FBXO11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.46684407
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.32197238
3locomotory exploration behavior (GO:0035641)4.19858421
4presynaptic membrane assembly (GO:0097105)4.13656126
5neural tube formation (GO:0001841)4.13652053
6synaptic vesicle docking involved in exocytosis (GO:0016081)3.90457276
7regulation of synaptic vesicle exocytosis (GO:2000300)3.80900618
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.73457293
9layer formation in cerebral cortex (GO:0021819)3.70519344
10presynaptic membrane organization (GO:0097090)3.69177705
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.68052711
12synaptic vesicle exocytosis (GO:0016079)3.68002313
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.57695087
14regulation of glutamate receptor signaling pathway (GO:1900449)3.52543241
15negative regulation of neurotransmitter secretion (GO:0046929)3.51526754
16glutamate secretion (GO:0014047)3.47913353
17vocalization behavior (GO:0071625)3.45348946
18regulation of clathrin-mediated endocytosis (GO:2000369)3.41752811
19negative regulation of neurotransmitter transport (GO:0051589)3.35007041
20regulation of synaptic vesicle transport (GO:1902803)3.28760394
21regulation of long-term neuronal synaptic plasticity (GO:0048169)3.20842627
22exploration behavior (GO:0035640)3.19933039
23limb bud formation (GO:0060174)3.19515028
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.19202489
25pyrimidine nucleobase catabolic process (GO:0006208)3.15678148
26establishment of nucleus localization (GO:0040023)3.13750206
27dendritic spine morphogenesis (GO:0060997)3.12716576
28monoubiquitinated protein deubiquitination (GO:0035520)3.11896427
29regulation of neuronal synaptic plasticity (GO:0048168)3.09117651
30epithelial cell differentiation involved in kidney development (GO:0035850)3.07958154
31interkinetic nuclear migration (GO:0022027)3.05184434
32axonal fasciculation (GO:0007413)3.01670245
33proline transport (GO:0015824)3.00394755
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.99927301
35negative regulation of translation, ncRNA-mediated (GO:0040033)2.99927301
36regulation of translation, ncRNA-mediated (GO:0045974)2.99927301
37short-term memory (GO:0007614)2.99662864
38dendrite morphogenesis (GO:0048813)2.97407382
39keratinocyte development (GO:0003334)2.96289703
40protein localization to synapse (GO:0035418)2.96255208
41response to pheromone (GO:0019236)2.94417142
42regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.93030728
43clathrin coat assembly (GO:0048268)2.92605120
44peptidyl-threonine dephosphorylation (GO:0035970)2.92272094
45neurotransmitter secretion (GO:0007269)2.89042582
46neuron recognition (GO:0008038)2.86580044
47head development (GO:0060322)2.86318744
48neuronal action potential propagation (GO:0019227)2.85061571
49microtubule anchoring (GO:0034453)2.83681980
50establishment of mitochondrion localization (GO:0051654)2.83196309
51vesicle transport along microtubule (GO:0047496)2.81939946
52activation of protein kinase A activity (GO:0034199)2.80539457
53regulation of synapse structural plasticity (GO:0051823)2.80035342
54central nervous system projection neuron axonogenesis (GO:0021952)2.77261597
55neuron cell-cell adhesion (GO:0007158)2.77210412
56regulation of ARF protein signal transduction (GO:0032012)2.77055832
57positive regulation of cardiac muscle cell differentiation (GO:2000727)2.76594972
58startle response (GO:0001964)2.75921488
59cerebral cortex cell migration (GO:0021795)2.75885444
60glutamate receptor signaling pathway (GO:0007215)2.73470590
61regulation of growth hormone secretion (GO:0060123)2.69863832
62negative regulation of sodium ion transport (GO:0010766)2.68082282
63establishment of protein localization to Golgi (GO:0072600)2.67501878
64G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66149729
65synaptic transmission, glutamatergic (GO:0035249)2.63751505
66phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.62488021
67dendritic spine organization (GO:0097061)2.60899192
68regulation of dendritic spine morphogenesis (GO:0061001)2.60762092
69gamma-aminobutyric acid transport (GO:0015812)2.60010848
70glial cell proliferation (GO:0014009)2.59986817
71cellular potassium ion homeostasis (GO:0030007)2.59437049
72protein targeting to Golgi (GO:0000042)2.59175544
73neurotransmitter-gated ion channel clustering (GO:0072578)2.57627965
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57475722
75synapse assembly (GO:0007416)2.54198243
76auditory behavior (GO:0031223)2.53619994
77neuromuscular process controlling balance (GO:0050885)2.53308481
78cell migration in hindbrain (GO:0021535)2.51929347
79cytoplasmic mRNA processing body assembly (GO:0033962)2.50556911
80axon extension (GO:0048675)2.50414227
81regulation of excitatory postsynaptic membrane potential (GO:0060079)2.49822310
82retrograde transport, vesicle recycling within Golgi (GO:0000301)2.49309964
83cerebellar granule cell differentiation (GO:0021707)2.47352550
84regulation of synaptic plasticity (GO:0048167)2.47225213
85corticosteroid receptor signaling pathway (GO:0031958)2.47040393
86neuron-neuron synaptic transmission (GO:0007270)2.46235364
