FBXL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats and is localized in the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.57430556
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.00487270
3negative regulation of erythrocyte differentiation (GO:0045647)3.72894615
4regulation of B cell receptor signaling pathway (GO:0050855)3.62101807
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.49657599
6regulation of gamma-delta T cell activation (GO:0046643)3.45269239
7regulation of gamma-delta T cell differentiation (GO:0045586)3.33673311
8detection of molecule of bacterial origin (GO:0032490)3.30125693
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.26739757
10regulation of interferon-beta biosynthetic process (GO:0045357)3.22923666
11neutrophil activation involved in immune response (GO:0002283)3.21793469
12antigen processing and presentation of endogenous antigen (GO:0019883)3.17127437
13germinal center formation (GO:0002467)3.09174096
14detection of other organism (GO:0098543)3.06445076
15cellular extravasation (GO:0045123)2.98982462
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.98483170
17definitive hemopoiesis (GO:0060216)2.97933195
18axon ensheathment in central nervous system (GO:0032291)2.97056514
19central nervous system myelination (GO:0022010)2.97056514
20B cell receptor signaling pathway (GO:0050853)2.93212322
21negative regulation of interleukin-17 production (GO:0032700)2.92647361
22negative regulation of type 2 immune response (GO:0002829)2.92177395
23response to peptidoglycan (GO:0032494)2.90195392
24detection of external biotic stimulus (GO:0098581)2.83897157
25response to muramyl dipeptide (GO:0032495)2.82753164
26protein localization to endosome (GO:0036010)2.81653533
27relaxation of cardiac muscle (GO:0055119)2.80484037
28negative regulation of interleukin-12 production (GO:0032695)2.79782824
29negative regulation of lymphocyte mediated immunity (GO:0002707)2.76832360
30embryonic process involved in female pregnancy (GO:0060136)2.76534310
31macrophage activation (GO:0042116)2.74822030
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.73749316
33negative regulation of T-helper cell differentiation (GO:0045623)2.73749316
34negative thymic T cell selection (GO:0045060)2.68279723
35detection of bacterium (GO:0016045)2.65512244
36protein targeting to Golgi (GO:0000042)2.64539585
37cellular potassium ion homeostasis (GO:0030007)2.64328043
38negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.59115453
39L-amino acid import (GO:0043092)2.58810515
40negative T cell selection (GO:0043383)2.57918184
41response to host immune response (GO:0052572)2.57349799
42response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.57349799
43regulation of platelet aggregation (GO:0090330)2.56876347
44phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.54388480
45interleukin-6-mediated signaling pathway (GO:0070102)2.54297077
46hypotonic response (GO:0006971)2.53535797
47nerve growth factor signaling pathway (GO:0038180)2.50794694
48response to host (GO:0075136)2.48952468
49response to host defenses (GO:0052200)2.48952468
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.48952468
51lipopolysaccharide-mediated signaling pathway (GO:0031663)2.48733415
52response to laminar fluid shear stress (GO:0034616)2.48476977
53positive regulation of B cell differentiation (GO:0045579)2.47604167
54regulation of necroptotic process (GO:0060544)2.47397899
55regulation of regulatory T cell differentiation (GO:0045589)2.47218956
56response to interleukin-15 (GO:0070672)2.47179311
57positive regulation of Rap GTPase activity (GO:0032854)2.46737989
58import into cell (GO:0098657)2.46345124
59cellular response to thyroid hormone stimulus (GO:0097067)2.43482510
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.43081044
61positive regulation of receptor recycling (GO:0001921)2.41151871
62production of molecular mediator involved in inflammatory response (GO:0002532)2.40130428
63establishment of protein localization to Golgi (GO:0072600)2.39634577
64positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.39414417
65detection of biotic stimulus (GO:0009595)2.38770089
66histone H3-K36 demethylation (GO:0070544)2.38557527
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.38054241
68JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.37870985
69potassium ion import (GO:0010107)2.37097483
70tolerance induction (GO:0002507)2.37059454
71interkinetic nuclear migration (GO:0022027)2.36917779
72defense response to protozoan (GO:0042832)2.36550647
73positive T cell selection (GO:0043368)2.34982453
74negative regulation of leukocyte mediated immunity (GO:0002704)2.33012750
75early endosome to late endosome transport (GO:0045022)2.32290583
76positive regulation of interferon-alpha production (GO:0032727)2.32182202
77B cell homeostasis (GO:0001782)2.32005468
78retrograde transport, vesicle recycling within Golgi (GO:0000301)2.31830682
79positive thymic T cell selection (GO:0045059)2.31657975
80response to lipoprotein particle (GO:0055094)2.31471550
81locomotory exploration behavior (GO:0035641)2.30303253
82regulation of interleukin-17 production (GO:0032660)2.29307611
83negative regulation of neurotransmitter secretion (GO:0046929)2.29219655
84adhesion of symbiont to host cell (GO:0044650)2.29038685
85virion attachment to host cell (GO:0019062)2.29038685
86negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.28662465
87myeloid cell activation involved in immune response (GO:0002275)2.28570006
88positive regulation of macrophage cytokine production (GO:0060907)2.26997609
89T cell selection (GO:0045058)2.26307499
90regulation of macrophage cytokine production (GO:0010935)2.25638738
91leukocyte aggregation (GO:0070486)2.25328603
92T-helper cell differentiation (GO:0042093)2.24813434
93CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.24813434
94regulation of beta-amyloid formation (GO:1902003)2.24609558
95positive regulation of cardiac muscle hypertrophy (GO:0010613)2.24353303
