FBXL20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.35828527
2biotin metabolic process (GO:0006768)4.54663324
3vitamin transmembrane transport (GO:0035461)4.54614784
4mannose metabolic process (GO:0006013)4.51341778
5fucose catabolic process (GO:0019317)4.13951120
6L-fucose metabolic process (GO:0042354)4.13951120
7L-fucose catabolic process (GO:0042355)4.13951120
8positive regulation of histone deacetylation (GO:0031065)4.08092499
9response to pheromone (GO:0019236)4.00299496
10neural tube formation (GO:0001841)3.99990742
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73232551
12CDP-diacylglycerol metabolic process (GO:0046341)3.61006040
13intestinal epithelial cell development (GO:0060576)3.59554680
14pre-miRNA processing (GO:0031054)3.50015404
15serine family amino acid catabolic process (GO:0009071)3.49017099
16pyrimidine nucleobase catabolic process (GO:0006208)3.40965199
17indolalkylamine metabolic process (GO:0006586)3.39706920
18gamma-aminobutyric acid transport (GO:0015812)3.27672746
19autophagic vacuole assembly (GO:0000045)3.26547573
20regulation of cholesterol homeostasis (GO:2000188)3.25559423
21lung-associated mesenchyme development (GO:0060484)3.21739897
22NLS-bearing protein import into nucleus (GO:0006607)3.21307488
23CDP-diacylglycerol biosynthetic process (GO:0016024)3.20567508
24protein K11-linked deubiquitination (GO:0035871)3.19974268
25startle response (GO:0001964)3.18532900
26maintenance of protein location in nucleus (GO:0051457)3.17463898
27presynaptic membrane assembly (GO:0097105)3.15774334
28regulation of clathrin-mediated endocytosis (GO:2000369)3.14674207
29positive regulation of protein deacetylation (GO:0090312)3.14654387
30tryptophan metabolic process (GO:0006568)3.13021224
31serotonin metabolic process (GO:0042428)3.11787526
32primary amino compound metabolic process (GO:1901160)3.10216597
33histone H4-K16 acetylation (GO:0043984)3.08169952
34histone H4-K8 acetylation (GO:0043982)3.05750939
35histone H4-K5 acetylation (GO:0043981)3.05750939
36pantothenate metabolic process (GO:0015939)3.05206632
37epithelial cilium movement (GO:0003351)3.04852888
38tryptophan catabolic process (GO:0006569)3.04195095
39indole-containing compound catabolic process (GO:0042436)3.04195095
40indolalkylamine catabolic process (GO:0046218)3.04195095
41detection of light stimulus involved in sensory perception (GO:0050962)2.98755764
42detection of light stimulus involved in visual perception (GO:0050908)2.98755764
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.98564765
44phosphatidylethanolamine metabolic process (GO:0046337)2.96938285
45detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.95980165
46indole-containing compound metabolic process (GO:0042430)2.95226314
47nucleobase catabolic process (GO:0046113)2.94714670
48piRNA metabolic process (GO:0034587)2.93249909
49histone H3-K4 methylation (GO:0051568)2.93092022
50neuronal action potential (GO:0019228)2.92493562
51phosphatidylethanolamine biosynthetic process (GO:0006646)2.92271674
52somite development (GO:0061053)2.92058223
53epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92024720
54cAMP catabolic process (GO:0006198)2.91994906
55negative regulation of cell size (GO:0045792)2.91659351
56histone H3-K36 demethylation (GO:0070544)2.91401099
57sulfation (GO:0051923)2.91303696
58reflex (GO:0060004)2.89967640
59nonmotile primary cilium assembly (GO:0035058)2.89626464
60kynurenine metabolic process (GO:0070189)2.87606607
61sulfur amino acid catabolic process (GO:0000098)2.85020845
62negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84159811
63stress granule assembly (GO:0034063)2.84015494
64regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.82295680
65kidney morphogenesis (GO:0060993)2.81289912
66polyketide metabolic process (GO:0030638)2.79851543
67doxorubicin metabolic process (GO:0044598)2.79851543
68daunorubicin metabolic process (GO:0044597)2.79851543
69postsynaptic membrane organization (GO:0001941)2.79743727
70spinal cord motor neuron differentiation (GO:0021522)2.78552687
71regulation of mitotic spindle organization (GO:0060236)2.78026546
72dendritic spine morphogenesis (GO:0060997)2.77755900
73axoneme assembly (GO:0035082)2.77632308
74negative regulation of macroautophagy (GO:0016242)2.77587148
75regulation of G0 to G1 transition (GO:0070316)2.77469165
76presynaptic membrane organization (GO:0097090)2.76764367
77regulation of histone H3-K27 methylation (GO:0061085)2.73887294
78activated T cell proliferation (GO:0050798)2.73659252
79negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.73526122
80receptor recycling (GO:0001881)2.73330323
81adaptation of signaling pathway (GO:0023058)2.72754450
82regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.72481123
83DNA methylation involved in gamete generation (GO:0043046)2.70929008
84limb bud formation (GO:0060174)2.69343320
85behavioral response to ethanol (GO:0048149)2.68625344
86regulation of spindle organization (GO:0090224)2.67454079
87cornea development in camera-type eye (GO:0061303)2.66767023
88cyclic nucleotide catabolic process (GO:0009214)2.66439468
89cofactor transport (GO:0051181)2.66008366
90negative regulation of translation, ncRNA-mediated (GO:0040033)2.65227282
91regulation of translation, ncRNA-mediated (GO:0045974)2.65227282
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65227282
93cilium or flagellum-dependent cell motility (GO:0001539)2.64925494
94regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63527097
95regulation of hippo signaling (GO:0035330)2.62461378
96positive regulation of fatty acid beta-oxidation (GO:0032000)2.61295185
97cilium movement (GO:0003341)2.61261527
98transmission of nerve impulse (GO:0019226)2.60740613
99regulation of action potential (GO:0098900)2.60240232
100protein polyglutamylation (GO:0018095)2.60127774
101synapse assembly (GO:0007416)2.59268100
102membrane depolarization during action potential (GO:0086010)2.58937765
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58934467
104platelet dense granule organization (GO:0060155)2.56475261
105regulation of apoptotic cell clearance (GO:2000425)2.56003506
106negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.54901943
107histone H3-K4 trimethylation (GO:0080182)2.53370875
108synaptic transmission, cholinergic (GO:0007271)2.53259607
109protein localization to cilium (GO:0061512)2.52926370
110cytoplasmic mRNA processing body assembly (GO:0033962)2.52851196
111cilium organization (GO:0044782)2.52608047
112neuron cell-cell adhesion (GO:0007158)2.51809607
113regulation of translation in response to stress (GO:0043555)2.51758790
114proline transport (GO:0015824)2.50521398
115cerebellar Purkinje cell differentiation (GO:0021702)2.50498496
116macroautophagy (GO:0016236)2.50349632
117cellular ketone body metabolic process (GO:0046950)2.50127448
