FBXL19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pre-miRNA processing (GO:0031054)5.32925300
2regulation of mammary gland epithelial cell proliferation (GO:0033599)4.53693712
3layer formation in cerebral cortex (GO:0021819)4.47453671
4regulation of posttranscriptional gene silencing (GO:0060147)4.30531441
5regulation of gene silencing by miRNA (GO:0060964)4.30531441
6regulation of gene silencing by RNA (GO:0060966)4.30531441
7apoptotic process involved in morphogenesis (GO:0060561)3.91253277
8regulation of hippo signaling (GO:0035330)3.90111791
9polarized epithelial cell differentiation (GO:0030859)3.77596943
10heterochromatin organization (GO:0070828)3.75141753
11activation of Rac GTPase activity (GO:0032863)3.71436619
12establishment of apical/basal cell polarity (GO:0035089)3.67239566
13cell migration in hindbrain (GO:0021535)3.66767266
14peptidyl-arginine omega-N-methylation (GO:0035247)3.66244056
15focal adhesion assembly (GO:0048041)3.58165767
16cell-substrate adherens junction assembly (GO:0007045)3.58165767
17negative regulation of histone methylation (GO:0031061)3.57778029
18regulation of early endosome to late endosome transport (GO:2000641)3.56341028
19establishment of monopolar cell polarity (GO:0061162)3.52900422
20establishment or maintenance of monopolar cell polarity (GO:0061339)3.52900422
21semaphorin-plexin signaling pathway (GO:0071526)3.48999423
22negative regulation of erythrocyte differentiation (GO:0045647)3.47119664
23paraxial mesoderm development (GO:0048339)3.46348790
24peptidyl-arginine methylation (GO:0018216)3.45560079
25peptidyl-arginine N-methylation (GO:0035246)3.45560079
26cell-cell junction maintenance (GO:0045217)3.41144060
27protein localization to endosome (GO:0036010)3.40239022
28convergent extension (GO:0060026)3.39626439
29protein retention in ER lumen (GO:0006621)3.36405673
30nuclear pore organization (GO:0006999)3.36054348
31peptidyl-lysine dimethylation (GO:0018027)3.33124648
32maternal placenta development (GO:0001893)3.30141854
33synaptic vesicle docking involved in exocytosis (GO:0016081)3.29040937
34nuclear pore complex assembly (GO:0051292)3.28639680
35histone H2A monoubiquitination (GO:0035518)3.26504555
36protein complex localization (GO:0031503)3.22042268
37proline biosynthetic process (GO:0006561)3.18931600
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17473314
39cytoskeletal anchoring at plasma membrane (GO:0007016)3.17208663
40regulation of translational fidelity (GO:0006450)3.12212665
41positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.10987856
42maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.10197501
43establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.08244674
44spliceosomal tri-snRNP complex assembly (GO:0000244)3.07929549
45intracellular estrogen receptor signaling pathway (GO:0030520)3.06458061
46DNA unwinding involved in DNA replication (GO:0006268)3.03541580
47Golgi transport vesicle coating (GO:0048200)3.02119997
48COPI coating of Golgi vesicle (GO:0048205)3.02119997
49histone arginine methylation (GO:0034969)3.01842713
50DNA replication-dependent nucleosome organization (GO:0034723)3.00422635
51DNA replication-dependent nucleosome assembly (GO:0006335)3.00422635
52planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99967335
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.97076669
54regulation of sister chromatid cohesion (GO:0007063)2.96943002
55histone H4-K12 acetylation (GO:0043983)2.94113734
56protein localization to kinetochore (GO:0034501)2.93437744
57cell-substrate junction assembly (GO:0007044)2.92859803
58regulation of histone H3-K9 methylation (GO:0051570)2.92589522
59hippo signaling (GO:0035329)2.90099781
60chromatin assembly (GO:0031497)2.89804036
613-UTR-mediated mRNA stabilization (GO:0070935)2.89206915
62sister chromatid segregation (GO:0000819)2.88114021
63regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.87477092
64retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.87454687
65regulation of NFAT protein import into nucleus (GO:0051532)2.86990666
66synaptic vesicle maturation (GO:0016188)2.86437739
67RNA stabilization (GO:0043489)2.85398350
68mRNA stabilization (GO:0048255)2.85398350
69NLS-bearing protein import into nucleus (GO:0006607)2.84724584
70glial cell proliferation (GO:0014009)2.84539882
71neural tube development (GO:0021915)2.84385855
72positive regulation of synapse maturation (GO:0090129)2.84177859
73Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83135758
74dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82316816
75regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81356869
76establishment of nucleus localization (GO:0040023)2.79907902
77regulation of translational termination (GO:0006449)2.79379835
78cellular protein complex localization (GO:0034629)2.79279869
79regulation of RNA export from nucleus (GO:0046831)2.79198208
80G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.78474359
81epithelial cell-cell adhesion (GO:0090136)2.75967820
82regulation of nucleobase-containing compound transport (GO:0032239)2.75093661
83locomotory exploration behavior (GO:0035641)2.74582553
84histone H4-K8 acetylation (GO:0043982)2.73952343
85histone H4-K5 acetylation (GO:0043981)2.73952343
86positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73881361
87protein-DNA complex disassembly (GO:0032986)2.72289398
