FBXO17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by the F-box motif. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it contains an F-box domain. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.09632724
2proteasome assembly (GO:0043248)4.37510704
3peptidyl-glutamic acid carboxylation (GO:0017187)4.25442603
4protein carboxylation (GO:0018214)4.25442603
5L-phenylalanine metabolic process (GO:0006558)4.11006619
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.11006619
7L-phenylalanine catabolic process (GO:0006559)3.99506837
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.99506837
9sequestering of actin monomers (GO:0042989)3.73109472
10high-density lipoprotein particle remodeling (GO:0034375)3.69755239
11regulation of T-helper 1 cell differentiation (GO:0045625)3.50809223
12regulation of cholesterol esterification (GO:0010872)3.38480699
13cellular response to interferon-beta (GO:0035458)3.36627573
14reverse cholesterol transport (GO:0043691)3.35613308
15regulation of mitochondrial translation (GO:0070129)3.33642393
16regulation of fibrinolysis (GO:0051917)3.24011675
17L-serine metabolic process (GO:0006563)3.20989079
18formation of translation preinitiation complex (GO:0001731)3.14119765
19plasma lipoprotein particle assembly (GO:0034377)3.12496272
20serine family amino acid biosynthetic process (GO:0009070)3.11013213
21very-low-density lipoprotein particle assembly (GO:0034379)3.10956740
22regulation of plasminogen activation (GO:0010755)3.10792637
23negative regulation of fibrinolysis (GO:0051918)3.10471732
24antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.04022379
25plasma lipoprotein particle remodeling (GO:0034369)3.03191709
26protein-lipid complex remodeling (GO:0034368)3.03191709
27macromolecular complex remodeling (GO:0034367)3.03191709
28response to interferon-beta (GO:0035456)3.01807722
29glycine metabolic process (GO:0006544)3.00358305
30cholesterol efflux (GO:0033344)2.99002214
31ribosomal small subunit assembly (GO:0000028)2.98791286
32response to peptidoglycan (GO:0032494)2.98705498
33intestinal cholesterol absorption (GO:0030299)2.96580121
34negative regulation of viral genome replication (GO:0045071)2.96437761
35antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.95518284
36ribosome biogenesis (GO:0042254)2.92381391
37negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.90651348
38nephron tubule morphogenesis (GO:0072078)2.90471653
39nephron epithelium morphogenesis (GO:0072088)2.90471653
40mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.90408042
414-hydroxyproline metabolic process (GO:0019471)2.89201941
42regulation of protein activation cascade (GO:2000257)2.86814918
43proline metabolic process (GO:0006560)2.86250208
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84810193
45signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82974042
46signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82974042
47signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82974042
48positive regulation of actin filament depolymerization (GO:0030836)2.79604605
49signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.79545634
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.79545634
51peptidyl-histidine modification (GO:0018202)2.79402724
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.77097061
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.75568613
54protein-lipid complex assembly (GO:0065005)2.74350533
55positive regulation of T-helper cell differentiation (GO:0045624)2.73644791
56DNA double-strand break processing (GO:0000729)2.73388741
57regulation of complement activation (GO:0030449)2.72982800
58response to interferon-alpha (GO:0035455)2.72792985
59proline biosynthetic process (GO:0006561)2.72305908
60triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.72187075
61signal transduction involved in DNA integrity checkpoint (GO:0072401)2.71871817
62signal transduction involved in DNA damage checkpoint (GO:0072422)2.71871817
63positive regulation of natural killer cell differentiation (GO:0032825)2.71295188
64negative regulation of lipase activity (GO:0060192)2.69852507
65regulation of translational fidelity (GO:0006450)2.69547048
66signal transduction involved in cell cycle checkpoint (GO:0072395)2.69480815
67maturation of 5.8S rRNA (GO:0000460)2.68706379
68cullin deneddylation (GO:0010388)2.66157014
69regulation of T cell chemotaxis (GO:0010819)2.65943259
70positive regulation of T cell chemotaxis (GO:0010820)2.65943259
71anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.65712690
72positive regulation of defense response to virus by host (GO:0002230)2.64888856
73B cell mediated immunity (GO:0019724)2.59796224
74negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59024396
75negative regulation of ligase activity (GO:0051352)2.59024396
76neutrophil activation involved in immune response (GO:0002283)2.58634149
77triglyceride homeostasis (GO:0070328)2.57492924
78acylglycerol homeostasis (GO:0055090)2.57492924
79tetrahydrofolate metabolic process (GO:0046653)2.57106809
80protein deneddylation (GO:0000338)2.55742612
81regulation of dendritic cell antigen processing and presentation (GO:0002604)2.55471320
82DNA catabolic process, exonucleolytic (GO:0000738)2.54545046
83nephron tubule formation (GO:0072079)2.53959484
84base-excision repair, AP site formation (GO:0006285)2.53500070
85regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.53483893
86regulation of activation of Janus kinase activity (GO:0010533)2.53466477
87termination of RNA polymerase III transcription (GO:0006386)2.53019684
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.53019684
89cellular response to type I interferon (GO:0071357)2.51890533
90type I interferon signaling pathway (GO:0060337)2.51890533
91blood coagulation, intrinsic pathway (GO:0007597)2.50735616
92positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.48648477
93positive regulation of cell cycle arrest (GO:0071158)2.47799504
94response to type I interferon (GO:0034340)2.47630001
95positive regulation of T-helper 1 type immune response (GO:0002827)2.47603116
96ribonucleoprotein complex biogenesis (GO:0022613)2.47567290
97positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)2.47534728
98daunorubicin metabolic process (GO:0044597)2.47244113
99polyketide metabolic process (GO:0030638)2.47244113
100doxorubicin metabolic process (GO:0044598)2.47244113
101positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.46276641
102plasma lipoprotein particle clearance (GO:0034381)2.45287619
103antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.43942048
104serine family amino acid metabolic process (GO:0009069)2.43130510
105cellular response to interferon-alpha (GO:0035457)2.42023207
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.40996876
107plasma lipoprotein particle organization (GO:0071827)2.40336477
108regulation of cellular amino acid metabolic process (GO:0006521)2.40227728
109aldehyde catabolic process (GO:0046185)2.39694725
110DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.39393754
111DNA strand elongation involved in DNA replication (GO:0006271)2.37239944
112positive regulation of ligase activity (GO:0051351)2.37022340
113DNA replication checkpoint (GO:0000076)2.36498017
114ribosomal large subunit biogenesis (GO:0042273)2.35385855
115cochlea morphogenesis (GO:0090103)2.35373202
116kidney mesenchyme development (GO:0072074)2.34928901
117phospholipid efflux (GO:0033700)2.34337397
118telomere maintenance via semi-conservative replication (GO:0032201)2.33658287
119telomere maintenance via recombination (GO:0000722)2.32666310
120serine family amino acid catabolic process (GO:0009071)2.32051564
121endosome to pigment granule transport (GO:0043485)2.31890762
122endosome to melanosome transport (GO:0035646)2.31890762
123regulation of RIG-I signaling pathway (GO:0039535)2.31827311
124NIK/NF-kappaB signaling (GO:0038061)2.30216064
1257-methylguanosine mRNA capping (GO:0006370)2.29490008
126positive regulation of NF-kappaB import into nucleus (GO:0042346)2.29414636
127cellular response to exogenous dsRNA (GO:0071360)2.29270670
128negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.28177031
129DNA strand renaturation (GO:0000733)2.27842930
130pattern specification involved in kidney development (GO:0061004)2.27166916
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.27002225
132regulation of T-helper 1 type immune response (GO:0002825)2.24938847
133regulation of branching involved in ureteric bud morphogenesis (GO:0090189)2.24644975
134DNA strand elongation (GO:0022616)2.24622632
135positive regulation of viral genome replication (GO:0045070)2.24189974
136protein-lipid complex subunit organization (GO:0071825)2.23903031
137positive regulation of interleukin-12 production (GO:0032735)2.23198509
138RNA capping (GO:0036260)2.22903033
1397-methylguanosine RNA capping (GO:0009452)2.22903033
140pseudouridine synthesis (GO:0001522)2.22881713
141pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.22653567
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.22039260
143G1/S transition of mitotic cell cycle (GO:0000082)2.21666373
144cell cycle G1/S phase transition (GO:0044843)2.21666373
145regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.21502736
146DNA demethylation (GO:0080111)2.21390042
147aminoglycoside antibiotic metabolic process (GO:0030647)2.21112883
148natural killer cell mediated cytotoxicity (GO:0042267)2.20797075
149natural killer cell mediated immunity (GO:0002228)2.20797075
150dendritic cell chemotaxis (GO:0002407)2.20368927
151maturation of SSU-rRNA (GO:0030490)2.20077509
152glutamine family amino acid biosynthetic process (GO:0009084)2.19840480
153basement membrane organization (GO:0071711)2.19701392
154positive regulation of T cell migration (GO:2000406)2.19533121
155protein maturation by protein folding (GO:0022417)2.18578782
156regulation of protein heterodimerization activity (GO:0043497)2.18321316
157immunoglobulin mediated immune response (GO:0016064)2.17718595
158metanephric mesenchyme development (GO:0072075)2.17528358
159regulation of viral genome replication (GO:0045069)2.17383484
160leukocyte aggregation (GO:0070486)2.16521415
161heterochromatin organization (GO:0070828)2.16319159
162aromatic amino acid family catabolic process (GO:0009074)2.15765410
163mitotic metaphase plate congression (GO:0007080)2.14775642
164negative regulation of cholesterol transport (GO:0032375)2.13029683
165negative regulation of sterol transport (GO:0032372)2.13029683
166outer ear morphogenesis (GO:0042473)2.12204759
167peptidyl-proline hydroxylation (GO:0019511)2.11671185
168G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.10742748
169pteridine-containing compound metabolic process (GO:0042558)2.10659284
170fibrinolysis (GO:0042730)2.09929481
171L-ascorbic acid metabolic process (GO:0019852)2.09597167
172organ induction (GO:0001759)2.07843497
173pteridine-containing compound biosynthetic process (GO:0042559)2.05535041
174regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.05312762
175fatty acid homeostasis (GO:0055089)2.04746913
176embryonic skeletal joint morphogenesis (GO:0060272)2.03100739
177positive regulation of hormone metabolic process (GO:0032352)2.02747964
178renal tubule morphogenesis (GO:0061333)2.02009572
179cranial nerve morphogenesis (GO:0021602)2.00644442
180glomerular basement membrane development (GO:0032836)2.00106247
181ventricular cardiac muscle cell development (GO:0055015)2.00098301
182regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.98900565
183endothelial cell morphogenesis (GO:0001886)1.98690044
184paraxial mesoderm development (GO:0048339)1.97469735
185negative regulation of fatty acid biosynthetic process (GO:0045717)1.96378459
186cholesterol homeostasis (GO:0042632)1.94376415
187mitotic sister chromatid segregation (GO:0000070)1.94345590
188branched-chain amino acid catabolic process (GO:0009083)1.93399703
189positive regulation of mesonephros development (GO:0061213)1.93174065
190glutamate metabolic process (GO:0006536)1.92334623
191folic acid-containing compound metabolic process (GO:0006760)1.91766121
192protein hydroxylation (GO:0018126)1.91480580
193regulation of apoptotic cell clearance (GO:2000425)1.91214790
194sterol homeostasis (GO:0055092)1.91103671
195alpha-amino acid catabolic process (GO:1901606)1.90102599
196gluconeogenesis (GO:0006094)1.90028754
197regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)1.89506303
198glyoxylate metabolic process (GO:0046487)1.87175721
199peptidyl-glutamic acid modification (GO:0018200)1.87095996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.72627188
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.19048364
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.50436246
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40539816
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.21246833
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.14259173
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08348456