118histone H2A monoubiquitination (GO:0035518)2.50073845
119regulation of ARF protein signal transduction (GO:0032012)2.50044306
120glycine metabolic process (GO:0006544)2.48663503
121embryonic epithelial tube formation (GO:0001838)2.48663193
122DNA deamination (GO:0045006)2.48586274
123establishment of protein localization to Golgi (GO:0072600)2.48351260
124positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.48162632
125regulation of fatty acid beta-oxidation (GO:0031998)2.47896891
126modified amino acid transport (GO:0072337)2.47845339
127cilium assembly (GO:0042384)2.46929089
128negative regulation of synaptic transmission, GABAergic (GO:0032229)2.46354307
129positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.45978662
130interkinetic nuclear migration (GO:0022027)2.44819991
131purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.44305579
1323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.44305579
133sodium ion export (GO:0071436)2.44010311
134cellular modified amino acid catabolic process (GO:0042219)2.42661316
135negative regulation of fibroblast apoptotic process (GO:2000270)2.41645209
136negative regulation of transcription regulatory region DNA binding (GO:2000678)2.41043058
137labyrinthine layer development (GO:0060711)2.40365346
138regulation of complement activation (GO:0030449)2.40250187
139retinal cone cell development (GO:0046549)2.39370458
140appendage development (GO:0048736)2.38805558
141limb development (GO:0060173)2.38805558
142retinal ganglion cell axon guidance (GO:0031290)2.37780459
143alanine transport (GO:0032328)2.37406120
144regulation of protein activation cascade (GO:2000257)2.35793204
145prostate gland growth (GO:0060736)2.35740452
146head development (GO:0060322)2.35411093
147negative regulation of telomere maintenance (GO:0032205)2.35179908
148peristalsis (GO:0030432)2.35168210
149glutamate receptor signaling pathway (GO:0007215)2.33935367
150fatty acid transmembrane transport (GO:1902001)2.33925944
151protein import into peroxisome matrix (GO:0016558)2.33925502
152positive regulation of CREB transcription factor activity (GO:0032793)2.33723081
153positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.33372126
154cellular response to sterol (GO:0036315)2.32935316
155cell differentiation in spinal cord (GO:0021515)2.32354634
156positive regulation of oligodendrocyte differentiation (GO:0048714)2.32053840
157sympathetic nervous system development (GO:0048485)2.31779247
158preassembly of GPI anchor in ER membrane (GO:0016254)2.31349460
159regulation of telomere maintenance via telomerase (GO:0032210)2.31242683
160negative regulation of systemic arterial blood pressure (GO:0003085)2.30828769
161cilium morphogenesis (GO:0060271)2.30562854
162regulation of calcium ion-dependent exocytosis (GO:0017158)2.29658630
163complement activation, alternative pathway (GO:0006957)2.29064340
164carnitine shuttle (GO:0006853)2.28845754
165folic acid transport (GO:0015884)2.28662162
166positive regulation of cholesterol efflux (GO:0010875)2.28594602
167fructose metabolic process (GO:0006000)2.28560770
168regulation of neurotransmitter uptake (GO:0051580)2.28405333
169protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.28227781
170histone H3-K9 demethylation (GO:0033169)2.26538190
171hormone catabolic process (GO:0042447)2.26464472
172thyroid hormone metabolic process (GO:0042403)2.26261142
173positive regulation of fatty acid transport (GO:2000193)2.25470634
174peptidyl-threonine dephosphorylation (GO:0035970)2.24844916
175epoxygenase P450 pathway (GO:0019373)2.22390523
176negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.22165237
177regulation of histone deacetylation (GO:0031063)2.21986948
178regulation of RNA export from nucleus (GO:0046831)2.21953317
179negative regulation of histone methylation (GO:0031061)2.19713522
180alpha-linolenic acid metabolic process (GO:0036109)2.18896608
181trophectodermal cell differentiation (GO:0001829)2.17503531
182homocysteine metabolic process (GO:0050667)2.17233186
183monoubiquitinated protein deubiquitination (GO:0035520)2.16541501
184regulation of glucose import in response to insulin stimulus (GO:2001273)2.16479866
185seminiferous tubule development (GO:0072520)2.16241703
186negative regulation of TOR signaling (GO:0032007)2.16189457
187embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15265660
188cellular response to cholesterol (GO:0071397)2.14476291
189hippo signaling (GO:0035329)2.13727518
190apoptotic cell clearance (GO:0043277)2.12762381
191positive regulation of macroautophagy (GO:0016239)2.11925828
192regulation of protein deacetylation (GO:0090311)2.11145798
193valine metabolic process (GO:0006573)2.09013076
194triglyceride biosynthetic process (GO:0019432)2.07330005
195insulin-like growth factor receptor signaling pathway (GO:0048009)2.05813829
196negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.05806402
197histone lysine methylation (GO:0034968)2.05789711

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.54122187
2EZH2_22144423_ChIP-Seq_EOC_Human3.48523671
3GBX2_23144817_ChIP-Seq_PC3_Human3.17521136
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77355359
5SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.71566286
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69922507
7VDR_22108803_ChIP-Seq_LS180_Human2.65116298
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.59950210
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.59950210
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.59950210
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.55723471
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.54263447
13NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.45678785
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.44822057
15IGF1R_20145208_ChIP-Seq_DFB_Human2.44069845
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.37083599
17* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29976140
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.29911278
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.29224226
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.27758961
21MYC_22102868_ChIP-Seq_BL_Human2.25546349
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23025848
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18285054
24TAF15_26573619_Chip-Seq_HEK293_Human2.18037895
25TCF7_22412390_ChIP-Seq_EML_Mouse2.17444481
26PPARA_22158963_ChIP-Seq_LIVER_Mouse2.12091969
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.07921111
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.06193753
29KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.00609428
30KDM2B_26808549_Chip-Seq_DND41_Human1.98206666
31ER_23166858_ChIP-Seq_MCF-7_Human1.92192888
32FUS_26573619_Chip-Seq_HEK293_Human1.91400678
