FBXL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 12 tandem leucine-rich repeats. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.39147662
2neuron cell-cell adhesion (GO:0007158)5.30545980
3synaptic vesicle exocytosis (GO:0016079)5.11285786
4neuronal action potential propagation (GO:0019227)5.05581203
5vocalization behavior (GO:0071625)4.93894279
6regulation of synaptic vesicle exocytosis (GO:2000300)4.78485633
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.76402857
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.75539483
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.59394172
10protein localization to synapse (GO:0035418)4.57464377
11glutamate secretion (GO:0014047)4.51727142
12presynaptic membrane assembly (GO:0097105)4.50215298
13pyrimidine nucleobase catabolic process (GO:0006208)4.49526971
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43703915
15synaptic vesicle maturation (GO:0016188)4.41997123
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.40243139
17regulation of glutamate receptor signaling pathway (GO:1900449)4.37797159
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.27150850
19postsynaptic membrane organization (GO:0001941)4.24013276
20regulation of synaptic vesicle transport (GO:1902803)4.17769408
21nucleobase catabolic process (GO:0046113)4.13138888
22behavioral response to nicotine (GO:0035095)4.10861454
23presynaptic membrane organization (GO:0097090)4.08249825
24glutamate receptor signaling pathway (GO:0007215)3.95383626
25synaptic transmission, glutamatergic (GO:0035249)3.91975082
26locomotory exploration behavior (GO:0035641)3.88604013
27neuron-neuron synaptic transmission (GO:0007270)3.85872621
28proline transport (GO:0015824)3.84448187
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79785292
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.75218255
31neurotransmitter secretion (GO:0007269)3.74071989
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.66236551
33regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.59244436
34neurotransmitter-gated ion channel clustering (GO:0072578)3.56888157
35regulation of neuronal synaptic plasticity (GO:0048168)3.56869333
36negative regulation of synaptic transmission, GABAergic (GO:0032229)3.55316076
37positive regulation of neurotransmitter secretion (GO:0001956)3.54092335
38epithelial cilium movement (GO:0003351)3.53797490
39negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.53084446
40neuron recognition (GO:0008038)3.50671332
41regulation of excitatory postsynaptic membrane potential (GO:0060079)3.48936417
42positive regulation of membrane potential (GO:0045838)3.46771503
43regulation of vesicle fusion (GO:0031338)3.45425072
44exploration behavior (GO:0035640)3.44451337
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.42859326
46regulation of postsynaptic membrane potential (GO:0060078)3.42574783
47cilium movement (GO:0003341)3.40378750
48regulation of neurotransmitter secretion (GO:0046928)3.39817649
49negative regulation of dendrite morphogenesis (GO:0050774)3.37934375
50cilium or flagellum-dependent cell motility (GO:0001539)3.36271239
51nonmotile primary cilium assembly (GO:0035058)3.35908353
52positive regulation of neurotransmitter transport (GO:0051590)3.35254490
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.34777971
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.33744410
55membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25433404
56detection of calcium ion (GO:0005513)3.24104012
57long-term synaptic potentiation (GO:0060291)3.20494033
58auditory behavior (GO:0031223)3.20338779
59neurotransmitter transport (GO:0006836)3.17521790
60startle response (GO:0001964)3.16800483
61regulation of cilium movement (GO:0003352)3.14840800
62regulation of glutamate secretion (GO:0014048)3.14671500
63transmission of nerve impulse (GO:0019226)3.14590703
64regulation of respiratory system process (GO:0044065)3.14131687
65axoneme assembly (GO:0035082)3.13976893
66synaptic vesicle endocytosis (GO:0048488)3.13110885
67cerebellar Purkinje cell differentiation (GO:0021702)3.11300204
68long-term memory (GO:0007616)3.10055113
69regulation of synaptic plasticity (GO:0048167)3.09368307
70axonal fasciculation (GO:0007413)3.08309764
71regulation of neurotransmitter transport (GO:0051588)3.08257579
72response to histamine (GO:0034776)3.07791739
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05006757
74protein localization to cilium (GO:0061512)3.04480911
75membrane depolarization (GO:0051899)3.02376286
76positive regulation of synapse assembly (GO:0051965)3.02302584
77membrane depolarization during action potential (GO:0086010)3.01947542
78negative regulation of dendrite development (GO:2000171)3.01829320
79G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.01198782
80energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.00374270
81ATP hydrolysis coupled proton transport (GO:0015991)3.00374270
82positive regulation of mitochondrial fission (GO:0090141)2.99889252
