FBXL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that are characterized by an F-box motif. The encoded protein also contains leucine-rich repeats. F-box-containing proteins comprise one of the subunits of the SCF (SKP1-cullin-F-box) complex, which functions in phosphorylation-dependent ubiquitination. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.99730469
2DNA deamination (GO:0045006)7.63552869
3transcription from mitochondrial promoter (GO:0006390)7.22132914
4proline metabolic process (GO:0006560)6.65707023
5replication fork processing (GO:0031297)6.42794808
6embryonic process involved in female pregnancy (GO:0060136)6.07946062
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.74331543
8positive regulation of protein homooligomerization (GO:0032464)5.61430636
9somatic diversification of immune receptors via somatic mutation (GO:0002566)5.01271362
10somatic hypermutation of immunoglobulin genes (GO:0016446)5.01271362
11mitochondrial DNA metabolic process (GO:0032042)4.99464488
12telomere maintenance via semi-conservative replication (GO:0032201)4.91344172
13regulation of protein homooligomerization (GO:0032462)4.82907538
14oxidative demethylation (GO:0070989)4.82444122
15establishment of apical/basal cell polarity (GO:0035089)4.80303089
16formation of translation preinitiation complex (GO:0001731)4.76286240
17viral mRNA export from host cell nucleus (GO:0046784)4.74456376
18regulation of integrin activation (GO:0033623)4.67195255
19mitotic G1 DNA damage checkpoint (GO:0031571)4.62755974
20poly(A)+ mRNA export from nucleus (GO:0016973)4.45484473
21mannose metabolic process (GO:0006013)4.43255593
22DNA strand renaturation (GO:0000733)4.40825202
23DNA strand elongation involved in DNA replication (GO:0006271)4.35657643
24activation of Rac GTPase activity (GO:0032863)4.33908770
25negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.33198092
26base-excision repair (GO:0006284)4.30700851
27negative regulation of erythrocyte differentiation (GO:0045647)4.30225011
28pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.24254783
29nucleotide-excision repair, DNA gap filling (GO:0006297)4.14410671
30regulation of translational fidelity (GO:0006450)4.12677003
31DNA strand elongation (GO:0022616)4.11934830
32base-excision repair, AP site formation (GO:0006285)4.10010111
33mitotic G1/S transition checkpoint (GO:0044819)4.02869793
34establishment or maintenance of monopolar cell polarity (GO:0061339)4.02168906
35establishment of monopolar cell polarity (GO:0061162)4.02168906
36telomere maintenance via recombination (GO:0000722)3.97643723
37mitochondrial RNA metabolic process (GO:0000959)3.95258255
38mRNA cleavage (GO:0006379)3.95102361
39G1 DNA damage checkpoint (GO:0044783)3.94877975
40negative regulation of cell cycle arrest (GO:0071157)3.87958258
41negative regulation of JAK-STAT cascade (GO:0046426)3.84645766
42positive regulation of Cdc42 GTPase activity (GO:0043089)3.80511764
43maturation of 5.8S rRNA (GO:0000460)3.80231351
44establishment of protein localization to mitochondrial membrane (GO:0090151)3.75183101
45Golgi transport vesicle coating (GO:0048200)3.74706585
46COPI coating of Golgi vesicle (GO:0048205)3.74706585
47negative regulation of mRNA processing (GO:0050686)3.74146185
48termination of RNA polymerase II transcription (GO:0006369)3.68484366
49regulation of double-strand break repair via homologous recombination (GO:0010569)3.64659717
50spliceosomal tri-snRNP complex assembly (GO:0000244)3.61736878
51negative regulation of RNA splicing (GO:0033119)3.61703373
52dosage compensation (GO:0007549)3.59060458
53pyrimidine nucleotide catabolic process (GO:0006244)3.52914377
54meiotic chromosome segregation (GO:0045132)3.52003277
55double-strand break repair via nonhomologous end joining (GO:0006303)3.48558072
56non-recombinational repair (GO:0000726)3.48558072
57negative regulation of cell size (GO:0045792)3.48182965
58cellular response to zinc ion (GO:0071294)3.48012541
59telomere maintenance via telomere lengthening (GO:0010833)3.47054593
60embryonic placenta development (GO:0001892)3.46194471
61DNA integration (GO:0015074)3.44561730
62protein retention in ER lumen (GO:0006621)3.41111732
63glutamine family amino acid biosynthetic process (GO:0009084)3.40514703
64mitotic recombination (GO:0006312)3.39441407
65positive regulation of protein oligomerization (GO:0032461)3.35676767
66NIK/NF-kappaB signaling (GO:0038061)3.33997724
67regulation of mammary gland epithelial cell proliferation (GO:0033599)3.33200966
68negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.30993798
69positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.29841761
70regulation of sister chromatid cohesion (GO:0007063)3.29816693
71histone H4-K12 acetylation (GO:0043983)3.28066270
72negative regulation of protein oligomerization (GO:0032460)3.27210574
73DNA topological change (GO:0006265)3.25678180
74maternal placenta development (GO:0001893)3.25545377
75kinetochore assembly (GO:0051382)3.25278941
76protein localization to endosome (GO:0036010)3.25214810
77maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.24361726
78GDP-mannose metabolic process (GO:0019673)3.18827204
79nodal signaling pathway (GO:0038092)3.15835274
80positive regulation by host of viral transcription (GO:0043923)3.15167335
81positive regulation of developmental pigmentation (GO:0048087)3.12172234
82mitochondrial DNA replication (GO:0006264)3.10921661
83regulation of protein oligomerization (GO:0032459)3.07930828
84mitotic sister chromatid segregation (GO:0000070)3.06789987
85pseudouridine synthesis (GO:0001522)3.06658443
86negative regulation of viral release from host cell (GO:1902187)3.06308015
87regulation of early endosome to late endosome transport (GO:2000641)3.05056658
88regulation of double-strand break repair (GO:2000779)3.03714931
89negative regulation of mRNA metabolic process (GO:1903312)3.03211759
90ribosome biogenesis (GO:0042254)3.02743758
91apoptotic process involved in morphogenesis (GO:0060561)3.02278414
92trophectodermal cell differentiation (GO:0001829)3.01740285
93semaphorin-plexin signaling pathway (GO:0071526)3.00787496
94modulation by symbiont of host cellular process (GO:0044068)2.99857879
