FBXO16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.36691172
2intraciliary transport (GO:0042073)4.14667968
3protein localization to cilium (GO:0061512)3.99976895
4Golgi transport vesicle coating (GO:0048200)3.90160828
5COPI coating of Golgi vesicle (GO:0048205)3.90160828
6protein deneddylation (GO:0000338)3.74836543
7cullin deneddylation (GO:0010388)3.74134899
8behavioral response to nicotine (GO:0035095)3.73827311
9nucleobase catabolic process (GO:0046113)3.58412797
10neuron cell-cell adhesion (GO:0007158)3.52855551
11protein complex biogenesis (GO:0070271)3.51521520
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.48686263
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42229783
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.42229783
15NADH dehydrogenase complex assembly (GO:0010257)3.42229783
16chaperone-mediated protein transport (GO:0072321)3.38196586
17postsynaptic membrane organization (GO:0001941)3.36568278
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.27451699
19cilium movement (GO:0003341)3.20405002
20mitochondrial respiratory chain complex assembly (GO:0033108)3.19437433
21protein maturation by protein folding (GO:0022417)3.19214316
22axonemal dynein complex assembly (GO:0070286)3.19002148
23vocalization behavior (GO:0071625)3.18028643
24tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.16428722
25RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.16428722
26presynaptic membrane assembly (GO:0097105)3.15843083
27respiratory chain complex IV assembly (GO:0008535)3.14231660
28regulation of synaptic vesicle exocytosis (GO:2000300)3.14140273
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13491116
30platelet dense granule organization (GO:0060155)3.13134314
31exocrine pancreas development (GO:0031017)3.12022285
32sequestering of actin monomers (GO:0042989)3.04742066
33positive regulation of mitochondrial fission (GO:0090141)3.01869137
34synaptic vesicle exocytosis (GO:0016079)3.01789463
35ER overload response (GO:0006983)3.01440774
36protein polyglutamylation (GO:0018095)3.01085763
37regulation of cilium movement (GO:0003352)3.00623831
38retinal ganglion cell axon guidance (GO:0031290)2.95004162
39detection of calcium ion (GO:0005513)2.92507397
40olfactory bulb development (GO:0021772)2.90384706
41axoneme assembly (GO:0035082)2.89857678
42establishment of protein localization to mitochondrial membrane (GO:0090151)2.87514303
43positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.83593584
44response to pheromone (GO:0019236)2.80839964
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.80100882
46DNA double-strand break processing (GO:0000729)2.79501552
47sensory perception of smell (GO:0007608)2.78934107
48regulation of synaptic vesicle transport (GO:1902803)2.78468677
49positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77904624
50presynaptic membrane organization (GO:0097090)2.77239937
51cerebellum development (GO:0021549)2.77235878
52negative regulation of transcription regulatory region DNA binding (GO:2000678)2.77220040
53female mating behavior (GO:0060180)2.75276712
54nonmotile primary cilium assembly (GO:0035058)2.75134978
55regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74797728
56regulation of short-term neuronal synaptic plasticity (GO:0048172)2.73786032
57respiratory electron transport chain (GO:0022904)2.72212608
58electron transport chain (GO:0022900)2.71106517
59epithelial cilium movement (GO:0003351)2.67937738
60inositol phosphate catabolic process (GO:0071545)2.67623549
61signal peptide processing (GO:0006465)2.67495005
62negative regulation of telomere maintenance (GO:0032205)2.66284944
63mannosylation (GO:0097502)2.65577908
64guanosine-containing compound biosynthetic process (GO:1901070)2.65299906
65glutamate secretion (GO:0014047)2.65047478
66cytochrome complex assembly (GO:0017004)2.64639953
67neuronal action potential propagation (GO:0019227)2.63353011
68maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57665918
69protein-cofactor linkage (GO:0018065)2.57282704
70calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.57027916
71limb bud formation (GO:0060174)2.56332436
72cilium assembly (GO:0042384)2.55428049
73somite development (GO:0061053)2.55030263
74DNA damage response, detection of DNA damage (GO:0042769)2.53327965
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.51866272
76cilium organization (GO:0044782)2.50700276
77energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.50169233
78ATP hydrolysis coupled proton transport (GO:0015991)2.50169233
79RNA capping (GO:0036260)2.49313463
807-methylguanosine RNA capping (GO:0009452)2.49313463
81retinal cone cell development (GO:0046549)2.48612996
82cilium or flagellum-dependent cell motility (GO:0001539)2.48065654
837-methylguanosine mRNA capping (GO:0006370)2.47708815
84regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.47448245
85regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.46929433
86photoreceptor cell maintenance (GO:0045494)2.46646958
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45772801
88regulation of mitotic spindle checkpoint (GO:1903504)2.45772801
89synapse assembly (GO:0007416)2.45314410
90peptidyl-arginine N-methylation (GO:0035246)2.44592974
91peptidyl-arginine methylation (GO:0018216)2.44592974
92glandular epithelial cell differentiation (GO:0002067)2.44557470
