FBXL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.05891299
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.96375464
3negative regulation of cell killing (GO:0031342)5.96375464
4positive regulation by organism of defense response of other organism involved in symbiotic interact5.86162153
5modulation by symbiont of host immune response (GO:0052553)5.86162153
6positive regulation by symbiont of host defense response (GO:0052509)5.86162153
7modulation by symbiont of host defense response (GO:0052031)5.86162153
8modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.86162153
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.86162153
10detection of molecule of bacterial origin (GO:0032490)5.83543793
11positive regulation of gamma-delta T cell activation (GO:0046645)5.61627725
12axon ensheathment in central nervous system (GO:0032291)5.35952920
13central nervous system myelination (GO:0022010)5.35952920
14positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.29346266
15regulation of B cell receptor signaling pathway (GO:0050855)5.24375488
16detection of other organism (GO:0098543)5.21683323
17microglial cell activation (GO:0001774)4.99824118
18detection of external biotic stimulus (GO:0098581)4.97784018
19neutrophil activation involved in immune response (GO:0002283)4.92544418
20macrophage activation involved in immune response (GO:0002281)4.84865325
21cellular extravasation (GO:0045123)4.76225470
22negative regulation of neurotransmitter secretion (GO:0046929)4.61261127
23detection of bacterium (GO:0016045)4.55414822
24response to peptidoglycan (GO:0032494)4.49352608
25neutrophil mediated immunity (GO:0002446)4.41307652
26detection of biotic stimulus (GO:0009595)4.36188201
27regulation of interferon-beta biosynthetic process (GO:0045357)4.35120087
28antigen processing and presentation of endogenous antigen (GO:0019883)4.33106270
29eye photoreceptor cell differentiation (GO:0001754)4.28658612
30photoreceptor cell differentiation (GO:0046530)4.28658612
31response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.23841001
32response to host immune response (GO:0052572)4.23841001
33macrophage activation (GO:0042116)4.23779516
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.20969168
35negative regulation of lymphocyte mediated immunity (GO:0002707)4.16778395
36rhodopsin mediated signaling pathway (GO:0016056)4.09221167
37positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.08181429
38regulation of rhodopsin mediated signaling pathway (GO:0022400)4.01215733
39regulation of gamma-delta T cell activation (GO:0046643)4.01070788
40negative regulation of interleukin-12 production (GO:0032695)3.98731209
41neutrophil activation (GO:0042119)3.97863978
42axon ensheathment (GO:0008366)3.90911855
43ensheathment of neurons (GO:0007272)3.90911855
44myeloid leukocyte mediated immunity (GO:0002444)3.87354843
45positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.86573918
46myelination (GO:0042552)3.86415626
47regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.86000395
48myelin maintenance (GO:0043217)3.85684313
49apical protein localization (GO:0045176)3.84229371
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83136102
51response to host (GO:0075136)3.83136102
52response to host defenses (GO:0052200)3.83136102
53negative regulation of neurotransmitter transport (GO:0051589)3.78451574
54asymmetric protein localization (GO:0008105)3.75926037
55respiratory burst (GO:0045730)3.75497366
56leukocyte aggregation (GO:0070486)3.72687329
57regulation of synaptic vesicle exocytosis (GO:2000300)3.71042526
58retinal rod cell development (GO:0046548)3.66337241
59regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.66001252
60myeloid cell activation involved in immune response (GO:0002275)3.63373676
61response to interleukin-15 (GO:0070672)3.63098338
62antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.62544333
63regulation of gamma-delta T cell differentiation (GO:0045586)3.60044506
64production of molecular mediator involved in inflammatory response (GO:0002532)3.59324433
65detection of light stimulus involved in visual perception (GO:0050908)3.56103652
66detection of light stimulus involved in sensory perception (GO:0050962)3.56103652
67positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.55928401
68presynaptic membrane assembly (GO:0097105)3.55038395
69negative regulation of leukocyte mediated immunity (GO:0002704)3.50249314
70granulocyte activation (GO:0036230)3.50135926
71cellular potassium ion homeostasis (GO:0030007)3.49860761
72negative regulation of T cell mediated immunity (GO:0002710)3.46547422
73positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.45141773
74cellular response to interleukin-15 (GO:0071350)3.44503006
75presynaptic membrane organization (GO:0097090)3.43499464
76virion attachment to host cell (GO:0019062)3.42143348
77adhesion of symbiont to host cell (GO:0044650)3.42143348
78negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.40517413
79regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.31671440
80immunoglobulin mediated immune response (GO:0016064)3.27516822
81synaptic vesicle maturation (GO:0016188)3.26702169
82negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.26679399
83B cell receptor signaling pathway (GO:0050853)3.26308332
84negative regulation of B cell mediated immunity (GO:0002713)3.24203076
85negative regulation of immunoglobulin mediated immune response (GO:0002890)3.24203076
86photoreceptor cell maintenance (GO:0045494)3.23545475
87positive regulation of mast cell activation (GO:0033005)3.21136139
88negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.20957383
89dendritic cell migration (GO:0036336)3.20915408
90negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.14100512
91positive regulation of cellular amide metabolic process (GO:0034250)3.13090068
92regulation of tolerance induction (GO:0002643)3.11400780
93antigen processing and presentation via MHC class Ib (GO:0002475)3.09585089
94regulation of short-term neuronal synaptic plasticity (GO:0048172)3.07790349
95regulation of synaptic vesicle transport (GO:1902803)3.06669520
96positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06555118
97regulation of mast cell activation (GO:0033003)3.05800010
98regulation of voltage-gated calcium channel activity (GO:1901385)3.05575960
99synaptic vesicle endocytosis (GO:0048488)3.05396227
100regulation of mast cell degranulation (GO:0043304)3.05052978
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.03083965
102negative regulation of T-helper cell differentiation (GO:0045623)3.03083965
