FBXL21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of plasminogen activation (GO:0010755)7.16486779
2negative regulation of macroautophagy (GO:0016242)6.10838995
3bone trabecula formation (GO:0060346)5.61156193
4DNA damage induced protein phosphorylation (GO:0006975)5.48641421
5L-phenylalanine catabolic process (GO:0006559)5.03549582
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.03549582
7actin filament depolymerization (GO:0030042)4.89616094
8facial nerve structural organization (GO:0021612)4.69735233
9L-phenylalanine metabolic process (GO:0006558)4.43907821
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.43907821
11establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.33758540
12mitochondrion transport along microtubule (GO:0047497)4.33758540
13mannose metabolic process (GO:0006013)4.33046002
14aromatic amino acid family catabolic process (GO:0009074)4.25280551
15negative regulation of smooth muscle cell migration (GO:0014912)4.19366339
16nephron tubule morphogenesis (GO:0072078)4.09151609
17nephron epithelium morphogenesis (GO:0072088)4.09151609
18fibrinolysis (GO:0042730)3.99894509
19semaphorin-plexin signaling pathway (GO:0071526)3.92953574
20oocyte maturation (GO:0001556)3.90684329
21kidney mesenchyme development (GO:0072074)3.89846822
22lung vasculature development (GO:0060426)3.88803219
23positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.87152503
24mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.87152503
25sulfate transport (GO:0008272)3.76389368
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.67503569
27negative regulation of fatty acid biosynthetic process (GO:0045717)3.64679376
28indole-containing compound catabolic process (GO:0042436)3.64283898
29indolalkylamine catabolic process (GO:0046218)3.64283898
30tryptophan catabolic process (GO:0006569)3.64283898
31sulfate transmembrane transport (GO:1902358)3.62076417
32synaptic vesicle docking involved in exocytosis (GO:0016081)3.55011964
33vocalization behavior (GO:0071625)3.53149852
34regulation of ARF GTPase activity (GO:0032312)3.52470750
35cellular response to prostaglandin stimulus (GO:0071379)3.50068529
36high-density lipoprotein particle remodeling (GO:0034375)3.50007132
37cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.48378084
38establishment of mitochondrion localization (GO:0051654)3.45200961
39histone deubiquitination (GO:0016578)3.44794856
40coenzyme catabolic process (GO:0009109)3.41565587
41neuromuscular process controlling posture (GO:0050884)3.39876336
42urogenital system development (GO:0001655)3.37939094
43tryptophan metabolic process (GO:0006568)3.37618021
44viral mRNA export from host cell nucleus (GO:0046784)3.36667158
45mesenchyme morphogenesis (GO:0072132)3.35813499
46embryonic skeletal joint morphogenesis (GO:0060272)3.34299094
47negative regulation of autophagy (GO:0010507)3.34042159
48metanephric mesenchyme development (GO:0072075)3.32136124
49cranial nerve structural organization (GO:0021604)3.31506339
50positive regulation of smoothened signaling pathway (GO:0045880)3.30905690
51endothelial cell chemotaxis (GO:0035767)3.30417680
52snRNA processing (GO:0016180)3.29860976
53axon extension involved in axon guidance (GO:0048846)3.28216455
54neuron projection extension involved in neuron projection guidance (GO:1902284)3.28216455
55regulation of axon extension involved in axon guidance (GO:0048841)3.26823154
56kynurenine metabolic process (GO:0070189)3.25546457
57very-low-density lipoprotein particle assembly (GO:0034379)3.22186610
58mRNA polyadenylation (GO:0006378)3.18423244
59histone H4 deacetylation (GO:0070933)3.18393992
60cellular glucuronidation (GO:0052695)3.17830046
61snRNA metabolic process (GO:0016073)3.16797892
62homocysteine metabolic process (GO:0050667)3.16382280
63bile acid biosynthetic process (GO:0006699)3.16359133
64negative regulation of chondrocyte differentiation (GO:0032331)3.16094445
65positive regulation of monocyte chemotaxis (GO:0090026)3.15034175
66regulation of short-term neuronal synaptic plasticity (GO:0048172)3.14873237
67reverse cholesterol transport (GO:0043691)3.09153122
68negative regulation of endothelial cell apoptotic process (GO:2000352)3.09144817
69sulfur amino acid catabolic process (GO:0000098)3.04798827
70negative regulation of cell size (GO:0045792)3.04093191
71activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.03993995
72uronic acid metabolic process (GO:0006063)3.03603539
73glucuronate metabolic process (GO:0019585)3.03603539
74cranial nerve morphogenesis (GO:0021602)3.02170378
75negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01337243
76synaptic vesicle exocytosis (GO:0016079)3.00502929
77positive regulation of nuclease activity (GO:0032075)2.99820621
78regulation of cholesterol esterification (GO:0010872)2.99053637
79drug catabolic process (GO:0042737)2.98792552
80urea cycle (GO:0000050)2.96177329
81urea metabolic process (GO:0019627)2.96177329
82aromatic amino acid family metabolic process (GO:0009072)2.95285620
83cellular ketone body metabolic process (GO:0046950)2.95262863
84regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94855836
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94749112
86desmosome organization (GO:0002934)2.93889174
87negative regulation of dendrite morphogenesis (GO:0050774)2.93815740
88cell proliferation involved in metanephros development (GO:0072203)2.92540868
89RNA polyadenylation (GO:0043631)2.90629763
90gamma-aminobutyric acid transport (GO:0015812)2.90193759
91bile acid metabolic process (GO:0008206)2.89721579
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89223419
93histone H4-K12 acetylation (GO:0043983)2.88326046
94neurotransmitter-gated ion channel clustering (GO:0072578)2.88019983
95negative regulation of protein activation cascade (GO:2000258)2.86874173
96protein carboxylation (GO:0018214)2.86474410
97peptidyl-glutamic acid carboxylation (GO:0017187)2.86474410
98amine catabolic process (GO:0009310)2.86330599
99cellular biogenic amine catabolic process (GO:0042402)2.86330599
100pyrimidine nucleobase catabolic process (GO:0006208)2.85528071
101glutamate metabolic process (GO:0006536)2.84114035
102regulation of glutamate secretion (GO:0014048)2.82235556
103regulation of axon guidance (GO:1902667)2.82228822
104axonal fasciculation (GO:0007413)2.81497630
105regulation of glutamate receptor signaling pathway (GO:1900449)2.80641273
106positive regulation of hemostasis (GO:1900048)2.79275757
107positive regulation of blood coagulation (GO:0030194)2.79275757
108negative regulation of response to extracellular stimulus (GO:0032105)2.78950306
109negative regulation of response to nutrient levels (GO:0032108)2.78950306
110plasma lipoprotein particle remodeling (GO:0034369)2.78756926
111protein-lipid complex remodeling (GO:0034368)2.78756926
112macromolecular complex remodeling (GO:0034367)2.78756926
113positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78010154