93regulation of glutamate receptor signaling pathway (GO:1900449)2.44477450
94water-soluble vitamin biosynthetic process (GO:0042364)2.43839511
95regulation of microtubule-based movement (GO:0060632)2.43203160
96positive regulation of membrane potential (GO:0045838)2.42907879
97cilium morphogenesis (GO:0060271)2.42904512
98cellular ketone body metabolic process (GO:0046950)2.42877401
99detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42282607
100melanosome transport (GO:0032402)2.42260689
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39936498
102synaptic transmission, glutamatergic (GO:0035249)2.39904894
103protein neddylation (GO:0045116)2.38961030
104smoothened signaling pathway (GO:0007224)2.38895484
105protein retention in ER lumen (GO:0006621)2.38809610
106digestion (GO:0007586)2.38589879
107mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.38162435
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.38001177
109establishment of melanosome localization (GO:0032401)2.37937962
110ribonucleoprotein complex disassembly (GO:0032988)2.37572968
111regulation of female receptivity (GO:0045924)2.36965038
112cell migration in hindbrain (GO:0021535)2.36872414
113synaptic vesicle endocytosis (GO:0048488)2.35435030
114neuron-neuron synaptic transmission (GO:0007270)2.35077045
115replication fork processing (GO:0031297)2.34941157
116cellular component assembly involved in morphogenesis (GO:0010927)2.34898262
117axonal fasciculation (GO:0007413)2.34430352
118insulin secretion (GO:0030073)2.34227474
119neurotransmitter-gated ion channel clustering (GO:0072578)2.33828719
120peptidyl-arginine omega-N-methylation (GO:0035247)2.33463905
121anterograde synaptic vesicle transport (GO:0048490)2.33032430
122calcium-mediated signaling using intracellular calcium source (GO:0035584)2.32408486
123protein insertion into membrane (GO:0051205)2.32296405
124protein localization to synapse (GO:0035418)2.31493525
125centriole replication (GO:0007099)2.31202729
126peptidyl-histidine modification (GO:0018202)2.29772848
127neural tube formation (GO:0001841)2.28880936
128membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.28142245
129innervation (GO:0060384)2.27413372
130phosphorylated carbohydrate dephosphorylation (GO:0046838)2.27317980
131inositol phosphate dephosphorylation (GO:0046855)2.27317980
132pigment granule transport (GO:0051904)2.27073586
133aldehyde catabolic process (GO:0046185)2.26784993
134paraxial mesoderm development (GO:0048339)2.26702751
135calcium ion-dependent exocytosis (GO:0017156)2.26383075
136behavioral response to ethanol (GO:0048149)2.25490502
137nucleobase biosynthetic process (GO:0046112)2.25357837
138substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.25055739
139substrate-independent telencephalic tangential migration (GO:0021826)2.25055739
140transmission of nerve impulse (GO:0019226)2.25037714
141mechanosensory behavior (GO:0007638)2.24888775
142melanosome localization (GO:0032400)2.24254254
143hindbrain development (GO:0030902)2.24045158
144establishment of pigment granule localization (GO:0051905)2.23637670
145regulation of feeding behavior (GO:0060259)2.23461245
146cholesterol biosynthetic process (GO:0006695)2.23074291
147gamma-aminobutyric acid transport (GO:0015812)2.22995504
148forebrain neuron differentiation (GO:0021879)2.22818556
149GTP biosynthetic process (GO:0006183)2.22691369
150regulation of glucocorticoid secretion (GO:2000849)2.22462553
151regulation of telomere maintenance (GO:0032204)2.21606238
152negative regulation of dendrite morphogenesis (GO:0050774)2.20707343
153transferrin transport (GO:0033572)2.20643593
154hippocampus development (GO:0021766)2.20549295
155organelle disassembly (GO:1903008)2.20436427
156photoreceptor cell development (GO:0042461)2.20248383
157GPI anchor metabolic process (GO:0006505)2.20012889
158negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.19903498
159negative regulation of microtubule polymerization (GO:0031115)2.19812965
160branched-chain amino acid catabolic process (GO:0009083)2.19054430
161preassembly of GPI anchor in ER membrane (GO:0016254)2.19024002
162somatic hypermutation of immunoglobulin genes (GO:0016446)2.18667084
163regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.17921713
164energy coupled proton transport, down electrochemical gradient (GO:0015985)2.17795963
165ATP synthesis coupled proton transport (GO:0015986)2.17795963
166positive regulation of synapse maturation (GO:0090129)2.16503814
167histone arginine methylation (GO:0034969)2.16361973

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.94886942
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10937254
3GBX2_23144817_ChIP-Seq_PC3_Human2.76104084
4RBPJ_22232070_ChIP-Seq_NCS_Mouse2.70767534
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61508339
6PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.58032027
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.56826485
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.56574878
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34244809
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.21883882
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.20854352
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.10882205
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.07330036
14EWS_26573619_Chip-Seq_HEK293_Human2.01374805