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00446477
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00384043
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.96507619
11* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81700750
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.73334771
13ESR1_15608294_ChIP-ChIP_MCF-7_Human2.68694049
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55932348
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.49712460
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47487167
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.46324881
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.35468319
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.33074962
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.24006502
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.23741877
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21571757
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18893667
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17934552
25RXR_22158963_ChIP-Seq_LIVER_Mouse2.14901295
26DCP1A_22483619_ChIP-Seq_HELA_Human2.13890063
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05463390
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04390220
29FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.04354570
30VDR_23849224_ChIP-Seq_CD4+_Human2.04216785
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99639919
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99556453
33E2F4_17652178_ChIP-ChIP_JURKAT_Human1.95102057
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87842861
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87715105
36TRIM28_21343339_ChIP-Seq_HEK293_Human1.87471010
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.87416884
38* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.86343645
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.85917552
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.85582675
41ELK1_19687146_ChIP-ChIP_HELA_Human1.81255021
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.80641040
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79825472
44AR_21909140_ChIP-Seq_LNCAP_Human1.78398440
45FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74274673
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.72804979
47PPARA_22158963_ChIP-Seq_LIVER_Mouse1.71226329
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.70835884
49FOXP3_21729870_ChIP-Seq_TREG_Human1.70660221
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69274393
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.68356666
52* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68160419
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67136172
54SPI1_23547873_ChIP-Seq_NB4_Human1.66952404
55GABP_19822575_ChIP-Seq_HepG2_Human1.66552755
56XRN2_22483619_ChIP-Seq_HELA_Human1.66429538
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.65592626
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65338533
59TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63840279
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63699505
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.63610672
62IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.61917197
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61743164
64TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60887151
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59983053
66YY1_21170310_ChIP-Seq_MESCs_Mouse1.56632036
67EGR1_19374776_ChIP-ChIP_THP-1_Human1.55465751
68HOXB4_20404135_ChIP-ChIP_EML_Mouse1.54189584
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.54085579
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.53700903
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47707760
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.42155208
73THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40083073
74EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39223274
75TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38992370
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.38560219
77LXR_22158963_ChIP-Seq_LIVER_Mouse1.36682816
78TTF2_22483619_ChIP-Seq_HELA_Human1.35444363
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.34248430
80MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.33678282
81TFEB_21752829_ChIP-Seq_HELA_Human1.33047808
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32789009
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31836016
84ELK1_22589737_ChIP-Seq_MCF10A_Human1.27785254
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27397548
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26984797
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26910174
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25252543
89SOX17_20123909_ChIP-Seq_XEN_Mouse1.24376477
90YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23901229
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.21960634
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21497907
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20688053
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.19826969
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18107890
96ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17531437
97HNF4A_19822575_ChIP-Seq_HepG2_Human1.12952073
98NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12806358
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11577735
100ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10691342
101MYB_26560356_Chip-Seq_TH2_Human1.09840267
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08647549
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08574030
104ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.08142566
105CLOCK_20551151_ChIP-Seq_293T_Human1.08138496
106CIITA_25753668_ChIP-Seq_RAJI_Human1.07993946
107EED_16625203_ChIP-ChIP_MESCs_Mouse1.07309168
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.04715140
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.04715140
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.04715140
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.01649726
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01424903
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00903318
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00857022
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99709520
116FOXP1_21924763_ChIP-Seq_HESCs_Human0.99535734
117MYB_26560356_Chip-Seq_TH1_Human0.99491483
118CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99045821