83detection of light stimulus involved in sensory perception (GO:0050962)2.98704270
84detection of light stimulus involved in visual perception (GO:0050908)2.98704270
85retinal cone cell development (GO:0046549)2.97389722
86central nervous system projection neuron axonogenesis (GO:0021952)2.97359239
87intraciliary transport (GO:0042073)2.96842858
88membrane hyperpolarization (GO:0060081)2.96467749
89gamma-aminobutyric acid transport (GO:0015812)2.95439920
90dendritic spine morphogenesis (GO:0060997)2.95010716
91synapse assembly (GO:0007416)2.94073190
92innervation (GO:0060384)2.92536633
93protein polyglutamylation (GO:0018095)2.91858841
94regulation of synaptic transmission, GABAergic (GO:0032228)2.91834194
95serotonin metabolic process (GO:0042428)2.91206480
96central nervous system neuron axonogenesis (GO:0021955)2.89926212
97regulation of neurotransmitter levels (GO:0001505)2.89661573
98regulation of synapse structural plasticity (GO:0051823)2.89534671
99neurofilament cytoskeleton organization (GO:0060052)2.89020019
100synaptic vesicle transport (GO:0048489)2.88979713
101establishment of synaptic vesicle localization (GO:0097480)2.88979713
102response to pheromone (GO:0019236)2.88727471
103calcium ion-dependent exocytosis (GO:0017156)2.87247850
104positive regulation of synapse maturation (GO:0090129)2.86616860
105photoreceptor cell maintenance (GO:0045494)2.86399707
106social behavior (GO:0035176)2.84740024
107intraspecies interaction between organisms (GO:0051703)2.84740024
108vesicle transport along microtubule (GO:0047496)2.84396058
109cilium morphogenesis (GO:0060271)2.84310510
110regulation of respiratory gaseous exchange (GO:0043576)2.83898545
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.83637190
112synaptic transmission (GO:0007268)2.83475370
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.82972958
114transferrin transport (GO:0033572)2.82186730
115learning (GO:0007612)2.81924153
116axonemal dynein complex assembly (GO:0070286)2.81911300
117cilium organization (GO:0044782)2.81824611
118neuronal action potential (GO:0019228)2.81059935
119positive regulation of exocytosis (GO:0045921)2.79331545
120adult walking behavior (GO:0007628)2.79217465
121mechanosensory behavior (GO:0007638)2.79206608
122cilium assembly (GO:0042384)2.78899734
123positive regulation of synaptic transmission (GO:0050806)2.77777482
124G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.77757916
125regulation of synaptic transmission (GO:0050804)2.77651050
126layer formation in cerebral cortex (GO:0021819)2.77570012
127neuromuscular process controlling posture (GO:0050884)2.77344820
128retinal ganglion cell axon guidance (GO:0031290)2.75970571
129neural tube formation (GO:0001841)2.75636466
130activation of protein kinase A activity (GO:0034199)2.75046655
131cornea development in camera-type eye (GO:0061303)2.73319925
132glycosphingolipid biosynthetic process (GO:0006688)2.69588996
133behavioral response to ethanol (GO:0048149)2.69409018
134negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69050271
135neuromuscular synaptic transmission (GO:0007274)2.64301456
136behavioral fear response (GO:0001662)2.62189747
137behavioral defense response (GO:0002209)2.62189747
138righting reflex (GO:0060013)2.59392249
139reflex (GO:0060004)2.59081166
140calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.57509990
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.55017774
142regulation of dendritic spine morphogenesis (GO:0061001)2.54126595
143regulation of microtubule-based movement (GO:0060632)2.52403326
144dendrite morphogenesis (GO:0048813)2.51205838
145regulation of feeding behavior (GO:0060259)2.49117856
146positive regulation of dendritic spine morphogenesis (GO:0061003)2.48028323
147synapse organization (GO:0050808)2.45718734
148fear response (GO:0042596)2.45360074
149inner ear receptor stereocilium organization (GO:0060122)2.44806655
150establishment of mitochondrion localization (GO:0051654)2.44335491
151photoreceptor cell development (GO:0042461)2.42590473
152short-term memory (GO:0007614)2.42236211
153adult behavior (GO:0030534)2.41971549
154cerebral cortex radially oriented cell migration (GO:0021799)2.38409195

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.72154963
2GBX2_23144817_ChIP-Seq_PC3_Human4.15512715
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12853842
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.07531845
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89851555
6TAF15_26573619_Chip-Seq_HEK293_Human2.67155345
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.65715773
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64876012
9REST_21632747_ChIP-Seq_MESCs_Mouse2.64747661
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58375324
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53320029
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53320029
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49032411
