouse1.19673190
92ESRRB_18555785_Chip-Seq_ESCs_Mouse1.19278308
93* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17638526
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.15799164
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.15291504
96FOXA1_25329375_ChIP-Seq_VCAP_Human1.15179028
97FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15179028
98SMAD1_18555785_Chip-Seq_ESCs_Mouse1.14336672
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.12520570
100IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12370166
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12045962
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.11882474
103KLF4_18555785_Chip-Seq_ESCs_Mouse1.11810297
104* RUNX2_22187159_ChIP-Seq_PCA_Human1.11406961
105TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11371201
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11371201
107AR_21572438_ChIP-Seq_LNCaP_Human1.11204605
108PU1_27457419_Chip-Seq_LIVER_Mouse1.09253297
109TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09068129
110* REST_18959480_ChIP-ChIP_MESCs_Mouse1.08987038
111FUS_26573619_Chip-Seq_HEK293_Human1.08158615
112CTCF_18555785_Chip-Seq_ESCs_Mouse1.08094142
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07899252
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.07644932
115TAF2_19829295_ChIP-Seq_ESCs_Human1.07633933
116HOXB7_26014856_ChIP-Seq_BT474_Human1.07119728
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05192795
118GABP_17652178_ChIP-ChIP_JURKAT_Human1.02841121
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02661739
120EWS_26573619_Chip-Seq_HEK293_Human1.01596656
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01235635
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00657163
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99694681
124TP63_19390658_ChIP-ChIP_HaCaT_Human0.99211808
125AUTS2_25519132_ChIP-Seq_293T-REX_Human0.96593408
126OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96289907
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.96239407
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96007770
129TCF4_22108803_ChIP-Seq_LS180_Human0.95028368
130PIAS1_25552417_ChIP-Seq_VCAP_Human0.93539924
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93073781
132KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92821041
133TDRD3_21172665_ChIP-Seq_MCF-7_Human0.92772892
134FLI1_21867929_ChIP-Seq_TH2_Mouse0.92771191
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.92414486
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.92171064
137STAT3_23295773_ChIP-Seq_U87_Human0.91101730
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.88879674
139TCF4_23295773_ChIP-Seq_U87_Human0.88843332
140ER_23166858_ChIP-Seq_MCF-7_Human0.88593772
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88578925

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005409_darkened_coat_color5.03277640
2MP0003136_yellow_coat_color4.08911565
3MP0001188_hyperpigmentation4.06444069
4MP0006292_abnormal_olfactory_placode4.01866031
5MP0003880_abnormal_central_pattern3.95111236
6MP0009379_abnormal_foot_pigmentation3.45709949
7MP0000015_abnormal_ear_pigmentation2.73593979
8MP0004859_abnormal_synaptic_plasticity2.66345980
9MP0005174_abnormal_tail_pigmentation2.65952063
10MP0000566_synostosis2.56507898
11MP0004381_abnormal_hair_follicle2.50384522
12MP0001968_abnormal_touch/_nociception2.29109035
13MP0000569_abnormal_digit_pigmentation2.27793274
14MP0005423_abnormal_somatic_nervous2.15291906
15MP0003635_abnormal_synaptic_transmissio2.06941381
16MP0008877_abnormal_DNA_methylation2.02638856
17MP0001486_abnormal_startle_reflex1.99671116