95DNA replication initiation (GO:0006270)2.99411698
96response to peptidoglycan (GO:0032494)2.99238444
97regulation of DNA damage checkpoint (GO:2000001)2.98607776
98focal adhesion assembly (GO:0048041)2.97388594
99cell-substrate adherens junction assembly (GO:0007045)2.97388594
100modulation by virus of host process (GO:0019054)2.96554547
101desmosome organization (GO:0002934)2.96468887
102adherens junction assembly (GO:0034333)2.95880170
103negative regulation of fatty acid biosynthetic process (GO:0045717)2.95319573
104positive regulation of DNA repair (GO:0045739)2.94552913
105mitotic nuclear envelope reassembly (GO:0007084)2.94486456
106nuclear envelope reassembly (GO:0031468)2.94486456
107positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93996444
108positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93996444
109positive regulation of mitotic sister chromatid separation (GO:1901970)2.93996444
110regulation of RNA export from nucleus (GO:0046831)2.91952783
111anatomical structure regression (GO:0060033)2.90747475
112mRNA export from nucleus (GO:0006406)2.89101087
113DNA ligation (GO:0006266)2.87970979
114positive regulation of chromosome segregation (GO:0051984)2.86983128
115DNA double-strand break processing (GO:0000729)2.85605406
116mitotic nuclear envelope disassembly (GO:0007077)2.84151888
117regulation of type I interferon-mediated signaling pathway (GO:0060338)2.84040976
118mitotic chromosome condensation (GO:0007076)2.83604545
119negative regulation of Ras GTPase activity (GO:0034261)2.83569761
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81529987
121resolution of meiotic recombination intermediates (GO:0000712)2.79271550
122cellular response to ATP (GO:0071318)2.78717258
123kinetochore organization (GO:0051383)2.76654255
124pentose-phosphate shunt (GO:0006098)2.76049520
125DNA demethylation (GO:0080111)2.75982228
126translational initiation (GO:0006413)2.75271918
127embryonic camera-type eye development (GO:0031076)2.74979007
128RNA export from nucleus (GO:0006405)2.74808704
129activation of MAPKKK activity (GO:0000185)2.71389938
130urea cycle (GO:0000050)2.70446695
131cell-substrate junction assembly (GO:0007044)2.70321149
132regulation of chromatin binding (GO:0035561)2.68371034
133regulation of glucose import in response to insulin stimulus (GO:2001273)2.68204349
134pinocytosis (GO:0006907)2.67547590
135hemidesmosome assembly (GO:0031581)2.67310995
136snRNA metabolic process (GO:0016073)2.66295300
1373-UTR-mediated mRNA stabilization (GO:0070935)2.63190852
138positive regulation of histone deacetylation (GO:0031065)2.63085815
139regulation of histone H3-K27 methylation (GO:0061085)2.61383125
140activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60785088
141glucose 6-phosphate metabolic process (GO:0051156)2.60046961
142apoptotic process involved in development (GO:1902742)2.58463323
143response to muramyl dipeptide (GO:0032495)2.57589637
144regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57332909
145positive regulation of nuclease activity (GO:0032075)2.57302065
146planar cell polarity pathway involved in neural tube closure (GO:0090179)2.56470416
147basement membrane organization (GO:0071711)2.55555326
148DNA unwinding involved in DNA replication (GO:0006268)2.55524674
149cellular response to virus (GO:0098586)2.54573595
150positive regulation of keratinocyte differentiation (GO:0045618)2.51090699
151regulation of ARF GTPase activity (GO:0032312)2.49880146
152glucose catabolic process (GO:0006007)2.47798272
153stress fiber assembly (GO:0043149)2.47168431
154antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.45261041
155urea metabolic process (GO:0019627)2.43250979
156antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.42216330
157response to laminar fluid shear stress (GO:0034616)2.42184157
158intracellular estrogen receptor signaling pathway (GO:0030520)2.42046366
159lipopolysaccharide-mediated signaling pathway (GO:0031663)2.40871203
160epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38596074
161RNA stabilization (GO:0043489)2.36332365
162mRNA stabilization (GO:0048255)2.36332365
163negative regulation of fatty acid transport (GO:2000192)2.36022753
164developmental programmed cell death (GO:0010623)2.34746197
165regulation of extracellular matrix disassembly (GO:0010715)2.33408886
166regulation of nuclease activity (GO:0032069)2.33334468
167regulation of superoxide anion generation (GO:0032928)2.32887587
168ribosomal small subunit biogenesis (GO:0042274)2.32344145
169activation of JUN kinase activity (GO:0007257)2.30994367
170cell-cell junction maintenance (GO:0045217)2.30717767
171branching involved in mammary gland duct morphogenesis (GO:0060444)2.29904973
172positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.29765029
173epithelial cell-cell adhesion (GO:0090136)2.29607215
174glycosphingolipid catabolic process (GO:0046479)2.28958939
175signal complex assembly (GO:0007172)2.28403151
176UV protection (GO:0009650)2.28275600
177positive regulation of receptor recycling (GO:0001921)2.28138919
178atrioventricular valve morphogenesis (GO:0003181)2.27533884
179barbed-end actin filament capping (GO:0051016)2.26789590
180regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26111808
181NADPH regeneration (GO:0006740)2.25687134
182thymic T cell selection (GO:0045061)2.25538106
183regulation of fatty acid beta-oxidation (GO:0031998)2.25508549
184cellular protein complex localization (GO:0034629)2.25439930
185regulation of viral release from host cell (GO:1902186)2.24505004
186positive regulation of blood vessel endothelial cell migration (GO:0043536)2.23070474
187cellular response to epidermal growth factor stimulus (GO:0071364)2.22649190
188amyloid precursor protein catabolic process (GO:0042987)2.21765279
189positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21648733
190positive regulation of protein dephosphorylation (GO:0035307)2.21330296

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.55124414
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.44579138
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17382499
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.17371511
5VDR_21846776_ChIP-Seq_THP-1_Human2.58362800