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.44039937
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39163829
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.35426222
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.33917396
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29232039
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.13229118
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.11641536
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.10262378
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.10168927
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.09829666
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08230993
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.02977520
26RARB_27405468_Chip-Seq_BRAIN_Mouse2.02423653
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96770525
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.94011368
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91097539
30IGF1R_20145208_ChIP-Seq_DFB_Human1.90769675
31P300_19829295_ChIP-Seq_ESCs_Human1.82265682
32IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81950967
33VDR_22108803_ChIP-Seq_LS180_Human1.81799479
34SALL1_21062744_ChIP-ChIP_HESCs_Human1.81319463
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.79425002
36SMAD4_21799915_ChIP-Seq_A2780_Human1.79296325
37DROSHA_22980978_ChIP-Seq_HELA_Human1.73201768
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.70632306
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70595513
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69829569
41EWS_26573619_Chip-Seq_HEK293_Human1.68341661
42FUS_26573619_Chip-Seq_HEK293_Human1.62606530
43AR_21572438_ChIP-Seq_LNCaP_Human1.61474656
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.60767751
45RNF2_27304074_Chip-Seq_NSC_Mouse1.57787585
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56903436
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.56028068
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.48572420
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.47957234
50ZNF274_21170338_ChIP-Seq_K562_Hela1.47766092
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47555630
52CBP_20019798_ChIP-Seq_JUKART_Human1.46533666
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46533666
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45206116
55* PIAS1_25552417_ChIP-Seq_VCAP_Human1.43112072
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.42800969
57NR3C1_23031785_ChIP-Seq_PC12_Mouse1.41015351
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36896520
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35137709
60AR_25329375_ChIP-Seq_VCAP_Human1.34435005
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.31486312
62PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29802503
63* STAT3_23295773_ChIP-Seq_U87_Human1.28096087
64P53_22127205_ChIP-Seq_FIBROBLAST_Human1.23975343
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23198277
66SOX2_21211035_ChIP-Seq_LN229_Gbm1.23110500
67UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20742374
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20618888
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.20088897
70TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18595373
71TP53_22573176_ChIP-Seq_HFKS_Human1.18223983
72TCF4_22108803_ChIP-Seq_LS180_Human1.17441965
73* RUNX2_22187159_ChIP-Seq_PCA_Human1.16990289
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16345939
75JUN_21703547_ChIP-Seq_K562_Human1.16198010
76ER_23166858_ChIP-Seq_MCF-7_Human1.15250115
77CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14632676
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.14464726
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14260449
80TCF4_23295773_ChIP-Seq_U87_Human1.13505323
81KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12056831
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11315135
83FLI1_21867929_ChIP-Seq_TH2_Mouse1.11014898
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.10126077
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09758197
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.09214456
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08849005
88CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08585885
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.06694860
90SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04524353
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.04042882
92RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04022561
93SOX2_19829295_ChIP-Seq_ESCs_Human1.03573943
94NANOG_19829295_ChIP-Seq_ESCs_Human1.03573943
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03030136
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02720859
97TP53_16413492_ChIP-PET_HCT116_Human1.01894101
98TAL1_26923725_Chip-Seq_HPCs_Mouse1.01475148
99KDM2B_26808549_Chip-Seq_REH_Human1.00958789
100YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00251741
101MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99706177