114negative regulation of dendrite development (GO:2000171)2.77915747
115vitamin transmembrane transport (GO:0035461)2.76669687
116neuron recognition (GO:0008038)2.76658341
117phospholipid efflux (GO:0033700)2.76516265
118glyoxylate metabolic process (GO:0046487)2.75211180
119plasma lipoprotein particle assembly (GO:0034377)2.74943519
120nitrogen cycle metabolic process (GO:0071941)2.74798310
121negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.74622390
122positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.73569229
123regulation of protein activation cascade (GO:2000257)2.72609849
124histone H3 deacetylation (GO:0070932)2.71737730
125bile acid and bile salt transport (GO:0015721)2.71607306
126negative chemotaxis (GO:0050919)2.71274696
127cysteine metabolic process (GO:0006534)2.70978114
128NAD biosynthetic process (GO:0009435)2.70540742
129regulation of cholesterol metabolic process (GO:0090181)2.68865948
130regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.68085747
131low-density lipoprotein particle remodeling (GO:0034374)2.67638865
132renal tubule morphogenesis (GO:0061333)2.67519836
133negative regulation of DNA repair (GO:0045738)2.67199478
134cellular response to epidermal growth factor stimulus (GO:0071364)2.67048092
135alpha-amino acid catabolic process (GO:1901606)2.66863856
136positive regulation of dendrite morphogenesis (GO:0050775)2.66774329
137exogenous drug catabolic process (GO:0042738)2.66479359
138neurotransmitter secretion (GO:0007269)2.66069454
139regulation of nuclease activity (GO:0032069)2.66000388
140cholesterol efflux (GO:0033344)2.65192739
141negative regulation of complement activation (GO:0045916)2.64691996
142glutamate receptor signaling pathway (GO:0007215)2.62517048
143glutamate secretion (GO:0014047)2.62205380
144transmission of nerve impulse (GO:0019226)2.60751821
145regulation of fibrinolysis (GO:0051917)2.60467253
146stress granule assembly (GO:0034063)2.59881392
147regulation of female receptivity (GO:0045924)2.59656083
148chondrocyte proliferation (GO:0035988)2.59511565
149sympathetic nervous system development (GO:0048485)2.57135702
150nucleobase catabolic process (GO:0046113)2.56496542
151gamma-aminobutyric acid signaling pathway (GO:0007214)2.56098132
152positive regulation of mitochondrial membrane permeability (GO:0035794)2.56026597
153indolalkylamine metabolic process (GO:0006586)2.55546195
154opsonization (GO:0008228)2.55051969
155neuron cell-cell adhesion (GO:0007158)2.54818426
156nucleotide transmembrane transport (GO:1901679)2.54261096
157presynaptic membrane assembly (GO:0097105)2.54168945
158behavioral response to nicotine (GO:0035095)2.53777248
159pattern specification involved in kidney development (GO:0061004)2.53674471
160spliceosomal tri-snRNP complex assembly (GO:0000244)2.53263217
161xenobiotic catabolic process (GO:0042178)2.52954707
162female mating behavior (GO:0060180)2.52412946
163regulation of complement activation (GO:0030449)2.51830745
164tyrosine metabolic process (GO:0006570)2.51775916
165cofactor catabolic process (GO:0051187)2.51511953
166negative regulation of fibrinolysis (GO:0051918)2.51174877
167positive regulation of cell cycle checkpoint (GO:1901978)2.50819381
168substrate-dependent cell migration (GO:0006929)2.49776288
169ketone body metabolic process (GO:1902224)2.49460596
170response to pheromone (GO:0019236)2.48992447
171diacylglycerol metabolic process (GO:0046339)2.48913013
172endocardial cushion morphogenesis (GO:0003203)2.48480918
173regulation of histone H3-K27 methylation (GO:0061085)2.47975900
174cellular amino acid catabolic process (GO:0009063)2.47741060
175atrial septum morphogenesis (GO:0060413)2.46834495
176regulation of beta-amyloid formation (GO:1902003)2.45467801
177negative regulation of mRNA processing (GO:0050686)2.45015387
178lung epithelium development (GO:0060428)2.44744854
179negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44510846
180regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.44223922
181dicarboxylic acid catabolic process (GO:0043649)2.43196540
182endothelial cell morphogenesis (GO:0001886)2.42777412
183mesodermal cell differentiation (GO:0048333)2.41965701
184regulation of neuronal synaptic plasticity (GO:0048168)2.41622617
185protein localization to synapse (GO:0035418)2.41619080
186positive regulation of coagulation (GO:0050820)2.41484253
187regulation of DNA damage checkpoint (GO:2000001)2.41403905
188response to prostaglandin (GO:0034694)2.41105994
189imidazole-containing compound metabolic process (GO:0052803)2.39995298
190cellular modified amino acid catabolic process (GO:0042219)2.39504899
191positive regulation of amino acid transport (GO:0051957)2.38635830
192complement activation, alternative pathway (GO:0006957)2.38465150
193positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.37595860
194regulation of bile acid biosynthetic process (GO:0070857)2.37242128
195serine family amino acid catabolic process (GO:0009071)2.36270570
196regulation of amino acid transport (GO:0051955)2.35559581

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_15608294_ChIP-ChIP_MCF-7_Human4.64577800
2GBX2_23144817_ChIP-Seq_PC3_Human3.73716062
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.70140281
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.51502655
5E2F7_22180533_ChIP-Seq_HELA_Human3.44293264
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21087329
7EZH2_22144423_ChIP-Seq_EOC_Human3.17004846
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.87407126
9AR_21572438_ChIP-Seq_LNCaP_Human2.85165786
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.80290978
11* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.58648129
12TAF15_26573619_Chip-Seq_HEK293_Human2.58568713
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51850203
14ERG_21242973_ChIP-ChIP_JURKAT_Human2.41639710
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.41532438
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36854111
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36445124
18CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.27775416
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.24391961
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20923338
21DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.20235412
22JARID2_20064375_ChIP-Seq_MESCs_Mouse2.16693167
23GABP_19822575_ChIP-Seq_HepG2_Human2.16237020
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.15273412
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11410001
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11252666
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.05792833
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.05185488
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03517841
30CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01901645
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.01835763
32RXR_22158963_ChIP-Seq_LIVER_Mouse2.01289980