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54227118
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53916395
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52488047
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.44939700
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.42449595
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32599977
12MYC_22102868_ChIP-Seq_BL_Human2.31515063
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.20917653
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20120985
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.17410205
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08730185
17* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.08294690
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07076826
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95846676
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94689965
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.93826879
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83894929
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83894929
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83894929
25KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.80494472
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74648027
27E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72741298
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70407759
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67366799
30POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66769567
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.66431157
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.65992369
33* GABP_19822575_ChIP-Seq_HepG2_Human1.65346408
34P68_20966046_ChIP-Seq_HELA_Human1.63067429
35XRN2_22483619_ChIP-Seq_HELA_Human1.62908398
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62412172
37LXR_22292898_ChIP-Seq_THP-1_Human1.61943384
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61235295
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.61221927
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.58684763
41VDR_24763502_ChIP-Seq_THP-1_Human1.57361918
42DCP1A_22483619_ChIP-Seq_HELA_Human1.57046900
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.56328043
44* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.55450774
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54838260
46* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.54429734
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53165374
48SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.52574332
49CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50611781
50* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50184783
51NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48367598
52KDM2B_26808549_Chip-Seq_K562_Human1.47260220
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47207932
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46146246
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45303977
56GABP_17652178_ChIP-ChIP_JURKAT_Human1.44623323
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44406975
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.43300537
59EST1_17652178_ChIP-ChIP_JURKAT_Human1.42548066
60NANOG_21062744_ChIP-ChIP_HESCs_Human1.42404332
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.42333299
62CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41189583
63* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40785727
64KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40683271
65* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.40381326
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.38748721
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.38660810
68POU5F1_16518401_ChIP-PET_MESCs_Mouse1.37951463
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.37768601
70MAF_26560356_Chip-Seq_TH2_Human1.36856023
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.35156614
72SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.34434228
73TTF2_22483619_ChIP-Seq_HELA_Human1.34066342
74KDM5A_27292631_Chip-Seq_BREAST_Human1.34011979
75SMC4_20622854_ChIP-Seq_HELA_Human1.32212483
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31849690
77NCOR1_26117541_ChIP-Seq_K562_Human1.31431869
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.30603532
79DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.29969475
80ZNF263_19887448_ChIP-Seq_K562_Human1.29880942
81VDR_23849224_ChIP-Seq_CD4+_Human1.29822898
82* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.29065367
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29058177
84TCF3_18692474_ChIP-Seq_MESCs_Mouse1.28823722
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.28420579
86ATF3_27146783_Chip-Seq_COLON_Human1.28107174
87TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27554089
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27189278
89UTX_26944678_Chip-Seq_JUKART_Human1.26799487
90ELF1_20517297_ChIP-Seq_JURKAT_Human1.25909182
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24431225
92SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24429997
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24293169
94CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.23258227
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23053118
96CREB1_26743006_Chip-Seq_LNCaP_Human1.22688636
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22660584
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22476520
99* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.22378743
100KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22224098
101KDM2B_26808549_Chip-Seq_JURKAT_Human1.21605745
102NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.21475823
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20319127
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.19876562
105ELK3_25401928_ChIP-Seq_HUVEC_Human1.19138381
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18437182
107GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18069723
108RACK7_27058665_Chip-Seq_MCF-7_Human1.17652160
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16582525
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16364509
