FBXO15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)6.88218042
2nucleobase biosynthetic process (GO:0046112)6.11268124
3ribosome assembly (GO:0042255)6.02911240
4mitotic metaphase plate congression (GO:0007080)5.83687639
5indole-containing compound catabolic process (GO:0042436)5.78295575
6indolalkylamine catabolic process (GO:0046218)5.78295575
7tryptophan catabolic process (GO:0006569)5.78295575
8cilium or flagellum-dependent cell motility (GO:0001539)5.75823051
9vitamin transmembrane transport (GO:0035461)5.41868803
10kynurenine metabolic process (GO:0070189)5.33037730
11regulation of spindle organization (GO:0090224)5.24714868
12indolalkylamine metabolic process (GO:0006586)5.20431558
13folic acid metabolic process (GO:0046655)5.06064776
14ribosome biogenesis (GO:0042254)5.04898883
15DNA replication checkpoint (GO:0000076)4.91701416
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.90443293
17tryptophan metabolic process (GO:0006568)4.81155954
18detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.69047403
19signal peptide processing (GO:0006465)4.66333209
20formation of translation preinitiation complex (GO:0001731)4.62319211
21transcription elongation from RNA polymerase I promoter (GO:0006362)4.50658067
22folic acid transport (GO:0015884)4.50205529
23termination of RNA polymerase I transcription (GO:0006363)4.46933844
24metaphase plate congression (GO:0051310)4.41823991
25rRNA modification (GO:0000154)4.41802833
26regulation of establishment of cell polarity (GO:2000114)4.35753247
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.35673349
28positive regulation of chromosome segregation (GO:0051984)4.31613813
29neural tube formation (GO:0001841)4.31584483
30termination of RNA polymerase III transcription (GO:0006386)4.29717294
31transcription elongation from RNA polymerase III promoter (GO:0006385)4.29717294
32regulation of mitotic spindle organization (GO:0060236)4.22373607
33monoubiquitinated protein deubiquitination (GO:0035520)4.21262285
34transcription from RNA polymerase I promoter (GO:0006360)4.19805613
35GMP metabolic process (GO:0046037)4.15102916
36protein localization to kinetochore (GO:0034501)4.06957337
37lung-associated mesenchyme development (GO:0060484)4.04356963
38detection of light stimulus involved in visual perception (GO:0050908)4.02556824
39detection of light stimulus involved in sensory perception (GO:0050962)4.02556824
40maturation of SSU-rRNA (GO:0030490)4.02280233
41transcription initiation from RNA polymerase I promoter (GO:0006361)4.02057089
42protein K11-linked deubiquitination (GO:0035871)3.97623265
437-methylguanosine mRNA capping (GO:0006370)3.95490431
44blastocyst development (GO:0001824)3.90763867
45proteasome assembly (GO:0043248)3.90225164
46glycine metabolic process (GO:0006544)3.89422585
47RNA capping (GO:0036260)3.82808360
487-methylguanosine RNA capping (GO:0009452)3.82808360
49photoreceptor cell maintenance (GO:0045494)3.81830638
50indole-containing compound metabolic process (GO:0042430)3.80864864
51anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.80414323
52ribonucleoprotein complex biogenesis (GO:0022613)3.79569910
53regulation of hippo signaling (GO:0035330)3.78568952
54regulation of establishment or maintenance of cell polarity (GO:0032878)3.78397149
55regulation of translation in response to stress (GO:0043555)3.78065747
56positive regulation of developmental pigmentation (GO:0048087)3.75986757
57histone-serine phosphorylation (GO:0035404)3.75660696
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.74149052
59protein K48-linked deubiquitination (GO:0071108)3.70756108
60mitotic nuclear envelope disassembly (GO:0007077)3.69706099
61tachykinin receptor signaling pathway (GO:0007217)3.68302773
62rRNA processing (GO:0006364)3.66239057
63establishment of protein localization to Golgi (GO:0072600)3.65622508
64spindle checkpoint (GO:0031577)3.65155704
65regulation of posttranscriptional gene silencing (GO:0060147)3.63599286
66regulation of gene silencing by miRNA (GO:0060964)3.63599286
67regulation of gene silencing by RNA (GO:0060966)3.63599286
68regulation of sarcomere organization (GO:0060297)3.62823219
69cellular ketone body metabolic process (GO:0046950)3.62354734
70cilium movement (GO:0003341)3.62337800
71positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.62153164
72sex differentiation (GO:0007548)3.61438885
73reflex (GO:0060004)3.61067123
74regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.61008121
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.60153293
76regulation of pigment cell differentiation (GO:0050932)3.58984157
77rRNA methylation (GO:0031167)3.58512573
78rRNA metabolic process (GO:0016072)3.56834691
79cellular biogenic amine catabolic process (GO:0042402)3.54996590
80amine catabolic process (GO:0009310)3.54996590
81spliceosomal snRNP assembly (GO:0000387)3.54310550
82phospholipid translocation (GO:0045332)3.53889256
83lipid translocation (GO:0034204)3.53889256
84intestinal epithelial cell development (GO:0060576)3.53713517
85mitotic spindle checkpoint (GO:0071174)3.53577182
86serine family amino acid catabolic process (GO:0009071)3.53195215
87regulation of G0 to G1 transition (GO:0070316)3.52722244
88regulation of chromosome segregation (GO:0051983)3.52137382
89benzene-containing compound metabolic process (GO:0042537)3.45970335
90nuclear envelope disassembly (GO:0051081)3.45767804
91membrane disassembly (GO:0030397)3.45767804
92maturation of 5.8S rRNA (GO:0000460)3.45593788
93pantothenate metabolic process (GO:0015939)3.45366965
94NAD biosynthetic process (GO:0009435)3.44635709
95behavioral response to ethanol (GO:0048149)3.43795663
96snRNA transcription (GO:0009301)3.43403170
97protein localization to chromosome, centromeric region (GO:0071459)3.42848166
98regulation of memory T cell differentiation (GO:0043380)3.40615523
99negative regulation of chromosome segregation (GO:0051985)3.39943799
100auditory receptor cell stereocilium organization (GO:0060088)3.39699958
101L-methionine salvage (GO:0071267)3.39271250
102L-methionine biosynthetic process (GO:0071265)3.39271250
103amino acid salvage (GO:0043102)3.39271250
104DNA-templated transcription, elongation (GO:0006354)3.39024809
105attachment of spindle microtubules to kinetochore (GO:0008608)3.38750047
106establishment of chromosome localization (GO:0051303)3.37997975
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.37809915
108interkinetic nuclear migration (GO:0022027)3.36879154
109negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.35730769
110DNA replication initiation (GO:0006270)3.35197765
111negative regulation of mitotic sister chromatid separation (GO:2000816)3.33131518
112negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33131518
113negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33131518
114negative regulation of sister chromatid segregation (GO:0033046)3.33131518
115mitotic spindle assembly checkpoint (GO:0007094)3.32086646