103synaptic vesicle exocytosis (GO:0016079)3.02032468
104neuron cell-cell adhesion (GO:0007158)3.00287612
105regulation of macrophage cytokine production (GO:0010935)3.00002345
106fatty acid elongation (GO:0030497)2.99695208
107nerve growth factor signaling pathway (GO:0038180)2.98805298
108mating behavior (GO:0007617)2.98707118
109gamma-aminobutyric acid signaling pathway (GO:0007214)2.98367884
110glycerophospholipid catabolic process (GO:0046475)2.95410137
111regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94879427
112leukocyte degranulation (GO:0043299)2.93734378
113retinal cone cell development (GO:0046549)2.93482226
114peptidyl-tyrosine autophosphorylation (GO:0038083)2.92862703
115positive regulation of toll-like receptor signaling pathway (GO:0034123)2.91665213
116positive regulation of tolerance induction (GO:0002645)2.89579138
117myeloid leukocyte activation (GO:0002274)2.89528746
118regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89218822
119photoreceptor cell development (GO:0042461)2.88987920
120negative regulation of adaptive immune response (GO:0002820)2.88123646
121positive regulation of macrophage cytokine production (GO:0060907)2.88044823
122regulation of mast cell activation involved in immune response (GO:0033006)2.86929261
123regulation of B cell differentiation (GO:0045577)2.85866296
124dendritic cell chemotaxis (GO:0002407)2.83139508
125T-helper 1 type immune response (GO:0042088)2.82769743
126eye photoreceptor cell development (GO:0042462)2.82217842
127oligodendrocyte differentiation (GO:0048709)2.81927375
128response to redox state (GO:0051775)2.81689851
129regulation of interleukin-6 biosynthetic process (GO:0045408)2.80375985
130neutrophil chemotaxis (GO:0030593)2.78642944
131potassium ion homeostasis (GO:0055075)2.78392015
132response to lipoprotein particle (GO:0055094)2.77866081
133long-chain fatty acid biosynthetic process (GO:0042759)2.77284524
134negative T cell selection (GO:0043383)2.76310430
135regulation of interleukin-12 biosynthetic process (GO:0045075)2.75814706
136defense response to protozoan (GO:0042832)2.75045227
137positive regulation of interferon-alpha production (GO:0032727)2.74930204
138regulation of collateral sprouting (GO:0048670)2.74658028
139negative thymic T cell selection (GO:0045060)2.74322494
140interferon-gamma-mediated signaling pathway (GO:0060333)2.74177899
141positive regulation of B cell differentiation (GO:0045579)2.74042228
142negative regulation of interleukin-17 production (GO:0032700)2.73445911
143neutrophil migration (GO:1990266)2.73436453
144protein localization to synapse (GO:0035418)2.72123757
145adult walking behavior (GO:0007628)2.71248878
146macroautophagy (GO:0016236)2.70936418
147glutamate secretion (GO:0014047)2.70187834
148regulation of leukocyte degranulation (GO:0043300)2.69618497
149positive thymic T cell selection (GO:0045059)2.69167533
150positive regulation of oligodendrocyte differentiation (GO:0048714)2.68856914
151response to muramyl dipeptide (GO:0032495)2.68833896
152locomotory exploration behavior (GO:0035641)2.68781717
153regulation of interleukin-8 biosynthetic process (GO:0045414)2.68514599
154positive regulation of mast cell activation involved in immune response (GO:0033008)2.68404466
155L-serine transport (GO:0015825)2.67170529
156cerebellar Purkinje cell differentiation (GO:0021702)2.65418424
157regulation of beta-amyloid formation (GO:1902003)2.64614417
158transmission of nerve impulse (GO:0019226)2.62850305
159cerebellar granule cell differentiation (GO:0021707)2.62655631
160regulation of ARF protein signal transduction (GO:0032012)2.59566294
161adhesion of symbiont to host (GO:0044406)2.57254698
162phosphatidylinositol dephosphorylation (GO:0046856)2.56675442
163membrane hyperpolarization (GO:0060081)2.56628406
164phospholipid translocation (GO:0045332)2.55504306
165lipid translocation (GO:0034204)2.55504306
166vesicle transport along microtubule (GO:0047496)2.55152862
167leukocyte migration involved in inflammatory response (GO:0002523)2.53890828
168piRNA metabolic process (GO:0034587)2.53366803
169L-amino acid import (GO:0043092)2.51635718
170Leydig cell differentiation (GO:0033327)2.50129761
171long-term synaptic potentiation (GO:0060291)2.49425988
172protein localization to endosome (GO:0036010)2.48265209
173cyclic nucleotide catabolic process (GO:0009214)2.45807303
174cellular response to catecholamine stimulus (GO:0071870)2.43437557
175cellular response to monoamine stimulus (GO:0071868)2.43437557
176Golgi to endosome transport (GO:0006895)2.42400928
177regulation of neurotransmitter secretion (GO:0046928)2.42292081
178protein palmitoylation (GO:0018345)2.40272138
179regulation of amyloid precursor protein catabolic process (GO:1902991)2.39720904
180negative regulation of inclusion body assembly (GO:0090084)2.38339897
181positive regulation of potassium ion transport (GO:0043268)2.37390824
182potassium ion import (GO:0010107)2.37327587
183neuron-neuron synaptic transmission (GO:0007270)2.37185563
184astrocyte development (GO:0014002)2.35915123
185striatum development (GO:0021756)2.33703714
186serine transport (GO:0032329)2.33135821
187protein targeting to Golgi (GO:0000042)2.32925876
188phospholipid dephosphorylation (GO:0046839)2.32209745
189negative regulation of exocytosis (GO:0045920)2.31702777
190negative regulation of synaptic transmission (GO:0050805)2.31432355
191early endosome to late endosome transport (GO:0045022)2.30880962
192activated T cell proliferation (GO:0050798)2.30685341
193negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.30357256
194positive regulation of membrane potential (GO:0045838)2.29758241
195neuronal action potential propagation (GO:0019227)2.29536766
196response to pheromone (GO:0019236)2.29317523
197regulation of dendritic spine morphogenesis (GO:0061001)2.29071464
198neuron remodeling (GO:0016322)2.27148850

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.75694669
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.67901928
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.83883680
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.61047805
5GBX2_23144817_ChIP-Seq_PC3_Human3.36724088
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.10520274
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.01355887
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97199640
9RUNX_20019798_ChIP-Seq_JUKART_Human2.74658600
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.70138045
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.70004489
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.66940461