18MP0002736_abnormal_nociception_after1.94926219
19MP0005171_absent_coat_pigmentation1.93127536
20MP0001986_abnormal_taste_sensitivity1.92369817
21MP0009745_abnormal_behavioral_response1.92115337
22MP0002102_abnormal_ear_morphology1.91947624
23MP0009046_muscle_twitch1.91038127
24MP0002653_abnormal_ependyma_morphology1.87056127
25MP0008872_abnormal_physiological_respon1.78657911
26MP0000778_abnormal_nervous_system1.78551787
27MP0008260_abnormal_autophagy1.78372156
28MP0004885_abnormal_endolymph1.73506769
29MP0002272_abnormal_nervous_system1.71628723
30MP0005075_abnormal_melanosome_morpholog1.68134027
31MP0003195_calcinosis1.66725113
32MP0002067_abnormal_sensory_capabilities1.62445782
33MP0001502_abnormal_circadian_rhythm1.59524716
34MP0002184_abnormal_innervation1.58819905
35MP0002095_abnormal_skin_pigmentation1.57194871
36MP0002277_abnormal_respiratory_mucosa1.57093536
37MP0002064_seizures1.54233116
38MP0000631_abnormal_neuroendocrine_gland1.51227409
39MP0002572_abnormal_emotion/affect_behav1.50834604
40MP0004142_abnormal_muscle_tone1.49704615
41MP0002638_abnormal_pupillary_reflex1.49197259
42MP0002837_dystrophic_cardiac_calcinosis1.48422413
43MP0010386_abnormal_urinary_bladder1.48396982
44MP0006072_abnormal_retinal_apoptosis1.46445663
45MP0002160_abnormal_reproductive_system1.46351834
46MP0002234_abnormal_pharynx_morphology1.45149669
47MP0004270_analgesia1.44456517
48MP0004043_abnormal_pH_regulation1.44371791
49MP0006276_abnormal_autonomic_nervous1.43249735
50MP0002557_abnormal_social/conspecific_i1.42093080
51MP0002734_abnormal_mechanical_nocicepti1.40653335
52MP0000427_abnormal_hair_cycle1.40097012
53MP0002063_abnormal_learning/memory/cond1.39979893
54MP0003938_abnormal_ear_development1.38278985
55MP0004742_abnormal_vestibular_system1.37716409
56MP0002735_abnormal_chemical_nociception1.34619839
57MP0003011_delayed_dark_adaptation1.33243922
58MP0003879_abnormal_hair_cell1.30873084
59MP0008875_abnormal_xenobiotic_pharmacok1.30801259
60MP0005253_abnormal_eye_physiology1.29504587
61MP0002928_abnormal_bile_duct1.29385733
62MP0005394_taste/olfaction_phenotype1.28345062
63MP0005499_abnormal_olfactory_system1.28345062
64MP0000026_abnormal_inner_ear1.27431268
65MP0001970_abnormal_pain_threshold1.24942266
66MP0003137_abnormal_impulse_conducting1.24511580
67MP0005389_reproductive_system_phenotype1.23208573
68MP0008789_abnormal_olfactory_epithelium1.21980003
69MP0002751_abnormal_autonomic_nervous1.20751774
70MP0003724_increased_susceptibility_to1.18932298
71MP0000955_abnormal_spinal_cord1.17870068
72MP0003121_genomic_imprinting1.16459411
73MP0003283_abnormal_digestive_organ1.16447088
74MP0003646_muscle_fatigue1.16221479
75MP0002249_abnormal_larynx_morphology1.15940534
76MP0002876_abnormal_thyroid_physiology1.15836488
77MP0000049_abnormal_middle_ear1.15057366
78MP0005195_abnormal_posterior_eye1.14929845
79MP0004130_abnormal_muscle_cell1.14467774
80MP0005645_abnormal_hypothalamus_physiol1.13766793
81MP0002938_white_spotting1.11370310
82MP0003119_abnormal_digestive_system1.11245789
83MP0000613_abnormal_salivary_gland1.11169954
84MP0003890_abnormal_embryonic-extraembry1.11149138
85MP0000681_abnormal_thyroid_gland1.08220136
86MP0001963_abnormal_hearing_physiology1.07949462
87MP0002752_abnormal_somatic_nervous1.05343947
88MP0008569_lethality_at_weaning1.01633571
89MP0005084_abnormal_gallbladder_morpholo1.00864372
90MP0001984_abnormal_olfaction0.99807179
91MP0008058_abnormal_DNA_repair0.99416342
92MP0002733_abnormal_thermal_nociception0.99252366
93MP0000372_irregular_coat_pigmentation0.98297929
94MP0001919_abnormal_reproductive_system0.98097750
95MP0000538_abnormal_urinary_bladder0.97838462
96MP0004085_abnormal_heartbeat0.97646823