15SALL1_21062744_ChIP-ChIP_HESCs_Human1.96911819
16ETS1_20019798_ChIP-Seq_JURKAT_Human1.93065501
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.87263489
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84621649
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84540724
20REST_21632747_ChIP-Seq_MESCs_Mouse1.82528664
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81776715
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80072539
23TAF15_26573619_Chip-Seq_HEK293_Human1.79489864
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76464554
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65548522
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62475075
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.60132197
28DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59022137
29FLI1_27457419_Chip-Seq_LIVER_Mouse1.58927535
30CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.54229395
31MYC_18940864_ChIP-ChIP_HL60_Human1.54002148
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53305858
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.50642900
34RNF2_27304074_Chip-Seq_NSC_Mouse1.49097095
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48162217
36* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.48146800
37SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.44949349
38IRF1_19129219_ChIP-ChIP_H3396_Human1.44743533
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.42857277
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.42433092
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42287305
42MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42265269
43ZNF274_21170338_ChIP-Seq_K562_Hela1.41329220
44CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40771307
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38565835
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38433833
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.37558392
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36981718
49ER_23166858_ChIP-Seq_MCF-7_Human1.36510192
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35448605
51IGF1R_20145208_ChIP-Seq_DFB_Human1.35158254
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34756292
53CBP_20019798_ChIP-Seq_JUKART_Human1.34756292
54EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33283346
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31556590
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.30887184
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.29799217
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.29642204
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29514838
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28547039
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26495206
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25865675
63FUS_26573619_Chip-Seq_HEK293_Human1.25673280
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.23581323
65P300_19829295_ChIP-Seq_ESCs_Human1.22657118
66GABP_19822575_ChIP-Seq_HepG2_Human1.22466917
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.22146187
68KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21394563
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21116700
70TP53_22573176_ChIP-Seq_HFKS_Human1.21002381
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.20893407
72* SOX2_16153702_ChIP-ChIP_HESCs_Human1.20785071
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.20446631
74* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19400359
75AR_25329375_ChIP-Seq_VCAP_Human1.16563766
76MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15291457
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14523386
78KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.13784769
79TCF4_22108803_ChIP-Seq_LS180_Human1.13745086
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13521946
81* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13317115
82SMAD4_21799915_ChIP-Seq_A2780_Human1.12030529
83EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10716531
84RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10716531
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09338215
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09338215
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08162831
88* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08045937
89PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08017931
90* RUNX2_22187159_ChIP-Seq_PCA_Human1.07826237
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07172191
92SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.07034035
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.07028215
94REST_19997604_ChIP-ChIP_NEURONS_Mouse1.07002051
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.05693040
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05455234
97BCAT_22108803_ChIP-Seq_LS180_Human1.04286519
98DCP1A_22483619_ChIP-Seq_HELA_Human1.04140828
99SRF_21415370_ChIP-Seq_HL-1_Mouse1.03717063
100VDR_22108803_ChIP-Seq_LS180_Human1.03218015
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02722253
102* TCF4_23295773_ChIP-Seq_U87_Human1.02710050
103NANOG_19829295_ChIP-Seq_ESCs_Human1.01737226
104SOX2_19829295_ChIP-Seq_ESCs_Human1.01737226
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.99799863
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99487748