87olfactory bulb development (GO:0021772)2.45919903
88glucocorticoid receptor signaling pathway (GO:0042921)2.45676658
89long-term memory (GO:0007616)2.45414606
90synaptic vesicle endocytosis (GO:0048488)2.44613627
91positive regulation of male gonad development (GO:2000020)2.44604207
92C4-dicarboxylate transport (GO:0015740)2.44459284
93establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.44434572
94mitochondrion transport along microtubule (GO:0047497)2.44434572
95cerebellar Purkinje cell differentiation (GO:0021702)2.43834928
96positive regulation of heart growth (GO:0060421)2.43471713
97tachykinin receptor signaling pathway (GO:0007217)2.43275207
98secondary heart field specification (GO:0003139)2.42082632
99heart field specification (GO:0003128)2.42082632
100peptidyl-threonine phosphorylation (GO:0018107)2.39842417
101sodium ion export (GO:0071436)2.39449512
102regulation of development, heterochronic (GO:0040034)2.39424388
103gastrulation with mouth forming second (GO:0001702)2.39331792
104innervation (GO:0060384)2.38806394
105long-term synaptic potentiation (GO:0060291)2.38763491
106positive regulation of synapse maturation (GO:0090129)2.37856530
107regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.37506102
108gamma-aminobutyric acid signaling pathway (GO:0007214)2.37278065
109negative regulation of cell killing (GO:0031342)2.36613251
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36613251
111regulation of RNA export from nucleus (GO:0046831)2.36204348
112regulation of cAMP-dependent protein kinase activity (GO:2000479)2.34213357
113regulation of postsynaptic membrane potential (GO:0060078)2.33789895
114protein targeting to lysosome (GO:0006622)2.32845738
115establishment of protein localization to vacuole (GO:0072666)2.32845738
116protein targeting to vacuole (GO:0006623)2.32845738
117epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.32362378
118nucleobase catabolic process (GO:0046113)2.31610860
119neuron remodeling (GO:0016322)2.31576376
120regulation of Rac protein signal transduction (GO:0035020)2.31298259
121positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.31134039
122mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.31134039
123spinal cord development (GO:0021510)2.29174718
124sympathetic nervous system development (GO:0048485)2.28973243
125positive regulation of growth hormone secretion (GO:0060124)2.28606173
126Golgi to endosome transport (GO:0006895)2.28601931
127nerve growth factor signaling pathway (GO:0038180)2.27917933
128regulation of neurotransmitter secretion (GO:0046928)2.27830821
129dendrite development (GO:0016358)2.27817242
130regulation of NFAT protein import into nucleus (GO:0051532)2.27733242
131regulation of pigment cell differentiation (GO:0050932)2.27319355
132cerebral cortex radially oriented cell migration (GO:0021799)2.26711720
133neuron projection extension (GO:1990138)2.26114358
134response to auditory stimulus (GO:0010996)2.25932305
135regulation of action potential (GO:0098900)2.25907569
136regulation of dendritic spine development (GO:0060998)2.24796471
137axonogenesis (GO:0007409)2.24282772
138positive regulation of microtubule polymerization (GO:0031116)2.23475927
139suckling behavior (GO:0001967)2.23080373
140mechanosensory behavior (GO:0007638)2.22330105
141postsynaptic membrane organization (GO:0001941)2.22287207
142histone H3-K9 demethylation (GO:0033169)2.22251151
143cell communication by electrical coupling (GO:0010644)2.21602406
144peptidyl-threonine modification (GO:0018210)2.21513162
145prepulse inhibition (GO:0060134)2.21491925
146behavioral defense response (GO:0002209)2.21302056
147behavioral fear response (GO:0001662)2.21302056
148glomerulus development (GO:0032835)2.21095270
149cellular sodium ion homeostasis (GO:0006883)2.19722875
150nucleus localization (GO:0051647)2.19184199
151organelle transport along microtubule (GO:0072384)2.17491622
152neurotransmitter transport (GO:0006836)2.17479232
153central nervous system neuron axonogenesis (GO:0021955)2.17032655
154regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.16813315
155regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.15641577
156regulation of vesicle fusion (GO:0031338)2.15321925
157positive regulation of dendritic spine morphogenesis (GO:0061003)2.12649070
158response to histamine (GO:0034776)2.12328205
159positive regulation of fibroblast migration (GO:0010763)2.09754332
160positive regulation of muscle hypertrophy (GO:0014742)2.08392646
161positive regulation of cardiac muscle hypertrophy (GO:0010613)2.08392646

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67428756
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.56954315
3* GBX2_23144817_ChIP-Seq_PC3_Human2.54139645
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27426335
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26643388
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24246286
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16720364
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16720364
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.16675725
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.05910023
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00772574