97MP0002177_abnormal_outer_ear0.97336579
98MP0008961_abnormal_basal_metabolism0.97235435
99MP0002138_abnormal_hepatobiliary_system0.96391752
100MP0008057_abnormal_DNA_replication0.96170131
101MP0003787_abnormal_imprinting0.95333146
102MP0009697_abnormal_copulation0.94756160
103MP0002882_abnormal_neuron_morphology0.92817962
104MP0008995_early_reproductive_senescence0.92173556
105MP0002075_abnormal_coat/hair_pigmentati0.90921233
106MP0003878_abnormal_ear_physiology0.89612939
107MP0005377_hearing/vestibular/ear_phenot0.89612939
108MP0000920_abnormal_myelination0.89007180
109MP0001529_abnormal_vocalization0.88582263
110MP0000230_abnormal_systemic_arterial0.87383151
111MP0000383_abnormal_hair_follicle0.86789292
112MP0001346_abnormal_lacrimal_gland0.85115166
113MP0005646_abnormal_pituitary_gland0.84824467
114MP0001501_abnormal_sleep_pattern0.84747595
115MP0003122_maternal_imprinting0.84148390
116MP0003941_abnormal_skin_development0.83737196
117MP0004133_heterotaxia0.83478386
118MP0001293_anophthalmia0.83437198
119MP0005386_behavior/neurological_phenoty0.82947488
120MP0004924_abnormal_behavior0.82947488
121MP0001186_pigmentation_phenotype0.80320444
122MP0001440_abnormal_grooming_behavior0.79911333
123MP0002066_abnormal_motor_capabilities/c0.75981580
124MP0001485_abnormal_pinna_reflex0.75192636
125MP0005379_endocrine/exocrine_gland_phen0.75144151
126MP0002152_abnormal_brain_morphology0.74443263
127MP0001905_abnormal_dopamine_level0.72813292
128MP0000678_abnormal_parathyroid_gland0.71480393
129MP0005551_abnormal_eye_electrophysiolog0.69253888
130MP0002229_neurodegeneration0.63889595
131MP0000762_abnormal_tongue_morphology0.61667561
132MP0003303_peritoneal_inflammation0.61515988
133MP0000490_abnormal_crypts_of0.61427170
134MP0004145_abnormal_muscle_electrophysio0.61223478
135MP0003718_maternal_effect0.61189034
136MP0004811_abnormal_neuron_physiology0.59714697
137MP0002163_abnormal_gland_morphology0.58815879

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)5.58306805
2Type I transferrin isoform profile (HP:0003642)5.13174121
3Pancreatic cysts (HP:0001737)4.21585843
4Abnormality of midbrain morphology (HP:0002418)4.04505643
5Molar tooth sign on MRI (HP:0002419)4.04505643
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.01822698
7Congenital stationary night blindness (HP:0007642)3.94523046
8Nephronophthisis (HP:0000090)3.54524970
9Focal motor seizures (HP:0011153)3.43582714
10Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.40373085
11Abnormal protein N-linked glycosylation (HP:0012347)3.40373085
12Abnormal protein glycosylation (HP:0012346)3.40373085
13Abnormal glycosylation (HP:0012345)3.40373085
14Type II lissencephaly (HP:0007260)3.35644084
15Chromsome breakage (HP:0040012)3.27624820
16Hyperventilation (HP:0002883)3.12515193
17Abnormality of the axillary hair (HP:0100134)3.12337604
18Abnormality of secondary sexual hair (HP:0009888)3.12337604
19Abnormality of the renal medulla (HP:0100957)3.06214443
20Pendular nystagmus (HP:0012043)3.03650912
21Abnormal sex determination (HP:0012244)3.01440264
22Sex reversal (HP:0012245)3.01440264
23Annular pancreas (HP:0001734)3.00539519
24Abnormality of the renal cortex (HP:0011035)2.98692306
25Chronic hepatic failure (HP:0100626)2.91469177
26Cystic liver disease (HP:0006706)2.91433809
27Abolished electroretinogram (ERG) (HP:0000550)2.91307904
28Medial flaring of the eyebrow (HP:0010747)2.89007858
29Decreased circulating renin level (HP:0003351)2.86367136
30Septo-optic dysplasia (HP:0100842)2.85156365
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.82505987
32Absent/shortened dynein arms (HP:0200106)2.82505987
33Febrile seizures (HP:0002373)2.77604529
