FBXO18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.95892393
2COPI coating of Golgi vesicle (GO:0048205)4.95892393
3positive regulation of gamma-delta T cell activation (GO:0046645)4.38434827
4positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.25831519
5negative regulation of erythrocyte differentiation (GO:0045647)4.04419025
6protein heterotrimerization (GO:0070208)3.84172588
7tolerance induction (GO:0002507)3.80368430
8plasma membrane repair (GO:0001778)3.68904927
9actin filament depolymerization (GO:0030042)3.62746186
10cell communication by electrical coupling (GO:0010644)3.59408051
11cardiac myofibril assembly (GO:0055003)3.58218035
12regulation of translational fidelity (GO:0006450)3.58114288
13cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57137162
14apoptotic cell clearance (GO:0043277)3.56937598
15peptidyl-lysine dimethylation (GO:0018027)3.52700298
16mannose metabolic process (GO:0006013)3.43048658
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.30419366
18tricarboxylic acid cycle (GO:0006099)3.27971384
19regulation of gamma-delta T cell differentiation (GO:0045586)3.27867375
20antigen processing and presentation via MHC class Ib (GO:0002475)3.27145643
21positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.25949702
22negative regulation of cell size (GO:0045792)3.25804461
23positive regulation of glycogen biosynthetic process (GO:0045725)3.23254482
24negative regulation of sodium ion transport (GO:0010766)3.18830651
25sodium ion export (GO:0071436)3.14389016
26embryonic foregut morphogenesis (GO:0048617)3.12760176
27regulation of gamma-delta T cell activation (GO:0046643)3.10961489
28regulation of type I interferon-mediated signaling pathway (GO:0060338)3.10586059
29establishment of nucleus localization (GO:0040023)3.08800215
30cellular response to virus (GO:0098586)3.06772380
31regulation of glucose import in response to insulin stimulus (GO:2001273)3.06695100
32B cell receptor signaling pathway (GO:0050853)3.05054480
33insulin-like growth factor receptor signaling pathway (GO:0048009)3.01693083
34pinocytosis (GO:0006907)2.99195393
35growth hormone receptor signaling pathway (GO:0060396)2.99021406
36antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.98830247
37regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.96217236
38positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.93950793
39cell-substrate junction assembly (GO:0007044)2.93519573
40tricarboxylic acid metabolic process (GO:0072350)2.93237514
41morphogenesis of an endothelium (GO:0003159)2.91788334
42endothelial tube morphogenesis (GO:0061154)2.91788334
43negative regulation of potassium ion transmembrane transport (GO:1901380)2.90857987
443-UTR-mediated mRNA stabilization (GO:0070935)2.89083000
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88794729
46protein localization to endosome (GO:0036010)2.86821157
47vascular endothelial growth factor signaling pathway (GO:0038084)2.84315035
48adherens junction assembly (GO:0034333)2.84203153
49antigen processing and presentation of endogenous antigen (GO:0019883)2.83561787
50alanine transport (GO:0032328)2.80883264
51proline transport (GO:0015824)2.80872870
52positive regulation of fatty acid oxidation (GO:0046321)2.79266353
53glial cell proliferation (GO:0014009)2.78750359
54paraxial mesoderm development (GO:0048339)2.78542958
55epithelial cell-cell adhesion (GO:0090136)2.78528477
56stress fiber assembly (GO:0043149)2.75919913
57positive regulation of receptor recycling (GO:0001921)2.74359051
58activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.72658590
59negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71563512
60positive regulation of Cdc42 GTPase activity (GO:0043089)2.70618524
61dorsal/ventral axis specification (GO:0009950)2.70014687
62regulation of nucleobase-containing compound transport (GO:0032239)2.69498212
63activation of protein kinase A activity (GO:0034199)2.67188898
64apoptotic process involved in morphogenesis (GO:0060561)2.66616389
65regulation of fatty acid beta-oxidation (GO:0031998)2.63558061
66cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.62833557
67regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.62384481
68regulation of necroptotic process (GO:0060544)2.61801993
69negative regulation of TOR signaling (GO:0032007)2.61010851
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.60972186
71histone H3-K36 demethylation (GO:0070544)2.60320118
72layer formation in cerebral cortex (GO:0021819)2.59417381
73negative regulation of toll-like receptor signaling pathway (GO:0034122)2.59402860
74regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.59328713
75regulation of fatty acid oxidation (GO:0046320)2.58630003
76positive regulation of nuclease activity (GO:0032075)2.58292827
77negative regulation of skeletal muscle tissue development (GO:0048642)2.57561185
78positive regulation of fatty acid beta-oxidation (GO:0032000)2.57538997
79response to laminar fluid shear stress (GO:0034616)2.57171775
80necroptotic process (GO:0070266)2.56639485
81cellular zinc ion homeostasis (GO:0006882)2.56171689
82regulation of defense response to virus by virus (GO:0050690)2.55479253
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.55321341
84protein hydroxylation (GO:0018126)2.54855258
85platelet formation (GO:0030220)2.54759817
86regulation of tight junction assembly (GO:2000810)2.54406365
87cellular response to growth hormone stimulus (GO:0071378)2.54138856
88negative regulation of myotube differentiation (GO:0010832)2.53692940
89negative regulation of fatty acid transport (GO:2000192)2.52558773
90skin morphogenesis (GO:0043589)2.51914195
91regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.51839727
92basement membrane organization (GO:0071711)2.51332910
93carnitine shuttle (GO:0006853)2.51271817
94cell communication involved in cardiac conduction (GO:0086065)2.50361644
95protein carboxylation (GO:0018214)2.49740578
96peptidyl-glutamic acid carboxylation (GO:0017187)2.49740578
97cardiac muscle contraction (GO:0060048)2.49709232
98protein localization to cell surface (GO:0034394)2.48471769