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.90835919
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.90508594
35KDM2B_26808549_Chip-Seq_K562_Human1.90256165
36P300_19829295_ChIP-Seq_ESCs_Human1.90041447
37ZNF263_19887448_ChIP-Seq_K562_Human1.87350705
38AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87222369
39* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84893989
40FOXO3_23340844_ChIP-Seq_DLD1_Human1.83729998
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80364122
42NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.78919247
43CLOCK_20551151_ChIP-Seq_293T_Human1.77580529
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.75596734
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74403569
46EWS_26573619_Chip-Seq_HEK293_Human1.74254813
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73360734
48SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.71604746
49HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71584561
50* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.71204548
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70355546
52SMAD4_21799915_ChIP-Seq_A2780_Human1.69652885
53FLI1_27457419_Chip-Seq_LIVER_Mouse1.69158871
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.67239966
55REST_21632747_ChIP-Seq_MESCs_Mouse1.66158934
56TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.65234843
57* STAT3_23295773_ChIP-Seq_U87_Human1.64242325
58FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.62311875
59GATA1_22025678_ChIP-Seq_K562_Human1.62211718
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59862450
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59862450
62AR_21572438_ChIP-Seq_LNCaP_Human1.59849576
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.59315313
64* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.58443703
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.57415894
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57203190
67TCF4_23295773_ChIP-Seq_U87_Human1.57131084
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.55945761
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54260696
70AR_25329375_ChIP-Seq_VCAP_Human1.53173654
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.52452819
72NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.52157827
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.51907516
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51244092
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51068125
76BCAT_22108803_ChIP-Seq_LS180_Human1.50382265
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50301286
78NCOR1_26117541_ChIP-Seq_K562_Human1.48918937
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48557620
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48435599
81SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46709214
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.45021257
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.41793291
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.40828560
85RUNX1_27514584_Chip-Seq_MCF-7_Human1.40738831
86ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39999684
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39730120
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39666454
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39613916
90RNF2_27304074_Chip-Seq_NSC_Mouse1.37503899
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.37340726
92FOXA2_19822575_ChIP-Seq_HepG2_Human1.36948606
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36676088
94CBP_20019798_ChIP-Seq_JUKART_Human1.35758925
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35758925
96BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35460370
97SMAD3_21741376_ChIP-Seq_EPCs_Human1.35181217
98PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34374375
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34307807
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34228714
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33966918
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32979284
103IRF1_19129219_ChIP-ChIP_H3396_Human1.32427941
104NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.32184330
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31811121
106TCF3_18692474_ChIP-Seq_MESCs_Mouse1.31594951
107RACK7_27058665_Chip-Seq_MCF-7_Human1.31462765
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.31199340
109TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30552764
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.30415038
111ESR1_21235772_ChIP-Seq_MCF-7_Human1.29593743
112PRDM14_20953172_ChIP-Seq_ESCs_Human1.29591575
113* CREB1_26743006_Chip-Seq_LNCaP_Human1.26957641
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.25852701
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.25731467
116SCL_19346495_ChIP-Seq_HPC-7_Human1.25669409
117* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.25552233
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25114244
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24768904
120FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.24596804
121RUNX2_22187159_ChIP-Seq_PCA_Human1.24370911
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23010133
123BP1_19119308_ChIP-ChIP_Hs578T_Human1.22523175
124DROSHA_22980978_ChIP-Seq_HELA_Human1.22103561
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21104944
126* FOXM1_23109430_ChIP-Seq_U2OS_Human1.20602178
127TCF4_22108803_ChIP-Seq_LS180_Human1.20091083
128SMC4_20622854_ChIP-Seq_HELA_Human1.18126663
129JARID2_20064375_ChIP-Seq_MESCs_Mouse1.18049654
130CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17176005
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16605796
132TP53_22573176_ChIP-Seq_HFKS_Human1.16568921
133TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16352853
134* TP53_16413492_ChIP-PET_HCT116_Human1.15915606
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15765395
136SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15574800
137ARNT_22903824_ChIP-Seq_MCF-7_Human1.15461402
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.15115742
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15014873
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13916344
141PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13759827
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13343081
143* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.12871512
144* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12820855
145TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12731858
146ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12259712
147NANOG_19829295_ChIP-Seq_ESCs_Human1.11874563
148SOX2_19829295_ChIP-Seq_ESCs_Human1.11874563
149SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11515904
150EZH2_27304074_Chip-Seq_ESCs_Mouse1.11422257