34Thyroid-stimulating hormone excess (HP:0002925)2.73511715
35Tubular atrophy (HP:0000092)2.70946723
36Duplicated collecting system (HP:0000081)2.67136325
37Genetic anticipation (HP:0003743)2.64346899
38Congenital, generalized hypertrichosis (HP:0004540)2.62592290
39Sclerocornea (HP:0000647)2.62229881
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.56584199
41Abnormality of alanine metabolism (HP:0010916)2.56584199
42Hyperalaninemia (HP:0003348)2.56584199
43Abnormality of the preputium (HP:0100587)2.55952404
44Nonprogressive disorder (HP:0003680)2.55353426
45Concave nail (HP:0001598)2.54486948
46Meckel diverticulum (HP:0002245)2.53402756
47Gaze-evoked nystagmus (HP:0000640)2.52908002
48Clumsiness (HP:0002312)2.52481723
49Aplasia/Hypoplasia of the uvula (HP:0010293)2.50110899
50Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49894078
51Hypothermia (HP:0002045)2.48776742
52Obstructive sleep apnea (HP:0002870)2.48766163
53Supernumerary spleens (HP:0009799)2.46429865
54Abnormal drinking behavior (HP:0030082)2.45457463
55Polydipsia (HP:0001959)2.45457463
56Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45419405
57Abnormality of the renal collecting system (HP:0004742)2.45414335
58Abnormality of the ileum (HP:0001549)2.45378068
59Lissencephaly (HP:0001339)2.45255946
60Inability to walk (HP:0002540)2.43889129
61Cerebellar dysplasia (HP:0007033)2.42541239
62Aplasia/Hypoplasia of the sacrum (HP:0008517)2.41852247
63Hypoplasia of the pons (HP:0012110)2.37350514
64Patellar aplasia (HP:0006443)2.36688152
65Optic nerve hypoplasia (HP:0000609)2.35983650
66Anencephaly (HP:0002323)2.35441755
67Gait imbalance (HP:0002141)2.34962597
68Horizontal nystagmus (HP:0000666)2.32952723
69Bilateral microphthalmos (HP:0007633)2.32617518
70Aplasia/Hypoplasia of the patella (HP:0006498)2.32517095
71Absent septum pellucidum (HP:0001331)2.31617684
72Ocular albinism (HP:0001107)2.30529537
73Cortical visual impairment (HP:0100704)2.30204024
74Fibular aplasia (HP:0002990)2.29610829
75Abnormality of the pons (HP:0007361)2.29575729
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28054763
77Attenuation of retinal blood vessels (HP:0007843)2.26114941
78Partial agenesis of the corpus callosum (HP:0001338)2.24833871
79Clubbing of toes (HP:0100760)2.22278681
80Severe visual impairment (HP:0001141)2.19860376
81Abnormality of the carotid arteries (HP:0005344)2.17683373
82Congenital primary aphakia (HP:0007707)2.17657139
83Abnormal ciliary motility (HP:0012262)2.17577803
84Fibular hypoplasia (HP:0003038)2.16382437
85Parakeratosis (HP:0001036)2.16055822
86Chorioretinal atrophy (HP:0000533)2.15991663
87Bony spicule pigmentary retinopathy (HP:0007737)2.15708281
88True hermaphroditism (HP:0010459)2.15190682
89Split foot (HP:0001839)2.14870572
90Renal cortical cysts (HP:0000803)2.14430689
91Flat occiput (HP:0005469)2.12495401
92Duplication of thumb phalanx (HP:0009942)2.11391424
93Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.10104455
94Abnormality of the septum pellucidum (HP:0007375)2.09250119
95Chronic obstructive pulmonary disease (HP:0006510)2.08327765
96Obstructive lung disease (HP:0006536)2.08327765
97Congenital hepatic fibrosis (HP:0002612)2.08055637
98Decreased central vision (HP:0007663)2.07983921
99Pachygyria (HP:0001302)2.06933008
100Progressive cerebellar ataxia (HP:0002073)2.06811943
101Broad-based gait (HP:0002136)2.06556859
102Retinal dysplasia (HP:0007973)2.05915496
103Rib fusion (HP:0000902)2.03444449
104Aplasia/Hypoplasia of the tibia (HP:0005772)2.03256552
105Iris hypopigmentation (HP:0007730)2.02726172
106Nephrogenic diabetes insipidus (HP:0009806)2.02369102
107Aplasia/Hypoplasia of the fovea (HP:0008060)2.01946340
