FBXL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family, which are characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one subunit of modular E3 ubiquitin ligase complexes, called SCF complexes, which function in phosphorylation-dependent ubiquitination. The F-box domain mediates protein-protein interactions and binds directly to S-phase kinase-associated protein 1. In addition to an F-box domain, the encoded protein contains at least 9 tandem leucine-rich repeats. The ubiquitin ligase complex containing the encoded protein may function in cell-cycle control by regulating levels of lysine-specific demethylase 4A. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.90813742
2L-phenylalanine catabolic process (GO:0006559)5.90813742
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.50865761
4L-phenylalanine metabolic process (GO:0006558)5.50865761
5interkinetic nuclear migration (GO:0022027)5.18216978
6phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.93980199
7aromatic amino acid family catabolic process (GO:0009074)4.71195062
8negative regulation of complement activation (GO:0045916)4.21073031
9bile acid biosynthetic process (GO:0006699)4.10990241
10urea cycle (GO:0000050)4.05685275
11urea metabolic process (GO:0019627)4.05685275
12alpha-linolenic acid metabolic process (GO:0036109)4.00953835
13negative regulation of protein activation cascade (GO:2000258)4.00828139
14lysine catabolic process (GO:0006554)4.00198399
15lysine metabolic process (GO:0006553)4.00198399
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.95269014
17establishment of protein localization to Golgi (GO:0072600)3.94616518
18sulfur amino acid catabolic process (GO:0000098)3.84791581
19phospholipid translocation (GO:0045332)3.84279695
20lipid translocation (GO:0034204)3.84279695
21glyoxylate metabolic process (GO:0046487)3.81079278
22cysteine metabolic process (GO:0006534)3.79505315
23monoubiquitinated protein deubiquitination (GO:0035520)3.77892669
24nitrogen cycle metabolic process (GO:0071941)3.73010898
25Golgi transport vesicle coating (GO:0048200)3.69534660
26COPI coating of Golgi vesicle (GO:0048205)3.69534660
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.66227492
28tyrosine metabolic process (GO:0006570)3.66121985
29tryptophan catabolic process (GO:0006569)3.64402141
30indole-containing compound catabolic process (GO:0042436)3.64402141
31indolalkylamine catabolic process (GO:0046218)3.64402141
32valine metabolic process (GO:0006573)3.63819043
33protein K11-linked deubiquitination (GO:0035871)3.61532579
34tryptophan metabolic process (GO:0006568)3.60248448
35short-chain fatty acid metabolic process (GO:0046459)3.59849977
36response to nitrosative stress (GO:0051409)3.55749767
37cellular glucuronidation (GO:0052695)3.53961613
38cellular ketone body metabolic process (GO:0046950)3.52200577
39high-density lipoprotein particle remodeling (GO:0034375)3.51008551
40fatty acid beta-oxidation (GO:0006635)3.49976699
41aromatic amino acid family metabolic process (GO:0009072)3.45864047
42bile acid metabolic process (GO:0008206)3.44048221
43cellular response to ethanol (GO:0071361)3.43675427
44complement activation, alternative pathway (GO:0006957)3.40219056
45fatty acid catabolic process (GO:0009062)3.40067405
46biotin metabolic process (GO:0006768)3.35974913
47retrograde transport, vesicle recycling within Golgi (GO:0000301)3.35532626
48protein targeting to Golgi (GO:0000042)3.35488882
49fatty acid oxidation (GO:0019395)3.35088866
50neural tube formation (GO:0001841)3.34799477
51uronic acid metabolic process (GO:0006063)3.32230589
52glucuronate metabolic process (GO:0019585)3.32230589
53monocarboxylic acid catabolic process (GO:0072329)3.31196032
54coenzyme catabolic process (GO:0009109)3.29515066
55positive regulation of muscle hypertrophy (GO:0014742)3.28878976
56positive regulation of cardiac muscle hypertrophy (GO:0010613)3.28878976
57succinate metabolic process (GO:0006105)3.27114820
58lipid oxidation (GO:0034440)3.27038373
59kynurenine metabolic process (GO:0070189)3.26788074
602-oxoglutarate metabolic process (GO:0006103)3.26666073
61labyrinthine layer development (GO:0060711)3.25448641
62nucleus localization (GO:0051647)3.25373237
63alpha-amino acid catabolic process (GO:1901606)3.24707896
64homocysteine metabolic process (GO:0050667)3.23381004
65protein localization to Golgi apparatus (GO:0034067)3.22723131
66branched-chain amino acid catabolic process (GO:0009083)3.22614212
67acylglycerol homeostasis (GO:0055090)3.19771091
68triglyceride homeostasis (GO:0070328)3.19771091
69early endosome to late endosome transport (GO:0045022)3.18427903
70negative regulation of fibrinolysis (GO:0051918)3.17604861
71reverse cholesterol transport (GO:0043691)3.14719108
72acyl-CoA biosynthetic process (GO:0071616)3.13969953
73thioester biosynthetic process (GO:0035384)3.13969953
74Golgi to endosome transport (GO:0006895)3.13833177
75cellular amino acid catabolic process (GO:0009063)3.13272597
76carnitine transmembrane transport (GO:1902603)3.12647463
77regulation of establishment of cell polarity (GO:2000114)3.11915554
78phospholipid efflux (GO:0033700)3.11787310
79positive regulation of developmental pigmentation (GO:0048087)3.11687093
80amino-acid betaine transport (GO:0015838)3.11546603
81carnitine transport (GO:0015879)3.11546603
82ether lipid metabolic process (GO:0046485)3.10561268
83regulation of triglyceride catabolic process (GO:0010896)3.09889892
84cytoplasmic mRNA processing body assembly (GO:0033962)3.09112990
85thrombin receptor signaling pathway (GO:0070493)3.09060287
86acetyl-CoA metabolic process (GO:0006084)3.08895276
87branched-chain amino acid metabolic process (GO:0009081)3.08524619
88fatty-acyl-CoA biosynthetic process (GO:0046949)3.08509287
89regulation of pigment cell differentiation (GO:0050932)3.08067809
90regulation of protein activation cascade (GO:2000257)3.07910061
91pericardium development (GO:0060039)3.07353666
92neutral lipid catabolic process (GO:0046461)3.06716725
93acylglycerol catabolic process (GO:0046464)3.06716725
94ketone body metabolic process (GO:1902224)3.05070753
95prenylation (GO:0097354)3.04342028
96protein prenylation (GO:0018342)3.04342028
97organic acid catabolic process (GO:0016054)3.04277622
98carboxylic acid catabolic process (GO:0046395)3.04277622