88nucleosome disassembly (GO:0006337)2.72289398
89glucocorticoid receptor signaling pathway (GO:0042921)2.72135183
90mitotic sister chromatid segregation (GO:0000070)2.71680181
91regulation of glucose import in response to insulin stimulus (GO:2001273)2.70197284
92negative regulation of organelle assembly (GO:1902116)2.68902855
93activation of MAPKKK activity (GO:0000185)2.67950224
94trophectodermal cell differentiation (GO:0001829)2.66191958
95positive regulation of RNA splicing (GO:0033120)2.65487723
96apoptotic process involved in development (GO:1902742)2.64568341
97mitotic G1 DNA damage checkpoint (GO:0031571)2.62333904
98dendritic spine morphogenesis (GO:0060997)2.61596556
99regulation of establishment of planar polarity (GO:0090175)2.61486509
100negative regulation of mRNA processing (GO:0050686)2.61348218
101negative regulation of catenin import into nucleus (GO:0035414)2.60687849
102negative regulation of RNA splicing (GO:0033119)2.59732433
103anterior/posterior axis specification, embryo (GO:0008595)2.59699795
104positive regulation of SMAD protein import into nucleus (GO:0060391)2.59685250
105gastrulation with mouth forming second (GO:0001702)2.58283138
106nuclear envelope disassembly (GO:0051081)2.57546725
107membrane disassembly (GO:0030397)2.57546725
108regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57461837
109gene silencing by RNA (GO:0031047)2.56371941
110epithelial cell differentiation involved in prostate gland development (GO:0060742)2.55876723
111dosage compensation (GO:0007549)2.55217560
112embryonic foregut morphogenesis (GO:0048617)2.55187236
113regulation of chromatin binding (GO:0035561)2.54551234
114establishment or maintenance of apical/basal cell polarity (GO:0035088)2.54366098
115establishment or maintenance of bipolar cell polarity (GO:0061245)2.54366098
116adherens junction assembly (GO:0034333)2.54020422
117regulation of ARF GTPase activity (GO:0032312)2.53964282
118nodal signaling pathway (GO:0038092)2.53298867
119negative regulation of cell fate specification (GO:0009996)2.53052787
120mitotic nuclear envelope disassembly (GO:0007077)2.52189057
121embryonic process involved in female pregnancy (GO:0060136)2.52032502
122cellular response to epidermal growth factor stimulus (GO:0071364)2.51877817
123gene silencing (GO:0016458)2.51407742
124mannose metabolic process (GO:0006013)2.51386068
125regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.50537920
126positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.50537920
127negative regulation of mRNA metabolic process (GO:1903312)2.45923533
128histone H4-K16 acetylation (GO:0043984)2.42688214
129DNA duplex unwinding (GO:0032508)2.42277477
130mitotic chromosome condensation (GO:0007076)2.42062881
131cytoplasmic mRNA processing body assembly (GO:0033962)2.41889026
132regulation of DNA damage checkpoint (GO:2000001)2.41412811
133vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.41232900
134embryonic eye morphogenesis (GO:0048048)2.41041538
135negative regulation of microtubule polymerization (GO:0031115)2.40970118
136regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.40562662
137positive regulation of dendrite morphogenesis (GO:0050775)2.40379814
138DNA geometric change (GO:0032392)2.40159352
139negative regulation of histone modification (GO:0031057)2.39629295
140stress fiber assembly (GO:0043149)2.39336224
141ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.38548414
142pentose-phosphate shunt (GO:0006098)2.38498458
143dopamine receptor signaling pathway (GO:0007212)2.37615619
144protein localization to chromosome, centromeric region (GO:0071459)2.37030494
145protein targeting to plasma membrane (GO:0072661)2.36985205
146mitochondrion transport along microtubule (GO:0047497)2.36688357
147establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.36688357
148negative regulation of cell size (GO:0045792)2.36339596
149peptidyl-tyrosine autophosphorylation (GO:0038083)2.36160823
150positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.36076166
151neuromuscular process controlling balance (GO:0050885)2.35436728
152negative regulation of DNA repair (GO:0045738)2.34976066
153cochlea morphogenesis (GO:0090103)2.34123871
154hemidesmosome assembly (GO:0031581)2.33601185
155cell junction maintenance (GO:0034331)2.31862179
156negative regulation of striated muscle cell differentiation (GO:0051154)2.31765876
157sodium ion export (GO:0071436)2.30391815
158protein localization to microtubule (GO:0035372)2.28679224
159modulation by symbiont of host cellular process (GO:0044068)2.28468002
160eye morphogenesis (GO:0048592)2.27860362
161lymph vessel development (GO:0001945)2.27383550
162basement membrane organization (GO:0071711)2.26872012

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.56178169
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.18388234
3ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.02752143
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.94652635
5* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92190787
6* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.84380390
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.58920992
8MYC_22102868_ChIP-Seq_BL_Human2.56548597
9ZFP281_27345836_Chip-Seq_ESCs_Mouse2.52122095
10THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.45725473
11SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44287941
12SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.43166395
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.32944648
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.32606510
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21975456
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.14339489
17* KDM2B_26808549_Chip-Seq_DND41_Human2.08525170
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.08010446
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03347724
20POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.02801868
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.01423202
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.01423202
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.01423202
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.97177939
25KDM2B_26808549_Chip-Seq_K562_Human1.96586338
26SALL1_21062744_ChIP-ChIP_HESCs_Human1.94377144
27* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.85708413
28ZNF263_19887448_ChIP-Seq_K562_Human1.83788754
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.83309815
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78588848
31KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.77138936
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.76777971
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74728171
34NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.74238731
35TCF7_22412390_ChIP-Seq_EML_Mouse1.73620970
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.71113924
37E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68560313
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67449201
39* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.65809470
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.63653689
41ESR1_15608294_ChIP-ChIP_MCF-7_Human1.63469280
42P68_20966046_ChIP-Seq_HELA_Human1.62187496
43* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62184851
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.56463477
45* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.53803230
46* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.51209388
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.50074708
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.49465550
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49282762
50* NANOG_21062744_ChIP-ChIP_HESCs_Human1.49007816
51FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48844349
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48314576
53POU5F1_16518401_ChIP-PET_MESCs_Mouse1.47390231
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.46953872
55CTCF_27219007_Chip-Seq_ERYTHROID_Human1.46668429
56EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46618105
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.46323268
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.45080215
59LXR_22292898_ChIP-Seq_THP-1_Human1.45025860
60* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43365073
61* SA1_27219007_Chip-Seq_ERYTHROID_Human1.42265484
62SMC4_20622854_ChIP-Seq_HELA_Human1.42066077
63ELK3_25401928_ChIP-Seq_HUVEC_Human1.41899730
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40551707
65CREB1_26743006_Chip-Seq_LNCaP_Human1.40251150
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.36720357
67PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35680070
68HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31639213
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.31338634
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.31284952
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30828968
72* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.30654695
73* MYC_18555785_ChIP-Seq_MESCs_Mouse1.30638058
74* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.29861587
75TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.28809218
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27176085
77RACK7_27058665_Chip-Seq_MCF-7_Human1.26460333
78CLOCK_20551151_ChIP-Seq_293T_Human1.25923898
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.25562104
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25215329
81CTCF_27219007_Chip-Seq_Bcells_Human1.24502577
82VDR_21846776_ChIP-Seq_THP-1_Human1.22598857
83FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22138308
84* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21865793
85VDR_24763502_ChIP-Seq_THP-1_Human1.21345720
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21314439
87* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19534352
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.18470354
89EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18366081
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16978328
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.16428534
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15285352
93NCOR1_26117541_ChIP-Seq_K562_Human1.13408715
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.13288381
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13235732
96PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.13184405
97E2F1_21310950_ChIP-Seq_MCF-7_Human1.13064882
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.11202453
99XRN2_22483619_ChIP-Seq_HELA_Human1.10761734
100* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.10331910
101* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10173025
102PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.09993846
103* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.09910456
104ATF3_27146783_Chip-Seq_COLON_Human1.09397651
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09371088
106RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09128927
107HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08938210
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08884734
109* TP53_22127205_ChIP-Seq_IMR90_Human1.08022657
110MAF_26560356_Chip-Seq_TH1_Human1.07961817
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07859368
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07673804
113NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07379938
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.06671621
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06269552
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05818475
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04478894
118RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04028131
119STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03670806
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.03507040
121ISL1_27105846_Chip-Seq_CPCs_Mouse1.01933943
122CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01476492
123UTX_26944678_Chip-Seq_JUKART_Human1.01203162
124MAF_26560356_Chip-Seq_TH2_Human1.01088261
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.00855071
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99934088
127* POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99932824
128MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99340802
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98640047
130MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98624598
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96592784
132DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96078758
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.95817351
134GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95280251
135CHD1_26751641_Chip-Seq_LNCaP_Human0.94872163
136TP53_20018659_ChIP-ChIP_R1E_Mouse0.94178314
137RARA_24833708_ChIP-Seq_LIVER_Mouse0.93788364
138STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92255394
139OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91896505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity2.98595924
2MP0003705_abnormal_hypodermis_morpholog2.95969356
3MP0003123_paternal_imprinting2.91626613
4MP0000537_abnormal_urethra_morphology2.75687689
5MP0002653_abnormal_ependyma_morphology2.69037905
6MP0005076_abnormal_cell_differentiation2.63395454
7MP0003119_abnormal_digestive_system2.32344254
8MP0002877_abnormal_melanocyte_morpholog2.31521044
9MP0010234_abnormal_vibrissa_follicle2.30831668
10MP0003111_abnormal_nucleus_morphology2.21543205
11MP0003121_genomic_imprinting2.20950596
12MP0005409_darkened_coat_color2.19340084
13MP0010352_gastrointestinal_tract_polyps2.17666331
14MP0003283_abnormal_digestive_organ2.11886438
15MP0000566_synostosis2.08698176
16MP0004858_abnormal_nervous_system2.04948680
17MP0003122_maternal_imprinting1.99470161
18MP0000678_abnormal_parathyroid_gland1.97954656
19MP0002084_abnormal_developmental_patter1.97913740
20MP0000569_abnormal_digit_pigmentation1.94506231
21MP0010030_abnormal_orbit_morphology1.94130387
22MP0009053_abnormal_anal_canal1.91493146
23MP0003890_abnormal_embryonic-extraembry1.83064124
24MP0003453_abnormal_keratinocyte_physiol1.81956207
25MP0004957_abnormal_blastocyst_morpholog1.81926031
26MP0001730_embryonic_growth_arrest1.81606786
27MP0005623_abnormal_meninges_morphology1.81467419
28MP0001849_ear_inflammation1.80291139
29MP0004197_abnormal_fetal_growth/weight/1.80147500
30MP0000579_abnormal_nail_morphology1.79694804
31MP0002089_abnormal_postnatal_growth/wei1.79195101
32MP0002085_abnormal_embryonic_tissue1.74554023
33MP0002796_impaired_skin_barrier1.72782632
34MP0005058_abnormal_lysosome_morphology1.67386952
35MP0005451_abnormal_body_composition1.66703238
36MP0003329_amyloid_beta_deposits1.66567391
37MP0003787_abnormal_imprinting1.66555781
38MP0003861_abnormal_nervous_system1.65607845
39MP0001346_abnormal_lacrimal_gland1.64029285
40MP0010094_abnormal_chromosome_stability1.58468041
41MP0000778_abnormal_nervous_system1.58281422
42MP0003077_abnormal_cell_cycle1.57123694
43MP0008877_abnormal_DNA_methylation1.55950526
44MP0001672_abnormal_embryogenesis/_devel1.54564304
45MP0005380_embryogenesis_phenotype1.54564304
46MP0004233_abnormal_muscle_weight1.53936081
47MP0002086_abnormal_extraembryonic_tissu1.52899721
48MP0000350_abnormal_cell_proliferation1.50229241
49MP0005187_abnormal_penis_morphology1.47346825
50MP0004270_analgesia1.46328392
51MP0001697_abnormal_embryo_size1.45598797
52MP0005501_abnormal_skin_physiology1.42908291
53MP0005257_abnormal_intraocular_pressure1.42647558
54MP0003385_abnormal_body_wall1.42622613
55MP0008260_abnormal_autophagy1.39765732
56MP0000534_abnormal_ureter_morphology1.38685079
57MP0003115_abnormal_respiratory_system1.37621440
58MP0001348_abnormal_lacrimal_gland1.36204084
59MP0003984_embryonic_growth_retardation1.34474728
60MP0002088_abnormal_embryonic_growth/wei1.33855526
61MP0000428_abnormal_craniofacial_morphol1.32700992
62MP0003942_abnormal_urinary_system1.30907577
63MP0010307_abnormal_tumor_latency1.29527089