111BCL6_27268052_Chip-Seq_Bcells_Human1.14436160
112ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13205475
113RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.12387061
114KDM2B_26808549_Chip-Seq_DND41_Human1.12049897
115CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11390999
116RUNX1_27514584_Chip-Seq_MCF-7_Human1.11090899
117KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.11020539
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.10851702
119* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09685636
120KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.08566642
121NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08456246
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08043420
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08000621
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06991384
125TFEB_21752829_ChIP-Seq_HELA_Human1.06618278
126* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.06391805
127KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06255369
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.06187334
129SRY_22984422_ChIP-ChIP_TESTIS_Rat1.06050782
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05642654
131* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04965070
132FOXP3_21729870_ChIP-Seq_TREG_Human1.04923880
133CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04776100
134CLOCK_20551151_ChIP-Seq_293T_Human1.04235517
135TP53_22127205_ChIP-Seq_IMR90_Human1.03998499
136TCF7_22412390_ChIP-Seq_EML_Mouse1.03594082
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.02925012
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02553142
139MAF_26560356_Chip-Seq_TH1_Human1.02219998
140ETS1_21867929_ChIP-Seq_TH2_Mouse1.01969469
141CREB1_15753290_ChIP-ChIP_HEK293T_Human1.01639547
142PHF8_20622854_ChIP-Seq_HELA_Human1.01495516
143TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01460205
144* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00763316
145CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00648974
146BCOR_27268052_Chip-Seq_Bcells_Human0.99863412
147PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99605777
148MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.99485316
149E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99424836
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99244449
151SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99208495
152CTCF_21964334_Chip-Seq_Bcells_Human0.99149349
153RARB_24833708_ChIP-Seq_LIVER_Mouse0.99074040
154NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.99069097
155ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98832106
156* RARA_24833708_ChIP-Seq_LIVER_Mouse0.97916578
157* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.97908772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.94837776
2MP0003705_abnormal_hypodermis_morpholog4.16676371
3MP0009278_abnormal_bone_marrow4.04450132
4MP0010094_abnormal_chromosome_stability3.40972484
5MP0005451_abnormal_body_composition3.28154958
6MP0004957_abnormal_blastocyst_morpholog3.05244232
7MP0010234_abnormal_vibrissa_follicle3.03116411
8MP0003693_abnormal_embryo_hatching2.92469214
9MP0010030_abnormal_orbit_morphology2.88159316
10MP0005171_absent_coat_pigmentation2.75212305
11MP0003111_abnormal_nucleus_morphology2.73619078
12MP0001545_abnormal_hematopoietic_system2.66734440
13MP0005397_hematopoietic_system_phenotyp2.66734440
14MP0008260_abnormal_autophagy2.56182161
15MP0004233_abnormal_muscle_weight2.50896693
16MP0001849_ear_inflammation2.49864666
17MP0004185_abnormal_adipocyte_glucose2.40819165
18MP0003077_abnormal_cell_cycle2.34007459
19MP0009840_abnormal_foam_cell2.28205401
20MP0003436_decreased_susceptibility_to2.26657367
21MP0008058_abnormal_DNA_repair2.18385617
22MP0002009_preneoplasia2.16507501
23MP0003303_peritoneal_inflammation2.14850717
24MP0008995_early_reproductive_senescence2.12600410
25MP0003786_premature_aging2.09083189
26MP0000490_abnormal_crypts_of2.07689111
27MP0005174_abnormal_tail_pigmentation2.03562858
28MP0000678_abnormal_parathyroid_gland2.00411577
29MP0002653_abnormal_ependyma_morphology2.00254087
30MP0002877_abnormal_melanocyte_morpholog1.99572832
31MP0005360_urolithiasis1.96701427
32MP0003191_abnormal_cellular_cholesterol1.95822020
33MP0010352_gastrointestinal_tract_polyps1.95682233
34MP0003566_abnormal_cell_adhesion1.89898072
35MP0008932_abnormal_embryonic_tissue1.87370125
36MP0004947_skin_inflammation1.83039231
37MP0002396_abnormal_hematopoietic_system1.79490644
38MP0003890_abnormal_embryonic-extraembry1.78037647
39MP0000858_altered_metastatic_potential1.73211517
40MP0001697_abnormal_embryo_size1.68252796
41MP0008877_abnormal_DNA_methylation1.67435703
42MP0004133_heterotaxia1.67069308
43MP0004858_abnormal_nervous_system1.64522178
44MP0002086_abnormal_extraembryonic_tissu1.63722046
45MP0003119_abnormal_digestive_system1.60816447
46MP0000350_abnormal_cell_proliferation1.60312602
47MP0005075_abnormal_melanosome_morpholog1.56463496
48MP0005666_abnormal_adipose_tissue1.55903362
49MP0002084_abnormal_developmental_patter1.54303594
50MP0001730_embryonic_growth_arrest1.52618633
51MP0003172_abnormal_lysosome_physiology1.51203963
52MP0002085_abnormal_embryonic_tissue1.50728292
53MP0005076_abnormal_cell_differentiation1.50497712
54MP0002019_abnormal_tumor_incidence1.47945112
55MP0004510_myositis1.46855561
56MP0009333_abnormal_splenocyte_physiolog1.46069075
57MP0003453_abnormal_keratinocyte_physiol1.46010065
58MP0006072_abnormal_retinal_apoptosis1.45201164
59MP0001293_anophthalmia1.44936349
60MP0000685_abnormal_immune_system1.43487198
61MP0003763_abnormal_thymus_physiology1.42660763
62MP0003283_abnormal_digestive_organ1.42054820
63MP0003718_maternal_effect1.41442882
64MP0000537_abnormal_urethra_morphology1.40146691
65MP0005380_embryogenesis_phenotype1.39397077
66MP0001672_abnormal_embryogenesis/_devel1.39397077
67MP0000003_abnormal_adipose_tissue1.36480139
68MP0003567_abnormal_fetal_cardiomyocyte1.36387645
69MP0005375_adipose_tissue_phenotype1.35448785
70MP0002060_abnormal_skin_morphology1.34110271
71MP0003300_gastrointestinal_ulcer1.33121885
72MP0002089_abnormal_postnatal_growth/wei1.31514684
73MP0004197_abnormal_fetal_growth/weight/1.31212504