99triglyceride catabolic process (GO:0019433)3.03795174
100xenobiotic catabolic process (GO:0042178)3.01307146
101toxin transport (GO:1901998)3.01076337
102positive regulation of fatty acid beta-oxidation (GO:0032000)3.00521317
103negative regulation of neurotransmitter transport (GO:0051589)2.99484754
104positive regulation of fatty acid oxidation (GO:0046321)2.98477581
105macroautophagy (GO:0016236)2.97685816
106oxaloacetate metabolic process (GO:0006107)2.97156826
107peptidyl-glutamic acid carboxylation (GO:0017187)2.96825948
108protein carboxylation (GO:0018214)2.96825948
109regulation of acyl-CoA biosynthetic process (GO:0050812)2.96567560
110phospholipid homeostasis (GO:0055091)2.96127257
111aspartate family amino acid catabolic process (GO:0009068)2.94857329
112myelin assembly (GO:0032288)2.94654690
113intestinal cholesterol absorption (GO:0030299)2.94018361
114regulation of fibrinolysis (GO:0051917)2.93664130
115negative regulation of humoral immune response (GO:0002921)2.93370904
116regulation of Golgi to plasma membrane protein transport (GO:0042996)2.92298230
117drug metabolic process (GO:0017144)2.92022016
118regulation of complement activation (GO:0030449)2.90007128
119regulation of protein polyubiquitination (GO:1902914)2.89821647
120benzene-containing compound metabolic process (GO:0042537)2.87354384
121regulation of cholesterol esterification (GO:0010872)2.87052595
122regulation of protein glycosylation (GO:0060049)2.86481947
123drug catabolic process (GO:0042737)2.86365991
124serine family amino acid catabolic process (GO:0009071)2.84437194
125long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.83566014
126glutamate metabolic process (GO:0006536)2.83431456
127COPII vesicle coating (GO:0048208)2.83322958
128protein targeting to vacuole (GO:0006623)2.83026649
129protein targeting to lysosome (GO:0006622)2.83026649
130establishment of protein localization to vacuole (GO:0072666)2.83026649
131fibroblast migration (GO:0010761)2.82998070
132cellular modified amino acid catabolic process (GO:0042219)2.82747985
133aldehyde catabolic process (GO:0046185)2.82691919
134microtubule anchoring (GO:0034453)2.82566680
135intra-Golgi vesicle-mediated transport (GO:0006891)2.82142104
136fatty-acyl-CoA metabolic process (GO:0035337)2.81846401
137indolalkylamine metabolic process (GO:0006586)2.81246040
138protein-lipid complex remodeling (GO:0034368)2.80669164
139macromolecular complex remodeling (GO:0034367)2.80669164
140plasma lipoprotein particle remodeling (GO:0034369)2.80669164
141ethanol oxidation (GO:0006069)2.79824939
142amino-acid betaine metabolic process (GO:0006577)2.79777112
143plasma lipoprotein particle clearance (GO:0034381)2.78021909
144regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.76904580
145NADH metabolic process (GO:0006734)2.75341466
146embryonic retina morphogenesis in camera-type eye (GO:0060059)2.74150373
147flavonoid metabolic process (GO:0009812)2.73075789
148regulation of cholesterol biosynthetic process (GO:0045540)2.72886322
149acyl-CoA metabolic process (GO:0006637)2.72002256
150thioester metabolic process (GO:0035383)2.72002256
151positive regulation of granulocyte differentiation (GO:0030854)2.71860367
152regulation of lipoprotein metabolic process (GO:0050746)2.71104403
153nuclear pore complex assembly (GO:0051292)2.70647142
154protein K48-linked deubiquitination (GO:0071108)2.70280853
155interleukin-6-mediated signaling pathway (GO:0070102)2.67011739
156positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.66807237
157response to pheromone (GO:0019236)2.66158761
158negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.64337234
159organelle membrane fusion (GO:0090174)2.63872645
160negative regulation of neurotransmitter secretion (GO:0046929)2.63469914
161regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.61569868
162definitive hemopoiesis (GO:0060216)2.60278964
163neurotransmitter catabolic process (GO:0042135)2.58677731
164nerve growth factor signaling pathway (GO:0038180)2.58572163
165fatty acid transmembrane transport (GO:1902001)2.56179511
166regulation of cardiac muscle hypertrophy (GO:0010611)2.53826721
167regulation of establishment or maintenance of cell polarity (GO:0032878)2.51624737
168positive regulation of glycolytic process (GO:0045821)2.50668222
169iron ion import (GO:0097286)2.49642791
170inositol metabolic process (GO:0006020)2.49377447
171regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.48348676
172negative regulation of DNA repair (GO:0045738)2.47449630
173quaternary ammonium group transport (GO:0015697)2.46872674
174regulation of muscle hypertrophy (GO:0014743)2.43218979
175nuclear pore organization (GO:0006999)2.43120717
176histone mRNA catabolic process (GO:0071044)2.43075584
177intracellular lipid transport (GO:0032365)2.41622136
178regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.40975262
179regulation of sulfur metabolic process (GO:0042762)2.40774809
180histone H3-K9 methylation (GO:0051567)2.39249756
181auditory receptor cell differentiation (GO:0042491)2.37516650
182protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.36096851
183positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.35679979
184relaxation of cardiac muscle (GO:0055119)2.34156955
185replicative senescence (GO:0090399)2.34121271
186negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33316074
187carnitine shuttle (GO:0006853)2.32618391
188regulation of sarcomere organization (GO:0060297)2.31996107
189cardiolipin metabolic process (GO:0032048)2.29741835
190histone H3-K4 trimethylation (GO:0080182)2.29565633
191regulation of cofactor metabolic process (GO:0051193)2.29367494
192regulation of coenzyme metabolic process (GO:0051196)2.29367494
193positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28868521
194protein K63-linked deubiquitination (GO:0070536)2.26494808
195negative regulation of digestive system process (GO:0060457)2.25750840
196endosome to melanosome transport (GO:0035646)2.21846734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.66235042
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.95478873
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.74840186
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.03712019
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.97276324