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.65613193
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64625031
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.51698157
16TAF15_26573619_Chip-Seq_HEK293_Human2.45979813
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41107735
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.33632925
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25429559
20* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.25037239
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.20336758
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.20171073
23* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.18240678
24SPI1_23547873_ChIP-Seq_NB4_Human2.15548189
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.03298796
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99693358
27VDR_24787735_ChIP-Seq_THP-1_Human1.98730107
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97489120
29MYB_26560356_Chip-Seq_TH2_Human1.95367747
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90341479
31SPI1_23127762_ChIP-Seq_K562_Human1.89118649
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88114638
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.84519876
34SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82109116
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.79906884
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.79702542
37DROSHA_22980978_ChIP-Seq_HELA_Human1.78477731
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77690242
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74103398
40ER_23166858_ChIP-Seq_MCF-7_Human1.72302468
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.71059529
42STAT3_23295773_ChIP-Seq_U87_Human1.69556072
43SMAD4_21799915_ChIP-Seq_A2780_Human1.68312643
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66999372
45* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.65629229
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.61258988
47* GATA3_27048872_Chip-Seq_THYMUS_Human1.61247559
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.58275535
49RARB_27405468_Chip-Seq_BRAIN_Mouse1.57183540
50SCL_19346495_ChIP-Seq_HPC-7_Human1.57167914
51* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56980880
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54897622
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.53885188
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.52154572
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.51765813
56PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51726645
57* P300_19829295_ChIP-Seq_ESCs_Human1.50764051
58STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50622839
59SALL1_21062744_ChIP-ChIP_HESCs_Human1.48772941
60FUS_26573619_Chip-Seq_HEK293_Human1.48210435
61TCF4_23295773_ChIP-Seq_U87_Human1.47204278
62MYB_26560356_Chip-Seq_TH1_Human1.44620429
63EZH2_22144423_ChIP-Seq_EOC_Human1.44461744
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.42876212
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42545093
66GATA3_26560356_Chip-Seq_TH2_Human1.41255040
67FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41141371
68BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40978061
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39786599
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39637737
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38596986
72REST_21632747_ChIP-Seq_MESCs_Mouse1.38397935
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37862773
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37655078
75NANOG_18555785_Chip-Seq_ESCs_Mouse1.37574570
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37179900
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.36569354
78TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35847069
79BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35328057
80PU_27001747_Chip-Seq_BMDM_Mouse1.34425588
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.33662684
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.33412979
83* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32778015
84NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32516649
85TP53_16413492_ChIP-PET_HCT116_Human1.30748622
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.30588784
87VDR_24763502_ChIP-Seq_THP-1_Human1.28906684
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.28425553
89SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.28306507
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28286843
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28286843
92TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27546450
93AHR_22903824_ChIP-Seq_MCF-7_Human1.26824060
94VDR_22108803_ChIP-Seq_LS180_Human1.26572408
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26041021
96AR_21572438_ChIP-Seq_LNCaP_Human1.25106543
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24145570
98AR_25329375_ChIP-Seq_VCAP_Human1.23146805
99SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22275360
100SUZ12_27294783_Chip-Seq_ESCs_Mouse1.21765902
101LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20437032
102GATA1_22025678_ChIP-Seq_K562_Human1.19940474
103JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19567514
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.18412022
105* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17735386
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.17000723
107GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15720811
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14322864
109LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14251441
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.12866120
111* CMYC_18555785_Chip-Seq_ESCs_Mouse1.12498916
112IGF1R_20145208_ChIP-Seq_DFB_Human1.12043697
113MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11536426
114EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09382283
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08426232
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.07879177
117EZH2_27304074_Chip-Seq_ESCs_Mouse1.07669457
118KDM2B_26808549_Chip-Seq_REH_Human1.07550422
119KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.07287634
120RNF2_27304074_Chip-Seq_NSC_Mouse1.06883597
121MAF_26560356_Chip-Seq_TH1_Human1.06065630
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.05280069
123SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05248691
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.05231963
125RUNX2_22187159_ChIP-Seq_PCA_Human1.05157471
126REST_18959480_ChIP-ChIP_MESCs_Mouse1.03528925
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03332171