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99508617
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99508617
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97579611
36CLOCK_20551151_ChIP-Seq_293T_Human1.93205812
37SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91667713
38IGF1R_20145208_ChIP-Seq_DFB_Human1.89789167
39P300_19829295_ChIP-Seq_ESCs_Human1.89656712
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.88441667
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.87961067
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86440091
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85580616
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81097546
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80708077
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.78456999
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78137065
48MYC_18555785_ChIP-Seq_MESCs_Mouse1.76991154
49EZH2_27294783_Chip-Seq_ESCs_Mouse1.75075674
50TP53_22127205_ChIP-Seq_IMR90_Human1.74218551
51NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.74214688
52ZFP281_18757296_ChIP-ChIP_E14_Mouse1.72282610
53CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.70241570
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.70150306
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.69963534
56SMAD4_21799915_ChIP-Seq_A2780_Human1.68012273
57LXR_22292898_ChIP-Seq_THP-1_Human1.67953808
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.67361107
59PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66507807
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62883476
61PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.62109223
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.60653281
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.59067174
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.58593109
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.57751123
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56973648
67PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.56482672
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56388817
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.55148411
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54600853
71CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52800597
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.51525035
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51212441
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.50000535
75XRN2_22483619_ChIP-Seq_HELA_Human1.49587597
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48797434
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48281516
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.47927605
79RNF2_27304074_Chip-Seq_ESCs_Mouse1.47645802
80FOXP1_21924763_ChIP-Seq_HESCs_Human1.47598751
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47267017
82RARA_24833708_ChIP-Seq_LIVER_Mouse1.47052569
83DROSHA_22980978_ChIP-Seq_HELA_Human1.47025360
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.45564849
85TP53_18474530_ChIP-ChIP_U2OS_Human1.44595083
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44124621
87REST_21632747_ChIP-Seq_MESCs_Mouse1.43978912
88NANOG_18555785_ChIP-Seq_MESCs_Mouse1.42635184
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.42473206
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40631683
91NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39423560
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39343594
93ELF1_20517297_ChIP-Seq_JURKAT_Human1.38266373
94ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37803340
95AR_25329375_ChIP-Seq_VCAP_Human1.37552465
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.36481637
97EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.35956650
98TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34586744
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34357472
100SMAD3_21741376_ChIP-Seq_EPCs_Human1.33985504
101SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33970841
102EGR1_19374776_ChIP-ChIP_THP-1_Human1.33924879
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33591288
104PPARA_22158963_ChIP-Seq_LIVER_Mouse1.32863044
105VDR_22108803_ChIP-Seq_LS180_Human1.30866045
106SMAD_19615063_ChIP-ChIP_OVARY_Human1.30712559
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.30320866
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.30212836
109RNF2_27304074_Chip-Seq_NSC_Mouse1.30069897
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30052093
111P68_20966046_ChIP-Seq_HELA_Human1.29928663
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29065963
113ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28704781
114CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27774279
115SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27670243
116HTT_18923047_ChIP-ChIP_STHdh_Human1.27612013
117ER_23166858_ChIP-Seq_MCF-7_Human1.26813162
118PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26603148
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.26546732
120NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.26546732
121DCP1A_22483619_ChIP-Seq_HELA_Human1.26260570
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26009564
123CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25988100
124PHF8_20622854_ChIP-Seq_HELA_Human1.23782765
125NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23057755
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.22784544
127BCAT_22108803_ChIP-Seq_LS180_Human1.22641011
128MYC_19079543_ChIP-ChIP_MESCs_Mouse1.22397628
129SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21827132
130ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21026446
131NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20698364
132KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20457790
133NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19816072
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19034032
135TTF2_22483619_ChIP-Seq_HELA_Human1.18498183
136RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17633218
137STAT3_23295773_ChIP-Seq_U87_Human1.17508528
138CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16940612
139FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.16531263
140SOX2_21211035_ChIP-Seq_LN229_Gbm1.16387076
141NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15859972
142RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15581031
143ATF3_27146783_Chip-Seq_COLON_Human1.14858347
144REST_18959480_ChIP-ChIP_MESCs_Mouse1.14200516
145ETS1_20019798_ChIP-Seq_JURKAT_Human1.13750403
146KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12973567
147KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12088222
148SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11675611
149YY1_22570637_ChIP-Seq_MALME-3M_Human1.11084190
150SMC3_22415368_ChIP-Seq_MEFs_Mouse1.10919015
151P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10689896
152TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10456764
153CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10165439
154FOXA2_19822575_ChIP-Seq_HepG2_Human1.09336753
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09044956
156IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09011379
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08179736
158MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.07235795
159SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06552634
160DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06104727
161ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05762398
162SMC4_20622854_ChIP-Seq_HELA_Human1.05683698
163RUNX2_22187159_ChIP-Seq_PCA_Human1.05342777
164EZH2_27294783_Chip-Seq_NPCs_Mouse1.05268324
165KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05063570
166POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04695349
167TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04695349
168ELK4_26923725_Chip-Seq_MESODERM_Mouse1.04404032
169RARB_24833708_ChIP-Seq_LIVER_Mouse1.03592092
170NANOG_18555785_Chip-Seq_ESCs_Mouse1.03388625
171ARNT_22903824_ChIP-Seq_MCF-7_Human1.02799902
172TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.02367025
173ZNF274_21170338_ChIP-Seq_K562_Hela1.01487785
174HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01380789
175CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00467940
176TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00273263
177KDM2B_26808549_Chip-Seq_REH_Human1.00182239
178BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99989752
179SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.99951727
180STAT3_1855785_ChIP-Seq_MESCs_Mouse0.99843449
181RXR_22108803_ChIP-Seq_LS180_Human0.99500057
182EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99177195
183JUN_21703547_ChIP-Seq_K562_Human0.98683948
184SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98478021
185UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97807798
186MYC_22102868_ChIP-Seq_BL_Human0.97323358
187PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97313088
188TCF4_23295773_ChIP-Seq_U87_Human0.97295526
189NFE2_27457419_Chip-Seq_LIVER_Mouse0.96389250
190MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96176201
191AHR_22903824_ChIP-Seq_MCF-7_Human0.94808132
192CIITA_25753668_ChIP-Seq_RAJI_Human0.94758089
193TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93718082
194MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93547948
195P53_22387025_ChIP-Seq_ESCs_Mouse0.93338108
196E2F1_18555785_Chip-Seq_ESCs_Mouse0.93088165

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.07211329
2MP0008875_abnormal_xenobiotic_pharmacok3.68194446
3MP0005360_urolithiasis3.58066710
4MP0005365_abnormal_bile_salt3.39354155
5MP0005085_abnormal_gallbladder_physiolo3.38633935
6MP0005058_abnormal_lysosome_morphology3.09288391
7MP0010030_abnormal_orbit_morphology2.90521207
8MP0001849_ear_inflammation2.89867994
9MP0000537_abnormal_urethra_morphology2.75239635
10MP0003172_abnormal_lysosome_physiology2.69525418
11MP0004859_abnormal_synaptic_plasticity2.68785949
12MP0003880_abnormal_central_pattern2.62637943
13MP0005646_abnormal_pituitary_gland2.57927257
14MP0000003_abnormal_adipose_tissue2.46455253
15MP0008438_abnormal_cutaneous_collagen2.43396873
16MP0004185_abnormal_adipocyte_glucose2.42640502
17MP0002822_catalepsy2.36835027
18MP0001968_abnormal_touch/_nociception2.28402109
19MP0006276_abnormal_autonomic_nervous2.26744660
20MP0003136_yellow_coat_color2.24029743
21MP0009745_abnormal_behavioral_response2.23414599
22MP0003705_abnormal_hypodermis_morpholog2.20282369
23MP0003635_abnormal_synaptic_transmissio2.18738912
24MP0001299_abnormal_eye_distance/2.13350752
25MP0001501_abnormal_sleep_pattern2.08888065
26MP0001984_abnormal_olfaction2.06810868
27MP0002064_seizures2.05382757
28MP0003111_abnormal_nucleus_morphology2.03533710
29MP0002009_preneoplasia2.01679142
30MP0005645_abnormal_hypothalamus_physiol1.98834957
31MP0002736_abnormal_nociception_after1.95739241
32MP0002572_abnormal_emotion/affect_behav1.95031431
33MP0005666_abnormal_adipose_tissue1.95004293
34MP0001486_abnormal_startle_reflex1.91873713
35MP0000013_abnormal_adipose_tissue1.87860735
36MP0002063_abnormal_learning/memory/cond1.86899446
37MP0003122_maternal_imprinting1.84527090
38MP0009046_muscle_twitch1.83911784
39MP0002734_abnormal_mechanical_nocicepti1.79453776
40MP0002876_abnormal_thyroid_physiology1.78123595
41MP0001986_abnormal_taste_sensitivity1.77545257
42MP0003950_abnormal_plasma_membrane1.74359328
43MP0010368_abnormal_lymphatic_system1.73260127
44MP0002272_abnormal_nervous_system1.69419607
45MP0010329_abnormal_lipoprotein_level1.68333354
46MP0003690_abnormal_glial_cell1.67202536
47MP0005332_abnormal_amino_acid1.63712293
48MP0000372_irregular_coat_pigmentation1.63542141
49MP0000534_abnormal_ureter_morphology1.61419024
50MP0008260_abnormal_autophagy1.61101769
51MP0004142_abnormal_muscle_tone1.60941656
52MP0005257_abnormal_intraocular_pressure1.58381729
53MP0009384_cardiac_valve_regurgitation1.57905754
54MP0001958_emphysema1.55268294
55MP0002837_dystrophic_cardiac_calcinosis1.54869399
56MP0003252_abnormal_bile_duct1.52737567
57MP0003566_abnormal_cell_adhesion1.51467242
58MP0001440_abnormal_grooming_behavior1.47601339
59MP0000733_abnormal_muscle_development1.46673872
60MP0005375_adipose_tissue_phenotype1.45777440
61MP0008007_abnormal_cellular_replicative1.44419432
62MP0003942_abnormal_urinary_system1.43786006
63MP0002638_abnormal_pupillary_reflex1.42391916
64MP0010307_abnormal_tumor_latency1.41978886
65MP0005023_abnormal_wound_healing1.41307053
66MP0004270_analgesia1.40496265
67MP0001502_abnormal_circadian_rhythm1.39764020
68MP0000767_abnormal_smooth_muscle1.38751904
69MP0009697_abnormal_copulation1.38422598
70MP0002254_reproductive_system_inflammat1.35294778
71MP0004019_abnormal_vitamin_homeostasis1.34986189
72MP0001853_heart_inflammation1.29914835
73MP0004272_abnormal_basement_membrane1.29122301
74MP0002735_abnormal_chemical_nociception1.28062338
75MP0002557_abnormal_social/conspecific_i1.26381354
76MP0003786_premature_aging1.26317969
77MP0003329_amyloid_beta_deposits1.24170973
78MP0002089_abnormal_postnatal_growth/wei1.24135889
79MP0002184_abnormal_innervation1.23692617
80MP0003385_abnormal_body_wall1.23439680
81MP0009250_abnormal_appendicular_skeleto1.22937227
82MP0001270_distended_abdomen1.22366028
83MP0001529_abnormal_vocalization1.21592852
84MP0003279_aneurysm1.20934905
85MP0002067_abnormal_sensory_capabilities1.20612606
86MP0001666_abnormal_nutrient_absorption1.20234044
87MP0000566_synostosis1.16451636
88MP0003195_calcinosis1.15561722
89MP0002396_abnormal_hematopoietic_system1.13479025
90MP0005076_abnormal_cell_differentiation1.13300948
91MP0000538_abnormal_urinary_bladder1.12642459
92MP0002938_white_spotting1.12319032
93MP0002877_abnormal_melanocyte_morpholog1.11013558
94MP0000858_altered_metastatic_potential1.10689891
95MP0005535_abnormal_body_temperature1.09539083