151NANOG_18555785_Chip-Seq_ESCs_Mouse1.11179344
152PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10968450
153SOX2_21211035_ChIP-Seq_LN229_Gbm1.10794548
154KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10460107
155KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10211257
156* SALL1_21062744_ChIP-ChIP_HESCs_Human1.10161685
157SMAD4_21741376_ChIP-Seq_EPCs_Human1.09998933
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09944057
159ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08677137
160NFE2_27457419_Chip-Seq_LIVER_Mouse1.08014159
161AHR_22903824_ChIP-Seq_MCF-7_Human1.07499529
162GATA1_19941826_ChIP-Seq_K562_Human1.06775785
163SPI1_23127762_ChIP-Seq_K562_Human1.05856637
164EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05823560
165NOTCH1_21737748_ChIP-Seq_TLL_Human1.05722069
166TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.05228438
167HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.04905475
168EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03185268
169PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03146121
170CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03023318
171TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02992165
172FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02816942
173* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02251924
174REST_18959480_ChIP-ChIP_MESCs_Mouse1.01691000
175GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01054969
176* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00909576
177TET1_21490601_ChIP-Seq_MESCs_Mouse1.00555381
178RUNX_20019798_ChIP-Seq_JUKART_Human1.00391817
179GATA1_19941827_ChIP-Seq_MEL_Mouse1.00327872
180NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00228151
181TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99942893
182P53_22387025_ChIP-Seq_ESCs_Mouse0.98364054
183* GATA3_21878914_ChIP-Seq_MCF-7_Human0.97906596
184RXR_22108803_ChIP-Seq_LS180_Human0.97658418
185* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96923204
186VDR_21846776_ChIP-Seq_THP-1_Human0.96476822
187FOXA1_25329375_ChIP-Seq_VCAP_Human0.95949735
188FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95949735
189RARB_27405468_Chip-Seq_BRAIN_Mouse0.93332959
190WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92901427
191BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92898554
192NANOG_21062744_ChIP-ChIP_HESCs_Human0.92405248
193NANOG_16518401_ChIP-PET_MESCs_Mouse0.91507554
194ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89564084
195ERG_21242973_ChIP-ChIP_JURKAT_Human0.87491166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.90158189
2MP0003705_abnormal_hypodermis_morpholog3.20463757
3MP0009840_abnormal_foam_cell3.15230428
4MP0003195_calcinosis2.87815097
5MP0005670_abnormal_white_adipose2.86990601
6MP0002254_reproductive_system_inflammat2.72924013
7MP0008877_abnormal_DNA_methylation2.59252906
8MP0005365_abnormal_bile_salt2.49856954
9MP0001661_extended_life_span2.43878118
10MP0003880_abnormal_central_pattern2.42089595
11MP0009046_muscle_twitch2.31913553
12MP0004264_abnormal_extraembryonic_tissu2.31178700
13MP0004185_abnormal_adipocyte_glucose2.21831729
14MP0001968_abnormal_touch/_nociception2.17158795
15MP0003045_fibrosis2.16600728
16MP0009745_abnormal_behavioral_response2.14845698
17MP0010329_abnormal_lipoprotein_level2.11124111
18MP0005551_abnormal_eye_electrophysiolog2.10777483
19MP0008961_abnormal_basal_metabolism2.08807553
20MP0003191_abnormal_cellular_cholesterol2.07538459
21MP0005646_abnormal_pituitary_gland2.01396153
22MP0002102_abnormal_ear_morphology1.96425476
23MP0005666_abnormal_adipose_tissue1.94630386
24MP0004142_abnormal_muscle_tone1.93914643
25MP0006292_abnormal_olfactory_placode1.93229901
26MP0004130_abnormal_muscle_cell1.90210433
27MP0002396_abnormal_hematopoietic_system1.87397069
28MP0002272_abnormal_nervous_system1.85897990
29MP0002653_abnormal_ependyma_morphology1.85640900
30MP0004885_abnormal_endolymph1.81951490
31MP0005174_abnormal_tail_pigmentation1.80319365
32MP0004147_increased_porphyrin_level1.78969810
33MP0005645_abnormal_hypothalamus_physiol1.78037923
34MP0001486_abnormal_startle_reflex1.74154559
35MP0002064_seizures1.72557851
36MP0002876_abnormal_thyroid_physiology1.70956242
37MP0001986_abnormal_taste_sensitivity1.69389343
38MP0002638_abnormal_pupillary_reflex1.69261140
39MP0005076_abnormal_cell_differentiation1.67891086
40MP0001501_abnormal_sleep_pattern1.67739848
41MP0006276_abnormal_autonomic_nervous1.67347924
42MP0008872_abnormal_physiological_respon1.66735673
43MP0000428_abnormal_craniofacial_morphol1.66202252
44MP0003646_muscle_fatigue1.66123656
45MP0000427_abnormal_hair_cycle1.65930923
46MP0000631_abnormal_neuroendocrine_gland1.64061577
47MP0000609_abnormal_liver_physiology1.62255931
48MP0009115_abnormal_fat_cell1.62255231
49MP0001849_ear_inflammation1.61980735
50MP0002736_abnormal_nociception_after1.61563681
51MP0002928_abnormal_bile_duct1.60386893
52* MP0003635_abnormal_synaptic_transmissio1.59951277
53MP0002735_abnormal_chemical_nociception1.57036184
54MP0002088_abnormal_embryonic_growth/wei1.56818658
55MP0003984_embryonic_growth_retardation1.55480762
56MP0001485_abnormal_pinna_reflex1.55477724
57MP0006072_abnormal_retinal_apoptosis1.54046982
58MP0002572_abnormal_emotion/affect_behav1.53779110
59MP0004133_heterotaxia1.53402533
60MP0004742_abnormal_vestibular_system1.52596345
61MP0004043_abnormal_pH_regulation1.52556373
62MP0002063_abnormal_learning/memory/cond1.51926103
63MP0008260_abnormal_autophagy1.51877558
64MP0001672_abnormal_embryogenesis/_devel1.50787165
65MP0005380_embryogenesis_phenotype1.50787165
66MP0004858_abnormal_nervous_system1.50629083
67MP0010352_gastrointestinal_tract_polyps1.50398597
68MP0008995_early_reproductive_senescence1.48446190
69MP0000778_abnormal_nervous_system1.47751680
70MP0005253_abnormal_eye_physiology1.46205588
71MP0002067_abnormal_sensory_capabilities1.43472553
72MP0002092_abnormal_eye_morphology1.41096556
73MP0005423_abnormal_somatic_nervous1.40310137
74MP0002557_abnormal_social/conspecific_i1.39256725
75MP0002970_abnormal_white_adipose1.38471435
76MP0005075_abnormal_melanosome_morpholog1.38279836
77MP0003011_delayed_dark_adaptation1.36105984
78MP0005058_abnormal_lysosome_morphology1.32342016
79MP0003136_yellow_coat_color1.31994086
80MP0002139_abnormal_hepatobiliary_system1.31047798
81MP0005386_behavior/neurological_phenoty1.31011134
82MP0004924_abnormal_behavior1.31011134
83MP0000750_abnormal_muscle_regeneration1.29073930
84MP0000372_irregular_coat_pigmentation1.28255571
85MP0002837_dystrophic_cardiac_calcinosis1.26604781
86MP0002127_abnormal_cardiovascular_syste1.26590458
87MP0001984_abnormal_olfaction1.26190305
88MP0003300_gastrointestinal_ulcer1.24183736
89MP0002166_altered_tumor_susceptibility1.23633215
90MP0003252_abnormal_bile_duct1.23248368
91MP0002971_abnormal_brown_adipose1.22825864