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98898249
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98300630
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97206480
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.96633125
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.96400504
124PU.1_20513432_ChIP-Seq_Bcells_Mouse0.95662104
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95594529
126ZNF263_19887448_ChIP-Seq_K562_Human0.95524746
127NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95350515
128SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95122956
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.94492405
130MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94181015
131* IRF8_27001747_Chip-Seq_BMDM_Mouse0.94015241
132* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93887466
133KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.93761788
134CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93722031
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.93602824
136* FOXA2_19822575_ChIP-Seq_HepG2_Human0.92749973
137TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92241520
138ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.91776611
139TP63_17297297_ChIP-ChIP_HaCaT_Human0.91739383
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91701669
141KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90007477
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.89975653
143ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89853336
144MYC_22102868_ChIP-Seq_BL_Human0.89764285
145* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89513320
146KDM5A_27292631_Chip-Seq_BREAST_Human0.89335161
147EOMES_21245162_ChIP-Seq_HESCs_Human0.88792799
148TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.88114693
149NANOG_21062744_ChIP-ChIP_HESCs_Human0.85668900
150ATF3_27146783_Chip-Seq_COLON_Human0.84849785
151THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83477757
152MYC_18940864_ChIP-ChIP_HL60_Human0.83385562
153SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82661034

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.20364464
2MP0001835_abnormal_antigen_presentation3.11733750
3MP0003693_abnormal_embryo_hatching2.83128072
4MP0000685_abnormal_immune_system2.66879330
5MP0004272_abnormal_basement_membrane2.53795500
6MP0005360_urolithiasis2.53663354
7MP0009785_altered_susceptibility_to2.50801206
8MP0002148_abnormal_hypersensitivity_rea2.47390948
9MP0008058_abnormal_DNA_repair2.40815890
10MP0005671_abnormal_response_to2.30985019
11MP0003195_calcinosis2.21561482
12MP0008057_abnormal_DNA_replication2.20027920
13MP0003436_decreased_susceptibility_to2.19754210
14MP0008007_abnormal_cellular_replicative2.18877664
15MP0008438_abnormal_cutaneous_collagen2.05895671
16MP0003077_abnormal_cell_cycle1.96124232
17MP0010094_abnormal_chromosome_stability1.95502580
18MP0005000_abnormal_immune_tolerance1.92245079
19MP0003763_abnormal_thymus_physiology1.90792119
20MP0010030_abnormal_orbit_morphology1.88943672
21MP0009333_abnormal_splenocyte_physiolog1.88741411
22MP0003786_premature_aging1.84433860
23MP0003111_abnormal_nucleus_morphology1.83570074
24MP0002277_abnormal_respiratory_mucosa1.81648003
25MP0006292_abnormal_olfactory_placode1.81591263
26MP0003122_maternal_imprinting1.80226174
27MP0009780_abnormal_chondrocyte_physiolo1.79216809
28MP0005365_abnormal_bile_salt1.77073049
29MP0002396_abnormal_hematopoietic_system1.76017039
30MP0010352_gastrointestinal_tract_polyps1.73318227
31MP0003283_abnormal_digestive_organ1.70240125
32MP0002249_abnormal_larynx_morphology1.69624331
33MP0010329_abnormal_lipoprotein_level1.67277922
34MP0001661_extended_life_span1.67158833
35MP0008875_abnormal_xenobiotic_pharmacok1.64491413
36MP0005025_abnormal_response_to1.63766086
37MP0000003_abnormal_adipose_tissue1.63469461
38MP0005332_abnormal_amino_acid1.63360424
39MP0002452_abnormal_antigen_presenting1.62316071
40MP0001348_abnormal_lacrimal_gland1.60159549
41MP0002723_abnormal_immune_serum1.59962659
42MP0001790_abnormal_immune_system1.58428433
43MP0005387_immune_system_phenotype1.58428433
44MP0004957_abnormal_blastocyst_morpholog1.56343116
45MP0000013_abnormal_adipose_tissue1.55791371
46MP0001819_abnormal_immune_cell1.54443796
47MP0008877_abnormal_DNA_methylation1.54273396
48MP0000858_altered_metastatic_potential1.54096598
49MP0005503_abnormal_tendon_morphology1.53876507
50MP0008932_abnormal_embryonic_tissue1.53265337
51MP0001853_heart_inflammation1.52340068
52MP0002877_abnormal_melanocyte_morpholog1.52061394
53MP0000566_synostosis1.51882944
54MP0002420_abnormal_adaptive_immunity1.51856652
55MP0001800_abnormal_humoral_immune1.50715075
56MP0002419_abnormal_innate_immunity1.50212796
57MP0005257_abnormal_intraocular_pressure1.47827194
58MP0009697_abnormal_copulation1.46889486
59MP0003724_increased_susceptibility_to1.46311939
60MP0002405_respiratory_system_inflammati1.44408985
61MP0003937_abnormal_limbs/digits/tail_de1.43327567
62MP0002398_abnormal_bone_marrow1.43236251
63MP0000678_abnormal_parathyroid_gland1.41651617
64MP0002132_abnormal_respiratory_system1.41556563
65MP0004808_abnormal_hematopoietic_stem1.40115664
66MP0010368_abnormal_lymphatic_system1.39543422
67MP0003941_abnormal_skin_development1.35417654
68MP0002697_abnormal_eye_size1.32870546
69MP0003385_abnormal_body_wall1.29574879
70MP0003136_yellow_coat_color1.28141913
71MP0005623_abnormal_meninges_morphology1.27967155
72MP0000490_abnormal_crypts_of1.27966734
73MP0003315_abnormal_perineum_morphology1.25773383
74MP0000716_abnormal_immune_system1.25274435
75MP0003279_aneurysm1.24915111
76MP0001299_abnormal_eye_distance/1.22228292
77MP0003252_abnormal_bile_duct1.20869950
78MP0005408_hypopigmentation1.19268056
79MP0005085_abnormal_gallbladder_physiolo1.19082095
80MP0005023_abnormal_wound_healing1.19050792
81MP0005397_hematopoietic_system_phenotyp1.14370737
82MP0001545_abnormal_hematopoietic_system1.14370737
83MP0006082_CNS_inflammation1.13970435
84MP0000534_abnormal_ureter_morphology1.13678798
85MP0001542_abnormal_bone_strength1.12291504
86MP0002722_abnormal_immune_system1.11727786
87MP0002163_abnormal_gland_morphology1.11715981
88MP0003186_abnormal_redox_activity1.11204201
89MP0004019_abnormal_vitamin_homeostasis1.10367425
90MP0000703_abnormal_thymus_morphology1.10172602
91MP0002233_abnormal_nose_morphology1.10038796
92MP0002429_abnormal_blood_cell1.09777058
93MP0009840_abnormal_foam_cell1.08598884
94MP0010307_abnormal_tumor_latency1.07310267
95MP0001270_distended_abdomen1.06876440
96MP0000639_abnormal_adrenal_gland1.06688098
