FBXL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.99410433
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.99410433
3antigen processing and presentation of endogenous antigen (GO:0019883)5.21728228
4positive regulation of gamma-delta T cell activation (GO:0046645)5.06196531
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.34152491
6positive regulation of defense response to virus by host (GO:0002230)4.26502821
7Arp2/3 complex-mediated actin nucleation (GO:0034314)4.25958981
8ribosomal small subunit assembly (GO:0000028)4.24102945
9positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.20877271
10adaptation of signaling pathway (GO:0023058)3.93232144
11negative regulation of phagocytosis (GO:0050765)3.87746860
12regulation of gamma-delta T cell differentiation (GO:0045586)3.80539788
13positive regulation of B cell differentiation (GO:0045579)3.80002900
14viral transcription (GO:0019083)3.75047565
15mannose metabolic process (GO:0006013)3.65394227
16preassembly of GPI anchor in ER membrane (GO:0016254)3.64354640
17regulation of gamma-delta T cell activation (GO:0046643)3.60793797
18translational termination (GO:0006415)3.57938915
19mannosylation (GO:0097502)3.54310722
20cornea development in camera-type eye (GO:0061303)3.50993591
21negative regulation of telomere maintenance (GO:0032205)3.50242143
22regulation of B cell receptor signaling pathway (GO:0050855)3.42847171
23behavioral response to nicotine (GO:0035095)3.41616819
24regulation of B cell differentiation (GO:0045577)3.41543740
25leukocyte aggregation (GO:0070486)3.35243942
26SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.34238530
27interferon-gamma production (GO:0032609)3.32923477
28cotranslational protein targeting to membrane (GO:0006613)3.24755564
29protein targeting to ER (GO:0045047)3.24242665
30positive regulation of protein kinase C signaling (GO:0090037)3.23690355
31antigen processing and presentation via MHC class Ib (GO:0002475)3.22309562
32translational elongation (GO:0006414)3.19850775
33regulation of defense response to virus by host (GO:0050691)3.17200887
34actin nucleation (GO:0045010)3.16685532
35positive regulation of prostaglandin secretion (GO:0032308)3.14829113
36protein localization to endoplasmic reticulum (GO:0070972)3.11637578
37establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07062091
38indolalkylamine metabolic process (GO:0006586)3.06866702
39tolerance induction (GO:0002507)3.05872314
40T cell homeostasis (GO:0043029)3.02959024
41mast cell activation (GO:0045576)3.02859447
42phosphatidylglycerol biosynthetic process (GO:0006655)3.02365641
43NIK/NF-kappaB signaling (GO:0038061)3.02077977
44CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.01932599
45regulation of chronic inflammatory response (GO:0002676)3.01745017
46immunoglobulin mediated immune response (GO:0016064)3.00378024
47regulation of protein heterodimerization activity (GO:0043497)2.98092156
48negative T cell selection (GO:0043383)2.96697327
49negative thymic T cell selection (GO:0045060)2.95655877
50response to pheromone (GO:0019236)2.94866543
51regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.94494381
52metallo-sulfur cluster assembly (GO:0031163)2.93861692
53iron-sulfur cluster assembly (GO:0016226)2.93861692
54C-terminal protein lipidation (GO:0006501)2.92893810
55positive regulation of icosanoid secretion (GO:0032305)2.92241218
56positive thymic T cell selection (GO:0045059)2.91159214
57ribosomal small subunit biogenesis (GO:0042274)2.90798508
58telomere maintenance via semi-conservative replication (GO:0032201)2.90003838
59GPI anchor metabolic process (GO:0006505)2.88591894
60positive regulation of fatty acid transport (GO:2000193)2.87775066
61B cell receptor signaling pathway (GO:0050853)2.87620060
62viral life cycle (GO:0019058)2.86563831
63response to type I interferon (GO:0034340)2.85857868
64positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84139855
65kynurenine metabolic process (GO:0070189)2.83731599
66GPI anchor biosynthetic process (GO:0006506)2.83328217
67positive regulation of triglyceride biosynthetic process (GO:0010867)2.83306791
68T cell migration (GO:0072678)2.83212882
69tRNA modification (GO:0006400)2.82030571
70cellular response to ATP (GO:0071318)2.81841262
71negative regulation of erythrocyte differentiation (GO:0045647)2.81011590
72indole-containing compound catabolic process (GO:0042436)2.80613446
73indolalkylamine catabolic process (GO:0046218)2.80613446
74tryptophan catabolic process (GO:0006569)2.80613446
75type I interferon signaling pathway (GO:0060337)2.80277735
76cellular response to type I interferon (GO:0071357)2.80277735
77sulfate transmembrane transport (GO:1902358)2.79429327
78positive regulation of lamellipodium assembly (GO:0010592)2.78612191
79tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.78222313
80RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.78222313
81regulation of interleukin-12 biosynthetic process (GO:0045075)2.77724157
82purine deoxyribonucleotide catabolic process (GO:0009155)2.75323882
83regulation of type I interferon-mediated signaling pathway (GO:0060338)2.74286027
84DNA strand elongation involved in DNA replication (GO:0006271)2.73249216
85response to interleukin-15 (GO:0070672)2.73166096
86piRNA metabolic process (GO:0034587)2.72921925
87cellular response to interferon-beta (GO:0035458)2.72580793
88positive regulation of natural killer cell differentiation (GO:0032825)2.71493435
89cellular protein complex disassembly (GO:0043624)2.70494480
90regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.70398761
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.69449032
92respiratory burst (GO:0045730)2.68973441
93opioid receptor signaling pathway (GO:0038003)2.68289526
94L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67969423
95neutrophil activation involved in immune response (GO:0002283)2.66973484
96regulation of immunoglobulin secretion (GO:0051023)2.66751017
97definitive hemopoiesis (GO:0060216)2.66612216
98negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.65849944
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.65441664