74MP0002249_abnormal_larynx_morphology1.31120061
75MP0003091_abnormal_cell_migration1.30602401
76MP0002080_prenatal_lethality1.28467475
77MP0005409_darkened_coat_color1.27954259
78MP0001216_abnormal_epidermal_layer1.26724176
79MP0001348_abnormal_lacrimal_gland1.20637563
80MP0002269_muscular_atrophy1.18395840
81MP0005058_abnormal_lysosome_morphology1.17991927
82MP0000313_abnormal_cell_death1.17870998
83MP0000371_diluted_coat_color1.16906130
84MP0000015_abnormal_ear_pigmentation1.15877535
85MP0002282_abnormal_trachea_morphology1.15460237
86MP0003656_abnormal_erythrocyte_physiolo1.15325590
87MP0010307_abnormal_tumor_latency1.15263383
88MP0000689_abnormal_spleen_morphology1.15036283
89MP0005025_abnormal_response_to1.13626640
90MP0001853_heart_inflammation1.12488956
91MP0008438_abnormal_cutaneous_collagen1.11493211
92MP0002254_reproductive_system_inflammat1.11060427
93MP0008007_abnormal_cellular_replicative1.10900049
94MP0003984_embryonic_growth_retardation1.10852775
95MP0002405_respiratory_system_inflammati1.10219498
96MP0009931_abnormal_skin_appearance1.09453961
97MP0000733_abnormal_muscle_development1.07649168
98MP0002088_abnormal_embryonic_growth/wei1.05378692
99MP0004264_abnormal_extraembryonic_tissu1.03445103
100MP0004808_abnormal_hematopoietic_stem1.02099141
101MP0000470_abnormal_stomach_morphology1.01172125
102MP0002398_abnormal_bone_marrow1.00607489
103MP0000579_abnormal_nail_morphology0.99630186
104MP0002419_abnormal_innate_immunity0.98465647
105MP0002722_abnormal_immune_system0.95780798
106MP0002111_abnormal_tail_morphology0.95674110
107MP0000703_abnormal_thymus_morphology0.95462725
108MP0005621_abnormal_cell_physiology0.95095073
109MP0005000_abnormal_immune_tolerance0.94567463
110MP0003183_abnormal_peptide_metabolism0.94187950
111MP0000639_abnormal_adrenal_gland0.93965393
112MP0004381_abnormal_hair_follicle0.91836221
113MP0001533_abnormal_skeleton_physiology0.90172113
114MP0005257_abnormal_intraocular_pressure0.89277129
115MP0002932_abnormal_joint_morphology0.88797814
116MP0005266_abnormal_metabolism0.86879723
117MP0002075_abnormal_coat/hair_pigmentati0.86751223
118MP0002098_abnormal_vibrissa_morphology0.86541439
119MP0000467_abnormal_esophagus_morphology0.86517635
120MP0001790_abnormal_immune_system0.85913786
121MP0005387_immune_system_phenotype0.85913786
122MP0002166_altered_tumor_susceptibility0.84198779
123MP0005023_abnormal_wound_healing0.83390698
124MP0001835_abnormal_antigen_presentation0.83197658
125MP0001819_abnormal_immune_cell0.82498768
126MP0001145_abnormal_male_reproductive0.82244522
127MP0005464_abnormal_platelet_physiology0.81937752
128MP0000477_abnormal_intestine_morphology0.81637862
129MP0002420_abnormal_adaptive_immunity0.80859620
130MP0002998_abnormal_bone_remodeling0.80843058
131MP0009379_abnormal_foot_pigmentation0.80776872
132MP0002723_abnormal_immune_serum0.80161434
133MP0002452_abnormal_antigen_presenting0.79139749
134MP0002148_abnormal_hypersensitivity_rea0.78618055
135MP0003448_altered_tumor_morphology0.77494367
136MP0001873_stomach_inflammation0.77448119
137MP0003828_pulmonary_edema0.76949170
138MP0003806_abnormal_nucleotide_metabolis0.75715773
139MP0000462_abnormal_digestive_system0.75338968
140MP0001800_abnormal_humoral_immune0.74560157
141MP0009115_abnormal_fat_cell0.74065306
142MP0003699_abnormal_female_reproductive0.73545390
143MP0003279_aneurysm0.73006946
144MP0002429_abnormal_blood_cell0.72594405
145MP0002132_abnormal_respiratory_system0.71471112
146MP0001845_abnormal_inflammatory_respons0.70765688
147MP0006082_CNS_inflammation0.70044170
148MP0005501_abnormal_skin_physiology0.69946689
149MP0002970_abnormal_white_adipose0.69542999
150MP0001186_pigmentation_phenotype0.68657989
151MP0001340_abnormal_eyelid_morphology0.68363571
152MP0010155_abnormal_intestine_physiology0.68327601
153MP0002114_abnormal_axial_skeleton0.68041910
154MP0000653_abnormal_sex_gland0.67976486
155MP0002210_abnormal_sex_determination0.67652936
156MP0001119_abnormal_female_reproductive0.67081999
157MP0002006_tumorigenesis0.65583130
158MP0002796_impaired_skin_barrier0.65515375
159MP0001915_intracranial_hemorrhage0.64641671
160MP0000716_abnormal_immune_system0.62915737

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.15664002
2Rib fusion (HP:0000902)5.12927404
3Poikiloderma (HP:0001029)4.83294471
4Annular pancreas (HP:0001734)4.73849497
5Facial hemangioma (HP:0000329)4.66201665
6Concave nail (HP:0001598)4.29221707
7Rectovaginal fistula (HP:0000143)4.27482970
8Rectal fistula (HP:0100590)4.27482970
9Increased IgM level (HP:0003496)4.21427401
10Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.11524967
11Tongue fasciculations (HP:0001308)3.97894946
12Intestinal fistula (HP:0100819)3.88485252
13Male infertility (HP:0003251)3.88127355
14Vaginal fistula (HP:0004320)3.84756919
15Ulnar bowing (HP:0003031)3.75774741
16Muscle fibrillation (HP:0010546)3.60241459
17Alopecia of scalp (HP:0002293)3.56462805
18Turricephaly (HP:0000262)3.50178331
19Basal cell carcinoma (HP:0002671)3.46716673
20Absent thumb (HP:0009777)3.38407544
21Squamous cell carcinoma (HP:0002860)3.32481934
22Selective tooth agenesis (HP:0001592)3.32148898
23Patellar aplasia (HP:0006443)3.22131253
24Aplasia/hypoplasia of the humerus (HP:0006507)3.21828322
25Short humerus (HP:0005792)3.20398774
26Absent radius (HP:0003974)3.19981448
27Hypochromic microcytic anemia (HP:0004840)3.19565208
28Vertebral hypoplasia (HP:0008417)3.16359296
29Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.16359296
30Abnormal hemoglobin (HP:0011902)3.15451609
31Orthostatic hypotension (HP:0001278)3.13375321
32Broad face (HP:0000283)3.11682009
33Thin bony cortex (HP:0002753)3.11071430
34Hyperacusis (HP:0010780)3.07871774
35Absent forearm bone (HP:0003953)3.02346199
36Aplasia involving forearm bones (HP:0009822)3.02346199
37Albinism (HP:0001022)2.99207636
38Abnormality of male internal genitalia (HP:0000022)2.95211922
39Aplasia/Hypoplasia of the patella (HP:0006498)2.92399989
40J-shaped sella turcica (HP:0002680)2.89433648
41Congenital hip dislocation (HP:0001374)2.85153791
42Intestinal atresia (HP:0011100)2.84880104
43Broad alveolar ridges (HP:0000187)2.83782505
44Distal lower limb amyotrophy (HP:0008944)2.81350042