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.03023454
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.02946218
130PRDM14_20953172_ChIP-Seq_ESCs_Human1.02939062
131WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02751606
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02705421
133STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02629283
134AR_19668381_ChIP-Seq_PC3_Human1.02482930
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02315004
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02064345
137* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01977435
138P300_18555785_Chip-Seq_ESCs_Mouse1.01450959
139FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00948784
140CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00734017
141PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00631805
142TAL1_26923725_Chip-Seq_HPCs_Mouse1.00190289
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00126676
144NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00126676
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99914702
146FLI1_27457419_Chip-Seq_LIVER_Mouse0.99800660
147SMRT_27268052_Chip-Seq_Bcells_Human0.99691103
148TBL1_22424771_ChIP-Seq_293T_Human0.99144279
149ESR1_20079471_ChIP-ChIP_T-47D_Human0.98154027
150P53_22387025_ChIP-Seq_ESCs_Mouse0.97139986
151GATA1_19941827_ChIP-Seq_MEL_Mouse0.96965471
152STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96151851
153RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.94277553
154NFE2_27457419_Chip-Seq_LIVER_Mouse0.94136520
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93089360
156* SALL4_22934838_ChIP-ChIP_CD34+_Human0.91461015
157* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90457933
158ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.90441960
159PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90394719
160* UTX_26944678_Chip-Seq_JUKART_Human0.90110354
161E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88586010
162OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87830601
163SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.86552242
164GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85126234
165BCAT_22108803_ChIP-Seq_LS180_Human0.83530051
166TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81027375
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.80209268
168* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78224213
169CRX_20693478_ChIP-Seq_RETINA_Mouse0.77953108
170* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76734743
171GATA2_19941826_ChIP-Seq_K562_Human0.75984657
172NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.75776192
173EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74887433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to6.51017556
2MP0005551_abnormal_eye_electrophysiolog4.41144665
3MP0003880_abnormal_central_pattern3.52762898
4MP0000920_abnormal_myelination3.49965027
5MP0003436_decreased_susceptibility_to3.41963633
6MP0001835_abnormal_antigen_presentation3.38476956
7MP0003950_abnormal_plasma_membrane3.26348407
8MP0006072_abnormal_retinal_apoptosis3.25194413
9MP0003303_peritoneal_inflammation3.09903673
10MP0005253_abnormal_eye_physiology3.07183356
11MP0003828_pulmonary_edema3.04512811
12MP0002419_abnormal_innate_immunity2.95676536
13MP0004859_abnormal_synaptic_plasticity2.93746796
14MP0004270_analgesia2.80490802
15MP0004885_abnormal_endolymph2.76625139
16MP0009785_altered_susceptibility_to2.75807155
17MP0000569_abnormal_digit_pigmentation2.72636465
18MP0003183_abnormal_peptide_metabolism2.66429166
19MP0001800_abnormal_humoral_immune2.52924729
20MP0005025_abnormal_response_to2.45619605
21MP0001984_abnormal_olfaction2.38394168
22MP0006082_CNS_inflammation2.37209539
23MP0001529_abnormal_vocalization2.34578670
24MP0005000_abnormal_immune_tolerance2.33573622
25MP0005671_abnormal_response_to2.31660880
26MP0003635_abnormal_synaptic_transmissio2.28056985
27MP0000685_abnormal_immune_system2.22785284
28MP0009046_muscle_twitch2.22723788
29MP0002723_abnormal_immune_serum2.21381458
30MP0002272_abnormal_nervous_system2.20362229
31MP0000465_gastrointestinal_hemorrhage2.17159025
32MP0002420_abnormal_adaptive_immunity2.15954176
33MP0003329_amyloid_beta_deposits2.15347613
34MP0002452_abnormal_antigen_presenting2.14940305
35MP0002064_seizures2.14587790
36MP0002229_neurodegeneration2.13025689
37MP0001819_abnormal_immune_cell2.12943536
38MP0003300_gastrointestinal_ulcer2.09158647
39MP0003690_abnormal_glial_cell2.09129615
40MP0005387_immune_system_phenotype2.07960308
41MP0001790_abnormal_immune_system2.07960308
42MP0001486_abnormal_startle_reflex2.04177314
43MP0009745_abnormal_behavioral_response2.00762892
44MP0001533_abnormal_skeleton_physiology1.99462192
45MP0003011_delayed_dark_adaptation1.98135321
46MP0003634_abnormal_glial_cell1.94587450
47MP0003787_abnormal_imprinting1.91123288
48MP0005195_abnormal_posterior_eye1.90183205
49MP0004883_abnormal_blood_vessel1.87526431
50MP0002405_respiratory_system_inflammati1.82261973
51MP0005464_abnormal_platelet_physiology1.80806891
52MP0002148_abnormal_hypersensitivity_rea1.76712735
53MP0002063_abnormal_learning/memory/cond1.75150072
54MP0001661_extended_life_span1.73887140
55MP0000778_abnormal_nervous_system1.69937737
56MP0004043_abnormal_pH_regulation1.68794102
57MP0009780_abnormal_chondrocyte_physiolo1.67226638
58MP0002734_abnormal_mechanical_nocicepti1.66054761
59MP0003632_abnormal_nervous_system1.61684074
60MP0002132_abnormal_respiratory_system1.60747439
61MP0003763_abnormal_thymus_physiology1.59084161
62MP0009764_decreased_sensitivity_to1.58415128
63MP0002090_abnormal_vision1.57232889
64MP0001845_abnormal_inflammatory_respons1.56921270
65MP0000716_abnormal_immune_system1.54788159
66MP0000604_amyloidosis1.54554722
67MP0002398_abnormal_bone_marrow1.50321770
68MP0004484_altered_response_of1.49825317
69MP0001502_abnormal_circadian_rhythm1.48622496
70MP0008877_abnormal_DNA_methylation1.47205448
71MP0003172_abnormal_lysosome_physiology1.47192193
72MP0004924_abnormal_behavior1.45571692
73MP0005386_behavior/neurological_phenoty1.45571692
74MP0002882_abnormal_neuron_morphology1.45543896
75MP0004742_abnormal_vestibular_system1.45070297
76MP0005164_abnormal_response_to1.43234414
77MP0010234_abnormal_vibrissa_follicle1.40696018
78MP0002166_altered_tumor_susceptibility1.36573915
79MP0000689_abnormal_spleen_morphology1.35842883
80MP0001346_abnormal_lacrimal_gland1.35772168
81MP0002572_abnormal_emotion/affect_behav1.34728844
82MP0001177_atelectasis1.34079262
83MP0008004_abnormal_stomach_pH1.33884464
84MP0000013_abnormal_adipose_tissue1.33562619