108Hypoplasia of the fovea (HP:0007750)2.01946340
109Progressive inability to walk (HP:0002505)2.00816355
110Abnormality of magnesium homeostasis (HP:0004921)1.99796657
111Keratoconus (HP:0000563)1.99758031
112Increased corneal curvature (HP:0100692)1.99758031
113Abnormality of the columella (HP:0009929)1.99287413
114Abnormal respiratory epithelium morphology (HP:0012253)1.98930084
115Abnormal respiratory motile cilium morphology (HP:0005938)1.98930084
116Mitochondrial inheritance (HP:0001427)1.98400990
117White forelock (HP:0002211)1.98307923
118Reticulocytopenia (HP:0001896)1.97462122
119Renal agenesis (HP:0000104)1.97113305
120Overriding aorta (HP:0002623)1.96935161
121Small hand (HP:0200055)1.96760832
122Severe muscular hypotonia (HP:0006829)1.96743972
123Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95978776
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.94056741
125Patchy hypopigmentation of hair (HP:0011365)1.92826353
126Large for gestational age (HP:0001520)1.90606641
127Aplasia/Hypoplasia of the fibula (HP:0006492)1.88990746
128Polyuria (HP:0000103)1.88961530
129Increased CSF lactate (HP:0002490)1.87886610
130Focal seizures (HP:0007359)1.87555007
131Agitation (HP:0000713)1.86673933
132Furrowed tongue (HP:0000221)1.86583091
133Abnormality of the prostate (HP:0008775)1.85922992
1343-Methylglutaconic aciduria (HP:0003535)1.85733547
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82921760
136Triphalangeal thumb (HP:0001199)1.82857144
137Male pseudohermaphroditism (HP:0000037)1.82560275
138Flat cornea (HP:0007720)1.81176395
139Stomatitis (HP:0010280)1.80659646
140Fair hair (HP:0002286)1.80538699
141Abnormal number of erythroid precursors (HP:0012131)1.80236157
142Genital tract atresia (HP:0001827)1.78639573
143Postaxial foot polydactyly (HP:0001830)1.78577115
144Bile duct proliferation (HP:0001408)1.78498557
145Abnormal biliary tract physiology (HP:0012439)1.78498557
146Abnormality of chromosome stability (HP:0003220)1.78393686
147Nephroblastoma (Wilms tumor) (HP:0002667)1.78061351
148Vaginal atresia (HP:0000148)1.77412381
149Protruding tongue (HP:0010808)1.76757639
150Hepatocellular necrosis (HP:0001404)1.76586211
151Birth length less than 3rd percentile (HP:0003561)1.76004900
152Congenital sensorineural hearing impairment (HP:0008527)1.75867222
153Absent thumb (HP:0009777)1.75231515
154Aplasia/Hypoplasia of the spleen (HP:0010451)1.74851709
155Prolonged partial thromboplastin time (HP:0003645)1.74708134
156Renal Fanconi syndrome (HP:0001994)1.71526843
157Optic disc pallor (HP:0000543)1.71507458
158Pancreatic fibrosis (HP:0100732)1.70998819
159Abnormality of DNA repair (HP:0003254)1.70227007
160Cutaneous finger syndactyly (HP:0010554)1.69226111
161Microvesicular hepatic steatosis (HP:0001414)1.67958146
162Acute necrotizing encephalopathy (HP:0006965)1.67804102
163Generalized hypopigmentation of hair (HP:0011358)1.66966213
164Tented upper lip vermilion (HP:0010804)1.66731574
165Hemiparesis (HP:0001269)1.66440014
166Thoracic kyphosis (HP:0002942)1.65889329
167Occipital encephalocele (HP:0002085)1.65879448
168Absent radius (HP:0003974)1.65194110
169Sleep apnea (HP:0010535)1.64949361
170Progressive external ophthalmoplegia (HP:0000590)1.64390226
171Stereotypic behavior (HP:0000733)1.63246111
172Abnormal number of incisors (HP:0011064)1.63130946
173Supernumerary bones of the axial skeleton (HP:0009144)1.61616078
174Dysmetria (HP:0001310)1.61144727
175Abnormal respiratory motile cilium physiology (HP:0012261)1.60528462
176Abnormal rod and cone electroretinograms (HP:0008323)1.60445504
177Gastroesophageal reflux (HP:0002020)1.60340237
178Embryonal renal neoplasm (HP:0011794)1.60062079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK6.81930485