100response to protozoan (GO:0001562)2.65193664
101angiogenesis involved in wound healing (GO:0060055)2.63946877
102ubiquinone biosynthetic process (GO:0006744)2.63603303
103protein K11-linked deubiquitination (GO:0035871)2.62767293
104necroptotic process (GO:0070266)2.62672021
105negative regulation of interleukin-1 production (GO:0032692)2.61697123
106tryptophan metabolic process (GO:0006568)2.60260124
107tumor necrosis factor-mediated signaling pathway (GO:0033209)2.59834871
108regulation of response to interferon-gamma (GO:0060330)2.58974000
109positive regulation of granulocyte differentiation (GO:0030854)2.58607883
110B cell mediated immunity (GO:0019724)2.58133836
111translational initiation (GO:0006413)2.57712502
112DNA strand elongation (GO:0022616)2.57348841
113cellular biogenic amine catabolic process (GO:0042402)2.56944660
114amine catabolic process (GO:0009310)2.56944660
115positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55134599
116DNA deamination (GO:0045006)2.54922804
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.54446955
118thymic T cell selection (GO:0045061)2.54420500
119regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.54033589
120negative regulation of DNA-templated transcription, elongation (GO:0032785)2.53897923
121regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53047985
122positive regulation of fatty acid oxidation (GO:0046321)2.52670880
123lymphocyte homeostasis (GO:0002260)2.52182640
124mature B cell differentiation involved in immune response (GO:0002313)2.51729908
125base-excision repair, AP site formation (GO:0006285)2.51646901
126platelet dense granule organization (GO:0060155)2.50572461
127pentose-phosphate shunt (GO:0006098)2.50506431
128cellular response to zinc ion (GO:0071294)2.50072448
129negative regulation of tumor necrosis factor production (GO:0032720)2.49358443
130positive regulation of histone deacetylation (GO:0031065)2.48576516
131regulation of T cell receptor signaling pathway (GO:0050856)2.47846253
132hepatocyte apoptotic process (GO:0097284)2.46206942
133purinergic nucleotide receptor signaling pathway (GO:0035590)2.45674304
134defense response to protozoan (GO:0042832)2.44958487
135NAD biosynthetic process (GO:0009435)2.44439050
136DNA methylation involved in gamete generation (GO:0043046)2.43849688
137megakaryocyte development (GO:0035855)2.43496793
138regulation of alpha-beta T cell proliferation (GO:0046640)2.41864260
139telomere maintenance via recombination (GO:0000722)2.41413869
140C-terminal protein amino acid modification (GO:0018410)2.41234469
141positive regulation of lamellipodium organization (GO:1902745)2.41219900
142regulation of cilium movement (GO:0003352)2.40967514
143auditory receptor cell stereocilium organization (GO:0060088)2.40937014
144maintenance of protein location in nucleus (GO:0051457)2.40812486
145negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.40572094
146L-fucose catabolic process (GO:0042355)2.40483356
147fucose catabolic process (GO:0019317)2.40483356
148L-fucose metabolic process (GO:0042354)2.40483356
149mature B cell differentiation (GO:0002335)2.40312114
150negative regulation of interleukin-12 production (GO:0032695)2.40267422
151GDP-mannose metabolic process (GO:0019673)2.40132767
152positive regulation of macrophage differentiation (GO:0045651)2.39966872
153negative regulation of nitric oxide biosynthetic process (GO:0045019)2.39925721
154CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.39468659
155T-helper cell differentiation (GO:0042093)2.39468659
156JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39188475
157protein complex disassembly (GO:0043241)2.36861811
158regulation of T cell mediated cytotoxicity (GO:0001914)2.36680780
159antigen receptor-mediated signaling pathway (GO:0050851)2.36275959
160positive regulation of alpha-beta T cell proliferation (GO:0046641)2.36223173
161positive regulation of interferon-alpha production (GO:0032727)2.34412926
162sulfate transport (GO:0008272)2.34344586
163negative regulation of interleukin-1 beta production (GO:0032691)2.34170540
164cellular response to exogenous dsRNA (GO:0071360)2.33879442
165cytidine deamination (GO:0009972)2.33551138
166cytidine metabolic process (GO:0046087)2.33551138
167cytidine catabolic process (GO:0006216)2.33551138
168T cell apoptotic process (GO:0070231)2.33495866
169signal peptide processing (GO:0006465)2.32928187
170lymph node development (GO:0048535)2.32534725
171cell wall macromolecule metabolic process (GO:0044036)2.32262557
172purine-containing compound salvage (GO:0043101)2.31816548
173interferon-gamma secretion (GO:0072643)2.31072642
174glutathione biosynthetic process (GO:0006750)2.30821239
175negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.30759287
176negative regulation of cell killing (GO:0031342)2.30759287
177organic cation transport (GO:0015695)2.30289265
178regulation of regulatory T cell differentiation (GO:0045589)2.30257829
179valine metabolic process (GO:0006573)2.29827678
180response to interferon-beta (GO:0035456)2.29515078
181natural killer cell differentiation (GO:0001779)2.29398651
182leukocyte homeostasis (GO:0001776)2.29347751
183positive regulation of protein deacetylation (GO:0090312)2.28023103
184interferon-gamma-mediated signaling pathway (GO:0060333)2.27786410
185diterpenoid biosynthetic process (GO:0016102)2.27372530
186leukocyte cell-cell adhesion (GO:0007159)2.27168539
187myeloid dendritic cell activation (GO:0001773)2.26340843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.68599852
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.62612299
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98684912
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.84645367
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.82560661
6MYC_22102868_ChIP-Seq_BL_Human2.75699042
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.74194092
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.64499072
9VDR_21846776_ChIP-Seq_THP-1_Human2.57213068
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52580222
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.52289448