45Mucopolysacchariduria (HP:0008155)2.81319684
46Urinary glycosaminoglycan excretion (HP:0003541)2.81319684
47Premature graying of hair (HP:0002216)2.80881706
48Cervical subluxation (HP:0003308)2.80152419
49Flat acetabular roof (HP:0003180)2.80128463
50Joint stiffness (HP:0001387)2.76903335
51Short chin (HP:0000331)2.68601899
52Acute lymphatic leukemia (HP:0006721)2.67441915
53Premature skin wrinkling (HP:0100678)2.66742187
54Dysautonomia (HP:0002459)2.66705913
55Achilles tendon contracture (HP:0001771)2.65418071
56Malnutrition (HP:0004395)2.62857989
57Distal upper limb amyotrophy (HP:0007149)2.62456499
58Upper limb amyotrophy (HP:0009129)2.62456499
59Stridor (HP:0010307)2.61549848
60Diaphragmatic weakness (HP:0009113)2.60141228
61Dysostosis multiplex (HP:0000943)2.57098900
62Large for gestational age (HP:0001520)2.54577580
63Abnormality of polysaccharide metabolism (HP:0011012)2.54034347
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.54034347
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.54034347
66Coronal craniosynostosis (HP:0004440)2.52508327
67Muscle fiber atrophy (HP:0100295)2.52042165
68Polycythemia (HP:0001901)2.48041805
69Anteriorly placed anus (HP:0001545)2.44377347
70Abnormality of the aortic arch (HP:0012303)2.44091796
71Distal lower limb muscle weakness (HP:0009053)2.43185006
72Obstructive sleep apnea (HP:0002870)2.42548922
73Breast hypoplasia (HP:0003187)2.39177419
74Increased connective tissue (HP:0009025)2.38843731
75Hypochromic anemia (HP:0001931)2.38606386
76Abnormality of the Achilles tendon (HP:0005109)2.36758874
77Abnormality of cells of the erythroid lineage (HP:0012130)2.33369590
78Type 2 muscle fiber atrophy (HP:0003554)2.33274676
79Pancreatic islet-cell hyperplasia (HP:0004510)2.33263151
80Premature rupture of membranes (HP:0001788)2.32345302
81Capillary hemangiomas (HP:0005306)2.32084695
82Abnormal number of erythroid precursors (HP:0012131)2.31496192
83Bowed forearm bones (HP:0003956)2.30542811
84Bowing of the arm (HP:0006488)2.30542811
85Volvulus (HP:0002580)2.28740777
86Cerebral aneurysm (HP:0004944)2.27717023
87Disproportionate tall stature (HP:0001519)2.27535672
88Growth hormone excess (HP:0000845)2.26621894
89Long palpebral fissure (HP:0000637)2.25943842
90Metaphyseal cupping (HP:0003021)2.24714195
91IgA deficiency (HP:0002720)2.24178008
92Abnormality of the thoracic spine (HP:0100711)2.23918491
93Hemorrhage of the eye (HP:0011885)2.23222302
94Axonal loss (HP:0003447)2.22411786
95Birth length less than 3rd percentile (HP:0003561)2.22136413
96Vertebral compression fractures (HP:0002953)2.20190539
97Hypotrichosis (HP:0001006)2.17718983
98Bifid uvula (HP:0000193)2.17022362
99Spinal muscular atrophy (HP:0007269)2.16779896
100Hypotelorism (HP:0000601)2.16541650
101Hypoplasia of the radius (HP:0002984)2.16184010
102Eczematoid dermatitis (HP:0000976)2.15850121
103Vertebral fusion (HP:0002948)2.14765407
104Exertional dyspnea (HP:0002875)2.14531510
105Cellulitis (HP:0100658)2.11723422
106Abnormality of the distal phalanges of the toes (HP:0010182)2.09181405
107Abnormality of the ileum (HP:0001549)2.07916045
108Abdominal distention (HP:0003270)2.07782511
109Gastrointestinal inflammation (HP:0004386)2.06947865
110Fragile skin (HP:0001030)2.05180005
111Choanal stenosis (HP:0000452)2.04541462
112Hypertensive crisis (HP:0100735)2.04351686
113Premature ovarian failure (HP:0008209)2.02651822
114Trismus (HP:0000211)2.01972600
115Nuclear cataract (HP:0100018)1.98655838
116Increased cerebral lipofuscin (HP:0011813)1.98511654
117Neoplasm of the oral cavity (HP:0100649)1.98184407
118Hypokinesia (HP:0002375)1.98139319
119Alacrima (HP:0000522)1.98085378
120Flattened epiphyses (HP:0003071)1.97653521
121Astrocytoma (HP:0009592)1.97018649
122Abnormality of the astrocytes (HP:0100707)1.97018649
123Redundant skin (HP:0001582)1.96254967
124Abnormal number of incisors (HP:0011064)1.95845834
125Short 5th finger (HP:0009237)1.95655593
126Hamartoma (HP:0010566)1.94389096
127Biconcave vertebral bodies (HP:0004586)1.93680301
128Abnormality of T cell physiology (HP:0011840)1.92813225
129Increased serum ferritin (HP:0003281)1.92542026
130Loss of speech (HP:0002371)1.91978563
131Thoracic kyphosis (HP:0002942)1.91240867
132Colitis (HP:0002583)1.90702723
133Deep venous thrombosis (HP:0002625)1.90218368
134Ragged-red muscle fibers (HP:0003200)1.89999887
135Short thumb (HP:0009778)1.89618453
136Abnormality of the labia minora (HP:0012880)1.88884668
137Polygenic inheritance (HP:0010982)1.88321673
138Aplasia of the musculature (HP:0100854)1.87851048
139Easy fatigability (HP:0003388)1.87569802
140Rough bone trabeculation (HP:0100670)1.87146681
141Progressive external ophthalmoplegia (HP:0000590)1.86155987
142Bone pain (HP:0002653)1.85754274
143Lower limb hyperreflexia (HP:0002395)1.85676107
144Ependymoma (HP:0002888)1.85255717
145Hyperparathyroidism (HP:0000843)1.84536809
146Short nail (HP:0001799)1.84270790
147Protrusio acetabuli (HP:0003179)1.84264749
148Generalized amyotrophy (HP:0003700)1.83878763
149Cheilitis (HP:0100825)1.83669005
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.83601241
151Seborrheic dermatitis (HP:0001051)1.82604742
152Broad distal phalanx of finger (HP:0009836)1.81039316
153Reticulocytosis (HP:0001923)1.80549176
154Abnormal hair laboratory examination (HP:0003328)1.80443985
155Gastrointestinal dysmotility (HP:0002579)1.79036783
156Hypertriglyceridemia (HP:0002155)1.78597958
157Difficulty climbing stairs (HP:0003551)1.78257712
158Abnormal vertebral ossification (HP:0100569)1.77511342
159Myopathic facies (HP:0002058)1.77224019
160Elbow flexion contracture (HP:0002987)1.75812363
161Asymmetry of the thorax (HP:0001555)1.75108281
162Spinal cord compression (HP:0002176)1.75085090
163Flared metaphyses (HP:0003015)1.73682109
164Insomnia (HP:0100785)1.72470357
165Neuronal loss in central nervous system (HP:0002529)1.71778571
166Abnormal gallbladder physiology (HP:0012438)1.71185329
167Cholecystitis (HP:0001082)1.71185329
168Elevated alkaline phosphatase (HP:0003155)1.70692609
169Abnormality of macrophages (HP:0004311)1.70554618
170Inflammation of the large intestine (HP:0002037)1.69556494
171Nail dystrophy (HP:0008404)1.69378929
172Blue sclerae (HP:0000592)1.69132199