92MP0000733_abnormal_muscle_development1.22385462
93MP0002733_abnormal_thermal_nociception1.22059813
94MP0002269_muscular_atrophy1.21373089
95MP0005375_adipose_tissue_phenotype1.21192854
96MP0003122_maternal_imprinting1.19734550
97MP0001970_abnormal_pain_threshold1.19422259
98MP0004808_abnormal_hematopoietic_stem1.19401351
99MP0002095_abnormal_skin_pigmentation1.16213511
100MP0001502_abnormal_circadian_rhythm1.13440175
101MP0005085_abnormal_gallbladder_physiolo1.13434729
102MP0010307_abnormal_tumor_latency1.13185809
103MP0010386_abnormal_urinary_bladder1.13049953
104MP0000383_abnormal_hair_follicle1.12751399
105MP0003183_abnormal_peptide_metabolism1.12521125
106MP0009278_abnormal_bone_marrow1.12243872
107MP0005084_abnormal_gallbladder_morpholo1.11923827
108MP0002751_abnormal_autonomic_nervous1.09752104
109MP0003718_maternal_effect1.09533502
110MP0005319_abnormal_enzyme/_coenzyme1.07736545
111MP0003890_abnormal_embryonic-extraembry1.07083365
112MP0003566_abnormal_cell_adhesion1.06737464
113MP0010368_abnormal_lymphatic_system1.06117984
114MP0008438_abnormal_cutaneous_collagen1.05986365
115MP0002086_abnormal_extraembryonic_tissu1.05831693
116MP0002118_abnormal_lipid_homeostasis1.05799606
117MP0002909_abnormal_adrenal_gland1.05006111
118MP0008875_abnormal_xenobiotic_pharmacok1.04451665
119MP0002168_other_aberrant_phenotype1.03329960
120MP0002277_abnormal_respiratory_mucosa1.03091189
121MP0000516_abnormal_urinary_system1.03023252
122MP0005367_renal/urinary_system_phenotyp1.03023252
123MP0003787_abnormal_imprinting1.02227331
124MP0001440_abnormal_grooming_behavior1.01747436
125MP0009672_abnormal_birth_weight1.01518970
126MP0005360_urolithiasis1.00839323
127MP0000015_abnormal_ear_pigmentation0.99932884
128MP0003938_abnormal_ear_development0.99102838
129MP0002938_white_spotting0.98460410
130MP0005397_hematopoietic_system_phenotyp0.98357196
131MP0001545_abnormal_hematopoietic_system0.98357196
132MP0005395_other_phenotype0.97920868
133MP0002734_abnormal_mechanical_nocicepti0.96285916
134MP0002160_abnormal_reproductive_system0.95737802
135MP0005257_abnormal_intraocular_pressure0.94161754
136MP0009703_decreased_birth_body0.94000125
137MP0003935_abnormal_craniofacial_develop0.93942285
138MP0004084_abnormal_cardiac_muscle0.93609936
139MP0002882_abnormal_neuron_morphology0.92606525
140MP0004859_abnormal_synaptic_plasticity0.92227626
141MP0005334_abnormal_fat_pad0.91713752
142MP0004145_abnormal_muscle_electrophysio0.91579812
143MP0002752_abnormal_somatic_nervous0.91409846
144MP0003123_paternal_imprinting0.90495931
145MP0003724_increased_susceptibility_to0.89328498
146MP0005195_abnormal_posterior_eye0.88502963
147MP0008770_decreased_survivor_rate0.88248350
148MP0002229_neurodegeneration0.88069028
149MP0000955_abnormal_spinal_cord0.86483987
150MP0002184_abnormal_innervation0.85733257
151MP0001529_abnormal_vocalization0.84448862
152MP0000230_abnormal_systemic_arterial0.84414731
153MP0003119_abnormal_digestive_system0.83847624
154MP0001324_abnormal_eye_pigmentation0.83670725
155MP0003111_abnormal_nucleus_morphology0.83379899
156MP0000538_abnormal_urinary_bladder0.83060296
157MP0005389_reproductive_system_phenotype0.81148554
158MP0003633_abnormal_nervous_system0.80900282
159MP0002925_abnormal_cardiovascular_devel0.80735626
160MP0003091_abnormal_cell_migration0.80504907
161MP0002138_abnormal_hepatobiliary_system0.80217269
162MP0000026_abnormal_inner_ear0.79812795
163MP0005332_abnormal_amino_acid0.79510696
164MP0000350_abnormal_cell_proliferation0.79293560
165MP0001756_abnormal_urination0.79078460
166MP0005621_abnormal_cell_physiology0.78445258
167MP0000747_muscle_weakness0.78418471
168MP0003698_abnormal_male_reproductive0.78289713
169MP0000598_abnormal_liver_morphology0.78144089
170MP0004019_abnormal_vitamin_homeostasis0.78071838
171MP0003943_abnormal_hepatobiliary_system0.77715508
172MP0010234_abnormal_vibrissa_follicle0.77289170
173MP0005275_abnormal_skin_tensile0.76653365
174MP0005197_abnormal_uvea_morphology0.75124266
175MP0010630_abnormal_cardiac_muscle0.74590956
176MP0004947_skin_inflammation0.74198603
177MP0006138_congestive_heart_failure0.72630964
178MP0002332_abnormal_exercise_endurance0.72445532
179MP0000767_abnormal_smooth_muscle0.72414013
180MP0005023_abnormal_wound_healing0.71917182
181MP0002084_abnormal_developmental_patter0.71118583
182MP0003121_genomic_imprinting0.69844742
183MP0003879_abnormal_hair_cell0.69611133
184MP0000627_abnormal_mammary_gland0.69265242
185MP0010678_abnormal_skin_adnexa0.69200049
186MP0005248_abnormal_Harderian_gland0.69041915

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.44837890
2Hyperventilation (HP:0002883)4.33519117
3Molar tooth sign on MRI (HP:0002419)4.02041330
4Abnormality of midbrain morphology (HP:0002418)4.02041330
5Pancreatic fibrosis (HP:0100732)3.97690807
6True hermaphroditism (HP:0010459)3.95449259
7Progressive cerebellar ataxia (HP:0002073)3.84967081
8Hyperglycinemia (HP:0002154)3.65650649
9Hyperglycinuria (HP:0003108)3.59293086
10Nephronophthisis (HP:0000090)3.55152424
11Abnormality of the renal medulla (HP:0100957)3.25699050
12Abnormality of the lower motor neuron (HP:0002366)3.13383690
13Abnormality of the renal cortex (HP:0011035)3.11375167
14Febrile seizures (HP:0002373)2.99898416
15Gaze-evoked nystagmus (HP:0000640)2.97376039
16Abnormality of the fingertips (HP:0001211)2.96471324
17Broad-based gait (HP:0002136)2.87931078
18Chronic hepatic failure (HP:0100626)2.87791064
19Macroorchidism (HP:0000053)2.87144942
20Stomach cancer (HP:0012126)2.85045419
21Medial flaring of the eyebrow (HP:0010747)2.83227810
22Cerebral aneurysm (HP:0004944)2.81609551
23Absent speech (HP:0001344)2.80922391
24Abnormality of serine family amino acid metabolism (HP:0010894)2.80002192
25Abnormality of glycine metabolism (HP:0010895)2.80002192
26Tetraplegia (HP:0002445)2.79423606
27Cystic liver disease (HP:0006706)2.78693491
28Hypochromic microcytic anemia (HP:0004840)2.77701493
29Enlarged penis (HP:0000040)2.76904454
30Shallow orbits (HP:0000586)2.68025083
31Ependymoma (HP:0002888)2.67454011
32Type II lissencephaly (HP:0007260)2.67313125
33Oligodactyly (hands) (HP:0001180)2.63942721
34Attenuation of retinal blood vessels (HP:0007843)2.62086992
35Atrioventricular block (HP:0001678)2.53831749
36Inability to walk (HP:0002540)2.53392851
37Heterotopia (HP:0002282)2.49948581
38Birth length less than 3rd percentile (HP:0003561)2.49428195
39Submucous cleft hard palate (HP:0000176)2.49292936
40Protruding tongue (HP:0010808)2.49081605
41Focal seizures (HP:0007359)2.46352964
42Bundle branch block (HP:0011710)2.45398691
43Focal motor seizures (HP:0011153)2.42698838
44Ankle contracture (HP:0006466)2.38971123
45Hypothermia (HP:0002045)2.38901818
46Impulsivity (HP:0100710)2.38716949
47Furrowed tongue (HP:0000221)2.38000823
48Premature rupture of membranes (HP:0001788)2.36851144
49Widely spaced teeth (HP:0000687)2.36039317