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.49714420
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45382039
14BCL6_27268052_Chip-Seq_Bcells_Human2.42624800
15ELF1_20517297_ChIP-Seq_JURKAT_Human2.40044482
16SCL_19346495_ChIP-Seq_HPC-7_Human2.39484960
17MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38885018
18RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35980207
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.29689382
20ZNF274_21170338_ChIP-Seq_K562_Hela2.26874992
21CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.17267147
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.11153029
23MYB_26560356_Chip-Seq_TH2_Human2.09049178
24P68_20966046_ChIP-Seq_HELA_Human2.08490156
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.07606431
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.06985803
27* MAF_26560356_Chip-Seq_TH1_Human2.02756424
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.01801495
29* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.01246550
30E2F1_20622854_ChIP-Seq_HELA_Human2.01162757
31EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.99408579
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96311855
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95839257
34BCOR_27268052_Chip-Seq_Bcells_Human1.95224710
35SPI1_23547873_ChIP-Seq_NB4_Human1.91514721
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89131670
37VDR_24763502_ChIP-Seq_THP-1_Human1.87448746
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.87369785
39UTX_26944678_Chip-Seq_JUKART_Human1.86232002
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85559656
41ERA_21632823_ChIP-Seq_H3396_Human1.83536996
42* SRF_21415370_ChIP-Seq_HL-1_Mouse1.79702863
43PHF8_20622854_ChIP-Seq_HELA_Human1.79174520
44MYB_26560356_Chip-Seq_TH1_Human1.77952247
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.77556072
46YY1_22570637_ChIP-Seq_MALME-3M_Human1.75972311
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.74812363
48ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73147835
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71577617
50NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71405029
51NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71341357
52RUNX1_22412390_ChIP-Seq_EML_Mouse1.70072077
53SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.68292815
54E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67999451
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.66958852
56VDR_22108803_ChIP-Seq_LS180_Human1.66579327
57CTCF_20526341_ChIP-Seq_ESCs_Human1.65677341
58MYC_18555785_ChIP-Seq_MESCs_Mouse1.65596634
59P300_27268052_Chip-Seq_Bcells_Human1.64715500
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.64205657
61LXR_22292898_ChIP-Seq_THP-1_Human1.61709419
62* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60422180
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.59828767
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56185560
65CTCF_26484167_Chip-Seq_Bcells_Mouse1.55893749
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55277903
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52564299
68MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52522200
69TCF7_22412390_ChIP-Seq_EML_Mouse1.52498345
70VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.52293274
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52182377
72FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50531726
73GATA1_22025678_ChIP-Seq_K562_Human1.50113749
74RUNX_20019798_ChIP-Seq_JUKART_Human1.49409565
75MAF_26560356_Chip-Seq_TH2_Human1.47497806
76CIITA_25753668_ChIP-Seq_RAJI_Human1.46407858
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.45222861
78RARB_24833708_ChIP-Seq_LIVER_Mouse1.44536262
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.43659137
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.42969166
81OCT4_20526341_ChIP-Seq_ESCs_Human1.42959134
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42495215
83RAC3_21632823_ChIP-Seq_H3396_Human1.42010095
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.41004428
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40723301
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40612475
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39404517
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.38658369
89STAT1_20625510_ChIP-Seq_HELA_Human1.38113391
90SA1_27219007_Chip-Seq_Bcells_Human1.35580377
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.35370273
92FOXP3_21729870_ChIP-Seq_TREG_Human1.34994131
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.34555736
94CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32950197
95RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.32248841
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32007563
97VDR_23849224_ChIP-Seq_CD4+_Human1.31608187
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28973775
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28644267
100KDM5A_27292631_Chip-Seq_BREAST_Human1.27533867
101XRN2_22483619_ChIP-Seq_HELA_Human1.26879040
102* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.26436405
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.25937856
104CTCF_27219007_Chip-Seq_Bcells_Human1.24407541
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24084241
106KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24081879
107P53_21459846_ChIP-Seq_SAOS-2_Human1.24028498
108GABP_17652178_ChIP-ChIP_JURKAT_Human1.23363796
109TAF2_19829295_ChIP-Seq_ESCs_Human1.23337323
110RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.23161775
111PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20474402
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.20159893
113GATA3_21878914_ChIP-Seq_MCF-7_Human1.20148354
114P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.19652716
115GATA3_27048872_Chip-Seq_THYMUS_Human1.18280022
116NOTCH1_21737748_ChIP-Seq_TLL_Human1.17802320
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17754570
118EST1_17652178_ChIP-ChIP_JURKAT_Human1.17187261
119CTCF_27219007_Chip-Seq_ERYTHROID_Human1.16573126
120ETS1_20019798_ChIP-Seq_JURKAT_Human1.16387475
121KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15676969
122DCP1A_22483619_ChIP-Seq_HELA_Human1.15457174
123TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15158678
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14690902
125* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14198003
126CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.13579588
127MYC_19829295_ChIP-Seq_ESCs_Human1.13377592
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12876392
129GABP_19822575_ChIP-Seq_HepG2_Human1.12653342
130TFEB_21752829_ChIP-Seq_HELA_Human1.12427567
131RXR_22158963_ChIP-Seq_LIVER_Mouse1.12063455
132JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10947103
133TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10391676
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10303133
135TP63_22573176_ChIP-Seq_HFKS_Human1.10194187
136SMC4_20622854_ChIP-Seq_HELA_Human1.08578887
137SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08465031
138CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08005642
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07666270
140NANOG_20526341_ChIP-Seq_ESCs_Human1.07523585
141ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07350157
142SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06948000
143TP53_22573176_ChIP-Seq_HFKS_Human1.05882866
144CTCF_21964334_Chip-Seq_Bcells_Human1.05878414
145* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05384056
146SPI1_23127762_ChIP-Seq_K562_Human1.05361820
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04546264
148E2F1_21310950_ChIP-Seq_MCF-7_Human1.03938597
149DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02665174
150HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02526356
151EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02472835
152MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01981046
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01488474
154MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01144533
155OCT4_19829295_ChIP-Seq_ESCs_Human0.99467267
156GATA3_26560356_Chip-Seq_TH2_Human0.99152559
157* KDM2B_26808549_Chip-Seq_DND41_Human0.98944712
158PU_27001747_Chip-Seq_BMDM_Mouse0.98463111
159AR_21909140_ChIP-Seq_LNCAP_Human0.97607673
160CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96819405
161RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96731000
162NELFA_20434984_ChIP-Seq_ESCs_Mouse0.96638271
163SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94897592
164KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.93387773
165CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93237758

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.31269768
2MP0000685_abnormal_immune_system2.92876784
3MP0003763_abnormal_thymus_physiology2.85123296
4MP0003436_decreased_susceptibility_to2.72958682
5MP0003172_abnormal_lysosome_physiology2.63297815
6MP0002396_abnormal_hematopoietic_system2.63199222
7MP0001800_abnormal_humoral_immune2.60811878
8MP0005671_abnormal_response_to2.58689934
9MP0009785_altered_susceptibility_to2.58502275
10MP0005387_immune_system_phenotype2.51709219
11MP0001790_abnormal_immune_system2.51709219
12MP0006292_abnormal_olfactory_placode2.41674207
13MP0002166_altered_tumor_susceptibility2.40117558
14MP0005025_abnormal_response_to2.37723040
15MP0005000_abnormal_immune_tolerance2.34677633
16MP0002452_abnormal_antigen_presenting2.33883197
17MP0002420_abnormal_adaptive_immunity2.31717053
18MP0002723_abnormal_immune_serum2.31530511
19MP0001819_abnormal_immune_cell2.28875356
20MP0002398_abnormal_bone_marrow2.25120688
21MP0003011_delayed_dark_adaptation2.21503911
22MP0009333_abnormal_splenocyte_physiolog2.16826187
23MP0005464_abnormal_platelet_physiology2.15708232
24MP0002419_abnormal_innate_immunity2.13145253
25MP0004808_abnormal_hematopoietic_stem2.06939913
26MP0002148_abnormal_hypersensitivity_rea2.06742290
27MP0003724_increased_susceptibility_to2.00954703
28MP0000716_abnormal_immune_system2.00839395
29MP0002405_respiratory_system_inflammati1.97586125
30MP0000689_abnormal_spleen_morphology1.96511672
31MP0010155_abnormal_intestine_physiology1.94729828
32MP0002722_abnormal_immune_system1.94218350
33MP0002277_abnormal_respiratory_mucosa1.88894980
34MP0002006_tumorigenesis1.84207619
35MP0000490_abnormal_crypts_of1.80953313
36MP0002429_abnormal_blood_cell1.78970491
37MP0005397_hematopoietic_system_phenotyp1.78224677
38MP0001545_abnormal_hematopoietic_system1.78224677
39MP0005645_abnormal_hypothalamus_physiol1.75966475
40MP0001501_abnormal_sleep_pattern1.74718669
41MP0001873_stomach_inflammation1.72790547
42MP0009840_abnormal_foam_cell1.72764705
43MP0003303_peritoneal_inflammation1.70857323
44MP0003191_abnormal_cellular_cholesterol1.70009402
45MP0001853_heart_inflammation1.66329700
46MP0001845_abnormal_inflammatory_respons1.66269202
47MP0003300_gastrointestinal_ulcer1.65272771
48MP0004043_abnormal_pH_regulation1.64522313
49MP0001968_abnormal_touch/_nociception1.63427641
50MP0004947_skin_inflammation1.63384091
51MP0008872_abnormal_physiological_respon1.63033696
52MP0000703_abnormal_thymus_morphology1.60679113
53MP0003866_abnormal_defecation1.58759562
54MP0004133_heterotaxia1.56875954
55MP0000465_gastrointestinal_hemorrhage1.50999327
56MP0003787_abnormal_imprinting1.49490782
57MP0001986_abnormal_taste_sensitivity1.45414387
58MP0000858_altered_metastatic_potential1.44960128
59MP0002693_abnormal_pancreas_physiology1.43174064
60MP0006082_CNS_inflammation1.40548629
61MP0008469_abnormal_protein_level1.39929310
62MP0003646_muscle_fatigue1.38984972
63MP0006054_spinal_hemorrhage1.37674577
64MP0006072_abnormal_retinal_apoptosis1.37340001
65MP0000015_abnormal_ear_pigmentation1.36006987
66MP0010352_gastrointestinal_tract_polyps1.35880687
67MP0002638_abnormal_pupillary_reflex1.35520006
68MP0002876_abnormal_thyroid_physiology1.35256821
69MP0005551_abnormal_eye_electrophysiolog1.35075683
70MP0002933_joint_inflammation1.34523284
71MP0002877_abnormal_melanocyte_morpholog1.33749076
72MP0001764_abnormal_homeostasis1.33037104
73MP0005360_urolithiasis1.32846523
74MP0001533_abnormal_skeleton_physiology1.31455591
75MP0002019_abnormal_tumor_incidence1.29193201
76MP0003693_abnormal_embryo_hatching1.28336720