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.45166821
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.19038498
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.68727209
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63895823
10CLOCK_20551151_ChIP-Seq_293T_Human2.60724063
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.57817484
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.48825098
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.43165819
14FUS_26573619_Chip-Seq_HEK293_Human2.41808321
15GBX2_23144817_ChIP-Seq_PC3_Human2.33808295
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.31174137
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.21054381
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.00852473
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95446818
20* TAF15_26573619_Chip-Seq_HEK293_Human1.92294964
21IGF1R_20145208_ChIP-Seq_DFB_Human1.85131339
22EWS_26573619_Chip-Seq_HEK293_Human1.79502606
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78770562
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78714803
25TP53_16413492_ChIP-PET_HCT116_Human1.78086490
26VDR_22108803_ChIP-Seq_LS180_Human1.75914258
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.72162730
28EZH2_27294783_Chip-Seq_NPCs_Mouse1.68340160
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.66752494
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.61496969
31SUZ12_27294783_Chip-Seq_NPCs_Mouse1.61396545
32NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57565001
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57565001
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56883105
35ER_23166858_ChIP-Seq_MCF-7_Human1.56710118
36TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.56636456
37TCF4_23295773_ChIP-Seq_U87_Human1.56060876
38CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.52467957
39TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51976455
40* NANOG_18555785_Chip-Seq_ESCs_Mouse1.51962023
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.48450466
42FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47604221
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46140961
44GATA1_22025678_ChIP-Seq_K562_Human1.45316508
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44859842
46EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.44553124
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.41095833
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.40103717
49ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39771645
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38604334
51E2F1_18555785_Chip-Seq_ESCs_Mouse1.38226913
52CDX2_22108803_ChIP-Seq_LS180_Human1.37391410
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.36803703
54AR_21572438_ChIP-Seq_LNCaP_Human1.34769333
55ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34665246
56BCAT_22108803_ChIP-Seq_LS180_Human1.31825412
57* FOXA2_19822575_ChIP-Seq_HepG2_Human1.31632277
58P53_22387025_ChIP-Seq_ESCs_Mouse1.31238774
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30942453
60ZNF274_21170338_ChIP-Seq_K562_Hela1.30940066
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30181862
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.28933010
63SMAD3_21741376_ChIP-Seq_EPCs_Human1.28130636
64CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25820788
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25319069
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.23344542
67CRX_20693478_ChIP-Seq_RETINA_Mouse1.23333460
68OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20983654
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.19767255
70P300_19829295_ChIP-Seq_ESCs_Human1.19732242
71* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.18883211
72SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.17889541
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.17491313
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.17428329
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.17372629
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.17101478
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.16920445
78* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16436022
79SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15277515
80CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14945292
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14909936
82TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13786342
83* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13708795
84TCF4_18268006_ChIP-ChIP_LS174T_Human1.13378053
85AR_25329375_ChIP-Seq_VCAP_Human1.12768791
86CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12540697
87ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11608592
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11189026
89SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.10959816
90SMAD4_21799915_ChIP-Seq_A2780_Human1.09672140
91SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08868353
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.08823133
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.08716373
94RUNX2_22187159_ChIP-Seq_PCA_Human1.08489488
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08474892
96ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08254939
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08006111
98P300_18555785_Chip-Seq_ESCs_Mouse1.07449214
99TP63_23658742_ChIP-Seq_EP156T_Human1.06818260
100GATA2_21666600_ChIP-Seq_HMVEC_Human1.05829332
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05495262
102OCT4_18555785_Chip-Seq_ESCs_Mouse1.05138082
103BRD4_25478319_ChIP-Seq_HGPS_Human1.04777175
104* TAL1_26923725_Chip-Seq_HPCs_Mouse1.04669105
105SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04559737
106STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.04540419
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04472112
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04472112
109* CBP_20019798_ChIP-Seq_JUKART_Human1.03876886
110* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03876886
111BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03867306
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02336657
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.99977211
114* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99846205
115SOX2_20726797_ChIP-Seq_SW620_Human0.99381281
116HTT_18923047_ChIP-ChIP_STHdh_Human0.98561450
117HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97662159
118FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97113901
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.94900714
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92751481
121TCF4_22108803_ChIP-Seq_LS180_Human0.91862259
122ZFP57_27257070_Chip-Seq_ESCs_Mouse0.91773520
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.89984976
124STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.89192105
125EED_16625203_ChIP-ChIP_MESCs_Mouse0.89115549
126* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87536853
127RNF2_18974828_ChIP-Seq_MESCs_Mouse0.87492400
128EZH2_18974828_ChIP-Seq_MESCs_Mouse0.87492400
129* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86652149
130* HNF4A_19822575_ChIP-Seq_HepG2_Human0.83612964
131TRIM28_21343339_ChIP-Seq_HEK293_Human0.83284160
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83203376
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.82943246
134* STAT3_23295773_ChIP-Seq_U87_Human0.82837331
135* SOX2_19829295_ChIP-Seq_ESCs_Human0.81813552
136* NANOG_19829295_ChIP-Seq_ESCs_Human0.81813552
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81074710
138FOXA1_25552417_ChIP-Seq_VCAP_Human0.79326144
139FLI1_21867929_ChIP-Seq_TH2_Mouse0.77962022
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77952873
141TP53_18474530_ChIP-ChIP_U2OS_Human0.76759602
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76271333
143EOMES_21245162_ChIP-Seq_HESCs_Human0.76108640
144SOX2_27498859_Chip-Seq_STOMACH_Mouse0.75925863
145* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.75845076
146TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75772629
147CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75214638
148RXR_22108803_ChIP-Seq_LS180_Human0.75040558
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.74486425
150ARNT_22903824_ChIP-Seq_MCF-7_Human0.74350924
151CJUN_26792858_Chip-Seq_BT549_Human0.74329934
152AHR_22903824_ChIP-Seq_MCF-7_Human0.74148059
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.73846674
154TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.72951967
155WT1_19549856_ChIP-ChIP_CCG9911_Human0.72171221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation8.00808367
2MP0002139_abnormal_hepatobiliary_system5.98338303
3MP0005365_abnormal_bile_salt5.10616079
4MP0005360_urolithiasis5.03328962
5MP0005085_abnormal_gallbladder_physiolo4.65680374
6MP0008057_abnormal_DNA_replication4.19639076
7MP0008875_abnormal_xenobiotic_pharmacok3.75891715
8MP0003806_abnormal_nucleotide_metabolis3.46890106
9MP0003656_abnormal_erythrocyte_physiolo3.34666499
10MP0010329_abnormal_lipoprotein_level3.06269896
11MP0003195_calcinosis2.93723720
12MP0003252_abnormal_bile_duct2.68496915
13MP0005670_abnormal_white_adipose2.54046274
14MP0005174_abnormal_tail_pigmentation2.50657112
15MP0005464_abnormal_platelet_physiology2.46809581
16MP0005083_abnormal_biliary_tract2.39200725
17MP0005187_abnormal_penis_morphology2.38152094
18MP0000383_abnormal_hair_follicle2.36207503
19MP0006054_spinal_hemorrhage2.35031532
20MP0003787_abnormal_imprinting2.27385295
21MP0005332_abnormal_amino_acid2.23272162
22MP0000015_abnormal_ear_pigmentation2.17872349
23MP0003191_abnormal_cellular_cholesterol2.15091205
24MP0002837_dystrophic_cardiac_calcinosis2.09350013
25MP0002118_abnormal_lipid_homeostasis2.08760437
26MP0005075_abnormal_melanosome_morpholog1.99360423
27MP0004484_altered_response_of1.97085387
28MP0002009_preneoplasia1.96207091
29MP0001666_abnormal_nutrient_absorption1.95835394
30MP0004130_abnormal_muscle_cell1.91081081
31MP0009840_abnormal_foam_cell1.88191963
32MP0010678_abnormal_skin_adnexa1.87355655
33MP0002876_abnormal_thyroid_physiology1.86521028
34MP0003950_abnormal_plasma_membrane1.81793091
35MP0004043_abnormal_pH_regulation1.73318392
36MP0000013_abnormal_adipose_tissue1.71351701
37MP0000609_abnormal_liver_physiology1.70596915
38MP0002909_abnormal_adrenal_gland1.64617026
39MP0003868_abnormal_feces_composition1.64226764
40MP0002877_abnormal_melanocyte_morpholog1.62135074
41MP0000371_diluted_coat_color1.60939862
42MP0003183_abnormal_peptide_metabolism1.60659839
43MP0003890_abnormal_embryonic-extraembry1.59853389
44MP0000372_irregular_coat_pigmentation1.59117885
45MP0005584_abnormal_enzyme/coenzyme_acti1.58098088
46MP0005084_abnormal_gallbladder_morpholo1.57825300
47MP0002078_abnormal_glucose_homeostasis1.54234425
48MP0002138_abnormal_hepatobiliary_system1.53656826
49MP0009780_abnormal_chondrocyte_physiolo1.51937755
50MP0004084_abnormal_cardiac_muscle1.45061028
51MP0005646_abnormal_pituitary_gland1.42966856
52MP0002102_abnormal_ear_morphology1.38815585
53MP0004019_abnormal_vitamin_homeostasis1.36600559
54MP0009643_abnormal_urine_homeostasis1.34068487
55MP0005535_abnormal_body_temperature1.31518678
56MP0005319_abnormal_enzyme/_coenzyme1.31187661
57MP0001764_abnormal_homeostasis1.29464694
58MP0006276_abnormal_autonomic_nervous1.27863068
59MP0002971_abnormal_brown_adipose1.26441915
60MP0008877_abnormal_DNA_methylation1.25293165
61MP0005666_abnormal_adipose_tissue1.24205386
62MP0010386_abnormal_urinary_bladder1.21121873
63MP0000647_abnormal_sebaceous_gland1.19542503
64MP0003943_abnormal_hepatobiliary_system1.15494270
65MP0000003_abnormal_adipose_tissue1.15277903
66MP0008775_abnormal_heart_ventricle1.14342275
67MP0005266_abnormal_metabolism1.14332186
68MP0002095_abnormal_skin_pigmentation1.13854103
69MP0005334_abnormal_fat_pad1.12276084
70MP0005645_abnormal_hypothalamus_physiol1.12190206
71MP0004145_abnormal_muscle_electrophysio1.10734589
72MP0005220_abnormal_exocrine_pancreas1.09221786
73MP0006036_abnormal_mitochondrial_physio1.07865694
74MP0001984_abnormal_olfaction1.05897870
75MP0005375_adipose_tissue_phenotype1.05203727
76MP0004147_increased_porphyrin_level1.03175270
77MP0003121_genomic_imprinting1.02639319
78MP0003329_amyloid_beta_deposits1.00680267
79MP0002928_abnormal_bile_duct1.00550907
80MP0001944_abnormal_pancreas_morphology1.00096233
81MP0003828_pulmonary_edema0.99500413
82MP0005448_abnormal_energy_balance0.99123755
83MP0001501_abnormal_sleep_pattern0.98928868
84MP0001529_abnormal_vocalization0.97878467