116gamma-aminobutyric acid transport (GO:0015812)3.30060922
117negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30030569
118transcription elongation from RNA polymerase II promoter (GO:0006368)3.29490612
119regulation of mitotic metaphase/anaphase transition (GO:0030071)3.26286155
120axoneme assembly (GO:0035082)3.25708339
121CENP-A containing nucleosome assembly (GO:0034080)3.25675167
122aromatic amino acid family catabolic process (GO:0009074)3.25419553
123ketone body metabolic process (GO:1902224)3.24523114
124spindle assembly checkpoint (GO:0071173)3.24464096
125autophagic vacuole assembly (GO:0000045)3.24428370
126protein K63-linked deubiquitination (GO:0070536)3.23260555
127negative regulation of mast cell activation (GO:0033004)3.23086216
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22926250
129cytoplasmic mRNA processing body assembly (GO:0033962)3.22496633
130L-fucose catabolic process (GO:0042355)3.21947247
131fucose catabolic process (GO:0019317)3.21947247
132L-fucose metabolic process (GO:0042354)3.21947247
133serotonin metabolic process (GO:0042428)3.21697837
134protein K6-linked ubiquitination (GO:0085020)3.20245342
135negative regulation of calcium ion transport into cytosol (GO:0010523)3.19452130
136regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18555842
137positive regulation of viral transcription (GO:0050434)3.17932242
138methionine metabolic process (GO:0006555)3.17616825
139nuclear envelope organization (GO:0006998)3.17229816
140guanosine-containing compound biosynthetic process (GO:1901070)3.16688519
141sphingoid metabolic process (GO:0046519)3.15759528
142positive regulation of ligase activity (GO:0051351)3.15104062
143central nervous system neuron axonogenesis (GO:0021955)3.14899018
144mitotic sister chromatid segregation (GO:0000070)3.14033501
145detection of mechanical stimulus involved in sensory perception (GO:0050974)3.13811969
146nuclear pore organization (GO:0006999)3.13606823
147behavioral response to nicotine (GO:0035095)3.13026555
148thyroid hormone metabolic process (GO:0042403)3.12792411
149DNA replication-independent nucleosome assembly (GO:0006336)3.11509043
150DNA replication-independent nucleosome organization (GO:0034724)3.11509043
151modified amino acid transport (GO:0072337)3.08409507
152piRNA metabolic process (GO:0034587)3.07136938
153regulation of exit from mitosis (GO:0007096)3.06448889
154regulation of centrosome cycle (GO:0046605)3.06308965
155NADH metabolic process (GO:0006734)3.05797675
156methionine biosynthetic process (GO:0009086)3.05568186
157chromatin remodeling at centromere (GO:0031055)3.05551799
158epithelial cilium movement (GO:0003351)3.05108828
159protein localization to chromosome (GO:0034502)3.04781704
160UDP-N-acetylglucosamine metabolic process (GO:0006047)3.03970338
161meiosis I (GO:0007127)3.03189219
162ribosomal large subunit biogenesis (GO:0042273)3.03171422
163flavonoid metabolic process (GO:0009812)3.02977982
164regulation of double-strand break repair via homologous recombination (GO:0010569)3.02828560
165histone exchange (GO:0043486)3.02577626
166regulation of nuclear cell cycle DNA replication (GO:0033262)3.01371165
167primary amino compound metabolic process (GO:1901160)3.00906594
168cellular response to sterol (GO:0036315)2.98890965
169oxidative demethylation (GO:0070989)2.96788564
170negative regulation of multicellular organism growth (GO:0040015)2.96232512
171DNA methylation involved in gamete generation (GO:0043046)2.95622921
172aromatic amino acid family metabolic process (GO:0009072)2.93275982
173positive regulation of vasculogenesis (GO:2001214)2.88059494
174regulation of MHC class I biosynthetic process (GO:0045343)2.85761852
175inner ear receptor stereocilium organization (GO:0060122)2.82818597
176righting reflex (GO:0060013)2.82393235
177G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81035482
178neuronal action potential propagation (GO:0019227)2.77452277
179retinal cone cell development (GO:0046549)2.76732823
180sulfation (GO:0051923)2.74370437
181one-carbon compound transport (GO:0019755)2.74159815
182L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.73908406
183cilium organization (GO:0044782)2.72814494
184central nervous system projection neuron axonogenesis (GO:0021952)2.72350466
185positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.71888350
186axonemal dynein complex assembly (GO:0070286)2.70029268
187cilium assembly (GO:0042384)2.69072553
188regulation of collateral sprouting (GO:0048670)2.68828793
189drug catabolic process (GO:0042737)2.68430144
190cerebellar Purkinje cell differentiation (GO:0021702)2.65481543
191cilium morphogenesis (GO:0060271)2.63833341
192membrane depolarization during action potential (GO:0086010)2.63128403
193protein localization to cilium (GO:0061512)2.59676006
194left/right axis specification (GO:0070986)2.56509778
195limb development (GO:0060173)2.55579132
196appendage development (GO:0048736)2.55579132
197neuronal action potential (GO:0019228)2.55064090
198acrosome assembly (GO:0001675)2.53628128
199regulation of action potential (GO:0098900)2.52307933
200ADP metabolic process (GO:0046031)2.51835573

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.09911478
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.47192881
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.02024434
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.85173593
5GBX2_23144817_ChIP-Seq_PC3_Human3.63515424
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.59378967
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.54933683
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.51973586
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.43415206
10VDR_22108803_ChIP-Seq_LS180_Human3.23000203
11* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.19951595
12GABP_17652178_ChIP-ChIP_JURKAT_Human3.18285312
13EST1_17652178_ChIP-ChIP_JURKAT_Human3.06376144
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00376768
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.92913006
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.86844249
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83989695
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80922417
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79343200
20IGF1R_20145208_ChIP-Seq_DFB_Human2.76698020
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.74385975
22AR_21909140_ChIP-Seq_LNCAP_Human2.70694177
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.62493659
24EZH2_22144423_ChIP-Seq_EOC_Human2.59634659
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.59134971
26ZNF274_21170338_ChIP-Seq_K562_Hela2.52810445
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.50724231
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.50151521
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.40905202
30* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.40480055