96MP0001764_abnormal_homeostasis1.09334450
97MP0000778_abnormal_nervous_system1.09196042
98MP0001970_abnormal_pain_threshold1.06649315
99MP0003937_abnormal_limbs/digits/tail_de1.06197414
100MP0001730_embryonic_growth_arrest1.05174055
101MP0005423_abnormal_somatic_nervous1.05005876
102MP0010094_abnormal_chromosome_stability1.03749871
103MP0000428_abnormal_craniofacial_morphol1.03598719
104MP0002118_abnormal_lipid_homeostasis1.02927564
105MP0001177_atelectasis1.00425834
106MP0004130_abnormal_muscle_cell0.99663731
107MP0000751_myopathy0.99100175
108MP0002909_abnormal_adrenal_gland0.99015674
109MP0000604_amyloidosis0.98672934
110MP0003115_abnormal_respiratory_system0.98503290
111MP0002733_abnormal_thermal_nociception0.98288454
112MP0002116_abnormal_craniofacial_bone0.98217303
113MP0002933_joint_inflammation0.98082731
114MP0008872_abnormal_physiological_respon0.97496833
115MP0004381_abnormal_hair_follicle0.96829806
116MP0006292_abnormal_olfactory_placode0.96821004
117MP0002925_abnormal_cardiovascular_devel0.96391136
118MP0001905_abnormal_dopamine_level0.95648083
119MP0000230_abnormal_systemic_arterial0.94940116
120MP0006138_congestive_heart_failure0.94595623
121MP0002114_abnormal_axial_skeleton0.94327682
122MP0004858_abnormal_nervous_system0.93581341
123MP0005083_abnormal_biliary_tract0.92802101
124MP0006054_spinal_hemorrhage0.91670351
125MP0003633_abnormal_nervous_system0.91645753
126MP0000358_abnormal_cell_content/0.91070358
127MP0008789_abnormal_olfactory_epithelium0.90843371
128MP0008569_lethality_at_weaning0.90780838
129MP0003868_abnormal_feces_composition0.90756973
130MP0005551_abnormal_eye_electrophysiolog0.90374855
131MP0004924_abnormal_behavior0.90217424
132MP0005386_behavior/neurological_phenoty0.90217424
133MP0010386_abnormal_urinary_bladder0.90206540
134MP0002233_abnormal_nose_morphology0.90084111
135MP0005409_darkened_coat_color0.89685087
136MP0003119_abnormal_digestive_system0.89011753
137MP0004085_abnormal_heartbeat0.88592218
138MP0004742_abnormal_vestibular_system0.87465734
139MP0004197_abnormal_fetal_growth/weight/0.87016903
140MP0004885_abnormal_endolymph0.86916557
141MP0009840_abnormal_foam_cell0.86665670
142MP0002751_abnormal_autonomic_nervous0.84818313
143MP0004883_abnormal_blood_vessel0.84443695
144MP0002086_abnormal_extraembryonic_tissu0.84238346
145MP0003879_abnormal_hair_cell0.83921687
146MP0003077_abnormal_cell_cycle0.82344879
147MP0005503_abnormal_tendon_morphology0.81668411
148MP0008874_decreased_physiological_sensi0.81582039
149MP0003935_abnormal_craniofacial_develop0.81400839
150MP0002128_abnormal_blood_circulation0.80996621
151MP0005595_abnormal_vascular_smooth0.79630551
152MP0000678_abnormal_parathyroid_gland0.79334823
153MP0002066_abnormal_motor_capabilities/c0.79096416
154MP0000639_abnormal_adrenal_gland0.78750129
155MP0002084_abnormal_developmental_patter0.78601954
156MP0005499_abnormal_olfactory_system0.78171252
157MP0005394_taste/olfaction_phenotype0.78171252
158MP0001915_intracranial_hemorrhage0.77577981
159MP0003693_abnormal_embryo_hatching0.76969360
160MP0004084_abnormal_cardiac_muscle0.76634365
161MP0001661_extended_life_span0.76177246
162MP0002080_prenatal_lethality0.75924192
163MP0001348_abnormal_lacrimal_gland0.75900694
164MP0005584_abnormal_enzyme/coenzyme_acti0.75245163
165MP0003878_abnormal_ear_physiology0.74262401
166MP0005377_hearing/vestibular/ear_phenot0.74262401
167MP0002295_abnormal_pulmonary_circulatio0.74061806
168MP0004957_abnormal_blastocyst_morpholog0.73957027
169MP0005379_endocrine/exocrine_gland_phen0.73623282
170MP0001614_abnormal_blood_vessel0.73591350
171MP0001542_abnormal_bone_strength0.72634155
172MP0004087_abnormal_muscle_fiber0.72505489
173MP0003186_abnormal_redox_activity0.72391096
174MP0003656_abnormal_erythrocyte_physiolo0.72284321
175MP0005380_embryogenesis_phenotype0.72147237
176MP0001672_abnormal_embryogenesis/_devel0.72147237
177MP0001188_hyperpigmentation0.71529185
178MP0002085_abnormal_embryonic_tissue0.71323771
179MP0000759_abnormal_skeletal_muscle0.71090560
180MP0000462_abnormal_digestive_system0.71078740
181MP0003984_embryonic_growth_retardation0.70747073
182MP0010630_abnormal_cardiac_muscle0.68798848
183MP0002882_abnormal_neuron_morphology0.68256311
184MP0000749_muscle_degeneration0.68194379
185MP0000955_abnormal_spinal_cord0.67747642
186MP0008932_abnormal_embryonic_tissue0.66921830
187MP0001697_abnormal_embryo_size0.65826810

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)6.30953993
2Biconcave vertebral bodies (HP:0004586)5.40564491
3Protrusio acetabuli (HP:0003179)5.35131870
4Abnormality of aromatic amino acid family metabolism (HP:0004338)4.71931308
5Broad face (HP:0000283)4.62373126
6Focal motor seizures (HP:0011153)4.62147248
7J-shaped sella turcica (HP:0002680)4.13845893
8Prolonged partial thromboplastin time (HP:0003645)3.99192908
9Premature rupture of membranes (HP:0001788)3.94814048
10Intrahepatic cholestasis (HP:0001406)3.89218589
11Deep venous thrombosis (HP:0002625)3.80347243
12Flat acetabular roof (HP:0003180)3.77784123
13Hypobetalipoproteinemia (HP:0003563)3.66583792
14Hyperventilation (HP:0002883)3.61331181
15Hyperlipoproteinemia (HP:0010980)3.52075347
16Spinal cord lesions (HP:0100561)3.50249508
17Syringomyelia (HP:0003396)3.50249508
18Xanthomatosis (HP:0000991)3.49743457
19Mucopolysacchariduria (HP:0008155)3.44398146
20Urinary glycosaminoglycan excretion (HP:0003541)3.44398146
21Spontaneous abortion (HP:0005268)3.33584600
22Entropion (HP:0000621)3.31276368
23Exercise-induced myalgia (HP:0003738)3.30312639
24Menorrhagia (HP:0000132)3.27668926
25Flared iliac wings (HP:0002869)3.26242303
26Osteomalacia (HP:0002749)3.23808433
27Aortic regurgitation (HP:0001659)3.17968589
28Joint stiffness (HP:0001387)3.16696876
29Wide nose (HP:0000445)3.15489489
30Short nail (HP:0001799)3.13403466
31Abnormality of polysaccharide metabolism (HP:0011012)3.11801243
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.11801243
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.11801243
34Thin bony cortex (HP:0002753)3.11195524
35Vascular calcification (HP:0004934)3.08513328
36Abnormality of monocarboxylic acid metabolism (HP:0010996)3.04621023
37Submucous cleft hard palate (HP:0000176)2.97950476
38Enlarged kidneys (HP:0000105)2.96117123
39Dysostosis multiplex (HP:0000943)2.94810770
40Stridor (HP:0010307)2.94008067
41Hypolipoproteinemia (HP:0010981)2.92653490
42Abnormality of dentin (HP:0010299)2.91009465
43Joint hemorrhage (HP:0005261)2.90285208
44Focal seizures (HP:0007359)2.87666950
45Scanning speech (HP:0002168)2.87394416
46Abnormality of the acetabulum (HP:0003170)2.76763540
47Fair hair (HP:0002286)2.72988912
48Hypoalphalipoproteinemia (HP:0003233)2.71562754
49Neurofibrillary tangles (HP:0002185)2.71136237
50Blue irides (HP:0000635)2.69762142
51Cardiovascular calcification (HP:0011915)2.67424319
52Epileptic encephalopathy (HP:0200134)2.65312062
53Febrile seizures (HP:0002373)2.63165382
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.62269134