85MP0002722_abnormal_immune_system1.32244148
86MP0005410_abnormal_fertilization1.31876347
87MP0010155_abnormal_intestine_physiology1.31835634
88MP0005397_hematopoietic_system_phenotyp1.31159452
89MP0001545_abnormal_hematopoietic_system1.31159452
90MP0003656_abnormal_erythrocyte_physiolo1.30876358
91MP0002909_abnormal_adrenal_gland1.30768131
92MP0002067_abnormal_sensory_capabilities1.30455592
93MP0003075_altered_response_to1.30290137
94MP0010386_abnormal_urinary_bladder1.28778946
95MP0001501_abnormal_sleep_pattern1.28590681
96MP0005171_absent_coat_pigmentation1.27964382
97MP0005391_vision/eye_phenotype1.27908964
98MP0010678_abnormal_skin_adnexa1.24715118
99MP0002332_abnormal_exercise_endurance1.23890781
100MP0002638_abnormal_pupillary_reflex1.23703578
101MP0004381_abnormal_hair_follicle1.23239362
102MP0003221_abnormal_cardiomyocyte_apopto1.22916636
103MP0003866_abnormal_defecation1.22695540
104MP0000462_abnormal_digestive_system1.22608739
105MP0003631_nervous_system_phenotype1.20431312
106MP0004130_abnormal_muscle_cell1.19946642
107MP0002752_abnormal_somatic_nervous1.19911772
108MP0005166_decreased_susceptibility_to1.19544433
109MP0008469_abnormal_protein_level1.19514549
110MP0001970_abnormal_pain_threshold1.18408496
111MP0004947_skin_inflammation1.18403095
112MP0008569_lethality_at_weaning1.17521357
113MP0002277_abnormal_respiratory_mucosa1.17038473
114MP0001324_abnormal_eye_pigmentation1.16249288
115MP0005310_abnormal_salivary_gland1.13088442
116MP0002429_abnormal_blood_cell1.11773245
117MP0000955_abnormal_spinal_cord1.10970706
118MP0009278_abnormal_bone_marrow1.09838625
119MP0002998_abnormal_bone_remodeling1.08542392
120MP0000858_altered_metastatic_potential1.06746745
121MP0005423_abnormal_somatic_nervous1.05104654
122MP0003633_abnormal_nervous_system1.05089911
123MP0000703_abnormal_thymus_morphology1.04980475
124MP0001963_abnormal_hearing_physiology1.04904877
125MP0005645_abnormal_hypothalamus_physiol1.04657883
126MP0004782_abnormal_surfactant_physiolog1.04187639
127MP0001440_abnormal_grooming_behavior1.04129060
128MP0008260_abnormal_autophagy1.03494403
129MP0005451_abnormal_body_composition1.01959738
130MP0001905_abnormal_dopamine_level1.01599374
131MP0003045_fibrosis1.01313063
132MP0002066_abnormal_motor_capabilities/c1.01014370
133MP0002733_abnormal_thermal_nociception1.00702519
134MP0006054_spinal_hemorrhage1.00011421
135MP0005075_abnormal_melanosome_morpholog0.99893782
136MP0003121_genomic_imprinting0.96668607
137MP0000427_abnormal_hair_cycle0.96544698
138MP0005646_abnormal_pituitary_gland0.96257143
139MP0003191_abnormal_cellular_cholesterol0.94660014
140MP0004084_abnormal_cardiac_muscle0.93046648
141MP0000015_abnormal_ear_pigmentation0.91966561
142MP0000343_altered_response_to0.91816753
143MP0001968_abnormal_touch/_nociception0.90259426
144MP0001299_abnormal_eye_distance/0.89980220
145MP0003448_altered_tumor_morphology0.89261227
146MP0009763_increased_sensitivity_to0.89111213
147MP0001851_eye_inflammation0.88508030
148MP0003698_abnormal_male_reproductive0.87966048
149MP0002396_abnormal_hematopoietic_system0.87879082
150MP0000631_abnormal_neuroendocrine_gland0.87647357
151MP0000249_abnormal_blood_vessel0.87314689
152MP0002006_tumorigenesis0.84233484
153MP0001958_emphysema0.82223475
154MP0004510_myositis0.82202392
155MP0005058_abnormal_lysosome_morphology0.81599504
156MP0002152_abnormal_brain_morphology0.80805911
157MP0001485_abnormal_pinna_reflex0.76923432
158MP0002557_abnormal_social/conspecific_i0.76917133
159MP0004811_abnormal_neuron_physiology0.75240584
160MP0002184_abnormal_innervation0.73456858
161MP0002138_abnormal_hepatobiliary_system0.72447277
162MP0005376_homeostasis/metabolism_phenot0.71357738
163MP0003252_abnormal_bile_duct0.69379960
164MP0002822_catalepsy0.69185726
165MP0009765_abnormal_xenobiotic_induced0.68686190
166MP0004036_abnormal_muscle_relaxation0.68585609
167MP0000003_abnormal_adipose_tissue0.68141753
168MP0003091_abnormal_cell_migration0.68090143
169MP0005167_abnormal_blood-brain_barrier0.67408875
170MP0005388_respiratory_system_phenotype0.66866743
171MP0002133_abnormal_respiratory_system0.66866743
172MP0004233_abnormal_muscle_weight0.66452009
173MP0003646_muscle_fatigue0.66304197
174MP0002971_abnormal_brown_adipose0.65685160
175MP0002837_dystrophic_cardiac_calcinosis0.63411652
176MP0005499_abnormal_olfactory_system0.62971295
177MP0005394_taste/olfaction_phenotype0.62971295
178MP0005535_abnormal_body_temperature0.62581434
179MP0005390_skeleton_phenotype0.62491949
180MP0005174_abnormal_tail_pigmentation0.61677861
181MP0008874_decreased_physiological_sensi0.59347753
182MP0001853_heart_inflammation0.58084699

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.13382704
2Congenital stationary night blindness (HP:0007642)5.93778608
3Recurrent bacterial skin infections (HP:0005406)5.92803290
4Recurrent abscess formation (HP:0002722)5.77304713
5Myositis (HP:0100614)5.42163285
6Optic neuritis (HP:0100653)5.26832337
7Retrobulbar optic neuritis (HP:0100654)5.26832337
8Orchitis (HP:0100796)5.26254652
9Central scotoma (HP:0000603)4.91664642
10Recurrent gram-negative bacterial infections (HP:0005420)4.83372644
11Abnormality of macular pigmentation (HP:0008002)4.63840356
12Degeneration of the lateral corticospinal tracts (HP:0002314)4.59120022
13Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.59120022
14Abnormality of macrophages (HP:0004311)4.48548949
15Bony spicule pigmentary retinopathy (HP:0007737)4.46880131
16Gastrointestinal infarctions (HP:0005244)4.35320968
17Neurofibrillary tangles (HP:0002185)4.31429775
18Stomatitis (HP:0010280)4.23469762
19Keratoconjunctivitis sicca (HP:0001097)4.08718745
20Elevated erythrocyte sedimentation rate (HP:0003565)3.98509084
21Recurrent fungal infections (HP:0002841)3.93322934
22Recurrent skin infections (HP:0001581)3.89477685
23Abolished electroretinogram (ERG) (HP:0000550)3.81551699
24Keratoconjunctivitis (HP:0001096)3.79177000
25T lymphocytopenia (HP:0005403)3.75014981
26Abnormality of the corticospinal tract (HP:0002492)3.73224707
27Dyschromatopsia (HP:0007641)3.60152394
28Cone-rod dystrophy (HP:0000548)3.58040241
29Gingivitis (HP:0000230)3.58012368
30Abnormality of T cell number (HP:0011839)3.55798602
31Chronic mucocutaneous candidiasis (HP:0002728)3.55027900
32Recurrent cutaneous fungal infections (HP:0011370)3.55027900
33Mediastinal lymphadenopathy (HP:0100721)3.54656900
34Choroideremia (HP:0001139)3.53843678
35Scotoma (HP:0000575)3.53580540
36Abnormal rod and cone electroretinograms (HP:0008323)3.49581694
37Spontaneous hematomas (HP:0007420)3.46711580
38Hypochromic microcytic anemia (HP:0004840)3.45724030
39Encephalitis (HP:0002383)3.45037907