97MP0000689_abnormal_spleen_morphology1.05998752
98MP0002933_joint_inflammation1.05679618
99MP0001286_abnormal_eye_development1.05002258
100MP0003755_abnormal_palate_morphology1.04808984
101MP0004133_heterotaxia1.03521959
102MP0001119_abnormal_female_reproductive1.01789561
103MP0002019_abnormal_tumor_incidence1.01469203
104MP0005187_abnormal_penis_morphology1.00711659
105MP0002160_abnormal_reproductive_system1.00403525
106MP0009384_cardiac_valve_regurgitation1.00386820
107MP0003448_altered_tumor_morphology0.99266385
108MP0003705_abnormal_hypodermis_morpholog0.98603440
109MP0001845_abnormal_inflammatory_respons0.98504582
110MP0005670_abnormal_white_adipose0.98303315
111MP0000537_abnormal_urethra_morphology0.97670138
112MP0005084_abnormal_gallbladder_morpholo0.97518166
113MP0000350_abnormal_cell_proliferation0.97361600
114MP0002876_abnormal_thyroid_physiology0.96656370
115MP0001533_abnormal_skeleton_physiology0.95755882
116MP0005310_abnormal_salivary_gland0.94663605
117MP0010155_abnormal_intestine_physiology0.94426480
118MP0005390_skeleton_phenotype0.94353231
119MP0004233_abnormal_muscle_weight0.94329273
120MP0009250_abnormal_appendicular_skeleto0.94218193
121MP0001293_anophthalmia0.92925592
122MP0002932_abnormal_joint_morphology0.92880026
123MP0001666_abnormal_nutrient_absorption0.92416817
124MP0000762_abnormal_tongue_morphology0.92178633
125MP0005171_absent_coat_pigmentation0.90740488
126MP0002295_abnormal_pulmonary_circulatio0.90056535
127MP0001879_abnormal_lymphatic_vessel0.89854954
128MP0005075_abnormal_melanosome_morpholog0.89811854
129MP0000015_abnormal_ear_pigmentation0.89332547
130MP0001346_abnormal_lacrimal_gland0.89080740
131MP0001944_abnormal_pancreas_morphology0.87166630
132MP0000313_abnormal_cell_death0.87020163
133MP0005076_abnormal_cell_differentiation0.85837925
134MP0008789_abnormal_olfactory_epithelium0.84162744
135MP0002006_tumorigenesis0.83378635
136MP0004947_skin_inflammation0.82905115
137MP0005275_abnormal_skin_tensile0.82692410
138MP0000681_abnormal_thyroid_gland0.82545513
139MP0005375_adipose_tissue_phenotype0.82283040
140MP0003567_abnormal_fetal_cardiomyocyte0.82069460
141MP0000049_abnormal_middle_ear0.81254096
142MP0008995_early_reproductive_senescence0.80545235
143MP0003119_abnormal_digestive_system0.80293562
144MP0009053_abnormal_anal_canal0.79636735
145MP0003868_abnormal_feces_composition0.79429991
146MP0001764_abnormal_homeostasis0.79162923
147MP0001958_emphysema0.79040378
148MP0003935_abnormal_craniofacial_develop0.77555788
149MP0002108_abnormal_muscle_morphology0.77118279
150MP0005389_reproductive_system_phenotype0.76965310
151MP0003879_abnormal_hair_cell0.76593740
152MP0002114_abnormal_axial_skeleton0.76213915
153MP0004782_abnormal_surfactant_physiolog0.75942249
154MP0002938_white_spotting0.75664708
155MP0003115_abnormal_respiratory_system0.75596730
156MP0001756_abnormal_urination0.75563017
157MP0002210_abnormal_sex_determination0.75494155
158MP0002234_abnormal_pharynx_morphology0.75152974
159MP0001243_abnormal_dermal_layer0.74975591
160MP0002092_abnormal_eye_morphology0.73748045
161MP0002085_abnormal_embryonic_tissue0.73517769
162MP0002111_abnormal_tail_morphology0.73161976
163MP0000627_abnormal_mammary_gland0.73141525
164MP0005508_abnormal_skeleton_morphology0.72644512
165MP0002282_abnormal_trachea_morphology0.72534928
166MP0002116_abnormal_craniofacial_bone0.72069368
167MP0004197_abnormal_fetal_growth/weight/0.71411549
168MP0000371_diluted_coat_color0.71040043
169MP0002751_abnormal_autonomic_nervous0.70365625
170MP0003123_paternal_imprinting0.70284291
171MP0005367_renal/urinary_system_phenotyp0.69287384
172MP0000516_abnormal_urinary_system0.69287384
173MP0000462_abnormal_digestive_system0.69147826
174MP0003942_abnormal_urinary_system0.69018562
175MP0002254_reproductive_system_inflammat0.68810280
176MP0000428_abnormal_craniofacial_morphol0.68678655
177MP0003950_abnormal_plasma_membrane0.68535658
178MP0001697_abnormal_embryo_size0.68388803

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)4.15256774
2Increased IgM level (HP:0003496)4.11342402
3Hypobetalipoproteinemia (HP:0003563)3.82531491
4Prolonged partial thromboplastin time (HP:0003645)3.81224763
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.79143653
6Vertebral compression fractures (HP:0002953)3.63038514
7Microretrognathia (HP:0000308)3.26151836
8Protrusio acetabuli (HP:0003179)3.25209609
9Biconcave vertebral bodies (HP:0004586)3.17822044
10Chromsome breakage (HP:0040012)3.13845088
11Elevated erythrocyte sedimentation rate (HP:0003565)3.11802436
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.02530098
13Distal arthrogryposis (HP:0005684)2.90709736
1411 pairs of ribs (HP:0000878)2.90676732
15Recurrent abscess formation (HP:0002722)2.86453740
16Eczematoid dermatitis (HP:0000976)2.85725983
17Hypolipoproteinemia (HP:0010981)2.85558106
18Myositis (HP:0100614)2.85107857
19Abnormality of dentin (HP:0010299)2.84597137
20Degeneration of anterior horn cells (HP:0002398)2.76691688
21Abnormality of the anterior horn cell (HP:0006802)2.76691688
22Type 2 muscle fiber atrophy (HP:0003554)2.73987657
23Cleft eyelid (HP:0000625)2.69761862
24Optic nerve coloboma (HP:0000588)2.68454509
25Trismus (HP:0000211)2.63435470
26Thrombocytosis (HP:0001894)2.60062257
27Vascular calcification (HP:0004934)2.52890075
28Birth length less than 3rd percentile (HP:0003561)2.45560810
29Muscle fiber atrophy (HP:0100295)2.45312028
30Breech presentation (HP:0001623)2.42292279
31Selective tooth agenesis (HP:0001592)2.41782756
32Cardiovascular calcification (HP:0011915)2.40971889
33Poor head control (HP:0002421)2.39478027
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.36968640
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.36968640
36Late onset (HP:0003584)2.36818419
37Orchitis (HP:0100796)2.34486388
38Joint hemorrhage (HP:0005261)2.34079298
39Hypercholesterolemia (HP:0003124)2.32133635
40Syringomyelia (HP:0003396)2.28083407
41Spinal cord lesions (HP:0100561)2.28083407
42Reticulocytopenia (HP:0001896)2.23709417
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23412780
44Hypoalphalipoproteinemia (HP:0003233)2.22360070
45Mediastinal lymphadenopathy (HP:0100721)2.22033952
46Abnormality of the common coagulation pathway (HP:0010990)2.21277679
47Hypoglycemic coma (HP:0001325)2.19952045
48Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19833091
49Abnormal ventriculo-arterial connection (HP:0011563)2.19753487
50Transposition of the great arteries (HP:0001669)2.19753487
51Abnormal connection of the cardiac segments (HP:0011545)2.19753487