99regulation of p38MAPK cascade (GO:1900744)2.48315487
100positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.48281532
101growth hormone secretion (GO:0030252)2.47848081
102regulation of RNA export from nucleus (GO:0046831)2.46676510
103negative regulation of homotypic cell-cell adhesion (GO:0034111)2.46206949
104adhesion of symbiont to host (GO:0044406)2.45931688
105sarcomere organization (GO:0045214)2.45916334
106cardiac muscle cell proliferation (GO:0060038)2.45236120
107relaxation of cardiac muscle (GO:0055119)2.44763215
108vesicle coating (GO:0006901)2.44421376
109embryonic process involved in female pregnancy (GO:0060136)2.43639657
110negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.43015952
111maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.41520685
112positive regulation of glycogen metabolic process (GO:0070875)2.41019855
113modulation by symbiont of host cellular process (GO:0044068)2.40663416
114regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.39807949
115myofibril assembly (GO:0030239)2.37098422
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.36826146
117collagen fibril organization (GO:0030199)2.35584843
118adhesion of symbiont to host cell (GO:0044650)2.35249145
119virion attachment to host cell (GO:0019062)2.35249145
120NIK/NF-kappaB signaling (GO:0038061)2.34118596
121positive regulation of p38MAPK cascade (GO:1900745)2.33624407
122positive regulation of SMAD protein import into nucleus (GO:0060391)2.32917819
123regulation of early endosome to late endosome transport (GO:2000641)2.32371189
124regulation of histone H3-K27 methylation (GO:0061085)2.32187488
125membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.32021742
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.31594569
127cell-substrate adherens junction assembly (GO:0007045)2.31577811
128focal adhesion assembly (GO:0048041)2.31577811
129thymic T cell selection (GO:0045061)2.30961865
130hypotonic response (GO:0006971)2.30812182
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.29100728
132regulation of extracellular matrix disassembly (GO:0010715)2.29046207
133camera-type eye morphogenesis (GO:0048593)2.28892955
134activation of MAPKKK activity (GO:0000185)2.28424744
135fatty acid transmembrane transport (GO:1902001)2.27213236
136negative regulation of vascular permeability (GO:0043116)2.27065184
137regulation of nuclease activity (GO:0032069)2.26343634
138regulation of SMAD protein import into nucleus (GO:0060390)2.25902330
139negative regulation of protein localization to plasma membrane (GO:1903077)2.25726576
140protein retention in ER lumen (GO:0006621)2.25566994
141barbed-end actin filament capping (GO:0051016)2.25246678
142fibroblast migration (GO:0010761)2.24925268
143positive thymic T cell selection (GO:0045059)2.24719972
144regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.24379646
145potassium ion import (GO:0010107)2.23752852
146positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.23680444
147vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.23331840
148regulation of synapse structural plasticity (GO:0051823)2.23278566
149gastrulation with mouth forming second (GO:0001702)2.22539573
150oxaloacetate metabolic process (GO:0006107)2.21984416
151endoplasmic reticulum unfolded protein response (GO:0030968)2.21718108
152regulation of polysaccharide biosynthetic process (GO:0032885)2.21651918
153hemidesmosome assembly (GO:0031581)2.21206247
154germinal center formation (GO:0002467)2.20970034
155bone trabecula formation (GO:0060346)2.20043587
156positive regulation of extracellular matrix organization (GO:1903055)2.19988445
157endocardial cushion development (GO:0003197)2.19916466
1582-oxoglutarate metabolic process (GO:0006103)2.18790065
159heart morphogenesis (GO:0003007)2.18526320
160regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.18143954
161negative regulation of necroptotic process (GO:0060546)2.15839113
162cellular response to interferon-alpha (GO:0035457)2.15731174
163positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.15416962
164activation of Rac GTPase activity (GO:0032863)2.15085758
165mature B cell differentiation involved in immune response (GO:0002313)2.14927979
166positive regulation of endothelial cell apoptotic process (GO:2000353)2.13097153
167positive regulation of gluconeogenesis (GO:0045722)2.12846302
168cortical actin cytoskeleton organization (GO:0030866)2.12340261
169immunoglobulin mediated immune response (GO:0016064)2.11222195
170regulation of integrin activation (GO:0033623)2.10051487
171regulation of necrotic cell death (GO:0010939)2.09808759
172CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.08477345
173ER-nucleus signaling pathway (GO:0006984)2.08277119
174regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.07086980
175negative regulation of cell killing (GO:0031342)2.06203562
176negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.06203562
177iron ion import (GO:0097286)2.04688760
178negative regulation of viral release from host cell (GO:1902187)2.04621142
179cellular response to unfolded protein (GO:0034620)2.02732147
180regulation of dendritic cell antigen processing and presentation (GO:0002604)2.02458635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.18864992
2CLOCK_20551151_ChIP-Seq_293T_Human4.03109248
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.88087852
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.73912578
5VDR_21846776_ChIP-Seq_THP-1_Human2.73475823
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.62496836
7ZFP281_18757296_ChIP-ChIP_E14_Mouse2.57159748
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.55129985
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.53289437
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52012842
11* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.30844752
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26703244
13STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.20886838
14EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15549957
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09060827