96positive regulation of muscle hypertrophy (GO:0014742)2.24353303
97regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.23559891
98protein targeting to lysosome (GO:0006622)2.22342876
99establishment of protein localization to vacuole (GO:0072666)2.22342876
100protein targeting to vacuole (GO:0006623)2.22342876
101iron ion import (GO:0097286)2.21514744
102regulation of interferon-alpha production (GO:0032647)2.21420231
103regulation of alpha-beta T cell proliferation (GO:0046640)2.20674241
104positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.19914281
105neutrophil activation (GO:0042119)2.19657986
106photoreceptor cell differentiation (GO:0046530)2.18198485
107eye photoreceptor cell differentiation (GO:0001754)2.18198485
108amino acid import (GO:0043090)2.17560631
109axon ensheathment (GO:0008366)2.17173919
110ensheathment of neurons (GO:0007272)2.17173919
111negative regulation of neurotransmitter transport (GO:0051589)2.16654501
112myelination (GO:0042552)2.12294454
113sodium ion export (GO:0071436)2.11958346
114neuron remodeling (GO:0016322)2.10368674
115cytoskeletal anchoring at plasma membrane (GO:0007016)2.09897026
116positive regulation of cellular amide metabolic process (GO:0034250)2.08153367
117detection of calcium ion (GO:0005513)2.07522066
118creatine metabolic process (GO:0006600)2.05142066
119regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.00138965
120growth hormone receptor signaling pathway (GO:0060396)1.99331518
121regulation of voltage-gated calcium channel activity (GO:1901385)1.98555668
122regulation of clathrin-mediated endocytosis (GO:2000369)1.97525456
123regulation of amyloid precursor protein catabolic process (GO:1902991)1.97435825
124synaptic vesicle maturation (GO:0016188)1.97243077
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)1.96786777
126Golgi to endosome transport (GO:0006895)1.95522366
127gamma-aminobutyric acid transport (GO:0015812)1.92892063
128regulation of epidermal growth factor-activated receptor activity (GO:0007176)1.90805344
129positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.90115703
130cytoplasmic mRNA processing body assembly (GO:0033962)1.89664256
131cerebellar Purkinje cell differentiation (GO:0021702)1.89075271
132I-kappaB phosphorylation (GO:0007252)1.89053582
133peptidyl-tyrosine autophosphorylation (GO:0038083)1.88541774
134positive regulation by symbiont of host defense response (GO:0052509)1.88319804
135modulation by symbiont of host defense response (GO:0052031)1.88319804
136modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.88319804
137modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.88319804
138positive regulation by organism of defense response of other organism involved in symbiotic interact1.88319804
139modulation by symbiont of host immune response (GO:0052553)1.88319804
140long-chain fatty acid biosynthetic process (GO:0042759)1.87589372
141positive regulation of potassium ion transmembrane transporter activity (GO:1901018)1.87372362
142platelet-derived growth factor receptor signaling pathway (GO:0048008)1.86776748
143Rap protein signal transduction (GO:0032486)1.81269272
144regulation of cardiac muscle hypertrophy (GO:0010611)1.81098623
145cerebellar granule cell differentiation (GO:0021707)1.81072399
146regulation of T-helper 2 cell differentiation (GO:0045628)1.81028459
147negative regulation of cell killing (GO:0031342)1.80906313
148negative regulation of leukocyte mediated cytotoxicity (GO:0001911)1.80906313
149response to nerve growth factor (GO:1990089)1.80811182
150cellular response to nerve growth factor stimulus (GO:1990090)1.80811182
151negative regulation of hydrogen peroxide-induced cell death (GO:1903206)1.80358842
152relaxation of muscle (GO:0090075)1.80243611
153positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)1.78715557
154myelin maintenance (GO:0043217)1.78704868
155T-helper 1 type immune response (GO:0042088)1.78259300
156dendrite morphogenesis (GO:0048813)1.77275803
157microglial cell activation (GO:0001774)1.76902798
158glutamate receptor signaling pathway (GO:0007215)1.75927557
159regulation of muscle hypertrophy (GO:0014743)1.75317501
160negative regulation of protein localization to cell surface (GO:2000009)1.74949779
161macrophage activation involved in immune response (GO:0002281)1.74023079
162desmosome organization (GO:0002934)1.73942582
163regulation of cellular amide metabolic process (GO:0034248)1.73573413
164ionotropic glutamate receptor signaling pathway (GO:0035235)1.73555687
165receptor catabolic process (GO:0032801)1.72478156
166neuronal action potential propagation (GO:0019227)1.71202313
167positive regulation of potassium ion transport (GO:0043268)1.70379185
168negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)1.70369949
169regulation of p38MAPK cascade (GO:1900744)1.70313210
170positive regulation of p38MAPK cascade (GO:1900745)1.70301773
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)1.70154134
172glycine transport (GO:0015816)1.69537186
173cellular response to growth hormone stimulus (GO:0071378)1.69430041
174negative regulation of T cell mediated immunity (GO:0002710)1.69262313
175adhesion of symbiont to host (GO:0044406)1.68967912
176cellular response to ethanol (GO:0071361)1.68958961
177regulation of ARF protein signal transduction (GO:0032012)1.68441923
178cyclic nucleotide catabolic process (GO:0009214)1.67008055
179mating behavior (GO:0007617)1.66445734
180negative regulation of response to reactive oxygen species (GO:1901032)1.65705323
181positive regulation of protein tyrosine kinase activity (GO:0061098)1.65365862

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.73700329
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.04145495
3MYB_21317192_ChIP-Seq_ERMYB_Mouse2.78735254
4NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.60276222
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47880162
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.42142839
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.37211633
8* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.31170874
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20635436
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.10409683
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07511823
12CDX2_19796622_ChIP-Seq_MESCs_Mouse1.99543045
13GBX2_23144817_ChIP-Seq_PC3_Human1.92759108
14SMAD_19615063_ChIP-ChIP_OVARY_Human1.92012190
15SCL_19346495_ChIP-Seq_HPC-7_Human1.91112553
16MYB_26560356_Chip-Seq_TH2_Human1.83621791
17ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81512912
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80525326
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.70624769
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69797602
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.65840862
22BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62285637
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.57213151
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.54308370
25* TCF7_22412390_ChIP-Seq_EML_Mouse1.54203338
26AR_21572438_ChIP-Seq_LNCaP_Human1.54200016
27SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.53245543
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52279694
29* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.50511386
30* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.50511386
31TP53_16413492_ChIP-PET_HCT116_Human1.49805248
32RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48045310
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46144616
34* MYB_26560356_Chip-Seq_TH1_Human1.45287535
35ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44942480
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.43962323
37VDR_24763502_ChIP-Seq_THP-1_Human1.43508302
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43124179
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42656410
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41541069
41PU_27001747_Chip-Seq_BMDM_Mouse1.40661948
42BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.40630230
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40542916
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40542916
45EZH2_22144423_ChIP-Seq_EOC_Human1.39243603
46SPI1_23127762_ChIP-Seq_K562_Human1.38827963
47VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37580314
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.36832783
49TP53_18474530_ChIP-ChIP_U2OS_Human1.36735716
50DROSHA_22980978_ChIP-Seq_HELA_Human1.36297915
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.35861366
52* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.35422073
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.34425425
54RXR_22108803_ChIP-Seq_LS180_Human1.34032562
55PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33818097
56TP63_17297297_ChIP-ChIP_HaCaT_Human1.33454202
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.33141976
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33137843
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.33060221
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.31447751
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28999135
62STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27831313
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26667309
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.26381352
65SPI1_23547873_ChIP-Seq_NB4_Human1.25657562
66GATA3_27048872_Chip-Seq_THYMUS_Human1.25127702
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24653447
68AHR_22903824_ChIP-Seq_MCF-7_Human1.24519645
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24254845
70SMAD4_21799915_ChIP-Seq_A2780_Human1.23795999
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.22011300
72MAF_26560356_Chip-Seq_TH1_Human1.21583000
73* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21317359
74KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21222251
75GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20205116
76* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19788590
77TAF15_26573619_Chip-Seq_HEK293_Human1.19447751
78* EED_16625203_ChIP-ChIP_MESCs_Mouse1.18770038
79RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.16979768
80GATA1_22025678_ChIP-Seq_K562_Human1.16181238
81RUNX_20019798_ChIP-Seq_JUKART_Human1.16108264
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16011349
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.15551373
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.14791464
85RNF2_27304074_Chip-Seq_ESCs_Mouse1.14395997
86GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14073400
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.13322289
88SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13123463
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.12217873
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12086592
91CJUN_26792858_Chip-Seq_BT549_Human1.11668847
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.11222037
93NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11049266
94* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11018903
95P300_19829295_ChIP-Seq_ESCs_Human1.10992168
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09870815
97WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09814017
98PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09812117
99STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.09060341
100* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08904929
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08850000
102STAT3_23295773_ChIP-Seq_U87_Human1.08364473
103EP300_21415370_ChIP-Seq_HL-1_Mouse1.07962201
104BCAT_22108803_ChIP-Seq_LS180_Human1.06917559
105ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06872271
106SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06135193
107SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06135193
108CLOCK_20551151_ChIP-Seq_293T_Human1.05247688
109GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05053306
110KDM2B_26808549_Chip-Seq_DND41_Human1.04854493
111GATA2_19941826_ChIP-Seq_K562_Human1.04789133
112PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04372299
113KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04310591
114EZH2_27304074_Chip-Seq_ESCs_Mouse1.04267175
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.02610240
116VDR_24787735_ChIP-Seq_THP-1_Human1.02442005
117SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02184900
118WT1_19549856_ChIP-ChIP_CCG9911_Human1.01537818
119AR_25329375_ChIP-Seq_VCAP_Human1.01220706
120STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.01169861
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00987149
122TP63_23658742_ChIP-Seq_EP156T_Human1.00539482
123* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99598671
124CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.99116084
125EZH2_27294783_Chip-Seq_ESCs_Mouse0.98976089
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98931979
127* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97849212
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96793516
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95995775
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95784660
131IRF8_27001747_Chip-Seq_BMDM_Mouse0.95774749
132GATA1_19941826_ChIP-Seq_K562_Human0.95773386
133GATA3_26560356_Chip-Seq_TH2_Human0.95048372
134NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94913893
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94786564
136RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.94532247
137SOX2_27498859_Chip-Seq_STOMACH_Mouse0.94167099
138FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93877090
139GATA1_19941827_ChIP-Seq_MEL_Mouse0.93646980
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93500670
141SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93475001
142FOXA2_19822575_ChIP-Seq_HepG2_Human0.93205993
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.93106064
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93069780
145ESR1_21235772_ChIP-Seq_MCF-7_Human0.92708510
146CTBP1_25329375_ChIP-Seq_LNCAP_Human0.92613679
147NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92114845
148BRD4_25478319_ChIP-Seq_HGPS_Human0.92014756
149PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91240352
150SOX2_20726797_ChIP-Seq_SW620_Human0.91108685
151FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91021806
152* SMAD3_21741376_ChIP-Seq_HESCs_Human0.90811180
153DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90399625
154NANOG_18555785_Chip-Seq_ESCs_Mouse0.90350525
155NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90025420
156VDR_21846776_ChIP-Seq_THP-1_Human0.89892065
157ER_23166858_ChIP-Seq_MCF-7_Human0.89686775
158SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89519140
159KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.88664986
160GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88061750
161TCF4_23295773_ChIP-Seq_U87_Human0.88061360
162TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87150632
163TBX20_22080862_ChIP-Seq_HEART_Mouse0.86390870
164TBX20_22328084_ChIP-Seq_HEART_Mouse0.86390870

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.65218841
2MP0003724_increased_susceptibility_to3.64643039
3MP0001835_abnormal_antigen_presentation2.73566078
4MP0003763_abnormal_thymus_physiology2.66008446
5MP0003690_abnormal_glial_cell2.63225255
6MP0003300_gastrointestinal_ulcer2.59104190
7MP0004859_abnormal_synaptic_plasticity2.51760124
8MP0003436_decreased_susceptibility_to2.49886168
9MP0004270_analgesia2.49780575
10MP0000920_abnormal_myelination2.43567669
11MP0010678_abnormal_skin_adnexa2.37835666
12MP0000465_gastrointestinal_hemorrhage2.24768936
13MP0003045_fibrosis2.16869224
14MP0005000_abnormal_immune_tolerance2.13104158
15MP0003191_abnormal_cellular_cholesterol2.08687324
16MP0003656_abnormal_erythrocyte_physiolo2.03503383
17MP0005167_abnormal_blood-brain_barrier1.97780051
18MP0001800_abnormal_humoral_immune1.94246277
19MP0010352_gastrointestinal_tract_polyps1.92902136
20MP0002254_reproductive_system_inflammat1.91809585
21MP0004885_abnormal_endolymph1.91692419
22MP0005670_abnormal_white_adipose1.91132009
23MP0000685_abnormal_immune_system1.90101149
24MP0002796_impaired_skin_barrier1.89982654
25MP0002419_abnormal_innate_immunity1.89947645
26MP0003195_calcinosis1.88672921
27MP0009780_abnormal_chondrocyte_physiolo1.84199960
28MP0002877_abnormal_melanocyte_morpholog1.74397290
29MP0005409_darkened_coat_color1.69583876
30MP0005025_abnormal_response_to1.69561853
31MP0000569_abnormal_digit_pigmentation1.69398044
32MP0002723_abnormal_immune_serum1.68344463
33MP0002405_respiratory_system_inflammati1.67112616
34MP0002148_abnormal_hypersensitivity_rea1.66105690
35MP0003453_abnormal_keratinocyte_physiol1.65830848
36MP0005464_abnormal_platelet_physiology1.62900127
37MP0002420_abnormal_adaptive_immunity1.62770725
38MP0002452_abnormal_antigen_presenting1.62435987
39MP0004808_abnormal_hematopoietic_stem1.61250194
40MP0002009_preneoplasia1.61235537
41MP0001819_abnormal_immune_cell1.59068032
42MP0001486_abnormal_startle_reflex1.55998173
43MP0010155_abnormal_intestine_physiology1.55217736
44MP0003950_abnormal_plasma_membrane1.53014568
45MP0006054_spinal_hemorrhage1.52684894
46MP0000383_abnormal_hair_follicle1.50805767
47MP0005671_abnormal_response_to1.48815466
48MP0009785_altered_susceptibility_to1.47578484
49MP0003635_abnormal_synaptic_transmissio1.46971085
50MP0002398_abnormal_bone_marrow1.45217318
51MP0005275_abnormal_skin_tensile1.43443276
52MP0003705_abnormal_hypodermis_morpholog1.43408742
53MP0005623_abnormal_meninges_morphology1.40805495
54MP0005171_absent_coat_pigmentation1.39072308
55MP0009745_abnormal_behavioral_response1.38170059
56MP0002064_seizures1.37150991
57MP0004510_myositis1.35524743
58MP0003075_altered_response_to1.35507486
59MP0001533_abnormal_skeleton_physiology1.34076446
60MP0005058_abnormal_lysosome_morphology1.33006026
61MP0005451_abnormal_body_composition1.32001807
62MP0003136_yellow_coat_color1.30317007
63MP0008260_abnormal_autophagy1.29476686
64MP0008004_abnormal_stomach_pH1.29214688
65MP0003633_abnormal_nervous_system1.28399992