55Short clavicles (HP:0000894)2.56438427
56Selective tooth agenesis (HP:0001592)2.56106411
57Chronic hepatic failure (HP:0100626)2.55265769
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.54381242
59Complement deficiency (HP:0004431)2.53560089
60Atonic seizures (HP:0010819)2.52919970
61Vertebral compression fractures (HP:0002953)2.49009319
62Wormian bones (HP:0002645)2.47001871
63Ulnar bowing (HP:0003031)2.46876389
64Conjugated hyperbilirubinemia (HP:0002908)2.46584150
65Tracheal stenosis (HP:0002777)2.43911891
66Poor suck (HP:0002033)2.43853049
67Nuclear cataract (HP:0100018)2.43121016
68Distal lower limb amyotrophy (HP:0008944)2.41910960
69Short tibia (HP:0005736)2.40414251
70Hypothermia (HP:0002045)2.39630732
71Symptomatic seizures (HP:0011145)2.39494360
72Obstructive sleep apnea (HP:0002870)2.38844175
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.37332444
74Deformed sella turcica (HP:0002681)2.36188032
75Turricephaly (HP:0000262)2.34633848
76Difficulty climbing stairs (HP:0003551)2.34148099
77Aortic aneurysm (HP:0004942)2.33252276
78Ketosis (HP:0001946)2.32237793
79Aortic dissection (HP:0002647)2.28954738
80Amyloidosis (HP:0011034)2.28529807
81Mitral regurgitation (HP:0001653)2.26879410
82Decreased central vision (HP:0007663)2.25854558
83Polyphagia (HP:0002591)2.25307096
84Hip contracture (HP:0003273)2.23614790
85Occipital encephalocele (HP:0002085)2.23047267
86Shallow orbits (HP:0000586)2.21910379
87Dislocated radial head (HP:0003083)2.20516540
88Hypophosphatemic rickets (HP:0004912)2.20457458
89Long toe (HP:0010511)2.18579604
90Severe muscular hypotonia (HP:0006829)2.17537143
91Bell-shaped thorax (HP:0001591)2.16447168
92Generalized tonic-clonic seizures (HP:0002069)2.14805713
93Abnormality of the common coagulation pathway (HP:0010990)2.14279827
94Cerebral aneurysm (HP:0004944)2.13605726
95Generalized hypopigmentation of hair (HP:0011358)2.13482913
96Delayed CNS myelination (HP:0002188)2.13329554
97Abnormality of carpal bone ossification (HP:0006257)2.12905411
98Aplasia/Hypoplasia of the clavicles (HP:0006710)2.12679113
99Absence seizures (HP:0002121)2.09733522
10011 pairs of ribs (HP:0000878)2.08566827
101Optic nerve coloboma (HP:0000588)2.06674252
102Abnormality of renal resorption (HP:0011038)2.06193530
103Arterial tortuosity (HP:0005116)2.06151396
104Status epilepticus (HP:0002133)2.05988360
105Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.04992232
106Medial flaring of the eyebrow (HP:0010747)2.04750761
107Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04322458
108Abnormality of the distal phalanges of the toes (HP:0010182)2.03997800
109Abnormal ossification of hand bones (HP:0005921)2.02589718
110Nasal speech (HP:0001611)2.00929426
111Abnormality of sulfur amino acid metabolism (HP:0004339)2.00061763
112Broad palm (HP:0001169)1.99698159
113Epidermoid cyst (HP:0200040)1.98954551
114Ketoacidosis (HP:0001993)1.98803642
115Epiphyseal stippling (HP:0010655)1.98472048
116Male infertility (HP:0003251)1.97569795
117Interstitial pulmonary disease (HP:0006530)1.97324458
118Hypoplasia of the fovea (HP:0007750)1.96888185
119Aplasia/Hypoplasia of the fovea (HP:0008060)1.96888185
120Abnormality of the radial head (HP:0003995)1.96677469
121Asymmetry of the thorax (HP:0001555)1.95976508
122Renal Fanconi syndrome (HP:0001994)1.94948647
123Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.94580724
124Metaphyseal cupping (HP:0003021)1.94157832
125Aplasia of the phalanges of the hand (HP:0009802)1.93945091
126Aplasia involving bones of the extremities (HP:0009825)1.93945091
127Aplasia involving bones of the upper limbs (HP:0009823)1.93945091
128Gait imbalance (HP:0002141)1.93622859
129Anxiety (HP:0000739)1.93045861
130Abnormality of the Achilles tendon (HP:0005109)1.92268557
131Dialeptic seizures (HP:0011146)1.92251191
132Cupped ribs (HP:0000887)1.91807486
133Abnormality of methionine metabolism (HP:0010901)1.91700373
134Hyperglycinuria (HP:0003108)1.91416244
135Fat malabsorption (HP:0002630)1.90290671
136Camptodactyly of toe (HP:0001836)1.90248188
137Myokymia (HP:0002411)1.89998804
138Cerebral inclusion bodies (HP:0100314)1.89844272
139Parakeratosis (HP:0001036)1.89702501
140Renal cortical cysts (HP:0000803)1.89088160
141Hypoglycemic seizures (HP:0002173)1.88784444
142Microvesicular hepatic steatosis (HP:0001414)1.88497561
143Abnormality of aspartate family amino acid metabolism (HP:0010899)1.88209615
144EEG with generalized epileptiform discharges (HP:0011198)1.87709051
145Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87653144
146Epileptiform EEG discharges (HP:0011182)1.87330035
147Distal upper limb amyotrophy (HP:0007149)1.86585239
148Upper limb amyotrophy (HP:0009129)1.86585239
149Recurrent corneal erosions (HP:0000495)1.86478350
150Abnormal hair whorl (HP:0010721)1.83849684
151Femoral bowing (HP:0002980)1.83723972
152Impaired social interactions (HP:0000735)1.83400153
153Abnormal social behavior (HP:0012433)1.83400153
154Hypoplasia of the odontoid process (HP:0003311)1.82877868
155Abnormality of skull ossification (HP:0002703)1.82747062
156Limited hip movement (HP:0008800)1.82271702
157Abnormality of complement system (HP:0005339)1.81709246
158Heterotopia (HP:0002282)1.81457516
159Lymphangioma (HP:0100764)1.80564063
160Rickets (HP:0002748)1.79984825
161Hypsarrhythmia (HP:0002521)1.79880314
162Abnormality of the umbilical cord (HP:0010881)1.79193651
163Hypercholesterolemia (HP:0003124)1.79108084
164Rhizomelia (HP:0008905)1.78597967
165Muscle stiffness (HP:0003552)1.78439592
166Broad alveolar ridges (HP:0000187)1.78028647
167Achilles tendon contracture (HP:0001771)1.78011319
168Poor eye contact (HP:0000817)1.77916922
169Vertebral hypoplasia (HP:0008417)1.77432206
170Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.77432206
171Abnormality of serine family amino acid metabolism (HP:0010894)1.76983426
172Abnormality of glycine metabolism (HP:0010895)1.76983426
173Hypoplastic pelvis (HP:0008839)1.76953132
174Decreased subcutaneous fat (HP:0001002)1.75792948
175Abnormality of the odontoid process (HP:0003310)1.75720954
176Absent speech (HP:0001344)1.75063285
177Sleep apnea (HP:0010535)1.75052831
178Abnormal hair laboratory examination (HP:0003328)1.74933937
179Hyperammonemia (HP:0001987)1.74374301
180Abnormality of the sella turcica (HP:0002679)1.74263653
181Hyperglycinemia (HP:0002154)1.73916806
182Mitral stenosis (HP:0001718)1.73761292
183Abnormality of the intrinsic pathway (HP:0010989)1.73751356
184Abnormality of the lower motor neuron (HP:0002366)1.73472608
185Skin nodule (HP:0200036)1.72952570
186Absent epiphyses (HP:0010577)1.72540690
187Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72540690
188Blue sclerae (HP:0000592)1.71943166
189Cerebral edema (HP:0002181)1.71441126
190Congenital primary aphakia (HP:0007707)1.71309327
191Abnormal eating behavior (HP:0100738)1.67433435
192Poor speech (HP:0002465)1.66056028
193Abnormality of the fovea (HP:0000493)1.65972922