102AR_19668381_ChIP-Seq_PC3_Human0.99663321
103BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99653177
104E2F1_18555785_Chip-Seq_ESCs_Mouse0.99541965
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99450431
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.98929358
107MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98303516
108P53_22387025_ChIP-Seq_ESCs_Mouse0.97913089
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97402655
110SMAD3_21741376_ChIP-Seq_ESCs_Human0.96623676
111NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96533687
112CMYC_18555785_Chip-Seq_ESCs_Mouse0.94923983
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93027606
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91931071
115BCAT_22108803_ChIP-Seq_LS180_Human0.91813977
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91545825
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91545825
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91099380
119FLI1_27457419_Chip-Seq_LIVER_Mouse0.90828227
120AHR_22903824_ChIP-Seq_MCF-7_Human0.90517600
121TP53_18474530_ChIP-ChIP_U2OS_Human0.90503023

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.04324340
2MP0004859_abnormal_synaptic_plasticity4.84822040
3MP0001968_abnormal_touch/_nociception3.82633946
4MP0004270_analgesia3.73812753
5MP0003635_abnormal_synaptic_transmissio3.63078902
6MP0002736_abnormal_nociception_after3.23921458
7MP0009745_abnormal_behavioral_response3.12046233
8MP0002735_abnormal_chemical_nociception2.92204654
9MP0002064_seizures2.89371518
10MP0002063_abnormal_learning/memory/cond2.89083177
11MP0002734_abnormal_mechanical_nocicepti2.83335277
12MP0009046_muscle_twitch2.78335717
13MP0005423_abnormal_somatic_nervous2.68849952
14MP0002572_abnormal_emotion/affect_behav2.68325057
15MP0002272_abnormal_nervous_system2.63114136
16MP0006276_abnormal_autonomic_nervous2.50607435
17MP0001501_abnormal_sleep_pattern2.50061928
18MP0002733_abnormal_thermal_nociception2.47153614
19MP0002102_abnormal_ear_morphology2.35116824
20MP0001486_abnormal_startle_reflex2.34159382
21MP0010386_abnormal_urinary_bladder2.28853668
22MP0001970_abnormal_pain_threshold2.28796583
23MP0008877_abnormal_DNA_methylation2.20121832
24MP0002067_abnormal_sensory_capabilities2.12168240
25MP0002822_catalepsy2.07240063
26MP0001440_abnormal_grooming_behavior2.06802960
27MP0009780_abnormal_chondrocyte_physiolo2.05188188
28MP0002184_abnormal_innervation1.85149243
29MP0005646_abnormal_pituitary_gland1.83719805
30MP0001984_abnormal_olfaction1.81995193
31MP0001188_hyperpigmentation1.81392703
32MP0001986_abnormal_taste_sensitivity1.75969117
33MP0002557_abnormal_social/conspecific_i1.70070552
34MP0000778_abnormal_nervous_system1.68008421
35MP0001529_abnormal_vocalization1.66757750
36MP0005386_behavior/neurological_phenoty1.59018382
37MP0004924_abnormal_behavior1.59018382
38MP0002653_abnormal_ependyma_morphology1.58476804
39MP0001905_abnormal_dopamine_level1.53990626
40MP0003879_abnormal_hair_cell1.52658779
41MP0004811_abnormal_neuron_physiology1.49657489
42MP0005645_abnormal_hypothalamus_physiol1.49613004
43MP0008569_lethality_at_weaning1.47921121
44MP0003329_amyloid_beta_deposits1.46170579
45MP0003121_genomic_imprinting1.45811314
46MP0003787_abnormal_imprinting1.43850733
47MP0004858_abnormal_nervous_system1.42981625
48MP0004133_heterotaxia1.41887818
49MP0002909_abnormal_adrenal_gland1.39437374
50MP0000955_abnormal_spinal_cord1.39259359
51MP0004142_abnormal_muscle_tone1.37030800
52MP0002882_abnormal_neuron_morphology1.36642875
53MP0002638_abnormal_pupillary_reflex1.30448042
54MP0002066_abnormal_motor_capabilities/c1.29015564
55MP0003122_maternal_imprinting1.27913084
56MP0008789_abnormal_olfactory_epithelium1.26667779
57MP0004147_increased_porphyrin_level1.25942184
58MP0004742_abnormal_vestibular_system1.24204448
59MP0001502_abnormal_circadian_rhythm1.21452191
60MP0002837_dystrophic_cardiac_calcinosis1.20483601
61MP0003195_calcinosis1.16284568
62MP0003136_yellow_coat_color1.15086560
63MP0002234_abnormal_pharynx_morphology1.11269910
64MP0000427_abnormal_hair_cycle1.10604339
65MP0003183_abnormal_peptide_metabolism1.09558803
66MP0005379_endocrine/exocrine_gland_phen1.09107412
67MP0003633_abnormal_nervous_system1.05569169
68MP0005171_absent_coat_pigmentation1.03898780
69MP0002928_abnormal_bile_duct1.03333392
70MP0005187_abnormal_penis_morphology1.03223908
71MP0003890_abnormal_embryonic-extraembry1.02197411
72MP0000013_abnormal_adipose_tissue1.01699753
73MP0002160_abnormal_reproductive_system0.99084715
74MP0002229_neurodegeneration0.96606189
75MP0001664_abnormal_digestion0.95495150
76MP0006072_abnormal_retinal_apoptosis0.95348492
77MP0000631_abnormal_neuroendocrine_gland0.94189983
78MP0001963_abnormal_hearing_physiology0.91850827
79MP0003631_nervous_system_phenotype0.91821661
80MP0005195_abnormal_posterior_eye0.90897218
81MP0002152_abnormal_brain_morphology0.90625016
82MP0002876_abnormal_thyroid_physiology0.89981510
83MP0006292_abnormal_olfactory_placode0.89701661