50Fair hair (HP:0002286)2.35624113
51Gait imbalance (HP:0002141)2.35332060
52Gout (HP:0001997)2.35163517
53Concave nail (HP:0001598)2.34764946
54Abnormal drinking behavior (HP:0030082)2.31972800
55Polydipsia (HP:0001959)2.31972800
56Large for gestational age (HP:0001520)2.31785108
57Renal cortical cysts (HP:0000803)2.31780767
58Broad metatarsal (HP:0001783)2.31466311
59Astrocytoma (HP:0009592)2.30391533
60Abnormality of the astrocytes (HP:0100707)2.30391533
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.30354821
62Hepatoblastoma (HP:0002884)2.28374385
63Abolished electroretinogram (ERG) (HP:0000550)2.27127432
64Abnormality of alanine metabolism (HP:0010916)2.26152116
65Hyperalaninemia (HP:0003348)2.26152116
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26152116
67Prominent nose (HP:0000448)2.24037162
68Osteolytic defects of the hand bones (HP:0009699)2.23737035
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.23737035
70Narrow palate (HP:0000189)2.23247630
71Pustule (HP:0200039)2.22691672
72Tubular atrophy (HP:0000092)2.19372779
73Complement deficiency (HP:0004431)2.19200778
74Lissencephaly (HP:0001339)2.19173790
75Testicular atrophy (HP:0000029)2.17947910
76Hemiparesis (HP:0001269)2.16984683
77Congenital primary aphakia (HP:0007707)2.16613641
78Abnormality of liposaccharide metabolism (HP:0010968)2.15246975
79Abnormality of glycosphingolipid metabolism (HP:0004343)2.15246975
80Abnormality of glycolipid metabolism (HP:0010969)2.15246975
81Clumsiness (HP:0002312)2.14450935
82Mitral valve prolapse (HP:0001634)2.14039380
83Aplasia/Hypoplasia of the tongue (HP:0010295)2.13772076
84Congenital hepatic fibrosis (HP:0002612)2.12756545
85Aneurysm (HP:0002617)2.11827675
86Decreased circulating renin level (HP:0003351)2.11170093
87Sclerocornea (HP:0000647)2.10842753
88Patellar aplasia (HP:0006443)2.08500476
89Dynein arm defect of respiratory motile cilia (HP:0012255)2.06990524
90Absent/shortened dynein arms (HP:0200106)2.06990524
91Vertebral arch anomaly (HP:0008438)2.05646385
92Anencephaly (HP:0002323)2.05607079
93Pseudobulbar signs (HP:0002200)2.04449389
94Disproportionate tall stature (HP:0001519)2.04333549
95Keratoconus (HP:0000563)2.02237915
96Increased corneal curvature (HP:0100692)2.02237915
97Genetic anticipation (HP:0003743)2.01607543
98Dysmetric saccades (HP:0000641)2.00453674
99Male pseudohermaphroditism (HP:0000037)1.99558518
100Oligodactyly (HP:0012165)1.98988264
101Neoplasm of the heart (HP:0100544)1.97169540
102Nephrogenic diabetes insipidus (HP:0009806)1.97088359
103Generalized hypopigmentation of hair (HP:0011358)1.96571556
104Hand muscle atrophy (HP:0009130)1.96541193
105Aplasia/Hypoplasia of the patella (HP:0006498)1.96032878
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.95688331
107Genital tract atresia (HP:0001827)1.94819076
108Spastic tetraparesis (HP:0001285)1.94805963
109Upper motor neuron abnormality (HP:0002127)1.93987812
110Difficulty running (HP:0009046)1.93975492
111Ventricular fibrillation (HP:0001663)1.93281634
112Decreased central vision (HP:0007663)1.93104680
113Skin nodule (HP:0200036)1.92237191
114Excessive salivation (HP:0003781)1.92094332
115Drooling (HP:0002307)1.92094332
116Progressive inability to walk (HP:0002505)1.91560139
117Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.91500299
118Myocardial infarction (HP:0001658)1.90938275
119Congenital sensorineural hearing impairment (HP:0008527)1.90891610
120Epileptic encephalopathy (HP:0200134)1.89844995
121Dialeptic seizures (HP:0011146)1.89408714
122Poor coordination (HP:0002370)1.88883500
123Aortic aneurysm (HP:0004942)1.87956306
124Abnormal biliary tract physiology (HP:0012439)1.87869909
125Bile duct proliferation (HP:0001408)1.87869909
126Chorioretinal atrophy (HP:0000533)1.87332099
127Abnormal rod and cone electroretinograms (HP:0008323)1.87093982
128Glioma (HP:0009733)1.86653742
129Thyroid-stimulating hormone excess (HP:0002925)1.86052574
130Multiple enchondromatosis (HP:0005701)1.86038196
131Vaginal atresia (HP:0000148)1.85283961
132Congenital, generalized hypertrichosis (HP:0004540)1.84921482
133Pachygyria (HP:0001302)1.84879882
134Distal upper limb amyotrophy (HP:0007149)1.81472654
135Upper limb amyotrophy (HP:0009129)1.81472654
136Global brain atrophy (HP:0002283)1.79012390
137Atonic seizures (HP:0010819)1.78617947
138Hypoplastic nipples (HP:0002557)1.78390937
139Deep venous thrombosis (HP:0002625)1.76371812
140Postaxial foot polydactyly (HP:0001830)1.76014982
141Bulbous nose (HP:0000414)1.75868512
142Optic nerve hypoplasia (HP:0000609)1.74790112
143Supernumerary nipples (HP:0002558)1.73480586
144Bilateral microphthalmos (HP:0007633)1.73313697
145Anal stenosis (HP:0002025)1.70956846
146Bony spicule pigmentary retinopathy (HP:0007737)1.70371134
147Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69292063
148Agitation (HP:0000713)1.67975239
149Severe muscular hypotonia (HP:0006829)1.67783356
150Polyuria (HP:0000103)1.67656815
151Open mouth (HP:0000194)1.67177503
152Polycythemia (HP:0001901)1.67144748
153Aqueductal stenosis (HP:0002410)1.67136330
154Cheilitis (HP:0100825)1.66600977
155Abnormal respiratory motile cilium morphology (HP:0005938)1.65927601
156Abnormal respiratory epithelium morphology (HP:0012253)1.65927601
157Cupped ear (HP:0000378)1.65807860
158Protrusio acetabuli (HP:0003179)1.65793842
159Hyperglycemia (HP:0003074)1.65515414
160Leiomyosarcoma (HP:0100243)1.64630367
161Uterine leiomyosarcoma (HP:0002891)1.64630367
162Abnormality of the pubic bones (HP:0003172)1.64600400
163Cerebellar dysplasia (HP:0007033)1.64462119
164Postaxial hand polydactyly (HP:0001162)1.64366594
165Status epilepticus (HP:0002133)1.64186803
166Dyskinesia (HP:0100660)1.62853165
167Dilatation of the ascending aorta (HP:0005111)1.62843256
168Sparse lateral eyebrow (HP:0005338)1.62589253
169Increased connective tissue (HP:0009025)1.62411374
170Pendular nystagmus (HP:0012043)1.62099394
171Hypoplastic labia majora (HP:0000059)1.61339717
172Hyperacusis (HP:0010780)1.61062414
173Abnormality of the distal phalanges of the toes (HP:0010182)1.60491123
174Tented upper lip vermilion (HP:0010804)1.60210233
175Entropion (HP:0000621)1.60192533
176Transitional cell carcinoma of the bladder (HP:0006740)1.59719688
177Congenital stationary night blindness (HP:0007642)1.59035275
178Skin tags (HP:0010609)1.58703470
179Abnormality of the Achilles tendon (HP:0005109)1.57586294
180Wrist flexion contracture (HP:0001239)1.57437036
181Abnormal cartilage morphology (HP:0002763)1.56506271
182Generalized hypotonia (HP:0001290)1.56368753
183EMG: neuropathic changes (HP:0003445)1.54216076
184Hyperlipoproteinemia (HP:0010980)1.52959543
185Achilles tendon contracture (HP:0001771)1.52747009
186Heart block (HP:0012722)1.52167257
187Lymphangioma (HP:0100764)1.51659301
188Absent hand (HP:0004050)1.50754743
189Restlessness (HP:0000711)1.50730988