66MP0002138_abnormal_hepatobiliary_system1.27626878
67MP0000716_abnormal_immune_system1.26707555
68MP0003252_abnormal_bile_duct1.25495756
69MP0008057_abnormal_DNA_replication1.23862772
70MP0005076_abnormal_cell_differentiation1.23321564
71MP0000604_amyloidosis1.22401556
72MP0003634_abnormal_glial_cell1.21757089
73MP0001851_eye_inflammation1.21555268
74MP0009046_muscle_twitch1.21083090
75MP0001845_abnormal_inflammatory_respons1.20502503
76MP0001501_abnormal_sleep_pattern1.20385195
77MP0009764_decreased_sensitivity_to1.19890798
78MP0004947_skin_inflammation1.17452362
79MP0000858_altered_metastatic_potential1.16920522
80MP0005310_abnormal_salivary_gland1.16344978
81MP0002396_abnormal_hematopoietic_system1.14929159
82MP0004883_abnormal_blood_vessel1.14660337
83MP0005397_hematopoietic_system_phenotyp1.14414080
84MP0001545_abnormal_hematopoietic_system1.14414080
85MP0002722_abnormal_immune_system1.12010802
86MP0000689_abnormal_spleen_morphology1.11619611
87MP0001440_abnormal_grooming_behavior1.11502923
88MP0004185_abnormal_adipocyte_glucose1.10703546
89MP0005166_decreased_susceptibility_to1.10410066
90MP0002060_abnormal_skin_morphology1.09664413
91MP0004130_abnormal_muscle_cell1.09189207
92MP0005164_abnormal_response_to1.08778890
93MP0003329_amyloid_beta_deposits1.07019965
94MP0002971_abnormal_brown_adipose1.05972633
95MP0002998_abnormal_bone_remodeling1.05207377
96MP0002896_abnormal_bone_mineralization1.04882684
97MP0000703_abnormal_thymus_morphology1.04721708
98MP0000249_abnormal_blood_vessel1.02415188
99MP0002272_abnormal_nervous_system1.01984698
100MP0004742_abnormal_vestibular_system1.01457147
101MP0002098_abnormal_vibrissa_morphology1.01265982
102MP0003279_aneurysm1.01196773
103MP0003448_altered_tumor_morphology1.01144355
104MP0005375_adipose_tissue_phenotype1.00841567
105MP0002063_abnormal_learning/memory/cond0.99131610
106MP0003566_abnormal_cell_adhesion0.99015223
107MP0003091_abnormal_cell_migration0.99010627
108MP0004484_altered_response_of0.98074010
109MP0004272_abnormal_basement_membrane0.97750011
110MP0000003_abnormal_adipose_tissue0.97546886
111MP0008569_lethality_at_weaning0.97324009
112MP0009384_cardiac_valve_regurgitation0.97323047
113MP0001177_atelectasis0.96608983
114MP0001299_abnormal_eye_distance/0.95767295
115MP0003631_nervous_system_phenotype0.95705628
116MP0002429_abnormal_blood_cell0.95498602
117MP0003172_abnormal_lysosome_physiology0.94939011
118MP0004145_abnormal_muscle_electrophysio0.94349279
119MP0003866_abnormal_defecation0.93660474
120MP0002332_abnormal_exercise_endurance0.93639285
121MP0006082_CNS_inflammation0.93485283
122MP0002572_abnormal_emotion/affect_behav0.93394531
123MP0005387_immune_system_phenotype0.93352662
124MP0001790_abnormal_immune_system0.93352662
125MP0002734_abnormal_mechanical_nocicepti0.91624573
126MP0009333_abnormal_splenocyte_physiolog0.91560195
127MP0001853_heart_inflammation0.91251950
128MP0005666_abnormal_adipose_tissue0.91133510
129MP0000767_abnormal_smooth_muscle0.90007422
130MP0010368_abnormal_lymphatic_system0.88561534
131MP0003828_pulmonary_edema0.88484781
132MP0002006_tumorigenesis0.87917678
133MP0002168_other_aberrant_phenotype0.87789074
134MP0000427_abnormal_hair_cycle0.87411850
135MP0001958_emphysema0.86932098
136MP0010771_integument_phenotype0.86697494
137MP0001485_abnormal_pinna_reflex0.85673534
138MP0001216_abnormal_epidermal_layer0.85510007
139MP0003183_abnormal_peptide_metabolism0.83583448
140MP0008469_abnormal_protein_level0.82683188
141MP0008438_abnormal_cutaneous_collagen0.82550989
142MP0000377_abnormal_hair_follicle0.82541885
143MP0005388_respiratory_system_phenotype0.82529366
144MP0002133_abnormal_respiratory_system0.82529366
145MP0003632_abnormal_nervous_system0.82176972
146MP0003221_abnormal_cardiomyocyte_apopto0.81412526
147MP0001765_abnormal_ion_homeostasis0.79768239
148MP0009115_abnormal_fat_cell0.79545946
149MP0002166_altered_tumor_susceptibility0.78876774
150MP0000343_altered_response_to0.78692955
151MP0008874_decreased_physiological_sensi0.77842081
152MP0001879_abnormal_lymphatic_vessel0.77022451
153MP0000747_muscle_weakness0.76896199
154MP0003880_abnormal_central_pattern0.76438089
155MP0000647_abnormal_sebaceous_gland0.76174843
156MP0000579_abnormal_nail_morphology0.75198392
157MP0003303_peritoneal_inflammation0.75086608
158MP0004043_abnormal_pH_regulation0.73588987
159MP0002090_abnormal_vision0.73164903
160MP0002295_abnormal_pulmonary_circulatio0.72447033

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)3.50310089
2Recurrent abscess formation (HP:0002722)3.30333140
3Spontaneous hematomas (HP:0007420)3.29800755
4Action tremor (HP:0002345)3.19826376
5Neurofibrillary tangles (HP:0002185)3.06513878
6Myositis (HP:0100614)3.00880461
7Aortic aneurysm (HP:0004942)2.90515915
8Orchitis (HP:0100796)2.88955598
9T lymphocytopenia (HP:0005403)2.76821247
10Retrobulbar optic neuritis (HP:0100654)2.76541076
11Optic neuritis (HP:0100653)2.76541076
12Onion bulb formation (HP:0003383)2.66794076
13Aplasia involving bones of the upper limbs (HP:0009823)2.64454112
14Aplasia of the phalanges of the hand (HP:0009802)2.64454112
15Aplasia involving bones of the extremities (HP:0009825)2.64454112
16Gingivitis (HP:0000230)2.64252720
17Abnormality of T cell number (HP:0011839)2.63378204
18Hyporeflexia of lower limbs (HP:0002600)2.57141962
19Sensory axonal neuropathy (HP:0003390)2.56931166
20Hematochezia (HP:0002573)2.56485611
21Follicular hyperkeratosis (HP:0007502)2.55516464
22Keratoconjunctivitis sicca (HP:0001097)2.53945967
23Abnormality of macrophages (HP:0004311)2.51405179
24Intention tremor (HP:0002080)2.50744139
25Cerebral inclusion bodies (HP:0100314)2.49428738
26Hypoplastic ischia (HP:0003175)2.48694565
27Papilledema (HP:0001085)2.47990133
28Thick nail (HP:0001805)2.47635048
29Abnormality of the ischium (HP:0003174)2.45993413
30Cellulitis (HP:0100658)2.45297127
31Gastrointestinal infarctions (HP:0005244)2.43961076
32Recurrent gram-negative bacterial infections (HP:0005420)2.40736697
33Degeneration of the lateral corticospinal tracts (HP:0002314)2.40734106
34Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.40734106
35Recurrent skin infections (HP:0001581)2.39194455
36Abnormality of binocular vision (HP:0011514)2.36701817
37Diplopia (HP:0000651)2.36701817
38Papillary thyroid carcinoma (HP:0002895)2.36429423
39Myocardial infarction (HP:0001658)2.35925629
40Broad metatarsal (HP:0001783)2.35338441
41Focal motor seizures (HP:0011153)2.34076331
42Hypoplasia of the iris (HP:0007676)2.34016137
43Prolonged bleeding time (HP:0003010)2.33448804
44Autoimmune hemolytic anemia (HP:0001890)2.32598957
45Increased CSF protein (HP:0002922)2.31801810
46Mediastinal lymphadenopathy (HP:0100721)2.31740604
47Increased IgE level (HP:0003212)2.30145577
48Keratoconjunctivitis (HP:0001096)2.27794332
49Gingival bleeding (HP:0000225)2.25336198
50Subacute progressive viral hepatitis (HP:0006572)2.23739289
51Dilatation of the ascending aorta (HP:0005111)2.22214470
52Recurrent fungal infections (HP:0002841)2.17393519
53Vasculitis (HP:0002633)2.15959022
54Spinal cord lesions (HP:0100561)2.15446252
55Syringomyelia (HP:0003396)2.15446252
56Osteomyelitis (HP:0002754)2.15204405
57Metabolic alkalosis (HP:0200114)2.15035468
58Exercise-induced myalgia (HP:0003738)2.13937539
59Supranuclear gaze palsy (HP:0000605)2.13238162
60Increased circulating renin level (HP:0000848)2.12740106
61Termporal pattern (HP:0011008)2.12439967
62Insidious onset (HP:0003587)2.12439967
63Recurrent viral infections (HP:0004429)2.10712117
64Inflammation of the large intestine (HP:0002037)2.09779447
65Interstitial pulmonary disease (HP:0006530)2.09413475
66Focal seizures (HP:0007359)2.08991308
67Gastrointestinal inflammation (HP:0004386)2.06205641
68Abnormal delayed hypersensitivity skin test (HP:0002963)2.05960654
69Axonal loss (HP:0003447)2.05481443
70Colitis (HP:0002583)2.05052457
71Febrile seizures (HP:0002373)2.02955694
72Chest pain (HP:0100749)2.02547078
73Dysmetria (HP:0001310)2.01943924
74Elevated erythrocyte sedimentation rate (HP:0003565)2.00913054
75Abnormality of the corticospinal tract (HP:0002492)2.00787372
76Abnormal platelet volume (HP:0011876)1.99785601
77Epistaxis (HP:0000421)1.98857951
78Milia (HP:0001056)1.98736281
79Progressive cerebellar ataxia (HP:0002073)1.98053937
80Postural instability (HP:0002172)1.98049718
81Arterial thrombosis (HP:0004420)1.96553652
82Meningitis (HP:0001287)1.95823129
83Difficulty running (HP:0009046)1.95524002
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95450351
85Dysmetric saccades (HP:0000641)1.95318189
86Clumsiness (HP:0002312)1.94966166
87Pulmonary infiltrates (HP:0002113)1.94572661
88Lower limb amyotrophy (HP:0007210)1.94293443
89Alopecia of scalp (HP:0002293)1.93569074
90Arterial tortuosity (HP:0005116)1.93164347
91Macroorchidism (HP:0000053)1.90805691
92Enlarged epiphyses (HP:0010580)1.90353246
93Increased cerebral lipofuscin (HP:0011813)1.90265976
94Hypoplastic labia majora (HP:0000059)1.90227460
95Distal lower limb amyotrophy (HP:0008944)1.89458405
96Mitral valve prolapse (HP:0001634)1.89079977
97Dysdiadochokinesis (HP:0002075)1.86321208
98Mixed hearing impairment (HP:0000410)1.85950102
99Slow saccadic eye movements (HP:0000514)1.85370987
100Eczematoid dermatitis (HP:0000976)1.82694273
101Recurrent cutaneous fungal infections (HP:0011370)1.82000202
102Chronic mucocutaneous candidiasis (HP:0002728)1.82000202
103Blue irides (HP:0000635)1.80920212
104Gaze-evoked nystagmus (HP:0000640)1.80848295
105Anteriorly placed anus (HP:0001545)1.80608160
106Viral hepatitis (HP:0006562)1.80349075
107Asymmetric septal hypertrophy (HP:0001670)1.79631406
108Hemoptysis (HP:0002105)1.79609515
109Absent frontal sinuses (HP:0002688)1.79249015
110Neoplasm of the tracheobronchial system (HP:0100552)1.78964124
111Aneurysm (HP:0002617)1.78219836
112Abnormality of the left ventricular outflow tract (HP:0011103)1.78162111
113Subaortic stenosis (HP:0001682)1.78162111
114Cerebral hemorrhage (HP:0001342)1.77517335
115Hyperkalemia (HP:0002153)1.77500406
116Recurrent bronchitis (HP:0002837)1.75762426
117Stomatitis (HP:0010280)1.75713630
118Peritonitis (HP:0002586)1.75243707
119Spondylolisthesis (HP:0003302)1.74799005
120Increased variability in muscle fiber diameter (HP:0003557)1.74256435
121Chronic diarrhea (HP:0002028)1.74130454
122Increased mean platelet volume (HP:0011877)1.72609715
123Testicular atrophy (HP:0000029)1.72534675
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.72347420
125Osteolytic defects of the hand bones (HP:0009699)1.72347420
126Urticaria (HP:0001025)1.71864287
127Vascular tortuosity (HP:0004948)1.71209291
128Abnormality of the labia majora (HP:0012881)1.70705950
129Epileptic encephalopathy (HP:0200134)1.70475644
130Widely spaced teeth (HP:0000687)1.69642738
131Scapular winging (HP:0003691)1.69510353
132Abnormality of the fingertips (HP:0001211)1.69348906
133Steppage gait (HP:0003376)1.68831777
134Curly hair (HP:0002212)1.68478984
135Increased neuronal autofluorescent lipopigment (HP:0002074)1.68314451
136Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.68203434
137Aortic dissection (HP:0002647)1.68180095
138Pulmonary embolism (HP:0002204)1.68179018
139Encephalitis (HP:0002383)1.67657466
140Fatigue (HP:0012378)1.67482816
141Overgrowth (HP:0001548)1.67358428
142EMG: myopathic abnormalities (HP:0003458)1.66762852
143Atonic seizures (HP:0010819)1.66563143
144Muscle hypertrophy of the lower extremities (HP:0008968)1.66469604
145Foot dorsiflexor weakness (HP:0009027)1.66456268
146Dysostosis multiplex (HP:0000943)1.66423611
147Genetic anticipation (HP:0003743)1.66220625
148Increased connective tissue (HP:0009025)1.66175838
149Gastrointestinal stroma tumor (HP:0100723)1.65191289
150Truncal ataxia (HP:0002078)1.65083877
151Urinary bladder sphincter dysfunction (HP:0002839)1.64184105
152Abnormality of skeletal muscle fiber size (HP:0012084)1.64103562
153Peripheral demyelination (HP:0011096)1.63857598
154Amyloidosis (HP:0011034)1.63797222
155Ectropion (HP:0000656)1.63476983
156Cerebral aneurysm (HP:0004944)1.62758552
157Scanning speech (HP:0002168)1.61922880
158Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.61359967
159Abnormality of the peritoneum (HP:0002585)1.61225116
160Choroideremia (HP:0001139)1.61179044
161Abnormality of T cells (HP:0002843)1.61085957
162Hypophosphatemic rickets (HP:0004912)1.61010571
163Coarse hair (HP:0002208)1.60603852
164Vertebral arch anomaly (HP:0008438)1.60087932
165Resting tremor (HP:0002322)1.60049418
166Megalencephaly (HP:0001355)1.60011999
167Thyroid carcinoma (HP:0002890)1.59869788
168Periodontitis (HP:0000704)1.59644086
169Postural tremor (HP:0002174)1.58833757
170Malnutrition (HP:0004395)1.58570232
171Parakeratosis (HP:0001036)1.55584527
172Thickened helices (HP:0000391)1.55297826
173Generalized tonic-clonic seizures (HP:0002069)1.55170705
174Bronchomalacia (HP:0002780)1.54271616
175Calf muscle hypertrophy (HP:0008981)1.54190518
176Autoimmune thrombocytopenia (HP:0001973)1.54114617
177Status epilepticus (HP:0002133)1.52184359
178Oligodactyly (hands) (HP:0001180)1.49825726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.43053781
2TNIK3.42414743
3MKNK22.69803509
4RIPK12.56013508
5STK392.52784640
6MAP3K22.37632562
7RIPK42.11621617
8MAP2K32.07231853
9EPHB11.98092785
10MAP3K141.90886946
11TYK21.85277720
12OXSR11.84909163
13MAP4K11.82509854
14CDK121.74203083
15WNK11.72731008
16NEK91.61423376
17IRAK31.59171149
18FES1.58336614
19MAP3K61.57873954
20FGFR21.54876080
21BLK1.52928610
22ZAP701.52693502
23BRD41.44831577
24YES11.43471102
25EPHA41.41188392
26ERN11.40917860
27PIK3CG1.38112180
28INSRR1.37562116
29TRPM71.36595506
30MAP3K91.33099537
31IRAK41.30965194
32MAP3K131.30834026
33TGFBR21.30800164
34MST41.30471307
35IRAK21.29929593
36LATS11.28925812
37KSR21.28244769
38NTRK31.27127658
39BTK1.25168525
40CDK61.23959100
41SCYL21.23622691
42AKT31.23316837
43PKN11.20040275
44STK241.19804909
45SYK1.18450402
46FGFR31.18078112
47JAK31.16783792
48ACVR1B1.16442891
49WNK41.14898211
50TAOK31.14326568
51FRK1.11824813
52TBK11.09461611
53JAK11.09310480
54NTRK11.05510326
55CAMK1G1.01218753
56SGK31.00632024
57DAPK21.00390717
58ITK0.99715651
59TXK0.99176041
60PRKG20.96771732
61FER0.96306906
62TEC0.95483010
63SGK4940.94768087
64SGK2230.94768087
65MKNK10.93914978
66IRAK10.93704712
67PAK30.93378459
68PRKCH0.92433412
69DMPK0.91467315
70PHKG20.91361434
71PHKG10.91361434
72MAPK150.87668127
73MET0.87611324
74PTK60.87514897
75PRKCQ0.85962392
76EPHA30.84795014
77HIPK20.84139740
78BMX0.84060342
79GRK60.82777330
80PAK60.82764655
81SGK10.82280093
82FGR0.82278502
83GRK50.81464990
84STK30.80575614
85MAPK70.76950982
86MAP3K30.76389739
87RET0.76340632
88JAK20.76333115
89PDGFRB0.76183035
90CAMK1D0.75678469
91TTN0.75543049
92LCK0.75331429
93PRKCE0.74562754
94BMPR20.74372715
95MAP3K10.73810256
96MAP3K70.73794918
97PDPK10.71887536
98MAPKAPK50.70868541
99MAPK120.70395169
100MARK20.70270124
101IKBKE0.70266476
102STK110.69867978
103PDGFRA0.69167351
104PDK10.69004819
105RAF10.68982252
106NEK60.68828740
107LYN0.68049943
108CSF1R0.66902332
109IKBKB0.66236903
110CAMKK10.66129948
111SGK20.65308412
112PRKD10.63617498
113SIK10.63566156
114GRK70.63495844
115KIT0.63457577
116CDK50.63180542
117HCK0.62873772
118PRKD20.62113518
119MAP3K40.60589171
120STK380.59310144
121CAMK2B0.59187709
122MATK0.59102858
123EEF2K0.58963080
124ERBB30.58781321
125PTK20.58445314
126MAP2K40.58404591
127CAMKK20.58377150
128TNK20.57178699
129PRKAA20.55793799
130NLK0.55635701
131FYN0.55386379
132GSK3A0.54930260
133STK100.53381847
134CAMK2D0.53237245
135TAOK10.52711717
136PIM10.52523090
137TYRO30.51789453
138DDR20.51350340
139MAP3K50.50552114
140FGFR40.50379872
141PINK10.48892579
142MAPK110.48543886
143PIK3CA0.48540702
144CAMK2A0.47235670
145MOS0.46060780
146MELK0.45941299
147STK38L0.45937277
148CSK0.45820364

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.12801571
2Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.47132573
3Acute myeloid leukemia_Homo sapiens_hsa052211.46006347
4Chronic myeloid leukemia_Homo sapiens_hsa052201.44985634
5Long-term potentiation_Homo sapiens_hsa047201.44538923
6Jak-STAT signaling pathway_Homo sapiens_hsa046301.42718592
7Non-small cell lung cancer_Homo sapiens_hsa052231.41933895
8Pancreatic cancer_Homo sapiens_hsa052121.41047577
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38561350
10Renin secretion_Homo sapiens_hsa049241.38375124
11Measles_Homo sapiens_hsa051621.36204853
12Dorso-ventral axis formation_Homo sapiens_hsa043201.35850480
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.35571140
14Salivary secretion_Homo sapiens_hsa049701.35569687
15Gastric acid secretion_Homo sapiens_hsa049711.31815544
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30950126
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28744372
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28518690
19Toxoplasmosis_Homo sapiens_hsa051451.27284798
20Glutamatergic synapse_Homo sapiens_hsa047241.26323510
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.24328425
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.22517243
23Prolactin signaling pathway_Homo sapiens_hsa049171.20848357
24Hepatitis B_Homo sapiens_hsa051611.19382437
25Amphetamine addiction_Homo sapiens_hsa050311.16403803
26GABAergic synapse_Homo sapiens_hsa047271.16185236
27Circadian entrainment_Homo sapiens_hsa047131.15453254
28Long-term depression_Homo sapiens_hsa047301.13062653
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12925574
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.12871715
31Phosphatidylinositol signaling system_Homo sapiens_hsa040701.10882424
32Influenza A_Homo sapiens_hsa051641.09996131
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.09523815
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08641137
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07136928
36Osteoclast differentiation_Homo sapiens_hsa043801.06508872
37Morphine addiction_Homo sapiens_hsa050321.06218835
38FoxO signaling pathway_Homo sapiens_hsa040681.05819445
39Hepatitis C_Homo sapiens_hsa051601.04900740
40Insulin secretion_Homo sapiens_hsa049111.04339868
41Hematopoietic cell lineage_Homo sapiens_hsa046401.01423308