40Decreased central vision (HP:0007663)3.42543734
41Gingival bleeding (HP:0000225)3.37398677
42Meningitis (HP:0001287)3.33388440
43Cerebral inclusion bodies (HP:0100314)3.31469486
44Abnormal delayed hypersensitivity skin test (HP:0002963)3.30218723
45Chest pain (HP:0100749)3.28549689
46Spastic gait (HP:0002064)3.24450846
47Amyloidosis (HP:0011034)3.14749790
48Arterial thrombosis (HP:0004420)3.14433130
49Obstructive lung disease (HP:0006536)3.06774017
50Chronic obstructive pulmonary disease (HP:0006510)3.06774017
51Hemoptysis (HP:0002105)3.04345489
52Pigmentary retinal degeneration (HP:0001146)3.00196587
53Peritonitis (HP:0002586)2.99754206
54Epileptic encephalopathy (HP:0200134)2.99476964
55Supranuclear gaze palsy (HP:0000605)2.99264590
56Urticaria (HP:0001025)2.97490896
57Leukocytosis (HP:0001974)2.96888775
58Vasculitis (HP:0002633)2.96582094
59Sensory axonal neuropathy (HP:0003390)2.92531826
60Ankle clonus (HP:0011448)2.83156602
61Pulmonary infiltrates (HP:0002113)2.82847283
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.82664768
63Atonic seizures (HP:0010819)2.79202935
64Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.78315042
65Chorioretinal atrophy (HP:0000533)2.76716815
66Pulmonary embolism (HP:0002204)2.73889770
67Intention tremor (HP:0002080)2.67222137
68Episodic fever (HP:0001954)2.64998361
69Prolonged bleeding time (HP:0003010)2.64350558
70Volvulus (HP:0002580)2.64240123
71Oligodactyly (hands) (HP:0001180)2.62831298
72Anorexia (HP:0002039)2.61762428
73Dysmetria (HP:0001310)2.60786753
74Epistaxis (HP:0000421)2.58623271
75Abnormality of T cells (HP:0002843)2.52977425
76Macular degeneration (HP:0000608)2.50410092
77Muscle fiber splitting (HP:0003555)2.50111440
78Papillary thyroid carcinoma (HP:0002895)2.44887235
79Attenuation of retinal blood vessels (HP:0007843)2.43580358
80Osteomyelitis (HP:0002754)2.43532373
81Thickened helices (HP:0000391)2.43131818
82Scanning speech (HP:0002168)2.40767353
83Gangrene (HP:0100758)2.40620748
84Keratoconus (HP:0000563)2.39291874
85Increased corneal curvature (HP:0100692)2.39291874
86Vaginal atresia (HP:0000148)2.38505028
87Widely spaced teeth (HP:0000687)2.37616842
88Cellulitis (HP:0100658)2.37578360
89Difficulty running (HP:0009046)2.37401723
90Onion bulb formation (HP:0003383)2.37139239
91Gait imbalance (HP:0002141)2.36335329
92Vertigo (HP:0002321)2.35005574
93Lower limb muscle weakness (HP:0007340)2.33656089
94Gaze-evoked nystagmus (HP:0000640)2.29672434
95Abnormal auditory evoked potentials (HP:0006958)2.29659104
96Genital tract atresia (HP:0001827)2.29494758
97Type II diabetes mellitus (HP:0005978)2.29471205
98Nephrogenic diabetes insipidus (HP:0009806)2.28320200
99Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26641805
100Eosinophilia (HP:0001880)2.26245675
101Retinitis pigmentosa (HP:0000510)2.25583244
102Inflammation of the large intestine (HP:0002037)2.24440515
103Photophobia (HP:0000613)2.23656818
104Congenital primary aphakia (HP:0007707)2.23029429
105Recurrent viral infections (HP:0004429)2.22449960
106Focal motor seizures (HP:0011153)2.19674532
107Clonus (HP:0002169)2.17304881
108Recurrent bronchitis (HP:0002837)2.16502746
109Papilledema (HP:0001085)2.16366688
110Acute hepatic failure (HP:0006554)2.15936146
111Medial flaring of the eyebrow (HP:0010747)2.15927412
112Microcytic anemia (HP:0001935)2.15051162
113Periodontitis (HP:0000704)2.14314379
114Absence seizures (HP:0002121)2.13282140
115Septo-optic dysplasia (HP:0100842)2.13126875
116Hypochromic anemia (HP:0001931)2.12545488
117Abnormality of eosinophils (HP:0001879)2.11174839
118Urinary urgency (HP:0000012)2.11148663
119Granulocytopenia (HP:0001913)2.10995163
120Panhypogammaglobulinemia (HP:0003139)2.09656384
121Truncal ataxia (HP:0002078)2.09580807
122Increased IgE level (HP:0003212)2.08805428
123Abnormality of the pleura (HP:0002103)2.08450152
124Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.08230537
125Aqueductal stenosis (HP:0002410)2.07831873
126Progressive cerebellar ataxia (HP:0002073)2.07068041
127Myokymia (HP:0002411)2.06896754
128Retinal dysplasia (HP:0007973)2.06559822
129Abnormality of the endocardium (HP:0004306)2.05575867
130Hemiplegia (HP:0002301)2.03689850
131Thrombophlebitis (HP:0004418)2.02506765
132Abnormality of the peritoneum (HP:0002585)2.02502225
133Sepsis (HP:0100806)2.02198655
134Amaurosis fugax (HP:0100576)2.01193344
135Gastrointestinal inflammation (HP:0004386)1.99580470
136IgM deficiency (HP:0002850)1.99153013
137Polyneuropathy (HP:0001271)1.98285070
138Pendular nystagmus (HP:0012043)1.96947530
139Type II lissencephaly (HP:0007260)1.95952299
140Keratitis (HP:0000491)1.94970478
141Excessive salivation (HP:0003781)1.93626494
142Drooling (HP:0002307)1.93626494
143Blue irides (HP:0000635)1.93122873
144Dialeptic seizures (HP:0011146)1.92206424
145Glomerulopathy (HP:0100820)1.91048033
146Stomach cancer (HP:0012126)1.90913869
147Abnormality of the labia minora (HP:0012880)1.90239741
148Abnormal platelet volume (HP:0011876)1.89895972
149Absent speech (HP:0001344)1.89602383
150Slow saccadic eye movements (HP:0000514)1.89599554
151Abnormality of the salivary glands (HP:0010286)1.88205967
152Epileptiform EEG discharges (HP:0011182)1.87900699
153Urinary bladder sphincter dysfunction (HP:0002839)1.87734952
154Colitis (HP:0002583)1.86927862
155Amyotrophic lateral sclerosis (HP:0007354)1.86329839
156Abnormality of the periventricular white matter (HP:0002518)1.85437024
157EEG with generalized epileptiform discharges (HP:0011198)1.84758238
158Thyroiditis (HP:0100646)1.83830771
159Gastrointestinal stroma tumor (HP:0100723)1.83677273
160Subacute progressive viral hepatitis (HP:0006572)1.83079153
161Specific learning disability (HP:0001328)1.82267449
162Stenosis of the external auditory canal (HP:0000402)1.81972647
163Clumsiness (HP:0002312)1.81328259
164Hematochezia (HP:0002573)1.80711800
165Insidious onset (HP:0003587)1.80703335
166Termporal pattern (HP:0011008)1.80703335
167Akinesia (HP:0002304)1.79642636
168Viral hepatitis (HP:0006562)1.79173925
169Focal seizures (HP:0007359)1.78969752
170Febrile seizures (HP:0002373)1.78925646
171Increased CSF protein (HP:0002922)1.77643534
172Disinhibition (HP:0000734)1.76576326
173Labial hypoplasia (HP:0000066)1.76339388
174Resting tremor (HP:0002322)1.75708787
175Premature loss of primary teeth (HP:0006323)1.74645758
176Progressive visual loss (HP:0000529)1.74428588
177Anteriorly placed anus (HP:0001545)1.73333316
178Toxemia of pregnancy (HP:0100603)1.73061124
179Peripheral hypomyelination (HP:0007182)1.71584795
180Abnormality of T cell physiology (HP:0011840)1.71196142
181Poor coordination (HP:0002370)1.70338747