52Abnormality of glycolysis (HP:0004366)2.18337320
53Patellar aplasia (HP:0006443)2.16158575
54Premature rupture of membranes (HP:0001788)2.16077104
55Optic neuritis (HP:0100653)2.14761614
56Retrobulbar optic neuritis (HP:0100654)2.14761614
57Recurrent bacterial skin infections (HP:0005406)2.14081929
58Gout (HP:0001997)2.11461106
59Coronal craniosynostosis (HP:0004440)2.09586338
60IgA deficiency (HP:0002720)2.08950322
61Nuclear cataract (HP:0100018)2.07263442
62Aplasia/Hypoplasia of the patella (HP:0006498)2.07233825
63Premature graying of hair (HP:0002216)2.06363265
64Meckel diverticulum (HP:0002245)2.05178674
65Hyperinsulinemic hypoglycemia (HP:0000825)2.05065526
66IgM deficiency (HP:0002850)2.04761060
67Hypoglycemic seizures (HP:0002173)2.01963258
68Type I transferrin isoform profile (HP:0003642)2.01796808
69Ulnar bowing (HP:0003031)2.01263854
70Petechiae (HP:0000967)2.01136945
71IgG deficiency (HP:0004315)2.00982102
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.00959158
73Vaginal fistula (HP:0004320)1.99797176
74Abnormality of the intrinsic pathway (HP:0010989)1.99073075
75Basal ganglia calcification (HP:0002135)1.97749825
76Abnormality of the ileum (HP:0001549)1.97074167
77Ectopic kidney (HP:0000086)1.96375224
78Unilateral renal agenesis (HP:0000122)1.95598863
79Xanthomatosis (HP:0000991)1.95241234
80Bicornuate uterus (HP:0000813)1.88415868
81Mitral stenosis (HP:0001718)1.88142150
82Facial cleft (HP:0002006)1.87972777
83Complement deficiency (HP:0004431)1.87071640
84Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.86434150
85Absent epiphyses (HP:0010577)1.86434150
86Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.86417259
87Fragile skin (HP:0001030)1.86286386
88Breast hypoplasia (HP:0003187)1.86092562
89Hypergammaglobulinemia (HP:0010702)1.85920744
90Aplastic anemia (HP:0001915)1.85762244
91Osteomalacia (HP:0002749)1.84272948
92Abnormality of methionine metabolism (HP:0010901)1.82120066
93Pulmonary fibrosis (HP:0002206)1.81314873
94Soft skin (HP:0000977)1.80829081
95Hyperglycinemia (HP:0002154)1.78109416
96Missing ribs (HP:0000921)1.78012305
97Renal duplication (HP:0000075)1.77829288
98Abnormality of macrophages (HP:0004311)1.77783033
99Recurrent skin infections (HP:0001581)1.77168961
100Periauricular skin pits (HP:0100277)1.76660383
101Preauricular pit (HP:0004467)1.76660383
102Abnormality of magnesium homeostasis (HP:0004921)1.76487898
103Hypomagnesemia (HP:0002917)1.76130708
104Short middle phalanx of the 5th finger (HP:0004220)1.76012533
105Cheilitis (HP:0100825)1.75485474
106Abnormal delivery (HP:0001787)1.74897687
107Abnormality of carpal bone ossification (HP:0006257)1.74622385
108Beaking of vertebral bodies (HP:0004568)1.74459022
109Mesomelia (HP:0003027)1.74134833
110Partial duplication of thumb phalanx (HP:0009944)1.72729012
111Enlarged kidneys (HP:0000105)1.72598207
112Abnormality of T cell physiology (HP:0011840)1.72365199
113Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71992698
114Abnormality of the renal collecting system (HP:0004742)1.70636578
115Short nail (HP:0001799)1.70147249
116Abnormal lung lobation (HP:0002101)1.70138246
117Myelodysplasia (HP:0002863)1.69977306
118Rough bone trabeculation (HP:0100670)1.69032296
119Granulocytopenia (HP:0001913)1.68448970
120Vasculitis (HP:0002633)1.68327608
121Congenital malformation of the right heart (HP:0011723)1.68257068
122Double outlet right ventricle (HP:0001719)1.68257068
123Abnormality of the preputium (HP:0100587)1.68227146
124Partial duplication of the phalanx of hand (HP:0009999)1.67791692
125Absent thumb (HP:0009777)1.67791485
126Abnormality of T cells (HP:0002843)1.67551934
127True hermaphroditism (HP:0010459)1.67549528
128Recurrent pneumonia (HP:0006532)1.66402497
129Abnormality of the calcaneus (HP:0008364)1.66130881
130Recurrent fungal infections (HP:0002841)1.65699155
131Cervical subluxation (HP:0003308)1.65653492
132Hypophosphatemic rickets (HP:0004912)1.65418975
133Amaurosis fugax (HP:0100576)1.65397353
134Increased serum pyruvate (HP:0003542)1.65097991
135Gingivitis (HP:0000230)1.64920299
136Lymphoma (HP:0002665)1.64440967
137Prominent metopic ridge (HP:0005487)1.63428410
138Hepatoblastoma (HP:0002884)1.63347842
139Pancreatic islet-cell hyperplasia (HP:0004510)1.63121845
140Rectal prolapse (HP:0002035)1.62208849
141Focal segmental glomerulosclerosis (HP:0000097)1.61667997
142Bifid tongue (HP:0010297)1.61413460
143Duplication of thumb phalanx (HP:0009942)1.60879569
144Slender long bone (HP:0003100)1.59787434
145Pterygium (HP:0001059)1.59287137
146Patent foramen ovale (HP:0001655)1.58656025
147Abnormal gallbladder physiology (HP:0012438)1.57886620
148Cholecystitis (HP:0001082)1.57886620
149Concave nail (HP:0001598)1.57765749
150Occipital encephalocele (HP:0002085)1.57606580
151Abnormality of the duodenum (HP:0002246)1.57525949
152Myopathic facies (HP:0002058)1.57064652
153Recurrent lower respiratory tract infections (HP:0002783)1.56564382
154Abnormal number of incisors (HP:0011064)1.56491494
155Bone marrow hypocellularity (HP:0005528)1.56139046
156Abnormality of eosinophils (HP:0001879)1.56071496
157Decreased skull ossification (HP:0004331)1.55849168
158Delayed cranial suture closure (HP:0000270)1.55834514
159Sparse eyelashes (HP:0000653)1.55567620
160Rectal fistula (HP:0100590)1.54907418
161Rectovaginal fistula (HP:0000143)1.54907418
162Multiple enchondromatosis (HP:0005701)1.54476261
163Clubbing of toes (HP:0100760)1.54351862
164Abnormal tarsal ossification (HP:0008369)1.54262776
165Duplicated collecting system (HP:0000081)1.54220846
166Abnormal glycosylation (HP:0012345)1.53570550
167Spontaneous abortion (HP:0005268)1.53416767
168Entropion (HP:0000621)1.52509170
169Proximal tubulopathy (HP:0000114)1.51711110
170Alacrima (HP:0000522)1.51684953
171Neonatal short-limb short stature (HP:0008921)1.50586840
172Delayed CNS myelination (HP:0002188)1.50403604
173Horseshoe kidney (HP:0000085)1.46675574
174Bifid scrotum (HP:0000048)1.46477250
175Hyperphosphaturia (HP:0003109)1.44811460
176Potter facies (HP:0002009)1.44350029
177Facial shape deformation (HP:0011334)1.44350029
178Abnormality of the nasal septum (HP:0000419)1.44333162
179Abnormality of pain sensation (HP:0010832)1.43516429
180Impaired pain sensation (HP:0007328)1.43516429
181Abnormality of complement system (HP:0005339)1.43360068
182Abnormality of the pancreatic islet cells (HP:0006476)1.43333857
183Abnormality of endocrine pancreas physiology (HP:0012093)1.43333857
184Increased nuchal translucency (HP:0010880)1.42527326
185Shallow orbits (HP:0000586)1.39402166