2FRK5.33514538
3CASK4.16727967
4EIF2AK33.91652791
5MKNK23.89957935
6CDK193.49747803
7WNK42.89202031
8MUSK2.69651206
9STK162.58442835
10MKNK12.44508198
11WNK32.26605711
12EIF2AK22.25024149
13TAOK32.24301026
14FES2.24190719
15MAP2K72.11479966
16IRAK22.10042456
17INSRR2.04941665
18TLK12.02735533
19MAP4K22.01558421
20ACVR1B1.95454348
21PRPF4B1.83076869
22CAMKK21.79982299
23SRPK11.69889234
24NUAK11.68470802
25CLK11.59856798
26NLK1.58829764
27IRAK11.54065465
28EPHA41.53247333
29NTRK31.52017060
30ADRBK11.48911760
31DAPK21.45905609
32IRAK41.42785653
33PIK3CA1.41894930
34YES11.39293518
35UHMK11.38092714
36MAPK151.32745378
37NTRK21.32142485
38BLK1.30853351
39MARK11.28992311
40OXSR11.26736140
41MAPK131.25267488
42IRAK31.23957487
43NEK61.18664315
44CSNK1A1L1.17517741
45PAK31.15253351
46CSNK1G31.09071727
47CSNK1G11.02535441
48ADRBK20.96254079
49CAMK10.94169557
50CAMK1D0.93389936
51PRKD20.90517410
52STK380.89462272
53TEC0.89004684
54TGFBR10.88733417
55VRK10.88575444
56BCKDK0.88104369
57SIK20.85081939
58FER0.83665011
59PRKCE0.82154606
60GRK10.82084304
61MAP3K120.81147210
62CSNK1G20.80976648
63ZAK0.79666427
64GRK70.79261346
65PRKCI0.79244329
66RPS6KA60.79193543
67CAMKK10.77825900
68MAP3K40.77301758
69CAMK1G0.75930420
70MAP4K10.70888227
71CHUK0.67815778
72TXK0.67435827
73MAP3K110.67239424
74TNK20.67175838
75PRKCH0.67106737
76RPS6KA50.66847356
77RIPK40.65162831
78SIK30.64446390
79PRKACA0.64404929
80RPS6KA20.61717532
81ERBB20.60829973
82MAP2K60.59242840
83MAPKAPK50.58558685
84CDK70.58427716
85VRK20.57898292
86STK390.57820572
87PRKAA10.57124544
88NME10.56862600
89MAPKAPK30.56509859
90MARK20.56232865
91BRD40.54492623
92TYRO30.53379243
93TAF10.53221848
94CAMK40.52932304
95NEK20.50974920
96PKN10.50471099
97PRKCQ0.49689525
98CDK30.49669599
99PLK40.49595367
100BMPR1B0.49174945
101IKBKB0.48687615
102DYRK1A0.46447232
103CHEK20.45233962
104CAMK2A0.44895349
105DYRK20.43935482
106PRKCZ0.43857960
107PTK2B0.43544519
108CDK50.43512514
109CAMK2B0.42930149
110PRKCA0.42216874
111HIPK20.41801544
112LIMK10.41530166
113STK38L0.40988591
114FGR0.40879418
115MAP2K20.40875336
116DYRK30.40393114
117TAOK20.39851495
118BTK0.39040596
119AURKA0.37274784
120BMPR20.37089361
121MAP2K40.35635094
122CSNK1D0.35107960
123STK110.34888355
124PRKG20.33831967
125PINK10.33661591
126MAP3K10.33655631
127LYN0.32113476
128KIT0.30600522
129PRKCG0.30438880
130HCK0.29262901
131TIE10.28328396
132ATR0.27815181
133PHKG20.27696016
134PHKG10.27696016
135CDC42BPA0.27617970
136MAPK100.23767195
137AKT30.23757826
138PRKG10.23701121
139SGK4940.23014271
140SGK2230.23014271
141SGK20.23011531
142RPS6KB10.22171510
143CSNK1A10.22117524
144WNK10.21639278
145SGK10.20433944
146CAMK2D0.17851850
147EPHB20.17726663
148FYN0.16670990
149PNCK0.16370356
150GSK3B0.15791101

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.69491756
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.06408396
3Fanconi anemia pathway_Homo sapiens_hsa034602.90416343
4DNA replication_Homo sapiens_hsa030302.44565026
5Glutamatergic synapse_Homo sapiens_hsa047242.32147658
6Phototransduction_Homo sapiens_hsa047442.16032944
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.13437860
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.11647708
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10611893
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.10146439
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.03076143
12Homologous recombination_Homo sapiens_hsa034401.98370314
13Selenocompound metabolism_Homo sapiens_hsa004501.96994515
14Parkinsons disease_Homo sapiens_hsa050121.96628229
15Nitrogen metabolism_Homo sapiens_hsa009101.96459934