31VDR_23849224_ChIP-Seq_CD4+_Human2.39066279
32TAF15_26573619_Chip-Seq_HEK293_Human2.37532667
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25052729
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.17969608
35XRN2_22483619_ChIP-Seq_HELA_Human2.16280289
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.14427482
37* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.13805695
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.12819602
39* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.10588185
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.05820223
41* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05802623
42* GABP_19822575_ChIP-Seq_HepG2_Human2.05438916
43* POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.04031586
44ZNF263_19887448_ChIP-Seq_K562_Human2.02814353
45ER_23166858_ChIP-Seq_MCF-7_Human2.01052221
46STAT3_23295773_ChIP-Seq_U87_Human1.99586152
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97009866
48* P300_19829295_ChIP-Seq_ESCs_Human1.96880322
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95215457
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92452431
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92111227
52* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90434478
53SMAD4_21799915_ChIP-Seq_A2780_Human1.87895620
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.87022416
55FUS_26573619_Chip-Seq_HEK293_Human1.84884556
56DCP1A_22483619_ChIP-Seq_HELA_Human1.84823961
57FOXP3_21729870_ChIP-Seq_TREG_Human1.84021729
58PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78717289
59* PIAS1_25552417_ChIP-Seq_VCAP_Human1.77477041
60TCF4_23295773_ChIP-Seq_U87_Human1.76830003
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76216778
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74966793
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.74708807
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.73953724
65* BCAT_22108803_ChIP-Seq_LS180_Human1.72060280
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.71963516
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.70298787
68KDM5A_27292631_Chip-Seq_BREAST_Human1.69710332
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69423921
70EWS_26573619_Chip-Seq_HEK293_Human1.68460098
71* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67207691
72AR_21572438_ChIP-Seq_LNCaP_Human1.66996117
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65000155
74DROSHA_22980978_ChIP-Seq_HELA_Human1.64758091
75PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61195831
76YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60185347
77CBP_20019798_ChIP-Seq_JUKART_Human1.59812034
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59812034
79TTF2_22483619_ChIP-Seq_HELA_Human1.59550873
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.57092275
81E2F1_21310950_ChIP-Seq_MCF-7_Human1.56153698
82AR_25329375_ChIP-Seq_VCAP_Human1.55648385
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52746937
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52746937
85* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.51290501
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.50587976
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.48813699
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48361607
89* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.46463725
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45865205
91TCF4_22108803_ChIP-Seq_LS180_Human1.43901468
92TP53_16413492_ChIP-PET_HCT116_Human1.42277757
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41811914
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40974997
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.40041777
96EZH2_27294783_Chip-Seq_NPCs_Mouse1.37475024
97* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37305346
98PRDM14_20953172_ChIP-Seq_ESCs_Human1.36283950
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35267470
100MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33908776
101* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33712689
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33338532
103* RUNX2_22187159_ChIP-Seq_PCA_Human1.32315352
104SMAD4_21741376_ChIP-Seq_EPCs_Human1.32125896
105PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30851747
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30409372
107KLF5_20875108_ChIP-Seq_MESCs_Mouse1.29541832
108OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28672747
109NFE2_27457419_Chip-Seq_LIVER_Mouse1.28446566
110ARNT_22903824_ChIP-Seq_MCF-7_Human1.28031600
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27959206
112FLI1_21867929_ChIP-Seq_TH2_Mouse1.27606335
113RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26438484
114CDX2_22108803_ChIP-Seq_LS180_Human1.26379460
115CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26361872
116NANOG_18555785_Chip-Seq_ESCs_Mouse1.25971833
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.25479314
118KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25238894
119ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25018670
120TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24774081
121AHR_22903824_ChIP-Seq_MCF-7_Human1.24114357
122SRF_21415370_ChIP-Seq_HL-1_Mouse1.24023341
123BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23542565
124ELK1_19687146_ChIP-ChIP_HELA_Human1.23141726
125ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23102182
126ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23010991
127CIITA_25753668_ChIP-Seq_RAJI_Human1.22513769
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20862565
129CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20798310
130REST_21632747_ChIP-Seq_MESCs_Mouse1.20621766
131* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19505835
132* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18161783
133NANOG_19829295_ChIP-Seq_ESCs_Human1.17982951
134SOX2_19829295_ChIP-Seq_ESCs_Human1.17982951
135FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17656125
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16761187
137EGR1_19374776_ChIP-ChIP_THP-1_Human1.16527697
138CRX_20693478_ChIP-Seq_RETINA_Mouse1.16493788
139PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.16366796
140KDM2B_26808549_Chip-Seq_REH_Human1.15706161
141NANOG_21062744_ChIP-ChIP_HESCs_Human1.15185084
142FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14367363
143MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14079966
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13990556
145NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13779172
146* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13626693
147SOX2_21211035_ChIP-Seq_LN229_Gbm1.13311148
148* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12880604
149CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12549931
150SMAD_19615063_ChIP-ChIP_OVARY_Human1.11567627
151SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.11381033
152TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11156813
153E2F1_18555785_Chip-Seq_ESCs_Mouse1.10775661
154OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10775122
155* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10333649
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10230316
157* ELK1_22589737_ChIP-Seq_MCF10A_Human1.10213029
158P53_22387025_ChIP-Seq_ESCs_Mouse1.09860810
159SMAD3_21741376_ChIP-Seq_HESCs_Human1.09522036
160RXR_22108803_ChIP-Seq_LS180_Human1.09175318
161TP53_22573176_ChIP-Seq_HFKS_Human1.08044012
162CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07162670
163NOTCH1_21737748_ChIP-Seq_TLL_Human1.06567404
164* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06429367
165TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06075156
166ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04335288
167TP53_18474530_ChIP-ChIP_U2OS_Human1.04147811
168STAT3_18555785_Chip-Seq_ESCs_Mouse1.02640525
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02380018
170BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01897691
171SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01428386
172DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01331882
173EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00995676
174KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00812922
175KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00812922
176KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00812922
177P300_18555785_Chip-Seq_ESCs_Mouse1.00492034
178CMYC_18555785_Chip-Seq_ESCs_Mouse0.99822011
179SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98778112
180SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97340099
181CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96068727
182* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.95611757
183* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93588102
184E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93135184
185* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92885341
186* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92414588
187* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92394308
188HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91084566
189KAP1_27257070_Chip-Seq_ESCs_Mouse0.88250754
190TFEB_21752829_ChIP-Seq_HELA_Human0.88083761
191SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.87551834
192ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86839168
193* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.85754711
194* NANOG_18692474_ChIP-Seq_MEFs_Mouse0.85150495
195* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84450548
196POU5F1_16153702_ChIP-ChIP_HESCs_Human0.83465714
197CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.81883965
198TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81554495
199* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.79876980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.86545760
2MP0003111_abnormal_nucleus_morphology5.16761334
3MP0000569_abnormal_digit_pigmentation4.93767170
4MP0004957_abnormal_blastocyst_morpholog4.43885504
5MP0003718_maternal_effect4.28978627
6MP0008260_abnormal_autophagy4.25346432
7MP0010094_abnormal_chromosome_stability4.20201627
8MP0003077_abnormal_cell_cycle3.73125380
9MP0003195_calcinosis3.53467120
10MP0008057_abnormal_DNA_replication3.46911808
11MP0003123_paternal_imprinting3.14996991
12MP0008058_abnormal_DNA_repair3.12724348
13MP0001501_abnormal_sleep_pattern2.98122505
14MP0003786_premature_aging2.76421406
15MP0003646_muscle_fatigue2.71776939
16MP0009046_muscle_twitch2.69138357
17MP0001968_abnormal_touch/_nociception2.69098679
18MP0005551_abnormal_eye_electrophysiolog2.65283851
19MP0001730_embryonic_growth_arrest2.64903430
20MP0002736_abnormal_nociception_after2.61000910
21MP0009840_abnormal_foam_cell2.51768862
22MP0008932_abnormal_embryonic_tissue2.50525216
23MP0004043_abnormal_pH_regulation2.44809168
24MP0005451_abnormal_body_composition2.27122519
25MP0009745_abnormal_behavioral_response2.15423451
26MP0000427_abnormal_hair_cycle2.12137212
27MP0001661_extended_life_span2.10988810
28MP0003252_abnormal_bile_duct2.10819345
29MP0000350_abnormal_cell_proliferation2.07558644
30MP0001672_abnormal_embryogenesis/_devel2.02541474
31MP0005380_embryogenesis_phenotype2.02541474
32MP0003950_abnormal_plasma_membrane2.00666033
33MP0002138_abnormal_hepatobiliary_system1.92869877
34MP0005670_abnormal_white_adipose1.92388880
35MP0001986_abnormal_taste_sensitivity1.91022246
36MP0005646_abnormal_pituitary_gland1.86717920
37MP0008007_abnormal_cellular_replicative1.84930794
38MP0005377_hearing/vestibular/ear_phenot1.82650297
39MP0003878_abnormal_ear_physiology1.82650297
40MP0001542_abnormal_bone_strength1.81700697
41MP0001486_abnormal_startle_reflex1.79994091
42MP0002837_dystrophic_cardiac_calcinosis1.75573908
43MP0008877_abnormal_DNA_methylation1.75356051
44MP0003984_embryonic_growth_retardation1.74305312
45MP0005253_abnormal_eye_physiology1.74144747
46MP0006276_abnormal_autonomic_nervous1.71779025
47MP0010307_abnormal_tumor_latency1.71578158
48MP0002088_abnormal_embryonic_growth/wei1.70494224
49MP0005174_abnormal_tail_pigmentation1.67946670
50MP0001697_abnormal_embryo_size1.64522232
51MP0004147_increased_porphyrin_level1.63897058
52MP0002080_prenatal_lethality1.62077498
53MP0002396_abnormal_hematopoietic_system1.58407525
54MP0002272_abnormal_nervous_system1.55874879
55MP0001984_abnormal_olfaction1.54669706
56MP0003567_abnormal_fetal_cardiomyocyte1.54652848
57MP0010386_abnormal_urinary_bladder1.52380896
58MP0003045_fibrosis1.51764507
59MP0005310_abnormal_salivary_gland1.49676449
60MP0005395_other_phenotype1.48535469
61MP0003221_abnormal_cardiomyocyte_apopto1.48523575
62MP0002064_seizures1.47819226
63MP0000372_irregular_coat_pigmentation1.43225114
64MP0000750_abnormal_muscle_regeneration1.42328800
65MP0006054_spinal_hemorrhage1.42028515
66MP0009333_abnormal_splenocyte_physiolog1.42021331
67MP0002735_abnormal_chemical_nociception1.39344510
68MP0002876_abnormal_thyroid_physiology1.39296935
69MP0002210_abnormal_sex_determination1.38737423
70MP0003938_abnormal_ear_development1.36404735
71MP0003880_abnormal_central_pattern1.36093305
72MP0000371_diluted_coat_color1.36058811
73MP0002085_abnormal_embryonic_tissue1.35858637
74MP0008872_abnormal_physiological_respon1.35644645
75MP0005085_abnormal_gallbladder_physiolo1.35371353
76MP0002572_abnormal_emotion/affect_behav1.31348585
77MP0002086_abnormal_extraembryonic_tissu1.29586203
78MP0003787_abnormal_imprinting1.28532495
79MP0004145_abnormal_muscle_electrophysio1.28302166
80MP0004084_abnormal_cardiac_muscle1.26675122
81MP0003315_abnormal_perineum_morphology1.25082721
82MP0001145_abnormal_male_reproductive1.24928976
83MP0005171_absent_coat_pigmentation1.24282299
84MP0009672_abnormal_birth_weight1.23222429
85MP0004142_abnormal_muscle_tone1.22238495
86MP0001970_abnormal_pain_threshold1.22048977
87MP0002084_abnormal_developmental_patter1.21480226