107EZH2_27294783_Chip-Seq_ESCs_Mouse0.99361275
108TTF2_22483619_ChIP-Seq_HELA_Human0.99013360
109PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98772653
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.98612249
111RNF2_27304074_Chip-Seq_ESCs_Mouse0.98484630
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98407387
113MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98390796
114SOX9_26525672_Chip-Seq_HEART_Mouse0.98007942
115ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97907087
116EED_16625203_ChIP-ChIP_MESCs_Mouse0.97829875
117E2F1_18555785_ChIP-Seq_MESCs_Mouse0.97559442
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96671062
119SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96466498
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96173526
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.96004377
122VDR_23849224_ChIP-Seq_CD4+_Human0.95313415
123NCOR_22424771_ChIP-Seq_293T_Human0.95313272
124FOXP3_21729870_ChIP-Seq_TREG_Human0.95114607
125MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94770825
126* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94393193
127TAL1_26923725_Chip-Seq_HPCs_Mouse0.94045125
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93902754
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93886488
130TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93377905
131PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93172534
132SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93087131
133SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92994455
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92815047
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92521820
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91414049
137JUN_21703547_ChIP-Seq_K562_Human0.91270439
138* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.90779407
139EZH2_27294783_Chip-Seq_NPCs_Mouse0.90738071
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.90572075
141OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90151993
142* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89677744
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88678024
144STAT3_23295773_ChIP-Seq_U87_Human0.86930837
145SMAD3_21741376_ChIP-Seq_EPCs_Human0.86610459
146ELK1_19687146_ChIP-ChIP_HELA_Human0.85651976

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction2.96401919
2MP0004270_analgesia2.94006856
3MP0002653_abnormal_ependyma_morphology2.89017013
4MP0003880_abnormal_central_pattern2.50024012
5MP0003123_paternal_imprinting2.43691032
6MP0000678_abnormal_parathyroid_gland2.40672395
7MP0004859_abnormal_synaptic_plasticity2.39956546
8MP0001529_abnormal_vocalization2.28996847
9MP0002734_abnormal_mechanical_nocicepti2.26434437
10MP0006292_abnormal_olfactory_placode2.25351987
11MP0003122_maternal_imprinting2.17344082
12MP0003635_abnormal_synaptic_transmissio2.05972758
13MP0008789_abnormal_olfactory_epithelium2.00864518
14MP0003787_abnormal_imprinting1.92881065
15MP0005394_taste/olfaction_phenotype1.91399273
16MP0005499_abnormal_olfactory_system1.91399273
17MP0001968_abnormal_touch/_nociception1.89630890
18MP0002184_abnormal_innervation1.87637673
19MP0005551_abnormal_eye_electrophysiolog1.77216742
20MP0003121_genomic_imprinting1.74618271
21MP0002063_abnormal_learning/memory/cond1.72285620
22MP0001293_anophthalmia1.70812257
23MP0002837_dystrophic_cardiac_calcinosis1.70143057
24MP0000778_abnormal_nervous_system1.65760019
25MP0005253_abnormal_eye_physiology1.64946614
26MP0005220_abnormal_exocrine_pancreas1.63758430
27MP0002572_abnormal_emotion/affect_behav1.62937014
28MP0003136_yellow_coat_color1.62367597
29MP0005646_abnormal_pituitary_gland1.60859686
30MP0002735_abnormal_chemical_nociception1.60760997
31MP0010386_abnormal_urinary_bladder1.58539795
32MP0009780_abnormal_chondrocyte_physiolo1.58216450
33MP0006276_abnormal_autonomic_nervous1.56702653
34MP0009046_muscle_twitch1.53902645
35MP0002557_abnormal_social/conspecific_i1.52715802
36MP0009745_abnormal_behavioral_response1.51103863
37MP0002736_abnormal_nociception_after1.50375357
38MP0003011_delayed_dark_adaptation1.49829178
39MP0001188_hyperpigmentation1.47448936
40MP0002272_abnormal_nervous_system1.47372358
41MP0008995_early_reproductive_senescence1.46871055
42MP0002693_abnormal_pancreas_physiology1.44692589
43MP0003879_abnormal_hair_cell1.44264180
44MP0003890_abnormal_embryonic-extraembry1.43763114
45MP0002064_seizures1.42568655
46MP0000631_abnormal_neuroendocrine_gland1.38882187
47MP0002638_abnormal_pupillary_reflex1.38756145
48MP0004043_abnormal_pH_regulation1.36622213
49MP0002876_abnormal_thyroid_physiology1.35465702
50MP0000013_abnormal_adipose_tissue1.32582968
51MP0005645_abnormal_hypothalamus_physiol1.32355092
52MP0002160_abnormal_reproductive_system1.32201182
53MP0003119_abnormal_digestive_system1.31577427
54MP0001944_abnormal_pancreas_morphology1.31161456
55MP0002067_abnormal_sensory_capabilities1.30074727
56MP0002909_abnormal_adrenal_gland1.30011345
57MP0001486_abnormal_startle_reflex1.27863239
58MP0001970_abnormal_pain_threshold1.27398630
59MP0008877_abnormal_DNA_methylation1.27267358
60MP0002733_abnormal_thermal_nociception1.26149745
61MP0006072_abnormal_retinal_apoptosis1.25904695
62MP0000955_abnormal_spinal_cord1.22664889
63MP0004924_abnormal_behavior1.21110155
64MP0005386_behavior/neurological_phenoty1.21110155