77MP0002102_abnormal_ear_morphology1.24550931
78MP0002254_reproductive_system_inflammat1.24117976
79MP0001663_abnormal_digestive_system1.23212896
80MP0008007_abnormal_cellular_replicative1.22834106
81MP0004381_abnormal_hair_follicle1.21816394
82MP0003077_abnormal_cell_cycle1.20049059
83MP0005023_abnormal_wound_healing1.19954778
84MP0000538_abnormal_urinary_bladder1.15756153
85MP0005058_abnormal_lysosome_morphology1.09992558
86MP0003806_abnormal_nucleotide_metabolis1.08461206
87MP0002132_abnormal_respiratory_system1.07379111
88MP0005167_abnormal_blood-brain_barrier1.07368512
89MP0004510_myositis1.06124844
90MP0000372_irregular_coat_pigmentation1.05670497
91MP0003283_abnormal_digestive_organ1.03767489
92MP0002837_dystrophic_cardiac_calcinosis1.03686595
93MP0001765_abnormal_ion_homeostasis1.03590135
94MP0000609_abnormal_liver_physiology1.01613788
95MP0002735_abnormal_chemical_nociception1.00494912
96MP0000343_altered_response_to1.00462546
97MP0003195_calcinosis1.00296163
98MP0010094_abnormal_chromosome_stability0.99946212
99MP0001944_abnormal_pancreas_morphology0.99880214
100MP0009764_decreased_sensitivity_to0.99810148
101MP0001502_abnormal_circadian_rhythm0.99678916
102MP0000013_abnormal_adipose_tissue0.99548877
103MP0003448_altered_tumor_morphology0.99318926
104MP0006036_abnormal_mitochondrial_physio0.99211306
105MP0000230_abnormal_systemic_arterial0.99127692
106MP0002653_abnormal_ependyma_morphology0.98874014
107MP0009384_cardiac_valve_regurgitation0.97273047
108MP0002736_abnormal_nociception_after0.95278096
109MP0004957_abnormal_blastocyst_morpholog0.94778001
110MP0005075_abnormal_melanosome_morpholog0.92349994
111MP0003656_abnormal_erythrocyte_physiolo0.92173626
112MP0009763_increased_sensitivity_to0.91560316
113MP0003045_fibrosis0.90884423
114MP0004145_abnormal_muscle_electrophysio0.90296423
115MP0000598_abnormal_liver_morphology0.90157308
116MP0003705_abnormal_hypodermis_morpholog0.89325583
117MP0010307_abnormal_tumor_latency0.89072716
118MP0005257_abnormal_intraocular_pressure0.87987530
119MP0003111_abnormal_nucleus_morphology0.87237349
120MP0005381_digestive/alimentary_phenotyp0.86729872
121MP0006035_abnormal_mitochondrial_morpho0.86115013
122MP0002998_abnormal_bone_remodeling0.84940110
123MP0009278_abnormal_bone_marrow0.84730336
124MP0005410_abnormal_fertilization0.84413069
125MP0005535_abnormal_body_temperature0.83497721
126MP0003186_abnormal_redox_activity0.83077237
127MP0005310_abnormal_salivary_gland0.82978436
128MP0008789_abnormal_olfactory_epithelium0.82339376
129MP0000371_diluted_coat_color0.82197777
130MP0005084_abnormal_gallbladder_morpholo0.80897902
131MP0001919_abnormal_reproductive_system0.80326478
132MP0005174_abnormal_tail_pigmentation0.80171783
133MP0003566_abnormal_cell_adhesion0.79689424
134MP0003279_aneurysm0.78741963
135MP0008873_increased_physiological_sensi0.78332680
136MP0008995_early_reproductive_senescence0.75654171
137MP0008875_abnormal_xenobiotic_pharmacok0.75243632
138MP0002139_abnormal_hepatobiliary_system0.75241050
139MP0003943_abnormal_hepatobiliary_system0.74495494
140MP0000477_abnormal_intestine_morphology0.74433386
141MP0002138_abnormal_hepatobiliary_system0.74410029
142MP0009643_abnormal_urine_homeostasis0.73942523
143MP0002136_abnormal_kidney_physiology0.71802169
144MP0000249_abnormal_blood_vessel0.71725852
145MP0005365_abnormal_bile_salt0.69701050
146MP0000313_abnormal_cell_death0.68179944
147MP0005166_decreased_susceptibility_to0.67689552
148MP0008438_abnormal_cutaneous_collagen0.65178865
149MP0005319_abnormal_enzyme/_coenzyme0.64840271
150MP0005584_abnormal_enzyme/coenzyme_acti0.64547772
151MP0001243_abnormal_dermal_layer0.64545424
152MP0003091_abnormal_cell_migration0.62938051
153MP0003795_abnormal_bone_structure0.62228328

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)4.64760801
2Elevated erythrocyte sedimentation rate (HP:0003565)4.48706957
3Eczematoid dermatitis (HP:0000976)4.21533360
4Recurrent abscess formation (HP:0002722)4.17645947
5IgM deficiency (HP:0002850)4.17061794
6Myositis (HP:0100614)4.16840939
7Chronic otitis media (HP:0000389)4.06229131
8Recurrent bacterial skin infections (HP:0005406)3.80902777
9Recurrent bronchitis (HP:0002837)3.57102826
10J-shaped sella turcica (HP:0002680)3.47563324
11Recurrent viral infections (HP:0004429)3.46253803
12Type II lissencephaly (HP:0007260)3.42559612
13Molar tooth sign on MRI (HP:0002419)3.35568286
14Abnormality of midbrain morphology (HP:0002418)3.35568286
15Cellulitis (HP:0100658)3.32258888
16Recurrent fungal infections (HP:0002841)3.30963174
17Pancreatic cysts (HP:0001737)3.28376362
18Petechiae (HP:0000967)3.20377661
19Nephronophthisis (HP:0000090)3.17999496
20Abnormality of T cells (HP:0002843)3.15893252
21True hermaphroditism (HP:0010459)3.10080781
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.09271924
23Autoimmune thrombocytopenia (HP:0001973)3.07640836
24T lymphocytopenia (HP:0005403)3.05523052
25Congenital stationary night blindness (HP:0007642)3.05397054
26Nasal polyposis (HP:0100582)3.04964275
27Abnormal rod and cone electroretinograms (HP:0008323)3.02679244
28Pancreatic fibrosis (HP:0100732)3.00953765
29Meningitis (HP:0001287)3.00013677
30Abnormality of T cell number (HP:0011839)2.98598122
31Abnormality of T cell physiology (HP:0011840)2.98049358
32Prolonged bleeding time (HP:0003010)2.90338031
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.90315969
34Spontaneous hematomas (HP:0007420)2.85035937
35Epistaxis (HP:0000421)2.80767885
36Abnormality of the nasal mucosa (HP:0000433)2.79679228
37Panhypogammaglobulinemia (HP:0003139)2.78251718
38Pendular nystagmus (HP:0012043)2.78024141
39Aplastic anemia (HP:0001915)2.77856941
40Chronic hepatic failure (HP:0100626)2.77185510
41Cystic liver disease (HP:0006706)2.76936977
42Abnormality of cells of the erythroid lineage (HP:0012130)2.76664114
43Pustule (HP:0200039)2.72456675
44Hepatocellular necrosis (HP:0001404)2.72131827
45Abnormality of macrophages (HP:0004311)2.71457857
46Abnormal number of erythroid precursors (HP:0012131)2.69224108
47Attenuation of retinal blood vessels (HP:0007843)2.68524499
48Recurrent skin infections (HP:0001581)2.66923673