12AR_21572438_ChIP-Seq_LNCaP_Human1.88065659
13RNF2_27304074_Chip-Seq_ESCs_Mouse1.84731652
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81739253
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.81422773
16WT1_19549856_ChIP-ChIP_CCG9911_Human1.81162114
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81153084
18* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.80215152
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.80202882
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.80012318
21EZH2_27304074_Chip-Seq_ESCs_Mouse1.78434617
22RARB_27405468_Chip-Seq_BRAIN_Mouse1.77879660
23EWS_26573619_Chip-Seq_HEK293_Human1.77829877
24TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.76267031
25JARID2_20075857_ChIP-Seq_MESCs_Mouse1.74636229
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73815470
27SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65519453
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64225679
29SMAD4_21799915_ChIP-Seq_A2780_Human1.63002370
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.61193368
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59622822
32DROSHA_22980978_ChIP-Seq_HELA_Human1.56739738
33ER_23166858_ChIP-Seq_MCF-7_Human1.56387169
34WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56041248
35REST_21632747_ChIP-Seq_MESCs_Mouse1.55586062
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54961778
37AHR_22903824_ChIP-Seq_MCF-7_Human1.53740790
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.52807239
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51497723
40EED_16625203_ChIP-ChIP_MESCs_Mouse1.50339243
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49744525
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49266710
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.48666466
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.48000196
45VDR_22108803_ChIP-Seq_LS180_Human1.47410125
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.47224301
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46087024
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46030907
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44730781
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44556808
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.44382075
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43866262
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.43333931
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41908867
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41766782
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.41444792
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.41444792
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.41123429
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38982951
60* RXR_22108803_ChIP-Seq_LS180_Human1.38941302
61TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35441140
62TP53_16413492_ChIP-PET_HCT116_Human1.35246378
63* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34649352
64* CBP_20019798_ChIP-Seq_JUKART_Human1.34649352
65P300_19829295_ChIP-Seq_ESCs_Human1.34349654
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.33739523
67TAF15_26573619_Chip-Seq_HEK293_Human1.32684824
68* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32427195
69IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31456114
70STAT3_23295773_ChIP-Seq_U87_Human1.31228285
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.31185390
72AR_25329375_ChIP-Seq_VCAP_Human1.31013861
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.29601927
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29215524
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.29199462
76EZH2_27294783_Chip-Seq_NPCs_Mouse1.28436977
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28251558
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27562460
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26916145
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.26813566
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26571140
82TCF4_18268006_ChIP-ChIP_LS174T_Human1.26355993
83IGF1R_20145208_ChIP-Seq_DFB_Human1.25969713
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25796993
85FUS_26573619_Chip-Seq_HEK293_Human1.25440642
86* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23503737
87* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23018142
88TP53_18474530_ChIP-ChIP_U2OS_Human1.22635888
89KDM2B_26808549_Chip-Seq_K562_Human1.21738739
90P53_22387025_ChIP-Seq_ESCs_Mouse1.21384727
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.21360587
92* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21283744
93DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20921150
94* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20849243
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20793197
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.20623871
97AR_19668381_ChIP-Seq_PC3_Human1.20566469
98* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19941541
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.18598912
100SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18557436
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.18409877