65MP0000372_irregular_coat_pigmentation1.20310377
66MP0003718_maternal_effect1.19857950
67MP0003942_abnormal_urinary_system1.17779590
68MP0001485_abnormal_pinna_reflex1.17424313
69MP0003283_abnormal_digestive_organ1.16103425
70MP0003693_abnormal_embryo_hatching1.15669190
71MP0002751_abnormal_autonomic_nervous1.15005161
72MP0003195_calcinosis1.14976012
73MP0003315_abnormal_perineum_morphology1.14202724
74MP0002822_catalepsy1.09814070
75MP0005195_abnormal_posterior_eye1.09215843
76MP0004145_abnormal_muscle_electrophysio1.08620543
77MP0004811_abnormal_neuron_physiology1.08096800
78MP0008058_abnormal_DNA_repair1.08025806
79MP0005187_abnormal_penis_morphology1.07416041
80MP0002882_abnormal_neuron_morphology1.06479756
81MP0000427_abnormal_hair_cycle1.06332608
82MP0005084_abnormal_gallbladder_morpholo1.06172385
83MP0002938_white_spotting1.04862548
84MP0001501_abnormal_sleep_pattern1.04628343
85MP0004142_abnormal_muscle_tone1.03402122
86MP0000566_synostosis1.01591231
87MP0005391_vision/eye_phenotype1.01490110
88MP0001905_abnormal_dopamine_level1.01312919
89MP0000026_abnormal_inner_ear1.00747317
90MP0005389_reproductive_system_phenotype0.97753728
91MP0002152_abnormal_brain_morphology0.97466469
92MP0004133_heterotaxia0.96058675
93MP0004885_abnormal_endolymph0.95720436
94MP0000049_abnormal_middle_ear0.95321067
95MP0001324_abnormal_eye_pigmentation0.94269820
96MP0001440_abnormal_grooming_behavior0.93955373
97MP0004147_increased_porphyrin_level0.93381412
98MP0001286_abnormal_eye_development0.92057873
99MP0005423_abnormal_somatic_nervous0.92042690
100MP0002752_abnormal_somatic_nervous0.91867323
101MP0003937_abnormal_limbs/digits/tail_de0.91786833
102MP0003861_abnormal_nervous_system0.91503741
103MP0000647_abnormal_sebaceous_gland0.90781707
104MP0001664_abnormal_digestion0.89866990
105MP0003183_abnormal_peptide_metabolism0.88852545
106MP0002234_abnormal_pharynx_morphology0.88424236
107MP0003938_abnormal_ear_development0.88174062
108MP0002090_abnormal_vision0.88088245
109MP0004957_abnormal_blastocyst_morpholog0.87638395
110MP0008932_abnormal_embryonic_tissue0.86783933
111MP0002102_abnormal_ear_morphology0.86530631
112MP0002233_abnormal_nose_morphology0.85455072
113MP0002066_abnormal_motor_capabilities/c0.85337782
114MP0001502_abnormal_circadian_rhythm0.85181897
115MP0001986_abnormal_taste_sensitivity0.85150890
116MP0003755_abnormal_palate_morphology0.84016366
117MP0010030_abnormal_orbit_morphology0.82017490
118MP0002095_abnormal_skin_pigmentation0.80339234
119MP0003567_abnormal_fetal_cardiomyocyte0.80201453
120MP0000681_abnormal_thyroid_gland0.79293797
121MP0005379_endocrine/exocrine_gland_phen0.78398864
122MP0000516_abnormal_urinary_system0.78272145
123MP0005367_renal/urinary_system_phenotyp0.78272145
124MP0003698_abnormal_male_reproductive0.77521330
125MP0002210_abnormal_sex_determination0.77347427
126MP0003786_premature_aging0.76713601
127MP0008872_abnormal_physiological_respon0.75891662
128MP0000534_abnormal_ureter_morphology0.75759506
129MP0001963_abnormal_hearing_physiology0.75747063
130MP0004085_abnormal_heartbeat0.75388200

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)3.88944349
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.66433240
3Focal motor seizures (HP:0011153)3.52827541
4Gait imbalance (HP:0002141)3.46300730
5Abnormal respiratory motile cilium physiology (HP:0012261)3.41417875
6Abnormal respiratory motile cilium morphology (HP:0005938)3.37932771
7Abnormal respiratory epithelium morphology (HP:0012253)3.37932771
8Severe visual impairment (HP:0001141)3.24624531
9Congenital primary aphakia (HP:0007707)3.20515756
10Pancreatic fibrosis (HP:0100732)3.19201501
11Chronic hepatic failure (HP:0100626)3.13910045
12Medial flaring of the eyebrow (HP:0010747)3.10089072
13Atonic seizures (HP:0010819)2.99896976
14Nephrogenic diabetes insipidus (HP:0009806)2.99725574
15Rhinitis (HP:0012384)2.92203230
16Papillary thyroid carcinoma (HP:0002895)2.91128715
17Bifid tongue (HP:0010297)2.89560372
18Abnormal pancreas size (HP:0012094)2.86279377
19Epileptic encephalopathy (HP:0200134)2.79448801
20Increased CSF lactate (HP:0002490)2.74720246
21Vaginal atresia (HP:0000148)2.74622654
22Type II lissencephaly (HP:0007260)2.74426329
23Genital tract atresia (HP:0001827)2.73310804
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.71380646
25True hermaphroditism (HP:0010459)2.64697418
26Hepatocellular necrosis (HP:0001404)2.61486282
27Poor coordination (HP:0002370)2.59664947
28Lipid accumulation in hepatocytes (HP:0006561)2.56772644
29Amblyopia (HP:0000646)2.55464745
30Tubulointerstitial nephritis (HP:0001970)2.53523333
31Aplasia/Hypoplasia of the tongue (HP:0010295)2.51684220
32Anencephaly (HP:0002323)2.51610703
33Pheochromocytoma (HP:0002666)2.50118895
34Lissencephaly (HP:0001339)2.47779168
35Sclerocornea (HP:0000647)2.47082672
36Molar tooth sign on MRI (HP:0002419)2.45974809
37Abnormality of midbrain morphology (HP:0002418)2.45974809
38Symptomatic seizures (HP:0011145)2.45226074
39Pancreatic cysts (HP:0001737)2.45078338
40Hepatic necrosis (HP:0002605)2.44844465
41Nephronophthisis (HP:0000090)2.44357986
42Increased hepatocellular lipid droplets (HP:0006565)2.44037030
43Acute necrotizing encephalopathy (HP:0006965)2.39137405
44Facial cleft (HP:0002006)2.38340444
45Limb dystonia (HP:0002451)2.35858450
46Intestinal atresia (HP:0011100)2.33880541
47Neuroendocrine neoplasm (HP:0100634)2.29660559