49Recurrent gram-negative bacterial infections (HP:0005420)2.64786442
50Abnormality of B cell number (HP:0010975)2.63339956
51B lymphocytopenia (HP:0010976)2.63339956
52Lymphopenia (HP:0001888)2.63159827
53Mesangial abnormality (HP:0001966)2.61647121
54Gingival bleeding (HP:0000225)2.61411407
55Abnormal platelet function (HP:0011869)2.60571697
56Impaired platelet aggregation (HP:0003540)2.60571697
57Interstitial pulmonary disease (HP:0006530)2.59582185
58Cerebellar dysplasia (HP:0007033)2.57629659
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.57291796
60Abnormality of the renal medulla (HP:0100957)2.54651266
61Reticulocytopenia (HP:0001896)2.54438511
62Vasculitis (HP:0002633)2.52770058
63Optic nerve coloboma (HP:0000588)2.51408276
64Abnormal drinking behavior (HP:0030082)2.50063918
65Polydipsia (HP:0001959)2.50063918
663-Methylglutaconic aciduria (HP:0003535)2.49786267
67Abnormal platelet volume (HP:0011876)2.47771321
68Agammaglobulinemia (HP:0004432)2.46345335
69IgG deficiency (HP:0004315)2.45915253
70Abnormality of mucopolysaccharide metabolism (HP:0011020)2.43904145
71Abnormality of polysaccharide metabolism (HP:0011012)2.43904145
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.43904145
73Orchitis (HP:0100796)2.41725257
74Tubular atrophy (HP:0000092)2.41192668
75Ketosis (HP:0001946)2.40804887
76Gastrointestinal inflammation (HP:0004386)2.39210942
77Mitochondrial inheritance (HP:0001427)2.38987845
78Inflammation of the large intestine (HP:0002037)2.38418276
79Combined immunodeficiency (HP:0005387)2.37432491
80Keratitis (HP:0000491)2.36586761
81Hepatic necrosis (HP:0002605)2.36454048
82Chronic obstructive pulmonary disease (HP:0006510)2.35824153
83Obstructive lung disease (HP:0006536)2.35824153
84Increased IgE level (HP:0003212)2.35542995
85Dysostosis multiplex (HP:0000943)2.34403953
86Purpura (HP:0000979)2.34259553
87Stomach cancer (HP:0012126)2.32350521
88Severe muscular hypotonia (HP:0006829)2.32166696
89Abnormality of the renal cortex (HP:0011035)2.30819751
90Mediastinal lymphadenopathy (HP:0100721)2.30782501
91Occipital encephalocele (HP:0002085)2.30451633
92Large for gestational age (HP:0001520)2.30287733
93Arterial thrombosis (HP:0004420)2.29118602
94Increased IgM level (HP:0003496)2.28833179
95Progressive microcephaly (HP:0000253)2.28058122
96Dicarboxylic aciduria (HP:0003215)2.28037146
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.28037146
98Mucopolysacchariduria (HP:0008155)2.27704512
99Urinary glycosaminoglycan excretion (HP:0003541)2.27704512
100Abnormality of lateral ventricle (HP:0030047)2.25773688
101Encephalitis (HP:0002383)2.24595347
102Hypergammaglobulinemia (HP:0010702)2.22837813
103Gastrointestinal stroma tumor (HP:0100723)2.22168785
104Stomatitis (HP:0010280)2.20651009
105Conical tooth (HP:0000698)2.18048379
106Decreased circulating renin level (HP:0003351)2.17316136
107Verrucae (HP:0200043)2.15821140
108Papilloma (HP:0012740)2.15821140
109Severe combined immunodeficiency (HP:0004430)2.15507079
110Nonimmune hydrops fetalis (HP:0001790)2.15197358
111Osteomyelitis (HP:0002754)2.14681184
112Increased serum ferritin (HP:0003281)2.13869495
113Chest pain (HP:0100749)2.13084656
114Severe visual impairment (HP:0001141)2.12998873
115Congenital hepatic fibrosis (HP:0002612)2.12044237
116Abnormality of the prostate (HP:0008775)2.09611518
117Leukocytosis (HP:0001974)2.09463848
118Microcytic anemia (HP:0001935)2.09238079
119Vacuolated lymphocytes (HP:0001922)2.08534660
120Increased neuronal autofluorescent lipopigment (HP:0002074)2.07277729
121IgA deficiency (HP:0002720)2.07209431
122Lymphoma (HP:0002665)2.05420132
123Tented upper lip vermilion (HP:0010804)2.05163714
124Concave nail (HP:0001598)2.03841270
125Increased CSF lactate (HP:0002490)2.03806341
126Thoracic kyphosis (HP:0002942)2.02469437
127Cerebral palsy (HP:0100021)2.01763039
128Entropion (HP:0000621)2.00024719
129Reduced antithrombin III activity (HP:0001976)1.99988508
130Abnormal mitochondria in muscle tissue (HP:0008316)1.99519221
131Eosinophilia (HP:0001880)1.99306716
132Abnormal biliary tract physiology (HP:0012439)1.99296834
133Bile duct proliferation (HP:0001408)1.99296834
134Joint stiffness (HP:0001387)1.99283449
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98667984
136Increased mean platelet volume (HP:0011877)1.97968031
137Chronic mucocutaneous candidiasis (HP:0002728)1.97219735
138Recurrent cutaneous fungal infections (HP:0011370)1.97219735
139Autoimmune hemolytic anemia (HP:0001890)1.96831028
140Abnormality of the fingertips (HP:0001211)1.96493326
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95524113
142Pallor (HP:0000980)1.95311189
143Large eyes (HP:0001090)1.94910100
144Ketoacidosis (HP:0001993)1.94422868
145Emphysema (HP:0002097)1.93529692
146Skin rash (HP:0000988)1.93302479
147Colitis (HP:0002583)1.92835974
148Acute necrotizing encephalopathy (HP:0006965)1.92830228
149Joint swelling (HP:0001386)1.92822581
150Granulocytopenia (HP:0001913)1.92603180
151Skin ulcer (HP:0200042)1.91642915
152Poikiloderma (HP:0001029)1.91338592
153Abnormality of iron homeostasis (HP:0011031)1.91126197
154Multiple enchondromatosis (HP:0005701)1.90828103
155Hypoplasia of the pons (HP:0012110)1.89689014
156Broad face (HP:0000283)1.89559220
157Recurrent sinusitis (HP:0011108)1.89123505
158Bronchitis (HP:0012387)1.88865311
159Optic neuritis (HP:0100653)1.87809329
160Retrobulbar optic neuritis (HP:0100654)1.87809329
161Microretrognathia (HP:0000308)1.86123895
162Abnormality of the pons (HP:0007361)1.85874411
163Polyuria (HP:0000103)1.85790609
164Abnormality of transition element cation homeostasis (HP:0011030)1.84873372
165Hypoplasia of the thymus (HP:0000778)1.82675887
166Neurodegeneration (HP:0002180)1.82549802
167Medial flaring of the eyebrow (HP:0010747)1.82339339
168Decreased electroretinogram (ERG) amplitude (HP:0000654)1.81985195
169Male pseudohermaphroditism (HP:0000037)1.81562117
170Urticaria (HP:0001025)1.81453541
171Chronic sinusitis (HP:0011109)1.80006833
172Testicular atrophy (HP:0000029)1.79503721
173Tachypnea (HP:0002789)1.76787036
174Furrowed tongue (HP:0000221)1.75724423
175Methylmalonic aciduria (HP:0012120)1.74835322