88MP0002067_abnormal_sensory_capabilities1.20776229
89MP0005386_behavior/neurological_phenoty1.20149956
90MP0004924_abnormal_behavior1.20149956
91MP0004130_abnormal_muscle_cell1.18701273
92MP0001545_abnormal_hematopoietic_system1.18615794
93MP0005397_hematopoietic_system_phenotyp1.18615794
94MP0003635_abnormal_synaptic_transmissio1.17818131
95MP0001929_abnormal_gametogenesis1.16983561
96MP0002168_other_aberrant_phenotype1.15993880
97MP0005645_abnormal_hypothalamus_physiol1.15248482
98MP0002733_abnormal_thermal_nociception1.10767239
99MP0008875_abnormal_xenobiotic_pharmacok1.10001466
100MP0000653_abnormal_sex_gland1.09769605
101MP0002928_abnormal_bile_duct1.09152202
102MP0002229_neurodegeneration1.08322055
103MP0005410_abnormal_fertilization1.07481132
104MP0000313_abnormal_cell_death1.07209584
105MP0002638_abnormal_pupillary_reflex1.07142736
106MP0005647_abnormal_sex_gland1.06125012
107MP0003633_abnormal_nervous_system1.05902931
108MP0002938_white_spotting1.03732653
109MP0006072_abnormal_retinal_apoptosis1.03721330
110MP0004019_abnormal_vitamin_homeostasis1.03649267
111MP0002557_abnormal_social/conspecific_i1.00867869
112MP0000230_abnormal_systemic_arterial1.00492770
113MP0000747_muscle_weakness1.00399624
114MP0005167_abnormal_blood-brain_barrier1.00176111
115MP0003136_yellow_coat_color0.97887959
116MP0000631_abnormal_neuroendocrine_gland0.97420031
117MP0003806_abnormal_nucleotide_metabolis0.96371770
118MP0000538_abnormal_urinary_bladder0.96208080
119MP0002653_abnormal_ependyma_morphology0.96061209
120MP0010678_abnormal_skin_adnexa0.95856782
121MP0002132_abnormal_respiratory_system0.93646286
122MP0003890_abnormal_embryonic-extraembry0.92596652
123MP0003941_abnormal_skin_development0.92576559
124MP0000358_abnormal_cell_content/0.91629026
125MP0004215_abnormal_myocardial_fiber0.91497508
126MP0002063_abnormal_learning/memory/cond0.90682563
127MP0005266_abnormal_metabolism0.90677566
128MP0009703_decreased_birth_body0.89837114
129MP0001293_anophthalmia0.89394440
130MP0008961_abnormal_basal_metabolism0.88838048
131MP0003183_abnormal_peptide_metabolism0.88743039
132MP0005075_abnormal_melanosome_morpholog0.86473825
133MP0004197_abnormal_fetal_growth/weight/0.85456548
134MP0001963_abnormal_hearing_physiology0.84226078
135MP0005621_abnormal_cell_physiology0.82737599
136MP0004381_abnormal_hair_follicle0.82538893
137MP0001764_abnormal_homeostasis0.82425953
138MP0005332_abnormal_amino_acid0.82326941
139MP0002095_abnormal_skin_pigmentation0.82011357
140MP0003137_abnormal_impulse_conducting0.81529794
141MP0002127_abnormal_cardiovascular_syste0.81118229
142MP0001756_abnormal_urination0.80955824
143MP0003699_abnormal_female_reproductive0.80836978
144MP0000015_abnormal_ear_pigmentation0.79828441
145MP0005384_cellular_phenotype0.79796852
146MP0000627_abnormal_mammary_gland0.79589352
147MP0002019_abnormal_tumor_incidence0.79585789
148MP0002163_abnormal_gland_morphology0.79400217
149MP0002102_abnormal_ear_morphology0.78498777
150MP0002269_muscular_atrophy0.78180896
151MP0005195_abnormal_posterior_eye0.78032395
152MP0006035_abnormal_mitochondrial_morpho0.77364530
153MP0000428_abnormal_craniofacial_morphol0.77179377
154MP0001664_abnormal_digestion0.77024249
155MP0004085_abnormal_heartbeat0.76688265
156MP0003119_abnormal_digestive_system0.76272524
157MP0005389_reproductive_system_phenotype0.74585787
158MP0004885_abnormal_endolymph0.74514827
159MP0003631_nervous_system_phenotype0.74394900
160MP0002161_abnormal_fertility/fecundity0.73318124
161MP0002734_abnormal_mechanical_nocicepti0.72635861
162MP0002092_abnormal_eye_morphology0.71858197
163MP0002752_abnormal_somatic_nervous0.71449882
164MP0003937_abnormal_limbs/digits/tail_de0.71033735
165MP0006292_abnormal_olfactory_placode0.68039773
166MP0001119_abnormal_female_reproductive0.67154667
167MP0002160_abnormal_reproductive_system0.66460795
168MP0003698_abnormal_male_reproductive0.65844187
169MP0000647_abnormal_sebaceous_gland0.64925912
170MP0006138_congestive_heart_failure0.64159004
171MP0006036_abnormal_mitochondrial_physio0.63914289
172MP0000490_abnormal_crypts_of0.61744586
173MP0003936_abnormal_reproductive_system0.61540774
174MP0000383_abnormal_hair_follicle0.61212279
175MP0003879_abnormal_hair_cell0.60712408
176MP0008995_early_reproductive_senescence0.58253937
177MP0001727_abnormal_embryo_implantation0.56182190
178MP0003656_abnormal_erythrocyte_physiolo0.53259209
179MP0003121_genomic_imprinting0.52798328
180MP0005058_abnormal_lysosome_morphology0.52268252
181MP0004264_abnormal_extraembryonic_tissu0.51874805
182MP0004808_abnormal_hematopoietic_stem0.51055052
183MP0005330_cardiomyopathy0.50382179
184MP0001485_abnormal_pinna_reflex0.50115674

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinemia (HP:0002154)6.28650685
2Genetic anticipation (HP:0003743)6.27750429
3Birth length less than 3rd percentile (HP:0003561)5.93393176
4Impulsivity (HP:0100710)5.55366727
5Breast hypoplasia (HP:0003187)5.41741149
6Hyperglycinuria (HP:0003108)5.05399364
7Progressive cerebellar ataxia (HP:0002073)5.01187884
8Gaze-evoked nystagmus (HP:0000640)4.85898257
9Cerebral hypomyelination (HP:0006808)4.79462213
10Pancreatic cysts (HP:0001737)4.74617786
11Ureteral duplication (HP:0000073)4.45104171
12Hyperventilation (HP:0002883)4.28411706
13Pancreatic fibrosis (HP:0100732)4.25059694
14Abnormality of serine family amino acid metabolism (HP:0010894)4.24809755
15Abnormality of glycine metabolism (HP:0010895)4.24809755
16Rough bone trabeculation (HP:0100670)4.23915760
17Carpal bone hypoplasia (HP:0001498)4.20022452
18Abnormality of the umbilical cord (HP:0010881)4.17962931
19True hermaphroditism (HP:0010459)4.06098739
20Entropion (HP:0000621)3.77038326
21Patellar aplasia (HP:0006443)3.61668772
22Dysmetric saccades (HP:0000641)3.58198856
23Aplasia/Hypoplasia of the patella (HP:0006498)3.55037797
24Abnormality of serum amino acid levels (HP:0003112)3.47256634
25Abnormality of the labia minora (HP:0012880)3.45395641
26Molar tooth sign on MRI (HP:0002419)3.45271582
27Abnormality of midbrain morphology (HP:0002418)3.45271582
28Attenuation of retinal blood vessels (HP:0007843)3.44717000
29Congenital stationary night blindness (HP:0007642)3.40760701
30Abnormal ciliary motility (HP:0012262)3.38641083
31Chronic hepatic failure (HP:0100626)3.37025107
32Absent/shortened dynein arms (HP:0200106)3.31689980
33Dynein arm defect of respiratory motile cilia (HP:0012255)3.31689980
34Abnormality of the renal cortex (HP:0011035)3.30757741
35Cystic liver disease (HP:0006706)3.30346024
36Gout (HP:0001997)3.27108568
37Central scotoma (HP:0000603)3.22639445
38Nephronophthisis (HP:0000090)3.21547578
39Abnormal trabecular bone morphology (HP:0100671)3.18428770
40Abnormality of the anterior horn cell (HP:0006802)3.17002208
41Degeneration of anterior horn cells (HP:0002398)3.17002208
42Multiple enchondromatosis (HP:0005701)3.14204836
43Clumsiness (HP:0002312)3.13332361
44Abnormality of the renal medulla (HP:0100957)3.08361790
45Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.05889527