48Polyphagia (HP:0002591)2.29473952
49Abnormality of the renal cortex (HP:0011035)2.26571718
50Colon cancer (HP:0003003)2.26483797
51Hypothermia (HP:0002045)2.25515353
52Septo-optic dysplasia (HP:0100842)2.24304651
53Narrow forehead (HP:0000341)2.21639532
54Abnormal mitochondria in muscle tissue (HP:0008316)2.21339156
55Chronic bronchitis (HP:0004469)2.18738021
56Epileptiform EEG discharges (HP:0011182)2.18640129
57Retinal dysplasia (HP:0007973)2.17675753
58Unsteady gait (HP:0002317)2.16987930
59Hyperventilation (HP:0002883)2.14945844
60Cerebellar dysplasia (HP:0007033)2.13810182
61Myokymia (HP:0002411)2.11595630
62Focal seizures (HP:0007359)2.09222299
63Thyroid-stimulating hormone excess (HP:0002925)2.09217490
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.09155268
65Abnormality of calcium-phosphate metabolism (HP:0100530)2.08239676
663-Methylglutaconic aciduria (HP:0003535)2.08097289
67Febrile seizures (HP:0002373)2.08052475
68Hepatoblastoma (HP:0002884)2.07711324
69Supernumerary spleens (HP:0009799)2.05490771
70EEG with generalized epileptiform discharges (HP:0011198)2.04963854
71Preaxial hand polydactyly (HP:0001177)2.04924337
72Occipital encephalocele (HP:0002085)2.04770330
73Progressive cerebellar ataxia (HP:0002073)2.03986187
74Abnormal biliary tract physiology (HP:0012439)2.03128602
75Bile duct proliferation (HP:0001408)2.03128602
76Visual hallucinations (HP:0002367)2.02872385
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.02765565
78Absent/shortened dynein arms (HP:0200106)2.02765565
79Generalized aminoaciduria (HP:0002909)2.02681214
80Cerebral edema (HP:0002181)2.01486029
81Renal cortical cysts (HP:0000803)2.01374660
82Drooling (HP:0002307)2.00770257
83Broad distal phalanx of finger (HP:0009836)2.00671115
84Abnormality of the labia minora (HP:0012880)1.99055485
85Abnormal hair whorl (HP:0010721)1.98946147
86Gout (HP:0001997)1.97868966
87Hypsarrhythmia (HP:0002521)1.97201246
88Progressive macrocephaly (HP:0004481)1.97114871
89Abnormality of glycolysis (HP:0004366)1.96043610
90Increased serum pyruvate (HP:0003542)1.96043610
91Oligodactyly (hands) (HP:0001180)1.95980649
92Birth length less than 3rd percentile (HP:0003561)1.95750871
93Male pseudohermaphroditism (HP:0000037)1.94542377
94Aganglionic megacolon (HP:0002251)1.93804668
95Cystic liver disease (HP:0006706)1.92543436
96Absence seizures (HP:0002121)1.91841613
97Renal Fanconi syndrome (HP:0001994)1.91644379
98Congenital stationary night blindness (HP:0007642)1.89817233
99Cerebral hypomyelination (HP:0006808)1.89457843
100Anophthalmia (HP:0000528)1.89407515
101Dandy-Walker malformation (HP:0001305)1.89182653
102Broad foot (HP:0001769)1.88589054
103Thyroid carcinoma (HP:0002890)1.88455833
104Pachygyria (HP:0001302)1.88251971
105Absent eyebrow (HP:0002223)1.88083441
106Oculomotor apraxia (HP:0000657)1.84529916
107Aplasia/hypoplasia of the uterus (HP:0008684)1.83210414
108Optic disc pallor (HP:0000543)1.81837036
109Abnormality of dentin (HP:0010299)1.81435255
110Mitochondrial inheritance (HP:0001427)1.81386183
111Postaxial hand polydactyly (HP:0001162)1.81055355
112Abnormality of the renal medulla (HP:0100957)1.80643261
113Agitation (HP:0000713)1.80549474
114Pendular nystagmus (HP:0012043)1.80272022
115Aplasia/Hypoplasia of the lens (HP:0008063)1.79599803
116Cortical visual impairment (HP:0100704)1.79533014
117Specific learning disability (HP:0001328)1.78846433
118Degeneration of anterior horn cells (HP:0002398)1.78716027
119Abnormality of the anterior horn cell (HP:0006802)1.78716027
120Generalized tonic-clonic seizures (HP:0002069)1.77939684
121Hyperglycinemia (HP:0002154)1.77374270
122Acute encephalopathy (HP:0006846)1.77108623
123Poor suck (HP:0002033)1.76633849
124Growth hormone deficiency (HP:0000824)1.76469438
125Prominent nasal bridge (HP:0000426)1.74458834
126Increased serum lactate (HP:0002151)1.74375545
127Excessive salivation (HP:0003781)1.74161622
128Volvulus (HP:0002580)1.70715098
129Abnormality of alanine metabolism (HP:0010916)1.69748515
130Hyperalaninemia (HP:0003348)1.69748515
131Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.69748515
132Absent septum pellucidum (HP:0001331)1.69356135
133Decreased testicular size (HP:0008734)1.68421654
134Hypoplastic female external genitalia (HP:0012815)1.68303056
135Labial hypoplasia (HP:0000066)1.67938757
136Gastrointestinal atresia (HP:0002589)1.67618164
137Abolished electroretinogram (ERG) (HP:0000550)1.67298875
138Bicornuate uterus (HP:0000813)1.67271042
139Micropenis (HP:0000054)1.67130844
140Median cleft lip (HP:0000161)1.67117483
141Methylmalonic acidemia (HP:0002912)1.66893484
142Dialeptic seizures (HP:0011146)1.66696431
143Tubular atrophy (HP:0000092)1.66284007
144Multicystic kidney dysplasia (HP:0000003)1.65144264
145Optic nerve hypoplasia (HP:0000609)1.64163371
146Aplasia/Hypoplasia of the sternum (HP:0006714)1.62510422
147Postaxial foot polydactyly (HP:0001830)1.61186021
148Decreased circulating renin level (HP:0003351)1.61106598
149Delayed epiphyseal ossification (HP:0002663)1.60262006
150Tubulointerstitial abnormality (HP:0001969)1.59187305
151Atrophy/Degeneration involving motor neurons (HP:0007373)1.58173968
152Type I transferrin isoform profile (HP:0003642)1.57484883
153Congenital hepatic fibrosis (HP:0002612)1.57067890

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.06297969