64MP0003091_abnormal_cell_migration1.28874225
65MP0003937_abnormal_limbs/digits/tail_de1.26484322
66MP0004885_abnormal_endolymph1.25291755
67MP0003635_abnormal_synaptic_transmissio1.24432881
68MP0002080_prenatal_lethality1.24184119
69MP0003567_abnormal_fetal_cardiomyocyte1.23495703
70MP0003172_abnormal_lysosome_physiology1.21025287
71MP0003693_abnormal_embryo_hatching1.20153347
72MP0000955_abnormal_spinal_cord1.19220178
73MP0003935_abnormal_craniofacial_develop1.18782328
74MP0004264_abnormal_extraembryonic_tissu1.18295975
75MP0004811_abnormal_neuron_physiology1.18014917
76MP0000003_abnormal_adipose_tissue1.17329733
77MP0002152_abnormal_brain_morphology1.16241492
78MP0009278_abnormal_bone_marrow1.15181928
79MP0001293_anophthalmia1.13461522
80MP0002697_abnormal_eye_size1.10806360
81MP0005666_abnormal_adipose_tissue1.10733560
82MP0009672_abnormal_birth_weight1.10559633
83MP0002063_abnormal_learning/memory/cond1.09673027
84MP0003315_abnormal_perineum_morphology1.08891732
85MP0003755_abnormal_palate_morphology1.08668817
86MP0008961_abnormal_basal_metabolism1.06540985
87MP0004133_heterotaxia1.06453708
88MP0005375_adipose_tissue_phenotype1.04993612
89MP0002254_reproductive_system_inflammat1.04700203
90MP0009703_decreased_birth_body1.04102248
91MP0008770_decreased_survivor_rate1.03809645
92MP0005248_abnormal_Harderian_gland1.03472844
93MP0003634_abnormal_glial_cell1.03449142
94MP0002081_perinatal_lethality1.02045304
95MP0002098_abnormal_vibrissa_morphology1.01941513
96MP0008057_abnormal_DNA_replication1.00731100
97MP0000733_abnormal_muscle_development1.00391078
98MP0002116_abnormal_craniofacial_bone0.97922160
99MP0002092_abnormal_eye_morphology0.97228978
100MP0002111_abnormal_tail_morphology0.96897516
101MP0003303_peritoneal_inflammation0.96059882
102MP0002249_abnormal_larynx_morphology0.95887229
103MP0005621_abnormal_cell_physiology0.95672866
104MP0002925_abnormal_cardiovascular_devel0.92053078
105MP0000858_altered_metastatic_potential0.91556671
106MP0004808_abnormal_hematopoietic_stem0.91451328
107MP0005499_abnormal_olfactory_system0.90895221
108MP0005394_taste/olfaction_phenotype0.90895221
109MP0000762_abnormal_tongue_morphology0.89893196
110MP0000462_abnormal_digestive_system0.89671283
111MP0002060_abnormal_skin_morphology0.89396960
112MP0002396_abnormal_hematopoietic_system0.89127919
113MP0002184_abnormal_innervation0.89122466
114MP0000432_abnormal_head_morphology0.87484384
115MP0008932_abnormal_embryonic_tissue0.87248419
116MP0009780_abnormal_chondrocyte_physiolo0.86106761
117MP0010630_abnormal_cardiac_muscle0.85738278
118MP0002932_abnormal_joint_morphology0.84904526
119MP0004185_abnormal_adipocyte_glucose0.84772152
120MP0003566_abnormal_cell_adhesion0.84638663
121MP0003941_abnormal_skin_development0.83167850
122MP0000467_abnormal_esophagus_morphology0.82723953
123MP0008007_abnormal_cellular_replicative0.81938016
124MP0005423_abnormal_somatic_nervous0.81358429
125MP0002114_abnormal_axial_skeleton0.81139589
126MP0000049_abnormal_middle_ear0.79710926
127MP0000490_abnormal_crypts_of0.79152624
128MP0001915_intracranial_hemorrhage0.78788584
129MP0000681_abnormal_thyroid_gland0.77924603
130MP0002282_abnormal_trachea_morphology0.77557697
131MP0002210_abnormal_sex_determination0.77214919
132MP0004272_abnormal_basement_membrane0.76796623
133MP0001145_abnormal_male_reproductive0.76088194
134MP0008438_abnormal_cutaneous_collagen0.75639124
135MP0002233_abnormal_nose_morphology0.74402429
136MP0003938_abnormal_ear_development0.73847512
137MP0004381_abnormal_hair_follicle0.73782500
138MP0001216_abnormal_epidermal_layer0.72817898

Predicted human phenotypes

RankGene SetZ-score
1Hyperacusis (HP:0010780)3.67712263
2Renal duplication (HP:0000075)3.44428555
3Abnormality of the lower motor neuron (HP:0002366)3.38533826
4Ependymoma (HP:0002888)3.28577407
5Astrocytoma (HP:0009592)3.22460344
6Abnormality of the astrocytes (HP:0100707)3.22460344
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.10879061
8Short 4th metacarpal (HP:0010044)3.10879061
9Insomnia (HP:0100785)3.08926990
10Obstructive sleep apnea (HP:0002870)3.03987694
11Elfin facies (HP:0004428)2.90008292
12Renovascular hypertension (HP:0100817)2.84493442
13Overriding aorta (HP:0002623)2.79932492
14Pointed chin (HP:0000307)2.72179224
15Broad face (HP:0000283)2.68793025
16Long palpebral fissure (HP:0000637)2.62895492
17Amyotrophic lateral sclerosis (HP:0007354)2.62787742
18Shallow orbits (HP:0000586)2.59309809
19Disproportionate tall stature (HP:0001519)2.58110837
20Increased nuchal translucency (HP:0010880)2.50713379
21Heterotopia (HP:0002282)2.47175192
22Abnormality of the 4th metacarpal (HP:0010012)2.44418697
23Broad distal phalanx of finger (HP:0009836)2.39674625
24Asymmetry of the thorax (HP:0001555)2.39089015
25Abnormality of the distal phalanx of the thumb (HP:0009617)2.38822808
26Medulloblastoma (HP:0002885)2.38022796
27Glioma (HP:0009733)2.35910382
28Abnormality of the diencephalon (HP:0010662)2.34759124
29Protrusio acetabuli (HP:0003179)2.29043833
30Distal lower limb amyotrophy (HP:0008944)2.27722636
31Hand muscle atrophy (HP:0009130)2.24631830
32Abnormality of the labia minora (HP:0012880)2.23660150
33Dysmetric saccades (HP:0000641)2.22287478
34Ankyloglossia (HP:0010296)2.21019871
35Flat cornea (HP:0007720)2.19958572
36Lower limb amyotrophy (HP:0007210)2.18141338