46Atrioventricular block (HP:0001678)3.05229515
47Focal seizures (HP:0007359)3.05169286
48CNS hypomyelination (HP:0003429)3.04579647
49Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.03475472
50Premature ovarian failure (HP:0008209)3.02294697
51Abnormal respiratory motile cilium physiology (HP:0012261)3.01095888
52Aplasia/Hypoplasia of the tibia (HP:0005772)2.97670351
53Congenital sensorineural hearing impairment (HP:0008527)2.93281083
54Secondary amenorrhea (HP:0000869)2.91183939
55Bundle branch block (HP:0011710)2.90934868
56Dialeptic seizures (HP:0011146)2.90684187
57Protruding tongue (HP:0010808)2.86876841
58Bony spicule pigmentary retinopathy (HP:0007737)2.85952115
59Febrile seizures (HP:0002373)2.84862959
60Absent radius (HP:0003974)2.83040508
61Muscle fiber splitting (HP:0003555)2.82070231
62Ventricular fibrillation (HP:0001663)2.78993547
63Patent foramen ovale (HP:0001655)2.78894074
64Absence seizures (HP:0002121)2.78007230
65Absent speech (HP:0001344)2.77555392
66Death in infancy (HP:0001522)2.77230503
67Tetraplegia (HP:0002445)2.77041405
68Abnormality of macular pigmentation (HP:0008002)2.74602687
69Abnormality of the distal phalanges of the toes (HP:0010182)2.72295843
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.70412546
71Medial flaring of the eyebrow (HP:0010747)2.70105442
72Progressive muscle weakness (HP:0003323)2.69193710
73Abolished electroretinogram (ERG) (HP:0000550)2.68184116
74Keratoconus (HP:0000563)2.68180727
75Increased corneal curvature (HP:0100692)2.68180727
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.66521806
77Fair hair (HP:0002286)2.66331037
78Oligodactyly (hands) (HP:0001180)2.66302979
79Absent forearm bone (HP:0003953)2.65214227
80Aplasia involving forearm bones (HP:0009822)2.65214227
81Premature rupture of membranes (HP:0001788)2.63936960
82Abnormal respiratory epithelium morphology (HP:0012253)2.62800877
83Abnormal respiratory motile cilium morphology (HP:0005938)2.62800877
84Urinary bladder sphincter dysfunction (HP:0002839)2.60675861
85Abnormalities of placenta or umbilical cord (HP:0001194)2.55057070
86Restlessness (HP:0000711)2.55034164
87Delusions (HP:0000746)2.49924136
88Megaloblastic anemia (HP:0001889)2.49656395
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49293446
90Abnormality of alanine metabolism (HP:0010916)2.49293446
91Hyperalaninemia (HP:0003348)2.49293446
92Areflexia of lower limbs (HP:0002522)2.48393755
93Hypoplasia of the capital femoral epiphysis (HP:0003090)2.48365995
94Tubular atrophy (HP:0000092)2.46473427
95Aplasia/Hypoplasia of the tongue (HP:0010295)2.46393485
96Short nail (HP:0001799)2.45847894
97Microretrognathia (HP:0000308)2.45357827
98Hyperglycemia (HP:0003074)2.44869597
99Congenital hepatic fibrosis (HP:0002612)2.42711915
100Oral leukoplakia (HP:0002745)2.42201691
101Focal motor seizures (HP:0011153)2.42096684
102Decreased circulating renin level (HP:0003351)2.41861906
103Abnormal umbilical cord blood vessels (HP:0011403)2.41006897
104Single umbilical artery (HP:0001195)2.41006897
105Abnormality of the fetal cardiovascular system (HP:0010948)2.41006897
106Sparse eyelashes (HP:0000653)2.39300663
107Personality changes (HP:0000751)2.37861839
108Congenital, generalized hypertrichosis (HP:0004540)2.37264425
109Severe visual impairment (HP:0001141)2.34424571
110Abnormality of the preputium (HP:0100587)2.34201090
111Dysautonomia (HP:0002459)2.33915030
112Prostate neoplasm (HP:0100787)2.32825127
113Scotoma (HP:0000575)2.32654973
114Oligodactyly (HP:0012165)2.29998721
115Rhinitis (HP:0012384)2.29159889
116Sparse lateral eyebrow (HP:0005338)2.27915453
117Spinal muscular atrophy (HP:0007269)2.27706698
118Pustule (HP:0200039)2.27625566
119Action tremor (HP:0002345)2.27292210
120Facial diplegia (HP:0001349)2.27175597
121Sclerocornea (HP:0000647)2.26939164
122Decreased central vision (HP:0007663)2.26863185
123Pendular nystagmus (HP:0012043)2.26781960
124Furrowed tongue (HP:0000221)2.26554001
125Aplasia/Hypoplasia involving the musculature (HP:0001460)2.25873758
126Stillbirth (HP:0003826)2.25026400
127Meckel diverticulum (HP:0002245)2.24388130
128Brittle hair (HP:0002299)2.24216223
129Inability to walk (HP:0002540)2.24178073
130Submucous cleft hard palate (HP:0000176)2.24048858
131Irregular epiphyses (HP:0010582)2.22576527
132Pelvic girdle muscle weakness (HP:0003749)2.21742109
133Trismus (HP:0000211)2.21459827
134Broad-based gait (HP:0002136)2.18928509
135Gait imbalance (HP:0002141)2.18781931
136Type II lissencephaly (HP:0007260)2.18410056
137Osteolytic defects of the phalanges of the hand (HP:0009771)2.17888747
138Osteolytic defects of the hand bones (HP:0009699)2.17888747
139Facial hemangioma (HP:0000329)2.16196416
140Congenital primary aphakia (HP:0007707)2.16019568
141Atrophy/Degeneration involving motor neurons (HP:0007373)2.14883503
142Prolonged neonatal jaundice (HP:0006579)2.14037508
143Abnormality of the hepatic vasculature (HP:0006707)2.13748736
144Glucose intolerance (HP:0000833)2.13691255
145Renal cortical cysts (HP:0000803)2.13603492
146Abnormal spermatogenesis (HP:0008669)2.13099416
147Abnormal drinking behavior (HP:0030082)2.12305489
148Polydipsia (HP:0001959)2.12305489
149Retinitis pigmentosa (HP:0000510)2.11695791
150Reduced subcutaneous adipose tissue (HP:0003758)2.11602848
151Postural instability (HP:0002172)2.11535265
152Selective tooth agenesis (HP:0001592)2.11376682
153Generalized hypopigmentation of hair (HP:0011358)2.09766112
154Glossoptosis (HP:0000162)2.07636279
155Cerebellar dysplasia (HP:0007033)2.07321975
156Chromosomal breakage induced by crosslinking agents (HP:0003221)2.07089948
157Shoulder girdle muscle weakness (HP:0003547)2.07031416
158Postaxial foot polydactyly (HP:0001830)2.06944126
159Hypoplastic ischia (HP:0003175)2.06866349
160Breast aplasia (HP:0100783)2.06686511
161Anencephaly (HP:0002323)2.06464867
162Difficulty climbing stairs (HP:0003551)2.05305468
163Abnormality of the ileum (HP:0001549)2.04913521
164Abnormal rod and cone electroretinograms (HP:0008323)2.04695230
165Horseshoe kidney (HP:0000085)2.04313155
166Progressive inability to walk (HP:0002505)2.03681825
167Widely spaced teeth (HP:0000687)2.01880072
168Impaired smooth pursuit (HP:0007772)2.01492559
169Prominent nose (HP:0000448)2.01337539
170Ileus (HP:0002595)1.99528964
171Double outlet right ventricle (HP:0001719)1.98388779
172Congenital malformation of the right heart (HP:0011723)1.98388779
173Bile duct proliferation (HP:0001408)1.97901133
174Abnormal biliary tract physiology (HP:0012439)1.97901133
175Genital tract atresia (HP:0001827)1.97793319
176Abnormality of the ischium (HP:0003174)1.96735399
177Postnatal microcephaly (HP:0005484)1.96274329
178Preaxial foot polydactyly (HP:0001841)1.94227035
179Spastic paraparesis (HP:0002313)1.94191991
180Aplasia/Hypoplasia of the breasts (HP:0010311)1.93808791
181Male pseudohermaphroditism (HP:0000037)1.92642561
182Bone marrow hypocellularity (HP:0005528)1.92358130