194Gaze-evoked nystagmus (HP:0000640)1.65712750
195Brushfield spots (HP:0001088)1.64715209
196Progressive cerebellar ataxia (HP:0002073)1.64532639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA35.54795595
2MAP2K35.50641250
3TRIB34.96539229
4CASK4.44088032
5MAP2K63.66790879
6NTRK32.99599690
7MAP3K122.97999342
8ZAK2.83048129
9TNIK2.82961934
10EPHA42.74470396
11PTK22.65854496
12DYRK1A2.43346888
13ICK2.36444739
14MAP2K42.30944302
15WNK12.18535739
16PDK22.09503388
17MAP3K42.08320437
18MAP3K132.06523458
19MAP2K72.04836232
20FRK1.92748258
21NTRK11.86572372
22EEF2K1.86567031
23PKN21.80488668
24WNK41.76923639
25MAP3K91.73197722
26AKT31.68548336
27PINK11.59456424
28INSRR1.50985918
29FGFR21.49300682
30SGK21.46548519
31MST1R1.46527774
32MAPK131.45815482
33MARK11.44689508
34TTN1.43873689
35PBK1.43637616
36CDK121.41307336
37SRPK11.39514241
38TNK21.31729467
39ZAP701.28566740
40PDGFRB1.28041164
41BRSK11.27395057
42SGK4941.23770648
43SGK2231.23770648
44TXK1.21585444
45MAPK121.21498959
46MINK11.20054775
47PTK2B1.19632001
48FGFR31.18025306
49SIK31.16165722
50ERBB41.14670497
51JAK31.12344366
52MET1.09981645
53ARAF1.09561194
54PIK3CG1.09185694
55LATS21.09130785
56NTRK21.08254538
57PLK21.01740615
58MAP3K101.00106890
59MKNK20.96912403
60PRKCG0.95631143
61CDK80.92686524
62BRAF0.92063313
63BMPR20.91874684
64IRAK30.91634271
65TYRO30.91505287
66GRK70.90653833
67TAOK30.89127064
68ADRBK20.88396642
69MAP3K70.87416916
70LATS10.85653822
71CDK90.83082452
72CAMK2A0.82836488
73PRKCE0.82766178
74FGFR10.81738087
75FLT30.80970864
76PAK60.76879514
77EPHB10.76510595
78RIPK10.75802482
79DDR20.75719966
80PRPF4B0.75561377
81PIK3CA0.74492965
82PAK20.74453341
83BCKDK0.73875215
84MTOR0.72899593
85CDK50.72700057
86DAPK20.71731960
87MAP3K30.70920147
88SMG10.70411247
89PHKG20.69231520
90PHKG10.69231520
91SGK30.67210586
92SIK10.67154424
93PDPK10.65230297
94KSR10.65118016
95NUAK10.64966032
96SIK20.64861133
97CAMK2G0.64847436
98PAK40.63946228
99CDK70.63395986
100FGFR40.63168562
101MAP3K140.60887823
102MAP3K20.60603240
103PAK30.59963170
104CAMK2B0.59327824
105DYRK1B0.58832025
106PKN10.58637025
107MAPKAPK50.58574680
108WNK30.56010062
109FES0.54801023
110ERN10.54703421
111EPHA20.54596610
112PRKCH0.54433011
113KSR20.54283924
114MAPK110.54219940
115OXSR10.54153271
116RET0.54028934
117BUB10.53806549
118YES10.52317457
119CDK30.52150895
120EPHB20.51718665
121IRAK10.51568326
122CAMK2D0.50659558
123PTK60.50447349
124CAMK10.48689266
125STK380.48422132
126MOS0.47868816
127TTK0.47454869
128RAF10.45954328
129BRD40.45664242
130NEK60.45645203
131ATR0.45468543
132PDK10.45462022
133MAP2K10.45275437
134MELK0.45088122
135MAP3K110.44574927
136CHEK20.43910151
137CDC42BPA0.42569649
138LMTK20.42111528
139CDK40.42003687
140MAPK70.41756341
141PDGFRA0.41732164
142STK38L0.41212053
143NEK90.39753432
144CHEK10.39673882
145BMPR1B0.38788480
146NEK20.38090230
147RPS6KA20.37309295
148SGK10.35848065
149BCR0.35579557
150MAP3K60.35195034
151CAMKK10.35141957
152CSNK1A1L0.35116140
153PRKAA20.35076579
154RIPK40.35024662
155PRKD30.34816212
156MAPK150.34779035
157ERBB30.33527048
158RPS6KL10.33016039
159RPS6KC10.33016039
160PRKD20.32287508
161GRK60.31023005
162ILK0.30833549
163ERBB20.30438541
164WEE10.29838456
165BRSK20.29332956
166FGR0.28901779
167CSNK1D0.28298749
168CDK20.27894170
169CDK10.24872614
170MAPK10.23921568
171MARK20.23402918
172CDK150.22822614
173PNCK0.22741838
174AKT20.22085543
175MAPK80.20723849
176CDK11A0.19527720
177RPS6KA60.19197770

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005115.13625403
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.18535222
3Nicotine addiction_Homo sapiens_hsa050332.80221853
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.76036239
5Butanoate metabolism_Homo sapiens_hsa006502.65653376
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.33192151
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.27761255
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19674563
9Nitrogen metabolism_Homo sapiens_hsa009102.15713252
10Arginine biosynthesis_Homo sapiens_hsa002202.09890374
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08617170
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02556753
13Chemical carcinogenesis_Homo sapiens_hsa052042.01428779
14Sulfur metabolism_Homo sapiens_hsa009201.99119133
15mRNA surveillance pathway_Homo sapiens_hsa030151.84599055
16Complement and coagulation cascades_Homo sapiens_hsa046101.84522187
17Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83166663
18VEGF signaling pathway_Homo sapiens_hsa043701.79732201
19ECM-receptor interaction_Homo sapiens_hsa045121.79259013
20AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.78146626
21GABAergic synapse_Homo sapiens_hsa047271.77123477
22Tryptophan metabolism_Homo sapiens_hsa003801.67473205
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.66255230
24beta-Alanine metabolism_Homo sapiens_hsa004101.61453941
25p53 signaling pathway_Homo sapiens_hsa041151.59201905
26Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.55568946
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.52175425
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50794161
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.49985666
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48468799
31Histidine metabolism_Homo sapiens_hsa003401.47779408
32Synaptic vesicle cycle_Homo sapiens_hsa047211.47047867
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.40255059
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38965136
35Small cell lung cancer_Homo sapiens_hsa052221.38665967
36Peroxisome_Homo sapiens_hsa041461.38376189
37Spliceosome_Homo sapiens_hsa030401.36239493
38mTOR signaling pathway_Homo sapiens_hsa041501.36154198
39Base excision repair_Homo sapiens_hsa034101.35479241
40Morphine addiction_Homo sapiens_hsa050321.32851829
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32727611
42Taste transduction_Homo sapiens_hsa047421.30005512
43Phenylalanine metabolism_Homo sapiens_hsa003601.29022372
44Fatty acid degradation_Homo sapiens_hsa000711.27729716
45Lysine degradation_Homo sapiens_hsa003101.26860250
46Glutamatergic synapse_Homo sapiens_hsa047241.25364865
47Biosynthesis of amino acids_Homo sapiens_hsa012301.24489467
48Bile secretion_Homo sapiens_hsa049761.23408550
49N-Glycan biosynthesis_Homo sapiens_hsa005101.22799940
50Adipocytokine signaling pathway_Homo sapiens_hsa049201.18714339
51DNA replication_Homo sapiens_hsa030301.18680719
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17685004
53Olfactory transduction_Homo sapiens_hsa047401.17030249
54Fatty acid elongation_Homo sapiens_hsa000621.16999112
55Focal adhesion_Homo sapiens_hsa045101.15881908
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12693324
57Nucleotide excision repair_Homo sapiens_hsa034201.10369976
58Serotonergic synapse_Homo sapiens_hsa047261.09516999
59RNA transport_Homo sapiens_hsa030131.06348649
60Fanconi anemia pathway_Homo sapiens_hsa034601.06306720
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06126351