85MP0004233_abnormal_muscle_weight0.96824040
86MP0010352_gastrointestinal_tract_polyps0.96164583
87MP0001756_abnormal_urination0.94789546
88MP0000230_abnormal_systemic_arterial0.94350758
89MP0002822_catalepsy0.94311171
90MP0009384_cardiac_valve_regurgitation0.93999845
91MP0004134_abnormal_chest_morphology0.93469959
92MP0005636_abnormal_mineral_homeostasis0.93374912
93MP0000604_amyloidosis0.92931273
94MP0001661_extended_life_span0.92740517
95MP0003690_abnormal_glial_cell0.92492251
96MP0003953_abnormal_hormone_level0.91455536
97MP0002168_other_aberrant_phenotype0.91232779
98MP0001879_abnormal_lymphatic_vessel0.90350947
99MP0003045_fibrosis0.90086322
100MP0004215_abnormal_myocardial_fiber0.89903687
101MP0000465_gastrointestinal_hemorrhage0.89589766
102MP0005253_abnormal_eye_physiology0.88406918
103MP0004808_abnormal_hematopoietic_stem0.87276580
104MP0005058_abnormal_lysosome_morphology0.87159822
105MP0004270_analgesia0.85780289
106MP0005379_endocrine/exocrine_gland_phen0.81725695
107MP0004883_abnormal_blood_vessel0.80928266
108MP0000639_abnormal_adrenal_gland0.80762547
109MP0003724_increased_susceptibility_to0.80357362
110MP0005503_abnormal_tendon_morphology0.80131171
111MP0008007_abnormal_cellular_replicative0.79876992
112MP0005386_behavior/neurological_phenoty0.79060440
113MP0004924_abnormal_behavior0.79060440
114MP0003122_maternal_imprinting0.79027741
115MP0000598_abnormal_liver_morphology0.78849493
116MP0002254_reproductive_system_inflammat0.77368306
117MP0004264_abnormal_extraembryonic_tissu0.77147885
118MP0003221_abnormal_cardiomyocyte_apopto0.75610422
119MP0009642_abnormal_blood_homeostasis0.75264847
120MP0002736_abnormal_nociception_after0.74879500
121MP0001765_abnormal_ion_homeostasis0.74172151
122MP0003186_abnormal_redox_activity0.73132845
123MP0002970_abnormal_white_adipose0.73113274
124MP0002693_abnormal_pancreas_physiology0.72711420
125MP0003763_abnormal_thymus_physiology0.72599376
126MP0009115_abnormal_fat_cell0.72379126
127MP0005551_abnormal_eye_electrophysiolog0.72310277
128MP0003300_gastrointestinal_ulcer0.71899085
129MP0004185_abnormal_adipocyte_glucose0.70942632
130MP0001502_abnormal_circadian_rhythm0.70866831
131MP0002332_abnormal_exercise_endurance0.70378617
132MP0001324_abnormal_eye_pigmentation0.70132504
133MP0005620_abnormal_muscle_contractility0.68539543
134MP0001177_atelectasis0.68376054
135MP0008874_decreased_physiological_sensi0.68067169
136MP0003959_abnormal_lean_body0.67892202
137MP0004381_abnormal_hair_follicle0.67830614
138MP0002069_abnormal_eating/drinking_beha0.67423840
139MP0000427_abnormal_hair_cycle0.66977594
140MP0009697_abnormal_copulation0.66644303
141MP0002638_abnormal_pupillary_reflex0.65663800
142MP0003011_delayed_dark_adaptation0.65560053
143MP0002128_abnormal_blood_circulation0.64096546
144MP0010368_abnormal_lymphatic_system0.63919467
145MP0002090_abnormal_vision0.63586906
146MP0002166_altered_tumor_susceptibility0.63428760
147MP0002177_abnormal_outer_ear0.63055922
148MP0002108_abnormal_muscle_morphology0.63055217
149MP0001968_abnormal_touch/_nociception0.62942457
150MP0008004_abnormal_stomach_pH0.62677645
151MP0009765_abnormal_xenobiotic_induced0.62566447
152MP0005408_hypopigmentation0.62414421
153MP0005452_abnormal_adipose_tissue0.62413114
154MP0001915_intracranial_hemorrhage0.62284275
155MP0009046_muscle_twitch0.61434054
156MP0003937_abnormal_limbs/digits/tail_de0.61419464
157MP0008770_decreased_survivor_rate0.60012228
158MP0002067_abnormal_sensory_capabilities0.60009753
159MP0005376_homeostasis/metabolism_phenot0.58527102
160MP0001784_abnormal_fluid_regulation0.58281222
161MP0004036_abnormal_muscle_relaxation0.57882046
162MP0005164_abnormal_response_to0.57812281
163MP0006035_abnormal_mitochondrial_morpho0.57644665
164MP0005395_other_phenotype0.57495507
165MP0002272_abnormal_nervous_system0.57488853
166MP0003646_muscle_fatigue0.56529325
167MP0003633_abnormal_nervous_system0.55193728
168MP0000538_abnormal_urinary_bladder0.54628087

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.68669444
2Intrahepatic cholestasis (HP:0001406)4.66916645
3Xanthomatosis (HP:0000991)4.47982687
4Ketosis (HP:0001946)4.47318749
5Papillary thyroid carcinoma (HP:0002895)4.42983802
6Increased mean platelet volume (HP:0011877)4.41675611
7Hyperlipoproteinemia (HP:0010980)4.28336428
8Ketoacidosis (HP:0001993)4.22965573
9Deep venous thrombosis (HP:0002625)4.22206855
10Hypoglycemic coma (HP:0001325)4.12677898
11Abnormal platelet volume (HP:0011876)3.92737937
12Hypoalphalipoproteinemia (HP:0003233)3.81339292
13Hyperammonemia (HP:0001987)3.75299757
14Complement deficiency (HP:0004431)3.65189092
15Poikilocytosis (HP:0004447)3.64141128
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.63638668
17Prolonged partial thromboplastin time (HP:0003645)3.57357417
18Hypobetalipoproteinemia (HP:0003563)3.54788236
19Hyperglycinemia (HP:0002154)3.53840615
20Abnormality of serine family amino acid metabolism (HP:0010894)3.51976763
21Abnormality of glycine metabolism (HP:0010895)3.51976763
22Hypolipoproteinemia (HP:0010981)3.51852465
23Hypoglycemic seizures (HP:0002173)3.49322896
24Generalized hypopigmentation of hair (HP:0011358)3.46001728
25Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.41250842
26Hyperglycinuria (HP:0003108)3.36323757
27Gingival bleeding (HP:0000225)3.32413539
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.27165334
29Epidermoid cyst (HP:0200040)3.26145006
30Conjugated hyperbilirubinemia (HP:0002908)3.25851971
31Oligomenorrhea (HP:0000876)3.24742446
32Abnormality of fatty-acid metabolism (HP:0004359)3.22348907
33Absent speech (HP:0001344)3.21592014
34Gaze-evoked nystagmus (HP:0000640)3.20307156
35Protruding tongue (HP:0010808)3.14324234
36Prolonged bleeding time (HP:0003010)3.09879399
37Hyperinsulinemic hypoglycemia (HP:0000825)3.04652229
38Thyroid carcinoma (HP:0002890)3.03349852
39Gout (HP:0001997)2.98280875
40Chronic hepatic failure (HP:0100626)2.96265850
41Abnormality of the intrinsic pathway (HP:0010989)2.95003829
42Hyperglycemia (HP:0003074)2.90336223
43Short chin (HP:0000331)2.88346777
44Drooling (HP:0002307)2.84595451
45Renal cortical cysts (HP:0000803)2.83784431
46Abnormality of the renal cortex (HP:0011035)2.83636932
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.83033063
48Delayed CNS myelination (HP:0002188)2.82509266