190Muscle fiber splitting (HP:0003555)1.48490843
191Increased CSF protein (HP:0002922)1.46180614
192Renal cell carcinoma (HP:0005584)1.45755579
193Long eyelashes (HP:0000527)1.45742646
194Elfin facies (HP:0004428)1.44057773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.89172381
2CDK124.63416915
3BMPR1B3.74474426
4CAMK1D3.56615737
5ACVR1B3.21016118
6CAMK1G2.94619905
7CASK2.71142345
8AKT32.68202908
9MAP4K22.64680071
10ADRBK22.58413537
11ERN12.55512803
12WNK32.52189070
13SIK12.40673372
14MARK12.21605817
15LATS12.16583944
16TRIB32.11627141
17MAPK132.10819079
18TGFBR21.94541016
19MAP3K41.84647999
20STK381.84635538
21GRK51.83319828
22MAP3K91.74362195
23WNK41.72547196
24STK31.66580396
25DAPK21.66241413
26EEF2K1.64715392
27NTRK31.63895266
28FGFR31.61551289
29MAP3K71.59171821
30GRK61.54182061
31RIPK11.49160350
32TAOK31.48693423
33WNK11.47840538
34ALK1.47535735
35TLK11.46500676
36MAPK71.42808379
37TGFBR11.41745894
38FGFR41.40177068
39SIK21.37178087
40CSF1R1.35786914
41MTOR1.35074685
42NEK21.34679003
43TYRO31.34318587
44OXSR11.33798959
45PDGFRA1.29357737
46CAMKK21.28985446
47PKN21.26902879
48TAOK11.26535530
49CAMK41.25690599
50MARK21.22684690
51INSRR1.22135445
52PIK3CA1.20991985
53PRKAA11.18419570
54ADRBK11.14924385
55MAP3K131.13982758
56MAP3K101.13492628
57GRK11.13271552
58FGFR21.11548421
59PAK61.09802386
60NTRK21.09219425
61NTRK11.08854234
62STK101.03438366
63LATS21.03170193
64LMTK21.02412026
65BRD41.02367222
66TSSK61.02282225
67KSR21.02251828
68SGK31.01943603
69CDK61.01015661
70MAP2K71.00970582
71STK391.00698044
72TYK20.98775760
73TXK0.98628759
74ZAK0.97810606
75TTK0.93026464
76PRKAA20.92443378
77ICK0.89943107
78JAK10.89825867
79PTK20.86674842
80DYRK20.86077877
81TNIK0.85237026
82PDGFRB0.84671794
83MAPK150.84463048
84CAMKK10.83392619
85SGK4940.83161261
86SGK2230.83161261
87MKNK20.83087922
88STK110.82215688
89EPHA40.80706564
90RET0.77273969
91CAMK10.77030687
92PRKCE0.75625761
93IRAK10.73620005
94JAK20.72393782
95PRKCG0.71210730
96TNK20.70041554
97PINK10.69736361
98PRKD20.68283125
99PDK10.67601514
100PTK2B0.67182097
101MAP2K40.66898208
102MAPK120.66789733
103STK38L0.66616685
104EPHA20.66262994
105BCR0.64599142
106EPHA30.63657943
107DDR20.63514091
108RIPK40.62310777
109CDK40.61575237
110KIT0.60569981
111MAPK100.59814962
112PKN10.58847640
113PLK20.58709255
114PAK30.58476912
115TEC0.58460322
116PDPK10.57627222
117ERBB20.56172694
118TTN0.56010157
119CSNK1G20.55326003
120PRKCZ0.54862692
121MAP4K10.52649217
122PAK20.50981859
123BCKDK0.50906493
124PNCK0.50687092
125DYRK1A0.50628008
126CHUK0.50563973
127SYK0.50384542
128RAF10.50355644
129NLK0.50284034
130MAP2K60.49990654
131HIPK20.49609794
132FLT30.49264067
133CAMK2A0.48177870
134SGK10.47710019
135IKBKB0.47625244
136SGK20.47459629
137BMX0.46570214
138HCK0.45514192
139RPS6KA50.45464618
140DYRK1B0.44656597
141MAPK110.44424850
142PRKCH0.43912171
143FGFR10.43108200
144MAP2K10.42956458
145PTK60.42474052
146PRKCQ0.41876200
147MARK30.41722776
148MAPK80.41603541
149MATK0.41139952
150CSNK1D0.40531951
151CSNK1G10.40213582
152CHEK20.39696873
153NUAK10.39646743
154CSNK1A1L0.39292738
155PRKACA0.39066871
156ITK0.39051125
157PHKG10.38902199
158PHKG20.38902199
159MELK0.37947379
160CDK50.37110460
161EPHB10.36329266
162KSR10.36196192
163MAP3K20.36195209
164STK240.35922713
165MOS0.35010872
166LYN0.33693803
167PRKG10.32018968
168CSNK1G30.31965253
169TIE10.31905383
170ERBB30.31664343
171BRSK20.30692947

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.18723603
2Nicotine addiction_Homo sapiens_hsa050333.11972057
3Phototransduction_Homo sapiens_hsa047442.71812926
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39002646
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35069908
6Linoleic acid metabolism_Homo sapiens_hsa005912.33388018
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.22752555
8Nitrogen metabolism_Homo sapiens_hsa009102.20609531
9mTOR signaling pathway_Homo sapiens_hsa041502.08049224
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.06198394
11Butanoate metabolism_Homo sapiens_hsa006502.05824713
12Morphine addiction_Homo sapiens_hsa050322.01749030
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99607288
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.98319687
15Selenocompound metabolism_Homo sapiens_hsa004501.97286843
16Ether lipid metabolism_Homo sapiens_hsa005651.82947656
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.82694946
18Taste transduction_Homo sapiens_hsa047421.78258217
19Circadian entrainment_Homo sapiens_hsa047131.75734460
20Regulation of autophagy_Homo sapiens_hsa041401.70078970
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66821802
22Glutamatergic synapse_Homo sapiens_hsa047241.57196348
23GABAergic synapse_Homo sapiens_hsa047271.56324895
24Olfactory transduction_Homo sapiens_hsa047401.54321594
25Insulin secretion_Homo sapiens_hsa049111.49300007
26Circadian rhythm_Homo sapiens_hsa047101.44399492
27Lysine degradation_Homo sapiens_hsa003101.42859572
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37051257
29Serotonergic synapse_Homo sapiens_hsa047261.36661078
30Glycerolipid metabolism_Homo sapiens_hsa005611.35823671
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34325080
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33387400
33Longevity regulating pathway - mammal_Homo sapiens_hsa042111.28959829
34Cocaine addiction_Homo sapiens_hsa050301.28483793
35Basal transcription factors_Homo sapiens_hsa030221.24092319
36Arginine biosynthesis_Homo sapiens_hsa002201.24018529
37Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23774998
38Dopaminergic synapse_Homo sapiens_hsa047281.23342141
39Complement and coagulation cascades_Homo sapiens_hsa046101.22599365
40Fructose and mannose metabolism_Homo sapiens_hsa000511.21519381
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.20714885
42AMPK signaling pathway_Homo sapiens_hsa041521.18894081
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16399407
44Collecting duct acid secretion_Homo sapiens_hsa049661.15731905
45Amphetamine addiction_Homo sapiens_hsa050311.15281802
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14766390
47Cholinergic synapse_Homo sapiens_hsa047251.13548357
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13327747
49PPAR signaling pathway_Homo sapiens_hsa033201.12102761
50Insulin resistance_Homo sapiens_hsa049311.12072170
51Inositol phosphate metabolism_Homo sapiens_hsa005621.10851554
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09874612
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.05424162
54Non-small cell lung cancer_Homo sapiens_hsa052231.04544407
55Calcium signaling pathway_Homo sapiens_hsa040201.03505373
56Dorso-ventral axis formation_Homo sapiens_hsa043201.02907824
57Adipocytokine signaling pathway_Homo sapiens_hsa049201.02886798
58Fatty acid biosynthesis_Homo sapiens_hsa000611.02617834