84MP0002938_white_spotting0.87466662
85MP0005535_abnormal_body_temperature0.86009224
86MP0002752_abnormal_somatic_nervous0.85504320
87MP0002163_abnormal_gland_morphology0.85142530
88MP0004145_abnormal_muscle_electrophysio0.85033394
89MP0002751_abnormal_autonomic_nervous0.84861427
90MP0005551_abnormal_eye_electrophysiolog0.84815236
91MP0008875_abnormal_xenobiotic_pharmacok0.82694175
92MP0003698_abnormal_male_reproductive0.82580890
93MP0001485_abnormal_pinna_reflex0.79120448
94MP0000751_myopathy0.78498621
95MP0002069_abnormal_eating/drinking_beha0.78446265
96MP0004885_abnormal_endolymph0.77734543
97MP0003634_abnormal_glial_cell0.77575481
98MP0003119_abnormal_digestive_system0.76274766
99MP0005499_abnormal_olfactory_system0.75074870
100MP0005394_taste/olfaction_phenotype0.75074870
101MP0003937_abnormal_limbs/digits/tail_de0.74837130
102MP0004043_abnormal_pH_regulation0.74152616
103MP0003861_abnormal_nervous_system0.73827459
104MP0000049_abnormal_middle_ear0.73179965
105MP0003646_muscle_fatigue0.72411565
106MP0004085_abnormal_heartbeat0.71816811
107MP0002693_abnormal_pancreas_physiology0.71050578
108MP0000026_abnormal_inner_ear0.70897808
109MP0003283_abnormal_digestive_organ0.69787760
110MP0008872_abnormal_physiological_respon0.69177020
111MP0008874_decreased_physiological_sensi0.68005454
112MP0004215_abnormal_myocardial_fiber0.67409364
113MP0005409_darkened_coat_color0.67172225
114MP0000920_abnormal_myelination0.65670011
115MP0001177_atelectasis0.63157497
116MP0003632_abnormal_nervous_system0.62412438
117MP0000538_abnormal_urinary_bladder0.61731174
118MP0000372_irregular_coat_pigmentation0.57876739
119MP0001943_abnormal_respiration0.55955957
120MP0000015_abnormal_ear_pigmentation0.55755911
121MP0000604_amyloidosis0.52781722
122MP0001270_distended_abdomen0.50534880
123MP0005253_abnormal_eye_physiology0.48828333
124MP0000569_abnormal_digit_pigmentation0.48591520
125MP0009379_abnormal_foot_pigmentation0.47813079

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.41872587
2Myokymia (HP:0002411)5.70797588
3Focal seizures (HP:0007359)5.26742680
4Atonic seizures (HP:0010819)5.20642233
5Epileptic encephalopathy (HP:0200134)4.95910715
6Visual hallucinations (HP:0002367)4.75603613
7Febrile seizures (HP:0002373)4.72879443
8Absence seizures (HP:0002121)4.07626747
9Dialeptic seizures (HP:0011146)3.97589059
10Pancreatic cysts (HP:0001737)3.93616910
11Progressive cerebellar ataxia (HP:0002073)3.85344416
12True hermaphroditism (HP:0010459)3.82048180
13Pancreatic fibrosis (HP:0100732)3.78300644
14Generalized tonic-clonic seizures (HP:0002069)3.70764949
15Abnormality of midbrain morphology (HP:0002418)3.70272545
16Molar tooth sign on MRI (HP:0002419)3.70272545
17Hyperventilation (HP:0002883)3.54779532
18Broad-based gait (HP:0002136)3.50307671
19Progressive inability to walk (HP:0002505)3.40846650
20Nephronophthisis (HP:0000090)3.40177497
21Hypothermia (HP:0002045)3.32194937
22Chronic hepatic failure (HP:0100626)3.15250859
23Amblyopia (HP:0000646)3.07073413
24Action tremor (HP:0002345)3.01825282
25Limb dystonia (HP:0002451)2.92575184
26Supranuclear gaze palsy (HP:0000605)2.90011255
27Abnormality of the renal medulla (HP:0100957)2.89973548
28Anxiety (HP:0000739)2.80054897
29Drooling (HP:0002307)2.79131743
30Excessive salivation (HP:0003781)2.79131743
31Cystic liver disease (HP:0006706)2.76228628
32Gaze-evoked nystagmus (HP:0000640)2.76043705
33Type II lissencephaly (HP:0007260)2.74479883
34Abnormal respiratory motile cilium morphology (HP:0005938)2.72568367
35Abnormal respiratory epithelium morphology (HP:0012253)2.72568367
36Depression (HP:0000716)2.70482818
37Inability to walk (HP:0002540)2.68570563
38Truncal ataxia (HP:0002078)2.64298497
39Poor eye contact (HP:0000817)2.63977211
40Absent speech (HP:0001344)2.59266329
41Poor coordination (HP:0002370)2.58784043
42Protruding tongue (HP:0010808)2.58042444
43Pheochromocytoma (HP:0002666)2.55494643
44Gait imbalance (HP:0002141)2.54243108
45Abnormal hair whorl (HP:0010721)2.53978080
46Abnormality of the renal cortex (HP:0011035)2.49163916
47Neuroendocrine neoplasm (HP:0100634)2.49006684
48Congenital stationary night blindness (HP:0007642)2.47534793
49Ankle clonus (HP:0011448)2.46121173
50Lissencephaly (HP:0001339)2.45024466
51Abnormal drinking behavior (HP:0030082)2.44444678
52Polydipsia (HP:0001959)2.44444678
53Termporal pattern (HP:0011008)2.44345096
54Insidious onset (HP:0003587)2.44345096
55Abnormal eating behavior (HP:0100738)2.44222140
56Failure to thrive in infancy (HP:0001531)2.43351943
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.41233824
58Abnormal respiratory motile cilium physiology (HP:0012261)2.41170296
59Epileptiform EEG discharges (HP:0011182)2.40421190
60Medial flaring of the eyebrow (HP:0010747)2.40008977
61Hemiparesis (HP:0001269)2.39961094
62Impaired vibration sensation in the lower limbs (HP:0002166)2.39662640
63Acute necrotizing encephalopathy (HP:0006965)2.39042799
64Agitation (HP:0000713)2.37643838
65Diplopia (HP:0000651)2.36752041