182Hyporeflexia of lower limbs (HP:0002600)1.70300378
183Progressive inability to walk (HP:0002505)1.69833891
184Postural instability (HP:0002172)1.68088520
185Cerebral hypomyelination (HP:0006808)1.67936898
186Acne (HP:0001061)1.67650089
187Megalencephaly (HP:0001355)1.67644538
188Paresthesia (HP:0003401)1.67309694
189Recurrent pneumonia (HP:0006532)1.67002936
190Chronic otitis media (HP:0000389)1.66729985
191Poor speech (HP:0002465)1.66231437
192Facial diplegia (HP:0001349)1.65572299
193Hypoplastic female external genitalia (HP:0012815)1.61540574
194Severe visual impairment (HP:0001141)1.60887369
195Alacrima (HP:0000522)1.60304454
196Cortical dysplasia (HP:0002539)1.59232240
197Thyroid carcinoma (HP:0002890)1.59121889
198Action tremor (HP:0002345)1.57871601

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.47839065
2OXSR13.59810926
3BLK3.23585306
4MAP3K132.66459952
5BCR2.59219644
6MAP2K32.57407214
7IRAK42.55935816
8PAK62.49051684
9TYK22.43288977
10PBK2.26419601
11KSR22.24945159
12FGFR22.23125748
13MAP3K92.11156625
14EPHB12.10937227
15TXK2.05875245
16GRK61.98701700
17PRPF4B1.95696899
18WNK11.94302778
19MAP4K11.92928198
20PKN11.91225379
21WNK41.83266585
22MAP3K41.80981491
23ZAP701.75419642
24EPHA41.71630641
25NTRK11.68586600
26IKBKE1.67884692
27TNK21.63026303
28JAK21.62891654
29HCK1.60948292
30JAK11.60856445
31FGR1.59908003
32JAK31.58601444
33SYK1.57951189
34MET1.56381323
35YES11.55694151
36FRK1.55080816
37NEK61.53943241
38TAOK31.53704693
39PIK3CG1.53144761
40TGFBR21.52907445
41SGK2231.52333642
42SGK4941.52333642
43BTK1.51987671
44CDK191.49647364
45CSNK1A1L1.44536427
46MAP3K141.39377798
47INSRR1.38522129
48LYN1.37757021
49KSR11.34170109
50MAP3K31.33232120
51CAMK2B1.32689121
52CLK11.30593514
53CSNK1G31.26503395
54TEC1.24800108
55KIT1.24360780
56MST41.23497034
57RIPK41.18656433
58TAOK11.18215596
59CASK1.18197569
60GRK11.18063457
61CSNK1G21.17577821
62BCKDK1.15040208
63NTRK31.14712708
64ACVR1B1.14440707
65CAMK1D1.13532156
66IRAK11.13356409
67CAMK1G1.13340207
68MAP3K11.11984441
69CAMK2D1.11327714
70MAP3K21.10619407
71ICK1.08264724
72TBK11.04706646
73MAP3K51.04084146
74LCK1.03689348
75PTK2B1.03652522
76CDK51.01006327
77TYRO31.00422799
78MELK0.99016994
79PDK40.98309237
80PDK30.98309237
81ROCK20.97785130
82MARK30.96841380
83OBSCN0.96663957
84CSNK1G10.93668161
85NLK0.93663540
86MARK10.92793296
87FGFR30.87348391
88MATK0.84854691
89WNK30.83643124
90PDK20.83177508
91UHMK10.80833680
92IRAK20.80242261
93LIMK10.77070360
94CAMKK20.76947580
95MAP2K70.76641135
96NTRK20.76511561
97PDPK10.75348087
98ERN10.75215541
99PDK10.74485052
100ERBB30.73810383
101SIK30.70857113
102CAMK2A0.69652078
103DYRK1B0.69188052
104PRKCH0.67914687
105MAPK70.67748605
106MAPK120.67110119
107NEK90.65591398
108STK100.65561099
109PRKCQ0.64825507
110SGK10.63309517
111DAPK20.63159244
112MAP3K60.63075124
113PRKCE0.61172113
114FYN0.61049897
115PAK30.60485687
116LRRK20.60061224
117CAMK2G0.59439993
118STK110.59050627
119MAP3K70.58831709
120GRK50.58376449
121BMPR20.56498908
122GRK70.55771449
123PLK20.54379406
124MARK20.54210393
125MAPK100.53269526
126PRKD30.53090946
127PDGFRB0.52764925
128ITK0.51256235
129PIM10.50900253
130DYRK1A0.50420826
131RAF10.50328647
132FES0.50169423
133CDK140.50113760
134MAP3K110.49386439
135RET0.49123988
136CSNK1D0.47889157
137CDK60.47655407
138EPHA30.47397439
139STK380.47353403
140SGK20.47288081
141EIF2AK30.47139221
142PINK10.46770727
143MINK10.46736658
144CSK0.46507463
145MAP4K20.46193598
146EGFR0.45674555
147MAP3K120.45326053
148SGK30.45118060
149CDK150.44875255
150CDK180.44735912
151BMPR1B0.42955611
152CSF1R0.42541131
153ARAF0.42278469
154CAMK40.41853167
155TRPM70.41395298
156AKT30.40952531
157MOS0.40792547
158MAPKAPK50.39910118
159PNCK0.37277027
160MAP2K40.37132741
161PRKAA20.35167292
162FER0.34861953
163RPS6KA30.34681643

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.53436245
2Leishmaniasis_Homo sapiens_hsa051403.22455659
3Osteoclast differentiation_Homo sapiens_hsa043802.95589475
4Staphylococcus aureus infection_Homo sapiens_hsa051502.91234057
5Synaptic vesicle cycle_Homo sapiens_hsa047212.30339950
6GABAergic synapse_Homo sapiens_hsa047272.26509381
7Morphine addiction_Homo sapiens_hsa050322.23945218
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.19681516
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.15577471
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09482374
11Nicotine addiction_Homo sapiens_hsa050332.06178027
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98897101
13Malaria_Homo sapiens_hsa051441.91220366
14Legionellosis_Homo sapiens_hsa051341.88408655
15Glutamatergic synapse_Homo sapiens_hsa047241.83789838
16Graft-versus-host disease_Homo sapiens_hsa053321.81959195
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80224661
18Circadian entrainment_Homo sapiens_hsa047131.76746866
19Allograft rejection_Homo sapiens_hsa053301.72192411
20Olfactory transduction_Homo sapiens_hsa047401.71320800
21Autoimmune thyroid disease_Homo sapiens_hsa053201.69346136
22Hematopoietic cell lineage_Homo sapiens_hsa046401.66479193
23Measles_Homo sapiens_hsa051621.64361216
24Primary immunodeficiency_Homo sapiens_hsa053401.60276486
25Renin secretion_Homo sapiens_hsa049241.59124614
26Salivary secretion_Homo sapiens_hsa049701.57321189
27Dopaminergic synapse_Homo sapiens_hsa047281.55600974
28Serotonergic synapse_Homo sapiens_hsa047261.54012810
29Collecting duct acid secretion_Homo sapiens_hsa049661.50636148
30Long-term potentiation_Homo sapiens_hsa047201.46249376
31T cell receptor signaling pathway_Homo sapiens_hsa046601.44630891
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.44309168
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.44045693
34Ether lipid metabolism_Homo sapiens_hsa005651.42695260
35Toxoplasmosis_Homo sapiens_hsa051451.42449302
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.41238934
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.41156481
38Cholinergic synapse_Homo sapiens_hsa047251.37817562
39Vibrio cholerae infection_Homo sapiens_hsa051101.37204770
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.37080544
41RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36739245
42Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33464882
43Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32799142
44Long-term depression_Homo sapiens_hsa047301.32361293
45Type I diabetes mellitus_Homo sapiens_hsa049401.31960602
46Insulin secretion_Homo sapiens_hsa049111.31344559
47Amphetamine addiction_Homo sapiens_hsa050311.29152089
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.29069112
49Dorso-ventral axis formation_Homo sapiens_hsa043201.28749697