2MAP3K42.99658245
3MAP4K22.92342575
4STK162.89346042
5MAPK152.79869080
6MARK12.79797996
7MAP2K72.74716869
8TRIM282.59526069
9AKT32.35515335
10NTRK32.17315334
11PASK2.10096089
12TNIK2.09950129
13ZAK2.07958347
14PLK21.97791539
15TSSK61.97306099
16CCNB11.95989323
17MAPK131.89424934
18NEK11.81776474
19PINK11.72368214
20GRK11.67960732
21NUAK11.67564053
22SRPK11.66213488
23DYRK21.64842880
24PLK31.63325072
25MINK11.61522231
26BRAF1.58598434
27INSRR1.56232132
28LATS21.55959036
29BRSK11.50303709
30PNCK1.47683587
31BUB11.42291547
32EPHA31.41206292
33BRSK21.39552250
34EPHA41.38055758
35VRK21.37741963
36PRKD31.35447898
37VRK11.33655874
38WNK31.29195660
39BCR1.27769824
40PAK31.26693582
41ARAF1.23353703
42NTRK21.19441160
43DAPK11.15574916
44CDK191.15331676
45PRKCG1.14509307
46MKNK21.14323364
47DYRK1A1.14217570
48DAPK21.14213472
49WEE11.13121053
50PLK41.10700628
51ERBB31.09454797
52STK391.08683162
53MUSK1.07736998
54PHKG21.06149390
55PHKG11.06149390
56STK38L1.06065627
57EPHB21.04227144
58OXSR11.03551069
59ACVR1B0.97695598
60GRK50.97219929
61UHMK10.95711729
62AURKA0.94493022
63CDC70.93601765
64NME10.87570257
65CDK30.86773262
66BMPR1B0.85185870
67PAK60.84980287
68MAP2K40.84977430
69PLK10.84222662
70PRPF4B0.83825526
71BMPR20.83635396
72MKNK10.83555917
73PDK40.82836029
74PDK30.82836029
75SGK4940.82611438
76SGK2230.82611438
77SGK20.81934268
78MST40.80616506
79CAMK2B0.77655708
80FRK0.77503107
81CDK50.75196516
82MAP3K120.74622400
83PRKCI0.74018986
84CAMKK20.70913638
85MAPKAPK50.68978691
86CSNK1G20.68471122
87TGFBR10.68114688
88SIK30.66777855
89PBK0.66285398
90SIK20.64758339
91CDK180.64519690
92STK240.64342911
93SCYL20.64318675
94EIF2AK30.64233560
95CDK140.64109252
96CDC42BPA0.63720604
97LIMK10.62882282
98CSNK1G30.61289819
99CAMK2A0.60046050
100MAP3K90.59892701
101CDK80.58979622
102TTK0.58220425
103KSR10.57228454
104FER0.56588355
105ATR0.56268429
106HIPK20.54409785
107CDK150.53719684
108RPS6KA20.53546557
109CHEK20.52291645
110CSNK1A1L0.50224429
111DYRK1B0.50002159
112PDK20.49380393
113CSNK1A10.48886150
114ATM0.47736036
115PRKCE0.47694315
116BCKDK0.46574545
117PKN10.45798328
118ADRBK20.45471908
119CDK11A0.45052094
120CAMK2D0.43391876
121PRKACA0.42601254
122CSNK1E0.41904872
123DYRK30.40735866
124NEK60.40491212
125CSNK1D0.40307088
126RPS6KB10.40266832
127CSNK1G10.39837133
128TIE10.39146123
129TAF10.38265796
130FGFR20.38170555
131WNK40.37592632
132CSNK2A10.36400644
133PRKACB0.36087462
134ADRBK10.33948368
135CSNK2A20.33388975

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.41918626
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.03987497
3Synaptic vesicle cycle_Homo sapiens_hsa047212.75071677
4Olfactory transduction_Homo sapiens_hsa047402.46322965
5Nicotine addiction_Homo sapiens_hsa050332.36656760
6Insulin secretion_Homo sapiens_hsa049112.36171678
7Collecting duct acid secretion_Homo sapiens_hsa049662.29352127
8Vibrio cholerae infection_Homo sapiens_hsa051102.27476324
9Oxidative phosphorylation_Homo sapiens_hsa001902.15534432
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14966213
11Proteasome_Homo sapiens_hsa030502.05755734
12RNA polymerase_Homo sapiens_hsa030201.95694803
13Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.94806878
14Propanoate metabolism_Homo sapiens_hsa006401.88079161
15Amphetamine addiction_Homo sapiens_hsa050311.79003838
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72293375
17Pancreatic secretion_Homo sapiens_hsa049721.71321322
18Parkinsons disease_Homo sapiens_hsa050121.69880869
19Huntingtons disease_Homo sapiens_hsa050161.67381950
20Taste transduction_Homo sapiens_hsa047421.64524869
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63258555
22GABAergic synapse_Homo sapiens_hsa047271.62175172
23Dopaminergic synapse_Homo sapiens_hsa047281.60756120
24Fanconi anemia pathway_Homo sapiens_hsa034601.58488769
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.57405874
26Circadian entrainment_Homo sapiens_hsa047131.54548297
27Long-term potentiation_Homo sapiens_hsa047201.48373168
28Oocyte meiosis_Homo sapiens_hsa041141.41845714
29Ribosome_Homo sapiens_hsa030101.40372256
30Basal transcription factors_Homo sapiens_hsa030221.40361873
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37937817
32Alzheimers disease_Homo sapiens_hsa050101.37418209
33Morphine addiction_Homo sapiens_hsa050321.36229276
34RNA transport_Homo sapiens_hsa030131.35776931
35Fatty acid elongation_Homo sapiens_hsa000621.33250654
36Glutamatergic synapse_Homo sapiens_hsa047241.29003830
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.28943969
38Regulation of autophagy_Homo sapiens_hsa041401.27006069
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25744877
40Nitrogen metabolism_Homo sapiens_hsa009101.20050569
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.18781670
42Cocaine addiction_Homo sapiens_hsa050301.18140671
43Serotonergic synapse_Homo sapiens_hsa047261.17023186
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17016936
45Peroxisome_Homo sapiens_hsa041461.16944893
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15441691
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.12633229
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12390897
49Cell cycle_Homo sapiens_hsa041101.11155598
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10526066
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09778602
52Linoleic acid metabolism_Homo sapiens_hsa005911.07962236