183Abnormality of chromosome stability (HP:0003220)1.92195203
184Increased cerebral lipofuscin (HP:0011813)1.92175916
185Tubulointerstitial nephritis (HP:0001970)1.91457538
186Absent epiphyses (HP:0010577)1.90091481
187Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90091481
188Ankle contracture (HP:0006466)1.90033516
189Constricted visual fields (HP:0001133)1.89574932
190Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89214239
191Nephrogenic diabetes insipidus (HP:0009806)1.87641289
192Small hand (HP:0200055)1.86555865
193Vaginal atresia (HP:0000148)1.85536837
194Preaxial hand polydactyly (HP:0001177)1.85252650
195Short foot (HP:0001773)1.85089477
196Highly arched eyebrow (HP:0002553)1.83327446
197Chorioretinal atrophy (HP:0000533)1.82166207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.02616944
2WEE15.41299932
3TSSK63.57275580
4AKT33.23721954
5EIF2AK13.05443943
6NEK22.97376825
7BMPR1B2.82869182
8BRSK22.75263086
9PNCK2.71213498
10NME22.58952089
11MKNK22.48817418
12ADRBK22.45419214
13OXSR12.32416338
14NEK12.27921390
15STK162.27809797
16PLK32.24516524
17PLK42.19022872
18PLK12.16894868
19CDK192.12743699
20SRPK12.09700702
21TTK2.01109722
22FRK11.0082682
23PDK31.99066694
24PDK41.99066694
25EIF2AK31.99051432
26ACVR1B1.87697750
27BRSK11.85014604
28NTRK31.81805068
29DYRK31.81245887
30GRK11.80810450
31CCNB11.80450989
32MKNK11.75142889
33EPHA21.73990322
34PDK21.67751922
35CASK1.65838031
36TAOK31.61668560
37MAP4K21.59331301
38PIK3CG1.54457984
39INSRR1.53818227
40ALK1.46736241
41MAPK131.43453794
42ARAF1.36803781
43CDC71.35828090
44AURKB1.34225347
45CHEK21.32042541
46TNK21.27736032
47LATS21.27468366
48STK31.23496766
49ADRBK11.20623347
50AURKA1.18123403
51BRAF1.17889839
52MAP3K71.16650142
53STK391.12084700
54MAP3K41.08551866
55FER1.08121455
56CDK71.04673531
57ZAK1.03451744
58TXK1.03273510
59PTK2B1.01920257
60CDK41.01584846
61CHEK10.93961661
62TGFBR10.92370183
63STK38L0.91615376
64TEC0.91163575
65PINK10.90965997
66EIF2AK20.87879557
67VRK10.85324596
68MAP3K80.83763523
69PRKCI0.83640262
70TESK20.82854616
71RPS6KA40.82455675
72DAPK20.81576898
73PRKCE0.81102054
74PAK30.79934056
75TNIK0.78817143
76PIM20.78799050
77PRKAA20.76391238
78ATR0.75764607
79CSNK1G30.75278580
80PIK3CA0.72984000
81CDK20.70612574
82EPHA40.70023710
83TRPM70.68469334
84CSNK1G10.65609185
85PAK10.64582108
86NUAK10.64355413
87WNK40.64216797
88CSNK1E0.62945137
89IRAK10.59380502
90PLK20.58995510
91SGK20.58143633
92CSNK2A20.57984636
93NLK0.57630320
94CSNK1A1L0.54822461
95CAMK2A0.54546665
96MELK0.54304826
97BCR0.54060453
98CSNK2A10.53556229
99WNK30.52135710
100CDK10.51939972
101MARK10.51674923
102PRKAA10.50295756
103STK110.50067796
104OBSCN0.49683874
105PIM10.49581949
106STK240.48866414
107MUSK0.48248726
108ERBB20.46659459
109CSNK1G20.45951647
110CDK30.45559529
111STK40.43860813
112PKN10.43298874
113KIT0.42481345
114NME10.41819415
115CAMK10.41237547
116FGFR20.39969362
117MAP3K90.39716011
118ATM0.39563846
119BRD40.39008468
120CAMKK20.38967463
121CDK60.38433649
122BCKDK0.37285433
123MAP2K20.36589475
124PRKCG0.36426434
125CSNK1D0.35687606
126ITK0.34660183
127MTOR0.34628998
128SIK20.34528591
129PRKACA0.33828597
130LATS10.33744647
131RAF10.32933552
132STK380.32910023
133MAPKAPK50.32251913
134CAMK1G0.32229589
135PRKG10.31874105
136CAMK40.31532565
137TIE10.31192883
138MARK30.30943229
139CHUK0.30890814
140SGK10.30854605
141DYRK20.30562645
142PRKACB0.29040145
143CSNK1A10.28963281
144MAP2K10.28707178
145IKBKB0.28070305
146MAPK150.26065871
147PDK10.25921560
148PRKCA0.25597761
149PRKCB0.24540296
150DYRK1A0.24436161
151AKT20.24113215
152NEK60.23247500
153STK100.22684222
154ABL10.22418814
155MAPK70.22376745
156MAPKAPK30.22141009
157IRAK30.20990046
158RPS6KA50.18511360
159MAPK100.17344683
160TLK10.17174678
161MAP3K30.16855590
162MAP3K50.16290514
163RPS6KB20.16190363
164GSK3B0.14167168
165TAOK20.13773316
166PASK0.13122510
167PRKDC0.10960808
168MAPK90.10259332
169GRK50.10081952
170CDK120.07822606

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007507.04149525
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.68576362
3RNA polymerase_Homo sapiens_hsa030204.66821503
4RNA transport_Homo sapiens_hsa030133.56615921
5Proteasome_Homo sapiens_hsa030503.49389438
6Primary bile acid biosynthesis_Homo sapiens_hsa001203.20755194
7DNA replication_Homo sapiens_hsa030302.63998807
8Regulation of autophagy_Homo sapiens_hsa041402.60246943
9ABC transporters_Homo sapiens_hsa020102.59455200
10Spliceosome_Homo sapiens_hsa030402.56194376
11Tryptophan metabolism_Homo sapiens_hsa003802.56016250
12Nicotine addiction_Homo sapiens_hsa050332.47424291
13Pyrimidine metabolism_Homo sapiens_hsa002402.45892138
14Cell cycle_Homo sapiens_hsa041102.44346103
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.38902662
16Phototransduction_Homo sapiens_hsa047442.37159856
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.26564232
18Mismatch repair_Homo sapiens_hsa034302.24333527
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22571429
20Basal transcription factors_Homo sapiens_hsa030222.18823571
21Steroid hormone biosynthesis_Homo sapiens_hsa001402.14222108
22Folate biosynthesis_Homo sapiens_hsa007902.06055394
23Nucleotide excision repair_Homo sapiens_hsa034202.04901297
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.01421686
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.92634181
26Base excision repair_Homo sapiens_hsa034101.90769234
27Olfactory transduction_Homo sapiens_hsa047401.89304560
28Nitrogen metabolism_Homo sapiens_hsa009101.88894909
29Homologous recombination_Homo sapiens_hsa034401.87617933
30Taste transduction_Homo sapiens_hsa047421.82569460
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.82504100
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75422972
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.72592293
34Ribosome_Homo sapiens_hsa030101.69169433
35Morphine addiction_Homo sapiens_hsa050321.68720521
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66483425
37Purine metabolism_Homo sapiens_hsa002301.64750502
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.59438197
39Vitamin digestion and absorption_Homo sapiens_hsa049771.57961455
40p53 signaling pathway_Homo sapiens_hsa041151.54876660
41Caffeine metabolism_Homo sapiens_hsa002321.52740507
42Chemical carcinogenesis_Homo sapiens_hsa052041.51343565
43Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49231039
44Histidine metabolism_Homo sapiens_hsa003401.49180520
45Pentose phosphate pathway_Homo sapiens_hsa000301.46957084
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.45270330
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44915006
48Salivary secretion_Homo sapiens_hsa049701.44180990
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.42785671
50Fanconi anemia pathway_Homo sapiens_hsa034601.42214731
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.42125270
52Propanoate metabolism_Homo sapiens_hsa006401.42048840
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41287963