176Optic disc pallor (HP:0000543)1.74743530
177Hypoplasia of the fovea (HP:0007750)1.74723968
178Aplasia/Hypoplasia of the fovea (HP:0008060)1.74723968
179Clumsiness (HP:0002312)1.74155116
180Abnormal respiratory epithelium morphology (HP:0012253)1.74034660
181Abnormal respiratory motile cilium morphology (HP:0005938)1.74034660
182Acute encephalopathy (HP:0006846)1.73290899
183Increased corneal curvature (HP:0100692)1.72546438
184Keratoconus (HP:0000563)1.72546438
185Increased serum lactate (HP:0002151)1.71830123
186Abolished electroretinogram (ERG) (HP:0000550)1.71500458
187Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.71077716
188Abnormal albumin level (HP:0012116)1.70921361
189Hypoalbuminemia (HP:0003073)1.70921361

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.38015508
2MAP4K22.73053552
3NME22.53955183
4PKN22.53001422
5ADRBK22.51758773
6SIK22.50355156
7ERN12.49357821
8EEF2K2.33044524
9TLK12.21064920
10FRK2.20118137
11ZAP702.17979673
12JAK32.13723784
13TXK2.13373489
14VRK22.12621297
15PIM22.11312790
16KIT2.07281256
17TBK12.06396860
18TRIB32.04730651
19ZAK2.04674519
20TYK22.04143685
21MUSK2.01011978
22FLT31.97610337
23MAP3K101.96758724
24KDR1.95090596
25TEC1.94191206
26GRK61.91753677
27MAPK151.91685651
28BTK1.90235812
29STK101.86730405
30LRRK21.82327649
31MAP2K31.78458318
32SCYL21.68990751
33MAPK131.66647418
34PRKD21.66059957
35GRK11.59149724
36WNK41.57488207
37TESK21.57018439
38TAOK21.55204370
39CSF1R1.54290674
40PTK2B1.53319740
41ITK1.51209741
42BLK1.50493635
43MAP3K141.50311004
44INSRR1.48260540
45RPS6KA41.46769301
46IKBKE1.46227433
47SIK31.44045439
48IRAK11.37499773
49PIM11.34946634
50NUAK11.34020794
51FGFR41.26987135
52MAP3K111.26170242
53TGFBR11.25842238
54ACVR1B1.25234155
55SYK1.25146545
56NEK21.21586365
57CLK11.18665203
58WNK31.15655582
59TIE11.15189965
60IKBKB1.14616513
61MAP3K121.14303702
62JAK11.12552936
63LCK1.11870088
64RPS6KA21.10488395
65NME11.06855149
66NLK1.04292214
67BUB11.02798115
68BRSK20.99259515
69TGFBR20.98124266
70MARK30.96391520
71PINK10.91623449
72WEE10.89582001
73TRPM70.88646517
74TAOK10.88509786
75MAP3K30.87304055
76STK40.87266747
77LYN0.87082726
78ILK0.86463478
79HCK0.85979424
80IRAK40.85483624
81NEK90.84574671
82RPS6KB20.84007222
83CDK80.83898904
84TAOK30.82695055
85PRKCI0.81597873
86IRAK20.81095103
87MAP3K80.79330936
88BCKDK0.75741596
89MAP2K20.75415528
90DAPK20.75395401
91JAK20.72547839
92CDK40.70721991
93PAK40.69478590
94RPS6KA50.69367759
95TESK10.68131937
96EPHA20.67913325
97MAPK110.67611782
98VRK10.67282315
99TTN0.66605514
100EPHA30.65432066
101CSK0.64743050
102RIPK40.63697961
103CAMKK10.62603806
104SIK10.61357835
105CHUK0.59933802
106MAP3K130.58946970
107PTK60.58669045
108ADRBK10.58462628
109MATK0.57715166
110RPS6KA60.56807067
111TNK20.55603665
112MAP3K70.55117129
113MAPKAPK30.54236409
114MAPK120.53463877
115MAP3K60.53124745
116FGFR30.52096500
117CDK60.51985873
118MAP3K50.51622888
119EPHB10.50511792
120AURKB0.49880323
121BRSK10.49855839
122MAP2K60.49080079
123FES0.49070492
124MAPK40.48589435
125HIPK20.47415652
126PRKG20.47091559
127MARK20.46968520
128PRKCQ0.45360066
129MYLK0.43997701
130CDK70.43495573
131RAF10.43035279
132RPS6KL10.42819229
133RPS6KC10.42819229
134GRK70.41018768
135PRKCH0.40226101
136PASK0.39357255
137CAMKK20.38438972
138IRAK30.37775704
139MAPKAPK50.37670861
140BMPR1B0.37483074
141MAPK70.35589177
142PRKAA20.34118086
143STK160.33616372
144RPS6KA10.32405134
145MAPK30.32392065
146PRKAA10.32218394

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.25794047
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.20013485
3DNA replication_Homo sapiens_hsa030303.09945003
4Ribosome_Homo sapiens_hsa030102.80796480
5Base excision repair_Homo sapiens_hsa034102.43948282
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.40364635
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.38213443
8Mismatch repair_Homo sapiens_hsa034302.27847585
9Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.22306804
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.17126514
11Leishmaniasis_Homo sapiens_hsa051402.11962642
12Linoleic acid metabolism_Homo sapiens_hsa005912.06368976
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.04707412
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.00469508
15Measles_Homo sapiens_hsa051621.96747292
16B cell receptor signaling pathway_Homo sapiens_hsa046621.94151339
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.88284906
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87843915
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.79347181
20Autoimmune thyroid disease_Homo sapiens_hsa053201.79104511
21Caffeine metabolism_Homo sapiens_hsa002321.76665572
22Antigen processing and presentation_Homo sapiens_hsa046121.75163694
23Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.75022777
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.72183975
25Shigellosis_Homo sapiens_hsa051311.69784735
26Osteoclast differentiation_Homo sapiens_hsa043801.66168002
27Phototransduction_Homo sapiens_hsa047441.64341503
28Sulfur relay system_Homo sapiens_hsa041221.61392961
29Hematopoietic cell lineage_Homo sapiens_hsa046401.61019612
30Type I diabetes mellitus_Homo sapiens_hsa049401.56949340
31Ether lipid metabolism_Homo sapiens_hsa005651.53376321
32ABC transporters_Homo sapiens_hsa020101.52186177
33Oxidative phosphorylation_Homo sapiens_hsa001901.51333892
34Herpes simplex infection_Homo sapiens_hsa051681.49551907
35T cell receptor signaling pathway_Homo sapiens_hsa046601.43451834
36Proteasome_Homo sapiens_hsa030501.41742110
37Nucleotide excision repair_Homo sapiens_hsa034201.41126848
38One carbon pool by folate_Homo sapiens_hsa006701.40263443
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37720654
40Tryptophan metabolism_Homo sapiens_hsa003801.31396833
41Butanoate metabolism_Homo sapiens_hsa006501.31226115
42Acute myeloid leukemia_Homo sapiens_hsa052211.28639473
43Homologous recombination_Homo sapiens_hsa034401.28588888
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.26444329
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24282597
46Toxoplasmosis_Homo sapiens_hsa051451.23728844
47Apoptosis_Homo sapiens_hsa042101.23007404