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18362350
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.17914762
104BCAT_22108803_ChIP-Seq_LS180_Human1.17266116
105CMYC_18555785_Chip-Seq_ESCs_Mouse1.17107276
106KDM2B_26808549_Chip-Seq_REH_Human1.16983515
107FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16636129
108RING1B_27294783_Chip-Seq_NPCs_Mouse1.16537628
109* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.16241912
110ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14972291
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14597987
112ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13838213
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13558108
114NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13003967
115TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13002089
116ESR1_20079471_ChIP-ChIP_T-47D_Human1.11721061
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11676148
118P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11626116
119* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11607256
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.11032683
121* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09090525
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.09043282
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08920299
124ZNF274_21170338_ChIP-Seq_K562_Hela1.08115208
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08010021
126STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07828276
127* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07498520
128RNF2_27304074_Chip-Seq_NSC_Mouse1.06091451
129TCF4_23295773_ChIP-Seq_U87_Human1.04825219
130* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.04652329
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04216621
132CBX2_27304074_Chip-Seq_ESCs_Mouse1.03609273
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02628257
134* RUNX2_22187159_ChIP-Seq_PCA_Human1.02382855
135RING1B_27294783_Chip-Seq_ESCs_Mouse1.02258720
136TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.02138288
137TAL1_26923725_Chip-Seq_HPCs_Mouse1.02089058
138EGR1_19374776_ChIP-ChIP_THP-1_Human1.01292136
139PRDM14_20953172_ChIP-Seq_ESCs_Human0.99660356
140POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98981360
141TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98981360
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.96652040

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.49172786
2MP0000569_abnormal_digit_pigmentation3.59763573
3MP0003635_abnormal_synaptic_transmissio3.37964653
4MP0003880_abnormal_central_pattern3.30824035
5MP0003787_abnormal_imprinting3.11478321
6MP0004270_analgesia3.06828814
7MP0001188_hyperpigmentation3.04270064
8MP0002102_abnormal_ear_morphology2.79155979
9MP0002063_abnormal_learning/memory/cond2.64766587
10MP0009745_abnormal_behavioral_response2.40849601
11MP0000778_abnormal_nervous_system2.25525769
12MP0009046_muscle_twitch2.21012002
13MP0002064_seizures2.13872105
14MP0009780_abnormal_chondrocyte_physiolo2.06966915
15MP0002734_abnormal_mechanical_nocicepti2.03393289
16MP0002572_abnormal_emotion/affect_behav1.92769540
17MP0001968_abnormal_touch/_nociception1.89048903
18MP0005187_abnormal_penis_morphology1.88296258
19MP0003221_abnormal_cardiomyocyte_apopto1.83903313
20* MP0001486_abnormal_startle_reflex1.83462697
21MP0003567_abnormal_fetal_cardiomyocyte1.79468180
22MP0005423_abnormal_somatic_nervous1.77671385
23MP0002184_abnormal_innervation1.76914168
24MP0002909_abnormal_adrenal_gland1.62487733
25MP0008569_lethality_at_weaning1.59916492
26* MP0004885_abnormal_endolymph1.52391568
27MP0004811_abnormal_neuron_physiology1.50480833
28MP0001299_abnormal_eye_distance/1.50191200
29MP0005076_abnormal_cell_differentiation1.49722087
30MP0010234_abnormal_vibrissa_follicle1.49040656
31MP0004858_abnormal_nervous_system1.48206157
32MP0002009_preneoplasia1.45338314
33MP0004510_myositis1.43322402
34MP0002272_abnormal_nervous_system1.40873077
35MP0002067_abnormal_sensory_capabilities1.39441624
36MP0001440_abnormal_grooming_behavior1.37275999
37MP0003303_peritoneal_inflammation1.37053641
38MP0005394_taste/olfaction_phenotype1.37024320
39MP0005499_abnormal_olfactory_system1.37024320
40MP0004084_abnormal_cardiac_muscle1.35439086
41MP0001984_abnormal_olfaction1.34596437
42MP0002736_abnormal_nociception_after1.34557414
43MP0001501_abnormal_sleep_pattern1.32946577
44MP0001348_abnormal_lacrimal_gland1.32762198
45MP0005623_abnormal_meninges_morphology1.32461152
46MP0003879_abnormal_hair_cell1.31154336
47MP0002557_abnormal_social/conspecific_i1.26463259
48MP0002877_abnormal_melanocyte_morpholog1.22952683
49MP0005174_abnormal_tail_pigmentation1.21687248
50MP0000534_abnormal_ureter_morphology1.20813730
51MP0001970_abnormal_pain_threshold1.20225358
52MP0003121_genomic_imprinting1.20139781
53MP0005248_abnormal_Harderian_gland1.19874237
54MP0002837_dystrophic_cardiac_calcinosis1.19568741
55MP0003300_gastrointestinal_ulcer1.19319500
56MP0000955_abnormal_spinal_cord1.18600513
57MP0002733_abnormal_thermal_nociception1.18072400
58MP0004142_abnormal_muscle_tone1.15073185
59MP0001177_atelectasis1.14777244
60MP0003122_maternal_imprinting1.14319213
61MP0004924_abnormal_behavior1.13576333