66Abnormality of binocular vision (HP:0011514)2.36752041
67Polyphagia (HP:0002591)2.34761745
68Aplasia/Hypoplasia of the tongue (HP:0010295)2.32814229
69Dysmetria (HP:0001310)2.32627217
70Occipital encephalocele (HP:0002085)2.32198453
71Retinal dysplasia (HP:0007973)2.31897854
72Hyperthyroidism (HP:0000836)2.27526680
73Sclerocornea (HP:0000647)2.27490103
74Abnormal social behavior (HP:0012433)2.24896868
75Impaired social interactions (HP:0000735)2.24896868
76Abnormal mitochondria in muscle tissue (HP:0008316)2.23771699
77EEG with generalized epileptiform discharges (HP:0011198)2.22036796
78Congenital primary aphakia (HP:0007707)2.22032232
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.21208823
80Tubulointerstitial nephritis (HP:0001970)2.20455267
81Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20330175
82Delusions (HP:0000746)2.20266682
83Neurofibrillary tangles (HP:0002185)2.18199896
84Abnormality of salivation (HP:0100755)2.16768378
85Progressive macrocephaly (HP:0004481)2.16369742
86Urinary bladder sphincter dysfunction (HP:0002839)2.15636265
87Nephrogenic diabetes insipidus (HP:0009806)2.14081652
88Tubular atrophy (HP:0000092)2.14071654
89Fetal akinesia sequence (HP:0001989)2.13893889
90Mitochondrial inheritance (HP:0001427)2.13276328
91Postaxial hand polydactyly (HP:0001162)2.13207535
92Blue irides (HP:0000635)2.10601971
93Mutism (HP:0002300)2.10265850
94Decreased circulating renin level (HP:0003351)2.09779318
95Congenital hepatic fibrosis (HP:0002612)2.09503338
96Attenuation of retinal blood vessels (HP:0007843)2.09230846
97Dysdiadochokinesis (HP:0002075)2.08784513
98Postaxial foot polydactyly (HP:0001830)2.07204925
99Ulnar claw (HP:0001178)2.07041345
100Cerebral inclusion bodies (HP:0100314)2.06213255
101Psychosis (HP:0000709)2.04856159
102Aplasia/Hypoplasia of the lens (HP:0008063)2.04698999
103Pachygyria (HP:0001302)2.04642011
104Anencephaly (HP:0002323)2.03673699
105Cerebellar dysplasia (HP:0007033)2.03517450
106Hypsarrhythmia (HP:0002521)2.01967391
107Bony spicule pigmentary retinopathy (HP:0007737)2.01946796
108Abnormality of the labia minora (HP:0012880)2.01786461
109Specific learning disability (HP:0001328)2.01317100
110Bradykinesia (HP:0002067)2.00878373
111Genital tract atresia (HP:0001827)1.99629867
112Absent/shortened dynein arms (HP:0200106)1.98441871
113Dynein arm defect of respiratory motile cilia (HP:0012255)1.98441871
114Aplasia/Hypoplasia of the tibia (HP:0005772)1.97710391
115Short foot (HP:0001773)1.97386679
116Spastic gait (HP:0002064)1.96617583
117Rhinitis (HP:0012384)1.95889291
118Narrow forehead (HP:0000341)1.95071272
119Poor suck (HP:0002033)1.94893719
120Exotropia (HP:0000577)1.93004900
121Vaginal atresia (HP:0000148)1.92053173
122Hydroureter (HP:0000072)1.90840491
123Esotropia (HP:0000565)1.90144088
124Tubulointerstitial abnormality (HP:0001969)1.89088748
125Akinesia (HP:0002304)1.89014318
126Broad foot (HP:0001769)1.88771857
127Dyskinesia (HP:0100660)1.88273437
128Hypoventilation (HP:0002791)1.88210238
129Impaired smooth pursuit (HP:0007772)1.88150189
130Sensory axonal neuropathy (HP:0003390)1.87639135
131Abnormality of calcium-phosphate metabolism (HP:0100530)1.86151779
132Generalized hypopigmentation of hair (HP:0011358)1.84271571
133Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.83851779
134Abnormality of alanine metabolism (HP:0010916)1.83851779
135Hyperalaninemia (HP:0003348)1.83851779
136Intestinal atresia (HP:0011100)1.83769740
137Scanning speech (HP:0002168)1.83407030
138Neuronal loss in central nervous system (HP:0002529)1.83109704
139Postural tremor (HP:0002174)1.81083747
140Gait ataxia (HP:0002066)1.80009181
141Widely spaced teeth (HP:0000687)1.78930241
142Genetic anticipation (HP:0003743)1.78846762
143Abnormality of the corticospinal tract (HP:0002492)1.78624730
144Oligodactyly (hands) (HP:0001180)1.77162274
145Methylmalonic acidemia (HP:0002912)1.76543768
146Abnormal ciliary motility (HP:0012262)1.75771146
147Papilledema (HP:0001085)1.75536757
148Renal cortical cysts (HP:0000803)1.75300015
149Decreased testicular size (HP:0008734)1.75014366
150Furrowed tongue (HP:0000221)1.74435676
151Astigmatism (HP:0000483)1.73532907
152Preaxial hand polydactyly (HP:0001177)1.73065350
153Left ventricular hypertrophy (HP:0001712)1.72889329
154Retinitis pigmentosa (HP:0000510)1.72746844
155Stereotypic behavior (HP:0000733)1.71839079

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.79449543
2CASK4.46772959
3NTRK33.98388828
4EPHA43.43499883
5MAP3K123.19279243
6MAP3K43.10689615
7MAP2K73.09417135
8MAP3K92.76035721
9MAP4K22.73042830
10RIPK42.68755565
11WNK32.45414137
12TRIM282.37259362
13MINK12.29966161
14DAPK22.25863927
15GRK52.20334828
16MARK12.15528135
17CDK192.05217325
18PINK11.97445894
19NTRK11.93651127
20MAP2K41.87904478
21PLK21.75923422
22MAPK131.68667128
23DAPK11.58116720
24NTRK21.57841328
25ARAF1.57449888
26TNIK1.56748100
27INSRR1.56030669
28BMPR21.55992666
29KSR21.54438986
30PRPF4B1.53376864
31PAK61.49579936
32MAP3K21.37734593
33CDK51.36600761