49Abnormality of glutamine family amino acid metabolism (HP:0010902)2.82305279
50Myoglobinuria (HP:0002913)2.79911417
51Abnormality of the common coagulation pathway (HP:0010990)2.79818713
52Symptomatic seizures (HP:0011145)2.70798395
53Widely spaced teeth (HP:0000687)2.69783159
54Menorrhagia (HP:0000132)2.68102154
55Generalized aminoaciduria (HP:0002909)2.66831690
56Tubulointerstitial nephritis (HP:0001970)2.63372183
57Acanthocytosis (HP:0001927)2.63233423
58Abnormality of purine metabolism (HP:0004352)2.61455405
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.60892758
60Excessive salivation (HP:0003781)2.59699617
61Metabolic acidosis (HP:0001942)2.59496228
62Blue irides (HP:0000635)2.55055533
63Late onset (HP:0003584)2.52392191
64Volvulus (HP:0002580)2.52259275
65Abnormality of complement system (HP:0005339)2.51337288
66* Abnormality of serum amino acid levels (HP:0003112)2.51236605
67Abnormality of methionine metabolism (HP:0010901)2.51064633
68Medial flaring of the eyebrow (HP:0010747)2.50960013
69Truncal obesity (HP:0001956)2.50746200
70Central scotoma (HP:0000603)2.49216015
71Dicarboxylic aciduria (HP:0003215)2.49168305
72Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49168305
73Cerebral edema (HP:0002181)2.48417330
74Disproportionate short-trunk short stature (HP:0003521)2.47565630
75Febrile seizures (HP:0002373)2.47282385
76Fat malabsorption (HP:0002630)2.43964751
77Broad-based gait (HP:0002136)2.43935762
78Hyperkalemia (HP:0002153)2.43872463
79Exercise-induced myalgia (HP:0003738)2.43784654
80Neoplasm of the small intestine (HP:0100833)2.43285011
81Biliary tract neoplasm (HP:0100574)2.42422353
82Skin nodule (HP:0200036)2.42029282
83Lethargy (HP:0001254)2.34122929
84Hyperbilirubinemia (HP:0002904)2.34012160
85Insulin-resistant diabetes mellitus (HP:0000831)2.33276242
86Increased muscle lipid content (HP:0009058)2.32932730
87Acute myeloid leukemia (HP:0004808)2.27080502
88Hyperventilation (HP:0002883)2.20569773
89Glycosuria (HP:0003076)2.19991099
90Abnormality of urine glucose concentration (HP:0011016)2.19991099
91Pancreatic cysts (HP:0001737)2.19900099
92Abnormality of the wing of the ilium (HP:0011867)2.15449422
93Thyroiditis (HP:0100646)2.14493944
94Sensorimotor neuropathy (HP:0007141)2.12812770
95Amyloidosis (HP:0011034)2.12736502
96Enlarged kidneys (HP:0000105)2.12178074
97Hepatocellular carcinoma (HP:0001402)2.11813691
98Long clavicles (HP:0000890)2.10691082
99Abnormality of nucleobase metabolism (HP:0010932)2.08819038
100Brushfield spots (HP:0001088)2.08796263
101Abnormality of the renal medulla (HP:0100957)2.07014808
102Irritability (HP:0000737)2.06792208
103Hypoplastic iliac wings (HP:0002866)2.06019957
104Abnormal biliary tract morphology (HP:0012440)2.05143990
105Metaphyseal dysplasia (HP:0100255)2.04433199
106Epistaxis (HP:0000421)2.04196836
107Mitral stenosis (HP:0001718)2.03874083
108Scotoma (HP:0000575)2.02637861
109Aplasia/Hypoplasia of the tibia (HP:0005772)2.01883554
110Vomiting (HP:0002013)2.00456357
111Acute encephalopathy (HP:0006846)2.00377177
112Tubulointerstitial abnormality (HP:0001969)1.99664129
113Prominent nose (HP:0000448)1.98316455
114Increased purine levels (HP:0004368)1.97789693
115Hyperuricemia (HP:0002149)1.97789693
116Fair hair (HP:0002286)1.96135492
117Subaortic stenosis (HP:0001682)1.96062739
118Abnormality of the left ventricular outflow tract (HP:0011103)1.96062739
119Gonadotropin excess (HP:0000837)1.95502418
120Hepatic necrosis (HP:0002605)1.95285081
121Hypothermia (HP:0002045)1.94935395
122Abnormal gallbladder morphology (HP:0012437)1.94905154
123Pancreatic fibrosis (HP:0100732)1.94317446
124Torticollis (HP:0000473)1.93931911
125Joint hemorrhage (HP:0005261)1.93662706
126Exotropia (HP:0000577)1.93193892
127Vascular calcification (HP:0004934)1.90925459
128Pheochromocytoma (HP:0002666)1.90525052
129Abnormality of midbrain morphology (HP:0002418)1.90196615
130Molar tooth sign on MRI (HP:0002419)1.90196615
131Intestinal atresia (HP:0011100)1.89135604
132Cerebral palsy (HP:0100021)1.89001148
133Protuberant abdomen (HP:0001538)1.88672686
134Abnormality of the ischium (HP:0003174)1.88574456
135Cerebellar dysplasia (HP:0007033)1.88532127
136Portal hypertension (HP:0001409)1.87934453
137Craniofacial dystonia (HP:0012179)1.87531836
138Abnormality of the pubic bones (HP:0003172)1.87180367
139Thyroid-stimulating hormone excess (HP:0002925)1.87151197
140Growth hormone excess (HP:0000845)1.85955680
141Cone-rod dystrophy (HP:0000548)1.85850687
142Curly hair (HP:0002212)1.85798324
143Tachypnea (HP:0002789)1.85088263
144Barrel-shaped chest (HP:0001552)1.84657916
145Type II lissencephaly (HP:0007260)1.84053860
146Systemic lupus erythematosus (HP:0002725)1.83775056
147Albinism (HP:0001022)1.82706422
148Lipid accumulation in hepatocytes (HP:0006561)1.81912542
149Hypercholesterolemia (HP:0003124)1.81730325
150Methylmalonic aciduria (HP:0012120)1.81238941
151Insulin resistance (HP:0000855)1.80384349
152Clumsiness (HP:0002312)1.78925814
153Poor coordination (HP:0002370)1.78491581
154Vacuolated lymphocytes (HP:0001922)1.78417282
155Pancreatitis (HP:0001733)1.77826601
156Increased intramyocellular lipid droplets (HP:0012240)1.77798842
157Nephronophthisis (HP:0000090)1.77458650
158Spontaneous abortion (HP:0005268)1.75948466
159Macroorchidism (HP:0000053)1.74549241
160Pancreatic islet-cell hyperplasia (HP:0004510)1.73502356
161Calf muscle hypertrophy (HP:0008981)1.73464910
162Cardiovascular calcification (HP:0011915)1.73196184
163Limb hypertonia (HP:0002509)1.73002692
164Neuroendocrine neoplasm (HP:0100634)1.72375404
165EEG with generalized epileptiform discharges (HP:0011198)1.72348004
166Neoplasm of the rectum (HP:0100743)1.72209439
167Proximal tubulopathy (HP:0000114)1.72122005
168Opisthotonus (HP:0002179)1.71260286
169Hyperphosphaturia (HP:0003109)1.70758829
170Myocardial infarction (HP:0001658)1.70134370
171Hip dysplasia (HP:0001385)1.70051700
172Epileptiform EEG discharges (HP:0011182)1.69877882
173Hypoplastic labia majora (HP:0000059)1.68438169
174Thickened calvaria (HP:0002684)1.67822377
175Inability to walk (HP:0002540)1.65082329
176Genital tract atresia (HP:0001827)1.64146777
177Congenital primary aphakia (HP:0007707)1.61238909
178Chorioretinal atrophy (HP:0000533)1.60999090
179Cupped ear (HP:0000378)1.60871151
180Large for gestational age (HP:0001520)1.60811182