62MP0005386_behavior/neurological_phenoty1.13576333
63MP0000427_abnormal_hair_cycle1.12405716
64MP0003890_abnormal_embryonic-extraembry1.11862393
65MP0002882_abnormal_neuron_morphology1.11735638
66MP0002152_abnormal_brain_morphology1.09670481
67MP0002751_abnormal_autonomic_nervous1.07600821
68MP0002735_abnormal_chemical_nociception1.06763216
69MP0003385_abnormal_body_wall1.06673136
70MP0001502_abnormal_circadian_rhythm1.06071014
71MP0003705_abnormal_hypodermis_morpholog1.02735461
72MP0008789_abnormal_olfactory_epithelium1.01617292
73MP0005409_darkened_coat_color1.00601460
74MP0003937_abnormal_limbs/digits/tail_de0.99895241
75MP0001286_abnormal_eye_development0.98994294
76MP0002066_abnormal_motor_capabilities/c0.97377926
77MP0005645_abnormal_hypothalamus_physiol0.95924395
78MP0003943_abnormal_hepatobiliary_system0.94379689
79MP0003633_abnormal_nervous_system0.93803768
80MP0003091_abnormal_cell_migration0.93698550
81MP0005167_abnormal_blood-brain_barrier0.92543692
82MP0000428_abnormal_craniofacial_morphol0.92192714
83MP0009703_decreased_birth_body0.91667337
84MP0003123_paternal_imprinting0.89846453
85MP0003861_abnormal_nervous_system0.89658296
86MP0005646_abnormal_pituitary_gland0.88799741
87MP0000631_abnormal_neuroendocrine_gland0.86854587
88MP0006292_abnormal_olfactory_placode0.86283014
89MP0003115_abnormal_respiratory_system0.85572763
90MP0009053_abnormal_anal_canal0.84764203
91MP0003942_abnormal_urinary_system0.83955127
92* MP0000049_abnormal_middle_ear0.83868018
93MP0010386_abnormal_urinary_bladder0.83627911
94MP0003119_abnormal_digestive_system0.82694748
95MP0006276_abnormal_autonomic_nervous0.82518994
96MP0002233_abnormal_nose_morphology0.82467770
97MP0009250_abnormal_appendicular_skeleto0.81754312
98MP0000537_abnormal_urethra_morphology0.80798094
99* MP0003755_abnormal_palate_morphology0.80157105
100MP0002234_abnormal_pharynx_morphology0.78919517
101MP0004145_abnormal_muscle_electrophysio0.78686903
102MP0001879_abnormal_lymphatic_vessel0.78193918
103MP0004883_abnormal_blood_vessel0.78191633
104MP0005551_abnormal_eye_electrophysiolog0.77858386
105MP0002752_abnormal_somatic_nervous0.77621428
106MP0002638_abnormal_pupillary_reflex0.77162090
107MP0004133_heterotaxia0.75981573
108MP0000383_abnormal_hair_follicle0.75804475
109MP0004215_abnormal_myocardial_fiber0.74455257
110MP0000516_abnormal_urinary_system0.73537804
111MP0005367_renal/urinary_system_phenotyp0.73537804
112MP0004197_abnormal_fetal_growth/weight/0.73536840
113MP0003631_nervous_system_phenotype0.73530539
114MP0003938_abnormal_ear_development0.72673099
115MP0006138_congestive_heart_failure0.71834215
116MP0003935_abnormal_craniofacial_develop0.71653401
117MP0004742_abnormal_vestibular_system0.71424267
118MP0000013_abnormal_adipose_tissue0.71129938
119MP0010368_abnormal_lymphatic_system0.70196428
120MP0001529_abnormal_vocalization0.69910035
121MP0005388_respiratory_system_phenotype0.69532973
122MP0002133_abnormal_respiratory_system0.69532973
123MP0002896_abnormal_bone_mineralization0.69013144
124MP0008877_abnormal_DNA_methylation0.69000950
125MP0000733_abnormal_muscle_development0.68467155
126MP0004484_altered_response_of0.65755114
127MP0004130_abnormal_muscle_cell0.65076609
128* MP0002081_perinatal_lethality0.64266106
129MP0008961_abnormal_basal_metabolism0.64014402
130MP0002163_abnormal_gland_morphology0.63901716
131MP0001943_abnormal_respiration0.61820547
132MP0002168_other_aberrant_phenotype0.61218082
133MP0009384_cardiac_valve_regurgitation0.59241535
134MP0002069_abnormal_eating/drinking_beha0.58493558

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.70263699
2Focal seizures (HP:0007359)3.47418328
3Visual hallucinations (HP:0002367)3.31309625
4Febrile seizures (HP:0002373)3.02742940
5Papillary thyroid carcinoma (HP:0002895)2.99456003
6Genetic anticipation (HP:0003743)2.95999108
7Myokymia (HP:0002411)2.89455262
8Broad-based gait (HP:0002136)2.88638064
9Atonic seizures (HP:0010819)2.86622531
10Progressive cerebellar ataxia (HP:0002073)2.82148851
11Fair hair (HP:0002286)2.74442017
12Limb dystonia (HP:0002451)2.73615702
13Epileptic encephalopathy (HP:0200134)2.69204039
14Intestinal atresia (HP:0011100)2.61728700
15Long clavicles (HP:0000890)2.58252084
16Drooling (HP:0002307)2.55257308
17Excessive salivation (HP:0003781)2.55257308
18Inappropriate behavior (HP:0000719)2.54149570
19Action tremor (HP:0002345)2.52404490
20Absence seizures (HP:0002121)2.46198730
21Protruding tongue (HP:0010808)2.37321374
22Gaze-evoked nystagmus (HP:0000640)2.37076562
23Morphological abnormality of the middle ear (HP:0008609)2.34730418
24Aplasia/Hypoplasia of the sternum (HP:0006714)2.31871040
25Abnormal hair whorl (HP:0010721)2.31434984
26Hip dysplasia (HP:0001385)2.29670987
27Truncal ataxia (HP:0002078)2.27141839
28Subacute progressive viral hepatitis (HP:0006572)2.26307027
29Papilledema (HP:0001085)2.25124715
30Vertebral arch anomaly (HP:0008438)2.24910188
31Abnormality of the corticospinal tract (HP:0002492)2.18800825
32Abnormality of the ischium (HP:0003174)2.17206114
33Truncal obesity (HP:0001956)2.16346615
34Macroorchidism (HP:0000053)2.15597979
35Shallow orbits (HP:0000586)2.13972756
36Degeneration of the lateral corticospinal tracts (HP:0002314)2.12965119