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39748142
55Glutamatergic synapse_Homo sapiens_hsa047241.37077278
56Oocyte meiosis_Homo sapiens_hsa041141.35987453
57Circadian entrainment_Homo sapiens_hsa047131.34325738
58Calcium signaling pathway_Homo sapiens_hsa040201.30916940
59mRNA surveillance pathway_Homo sapiens_hsa030151.29447639
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.29202702
61Serotonergic synapse_Homo sapiens_hsa047261.28528590
62GABAergic synapse_Homo sapiens_hsa047271.24381389
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23719686
64Dorso-ventral axis formation_Homo sapiens_hsa043201.21704400
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.19039792
66Fatty acid biosynthesis_Homo sapiens_hsa000611.17873097
67Biosynthesis of amino acids_Homo sapiens_hsa012301.16468410
68Epstein-Barr virus infection_Homo sapiens_hsa051691.15721059
69Ovarian steroidogenesis_Homo sapiens_hsa049131.14266730
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13673440
71One carbon pool by folate_Homo sapiens_hsa006701.12032063
72RNA degradation_Homo sapiens_hsa030181.09100469
73Lysine degradation_Homo sapiens_hsa003101.08795272
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07804414
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02628931
76Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99291319
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.98997288
78Insulin secretion_Homo sapiens_hsa049110.98897947
79Fatty acid degradation_Homo sapiens_hsa000710.96913595
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.94009657
81Fructose and mannose metabolism_Homo sapiens_hsa000510.93032668
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90534250
83Sulfur relay system_Homo sapiens_hsa041220.85016459
84Gastric acid secretion_Homo sapiens_hsa049710.84621542
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82787176
862-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80739994
87Long-term depression_Homo sapiens_hsa047300.79790747
88cAMP signaling pathway_Homo sapiens_hsa040240.75093642
89Selenocompound metabolism_Homo sapiens_hsa004500.72916171
90Cholinergic synapse_Homo sapiens_hsa047250.72830914
91Oxytocin signaling pathway_Homo sapiens_hsa049210.71972592
92Circadian rhythm_Homo sapiens_hsa047100.70559407
93Peroxisome_Homo sapiens_hsa041460.68597942
94Non-homologous end-joining_Homo sapiens_hsa034500.67274131
95Carbon metabolism_Homo sapiens_hsa012000.66189502
96Renin secretion_Homo sapiens_hsa049240.64939397
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60185201
98Dopaminergic synapse_Homo sapiens_hsa047280.55048946
99Fatty acid metabolism_Homo sapiens_hsa012120.54946801
100Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54891507
101Antigen processing and presentation_Homo sapiens_hsa046120.52864696
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.52438877
103Arginine and proline metabolism_Homo sapiens_hsa003300.52159010
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50547576
105mTOR signaling pathway_Homo sapiens_hsa041500.49678428
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.49451548
107Pancreatic secretion_Homo sapiens_hsa049720.48627812
108Glutathione metabolism_Homo sapiens_hsa004800.48141289
109Bile secretion_Homo sapiens_hsa049760.47446835
110Metabolic pathways_Homo sapiens_hsa011000.45308179
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44713228
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42673735
113PPAR signaling pathway_Homo sapiens_hsa033200.41498502
114Type II diabetes mellitus_Homo sapiens_hsa049300.40085398
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39813198
116Platelet activation_Homo sapiens_hsa046110.39177676
117Graft-versus-host disease_Homo sapiens_hsa053320.34987701
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34908921
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.31771117
120Ras signaling pathway_Homo sapiens_hsa040140.30446686
121Viral carcinogenesis_Homo sapiens_hsa052030.29218052
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28660012
123Glycerolipid metabolism_Homo sapiens_hsa005610.28600055
124Complement and coagulation cascades_Homo sapiens_hsa046100.28462276
125Cocaine addiction_Homo sapiens_hsa050300.27864024
126FoxO signaling pathway_Homo sapiens_hsa040680.27447513
127Linoleic acid metabolism_Homo sapiens_hsa005910.26837622
128Herpes simplex infection_Homo sapiens_hsa051680.26450036
129Melanoma_Homo sapiens_hsa052180.25004816
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.24062884
131N-Glycan biosynthesis_Homo sapiens_hsa005100.23462869
132Lysosome_Homo sapiens_hsa041420.23441025
133beta-Alanine metabolism_Homo sapiens_hsa004100.23076173
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22911339
135Renin-angiotensin system_Homo sapiens_hsa046140.22900084
136Sphingolipid metabolism_Homo sapiens_hsa006000.22811137
137Arachidonic acid metabolism_Homo sapiens_hsa005900.22072757
138Butanoate metabolism_Homo sapiens_hsa006500.21025975
139Hippo signaling pathway_Homo sapiens_hsa043900.18708066
140Inositol phosphate metabolism_Homo sapiens_hsa005620.16717086
141Mineral absorption_Homo sapiens_hsa049780.16057984
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14097278
143Galactose metabolism_Homo sapiens_hsa000520.13915025
144HTLV-I infection_Homo sapiens_hsa051660.11401449
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.11000803
146Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10385670
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.08528263
148HIF-1 signaling pathway_Homo sapiens_hsa040660.08470632
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08166523
150Hedgehog signaling pathway_Homo sapiens_hsa043400.06150237
151Small cell lung cancer_Homo sapiens_hsa052220.06092445
152MicroRNAs in cancer_Homo sapiens_hsa052060.05490366
153Retinol metabolism_Homo sapiens_hsa008300.04883061
154Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04542313
155Tight junction_Homo sapiens_hsa045300.03246380
156AMPK signaling pathway_Homo sapiens_hsa041520.02912613
157Renal cell carcinoma_Homo sapiens_hsa052110.02013842
158Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.01417125
159NOD-like receptor signaling pathway_Homo sapiens_hsa046210.01295220
160Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.01114245
161Fat digestion and absorption_Homo sapiens_hsa04975-0.0363118
162Huntingtons disease_Homo sapiens_hsa05016-0.0351120
163Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0295740
164Ether lipid metabolism_Homo sapiens_hsa00565-0.0276480
165Prion diseases_Homo sapiens_hsa05020-0.0242491
166Legionellosis_Homo sapiens_hsa05134-0.0199340
167Arginine biosynthesis_Homo sapiens_hsa00220-0.0126680
168Thyroid cancer_Homo sapiens_hsa05216-0.0110106
169Steroid biosynthesis_Homo sapiens_hsa00100-0.0050181
170Thyroid hormone signaling pathway_Homo sapiens_hsa04919-0.0010625

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