186Stage 5 chronic kidney disease (HP:0003774)1.39148897
187Turricephaly (HP:0000262)1.38947474
188Intrahepatic cholestasis (HP:0001406)1.38409732
189Hyperextensible skin (HP:0000974)1.38014164

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.42674568
2TESK13.81500521
3SRPK13.80625751
4TESK23.42792544
5EIF2AK13.28690580
6PIM23.02202387
7BUB12.64141935
8NME22.48430455
9LIMK12.37799573
10MAP3K142.36379202
11VRK22.31009295
12ZAK2.09595593
13BLK2.07114751
14TXK2.03270447
15FGFR21.96596392
16STK161.91913286
17IRAK31.91394016
18ZAP701.84467627
19PLK41.81814514
20WNK41.75958667
21NEK11.72427872
22IKBKB1.69038884
23ERBB31.65896162
24IRAK41.65608957
25RPS6KA41.65282704
26JAK31.62533272
27BCKDK1.59297217
28SIK31.57682499
29LATS11.55845525
30MAP4K11.55691615
31CDC71.51204480
32ICK1.49345217
33ILK1.47008263
34FGFR41.45370109
35EIF2AK31.42954508
36EEF2K1.40289278
37PTK21.37292068
38EPHA21.36996881
39PDGFRA1.36732348
40PASK1.35921798
41EIF2AK21.35649953
42FLT31.35357722
43WEE11.35052114
44CHUK1.31556725
45STK38L1.31276258
46BMPR21.31150749
47ACVR1B1.26919838
48MAP3K111.25230374
49PKN21.20958139
50TBK11.20653841
51PIM11.20498243
52CDK71.19518835
53IKBKE1.18716777
54TGFBR11.14407074
55PRKD31.14086897
56TLK11.13383790
57NEK91.12795365
58SMG11.10785360
59MET1.08619946
60TRPM71.08535560
61TEC1.07620070
62FGFR11.07112946
63PBK1.03439756
64ATR1.01021537
65ERBB41.00213716
66MAP4K20.99984398
67NTRK30.99982690
68LATS20.98759323
69KDR0.98725993
70MAP2K60.97679661
71MAP3K120.95742989
72TYK20.95741368
73EPHB20.94503033
74MAP3K20.93393528
75WNK30.92509951
76BTK0.92291413
77TAF10.87409444
78BMPR1B0.87032456
79FRK0.86290017
80PHKG10.86229915
81PHKG20.86229915
82PNCK0.85970373
83CDK120.85515657
84PLK10.85222635
85NUAK10.84579632
86BRSK20.84549661
87MYLK0.83170456
88PIK3CG0.82551267
89YES10.80401521
90MKNK10.80209890
91CSNK1G10.79169029
92STK40.77626985
93MELK0.76732358
94MKNK20.76011109
95PAK20.74423490
96NTRK10.73404143
97STK380.73344390
98MARK30.72583121
99PAK40.72260274
100PDK20.71187763
101ADRBK20.69155851
102AURKB0.66488205
103MAPK110.66486772
104TRIM280.66461724
105AKT20.66381090
106STK30.65333181
107NEK20.64979170
108RPS6KB20.64142667
109MTOR0.62904083
110CSNK1G30.62856040
111NLK0.62539654
112TTK0.61579712
113STK100.59411790
114CSNK1E0.57610146
115CHEK20.57408142
116EPHA40.55524808
117CSNK1A1L0.54968824
118CAMK1G0.54709031
119PRKAA20.54237998
120TAOK20.53949399
121VRK10.53625209
122GRK10.53378556
123ATM0.53260341
124BRAF0.51847568
125CDK80.51769031
126SYK0.51315787
127TSSK60.51182430
128LYN0.51124919
129PRKAA10.50893201
130IRAK10.50810455
131CDK90.50589819
132KIT0.50577111
133MOS0.50377232
134CDK10.50019334
135PLK20.48989516
136DAPK30.48282504
137DDR20.47005906
138GSK3A0.46999512
139MAPKAPK30.46890313
140INSRR0.46782231
141DYRK30.44330802
142JAK10.44094228
143PLK30.42790789
144CSNK2A10.39112466
145MUSK0.37940701
146EPHA30.37629865
147MAP2K30.36560713
148CHEK10.34805234
149BRSK10.34189103
150ABL20.33993670
151NME10.33887936
152ITK0.33564056
153MAP3K80.33152449
154AURKA0.33040185
155MAP3K30.32989104
156DYRK20.32826752
157LCK0.32319037
158MAPKAPK20.31601952

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.36920466
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.77280991
3RNA polymerase_Homo sapiens_hsa030202.51430811
4DNA replication_Homo sapiens_hsa030302.45836168
5Base excision repair_Homo sapiens_hsa034102.43042094
6Allograft rejection_Homo sapiens_hsa053302.40901675
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.34895667
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.13218347
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.07867269
10Homologous recombination_Homo sapiens_hsa034402.04007818
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.01866791
12Mismatch repair_Homo sapiens_hsa034301.99817162
13Complement and coagulation cascades_Homo sapiens_hsa046101.98749970
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96951009
15Sulfur relay system_Homo sapiens_hsa041221.93722978
16Graft-versus-host disease_Homo sapiens_hsa053321.92653980
17Ribosome_Homo sapiens_hsa030101.91081227
18Vitamin B6 metabolism_Homo sapiens_hsa007501.87118061
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86069204
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.85653242
21Spliceosome_Homo sapiens_hsa030401.81021861
22Protein export_Homo sapiens_hsa030601.77465363
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73909607
24Legionellosis_Homo sapiens_hsa051341.71769607
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.70269501
26Pyrimidine metabolism_Homo sapiens_hsa002401.70092075
27RNA transport_Homo sapiens_hsa030131.69148360
28p53 signaling pathway_Homo sapiens_hsa041151.68302165
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64818495
30Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.64771164
31Measles_Homo sapiens_hsa051621.64194347
32Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60787724
33Herpes simplex infection_Homo sapiens_hsa051681.60442925
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.58310351
35Biosynthesis of amino acids_Homo sapiens_hsa012301.58171618
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56018013
37Primary immunodeficiency_Homo sapiens_hsa053401.54202297
38Autoimmune thyroid disease_Homo sapiens_hsa053201.53345363
39One carbon pool by folate_Homo sapiens_hsa006701.51730624
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50715857
41Arginine and proline metabolism_Homo sapiens_hsa003301.49112140
42Cell cycle_Homo sapiens_hsa041101.48349848
43Pyruvate metabolism_Homo sapiens_hsa006201.45753238
44Fatty acid elongation_Homo sapiens_hsa000621.45414242
45Arginine biosynthesis_Homo sapiens_hsa002201.44035354
46Leishmaniasis_Homo sapiens_hsa051401.44009284
47Type I diabetes mellitus_Homo sapiens_hsa049401.43985819
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43059121
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42900230
50Butanoate metabolism_Homo sapiens_hsa006501.40906158
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39118181
52RNA degradation_Homo sapiens_hsa030181.38124437
53Fanconi anemia pathway_Homo sapiens_hsa034601.37708921
54Nucleotide excision repair_Homo sapiens_hsa034201.35858241
55RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.34635479
56NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34441996
57Primary bile acid biosynthesis_Homo sapiens_hsa001201.33818767
58Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32427930
59Propanoate metabolism_Homo sapiens_hsa006401.29294989