34ACVR1B1.33122545
35CSNK1A1L1.32294100
36GRK11.27603195
37CSNK1G31.23004971
38CAMKK21.22296035
39UHMK11.21723332
40NUAK11.20430633
41PNCK1.17963288
42OXSR11.17394485
43CSNK1G11.16838629
44FES1.15400116
45CAMK2A1.13426591
46PRKD31.12791227
47BMPR1B1.06530859
48PRKCG1.04768513
49MAPKAPK51.00670620
50ZAK0.99469878
51CAMK2B0.99416941
52SIK20.94303477
53KSR10.94206305
54GRK70.91103843
55CCNB10.90794042
56SIK30.88891348
57PRKCE0.88335560
58ADRBK20.87988180
59NME10.87836579
60BRAF0.87297075
61MKNK20.83259349
62CAMKK10.82382537
63MUSK0.82158674
64AKT30.82007490
65CDK140.81901091
66MAP3K130.81497369
67CDK180.78392250
68TNK20.78384047
69PTK2B0.77818353
70STK380.77662477
71SGK2230.76650725
72SGK4940.76650725
73ADRBK10.76237554
74BCKDK0.73480448
75CDK150.72637520
76MAP3K10.69777364
77STK38L0.69149255
78PKN10.65984688
79CAMK2D0.65083852
80FGR0.65010138
81CDK11A0.63731510
82PHKG10.62130775
83PHKG20.62130775
84DYRK1A0.62058333
85CAMK40.61893074
86CAMK10.61431833
87FER0.60347907
88RET0.60160042
89TLK10.58517054
90CSNK1G20.58342414
91SGK20.58274739
92MAPK150.57645018
93BCR0.57404257
94STK110.56227691
95PRKCZ0.55929118
96MAP3K60.55822868
97CDK80.53766463
98TIE10.53121322
99PAK30.52531206
100CAMK1G0.52434132
101RPS6KA20.51645530
102EPHA30.50439347
103FGFR20.49833589
104HIPK20.49220605
105DAPK30.49184756
106MARK20.47993370
107PDPK10.46832913
108CSNK1A10.46073865
109CSNK1D0.45730305
110CDC42BPA0.44486317
111MAP2K10.44139617
112SGK10.43895374
113PRKAA10.42874476
114LATS10.42206745
115WNK10.41798568
116TAOK30.41302321
117LIMK10.39531870
118CAMK2G0.39326624
119ERBB20.39287390
120IRAK20.38434656
121PRKACB0.37846063
122PRKACA0.37425027
123RAF10.37358439
124PRKG10.35507675
125CAMK1D0.35122953
126WNK40.34650694
127DYRK20.33274347
128STK390.32925672
129PLK40.32590645
130TGFBR10.32054425
131PDK10.31817765
132LMTK20.31769358
133PRKCA0.31413554
134ERBB30.31151634
135MOS0.31131922
136PRKCH0.31095535
137CSNK1E0.29205188
138RPS6KA30.28280014

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.71535336
2Synaptic vesicle cycle_Homo sapiens_hsa047213.55959499
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70700082
4Olfactory transduction_Homo sapiens_hsa047402.62840500
5Collecting duct acid secretion_Homo sapiens_hsa049662.62254397
6Circadian entrainment_Homo sapiens_hsa047132.45880710
7Morphine addiction_Homo sapiens_hsa050322.45184537
8GABAergic synapse_Homo sapiens_hsa047272.43810879
9Long-term potentiation_Homo sapiens_hsa047202.40878786
10Taste transduction_Homo sapiens_hsa047422.38369794
11Amphetamine addiction_Homo sapiens_hsa050312.37075985
12Glutamatergic synapse_Homo sapiens_hsa047242.33673059
13Insulin secretion_Homo sapiens_hsa049112.22372009
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19406008
15Dopaminergic synapse_Homo sapiens_hsa047282.18905104
16Serotonergic synapse_Homo sapiens_hsa047262.07266873
17Oxidative phosphorylation_Homo sapiens_hsa001901.97554977
18Salivary secretion_Homo sapiens_hsa049701.95587450
19Butanoate metabolism_Homo sapiens_hsa006501.94968123
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.90494806
21Vibrio cholerae infection_Homo sapiens_hsa051101.86161532
22Long-term depression_Homo sapiens_hsa047301.76177953
23Cholinergic synapse_Homo sapiens_hsa047251.75696312
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.74347039
25Cocaine addiction_Homo sapiens_hsa050301.74154208
26Renin secretion_Homo sapiens_hsa049241.66210791
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.62412552
28Gastric acid secretion_Homo sapiens_hsa049711.49096361
29Alzheimers disease_Homo sapiens_hsa050101.46723526
30Parkinsons disease_Homo sapiens_hsa050121.46622972
31Calcium signaling pathway_Homo sapiens_hsa040201.46306379
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45267701
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.43220473
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37417406
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35952364
36Linoleic acid metabolism_Homo sapiens_hsa005911.35068218
37Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.31766104
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.31284176
39Nitrogen metabolism_Homo sapiens_hsa009101.31070421
40Oxytocin signaling pathway_Homo sapiens_hsa049211.30194232
41Cardiac muscle contraction_Homo sapiens_hsa042601.26783218
42GnRH signaling pathway_Homo sapiens_hsa049121.25316686
43Gap junction_Homo sapiens_hsa045401.24114150
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19521808
45Phototransduction_Homo sapiens_hsa047441.16336258
46Type II diabetes mellitus_Homo sapiens_hsa049301.12583629
47Propanoate metabolism_Homo sapiens_hsa006401.09586131
48cAMP signaling pathway_Homo sapiens_hsa040241.06422249
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01992634
50Basal transcription factors_Homo sapiens_hsa030221.01508865
51Huntingtons disease_Homo sapiens_hsa050161.01494408
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00642342
53ABC transporters_Homo sapiens_hsa020100.99760470