50Platelet activation_Homo sapiens_hsa046111.27974421
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.27531981
52Antigen processing and presentation_Homo sapiens_hsa046121.25330327
53Influenza A_Homo sapiens_hsa051641.25191306
54Cocaine addiction_Homo sapiens_hsa050301.20852372
55Renal cell carcinoma_Homo sapiens_hsa052111.20770486
56Alcoholism_Homo sapiens_hsa050341.20503201
57Pertussis_Homo sapiens_hsa051331.19282195
58Axon guidance_Homo sapiens_hsa043601.18736210
59Inositol phosphate metabolism_Homo sapiens_hsa005621.18610421
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18380065
61Viral myocarditis_Homo sapiens_hsa054161.16196067
62Sphingolipid metabolism_Homo sapiens_hsa006001.16156620
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14607673
64Acute myeloid leukemia_Homo sapiens_hsa052211.12993629
65Oxytocin signaling pathway_Homo sapiens_hsa049211.11337831
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.09917739
67Gastric acid secretion_Homo sapiens_hsa049711.09847359
68Type II diabetes mellitus_Homo sapiens_hsa049301.09473025
69Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.06966977
70Regulation of autophagy_Homo sapiens_hsa041401.02188074
71Endocytosis_Homo sapiens_hsa041441.01999055
72TNF signaling pathway_Homo sapiens_hsa046681.01931541
73cAMP signaling pathway_Homo sapiens_hsa040241.00355636
74Phospholipase D signaling pathway_Homo sapiens_hsa040721.00319966
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99835201
76Herpes simplex infection_Homo sapiens_hsa051680.98172166
77Mineral absorption_Homo sapiens_hsa049780.98162491
78Non-small cell lung cancer_Homo sapiens_hsa052230.97882517
79Taste transduction_Homo sapiens_hsa047420.97026163
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95976766
81Hepatitis B_Homo sapiens_hsa051610.95234770
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94800687
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.93970166
84Hepatitis C_Homo sapiens_hsa051600.93840744
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93193135
86African trypanosomiasis_Homo sapiens_hsa051430.91129705
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89855928
88Pancreatic secretion_Homo sapiens_hsa049720.89643715
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88992733
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.88682572
91Chemokine signaling pathway_Homo sapiens_hsa040620.87751771
92Estrogen signaling pathway_Homo sapiens_hsa049150.86679611
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86221056
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86067941
95ErbB signaling pathway_Homo sapiens_hsa040120.85778330
96Asthma_Homo sapiens_hsa053100.85481348
97Prolactin signaling pathway_Homo sapiens_hsa049170.84704954
98FoxO signaling pathway_Homo sapiens_hsa040680.83754253
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83683235
100GnRH signaling pathway_Homo sapiens_hsa049120.82448535
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80493237
102Choline metabolism in cancer_Homo sapiens_hsa052310.80320000
103Rheumatoid arthritis_Homo sapiens_hsa053230.80265004
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.79102648
105Sulfur metabolism_Homo sapiens_hsa009200.78973774
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.78195930
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.78183311
108Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77474875
109Circadian rhythm_Homo sapiens_hsa047100.76385814
110Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76187708
111Lysosome_Homo sapiens_hsa041420.75387893
112Amoebiasis_Homo sapiens_hsa051460.72015182
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.70943931
114Tight junction_Homo sapiens_hsa045300.70008951
115Gap junction_Homo sapiens_hsa045400.69070330
116B cell receptor signaling pathway_Homo sapiens_hsa046620.67666144
117Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67637220
118MAPK signaling pathway_Homo sapiens_hsa040100.67334858
119Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67240935
120AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66890659
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66819785
122Phagosome_Homo sapiens_hsa041450.66469537
123Thyroid hormone synthesis_Homo sapiens_hsa049180.65693486
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64474776
125Ovarian steroidogenesis_Homo sapiens_hsa049130.63384999
126Ras signaling pathway_Homo sapiens_hsa040140.62777216
127Apoptosis_Homo sapiens_hsa042100.62008891
128Calcium signaling pathway_Homo sapiens_hsa040200.61213416
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.59542785
130Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58380748
131Melanogenesis_Homo sapiens_hsa049160.57917088
132Oocyte meiosis_Homo sapiens_hsa041140.56691214
133Endometrial cancer_Homo sapiens_hsa052130.55922384
134Glycerophospholipid metabolism_Homo sapiens_hsa005640.53722708
135Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52316658
136Glycerolipid metabolism_Homo sapiens_hsa005610.51941489
137VEGF signaling pathway_Homo sapiens_hsa043700.50090806
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49743357
139HIF-1 signaling pathway_Homo sapiens_hsa040660.48998122
140Salmonella infection_Homo sapiens_hsa051320.48002059
141Chronic myeloid leukemia_Homo sapiens_hsa052200.46775831
142Insulin resistance_Homo sapiens_hsa049310.46253086
143Glioma_Homo sapiens_hsa052140.44382510
144Complement and coagulation cascades_Homo sapiens_hsa046100.44200389
145Colorectal cancer_Homo sapiens_hsa052100.43645262
146Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43331655
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.41324118
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40777868
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38611044
150Fatty acid elongation_Homo sapiens_hsa000620.38586242
151mTOR signaling pathway_Homo sapiens_hsa041500.38314417
152PPAR signaling pathway_Homo sapiens_hsa033200.36546855
153Pancreatic cancer_Homo sapiens_hsa052120.36162234
154Systemic lupus erythematosus_Homo sapiens_hsa053220.35764534
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35733970
156Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35095888
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35000827
158Rap1 signaling pathway_Homo sapiens_hsa040150.34800405
159Shigellosis_Homo sapiens_hsa051310.34671334
160Steroid biosynthesis_Homo sapiens_hsa001000.34426531
161Tuberculosis_Homo sapiens_hsa051520.33536780
162Wnt signaling pathway_Homo sapiens_hsa043100.33526956

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