181True hermaphroditism (HP:0010459)1.59929981
182Abnormality of endocrine pancreas physiology (HP:0012093)1.59056493
183Abnormality of the pancreatic islet cells (HP:0006476)1.59056493
184Genetic anticipation (HP:0003743)1.57826784
185Conjunctival telangiectasia (HP:0000524)1.57733118
186Neoplasm of the thyroid gland (HP:0100031)1.57323717
187Abnormality of potassium homeostasis (HP:0011042)1.55824635
188Abnormality of the nasal septum (HP:0000419)1.55435566
189Abnormality of the parathyroid morphology (HP:0011766)1.55351575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.28362123
2ACVR1B3.86333599
3INSRR3.86131213
4ERN13.20313927
5FRK3.11312267
6AKT32.65636913
7MAP2K42.56341620
8SIK12.51894936
9MAPK152.33617706
10LATS12.30266317
11STK38L2.26015802
12MAP3K122.20051716
13FLT32.16221933
14OBSCN2.06440230
15MAP3K132.03304161
16FGFR42.01553411
17TEC1.89238462
18MAP3K61.89021553
19MAP2K71.88395199
20NUAK11.76721103
21CAMK1D1.76269164
22CASK1.69935993
23ERBB31.64890212
24PKN21.62269791
25STK391.62159353
26PRKD31.61540333
27MAP3K41.59407182
28MAP4K21.58785494
29PHKG11.55378198
30PHKG21.55378198
31NEK91.54774792
32STK31.50103494
33TRPM71.47899817
34TAOK31.43073172
35PDK21.39011067
36TGFBR21.36091291
37EPHA41.33131961
38PIK3CG1.31907092
39CAMK1G1.29356207
40PINK11.28751545
41RET1.26998503
42TRIB31.25317799
43FER1.20270801
44TGFBR11.15788860
45MYLK1.14974569
46YES11.14137875
47TNIK1.13160823
48BRSK21.09497983
49NTRK31.08259539
50FGFR21.07196255
51MAP3K21.05188067
52WNK31.00506700
53BCR0.99906270
54ARAF0.93926129
55WNK10.93742032
56KSR10.93554844
57SGK20.93453337
58SGK4940.90941935
59SGK2230.90941935
60TAF10.90568150
61PRKCH0.89986468
62BTK0.89208678
63DAPK20.88618407
64TRIM280.86637399
65ADRBK20.85946316
66CSNK1G20.84951823
67CAMKK20.83935570
68SIK30.82017734
69JAK10.81867791
70PAK30.79676635
71EIF2AK30.79312724
72GRK50.77549141
73BMPR20.76078179
74SYK0.75334793
75MAP3K140.75225282
76GRK10.74997635
77PIK3CA0.74257814
78MAP2K10.73468514
79BRD40.73434093
80ITK0.73105207
81NTRK10.73076885
82STK240.72867142
83MINK10.72579921
84CAMK2G0.72540006
85MAP3K70.72151303
86CSNK1G30.71696991
87MUSK0.70472849
88FGFR30.69736800
89ADRBK10.69657943
90TYK20.67619180
91PRKAA20.67051523
92PBK0.66812347
93MAPKAPK50.66471108
94PTK2B0.65245957
95RAF10.64706029
96CSNK1G10.61626851
97PDK40.60271075
98PDK30.60271075
99MAPK110.60128836
100SGK10.60090875
101IRAK10.59372645
102EIF2AK10.58985265
103CSNK1A1L0.58626796
104HCK0.57603713
105ZAK0.56885432
106MELK0.55868435
107GRK70.54276737
108PRKAA10.53439276
109MST40.53402755
110MKNK20.52128282
111PDGFRB0.52077637
112JAK20.51561372
113MAP2K30.51094372
114IGF1R0.50150478
115MAPKAPK30.49501302
116CSF1R0.49300199
117KIT0.48565584
118LMTK20.48360143
119PDGFRA0.47870995
120FGFR10.47854225
121WNK40.46495842
122CSNK1D0.46251465
123OXSR10.46063169
124NEK60.45593689
125CDK60.45503548
126PRKCE0.44997026
127MAPK130.44804957
128IRAK30.43994392
129PDPK10.43877495
130PLK20.43714826
131SCYL20.42784338
132SGK30.42349962
133PDK10.40413552
134MAPK70.40210335
135PRKCZ0.40206325
136CAMK2A0.39847901
137PRKACG0.39517429
138PIM10.39325913
139MAPK120.37795465
140PRKCQ0.37521287
141ERBB20.37499211
142RPS6KA20.36966614
143DMPK0.35635849
144PRPF4B0.35481184
145MAP3K50.34407853
146BMPR1B0.34191002
147RPS6KB10.33748313
148MST1R0.32445800
149NLK0.32090888
150CDK50.31832578

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.30949073
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.72283811
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.70711073
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.65931021
5Propanoate metabolism_Homo sapiens_hsa006402.60151152
6Fatty acid degradation_Homo sapiens_hsa000712.55243105
7Nitrogen metabolism_Homo sapiens_hsa009102.38039529
8Tryptophan metabolism_Homo sapiens_hsa003802.26803963
9Fatty acid metabolism_Homo sapiens_hsa012122.26191373
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.21549458
11Dorso-ventral axis formation_Homo sapiens_hsa043202.16509269
12Arginine biosynthesis_Homo sapiens_hsa002202.15606945
13Platelet activation_Homo sapiens_hsa046112.15037357
14Butanoate metabolism_Homo sapiens_hsa006502.14164278
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14031303
16Sulfur metabolism_Homo sapiens_hsa009202.11236729
17PPAR signaling pathway_Homo sapiens_hsa033202.00295194
18Peroxisome_Homo sapiens_hsa041461.97314074
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.96350954
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89213272
21Pyruvate metabolism_Homo sapiens_hsa006201.88896189
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.87666264
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87636072
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.82989571
25Fatty acid elongation_Homo sapiens_hsa000621.68586253
26Complement and coagulation cascades_Homo sapiens_hsa046101.63121798
27beta-Alanine metabolism_Homo sapiens_hsa004101.62064860
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.61505401
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56453530
30Phenylalanine metabolism_Homo sapiens_hsa003601.54697181
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.52790982
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51859488
33Chemical carcinogenesis_Homo sapiens_hsa052041.51214592
34Histidine metabolism_Homo sapiens_hsa003401.50897811
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.48650840
36Ether lipid metabolism_Homo sapiens_hsa005651.48278893
37Linoleic acid metabolism_Homo sapiens_hsa005911.43244546
38Starch and sucrose metabolism_Homo sapiens_hsa005001.42998999
39FoxO signaling pathway_Homo sapiens_hsa040681.42156020
40Tyrosine metabolism_Homo sapiens_hsa003501.40915099
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.39290455
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36865678
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29200098
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26754776
45Inositol phosphate metabolism_Homo sapiens_hsa005621.26509599
46Protein export_Homo sapiens_hsa030601.26326856
47Drug metabolism - other enzymes_Homo sapiens_hsa009831.21497276
48Vascular smooth muscle contraction_Homo sapiens_hsa042701.18217078
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15618064
50Caffeine metabolism_Homo sapiens_hsa002321.15547701