62Non-small cell lung cancer_Homo sapiens_hsa052231.05792676
63Propanoate metabolism_Homo sapiens_hsa006401.05058066
64Retinol metabolism_Homo sapiens_hsa008301.04072263
65ABC transporters_Homo sapiens_hsa020101.03247303
66Collecting duct acid secretion_Homo sapiens_hsa049661.02445276
67Cell cycle_Homo sapiens_hsa041101.02188202
68Prolactin signaling pathway_Homo sapiens_hsa049171.00639735
69RNA degradation_Homo sapiens_hsa030181.00597581
70Glioma_Homo sapiens_hsa052140.99152940
71Fatty acid metabolism_Homo sapiens_hsa012120.98419129
72Circadian entrainment_Homo sapiens_hsa047130.97729006
73Staphylococcus aureus infection_Homo sapiens_hsa051500.96730911
74Steroid biosynthesis_Homo sapiens_hsa001000.96683679
75Tyrosine metabolism_Homo sapiens_hsa003500.96491100
76Non-homologous end-joining_Homo sapiens_hsa034500.95998502
77PPAR signaling pathway_Homo sapiens_hsa033200.95994019
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.95975779
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.95536288
80Starch and sucrose metabolism_Homo sapiens_hsa005000.93981482
81Chronic myeloid leukemia_Homo sapiens_hsa052200.93745258
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93331076
83Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92996671
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92798007
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91420824
86TGF-beta signaling pathway_Homo sapiens_hsa043500.90415380
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89433899
88Hippo signaling pathway_Homo sapiens_hsa043900.89382540
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.87399659
90Fructose and mannose metabolism_Homo sapiens_hsa000510.86684131
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85306823
92Caffeine metabolism_Homo sapiens_hsa002320.83031953
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82445350
94Shigellosis_Homo sapiens_hsa051310.81389075
95Proteoglycans in cancer_Homo sapiens_hsa052050.79123390
96Insulin secretion_Homo sapiens_hsa049110.78278355
97Salivary secretion_Homo sapiens_hsa049700.75291092
98MicroRNAs in cancer_Homo sapiens_hsa052060.73951122
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73543311
100Long-term potentiation_Homo sapiens_hsa047200.73501678
101Bladder cancer_Homo sapiens_hsa052190.72921225
102Glucagon signaling pathway_Homo sapiens_hsa049220.72864462
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71945427
104Amphetamine addiction_Homo sapiens_hsa050310.71409169
105Renin-angiotensin system_Homo sapiens_hsa046140.71126491
106Long-term depression_Homo sapiens_hsa047300.69880213
107Calcium signaling pathway_Homo sapiens_hsa040200.68917777
108Choline metabolism in cancer_Homo sapiens_hsa052310.68760108
109Notch signaling pathway_Homo sapiens_hsa043300.68223294
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68072960
111Pyruvate metabolism_Homo sapiens_hsa006200.67484355
112Arginine and proline metabolism_Homo sapiens_hsa003300.65185836
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.65136720
114Oxidative phosphorylation_Homo sapiens_hsa001900.63965473
115Dopaminergic synapse_Homo sapiens_hsa047280.63613286
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.63521175
117Cocaine addiction_Homo sapiens_hsa050300.63106824
118Cholinergic synapse_Homo sapiens_hsa047250.62756627
119PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62669529
120Insulin signaling pathway_Homo sapiens_hsa049100.62252300
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61988860
122Prion diseases_Homo sapiens_hsa050200.61349409
123Renin secretion_Homo sapiens_hsa049240.60800863
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.60638384
125Hedgehog signaling pathway_Homo sapiens_hsa043400.60153128
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59853374
127AMPK signaling pathway_Homo sapiens_hsa041520.59842320
128HIF-1 signaling pathway_Homo sapiens_hsa040660.59144206
129Homologous recombination_Homo sapiens_hsa034400.58320224
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.57916581
131Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56881241
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56579379
133Axon guidance_Homo sapiens_hsa043600.56117067
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.56097669
135Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55497531
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55004204
137Galactose metabolism_Homo sapiens_hsa000520.54432592
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53154997
139Vibrio cholerae infection_Homo sapiens_hsa051100.52798844
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52724051
141One carbon pool by folate_Homo sapiens_hsa006700.52497139
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.52444103
143Inositol phosphate metabolism_Homo sapiens_hsa005620.51264829
144FoxO signaling pathway_Homo sapiens_hsa040680.50751236
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50425658
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48967779
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.48860256
148Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48670312
149Basal transcription factors_Homo sapiens_hsa030220.48376945
150Vitamin B6 metabolism_Homo sapiens_hsa007500.48061562
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46766446
152Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45094423
153Pyrimidine metabolism_Homo sapiens_hsa002400.44553510
154Alzheimers disease_Homo sapiens_hsa050100.44260992
155ErbB signaling pathway_Homo sapiens_hsa040120.44074995
156Oocyte meiosis_Homo sapiens_hsa041140.43689519
157Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43641530
158Circadian rhythm_Homo sapiens_hsa047100.43574064
159Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.43432205
160Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43215966
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40892019
162Adherens junction_Homo sapiens_hsa045200.40878413
163Regulation of autophagy_Homo sapiens_hsa041400.40744324
164cAMP signaling pathway_Homo sapiens_hsa040240.34332672
165Gastric acid secretion_Homo sapiens_hsa049710.33846180
166Metabolic pathways_Homo sapiens_hsa011000.31962816
167Glycerolipid metabolism_Homo sapiens_hsa005610.31665312
168Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30901857
169Sulfur relay system_Homo sapiens_hsa041220.30714973
170Vitamin digestion and absorption_Homo sapiens_hsa049770.29302836
171Phototransduction_Homo sapiens_hsa047440.28886502
172Ovarian steroidogenesis_Homo sapiens_hsa049130.27080412
173Arachidonic acid metabolism_Homo sapiens_hsa005900.26497788
174Glycosaminoglycan degradation_Homo sapiens_hsa005310.26010875
175Fat digestion and absorption_Homo sapiens_hsa049750.25837306
176GnRH signaling pathway_Homo sapiens_hsa049120.25736398
177Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24731795

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »