FBXL22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family. This F-box protein interacts with S-phase kinase-associated protein 1A and cullin in order to form SCF complexes which function as ubiquitin ligases. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.77730755
2sarcomere organization (GO:0045214)7.52126112
3myofibril assembly (GO:0030239)6.86588218
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.85805301
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.18760854
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.05199878
7negative regulation of potassium ion transmembrane transport (GO:1901380)6.04951492
8muscle filament sliding (GO:0030049)6.03423846
9actin-myosin filament sliding (GO:0033275)6.03423846
10ATP synthesis coupled proton transport (GO:0015986)5.89887415
11energy coupled proton transport, down electrochemical gradient (GO:0015985)5.89887415
12cardiac muscle contraction (GO:0060048)5.85592847
13regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.84940328
14cardiac muscle cell development (GO:0055013)5.59522045
15adult heart development (GO:0007512)5.49317360
16respiratory electron transport chain (GO:0022904)5.49168401
17cardiac muscle tissue morphogenesis (GO:0055008)5.47646268
18regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.46810440
19regulation of actin filament-based movement (GO:1903115)5.43517898
20ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.39570439
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.39092579
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.38778974
23regulation of relaxation of muscle (GO:1901077)5.37370132
24regulation of sarcomere organization (GO:0060297)5.37151677
25electron transport chain (GO:0022900)5.34963404
26cardiac cell development (GO:0055006)5.25075599
27actin-mediated cell contraction (GO:0070252)5.24497868
28muscle tissue morphogenesis (GO:0060415)4.94476159
29ventricular cardiac muscle cell action potential (GO:0086005)4.94382674
30negative regulation of protein localization to cell surface (GO:2000009)4.86727799
31actomyosin structure organization (GO:0031032)4.85564322
32heart contraction (GO:0060047)4.78946693
33heart process (GO:0003015)4.78946693
34regulation of cell communication by electrical coupling (GO:0010649)4.75955721
35regulation of striated muscle contraction (GO:0006942)4.69077581
36regulation of the force of heart contraction (GO:0002026)4.65917267
37regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.58023035
38cardiac muscle hypertrophy (GO:0003300)4.57263245
39heart trabecula formation (GO:0060347)4.55946600
40bundle of His cell to Purkinje myocyte communication (GO:0086069)4.54472558
41striated muscle contraction (GO:0006941)4.42127164
42urinary tract smooth muscle contraction (GO:0014848)4.41778142
43negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.40213029
44regulation of skeletal muscle contraction (GO:0014819)4.39245030
45striated muscle hypertrophy (GO:0014897)4.31378532
46plasma membrane repair (GO:0001778)4.20576917
47motile cilium assembly (GO:0044458)4.17487167
48regulation of cardiac muscle contraction (GO:0055117)4.16445578
49regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.15091810
50regulation of cardioblast differentiation (GO:0051890)4.12771740
51regulation of membrane repolarization (GO:0060306)4.08656095
52response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.03218785
53sarcoplasmic reticulum calcium ion transport (GO:0070296)3.99554961
54cardiac chamber formation (GO:0003207)3.98436093
55regulation of cardiac muscle cell contraction (GO:0086004)3.93910524
56tricarboxylic acid cycle (GO:0006099)3.90290783
57negative regulation of striated muscle cell apoptotic process (GO:0010664)3.90009285
58relaxation of smooth muscle (GO:0044557)3.87031517
59relaxation of cardiac muscle (GO:0055119)3.81026944
60desmosome organization (GO:0002934)3.80878141
61muscle hypertrophy (GO:0014896)3.78086637
62regulation of heart rate (GO:0002027)3.77930292
63actin filament-based movement (GO:0030048)3.77705646
64cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73530693
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.73516759
66cell communication involved in cardiac conduction (GO:0086065)3.72957981
67detection of calcium ion (GO:0005513)3.63678636
68regulation of heart contraction (GO:0008016)3.62238854
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57673408
70mitochondrial respiratory chain complex I assembly (GO:0032981)3.57673408
71NADH dehydrogenase complex assembly (GO:0010257)3.57673408
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.52882675
73negative regulation of potassium ion transport (GO:0043267)3.52436025
74positive regulation of cardiac muscle cell differentiation (GO:2000727)3.50620673
75regulation of acyl-CoA biosynthetic process (GO:0050812)3.47938652
76muscle fiber development (GO:0048747)3.46416599
77cardiac muscle cell action potential involved in contraction (GO:0086002)3.45588382
78cardiac muscle cell action potential (GO:0086001)3.45513936
79response to epinephrine (GO:0071871)3.42327755
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.39669982
81peptidyl-histidine modification (GO:0018202)3.39352390
82protein complex biogenesis (GO:0070271)3.38635596
83cardiac conduction (GO:0061337)3.37346527
84regulation of muscle contraction (GO:0006937)3.35245400
85iron-sulfur cluster assembly (GO:0016226)3.34133589
86metallo-sulfur cluster assembly (GO:0031163)3.34133589
87ATP biosynthetic process (GO:0006754)3.33851894
88cardiac ventricle formation (GO:0003211)3.33778721
89regulation of ATP catabolic process (GO:1903289)3.29488103
90regulation of ATPase activity (GO:0043462)3.29488103
91positive regulation of potassium ion transmembrane transport (GO:1901381)3.26508577
92negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.24550341
93cellular response to epinephrine stimulus (GO:0071872)3.24468833
94regulation of cardiac muscle cell differentiation (GO:2000725)3.23597915
95regulation of heart rate by cardiac conduction (GO:0086091)3.22900179
96relaxation of muscle (GO:0090075)3.22187732
97atrial septum morphogenesis (GO:0060413)3.21465181
98preassembly of GPI anchor in ER membrane (GO:0016254)3.21443808
99rRNA modification (GO:0000154)3.19510962
100positive regulation of heart rate (GO:0010460)3.17938653
101ventricular cardiac muscle cell development (GO:0055015)3.17526859
102oxidative phosphorylation (GO:0006119)3.15636324
103multicellular organism reproduction (GO:0032504)3.15553721
104cGMP-mediated signaling (GO:0019934)3.15022433
105amino acid salvage (GO:0043102)3.14415345
106L-methionine salvage (GO:0071267)3.14415345
107L-methionine biosynthetic process (GO:0071265)3.14415345
108cell communication by electrical coupling (GO:0010644)3.13145476
109striated muscle cell development (GO:0055002)3.11328548
110positive regulation of catecholamine secretion (GO:0033605)3.11270345
111rRNA methylation (GO:0031167)3.11138606
112adrenergic receptor signaling pathway (GO:0071875)3.08814241
113positive regulation of cation channel activity (GO:2001259)3.07373990
114negative regulation of glucose import (GO:0046325)3.07308655
115regulation of coenzyme metabolic process (GO:0051196)3.05881909
116regulation of cofactor metabolic process (GO:0051193)3.05881909
117cardiac muscle adaptation (GO:0014887)3.02370048
118cardiac muscle hypertrophy in response to stress (GO:0014898)3.02370048
119muscle hypertrophy in response to stress (GO:0003299)3.02370048
120trabecula formation (GO:0060343)2.97705347
121purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.96943687
122negative regulation of cell size (GO:0045792)2.96606674
123regulation of muscle system process (GO:0090257)2.95578888
124regulation of striated muscle cell apoptotic process (GO:0010662)2.95371906
125response to caffeine (GO:0031000)2.94995873
126mitochondrial respiratory chain complex assembly (GO:0033108)2.93149701
127behavioral response to nicotine (GO:0035095)2.92942686
128regulation of action potential (GO:0098900)2.91411904
129positive regulation of vascular permeability (GO:0043117)2.91306452
130muscle contraction (GO:0006936)2.85609158
131detection of light stimulus involved in sensory perception (GO:0050962)2.80933507
132detection of light stimulus involved in visual perception (GO:0050908)2.80933507
133muscle system process (GO:0003012)2.78954282
134respiratory chain complex IV assembly (GO:0008535)2.78252768
135fatty acid transmembrane transport (GO:1902001)2.75085660
136muscle cell fate commitment (GO:0042693)2.70701462
137carnitine transmembrane transport (GO:1902603)2.68838498
138heme transport (GO:0015886)2.68692783
139negative regulation of multicellular organism growth (GO:0040015)2.67337585
140regulation of acrosome reaction (GO:0060046)2.65743106
141response to nitrosative stress (GO:0051409)2.64941651
142DNA deamination (GO:0045006)2.64429418
143muscle cell cellular homeostasis (GO:0046716)2.63090867
144methionine biosynthetic process (GO:0009086)2.62402125
145coenzyme catabolic process (GO:0009109)2.61652176
146growth hormone secretion (GO:0030252)2.61569731
147ADP metabolic process (GO:0046031)2.60170888
148DNA integration (GO:0015074)2.57005768
149smooth muscle contraction (GO:0006939)2.56510845
150muscle cell development (GO:0055001)2.54315922
151cardiolipin metabolic process (GO:0032048)2.53091877
152carnitine shuttle (GO:0006853)2.52530400
153cytochrome complex assembly (GO:0017004)2.51275845
154mannosylation (GO:0097502)2.49801901
155amino-acid betaine transport (GO:0015838)2.48961776
156carnitine transport (GO:0015879)2.48961776
157skeletal muscle contraction (GO:0003009)2.47697408
158cellular ketone body metabolic process (GO:0046950)2.46329640
159mitochondrial DNA replication (GO:0006264)2.46289361
160DNA methylation involved in gamete generation (GO:0043046)2.45019199
161cilium or flagellum-dependent cell motility (GO:0001539)2.44820326
162protein import into peroxisome matrix (GO:0016558)2.44715309
163positive regulation of protein kinase C signaling (GO:0090037)2.43816127

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.27844529
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.77747922
3EZH2_22144423_ChIP-Seq_EOC_Human4.87588676
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.80340409
5EP300_21415370_ChIP-Seq_HL-1_Mouse3.42941698
6IGF1R_20145208_ChIP-Seq_DFB_Human3.13310456
7GBX2_23144817_ChIP-Seq_PC3_Human2.95964680
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.74578596
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66698002
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.61573104
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.56051155
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.52204671
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.51308455
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49660800
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.40220873
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.33521807
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.31846620
18TAF15_26573619_Chip-Seq_HEK293_Human2.30688634
19CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.26340198
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24063859
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24063859
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.21460542
23ESR1_20079471_ChIP-ChIP_T-47D_Human2.19866287
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13143281
25* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.12741232
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06946267
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06610070
28VDR_22108803_ChIP-Seq_LS180_Human2.04742210
29ERA_21632823_ChIP-Seq_H3396_Human2.01174662
30BP1_19119308_ChIP-ChIP_Hs578T_Human2.00799957
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95479993
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.93483264
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.91769538
34ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88084892
35MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86264840
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.85844919
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84331691
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.76335059
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73994312
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.73563074
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.72520421
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.70842244
43TBX20_22328084_ChIP-Seq_HEART_Mouse1.70575190
44TBX20_22080862_ChIP-Seq_HEART_Mouse1.70575190
45* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68415876
46* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67873379
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66894965
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.63833554
49PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.63643421
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63399925
51AR_21572438_ChIP-Seq_LNCaP_Human1.62123250
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.61936468
53SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.61526194
54NANOG_20526341_ChIP-Seq_ESCs_Human1.61072476
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57659964
56POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57315554
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56988663
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.55782458
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55279179
60OCT4_20526341_ChIP-Seq_ESCs_Human1.53087807
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.51806477
62P68_20966046_ChIP-Seq_HELA_Human1.51522773
63* CTCF_27219007_Chip-Seq_Bcells_Human1.51167901
64ZNF274_21170338_ChIP-Seq_K562_Hela1.48540177
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.47670659
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47093150
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45959389
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.42622811
69P300_19829295_ChIP-Seq_ESCs_Human1.42414844
70SMAD4_21799915_ChIP-Seq_A2780_Human1.41985605
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39695114
72RAC3_21632823_ChIP-Seq_H3396_Human1.38968821
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37792376
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37068178
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.36637981
76E2F1_20622854_ChIP-Seq_HELA_Human1.32927704
77FUS_26573619_Chip-Seq_HEK293_Human1.30709996
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30005659
79CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27959701
80DROSHA_22980978_ChIP-Seq_HELA_Human1.27731476
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27489488
82* GATA3_21878914_ChIP-Seq_MCF-7_Human1.27063936
83BCAT_22108803_ChIP-Seq_LS180_Human1.25609666
84UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23422460
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23098486
86PHF8_20622854_ChIP-Seq_HELA_Human1.22609556
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22319716
88E2F1_17053090_ChIP-ChIP_MCF-7_Human1.22085413
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.21797992
90BCL6_27268052_Chip-Seq_Bcells_Human1.21325318
91ELF1_20517297_ChIP-Seq_JURKAT_Human1.21099973
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20443173
93RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.19310448
94TP53_18474530_ChIP-ChIP_U2OS_Human1.18562420
95EWS_26573619_Chip-Seq_HEK293_Human1.18280706
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16753236
97EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.16288276
98PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14498866
99TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.13531490
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12374431
101* CTCF_21964334_Chip-Seq_Bcells_Human1.12260738
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.12126109
103* WDR5_24793694_ChIP-Seq_LNCAP_Human1.10177342
104* NCOR_22424771_ChIP-Seq_293T_Human1.10156244
105BCOR_27268052_Chip-Seq_Bcells_Human1.10146772
106IRF1_19129219_ChIP-ChIP_H3396_Human1.10067931
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09856880
108AHR_22903824_ChIP-Seq_MCF-7_Human1.09631454
109ER_23166858_ChIP-Seq_MCF-7_Human1.09413045
110TP53_22573176_ChIP-Seq_HFKS_Human1.08183946
111SMC4_20622854_ChIP-Seq_HELA_Human1.07803272
112TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07762797
113TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07180402
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06318751
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05928925
116MYC_19829295_ChIP-Seq_ESCs_Human1.05122934
117CTCF_20526341_ChIP-Seq_ESCs_Human1.04911268
118CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04828949
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.04469395
120RING1B_27294783_Chip-Seq_ESCs_Mouse1.02929218
121P53_21459846_ChIP-Seq_SAOS-2_Human1.01870901
122PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01430402
123ISL1_27105846_Chip-Seq_CPCs_Mouse1.01290253
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.01034471
125EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00356543
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.99766856
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99682428
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98447958
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97816870
130MYC_18940864_ChIP-ChIP_HL60_Human0.97360232
131TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.97163365
132* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96977817
133P300_27268052_Chip-Seq_Bcells_Human0.96596528
134KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.96482901
135SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96189560
136EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96174236
137YY1_22570637_ChIP-Seq_MALME-3M_Human0.95666273
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95179441
139ETS1_20019798_ChIP-Seq_JURKAT_Human0.95006756
140* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94835553
141GATA4_21415370_ChIP-Seq_HL-1_Mouse0.94828598
142TAF2_19829295_ChIP-Seq_ESCs_Human0.94744094
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.94225543
144* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94178977
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.93562982
146PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93285917
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.92458660
148SOX2_21211035_ChIP-Seq_LN229_Gbm0.92356111
149VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91945138
150RNF2_27304074_Chip-Seq_NSC_Mouse0.91419713
151TP53_16413492_ChIP-PET_HCT116_Human0.91164373
152ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90679256
153HOXB7_26014856_ChIP-Seq_BT474_Human0.90668285
154* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90623515
155TCF4_23295773_ChIP-Seq_U87_Human0.90601507
156CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90593455
157TDRD3_21172665_ChIP-Seq_MCF-7_Human0.90579610
158NANOG_18555785_Chip-Seq_ESCs_Mouse0.90274961
159PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89856142
160RUNX2_22187159_ChIP-Seq_PCA_Human0.89382976
161ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.88648406
162TP63_22573176_ChIP-Seq_HFKS_Human0.88561409
163P53_22387025_ChIP-Seq_ESCs_Mouse0.88266934
164PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87833244
165FOXP1_21924763_ChIP-Seq_HESCs_Human0.87231410
166GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86762167
167AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86664396
168CIITA_25753668_ChIP-Seq_RAJI_Human0.86481457
169CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.85810512
170* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.84295471
171* CBP_20019798_ChIP-Seq_JUKART_Human0.84295471
172ERG_20517297_ChIP-Seq_VCAP_Human0.83425090
173RARB_24833708_ChIP-Seq_LIVER_Mouse0.83158211
174KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82436868
175TET1_21451524_ChIP-Seq_MESCs_Mouse0.81788319
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.81547723
177* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.80640484
178RXR_22108803_ChIP-Seq_LS180_Human0.79701533

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.38327128
2MP0004084_abnormal_cardiac_muscle5.35879051
3MP0004215_abnormal_myocardial_fiber4.56758357
4MP0000751_myopathy4.53139765
5MP0003646_muscle_fatigue4.13085233
6MP0004036_abnormal_muscle_relaxation3.99561308
7MP0005330_cardiomyopathy3.91215251
8MP0000749_muscle_degeneration3.40552294
9MP0002972_abnormal_cardiac_muscle3.35032517
10MP0003137_abnormal_impulse_conducting3.15788540
11MP0003828_pulmonary_edema2.76121933
12MP0005620_abnormal_muscle_contractility2.75120731
13MP0008775_abnormal_heart_ventricle2.69918861
14MP0004484_altered_response_of2.45881451
15MP0004085_abnormal_heartbeat2.45506174
16MP0004087_abnormal_muscle_fiber2.45068123
17MP0001986_abnormal_taste_sensitivity2.41202325
18MP0005385_cardiovascular_system_phenoty2.39824953
19MP0001544_abnormal_cardiovascular_syste2.39824953
20MP0006138_congestive_heart_failure2.36856424
21MP0005646_abnormal_pituitary_gland2.36728222
22MP0003718_maternal_effect2.29038414
23MP0010630_abnormal_cardiac_muscle2.26427436
24MP0005410_abnormal_fertilization2.15674525
25MP0000750_abnormal_muscle_regeneration2.15424003
26MP0004145_abnormal_muscle_electrophysio2.15340706
27MP0002160_abnormal_reproductive_system2.14086794
28MP0009379_abnormal_foot_pigmentation2.13414615
29MP0002106_abnormal_muscle_physiology2.10670111
30MP0003950_abnormal_plasma_membrane2.07786931
31MP0000013_abnormal_adipose_tissue2.04684350
32MP0002127_abnormal_cardiovascular_syste1.94449133
33MP0001661_extended_life_span1.76532910
34MP0005369_muscle_phenotype1.73560315
35MP0003880_abnormal_central_pattern1.62519720
36MP0005174_abnormal_tail_pigmentation1.61176685
37MP0004510_myositis1.60042337
38MP0002102_abnormal_ear_morphology1.57061014
39MP0000538_abnormal_urinary_bladder1.50570952
40MP0001756_abnormal_urination1.48749858
41MP0000759_abnormal_skeletal_muscle1.48405864
42MP0003221_abnormal_cardiomyocyte_apopto1.44620171
43MP0005645_abnormal_hypothalamus_physiol1.42092048
44MP0004147_increased_porphyrin_level1.40581326
45MP0005670_abnormal_white_adipose1.38610079
46MP0002332_abnormal_exercise_endurance1.37898057
47MP0005253_abnormal_eye_physiology1.37812285
48MP0005551_abnormal_eye_electrophysiolog1.35594824
49MP0000747_muscle_weakness1.34268443
50MP0001664_abnormal_digestion1.32814172
51MP0003315_abnormal_perineum_morphology1.31840850
52MP0004130_abnormal_muscle_cell1.31299143
53MP0002234_abnormal_pharynx_morphology1.30956680
54MP0000372_irregular_coat_pigmentation1.28745014
55MP0005395_other_phenotype1.27955846
56MP0005171_absent_coat_pigmentation1.27854895
57MP0002269_muscular_atrophy1.26161081
58MP0003567_abnormal_fetal_cardiomyocyte1.23574497
59MP0006036_abnormal_mitochondrial_physio1.23193431
60MP0005409_darkened_coat_color1.20313445
61MP0005451_abnormal_body_composition1.19226109
62MP0005083_abnormal_biliary_tract1.17080789
63MP0001348_abnormal_lacrimal_gland1.15601584
64MP0008789_abnormal_olfactory_epithelium1.15266104
65MP0004233_abnormal_muscle_weight1.14997489
66MP0010368_abnormal_lymphatic_system1.11512930
67MP0006276_abnormal_autonomic_nervous1.10085144
68MP0002822_catalepsy1.10022430
69MP0002653_abnormal_ependyma_morphology1.07062169
70MP0003011_delayed_dark_adaptation1.06649577
71MP0000230_abnormal_systemic_arterial1.06383564
72MP0005389_reproductive_system_phenotype1.02758410
73MP0003045_fibrosis1.02668806
74MP0000003_abnormal_adipose_tissue0.92534656
75MP0005165_increased_susceptibility_to0.92082460
76MP0005220_abnormal_exocrine_pancreas0.91597539
77MP0000266_abnormal_heart_morphology0.90614465
78MP0005360_urolithiasis0.90329032
79MP0006292_abnormal_olfactory_placode0.86789070
80MP0001879_abnormal_lymphatic_vessel0.86467701
81MP0003252_abnormal_bile_duct0.85960679
82MP0003941_abnormal_skin_development0.85495017
83MP0001529_abnormal_vocalization0.85195468
84MP0000631_abnormal_neuroendocrine_gland0.84969759
85MP0001188_hyperpigmentation0.82617745
86MP0006072_abnormal_retinal_apoptosis0.81898558
87MP0000015_abnormal_ear_pigmentation0.80376541
88MP0005499_abnormal_olfactory_system0.79838992
89MP0005394_taste/olfaction_phenotype0.79838992
90MP0005423_abnormal_somatic_nervous0.78598750
91MP0003136_yellow_coat_color0.78425784
92MP0009840_abnormal_foam_cell0.77639320
93MP0001502_abnormal_circadian_rhythm0.77479521
94MP0008877_abnormal_DNA_methylation0.76472428
95MP0009384_cardiac_valve_regurgitation0.75633068
96MP0001764_abnormal_homeostasis0.74924147
97MP0004272_abnormal_basement_membrane0.73801769
98MP0000462_abnormal_digestive_system0.73470415
99MP0001919_abnormal_reproductive_system0.73067617
100MP0001929_abnormal_gametogenesis0.70967278
101MP0002249_abnormal_larynx_morphology0.70791786
102MP0000343_altered_response_to0.70391709
103MP0009745_abnormal_behavioral_response0.69742791
104MP0002138_abnormal_hepatobiliary_system0.69683313
105MP0000427_abnormal_hair_cycle0.69502693
106MP0009046_muscle_twitch0.69245813
107MP0006035_abnormal_mitochondrial_morpho0.68276322
108MP0003385_abnormal_body_wall0.68182632
109MP0003698_abnormal_male_reproductive0.67410462
110MP0004381_abnormal_hair_follicle0.67160261
111MP0002132_abnormal_respiratory_system0.67131418
112MP0002638_abnormal_pupillary_reflex0.67004670
113MP0000733_abnormal_muscle_development0.66789971
114MP0000383_abnormal_hair_follicle0.66438244
115MP0003122_maternal_imprinting0.66217807
116MP0005595_abnormal_vascular_smooth0.66102820
117MP0005623_abnormal_meninges_morphology0.66091379
118MP0001905_abnormal_dopamine_level0.65843880
119MP0008004_abnormal_stomach_pH0.65443922
120MP0002067_abnormal_sensory_capabilities0.64694536
121MP0000762_abnormal_tongue_morphology0.64605584
122MP0001486_abnormal_startle_reflex0.64385520
123MP0002272_abnormal_nervous_system0.64239537
124MP0001727_abnormal_embryo_implantation0.62232452
125MP0004924_abnormal_behavior0.62163525
126MP0005386_behavior/neurological_phenoty0.62163525
127MP0003279_aneurysm0.61876172
128MP0002735_abnormal_chemical_nociception0.60521500
129MP0002736_abnormal_nociception_after0.59634043
130MP0002128_abnormal_blood_circulation0.58356604
131MP0001968_abnormal_touch/_nociception0.58094986
132MP0001485_abnormal_pinna_reflex0.57729988
133MP0001440_abnormal_grooming_behavior0.55141910
134MP0002108_abnormal_muscle_morphology0.54522113
135MP0002064_seizures0.53965886
136MP0004142_abnormal_muscle_tone0.53545389
137MP0005388_respiratory_system_phenotype0.52411528
138MP0002133_abnormal_respiratory_system0.52411528
139MP0000767_abnormal_smooth_muscle0.51972984
140MP0010386_abnormal_urinary_bladder0.51813198
141MP0001501_abnormal_sleep_pattern0.51287242
142MP0003635_abnormal_synaptic_transmissio0.48628866
143MP0003948_abnormal_gas_homeostasis0.48185327
144MP0005377_hearing/vestibular/ear_phenot0.47243307
145MP0003878_abnormal_ear_physiology0.47243307
146MP0000516_abnormal_urinary_system0.46953578
147MP0005367_renal/urinary_system_phenotyp0.46953578
148MP0000026_abnormal_inner_ear0.45391234
149MP0005666_abnormal_adipose_tissue0.45148859
150MP0009250_abnormal_appendicular_skeleto0.42389555
151MP0001984_abnormal_olfaction0.40292312

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.26376859
2Ventricular tachycardia (HP:0004756)6.29247036
3Calf muscle hypertrophy (HP:0008981)6.03527792
4Atrial fibrillation (HP:0005110)5.96327870
5Muscle hypertrophy of the lower extremities (HP:0008968)5.72440952
6Primary atrial arrhythmia (HP:0001692)5.59363576
7Supraventricular tachycardia (HP:0004755)5.42103529
8Supraventricular arrhythmia (HP:0005115)5.30164524
9Abnormality of the calf musculature (HP:0001430)5.21230017
10Lipoatrophy (HP:0100578)5.09068334
11Subaortic stenosis (HP:0001682)5.06360304
12Abnormality of the left ventricular outflow tract (HP:0011103)5.06360304
13Syncope (HP:0001279)5.06309472
14Acute necrotizing encephalopathy (HP:0006965)4.86435678
15Prolonged QT interval (HP:0001657)4.83823536
16Muscle fiber splitting (HP:0003555)4.54589969
17Popliteal pterygium (HP:0009756)4.48564602
18Abnormal mitochondria in muscle tissue (HP:0008316)4.46303148
19Exercise-induced myalgia (HP:0003738)4.44837372
20Exercise-induced muscle cramps (HP:0003710)4.39512865
21Right ventricular cardiomyopathy (HP:0011663)4.33017121
22Mitochondrial inheritance (HP:0001427)4.31405618
23Progressive macrocephaly (HP:0004481)4.10451591
24Dilated cardiomyopathy (HP:0001644)4.07908359
25Palpitations (HP:0001962)4.06993960
26Ventricular arrhythmia (HP:0004308)3.90303529
27Hyporeflexia of lower limbs (HP:0002600)3.87568044
28Acute encephalopathy (HP:0006846)3.86345916
29Hepatocellular necrosis (HP:0001404)3.83062704
30Aplasia of the musculature (HP:0100854)3.77776081
31Hepatic necrosis (HP:0002605)3.70030806
32Increased CSF lactate (HP:0002490)3.68738292
33EMG: myopathic abnormalities (HP:0003458)3.67177475
34Ventricular fibrillation (HP:0001663)3.66435715
35Abnormal EKG (HP:0003115)3.47917305
36Double outlet right ventricle (HP:0001719)3.42351063
37Congenital malformation of the right heart (HP:0011723)3.42351063
38Aortic aneurysm (HP:0004942)3.41767411
39Distal arthrogryposis (HP:0005684)3.28597286
40Increased hepatocellular lipid droplets (HP:0006565)3.19829242
41Bundle branch block (HP:0011710)3.18149018
42Exercise intolerance (HP:0003546)3.11066223
43Asymmetric septal hypertrophy (HP:0001670)3.08247417
44Increased intramyocellular lipid droplets (HP:0012240)3.07757620
45Myotonia (HP:0002486)3.07663331
46Left ventricular hypertrophy (HP:0001712)3.04929366
47Congenital stationary night blindness (HP:0007642)3.02455940
48Reduced antithrombin III activity (HP:0001976)2.99525233
49Lipid accumulation in hepatocytes (HP:0006561)2.98852565
50Hypoplasia of the pons (HP:0012110)2.92784445
51Respiratory failure (HP:0002878)2.86929834
52Cerebral edema (HP:0002181)2.85431904
53Myoglobinuria (HP:0002913)2.84016458
54Increased muscle lipid content (HP:0009058)2.82566760
55Abnormal ciliary motility (HP:0012262)2.81214951
56Optic disc pallor (HP:0000543)2.80072351
57Heart block (HP:0012722)2.79011806
58Type 2 muscle fiber atrophy (HP:0003554)2.74367622
59Attenuation of retinal blood vessels (HP:0007843)2.71897890
60Abnormal atrioventricular conduction (HP:0005150)2.70209267
61Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.68761799
62Testicular atrophy (HP:0000029)2.62109688
63Fetal akinesia sequence (HP:0001989)2.62046189
64Palmoplantar keratoderma (HP:0000982)2.61630996
65Lactic acidosis (HP:0003128)2.55234943
66Ulnar deviation of the wrist (HP:0003049)2.53831063
67Aplasia/Hypoplasia involving the musculature (HP:0001460)2.52053101
68Atrioventricular block (HP:0001678)2.50872345
69Muscle fiber atrophy (HP:0100295)2.49053689
70Pulmonary artery stenosis (HP:0004415)2.48742228
71Abnormality of the pons (HP:0007361)2.46096004
72Type I transferrin isoform profile (HP:0003642)2.44730237
73Rib fusion (HP:0000902)2.42687748
74Renal Fanconi syndrome (HP:0001994)2.42388107
75Absent thumb (HP:0009777)2.40291390
76Cerebellar dysplasia (HP:0007033)2.39098942
77Hypoplastic left heart (HP:0004383)2.33775080
78Ragged-red muscle fibers (HP:0003200)2.31927694
79Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.29366846
80Distal lower limb muscle weakness (HP:0009053)2.27918186
81Round ear (HP:0100830)2.27857259
82Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.26890541
83Neck muscle weakness (HP:0000467)2.25209889
84Pancreatic cysts (HP:0001737)2.24803535
85Abnormal protein N-linked glycosylation (HP:0012347)2.24367242
86Abnormal protein glycosylation (HP:0012346)2.24367242
87Abnormal glycosylation (HP:0012345)2.24367242
88Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24367242
89Muscle fiber inclusion bodies (HP:0100299)2.21433017
90Periauricular skin pits (HP:0100277)2.18987407
91Preauricular pit (HP:0004467)2.18987407
92Clumsiness (HP:0002312)2.18943530
93Increased connective tissue (HP:0009025)2.18297190
94Decreased electroretinogram (ERG) amplitude (HP:0000654)2.18027185
95Weak cry (HP:0001612)2.17491944
96Abnormal respiratory motile cilium physiology (HP:0012261)2.15897470
97Conjunctival hamartoma (HP:0100780)2.13350440
98Type II lissencephaly (HP:0007260)2.13114851
99Malignant hyperthermia (HP:0002047)2.12462306
100Abnormality of alanine metabolism (HP:0010916)2.10291683
101Hyperalaninemia (HP:0003348)2.10291683
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.10291683
103Respiratory difficulties (HP:0002880)2.09703560
104Rhabdomyolysis (HP:0003201)2.09319298
105Abnormality of the tricuspid valve (HP:0001702)2.05582152
106Dyschromatopsia (HP:0007641)2.03773583
107Pheochromocytoma (HP:0002666)2.02776996
108Muscle stiffness (HP:0003552)2.02290955
109Amniotic constriction ring (HP:0009775)2.01295564
110Abnormality of placental membranes (HP:0011409)2.01295564
111Fatigable weakness (HP:0003473)2.00566559
112Abnormality of the neuromuscular junction (HP:0003398)2.00566559
113Nemaline bodies (HP:0003798)2.00125404
114Absent phalangeal crease (HP:0006109)1.98839553
115Increased serum lactate (HP:0002151)1.98791745
116Ketosis (HP:0001946)1.97867349
117Myopathic facies (HP:0002058)1.97030887
118Gowers sign (HP:0003391)1.93174072
119Severe muscular hypotonia (HP:0006829)1.92482418
120Increased serum pyruvate (HP:0003542)1.91327459
121Abnormality of glycolysis (HP:0004366)1.91327459
122Facial hemangioma (HP:0000329)1.91152002
123Leukodystrophy (HP:0002415)1.90385193
124Infantile muscular hypotonia (HP:0008947)1.89703043
125Hypoplastic heart (HP:0001961)1.88975097
126Congenital sensorineural hearing impairment (HP:0008527)1.88751213
127Abnormality of the foot musculature (HP:0001436)1.87816970
128Bradycardia (HP:0001662)1.86329443
129Areflexia of lower limbs (HP:0002522)1.85992862
130Decreased activity of mitochondrial respiratory chain (HP:0008972)1.85394206
131Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.85394206
132Sudden cardiac death (HP:0001645)1.84920142
133Hypophosphatemic rickets (HP:0004912)1.84505415
134Patent foramen ovale (HP:0001655)1.80373247
135Difficulty running (HP:0009046)1.80364751
136X-linked dominant inheritance (HP:0001423)1.79206915
137Dysmetric saccades (HP:0000641)1.79043557
138Neuroendocrine neoplasm (HP:0100634)1.77659175
139Exertional dyspnea (HP:0002875)1.77612479
140Pendular nystagmus (HP:0012043)1.77294174
141Medial flaring of the eyebrow (HP:0010747)1.77166602
142Progressive cerebellar ataxia (HP:0002073)1.77074081
143Poikiloderma (HP:0001029)1.75802030
144Congestive heart failure (HP:0001635)1.73786254
145Chorioretinal atrophy (HP:0000533)1.73597041
146Birth length less than 3rd percentile (HP:0003561)1.71837057
147Pancreatic fibrosis (HP:0100732)1.70648861
148Molar tooth sign on MRI (HP:0002419)1.70526707
149Abnormality of midbrain morphology (HP:0002418)1.70526707
150Facial diplegia (HP:0001349)1.70450787
151Lip pit (HP:0100267)1.70216639
152Parakeratosis (HP:0001036)1.69733930
153Generalized muscle weakness (HP:0003324)1.69667548
154Type 1 muscle fiber predominance (HP:0003803)1.67402328
155Dicarboxylic aciduria (HP:0003215)1.66728605
156Abnormality of dicarboxylic acid metabolism (HP:0010995)1.66728605
157Ketoacidosis (HP:0001993)1.63595906
158Difficulty climbing stairs (HP:0003551)1.62848067
159Steppage gait (HP:0003376)1.62441411
160Neoplasm of head and neck (HP:0012288)1.62232508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.68952386
2OBSCN3.89193838
3TTN3.69554519
4FRK3.60323945
5DMPK3.04107928
6LMTK23.03610505
7STK242.96465954
8PHKG12.92374927
9PHKG22.92374927
10CASK2.73951574
11GRK72.72338251
12PIK3CA2.64190221
13STK392.32209774
14MUSK2.31946630
15TAOK32.26836414
16AKT32.19270276
17TIE12.10434200
18WNK41.93241453
19PKN11.88022508
20PIK3CG1.85582796
21PDK31.67547383
22PDK41.67547383
23MAP4K21.67272834
24CAMK2D1.65084165
25CDC42BPA1.57126093
26PIM21.50761007
27PAK31.47534548
28NUAK11.40890559
29KDR1.38038541
30ZAK1.36937896
31TNIK1.35370405
32CAMK2A1.32433982
33EPHB21.29039320
34ILK1.28430348
35DAPK31.28336868
36INSRR1.27335592
37MAPK151.27305677
38LATS11.24088519
39MAPK121.20791849
40TNK21.16125682
41ROCK11.15593281
42TESK21.15505408
43PRKD11.15421639
44MARK31.12937294
45EEF2K1.12674923
46PTK2B1.12116619
47PRKD31.10152078
48PAK21.09159520
49MST41.06836831
50ACVR1B1.06425490
51CSNK1A1L1.06385567
52TLK11.06385524
53WNK11.06201862
54PDK21.06178852
55ROCK21.04878913
56TRPM71.03878950
57PRKCE1.01817393
58STK160.98234718
59NME10.97322700
60MAP2K70.94300851
61CAMK10.93793836
62MKNK20.93055765
63TRIM280.89288657
64NME20.86736793
65STK40.86174546
66PRKAA20.85092816
67STK38L0.80382492
68GRK50.79722321
69CAMK2B0.79384197
70CCNB10.79271864
71MAP4K10.78494319
72VRK10.75200700
73NEK20.74666992
74MAPK130.74008832
75PRPF4B0.72102344
76TRIB30.72091773
77MAP3K120.71627804
78SCYL20.71458418
79CAMK2G0.71175911
80MTOR0.69773273
81UHMK10.68670324
82PRKCQ0.67982153
83MAP2K20.67074727
84MELK0.66558391
85CSNK1G30.65892640
86TGFBR20.65835367
87MAP3K50.65491285
88MAP3K110.63675043
89PRKACA0.63020437
90RPS6KB20.62403461
91PINK10.60455938
92CHUK0.57403357
93PRKG10.57030502
94MAPKAPK30.56432818
95CAMK40.56107525
96PLK20.55154611
97MAP3K40.54992687
98CSNK1G10.53445589
99BCKDK0.52455426
100ADRBK20.50839931
101ADRBK10.50521659
102MAPK110.49941958
103PRKD20.48476412
104MAP3K130.48469468
105BMPR20.47477516
106BMPR1B0.47045232
107AURKA0.46318428
108PRKACB0.45254838
109OXSR10.44988013
110MAP3K70.43398319
111SGK4940.43109571
112SGK2230.43109571
113ARAF0.42945299
114PKN20.42599159
115PAK10.42140560
116VRK20.42120591
117EPHA40.41760370
118MAP2K10.40170997
119NLK0.40115671
120EIF2AK30.39426736
121RPS6KA60.39340579
122NEK60.39053943
123MAP3K10.38925052
124NEK90.38510508
125IRAK10.37836080
126CSNK1D0.35921040
127CLK10.35915293
128ICK0.35560295
129CSNK1A10.35463189
130PNCK0.35143011
131DYRK30.34696144
132RAF10.34584191
133MAPK70.34540215
134FES0.33309284
135STK110.32985691
136RPS6KC10.31158864
137RPS6KL10.31158864
138LIMK10.30812414
139FGR0.30568969
140MAP3K30.29477445
141IRAK20.27333298
142MAP2K40.27084769
143PRKAA10.26524385
144RIPK40.24576925
145PRKACG0.24527222
146FER0.23504833
147PRKG20.23162124
148DYRK1A0.22792826
149GRK10.22492162
150SGK10.22182399
151RPS6KA50.21503857

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.47448861
2Cardiac muscle contraction_Homo sapiens_hsa042605.30006809
3Parkinsons disease_Homo sapiens_hsa050124.93490913
4Alzheimers disease_Homo sapiens_hsa050103.94742788
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55264446
6Dilated cardiomyopathy_Homo sapiens_hsa054143.51571351
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.43274341
8Huntingtons disease_Homo sapiens_hsa050163.36410150
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049323.16937181
10Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.58594515
11Nitrogen metabolism_Homo sapiens_hsa009102.44853871
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.19911045
13Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94748259
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89500808
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.89304752
16Propanoate metabolism_Homo sapiens_hsa006401.79804279
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.75553941
18Fanconi anemia pathway_Homo sapiens_hsa034601.73444636
19Sulfur relay system_Homo sapiens_hsa041221.63779300
20RNA polymerase_Homo sapiens_hsa030201.59958714
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55383331
22Peroxisome_Homo sapiens_hsa041461.54347515
23Fatty acid elongation_Homo sapiens_hsa000621.52346318
24Homologous recombination_Homo sapiens_hsa034401.40207222
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.36338299
26Calcium signaling pathway_Homo sapiens_hsa040201.36269813
27Selenocompound metabolism_Homo sapiens_hsa004501.34249384
28Linoleic acid metabolism_Homo sapiens_hsa005911.31341702
29cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28755166
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23318289
31ABC transporters_Homo sapiens_hsa020101.21018050
32Viral myocarditis_Homo sapiens_hsa054161.19873280
33Chemical carcinogenesis_Homo sapiens_hsa052041.19573472
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.19201573
35Nicotine addiction_Homo sapiens_hsa050331.18282034
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.17624990
37Systemic lupus erythematosus_Homo sapiens_hsa053221.16867534
38Taste transduction_Homo sapiens_hsa047421.16423193
39Vascular smooth muscle contraction_Homo sapiens_hsa042701.14733908
40Base excision repair_Homo sapiens_hsa034101.14135181
41Renin secretion_Homo sapiens_hsa049241.09282930
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.07315442
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.05520226
44Purine metabolism_Homo sapiens_hsa002301.03995162
45Ribosome_Homo sapiens_hsa030101.00951827
46Circadian entrainment_Homo sapiens_hsa047131.00274472
47Serotonergic synapse_Homo sapiens_hsa047260.99287293
48Oxytocin signaling pathway_Homo sapiens_hsa049210.98510007
49Fructose and mannose metabolism_Homo sapiens_hsa000510.98458095
50Fatty acid degradation_Homo sapiens_hsa000710.97310074
51Carbon metabolism_Homo sapiens_hsa012000.96888368
52Circadian rhythm_Homo sapiens_hsa047100.95876984
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94737932
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92266493
55Alcoholism_Homo sapiens_hsa050340.90419246
56Sulfur metabolism_Homo sapiens_hsa009200.87966125
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87454619
58Hedgehog signaling pathway_Homo sapiens_hsa043400.87293923
59Gastric acid secretion_Homo sapiens_hsa049710.85851136
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.84642806
61Olfactory transduction_Homo sapiens_hsa047400.83092840
62Morphine addiction_Homo sapiens_hsa050320.83090033
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.81805240
64Basal transcription factors_Homo sapiens_hsa030220.79257386
65cAMP signaling pathway_Homo sapiens_hsa040240.79225585
66Arginine and proline metabolism_Homo sapiens_hsa003300.77512153
67Pyruvate metabolism_Homo sapiens_hsa006200.77374935
68Glutathione metabolism_Homo sapiens_hsa004800.76492389
69Salivary secretion_Homo sapiens_hsa049700.76173401
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75651833
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.75309874
72Glutamatergic synapse_Homo sapiens_hsa047240.75048228
73Tryptophan metabolism_Homo sapiens_hsa003800.74816845
74PPAR signaling pathway_Homo sapiens_hsa033200.74428448
75beta-Alanine metabolism_Homo sapiens_hsa004100.73263406
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72626110
77RNA degradation_Homo sapiens_hsa030180.72120724
78Long-term potentiation_Homo sapiens_hsa047200.72117071
79Pyrimidine metabolism_Homo sapiens_hsa002400.72111037
80Axon guidance_Homo sapiens_hsa043600.71125107
81Insulin secretion_Homo sapiens_hsa049110.69254578
82Fatty acid metabolism_Homo sapiens_hsa012120.68102363
83Amphetamine addiction_Homo sapiens_hsa050310.67846330
84One carbon pool by folate_Homo sapiens_hsa006700.66675306
85Primary immunodeficiency_Homo sapiens_hsa053400.65820760
86ECM-receptor interaction_Homo sapiens_hsa045120.63141182
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.62491876
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62382746
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61678837
90GABAergic synapse_Homo sapiens_hsa047270.61406023
91GnRH signaling pathway_Homo sapiens_hsa049120.61314685
92Tight junction_Homo sapiens_hsa045300.60783042
93Dorso-ventral axis formation_Homo sapiens_hsa043200.60627988
94Nucleotide excision repair_Homo sapiens_hsa034200.59802168
95Long-term depression_Homo sapiens_hsa047300.59143690
96Cholinergic synapse_Homo sapiens_hsa047250.56160212
97Collecting duct acid secretion_Homo sapiens_hsa049660.55223648
98Lysine degradation_Homo sapiens_hsa003100.55023079
99Focal adhesion_Homo sapiens_hsa045100.54479585
100Melanogenesis_Homo sapiens_hsa049160.54197726
101Arginine biosynthesis_Homo sapiens_hsa002200.54153326
102Glucagon signaling pathway_Homo sapiens_hsa049220.54135446
103Gap junction_Homo sapiens_hsa045400.54103427
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52585322
105Retinol metabolism_Homo sapiens_hsa008300.51861324
106Vitamin digestion and absorption_Homo sapiens_hsa049770.50714793
107Dopaminergic synapse_Homo sapiens_hsa047280.50204019
108Butanoate metabolism_Homo sapiens_hsa006500.48875663
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48114417
110Protein export_Homo sapiens_hsa030600.47179424
111Sphingolipid metabolism_Homo sapiens_hsa006000.45528084
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.44293693
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42918449
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41898638
115AMPK signaling pathway_Homo sapiens_hsa041520.40123920
116Ether lipid metabolism_Homo sapiens_hsa005650.39466896
117mTOR signaling pathway_Homo sapiens_hsa041500.39451030
118Phototransduction_Homo sapiens_hsa047440.37979142
119Cocaine addiction_Homo sapiens_hsa050300.36610748
120Pancreatic secretion_Homo sapiens_hsa049720.35801234
121Metabolic pathways_Homo sapiens_hsa011000.31429868
122Phenylalanine metabolism_Homo sapiens_hsa003600.30424952
123Ovarian steroidogenesis_Homo sapiens_hsa049130.30207422
124HIF-1 signaling pathway_Homo sapiens_hsa040660.29947383
125Vibrio cholerae infection_Homo sapiens_hsa051100.28928373
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27948221
127Arachidonic acid metabolism_Homo sapiens_hsa005900.26650488
128Rheumatoid arthritis_Homo sapiens_hsa053230.24980107
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24524982
130Ras signaling pathway_Homo sapiens_hsa040140.23296473
131Insulin signaling pathway_Homo sapiens_hsa049100.23265084
132Estrogen signaling pathway_Homo sapiens_hsa049150.23124284
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22037792
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.21555347
135Amoebiasis_Homo sapiens_hsa051460.21351434
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21032002
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.19711973
138Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19376126
139Tyrosine metabolism_Homo sapiens_hsa003500.18998695
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18641653
141MAPK signaling pathway_Homo sapiens_hsa040100.18509134
142Renal cell carcinoma_Homo sapiens_hsa052110.18326410
143Platelet activation_Homo sapiens_hsa046110.17993369
144Wnt signaling pathway_Homo sapiens_hsa043100.17204798
145African trypanosomiasis_Homo sapiens_hsa051430.16433723
146Starch and sucrose metabolism_Homo sapiens_hsa005000.16432443
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.16178779
148Type II diabetes mellitus_Homo sapiens_hsa049300.16073466
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.15454089
150Adherens junction_Homo sapiens_hsa045200.15301239
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15126694
152Insulin resistance_Homo sapiens_hsa049310.13074634

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