54Steroid biosynthesis_Homo sapiens_hsa001000.98064661
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.97527332
56Axon guidance_Homo sapiens_hsa043600.97453061
57Tryptophan metabolism_Homo sapiens_hsa003800.93816920
58Estrogen signaling pathway_Homo sapiens_hsa049150.92386931
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.91752565
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91402167
61Melanogenesis_Homo sapiens_hsa049160.91169608
62Rheumatoid arthritis_Homo sapiens_hsa053230.90156312
63ErbB signaling pathway_Homo sapiens_hsa040120.86921752
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85532513
65Type I diabetes mellitus_Homo sapiens_hsa049400.85472471
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.85199188
67Pancreatic secretion_Homo sapiens_hsa049720.84135852
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84105490
69Glioma_Homo sapiens_hsa052140.83482410
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83288539
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80144519
72Selenocompound metabolism_Homo sapiens_hsa004500.77013486
73Hedgehog signaling pathway_Homo sapiens_hsa043400.75048254
74Dorso-ventral axis formation_Homo sapiens_hsa043200.72976271
75beta-Alanine metabolism_Homo sapiens_hsa004100.72680550
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.72244430
77Caffeine metabolism_Homo sapiens_hsa002320.69879663
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68983686
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.68686244
80Phagosome_Homo sapiens_hsa041450.68259950
81Oocyte meiosis_Homo sapiens_hsa041140.67437711
82Alcoholism_Homo sapiens_hsa050340.65813299
83Peroxisome_Homo sapiens_hsa041460.65646546
84MAPK signaling pathway_Homo sapiens_hsa040100.63787017
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62905136
86Hippo signaling pathway_Homo sapiens_hsa043900.62565934
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60900208
88Fanconi anemia pathway_Homo sapiens_hsa034600.60810524
89Chemical carcinogenesis_Homo sapiens_hsa052040.60247911
90Histidine metabolism_Homo sapiens_hsa003400.60027430
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59848600
92Choline metabolism in cancer_Homo sapiens_hsa052310.59085259
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.58838247
94Ras signaling pathway_Homo sapiens_hsa040140.58760549
95Thyroid hormone synthesis_Homo sapiens_hsa049180.58026986
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57646583
97Protein export_Homo sapiens_hsa030600.57393178
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.55914501
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.54007144
100Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52850057
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52531121
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52296750
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50444236
104RNA degradation_Homo sapiens_hsa030180.49816234
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49364957
106Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46487717
107Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46449496
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46078969
109Fatty acid biosynthesis_Homo sapiens_hsa000610.45812430
110Circadian rhythm_Homo sapiens_hsa047100.45006286
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44241741
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.42931067
113Sphingolipid metabolism_Homo sapiens_hsa006000.42652961
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.42552358
115RNA polymerase_Homo sapiens_hsa030200.42170454
116Regulation of autophagy_Homo sapiens_hsa041400.42063363
117Retinol metabolism_Homo sapiens_hsa008300.40747687
118Inositol phosphate metabolism_Homo sapiens_hsa005620.38948998
119Dilated cardiomyopathy_Homo sapiens_hsa054140.38871364
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38387324
121Basal cell carcinoma_Homo sapiens_hsa052170.37081862
122VEGF signaling pathway_Homo sapiens_hsa043700.36365375
123Metabolic pathways_Homo sapiens_hsa011000.36248361
124Tight junction_Homo sapiens_hsa045300.36114597
125Wnt signaling pathway_Homo sapiens_hsa043100.35361842
126Glucagon signaling pathway_Homo sapiens_hsa049220.35320739
127Ether lipid metabolism_Homo sapiens_hsa005650.34302653
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34105998
129Rap1 signaling pathway_Homo sapiens_hsa040150.33757599
130African trypanosomiasis_Homo sapiens_hsa051430.33231818
131Ovarian steroidogenesis_Homo sapiens_hsa049130.33171440
132Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33034114
133Endocytosis_Homo sapiens_hsa041440.30593097
134Melanoma_Homo sapiens_hsa052180.29612535
135Prion diseases_Homo sapiens_hsa050200.28858622
136Prolactin signaling pathway_Homo sapiens_hsa049170.28590720
137Insulin signaling pathway_Homo sapiens_hsa049100.28320340
138Mineral absorption_Homo sapiens_hsa049780.25718458

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