16Morphine addiction_Homo sapiens_hsa050321.87827930
17Taste transduction_Homo sapiens_hsa047421.82581003
18Cardiac muscle contraction_Homo sapiens_hsa042601.77719952
19Circadian entrainment_Homo sapiens_hsa047131.75184937
20Butanoate metabolism_Homo sapiens_hsa006501.70809030
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.70249321
22Ribosome_Homo sapiens_hsa030101.65410111
23Tryptophan metabolism_Homo sapiens_hsa003801.61554248
24Serotonergic synapse_Homo sapiens_hsa047261.58281934
25Long-term depression_Homo sapiens_hsa047301.58035344
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.54733147
27GABAergic synapse_Homo sapiens_hsa047271.54017630
28Mismatch repair_Homo sapiens_hsa034301.52851605
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.52535804
30Calcium signaling pathway_Homo sapiens_hsa040201.45525359
31Long-term potentiation_Homo sapiens_hsa047201.41798496
32Caffeine metabolism_Homo sapiens_hsa002321.41767318
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41318054
34Alzheimers disease_Homo sapiens_hsa050101.40403268
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.36886415
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36548891
37Olfactory transduction_Homo sapiens_hsa047401.36184167
38Huntingtons disease_Homo sapiens_hsa050161.35016642
39Ether lipid metabolism_Homo sapiens_hsa005651.34753415
40Amphetamine addiction_Homo sapiens_hsa050311.33657356
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.23890538
42Axon guidance_Homo sapiens_hsa043601.23065002
43Cholinergic synapse_Homo sapiens_hsa047251.18155899
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14802117
45Wnt signaling pathway_Homo sapiens_hsa043101.13370717
46Basal cell carcinoma_Homo sapiens_hsa052171.12404375
47Salivary secretion_Homo sapiens_hsa049701.06855798
48N-Glycan biosynthesis_Homo sapiens_hsa005101.06006274
49Sphingolipid metabolism_Homo sapiens_hsa006001.05547528
50Base excision repair_Homo sapiens_hsa034101.04013224
51Insulin secretion_Homo sapiens_hsa049111.02749321
52ABC transporters_Homo sapiens_hsa020101.01779089
53Fatty acid elongation_Homo sapiens_hsa000621.00254161
54GnRH signaling pathway_Homo sapiens_hsa049120.96994989
55Spliceosome_Homo sapiens_hsa030400.94770716
56Retinol metabolism_Homo sapiens_hsa008300.94321152
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.93237363
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92659397
59African trypanosomiasis_Homo sapiens_hsa051430.91324962
60Sulfur relay system_Homo sapiens_hsa041220.91148079
61Chemical carcinogenesis_Homo sapiens_hsa052040.90336441
62Melanogenesis_Homo sapiens_hsa049160.90146771
63Protein export_Homo sapiens_hsa030600.89113494
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87571066
65Peroxisome_Homo sapiens_hsa041460.87431923
66Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85513709
67Synaptic vesicle cycle_Homo sapiens_hsa047210.84528389
68One carbon pool by folate_Homo sapiens_hsa006700.84100145
69Pyrimidine metabolism_Homo sapiens_hsa002400.84016705
70Circadian rhythm_Homo sapiens_hsa047100.82992577
71Renin secretion_Homo sapiens_hsa049240.82509932
72Intestinal immune network for IgA production_Homo sapiens_hsa046720.81552747
73cAMP signaling pathway_Homo sapiens_hsa040240.80741876
74Arachidonic acid metabolism_Homo sapiens_hsa005900.78731502
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78255377
76Other glycan degradation_Homo sapiens_hsa005110.77350114
77Dopaminergic synapse_Homo sapiens_hsa047280.76808552
78Basal transcription factors_Homo sapiens_hsa030220.76510843
79Alcoholism_Homo sapiens_hsa050340.76407264
80RNA polymerase_Homo sapiens_hsa030200.75924452
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75846409