37Annular pancreas (HP:0001734)2.17342364
38Cerebral inclusion bodies (HP:0100314)2.16722843
39Neoplasm of the oral cavity (HP:0100649)2.16218118
40Achilles tendon contracture (HP:0001771)2.13790304
41Premature rupture of membranes (HP:0001788)2.13265074
42Selective tooth agenesis (HP:0001592)2.13196896
43Bowel diverticulosis (HP:0005222)2.12559604
44Upper limb amyotrophy (HP:0009129)2.12021693
45Distal upper limb amyotrophy (HP:0007149)2.12021693
46Flat acetabular roof (HP:0003180)2.06493128
47Megalocornea (HP:0000485)2.05621283
48Shawl scrotum (HP:0000049)2.05226954
49Missing ribs (HP:0000921)2.05087511
50Pseudobulbar signs (HP:0002200)2.02051044
51Sacral dimple (HP:0000960)2.02031220
52Neoplasm of striated muscle (HP:0009728)2.00163003
53Aplasia of the phalanges of the hand (HP:0009802)1.99799020
54Aplasia involving bones of the extremities (HP:0009825)1.99799020
55Aplasia involving bones of the upper limbs (HP:0009823)1.99799020
56Stridor (HP:0010307)1.98998900
57Broad thumb (HP:0011304)1.98919615
58Cerebral aneurysm (HP:0004944)1.98874086
59Termporal pattern (HP:0011008)1.98684088
60Insidious onset (HP:0003587)1.98684088
61Abnormality of the thoracic spine (HP:0100711)1.97628672
62Supranuclear gaze palsy (HP:0000605)1.96818052
63Macroorchidism (HP:0000053)1.95469802
64Deep palmar crease (HP:0006191)1.95396822
65Fibroma (HP:0010614)1.95199422
66Colon cancer (HP:0003003)1.94261239
67Thin bony cortex (HP:0002753)1.93087909
68Neurofibrillary tangles (HP:0002185)1.92712233
69Subacute progressive viral hepatitis (HP:0006572)1.91360809
70Thin ribs (HP:0000883)1.90933102
71Truncus arteriosus (HP:0001660)1.90865384
72Apathy (HP:0000741)1.90494729
73Urethral obstruction (HP:0000796)1.90205741
74Neoplasm of the heart (HP:0100544)1.89305311
75Abnormality of the aortic arch (HP:0012303)1.88876997
76Short phalanx of the thumb (HP:0009660)1.88556238
77Fibrous tissue neoplasm (HP:0012316)1.88039152
78Rib fusion (HP:0000902)1.87746216
79Bladder diverticulum (HP:0000015)1.86196704
80Fragile skin (HP:0001030)1.86125689
81Bowel incontinence (HP:0002607)1.85793484
82Mitral regurgitation (HP:0001653)1.82747109
83Facial hemangioma (HP:0000329)1.82514142
84Gastrointestinal carcinoma (HP:0002672)1.81765108
85Malignant gastrointestinal tract tumors (HP:0006749)1.81765108
86Genu recurvatum (HP:0002816)1.81632072
87Hepatoblastoma (HP:0002884)1.81206262
88Abnormality of the phalanges of the hallux (HP:0010057)1.81031075
89Cortical dysplasia (HP:0002539)1.80516608
90Trigonocephaly (HP:0000243)1.78810420
91Turricephaly (HP:0000262)1.78431820
92Abnormality of the Achilles tendon (HP:0005109)1.77940826
93Abnormality of the fingertips (HP:0001211)1.77204110
94Syringomyelia (HP:0003396)1.76626873
95Spinal cord lesions (HP:0100561)1.76626873
96Biconcave vertebral bodies (HP:0004586)1.76398890
97Obsessive-compulsive behavior (HP:0000722)1.76090838
98Precocious puberty (HP:0000826)1.75258181
99Myokymia (HP:0002411)1.75044266
100Arnold-Chiari malformation (HP:0002308)1.74663708
101Abnormal large intestine physiology (HP:0012700)1.74147501
102Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.73993514
103Short 1st metacarpal (HP:0010034)1.73993514
104High anterior hairline (HP:0009890)1.73332569
105Metaphyseal cupping (HP:0003021)1.73070396
106Polygenic inheritance (HP:0010982)1.72488381
107Spina bifida occulta (HP:0003298)1.72132076
108Abnormality of oral frenula (HP:0000190)1.71476010
109Supernumerary ribs (HP:0005815)1.71338730
110Diminished motivation (HP:0000745)1.70623081
111Leiomyosarcoma (HP:0100243)1.70458086
112Uterine leiomyosarcoma (HP:0002891)1.70458086
113Short humerus (HP:0005792)1.70103782
114Bronchomalacia (HP:0002780)1.69872495
115Deviation of the thumb (HP:0009603)1.68551602
116Hypopigmentation of the fundus (HP:0007894)1.68253058
117Partial duplication of thumb phalanx (HP:0009944)1.67995285
118Deviation of the hallux (HP:0010051)1.67120572
119Long eyelashes (HP:0000527)1.67062380
120Premature skin wrinkling (HP:0100678)1.66362225
121Enlarged penis (HP:0000040)1.65700477
122Advanced eruption of teeth (HP:0006288)1.65587904
123Centrally nucleated skeletal muscle fibers (HP:0003687)1.65497164
124Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.64351018
125Hallux valgus (HP:0001822)1.64147833
126Ankle clonus (HP:0011448)1.63671044
127Hyperparathyroidism (HP:0000843)1.63119739
128Proximal placement of thumb (HP:0009623)1.63108686
129Lymphangioma (HP:0100764)1.62993319
130Hypercalcemia (HP:0003072)1.61564930
131Ulnar bowing (HP:0003031)1.61532387
132Germ cell neoplasia (HP:0100728)1.60933354
133Difficulty climbing stairs (HP:0003551)1.60679729
134Rhabdomyosarcoma (HP:0002859)1.60575960
135Partial duplication of the phalanx of hand (HP:0009999)1.60201046
136Bowed forearm bones (HP:0003956)1.60052060
137Bowing of the arm (HP:0006488)1.60052060
138Adenoma sebaceum (HP:0009720)1.59872736
139Angiofibromas (HP:0010615)1.59872736
140Aplasia/Hypoplasia of the sternum (HP:0006714)1.59121342
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.58939625
142Intellectual disability, profound (HP:0002187)1.58939077
143Broad palm (HP:0001169)1.58675290
144Broad phalanges of the hand (HP:0009768)1.58484226
145Abnormal number of incisors (HP:0011064)1.58334047
146Patellar dislocation (HP:0002999)1.57608826
147Aplasia/hypoplasia of the humerus (HP:0006507)1.57033643
148Neuronal loss in central nervous system (HP:0002529)1.56369593
149Atrophic scars (HP:0001075)1.55363350
150Skull defect (HP:0001362)1.55268714
151Intestinal polyp (HP:0005266)1.55118522
152Lower limb asymmetry (HP:0100559)1.54810376
153Hemiparesis (HP:0001269)1.54650149
154Thoracic kyphosis (HP:0002942)1.54376076
155Shoulder girdle muscle weakness (HP:0003547)1.54170036
156Bladder carcinoma (HP:0002862)1.54150329
157Abnormality of the distal phalanges of the toes (HP:0010182)1.53873137
158Vertebral arch anomaly (HP:0008438)1.53095523
159Vertebral compression fractures (HP:0002953)1.52748932
160Mitral valve prolapse (HP:0001634)1.50519076
161Supernumerary nipples (HP:0002558)1.50331587
162Hyperthyroidism (HP:0000836)1.50222620

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.89926838
2CDK123.32383995
3MARK13.08143321
4PRPF4B3.06965220
5LATS22.89950760
6SIK12.89084817
7MAP3K92.86032027
8EEF2K2.82124674
9PKN22.69344044
10TRIB32.65208679
11ICK2.63728949
12MAP3K102.58767435
13TYRO32.36175979
14IRAK32.36055922
15PRKD32.21859496
16CDC72.05097497
17ALK1.88939627
18NEK21.77082474
19PDGFRA1.70606866
20NME21.69084442
21LATS11.64661638
22FGFR41.62916734
23PAK61.60628499
24KSR21.60233065
25RIPK11.59596270
26SIK21.55106443
27SCYL21.54659057
28NEK11.51378817
29TAOK11.51214489
30KSR11.48319231
31BMX1.46091108
32RPS6KB21.30564234
33MAP3K41.28661627
34DDR21.27789626
35MTOR1.26061581
36ERN11.25639813
37MINK11.19678442
38NTRK21.17520071
39DAPK21.13014976
40PTK61.07293574
41TAOK21.06790970
42EPHA21.04932203
43TTK1.02227403
44ARAF1.00372996
45EPHB20.96088181
46PAK40.95791622
47RET0.95172875
48MST1R0.94817880
49BRD40.94631038
50CAMKK10.92241588
51IRAK20.91745819
52NTRK30.91260048
53MAP3K130.90343419
54BRAF0.90207608
55STK380.89212931
56CHEK20.83645414
57PNCK0.83606556
58MAP3K110.83210185
59NTRK10.82768508
60CDK70.82202146
61CHEK10.81340364
62EPHA40.80869137
63MAP2K20.78964124
64MAP2K30.78365297
65PTK20.77630558
66PAK20.75436298
67CDK20.74770753
68FGFR10.74666918
69RPS6KC10.73355947
70RPS6KL10.73355947
71MAP3K10.73088513
72PDPK10.72956588
73MAP3K60.72889754
74CDK40.72814515
75CDK60.72769655
76DYRK20.71333590
77UHMK10.70704844
78STK110.69743292
79DAPK10.67432433
80MAP3K80.67245927
81CDK150.67106055
82PRKD20.65957163
83MARK20.65482433
84CAMK1G0.65455527
85PLK10.65305996
86CSNK1D0.65050040
87PRKCI0.64505760
88KDR0.62579916
89CSNK1E0.62005527
90CDK180.61284829
91CDK11A0.61179668
92PDGFRB0.60526629
93HIPK20.59008519
94PASK0.58818467
95CDK140.58475302
96AKT20.58265874
97ATR0.58165159
98LMTK20.57927059
99ERBB20.57619801
100CDC42BPA0.56153373
101RPS6KA20.54879028
102CDK10.54684306
103MAP3K20.54162856
104CDK50.52503321
105CSNK1G20.52239201
106ATM0.49502638
107RPS6KA60.48338222
108RPS6KA10.48264865
109MET0.47848232
110CSNK1A1L0.46904836
111TSSK60.46896951
112WEE10.46871020
113GSK3B0.46547474
114PRKG20.46393603
115PRKDC0.46127993
116PHKG20.45932975
117PHKG10.45932975
118MAPK100.44994563
119TESK10.44493624
120LIMK10.44300907
121AURKA0.44139502
122ERBB30.43991336
123CAMK1D0.43359197
124TTN0.42547709
125MAPK80.42470229
126MAPK140.41700719
127ILK0.41517526
128BRSK10.40660890
129SGK30.39766609
130FGFR20.38327416
131MAPK110.38109665
132PRKCH0.34902190
133CDK90.32068883
134TESK20.31695170
135PDK10.30941771

Predicted pathways (KEGG)

RankGene SetZ-score
1Hippo signaling pathway_Homo sapiens_hsa043901.93831948
2Basal cell carcinoma_Homo sapiens_hsa052171.91626240
3mRNA surveillance pathway_Homo sapiens_hsa030151.91625701
4mTOR signaling pathway_Homo sapiens_hsa041501.81949225
5Endometrial cancer_Homo sapiens_hsa052131.71959167
6Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.70655875
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70512736
8Hedgehog signaling pathway_Homo sapiens_hsa043401.68274755
9Acute myeloid leukemia_Homo sapiens_hsa052211.66247738
10Oocyte meiosis_Homo sapiens_hsa041141.63776658
11Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.60511418
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58754977
13Colorectal cancer_Homo sapiens_hsa052101.58477697
14Glioma_Homo sapiens_hsa052141.57804466
15RNA transport_Homo sapiens_hsa030131.55847449
16Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.53514631
17Axon guidance_Homo sapiens_hsa043601.46171218
18Chronic myeloid leukemia_Homo sapiens_hsa052201.42216148
19Estrogen signaling pathway_Homo sapiens_hsa049151.40122474
20MicroRNAs in cancer_Homo sapiens_hsa052061.39570842
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.38750232
22Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37847541
23Non-small cell lung cancer_Homo sapiens_hsa052231.37375124
24Prion diseases_Homo sapiens_hsa050201.35118200
25Thyroid hormone signaling pathway_Homo sapiens_hsa049191.32388588
26Notch signaling pathway_Homo sapiens_hsa043301.32167245
27Long-term potentiation_Homo sapiens_hsa047201.31042762
28Dorso-ventral axis formation_Homo sapiens_hsa043201.29327769
29VEGF signaling pathway_Homo sapiens_hsa043701.28955230
30Gap junction_Homo sapiens_hsa045401.28339372
31Other glycan degradation_Homo sapiens_hsa005111.27203085
32Spliceosome_Homo sapiens_hsa030401.25886785
33Cell cycle_Homo sapiens_hsa041101.25514013
34Neurotrophin signaling pathway_Homo sapiens_hsa047221.25359029
35ErbB signaling pathway_Homo sapiens_hsa040121.23999323
36Adherens junction_Homo sapiens_hsa045201.23812715
37Renal cell carcinoma_Homo sapiens_hsa052111.21489413
38Wnt signaling pathway_Homo sapiens_hsa043101.20431554
39Melanogenesis_Homo sapiens_hsa049161.18599261
40Tight junction_Homo sapiens_hsa045301.18298428
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16302961
42Bladder cancer_Homo sapiens_hsa052191.15151104
43Proteoglycans in cancer_Homo sapiens_hsa052051.11988267
44B cell receptor signaling pathway_Homo sapiens_hsa046621.10155706
45Alcoholism_Homo sapiens_hsa050341.09228634
46Vitamin B6 metabolism_Homo sapiens_hsa007501.08297656
47Pentose phosphate pathway_Homo sapiens_hsa000301.07244035
48Thyroid cancer_Homo sapiens_hsa052161.06047714
49GnRH signaling pathway_Homo sapiens_hsa049121.05187470
50Dopaminergic synapse_Homo sapiens_hsa047281.04127128
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.03488119
52Synaptic vesicle cycle_Homo sapiens_hsa047211.02870283
53Small cell lung cancer_Homo sapiens_hsa052221.00396362
54Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00270314
55Type II diabetes mellitus_Homo sapiens_hsa049300.98017574
56Lysine degradation_Homo sapiens_hsa003100.96716359
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95320553
58Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93604322
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93179363
60Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92748549
61Sphingolipid signaling pathway_Homo sapiens_hsa040710.92350411
62TGF-beta signaling pathway_Homo sapiens_hsa043500.91889289
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91790528
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90675499
65Focal adhesion_Homo sapiens_hsa045100.90440101
66Biosynthesis of amino acids_Homo sapiens_hsa012300.90283880
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.90131387
68Oxytocin signaling pathway_Homo sapiens_hsa049210.89702153
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89254393
70Inositol phosphate metabolism_Homo sapiens_hsa005620.89121658
71Olfactory transduction_Homo sapiens_hsa047400.88165294
72Mismatch repair_Homo sapiens_hsa034300.88074083
73Rap1 signaling pathway_Homo sapiens_hsa040150.87405366
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86882907
75Circadian entrainment_Homo sapiens_hsa047130.85505313
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84660239
77Insulin signaling pathway_Homo sapiens_hsa049100.83507288
78Pancreatic cancer_Homo sapiens_hsa052120.83435911
79Choline metabolism in cancer_Homo sapiens_hsa052310.83385387
80Viral carcinogenesis_Homo sapiens_hsa052030.83072546
81Long-term depression_Homo sapiens_hsa047300.82977785
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82889956
83Cholinergic synapse_Homo sapiens_hsa047250.82802433
84Glutamatergic synapse_Homo sapiens_hsa047240.82632315
85HTLV-I infection_Homo sapiens_hsa051660.82503718
86DNA replication_Homo sapiens_hsa030300.81859974
87Pathways in cancer_Homo sapiens_hsa052000.81776228
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80090754
89Amphetamine addiction_Homo sapiens_hsa050310.79235170
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.77744489
91Gastric acid secretion_Homo sapiens_hsa049710.76498799
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76304690
93Cyanoamino acid metabolism_Homo sapiens_hsa004600.75922479
94Apoptosis_Homo sapiens_hsa042100.75063065
95Hepatitis B_Homo sapiens_hsa051610.74612330
96AMPK signaling pathway_Homo sapiens_hsa041520.74610982
97MAPK signaling pathway_Homo sapiens_hsa040100.74274997
98Fructose and mannose metabolism_Homo sapiens_hsa000510.74106818
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73340725
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73271521
101Galactose metabolism_Homo sapiens_hsa000520.72378623
102Amoebiasis_Homo sapiens_hsa051460.72234213
103Melanoma_Homo sapiens_hsa052180.71078759
104Sulfur relay system_Homo sapiens_hsa041220.70000241
105Endocytosis_Homo sapiens_hsa041440.69356478
106Cocaine addiction_Homo sapiens_hsa050300.68651608
107Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68631239
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.67905378
109Salivary secretion_Homo sapiens_hsa049700.66760999
110Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.66058450
111Prostate cancer_Homo sapiens_hsa052150.65266158
112Prolactin signaling pathway_Homo sapiens_hsa049170.64917984
113GABAergic synapse_Homo sapiens_hsa047270.64660222
114Vibrio cholerae infection_Homo sapiens_hsa051100.64211493
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63436620
116Viral myocarditis_Homo sapiens_hsa054160.63245155
117Hepatitis C_Homo sapiens_hsa051600.63178060
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62314747
119p53 signaling pathway_Homo sapiens_hsa041150.61861372
120ECM-receptor interaction_Homo sapiens_hsa045120.61635351
121Shigellosis_Homo sapiens_hsa051310.61104934
122Systemic lupus erythematosus_Homo sapiens_hsa053220.60617205
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60527350
124HIF-1 signaling pathway_Homo sapiens_hsa040660.60326036
125Nicotine addiction_Homo sapiens_hsa050330.60153304
126One carbon pool by folate_Homo sapiens_hsa006700.59769400
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59163609
128Salmonella infection_Homo sapiens_hsa051320.58816407
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56430226

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