53Cysteine and methionine metabolism_Homo sapiens_hsa002701.07076028
54Spliceosome_Homo sapiens_hsa030401.03610590
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.02703763
56Ether lipid metabolism_Homo sapiens_hsa005651.02697121
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.00706115
58Nucleotide excision repair_Homo sapiens_hsa034200.99643068
59Caffeine metabolism_Homo sapiens_hsa002320.97506499
60N-Glycan biosynthesis_Homo sapiens_hsa005100.97177688
61Cholinergic synapse_Homo sapiens_hsa047250.96490809
62Cardiac muscle contraction_Homo sapiens_hsa042600.95962500
63Phototransduction_Homo sapiens_hsa047440.95665731
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95278711
65Selenocompound metabolism_Homo sapiens_hsa004500.95195446
66Pyrimidine metabolism_Homo sapiens_hsa002400.92226636
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.91732845
68SNARE interactions in vesicular transport_Homo sapiens_hsa041300.90832432
69Purine metabolism_Homo sapiens_hsa002300.90341653
70Calcium signaling pathway_Homo sapiens_hsa040200.89940207
71mRNA surveillance pathway_Homo sapiens_hsa030150.89733938
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89529290
73Steroid biosynthesis_Homo sapiens_hsa001000.86460811
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86178105
75Tryptophan metabolism_Homo sapiens_hsa003800.85942451
76Metabolic pathways_Homo sapiens_hsa011000.83351386
77Type II diabetes mellitus_Homo sapiens_hsa049300.81277388
78Fatty acid metabolism_Homo sapiens_hsa012120.80128723
79Basal cell carcinoma_Homo sapiens_hsa052170.79636397
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79345118
81Sulfur metabolism_Homo sapiens_hsa009200.77909631
82Circadian rhythm_Homo sapiens_hsa047100.76928208
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76327303
84Mismatch repair_Homo sapiens_hsa034300.75663067
85Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74585872
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74548490
87Folate biosynthesis_Homo sapiens_hsa007900.73071353
88Glutathione metabolism_Homo sapiens_hsa004800.71769314
89beta-Alanine metabolism_Homo sapiens_hsa004100.71545588
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70413273
91One carbon pool by folate_Homo sapiens_hsa006700.69199157
92Chemical carcinogenesis_Homo sapiens_hsa052040.66112683
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66078432
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65673310
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65238393
96Glucagon signaling pathway_Homo sapiens_hsa049220.65199849
97Salivary secretion_Homo sapiens_hsa049700.64373733
98GnRH signaling pathway_Homo sapiens_hsa049120.64036736
99Melanogenesis_Homo sapiens_hsa049160.63788753
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61475788
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.59838482
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59204588
103Hedgehog signaling pathway_Homo sapiens_hsa043400.59174529
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57577440
105Renin secretion_Homo sapiens_hsa049240.57553311
106Long-term depression_Homo sapiens_hsa047300.57352545
107Arginine and proline metabolism_Homo sapiens_hsa003300.57137302
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57088044
109Axon guidance_Homo sapiens_hsa043600.56724015
110Gap junction_Homo sapiens_hsa045400.55397368
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.55316876
112Gastric acid secretion_Homo sapiens_hsa049710.55297908
113cAMP signaling pathway_Homo sapiens_hsa040240.55266311
114Wnt signaling pathway_Homo sapiens_hsa043100.54142326
115Oxytocin signaling pathway_Homo sapiens_hsa049210.53585854
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53575308
117Retinol metabolism_Homo sapiens_hsa008300.53050458
118Estrogen signaling pathway_Homo sapiens_hsa049150.52150951
119Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51890750
120ErbB signaling pathway_Homo sapiens_hsa040120.51413516
121Protein digestion and absorption_Homo sapiens_hsa049740.51073118
122Fatty acid degradation_Homo sapiens_hsa000710.50153314
123Endometrial cancer_Homo sapiens_hsa052130.49740461
124RNA degradation_Homo sapiens_hsa030180.49734394
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49300615
126Vitamin B6 metabolism_Homo sapiens_hsa007500.47594446
127Pyruvate metabolism_Homo sapiens_hsa006200.46902144
128Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46346710
129Alcoholism_Homo sapiens_hsa050340.46069975
130Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45186022
131Non-homologous end-joining_Homo sapiens_hsa034500.44733975
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44527770
133Hippo signaling pathway_Homo sapiens_hsa043900.44131336
134Base excision repair_Homo sapiens_hsa034100.41553438
135Thyroid hormone synthesis_Homo sapiens_hsa049180.39709063
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.37518592
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.36031377
138Tight junction_Homo sapiens_hsa045300.35676065
139Colorectal cancer_Homo sapiens_hsa052100.35174223
140Homologous recombination_Homo sapiens_hsa034400.33896763
141Butanoate metabolism_Homo sapiens_hsa006500.32695732
142Epstein-Barr virus infection_Homo sapiens_hsa051690.32194236

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