173Interstitial pulmonary disease (HP:0006530)1.68288619
174Bulbar palsy (HP:0001283)1.67682127
175Hand muscle atrophy (HP:0009130)1.67365558
176Abnormal trabecular bone morphology (HP:0100671)1.66914071
177Lower limb amyotrophy (HP:0007210)1.66911075
178Progressive muscle weakness (HP:0003323)1.66884800
179Abnormality of alkaline phosphatase activity (HP:0004379)1.66824124
180Pili torti (HP:0003777)1.66239407
181Mildly elevated creatine phosphokinase (HP:0008180)1.65868090
182Recurrent abscess formation (HP:0002722)1.65544063
183Recurrent bacterial skin infections (HP:0005406)1.64620338
184Atrophic scars (HP:0001075)1.63906251
185Mitral regurgitation (HP:0001653)1.63884142
186Emphysema (HP:0002097)1.63736237
187Abnormal enzyme/coenzyme activity (HP:0012379)1.62487777

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.13453929
2MAPK154.70332173
3MAP3K64.41275351
4DDR23.94358769
5SIK13.56606033
6SMG13.49445804
7MAP3K113.44765282
8IRAK33.21528653
9PRPF4B2.88805564
10MATK2.80782480
11PINK12.77813458
12MST1R2.54696969
13PIM22.54484862
14TYRO32.48817917
15DAPK12.43102173
16FGR2.25918515
17CDK72.07367130
18PRKD22.03366530
19MAP2K31.95253004
20CSK1.86392352
21UHMK11.79576192
22DYRK1B1.76811867
23BMX1.75226464
24YES11.65424431
25PDGFRA1.62685936
26RIPK11.54254568
27PIM11.51654387
28MAP3K101.50249889
29BUB11.44041134
30DYRK31.43706579
31FGFR41.42637896
32TESK11.42497612
33MAP3K131.39207246
34WEE11.37352191
35SIK31.33261886
36CDC71.32102134
37CDK61.31325107
38TTN1.26328824
39LATS21.24189157
40PTK61.22257249
41NEK21.22165262
42MAPK111.21729297
43IRAK41.21083770
44PLK11.19130003
45TRIB31.17648995
46CHEK21.17064080
47RIPK41.14921746
48TBK11.14717655
49MAP3K31.13933374
50RPS6KC11.13758019
51RPS6KL11.13758019
52MAP4K11.11763339
53RAF11.06298208
54MET1.05949214
55TRPM71.05658205
56MAP3K141.03838776
57RPS6KA61.03043747
58RPS6KB21.01278656
59PTK21.00872224
60AKT31.00322650
61SIK20.97339142
62IRAK20.96181917
63EPHB10.90638739
64EEF2K0.87592916
65ATR0.86973634
66NME20.86714902
67HIPK20.86259196
68MAP3K10.85713155
69TYK20.85145399
70PDPK10.81814177
71MARK20.80819069
72FLT30.79928994
73TAOK20.78673809
74PRKD30.78064817
75MOS0.77025551
76ARAF0.75886818
77GSK3A0.74764989
78STK100.74090531
79CDC42BPA0.69095244
80CDK40.69092607
81RPS6KA20.68693407
82TNK20.68508228
83MAPKAPK30.67622698
84TAOK10.67606247
85MTOR0.67169181
86CDK120.67065652
87LMTK20.66391198
88MAP2K60.65841595
89BRAF0.64852727
90RPS6KA10.62987814
91PRKG20.62578260
92ILK0.62410289
93AURKA0.61898593
94TESK20.61656391
95MAP2K20.61327069
96KSR20.61065724
97AURKB0.60703233
98TTK0.60608267
99MAP3K90.60226207
100NEK10.58945054
101CDK20.58579031
102JAK30.57119898
103MAP3K80.55020450
104SCYL20.53644447
105LYN0.52810154
106ACVR1B0.52386527
107CHEK10.51377207
108BCKDK0.51152660
109PAK40.49430585
110EPHA20.48505063
111PRKAA10.48414029
112CSNK2A10.48033489
113GRK60.47528249
114PHKG10.44119843
115PHKG20.44119843
116VRK20.43347132
117MAPKAPK20.42487797
118MAPK120.42286010
119DYRK20.42072420
120PDK10.41577339
121CSNK2A20.38952509
122CDK80.38230853
123NTRK10.37996920
124PKN20.37940387
125NME10.36124904
126MAPK30.36051820
127ATM0.35562045
128IKBKB0.34914530
129MAPK40.34873814
130CSF1R0.34497254
131BRSK20.34312206
132ERN10.34199439
133KDR0.34121915
134BTK0.33240948
135CHUK0.32561085
136MAPK10.31917262
137PAK10.31144785
138ZAP700.30304509
139EGFR0.30301711
140ALK0.29299955
141BLK0.29232319
142RPS6KA40.28756454
143LCK0.28594834
144CSNK1G10.27888394
145LRRK20.27725893
146RPS6KB10.27363653
147STK30.25496090
148CDK10.25227988
149PAK20.25206355
150MAPK140.22421391
151PRKCI0.22030036

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.10388780
2DNA replication_Homo sapiens_hsa030305.03321319
3Base excision repair_Homo sapiens_hsa034104.88083842
4Other glycan degradation_Homo sapiens_hsa005113.73418550
5Fatty acid biosynthesis_Homo sapiens_hsa000613.38622965
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84501894
7Nucleotide excision repair_Homo sapiens_hsa034202.75148617
8Spliceosome_Homo sapiens_hsa030402.71707106
9RNA transport_Homo sapiens_hsa030132.45005479
10Ribosome_Homo sapiens_hsa030102.41461182
11Homologous recombination_Homo sapiens_hsa034402.37255209
12Sulfur relay system_Homo sapiens_hsa041222.10930659
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00864842
14Cell cycle_Homo sapiens_hsa041101.98478326
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.98318283
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.97794922
17mRNA surveillance pathway_Homo sapiens_hsa030151.89641076
18Fanconi anemia pathway_Homo sapiens_hsa034601.86863654
19Folate biosynthesis_Homo sapiens_hsa007901.76476000
20p53 signaling pathway_Homo sapiens_hsa041151.70897700
21Non-small cell lung cancer_Homo sapiens_hsa052231.64089598
22Notch signaling pathway_Homo sapiens_hsa043301.62533618
23Biosynthesis of amino acids_Homo sapiens_hsa012301.53527082
24RNA polymerase_Homo sapiens_hsa030201.53348681
25Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.49467896
26mTOR signaling pathway_Homo sapiens_hsa041501.45003740
27One carbon pool by folate_Homo sapiens_hsa006701.44522357
28Primary immunodeficiency_Homo sapiens_hsa053401.37466829
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35534641
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.34427017
31Pyrimidine metabolism_Homo sapiens_hsa002401.34249216
32Circadian rhythm_Homo sapiens_hsa047101.29975250
33Arginine and proline metabolism_Homo sapiens_hsa003301.29744161
34Osteoclast differentiation_Homo sapiens_hsa043801.25992575
35Hepatitis C_Homo sapiens_hsa051601.25896607
36Proteasome_Homo sapiens_hsa030501.25809797
37Prion diseases_Homo sapiens_hsa050201.19633827
38RNA degradation_Homo sapiens_hsa030181.17183832
39Hippo signaling pathway_Homo sapiens_hsa043901.11657704
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11456148
41TNF signaling pathway_Homo sapiens_hsa046681.09437877
42Influenza A_Homo sapiens_hsa051641.08820853
43Bladder cancer_Homo sapiens_hsa052191.08467690
44Hedgehog signaling pathway_Homo sapiens_hsa043401.08357402
45Leishmaniasis_Homo sapiens_hsa051401.07899206
46RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.07752580
47Shigellosis_Homo sapiens_hsa051311.06549533
48Lysosome_Homo sapiens_hsa041421.04113613
49Toxoplasmosis_Homo sapiens_hsa051451.03496549
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.03096278
51NF-kappa B signaling pathway_Homo sapiens_hsa040641.02658918
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97719702
53Glioma_Homo sapiens_hsa052140.95546389
54AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93857958
55Oocyte meiosis_Homo sapiens_hsa041140.91559183
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.90139597
57Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89980660
58TGF-beta signaling pathway_Homo sapiens_hsa043500.89568181
59Fructose and mannose metabolism_Homo sapiens_hsa000510.88153143
60Leukocyte transendothelial migration_Homo sapiens_hsa046700.87189785
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86427740
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85031647
63ErbB signaling pathway_Homo sapiens_hsa040120.84716504
64Colorectal cancer_Homo sapiens_hsa052100.84190240
65Basal transcription factors_Homo sapiens_hsa030220.83970411
66Adherens junction_Homo sapiens_hsa045200.83246337
67Vitamin B6 metabolism_Homo sapiens_hsa007500.82298441
68Salmonella infection_Homo sapiens_hsa051320.81899160
69Acute myeloid leukemia_Homo sapiens_hsa052210.81185653
70Renal cell carcinoma_Homo sapiens_hsa052110.81070982
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80948124
72VEGF signaling pathway_Homo sapiens_hsa043700.80359410
73GnRH signaling pathway_Homo sapiens_hsa049120.78778673
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.77419229
75Insulin resistance_Homo sapiens_hsa049310.76787709
76T cell receptor signaling pathway_Homo sapiens_hsa046600.76499181
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76170568
78Thyroid cancer_Homo sapiens_hsa052160.76118380
79Prolactin signaling pathway_Homo sapiens_hsa049170.74248436
80Lysine degradation_Homo sapiens_hsa003100.72864406
81Chronic myeloid leukemia_Homo sapiens_hsa052200.72617170
82Herpes simplex infection_Homo sapiens_hsa051680.72189606
83Tuberculosis_Homo sapiens_hsa051520.71624088
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.70861331
85Prostate cancer_Homo sapiens_hsa052150.70537248
86Proteoglycans in cancer_Homo sapiens_hsa052050.69285868
87Epstein-Barr virus infection_Homo sapiens_hsa051690.67880471
88Arginine biosynthesis_Homo sapiens_hsa002200.66331618
89Cysteine and methionine metabolism_Homo sapiens_hsa002700.65991501
90Amoebiasis_Homo sapiens_hsa051460.64885197
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64464984
92Fatty acid metabolism_Homo sapiens_hsa012120.64140481
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63944156
94Legionellosis_Homo sapiens_hsa051340.63828553
95Viral carcinogenesis_Homo sapiens_hsa052030.63643419
96Endocytosis_Homo sapiens_hsa041440.63324794
97Pertussis_Homo sapiens_hsa051330.63240924
98Inositol phosphate metabolism_Homo sapiens_hsa005620.63079265
99Focal adhesion_Homo sapiens_hsa045100.62962026
100Galactose metabolism_Homo sapiens_hsa000520.62817991
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.62584976
102Wnt signaling pathway_Homo sapiens_hsa043100.62554270
103Estrogen signaling pathway_Homo sapiens_hsa049150.62517337
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62353173
105Renin-angiotensin system_Homo sapiens_hsa046140.62108474
106Sphingolipid signaling pathway_Homo sapiens_hsa040710.61320755
107Basal cell carcinoma_Homo sapiens_hsa052170.60249993
108Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59901884
109MicroRNAs in cancer_Homo sapiens_hsa052060.59702896
110Small cell lung cancer_Homo sapiens_hsa052220.59242436
111Non-homologous end-joining_Homo sapiens_hsa034500.58303906
112Vibrio cholerae infection_Homo sapiens_hsa051100.55082811
113Vitamin digestion and absorption_Homo sapiens_hsa049770.54139400
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.54097597
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53560848
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53180201
117Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52929120
118Selenocompound metabolism_Homo sapiens_hsa004500.50748773
119HTLV-I infection_Homo sapiens_hsa051660.50724524
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50210628
121Carbon metabolism_Homo sapiens_hsa012000.48348984
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47342138
123N-Glycan biosynthesis_Homo sapiens_hsa005100.46667617
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45293176
125Viral myocarditis_Homo sapiens_hsa054160.44304321
126B cell receptor signaling pathway_Homo sapiens_hsa046620.44126957
127Cyanoamino acid metabolism_Homo sapiens_hsa004600.40938112
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.39993318
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.39954662
130Hepatitis B_Homo sapiens_hsa051610.38912574
131Pentose phosphate pathway_Homo sapiens_hsa000300.38303200
132Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38112601
133Glutathione metabolism_Homo sapiens_hsa004800.37926394
134Pancreatic cancer_Homo sapiens_hsa052120.35240342
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33580132
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32983133
137AMPK signaling pathway_Homo sapiens_hsa041520.31265833
138Measles_Homo sapiens_hsa051620.29958514
139Purine metabolism_Homo sapiens_hsa002300.29577879
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29282555
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28834835
142Choline metabolism in cancer_Homo sapiens_hsa052310.28229114
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27438834
144Insulin signaling pathway_Homo sapiens_hsa049100.27346638
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26206611
146Apoptosis_Homo sapiens_hsa042100.26006575
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.25010997
148Antigen processing and presentation_Homo sapiens_hsa046120.22238644
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.17203461
150HIF-1 signaling pathway_Homo sapiens_hsa040660.16421590
151Pathways in cancer_Homo sapiens_hsa052000.15590734
152Endometrial cancer_Homo sapiens_hsa052130.15480799
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14559127

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