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21414732
49Legionellosis_Homo sapiens_hsa051341.20428536
50Staphylococcus aureus infection_Homo sapiens_hsa051501.20398275
51Pentose phosphate pathway_Homo sapiens_hsa000301.20091758
52Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17306172
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16998927
54Folate biosynthesis_Homo sapiens_hsa007901.15844633
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.14812185
56Fanconi anemia pathway_Homo sapiens_hsa034601.14651514
57Influenza A_Homo sapiens_hsa051641.14142574
58Primary bile acid biosynthesis_Homo sapiens_hsa001201.12227911
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.12142883
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11596977
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10808316
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09642043
63Allograft rejection_Homo sapiens_hsa053301.09123016
64Rheumatoid arthritis_Homo sapiens_hsa053231.07833827
65Other glycan degradation_Homo sapiens_hsa005111.06096154
66Hepatitis B_Homo sapiens_hsa051611.03084339
67Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02352275
68Viral myocarditis_Homo sapiens_hsa054161.01998595
69Pyrimidine metabolism_Homo sapiens_hsa002401.01661992
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01076438
71Platelet activation_Homo sapiens_hsa046110.98792157
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.98774639
73Chronic myeloid leukemia_Homo sapiens_hsa052200.98698866
74Arachidonic acid metabolism_Homo sapiens_hsa005900.97803154
75p53 signaling pathway_Homo sapiens_hsa041150.97784761
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97509856
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.97217336
78Tuberculosis_Homo sapiens_hsa051520.94841770
79Cell cycle_Homo sapiens_hsa041100.94748093
80Thyroid cancer_Homo sapiens_hsa052160.93933809
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93624872
82Pertussis_Homo sapiens_hsa051330.91683909
83TNF signaling pathway_Homo sapiens_hsa046680.89852166
84Epstein-Barr virus infection_Homo sapiens_hsa051690.89496598
85Salmonella infection_Homo sapiens_hsa051320.86434741
86Parkinsons disease_Homo sapiens_hsa050120.84756481
87Protein export_Homo sapiens_hsa030600.84320044
88Peroxisome_Homo sapiens_hsa041460.84131152
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83574785
90N-Glycan biosynthesis_Homo sapiens_hsa005100.80858320
91Viral carcinogenesis_Homo sapiens_hsa052030.80699204
92Malaria_Homo sapiens_hsa051440.80087110
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79880963
94HTLV-I infection_Homo sapiens_hsa051660.78875341
95Small cell lung cancer_Homo sapiens_hsa052220.78510404
96Pancreatic cancer_Homo sapiens_hsa052120.77985269
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77704367
98Sulfur metabolism_Homo sapiens_hsa009200.77564054
99Regulation of autophagy_Homo sapiens_hsa041400.76225729
100Graft-versus-host disease_Homo sapiens_hsa053320.76206173
101Asthma_Homo sapiens_hsa053100.75368006
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75260689
103Chemical carcinogenesis_Homo sapiens_hsa052040.74558793
104Spliceosome_Homo sapiens_hsa030400.72128852
105Adipocytokine signaling pathway_Homo sapiens_hsa049200.71215341
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69487773
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.68988575
108Complement and coagulation cascades_Homo sapiens_hsa046100.65662524
109Hepatitis C_Homo sapiens_hsa051600.64797648
110Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64710063
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63861029
112Ovarian steroidogenesis_Homo sapiens_hsa049130.61607373
113Phenylalanine metabolism_Homo sapiens_hsa003600.60838070
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60692705
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59877436
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59588956
117Nitrogen metabolism_Homo sapiens_hsa009100.59443236
118Chemokine signaling pathway_Homo sapiens_hsa040620.58330438
119Glycerolipid metabolism_Homo sapiens_hsa005610.58028351
120Renin-angiotensin system_Homo sapiens_hsa046140.57247843
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56232073
122Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55742151
123Non-homologous end-joining_Homo sapiens_hsa034500.54652999
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54497717
125Lysosome_Homo sapiens_hsa041420.53811971
126Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53759140
127RNA polymerase_Homo sapiens_hsa030200.52908098
128Non-small cell lung cancer_Homo sapiens_hsa052230.52769077
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.52270879
130Basal transcription factors_Homo sapiens_hsa030220.51971190
131Metabolic pathways_Homo sapiens_hsa011000.50919266
132Selenocompound metabolism_Homo sapiens_hsa004500.49246095
133Huntingtons disease_Homo sapiens_hsa050160.48693698
134Collecting duct acid secretion_Homo sapiens_hsa049660.47349244
135Insulin resistance_Homo sapiens_hsa049310.45204137
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44733342
137Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.43168763
138RNA degradation_Homo sapiens_hsa030180.42570597
139Tyrosine metabolism_Homo sapiens_hsa003500.40951247
140Colorectal cancer_Homo sapiens_hsa052100.40316706
141Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38791593
142Retinol metabolism_Homo sapiens_hsa008300.38005262
143Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37907387
144Galactose metabolism_Homo sapiens_hsa000520.37709803
145Biosynthesis of amino acids_Homo sapiens_hsa012300.37392329
146VEGF signaling pathway_Homo sapiens_hsa043700.37271137
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37096635
148Glutathione metabolism_Homo sapiens_hsa004800.35856176
149Systemic lupus erythematosus_Homo sapiens_hsa053220.35501653
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32948262
151Fructose and mannose metabolism_Homo sapiens_hsa000510.29436064
152Sphingolipid metabolism_Homo sapiens_hsa006000.29140899

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