60Fatty acid degradation_Homo sapiens_hsa000711.29050389
61Folate biosynthesis_Homo sapiens_hsa007901.28729839
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27344237
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26976390
64Shigellosis_Homo sapiens_hsa051311.26734108
65Selenocompound metabolism_Homo sapiens_hsa004501.25886621
66Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.25227408
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.25045951
68Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24104545
69Carbon metabolism_Homo sapiens_hsa012001.23387419
70Fat digestion and absorption_Homo sapiens_hsa049751.22946329
71Basal transcription factors_Homo sapiens_hsa030221.22876511
72Steroid biosynthesis_Homo sapiens_hsa001001.22504532
73Fructose and mannose metabolism_Homo sapiens_hsa000511.21571942
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20619998
75Viral myocarditis_Homo sapiens_hsa054161.20430113
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19953380
77Retinol metabolism_Homo sapiens_hsa008301.18549420
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18034127
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.17846482
80Epstein-Barr virus infection_Homo sapiens_hsa051691.17055223
81Lysine degradation_Homo sapiens_hsa003101.15952173
82Phenylalanine metabolism_Homo sapiens_hsa003601.12657904
83Malaria_Homo sapiens_hsa051441.11942479
84Influenza A_Homo sapiens_hsa051641.11534422
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10289792
86Antigen processing and presentation_Homo sapiens_hsa046121.09011138
87Asthma_Homo sapiens_hsa053101.08574776
88Non-homologous end-joining_Homo sapiens_hsa034501.05894832
89Fatty acid metabolism_Homo sapiens_hsa012121.05452879
90Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04391381
91Vitamin digestion and absorption_Homo sapiens_hsa049771.03817945
92Apoptosis_Homo sapiens_hsa042101.03589990
93Rheumatoid arthritis_Homo sapiens_hsa053231.03469846
94Hematopoietic cell lineage_Homo sapiens_hsa046401.03375073
95Chemical carcinogenesis_Homo sapiens_hsa052041.02613643
96Steroid hormone biosynthesis_Homo sapiens_hsa001401.00662543
97Starch and sucrose metabolism_Homo sapiens_hsa005001.00481788
98Tyrosine metabolism_Homo sapiens_hsa003500.99149373
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.99070437
100Other glycan degradation_Homo sapiens_hsa005110.98516289
101TNF signaling pathway_Homo sapiens_hsa046680.98357459
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.98284281
103Sulfur metabolism_Homo sapiens_hsa009200.98235924
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.95525574
105Tryptophan metabolism_Homo sapiens_hsa003800.90365555
106beta-Alanine metabolism_Homo sapiens_hsa004100.88170830
107Histidine metabolism_Homo sapiens_hsa003400.84945840
108Purine metabolism_Homo sapiens_hsa002300.80382760
109Basal cell carcinoma_Homo sapiens_hsa052170.80223761
110Pertussis_Homo sapiens_hsa051330.79029347
111Toxoplasmosis_Homo sapiens_hsa051450.77063801
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76601318
113Metabolic pathways_Homo sapiens_hsa011000.75493430
114HTLV-I infection_Homo sapiens_hsa051660.75074065
115Oxidative phosphorylation_Homo sapiens_hsa001900.75052573
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74158909
117Hepatitis B_Homo sapiens_hsa051610.74104857
118PPAR signaling pathway_Homo sapiens_hsa033200.73318196
119Peroxisome_Homo sapiens_hsa041460.72855021
120Bile secretion_Homo sapiens_hsa049760.70406027
121Viral carcinogenesis_Homo sapiens_hsa052030.70162803
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68297998
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67770750
124Tuberculosis_Homo sapiens_hsa051520.64306901
125ECM-receptor interaction_Homo sapiens_hsa045120.64272018
126Hedgehog signaling pathway_Homo sapiens_hsa043400.63005998
127Phagosome_Homo sapiens_hsa041450.60821162
128Glucagon signaling pathway_Homo sapiens_hsa049220.58551815
129mRNA surveillance pathway_Homo sapiens_hsa030150.57587378
130Parkinsons disease_Homo sapiens_hsa050120.57239229
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57149706
132Osteoclast differentiation_Homo sapiens_hsa043800.56956401
133Huntingtons disease_Homo sapiens_hsa050160.56260985
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.53422727
135Salmonella infection_Homo sapiens_hsa051320.53369176
136Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.52879948
137TGF-beta signaling pathway_Homo sapiens_hsa043500.52096755
138Arachidonic acid metabolism_Homo sapiens_hsa005900.51317985
139Chemokine signaling pathway_Homo sapiens_hsa040620.49839130
140ABC transporters_Homo sapiens_hsa020100.49568534
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48809280
142T cell receptor signaling pathway_Homo sapiens_hsa046600.48607858
143MicroRNAs in cancer_Homo sapiens_hsa052060.48211556
144Acute myeloid leukemia_Homo sapiens_hsa052210.48134956
145AMPK signaling pathway_Homo sapiens_hsa041520.45851631
146Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45135653
147Thyroid cancer_Homo sapiens_hsa052160.44729322
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44264014
149Galactose metabolism_Homo sapiens_hsa000520.43421683
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.42594399
151Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41830657
152Nitrogen metabolism_Homo sapiens_hsa009100.41785367
153Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38896300
154Prolactin signaling pathway_Homo sapiens_hsa049170.37944291
155Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36965180
156Leukocyte transendothelial migration_Homo sapiens_hsa046700.36809378
157Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36734659
158Small cell lung cancer_Homo sapiens_hsa052220.36732448
159Cysteine and methionine metabolism_Homo sapiens_hsa002700.36703901
160Glutathione metabolism_Homo sapiens_hsa004800.36139840
161Regulation of autophagy_Homo sapiens_hsa041400.34867718
162African trypanosomiasis_Homo sapiens_hsa051430.33707758
163Adherens junction_Homo sapiens_hsa045200.32465125
164N-Glycan biosynthesis_Homo sapiens_hsa005100.30859862
165Hippo signaling pathway_Homo sapiens_hsa043900.29670449
166Notch signaling pathway_Homo sapiens_hsa043300.29450174
167Pentose phosphate pathway_Homo sapiens_hsa000300.27547831
168HIF-1 signaling pathway_Homo sapiens_hsa040660.27371154
169Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.26985809
170PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26005057

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