59ABC transporters_Homo sapiens_hsa020101.01652033
60Long-term depression_Homo sapiens_hsa047301.00195736
61Chronic myeloid leukemia_Homo sapiens_hsa052200.99766511
62Choline metabolism in cancer_Homo sapiens_hsa052310.99076460
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.97515537
64Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96972704
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96490851
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95055514
67Fanconi anemia pathway_Homo sapiens_hsa034600.94609061
68Renal cell carcinoma_Homo sapiens_hsa052110.94525801
69Peroxisome_Homo sapiens_hsa041460.93351568
70Oxidative phosphorylation_Homo sapiens_hsa001900.93314508
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.93201701
72FoxO signaling pathway_Homo sapiens_hsa040680.92984899
73Caffeine metabolism_Homo sapiens_hsa002320.92343641
74Acute myeloid leukemia_Homo sapiens_hsa052210.92124114
75Staphylococcus aureus infection_Homo sapiens_hsa051500.91448701
76Bile secretion_Homo sapiens_hsa049760.91121371
77Intestinal immune network for IgA production_Homo sapiens_hsa046720.90782870
78Endometrial cancer_Homo sapiens_hsa052130.89419052
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87749522
80Insulin signaling pathway_Homo sapiens_hsa049100.83962036
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.83493635
82Central carbon metabolism in cancer_Homo sapiens_hsa052300.83399863
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82596184
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81014234
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80972776
86Glioma_Homo sapiens_hsa052140.79070299
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78949870
88Type II diabetes mellitus_Homo sapiens_hsa049300.78520882
89ErbB signaling pathway_Homo sapiens_hsa040120.78369721
90Gastric acid secretion_Homo sapiens_hsa049710.77227369
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.76363528
92RNA degradation_Homo sapiens_hsa030180.75887486
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74421240
94Proteoglycans in cancer_Homo sapiens_hsa052050.74216158
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73415371
96Pentose phosphate pathway_Homo sapiens_hsa000300.72337891
97Pancreatic cancer_Homo sapiens_hsa052120.71329437
98MicroRNAs in cancer_Homo sapiens_hsa052060.71271271
99B cell receptor signaling pathway_Homo sapiens_hsa046620.69841926
100Chemical carcinogenesis_Homo sapiens_hsa052040.69685298
101Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69244673
102Propanoate metabolism_Homo sapiens_hsa006400.68883506
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68201039
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68154439
105Fatty acid metabolism_Homo sapiens_hsa012120.67864845
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.67529401
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.66704123
108Arachidonic acid metabolism_Homo sapiens_hsa005900.66203006
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.65860412
110Renin secretion_Homo sapiens_hsa049240.65722309
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65131604
112Fatty acid degradation_Homo sapiens_hsa000710.64825576
113Cardiac muscle contraction_Homo sapiens_hsa042600.64125664
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63042350
115Axon guidance_Homo sapiens_hsa043600.62275394
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61494930
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61375322
118Vitamin digestion and absorption_Homo sapiens_hsa049770.60581967
119Homologous recombination_Homo sapiens_hsa034400.59625044
120Lysosome_Homo sapiens_hsa041420.59544454
121Small cell lung cancer_Homo sapiens_hsa052220.58841614
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.58747052
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58496662
124Protein export_Homo sapiens_hsa030600.57520561
125Colorectal cancer_Homo sapiens_hsa052100.57493260
126GnRH signaling pathway_Homo sapiens_hsa049120.56815605
127Salivary secretion_Homo sapiens_hsa049700.56606592
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.56530566
129Folate biosynthesis_Homo sapiens_hsa007900.54471293
130Histidine metabolism_Homo sapiens_hsa003400.54430453
131Parkinsons disease_Homo sapiens_hsa050120.52794708
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52490679
133Retinol metabolism_Homo sapiens_hsa008300.50878221
134Estrogen signaling pathway_Homo sapiens_hsa049150.50846838
135Prolactin signaling pathway_Homo sapiens_hsa049170.49436462
136Adherens junction_Homo sapiens_hsa045200.49080973
137Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49049552
138Dilated cardiomyopathy_Homo sapiens_hsa054140.48761482
139Tryptophan metabolism_Homo sapiens_hsa003800.48747549
140Rap1 signaling pathway_Homo sapiens_hsa040150.48511620
141VEGF signaling pathway_Homo sapiens_hsa043700.48313900
142Oxytocin signaling pathway_Homo sapiens_hsa049210.48065532
143Ras signaling pathway_Homo sapiens_hsa040140.48001805
144Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47858008
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47762984
146Mineral absorption_Homo sapiens_hsa049780.46825772
147Notch signaling pathway_Homo sapiens_hsa043300.46811084
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46693676
149cAMP signaling pathway_Homo sapiens_hsa040240.46579752
150RNA polymerase_Homo sapiens_hsa030200.46565001
151Focal adhesion_Homo sapiens_hsa045100.45621158
152Ovarian steroidogenesis_Homo sapiens_hsa049130.45568933
153Pancreatic secretion_Homo sapiens_hsa049720.45239331
154Endocytosis_Homo sapiens_hsa041440.44828713
155Glucagon signaling pathway_Homo sapiens_hsa049220.43826765
156Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43084137
157T cell receptor signaling pathway_Homo sapiens_hsa046600.42755751
158Pathways in cancer_Homo sapiens_hsa052000.41812516
159AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41734851
160p53 signaling pathway_Homo sapiens_hsa041150.40870489
161Prostate cancer_Homo sapiens_hsa052150.40692068
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40508531
163Sulfur metabolism_Homo sapiens_hsa009200.40286412
164Synaptic vesicle cycle_Homo sapiens_hsa047210.40100250
165Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39446944
166cGMP-PKG signaling pathway_Homo sapiens_hsa040220.37641447
167Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37510675
168Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37223324
169MAPK signaling pathway_Homo sapiens_hsa040100.37174273
170SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35880361
171Huntingtons disease_Homo sapiens_hsa050160.35725573
172beta-Alanine metabolism_Homo sapiens_hsa004100.33696311
173Fat digestion and absorption_Homo sapiens_hsa049750.33207680

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