82Cocaine addiction_Homo sapiens_hsa050300.74112274
83Purine metabolism_Homo sapiens_hsa002300.72444325
84Glycerolipid metabolism_Homo sapiens_hsa005610.72430484
85Non-homologous end-joining_Homo sapiens_hsa034500.71474126
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71021597
87Gap junction_Homo sapiens_hsa045400.70958537
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69764743
89Ovarian steroidogenesis_Homo sapiens_hsa049130.68749069
90Linoleic acid metabolism_Homo sapiens_hsa005910.66825039
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.64986399
92Renin-angiotensin system_Homo sapiens_hsa046140.64038906
93Systemic lupus erythematosus_Homo sapiens_hsa053220.63389934
94Gastric acid secretion_Homo sapiens_hsa049710.62494119
95Collecting duct acid secretion_Homo sapiens_hsa049660.61671088
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59930537
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59468625
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.58632867
99Steroid hormone biosynthesis_Homo sapiens_hsa001400.58037287
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57986248
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.57943761
102Thyroid cancer_Homo sapiens_hsa052160.57151641
103Primary immunodeficiency_Homo sapiens_hsa053400.55169316
104alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54318888
105Fat digestion and absorption_Homo sapiens_hsa049750.53740526
106Oxytocin signaling pathway_Homo sapiens_hsa049210.53674985
107Metabolic pathways_Homo sapiens_hsa011000.53352860
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.51921453
109Dorso-ventral axis formation_Homo sapiens_hsa043200.49116856
110Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48032758
111Nucleotide excision repair_Homo sapiens_hsa034200.46113409
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.45906015
113Vitamin digestion and absorption_Homo sapiens_hsa049770.45578530
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.45287828
115Steroid biosynthesis_Homo sapiens_hsa001000.44698926
116Autoimmune thyroid disease_Homo sapiens_hsa053200.44046403
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43569217
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43495510
119Propanoate metabolism_Homo sapiens_hsa006400.42615478
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42568292
121Phospholipase D signaling pathway_Homo sapiens_hsa040720.42377395
122Notch signaling pathway_Homo sapiens_hsa043300.42352586
123Regulation of autophagy_Homo sapiens_hsa041400.42306891
124Asthma_Homo sapiens_hsa053100.41770957
125Allograft rejection_Homo sapiens_hsa053300.41357422
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41335357
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41100054
128Ras signaling pathway_Homo sapiens_hsa040140.39522339
129Oxidative phosphorylation_Homo sapiens_hsa001900.39448341
130Hedgehog signaling pathway_Homo sapiens_hsa043400.38107315
131Sulfur metabolism_Homo sapiens_hsa009200.37414674
132Hippo signaling pathway_Homo sapiens_hsa043900.35934951
133MAPK signaling pathway_Homo sapiens_hsa040100.35284020
134RNA degradation_Homo sapiens_hsa030180.33770636
135Graft-versus-host disease_Homo sapiens_hsa053320.33636176
136ErbB signaling pathway_Homo sapiens_hsa040120.33544271
137Pancreatic secretion_Homo sapiens_hsa049720.33482824
138Choline metabolism in cancer_Homo sapiens_hsa052310.33112650
139Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32261646
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.31222354
141NF-kappa B signaling pathway_Homo sapiens_hsa040640.28835304

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