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.12965119
38Mutism (HP:0002300)2.12442867
39Absent frontal sinuses (HP:0002688)2.12333053
40Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.10400043
41Short 4th metacarpal (HP:0010044)2.10400043
42Nephronophthisis (HP:0000090)2.10334359
43Curly hair (HP:0002212)2.09164177
44Subaortic stenosis (HP:0001682)2.09049993
45Abnormality of the left ventricular outflow tract (HP:0011103)2.09049993
46Generalized tonic-clonic seizures (HP:0002069)2.09005895
47Aqueductal stenosis (HP:0002410)2.05581793
48Dialeptic seizures (HP:0011146)2.05567402
49True hermaphroditism (HP:0010459)2.05349776
50Agitation (HP:0000713)2.03977574
51Hemiplegia (HP:0002301)2.03848585
52Dysmetric saccades (HP:0000641)2.03773859
53Generalized hypopigmentation of hair (HP:0011358)2.02308114
54Absent eyebrow (HP:0002223)2.01743141
55Narrow forehead (HP:0000341)2.00752625
56Urinary bladder sphincter dysfunction (HP:0002839)2.00362373
57Enlarged penis (HP:0000040)2.00212031
58Gait imbalance (HP:0002141)1.99996808
59Chronic hepatic failure (HP:0100626)1.98870941
60Acute lymphatic leukemia (HP:0006721)1.98829658
61Transitional cell carcinoma of the bladder (HP:0006740)1.98261881
62Megalencephaly (HP:0001355)1.97921685
63Abnormality of the musculature of the pelvis (HP:0001469)1.97539593
64Abnormality of the hip-girdle musculature (HP:0001445)1.97539593
65Gonadotropin excess (HP:0000837)1.96792420
66Genital tract atresia (HP:0001827)1.96356943
67Amyotrophic lateral sclerosis (HP:0007354)1.95940420
68Epidermoid cyst (HP:0200040)1.95521817
69Impaired smooth pursuit (HP:0007772)1.94268011
70Abnormality of the pubic bones (HP:0003172)1.93782150
71Abnormal lung lobation (HP:0002101)1.93391671
72Oligodontia (HP:0000677)1.92412165
73Abnormality of the renal medulla (HP:0100957)1.90982986
74Depression (HP:0000716)1.90217812
75Hypoplastic nipples (HP:0002557)1.88645341
76Hemiparesis (HP:0001269)1.88402531
77Facial hemangioma (HP:0000329)1.88372949
78Lower limb asymmetry (HP:0100559)1.86634853
79Narrow palate (HP:0000189)1.86428689
80Renal hypoplasia (HP:0000089)1.86385816
81Vaginal atresia (HP:0000148)1.86364069
82Thyroid carcinoma (HP:0002890)1.86318824
83Pelvic girdle muscle weakness (HP:0003749)1.84898397
84Bladder neoplasm (HP:0009725)1.82587095
85Bladder carcinoma (HP:0002862)1.82587095
86Stereotypic behavior (HP:0000733)1.82053519
87Cubitus valgus (HP:0002967)1.81821563
88Difficulty running (HP:0009046)1.80857368
89Hepatoblastoma (HP:0002884)1.80742523
90Amblyopia (HP:0000646)1.80037584
91Overgrowth (HP:0001548)1.79091670
92Neoplasm of the oral cavity (HP:0100649)1.78765541
93Dysdiadochokinesis (HP:0002075)1.78184980
94Exotropia (HP:0000577)1.76716137
95Neoplasm of the adrenal cortex (HP:0100641)1.76623219
96Arterial tortuosity (HP:0005116)1.76325268
97Pointed chin (HP:0000307)1.76145493
98Termporal pattern (HP:0011008)1.75251193
99Insidious onset (HP:0003587)1.75251193
100Lower limb muscle weakness (HP:0007340)1.74972158
101Impaired vibration sensation in the lower limbs (HP:0002166)1.74552410
102Progressive inability to walk (HP:0002505)1.74282433
103Nephroblastoma (Wilms tumor) (HP:0002667)1.73658540
104Embryonal renal neoplasm (HP:0011794)1.73103860
105Diplopia (HP:0000651)1.70350284
106Abnormality of binocular vision (HP:0011514)1.70350284
107Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.70317259
108Congenital primary aphakia (HP:0007707)1.69939034
109Viral hepatitis (HP:0006562)1.69622771
110Supranuclear gaze palsy (HP:0000605)1.69416668
111Skull defect (HP:0001362)1.69296862
112Abnormality of ocular smooth pursuit (HP:0000617)1.68992273
113Abnormality of salivation (HP:0100755)1.68423633
114Abnormality of the nasal septum (HP:0000419)1.68381321
115Syringomyelia (HP:0003396)1.68304278
116Spinal cord lesions (HP:0100561)1.68304278
117Obstructive sleep apnea (HP:0002870)1.67543787
118Rectal prolapse (HP:0002035)1.67182734
119Asymmetry of the thorax (HP:0001555)1.66869660
120Cutaneous finger syndactyly (HP:0010554)1.66472004
121Complete atrioventricular canal defect (HP:0001674)1.66448799
122Abnormality of the labia minora (HP:0012880)1.65864110
123Thickened helices (HP:0000391)1.65403939
124Microglossia (HP:0000171)1.65304026
125Short foot (HP:0001773)1.65051962
126Absent speech (HP:0001344)1.64815709
127Gastroesophageal reflux (HP:0002020)1.63908041
128Medial flaring of the eyebrow (HP:0010747)1.63688913
129Germ cell neoplasia (HP:0100728)1.63600987
130Cupped ear (HP:0000378)1.63599293
131Growth hormone deficiency (HP:0000824)1.63562777
132Apathy (HP:0000741)1.63413308
133Disinhibition (HP:0000734)1.62936772
134Biliary tract neoplasm (HP:0100574)1.62930623
135Epileptiform EEG discharges (HP:0011182)1.62618523
136Abnormality of the 4th metacarpal (HP:0010012)1.62240266
137Optic nerve hypoplasia (HP:0000609)1.61309931
138Urinary urgency (HP:0000012)1.61053961
139Postaxial hand polydactyly (HP:0001162)1.60572024
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.59644373
141Cystic hygroma (HP:0000476)1.58389594
142Hyperventilation (HP:0002883)1.58017917
143Sporadic (HP:0003745)1.57835375
144Open mouth (HP:0000194)1.57514422
145Trigonocephaly (HP:0000243)1.56986992
146Ankle clonus (HP:0011448)1.56895435
147Widely spaced teeth (HP:0000687)1.56721997