51Carbon metabolism_Homo sapiens_hsa012001.14400997
52Glycerolipid metabolism_Homo sapiens_hsa005611.14041329
53Bile secretion_Homo sapiens_hsa049761.13100388
54Fatty acid biosynthesis_Homo sapiens_hsa000611.11010938
55Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08071222
56Retinol metabolism_Homo sapiens_hsa008301.07168242
57Sphingolipid metabolism_Homo sapiens_hsa006001.06293821
58Regulation of autophagy_Homo sapiens_hsa041401.03931703
59Folate biosynthesis_Homo sapiens_hsa007900.99778016
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.99205531
61Serotonergic synapse_Homo sapiens_hsa047260.98102732
62ECM-receptor interaction_Homo sapiens_hsa045120.96891599
63Choline metabolism in cancer_Homo sapiens_hsa052310.93381830
64Long-term depression_Homo sapiens_hsa047300.87775782
65ABC transporters_Homo sapiens_hsa020100.87676770
66Basal transcription factors_Homo sapiens_hsa030220.87561281
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86792254
68Pancreatic secretion_Homo sapiens_hsa049720.85939840
69Biosynthesis of amino acids_Homo sapiens_hsa012300.85202812
70Staphylococcus aureus infection_Homo sapiens_hsa051500.83915717
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.82803261
72Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82623959
73Arginine and proline metabolism_Homo sapiens_hsa003300.82324989
74Fat digestion and absorption_Homo sapiens_hsa049750.82212864
75Non-small cell lung cancer_Homo sapiens_hsa052230.81848219
76Adherens junction_Homo sapiens_hsa045200.79884817
77Ovarian steroidogenesis_Homo sapiens_hsa049130.78227196
78Non-homologous end-joining_Homo sapiens_hsa034500.77716064
79Selenocompound metabolism_Homo sapiens_hsa004500.77457127
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77000482
81Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75921051
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74097629
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73717907
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.73308049
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72377027
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.72084204
87Endometrial cancer_Homo sapiens_hsa052130.71782816
88Renal cell carcinoma_Homo sapiens_hsa052110.71593041
89Glucagon signaling pathway_Homo sapiens_hsa049220.71562029
90Vitamin B6 metabolism_Homo sapiens_hsa007500.71349591
91Insulin resistance_Homo sapiens_hsa049310.67346218
92Insulin secretion_Homo sapiens_hsa049110.67135114
93T cell receptor signaling pathway_Homo sapiens_hsa046600.66887823
94Prostate cancer_Homo sapiens_hsa052150.66720440
95Arachidonic acid metabolism_Homo sapiens_hsa005900.66201008
96TGF-beta signaling pathway_Homo sapiens_hsa043500.66022019
97Vibrio cholerae infection_Homo sapiens_hsa051100.65750861
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61960367
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61606890
100Systemic lupus erythematosus_Homo sapiens_hsa053220.61228873
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.60957954
102Vitamin digestion and absorption_Homo sapiens_hsa049770.60355338
103Renin-angiotensin system_Homo sapiens_hsa046140.59956646
104Cysteine and methionine metabolism_Homo sapiens_hsa002700.59625704
105Collecting duct acid secretion_Homo sapiens_hsa049660.58681659
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57918403
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57875959
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56753893
109Focal adhesion_Homo sapiens_hsa045100.56136061
110Prolactin signaling pathway_Homo sapiens_hsa049170.55942267
111Phototransduction_Homo sapiens_hsa047440.55394622
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55377419
113Glioma_Homo sapiens_hsa052140.54798359
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54405551
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.54181793
116Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.53922567
117Alcoholism_Homo sapiens_hsa050340.53789769
118Oxytocin signaling pathway_Homo sapiens_hsa049210.52250014
119Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50073694
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49827669
121Steroid biosynthesis_Homo sapiens_hsa001000.49744899
122Hematopoietic cell lineage_Homo sapiens_hsa046400.48914618
123mTOR signaling pathway_Homo sapiens_hsa041500.47973501
124Metabolic pathways_Homo sapiens_hsa011000.47582508
125Pancreatic cancer_Homo sapiens_hsa052120.45519400
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44306644
127p53 signaling pathway_Homo sapiens_hsa041150.43600385
128Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43494517
129Glutathione metabolism_Homo sapiens_hsa004800.42063668
130Synaptic vesicle cycle_Homo sapiens_hsa047210.40158385
131Thyroid hormone synthesis_Homo sapiens_hsa049180.39702697
132Cocaine addiction_Homo sapiens_hsa050300.39055438
133Prion diseases_Homo sapiens_hsa050200.37338198
134Lysosome_Homo sapiens_hsa041420.36784715
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35965626
136Insulin signaling pathway_Homo sapiens_hsa049100.35728679
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.33364083
138Amphetamine addiction_Homo sapiens_hsa050310.29777549
139Renin secretion_Homo sapiens_hsa049240.29232506
140Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29231357
141Circadian rhythm_Homo sapiens_hsa047100.28848204
142Type II diabetes mellitus_Homo sapiens_hsa049300.28728172
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27898836
144GABAergic synapse_Homo sapiens_hsa047270.27335923
145AMPK signaling pathway_Homo sapiens_hsa041520.26880679
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.26866764
147Oxidative phosphorylation_Homo sapiens_hsa001900.26572090
148Lysine degradation_Homo sapiens_hsa003100.24411719
149Olfactory transduction_Homo sapiens_hsa047400.22600952
150Dopaminergic synapse_Homo sapiens_hsa047280.22443904
151Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.20816671
152alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19763045
153Galactose metabolism_Homo sapiens_hsa000520.18859355
154Taste transduction_Homo sapiens_hsa047420.18287682
155Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.18011438
156N-Glycan biosynthesis_Homo sapiens_hsa005100.17804035

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