42Type II diabetes mellitus_Homo sapiens_hsa049301.00633130
43Cholinergic synapse_Homo sapiens_hsa047250.98298618
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97588056
45Endometrial cancer_Homo sapiens_hsa052130.97013890
46Oxytocin signaling pathway_Homo sapiens_hsa049210.95989899
47Olfactory transduction_Homo sapiens_hsa047400.95255565
48Legionellosis_Homo sapiens_hsa051340.94856196
49cAMP signaling pathway_Homo sapiens_hsa040240.94301238
50Cocaine addiction_Homo sapiens_hsa050300.93694370
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91409004
52ECM-receptor interaction_Homo sapiens_hsa045120.90576701
53Dilated cardiomyopathy_Homo sapiens_hsa054140.88842849
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88807650
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.86196278
56Nicotine addiction_Homo sapiens_hsa050330.85871769
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85841665
58African trypanosomiasis_Homo sapiens_hsa051430.84876381
59GnRH signaling pathway_Homo sapiens_hsa049120.84545221
60Graft-versus-host disease_Homo sapiens_hsa053320.84214438
61Herpes simplex infection_Homo sapiens_hsa051680.84019483
62Mineral absorption_Homo sapiens_hsa049780.83928115
63Calcium signaling pathway_Homo sapiens_hsa040200.83398747
64Prostate cancer_Homo sapiens_hsa052150.82476223
65Thyroid hormone synthesis_Homo sapiens_hsa049180.82033261
66Tuberculosis_Homo sapiens_hsa051520.81606826
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81146594
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.80964883
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.80883043
70Dopaminergic synapse_Homo sapiens_hsa047280.80140826
71Staphylococcus aureus infection_Homo sapiens_hsa051500.79841589
72Amoebiasis_Homo sapiens_hsa051460.79148729
73Renal cell carcinoma_Homo sapiens_hsa052110.78891640
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.78374616
75Estrogen signaling pathway_Homo sapiens_hsa049150.78266986
76Apoptosis_Homo sapiens_hsa042100.77796463
77Bile secretion_Homo sapiens_hsa049760.77317066
78Pancreatic secretion_Homo sapiens_hsa049720.76385610
79Melanogenesis_Homo sapiens_hsa049160.75651650
80Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75598219
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75389112
82Serotonergic synapse_Homo sapiens_hsa047260.74833306
83Choline metabolism in cancer_Homo sapiens_hsa052310.73625147
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73585928
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73393861
86Chemokine signaling pathway_Homo sapiens_hsa040620.72559313
87Other glycan degradation_Homo sapiens_hsa005110.71742622
88TNF signaling pathway_Homo sapiens_hsa046680.71496520
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71153475
90B cell receptor signaling pathway_Homo sapiens_hsa046620.71081202
91Rheumatoid arthritis_Homo sapiens_hsa053230.70613186
92Malaria_Homo sapiens_hsa051440.69713963
93Axon guidance_Homo sapiens_hsa043600.69587343
94* Circadian rhythm_Homo sapiens_hsa047100.68922336
95Viral carcinogenesis_Homo sapiens_hsa052030.68375641
96Colorectal cancer_Homo sapiens_hsa052100.68196270
97Inositol phosphate metabolism_Homo sapiens_hsa005620.67443071
98Insulin signaling pathway_Homo sapiens_hsa049100.66873427
99Endocytosis_Homo sapiens_hsa041440.66286559
100Type I diabetes mellitus_Homo sapiens_hsa049400.66221353
101Insulin resistance_Homo sapiens_hsa049310.65744463
102Intestinal immune network for IgA production_Homo sapiens_hsa046720.65282433
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.65189442
104Small cell lung cancer_Homo sapiens_hsa052220.64990475
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64481866
106ErbB signaling pathway_Homo sapiens_hsa040120.64311603
107Autoimmune thyroid disease_Homo sapiens_hsa053200.63812456
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63798284
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63797029
110MAPK signaling pathway_Homo sapiens_hsa040100.63376810
111Sphingolipid metabolism_Homo sapiens_hsa006000.62716634
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.62243487
113Focal adhesion_Homo sapiens_hsa045100.62059484
114Shigellosis_Homo sapiens_hsa051310.62043369
115Salmonella infection_Homo sapiens_hsa051320.61928380
116Platelet activation_Homo sapiens_hsa046110.61108040
117Primary immunodeficiency_Homo sapiens_hsa053400.61096641
118Proteoglycans in cancer_Homo sapiens_hsa052050.61064556
119Fatty acid biosynthesis_Homo sapiens_hsa000610.60299530
120Ras signaling pathway_Homo sapiens_hsa040140.60091823
121Glioma_Homo sapiens_hsa052140.59909345
122Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59514694
123Viral myocarditis_Homo sapiens_hsa054160.58758998
124Lysosome_Homo sapiens_hsa041420.58607356
125Taste transduction_Homo sapiens_hsa047420.57844027
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57676967
127Leishmaniasis_Homo sapiens_hsa051400.57390499
128Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57324067
129Ovarian steroidogenesis_Homo sapiens_hsa049130.57258573
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.56022442
131Phagosome_Homo sapiens_hsa041450.55974778
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55288216
133Pertussis_Homo sapiens_hsa051330.55236740
134T cell receptor signaling pathway_Homo sapiens_hsa046600.54850467
135HTLV-I infection_Homo sapiens_hsa051660.54772641
136Rap1 signaling pathway_Homo sapiens_hsa040150.54758152
137RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54330578
138ABC transporters_Homo sapiens_hsa020100.54168960
139Collecting duct acid secretion_Homo sapiens_hsa049660.53067217
140Allograft rejection_Homo sapiens_hsa053300.52855071
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51612077
142MicroRNAs in cancer_Homo sapiens_hsa052060.51315097
143VEGF signaling pathway_Homo sapiens_hsa043700.51089642
144Synaptic vesicle cycle_Homo sapiens_hsa047210.50871439
145mTOR signaling pathway_Homo sapiens_hsa041500.50639144

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