148Fetal akinesia sequence (HP:0001989)1.56442303
149Uterine leiomyosarcoma (HP:0002891)1.55117652
150Leiomyosarcoma (HP:0100243)1.55117652
151Heterotopia (HP:0002282)1.54982346
152Volvulus (HP:0002580)1.54547805
153Vascular tortuosity (HP:0004948)1.54388123
154Ankyloglossia (HP:0010296)1.54271389
155Thick eyebrow (HP:0000574)1.53343366
156Deeply set eye (HP:0000490)1.52514537
157Shoulder girdle muscle weakness (HP:0003547)1.51868508
158Poor eye contact (HP:0000817)1.51589339
159Impaired social interactions (HP:0000735)1.51284953

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.44893850
2BCR3.41198654
3LATS13.03036221
4NTRK32.96929774
5MAP3K42.96221523
6MARK12.91360276
7MAP3K92.77942978
8TRIM282.69383251
9EPHA42.66715211
10KSR12.43727625
11KSR22.41916593
12LATS22.33140372
13PAK62.24519750
14MAP2K72.21217822
15BRD42.06489450
16MINK11.88609219
17DAPK21.82371427
18PLK21.78684433
19RIPK41.78216545
20PRKD31.65381105
21NTRK21.64114016
22SIK21.60778098
23ERBB31.56696898
24CAMKK11.55047365
25MAP2K41.50078262
26TAOK11.49740868
27WNK31.46697606
28MAP3K21.46392581
29RPS6KA41.43933538
30SGK31.42380991
31SGK21.41727250
32LMTK21.39320827
33STK381.37321311
34MAPK131.25949796
35BMPR1B1.23208846
36TYRO31.21783523
37MKNK11.21032077
38CAMK1G1.16587006
39CDK121.16186854
40CDK51.14442588
41RET1.11487492
42FGFR31.09260082
43RAF11.06355686
44STK38L1.03485396
45CASK1.03428735
46SIK31.00884726
47FRK0.99540800
48PNCK0.98327208
49PKN10.96367873
50BRSK20.95318196
51MAP3K120.94817165
52PDGFRA0.92779534
53CDK30.92669817
54DYRK30.91788803
55PAK30.90837979
56STK110.90653329
57SGK2230.90441683
58SGK4940.90441683
59FGFR20.90047000
60BMPR20.88548096
61CAMKK20.88368080
62MAP3K60.88086824
63PRPF4B0.87108034
64PINK10.86188045
65RIPK10.85708440
66PRKCH0.85451929
67NLK0.84049473
68SGK10.83940615
69ALK0.81823790
70NUAK10.81529313
71NTRK10.80605735
72EPHA30.80083508
73DYRK1A0.79571555
74PDGFRB0.78956953
75DAPK10.75372982
76PRKCE0.73754444
77DDR20.72873703
78MAPK100.71777279
79STK240.71616946
80CSNK1G20.70596705
81WEE10.69875187
82ERBB20.69502096
83MARK20.69210639
84DMPK0.68703412
85OXSR10.67293233
86FER0.67022410
87MAP3K130.66721129
88CDC42BPA0.66610759
89UHMK10.66050326
90CDK60.65321781
91PRKCG0.64351289
92TRIB30.63825885
93PKN20.61952756
94FES0.61268836
95MAP3K70.59241455
96STK30.59111894
97IRAK10.57856300
98EPHB20.57227399
99SCYL20.56496076
100CDK190.56278752
101TIE10.55279442
102WNK10.54052450
103CSNK1A1L0.52001221
104STK390.51354318
105PHKG20.50287548
106PHKG10.50287548
107MKNK20.50200650
108PIK3CA0.49132972
109MAP3K50.48384514
110NEK90.48148118
111CAMK40.47497496
112PRKAA10.46917418
113MAPK80.46888992
114HCK0.46746960
115CAMK1D0.46610680
116CAMK2A0.46594865
117RPS6KB10.46464570
118AKT30.45659498
119MAP4K20.45328268
120TGFBR10.44867132
121CAMK2B0.44512434
122FGFR10.42948641
123RPS6KA30.42867171
124GRK50.41957459
125PRKG10.41847027
126YES10.40797067
127TAOK30.40795341
128DYRK1B0.40711311
129CAMK10.39888797
130MAP3K10.39585753
131PLK30.39310940
132CDK90.37451865
133PDK10.37212597
134ACVR1B0.37000989
135MAP3K100.36547114
136JAK10.36209801
137BMX0.36167812
138NEK60.35587556
139DYRK20.34462098
140CSNK1D0.33879560
141CSNK1E0.33831778
142CSNK1G10.33703269

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.23085846
2Long-term potentiation_Homo sapiens_hsa047202.10127738
3Synaptic vesicle cycle_Homo sapiens_hsa047212.04203285
4Olfactory transduction_Homo sapiens_hsa047402.03046308
5Circadian entrainment_Homo sapiens_hsa047131.73095773
6Glutamatergic synapse_Homo sapiens_hsa047241.70262105
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67462435
8GABAergic synapse_Homo sapiens_hsa047271.57395335
9Morphine addiction_Homo sapiens_hsa050321.54007911
10Amphetamine addiction_Homo sapiens_hsa050311.53755459
11Dopaminergic synapse_Homo sapiens_hsa047281.51055105
12Cholinergic synapse_Homo sapiens_hsa047251.45567618
13Glioma_Homo sapiens_hsa052141.41404757
14Dorso-ventral axis formation_Homo sapiens_hsa043201.41326538
15Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38668427
16GnRH signaling pathway_Homo sapiens_hsa049121.36621515
17Renin secretion_Homo sapiens_hsa049241.36225511
18Long-term depression_Homo sapiens_hsa047301.36159975
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34665667
20Oxytocin signaling pathway_Homo sapiens_hsa049211.33415358
21Gastric acid secretion_Homo sapiens_hsa049711.31325848
22Type II diabetes mellitus_Homo sapiens_hsa049301.31133263
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30532342
24Salivary secretion_Homo sapiens_hsa049701.28189605
25ErbB signaling pathway_Homo sapiens_hsa040121.26560698
26Insulin secretion_Homo sapiens_hsa049111.23835359
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19532835
28Estrogen signaling pathway_Homo sapiens_hsa049151.17302371
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.17130654
30Axon guidance_Homo sapiens_hsa043601.15313479
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14893416
32Endometrial cancer_Homo sapiens_hsa052131.14495754
33Colorectal cancer_Homo sapiens_hsa052101.13958528
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12684477
35Renal cell carcinoma_Homo sapiens_hsa052111.10216438
36cAMP signaling pathway_Homo sapiens_hsa040241.09356706
37mTOR signaling pathway_Homo sapiens_hsa041501.08192514
38Phototransduction_Homo sapiens_hsa047441.07266357
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.05832642
40Cocaine addiction_Homo sapiens_hsa050301.05000732
41Gap junction_Homo sapiens_hsa045401.04365540
42Hedgehog signaling pathway_Homo sapiens_hsa043401.01062897
43Serotonergic synapse_Homo sapiens_hsa047260.99828750
44mRNA surveillance pathway_Homo sapiens_hsa030150.99682282
45Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97549088
46cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96946427
47MAPK signaling pathway_Homo sapiens_hsa040100.96201681
48Chronic myeloid leukemia_Homo sapiens_hsa052200.93981308
49Melanogenesis_Homo sapiens_hsa049160.93820813
50Taste transduction_Homo sapiens_hsa047420.92596258
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92489808
52Type I diabetes mellitus_Homo sapiens_hsa049400.90930019
53Non-small cell lung cancer_Homo sapiens_hsa052230.90595554
54Prolactin signaling pathway_Homo sapiens_hsa049170.90575405
55Pancreatic cancer_Homo sapiens_hsa052120.89982716
56Calcium signaling pathway_Homo sapiens_hsa040200.89750015
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89310043
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87834923
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.87558314
60Choline metabolism in cancer_Homo sapiens_hsa052310.87273011
61VEGF signaling pathway_Homo sapiens_hsa043700.86366431
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86058915
63Inositol phosphate metabolism_Homo sapiens_hsa005620.85915995
64TGF-beta signaling pathway_Homo sapiens_hsa043500.85912968
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85620834
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85053383
67Oocyte meiosis_Homo sapiens_hsa041140.82577239
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.82439268
69Adherens junction_Homo sapiens_hsa045200.81062038
70Chemokine signaling pathway_Homo sapiens_hsa040620.80565569
71Regulation of autophagy_Homo sapiens_hsa041400.79792070
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79643474
73FoxO signaling pathway_Homo sapiens_hsa040680.79254638
74MicroRNAs in cancer_Homo sapiens_hsa052060.78368488
75Wnt signaling pathway_Homo sapiens_hsa043100.77781938
76Proteoglycans in cancer_Homo sapiens_hsa052050.76334441
77Circadian rhythm_Homo sapiens_hsa047100.75488491
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74813161
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74719521
80Ras signaling pathway_Homo sapiens_hsa040140.73572575
81T cell receptor signaling pathway_Homo sapiens_hsa046600.73474837
82Rap1 signaling pathway_Homo sapiens_hsa040150.73155423
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72444686
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71608391
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70684540
86Osteoclast differentiation_Homo sapiens_hsa043800.69621726
87Dilated cardiomyopathy_Homo sapiens_hsa054140.69574539
88Prostate cancer_Homo sapiens_hsa052150.69382931
89Focal adhesion_Homo sapiens_hsa045100.69238158
90B cell receptor signaling pathway_Homo sapiens_hsa046620.69156127
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.68662670
92Thyroid hormone synthesis_Homo sapiens_hsa049180.68618099
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.67921504
94Hippo signaling pathway_Homo sapiens_hsa043900.67226786
95Tuberculosis_Homo sapiens_hsa051520.67220635
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66562077
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65811972
98Basal transcription factors_Homo sapiens_hsa030220.65571617
99Pancreatic secretion_Homo sapiens_hsa049720.65200100
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62774201
101Insulin signaling pathway_Homo sapiens_hsa049100.62359522
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62217266
103TNF signaling pathway_Homo sapiens_hsa046680.62147193
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62136188
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.61692385
106Platelet activation_Homo sapiens_hsa046110.60298058
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60282297
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59997368
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59969590
110Melanoma_Homo sapiens_hsa052180.59844895
111Endocytosis_Homo sapiens_hsa041440.59583960
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58984132
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58730190
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58687538
115Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58454575
116Tight junction_Homo sapiens_hsa045300.57534766
117Basal cell carcinoma_Homo sapiens_hsa052170.56074018
118Protein export_Homo sapiens_hsa030600.54997989
119AMPK signaling pathway_Homo sapiens_hsa041520.54614694
120Glucagon signaling pathway_Homo sapiens_hsa049220.52658284
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50950132
122Ether lipid metabolism_Homo sapiens_hsa005650.50227837
123Lysine degradation_Homo sapiens_hsa003100.49559794
124Pathways in cancer_Homo sapiens_hsa052000.46454620

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