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.97797298
17ZNF263_19887448_ChIP-Seq_K562_Human1.95005769
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.93980898
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.92015788
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91873133
21IRF8_22096565_ChIP-ChIP_GC-B_Human1.85030707
22VDR_24763502_ChIP-Seq_THP-1_Human1.84034036
23* KDM2B_26808549_Chip-Seq_DND41_Human1.83166872
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.80360457
25KDM2B_26808549_Chip-Seq_K562_Human1.79820981
26HIF1A_21447827_ChIP-Seq_MCF-7_Human1.79801937
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.79045650
28MAF_26560356_Chip-Seq_TH1_Human1.78342630
29TBX20_22080862_ChIP-Seq_HEART_Mouse1.77554134
30TBX20_22328084_ChIP-Seq_HEART_Mouse1.77554134
31ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.74336022
32ZFP281_27345836_Chip-Seq_ESCs_Mouse1.72937407
33NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68626934
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68317118
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67253486
36GATA1_19941826_ChIP-Seq_K562_Human1.67090031
37ELK3_25401928_ChIP-Seq_HUVEC_Human1.67069697
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.67006003
39DROSHA_22980978_ChIP-Seq_HELA_Human1.64098290
40MYC_22102868_ChIP-Seq_BL_Human1.64071770
41BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63583863
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61737306
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61669192
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60939995
45* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.58506110
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.58313671
47EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.57331410
48UTX_26944678_Chip-Seq_JUKART_Human1.57193351
49NCOR1_26117541_ChIP-Seq_K562_Human1.56643833
50STAT6_21828071_ChIP-Seq_BEAS2B_Human1.54340544
51* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52951032
52FOXO3_23340844_ChIP-Seq_DLD1_Human1.51929232
53TCF7_22412390_ChIP-Seq_EML_Mouse1.49561343
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49394277
55SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48538975
56FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.47736225
57SCL_19346495_ChIP-Seq_HPC-7_Human1.47534636
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46492449
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.45273162
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.43822027
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43683435
62KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43656213
63LXR_22292898_ChIP-Seq_THP-1_Human1.42074974
64* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41524084
65GATA1_22383799_ChIP-Seq_G1ME_Mouse1.40221150
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.38889470
67MAF_26560356_Chip-Seq_TH2_Human1.38620501
68SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37290404
69ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.37149821
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.36717152
71RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34325153
72KDM2B_26808549_Chip-Seq_JURKAT_Human1.34119767
73RACK7_27058665_Chip-Seq_MCF-7_Human1.32711021
74NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32710654
75ISL1_27105846_Chip-Seq_CPCs_Mouse1.32194559
76PPARA_22158963_ChIP-Seq_LIVER_Mouse1.31263388
77ATF3_27146783_Chip-Seq_COLON_Human1.30319084
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30149767
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29612623
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.29218600
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28753263
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.27380770
83GATA1_22025678_ChIP-Seq_K562_Human1.26262845
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.26121552
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.25543038
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25020127
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24098455
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.23852645
89* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20667336
90* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20639790
91CREB1_26743006_Chip-Seq_LNCaP_Human1.20483252
92WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20121567
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.18086775
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.17953155
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17870942
96PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17688041
97RXR_22158963_ChIP-Seq_LIVER_Mouse1.17326878
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15352360
99SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.15006956
100* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14570186
101HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14323812
102BRD4_25478319_ChIP-Seq_HGPS_Human1.13463967
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12368008
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.11506002
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10389655
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.09296290
107* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08889194
108GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08885387
109RARB_27405468_Chip-Seq_BRAIN_Mouse1.08793562
110UBF1/2_26484160_Chip-Seq_HMECs_Human1.08444056
111FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.08428039
112KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07770001
113PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07513743
114TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.07435100
115SPI1_23127762_ChIP-Seq_K562_Human1.07238185
116ESR1_21235772_ChIP-Seq_MCF-7_Human1.06900525
117E2F7_22180533_ChIP-Seq_HELA_Human1.06260485
118MYB_26560356_Chip-Seq_TH1_Human1.06126390
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05651722
120SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05609567
121* IRF8_27001747_Chip-Seq_BMDM_Mouse1.05382574
122P68_20966046_ChIP-Seq_HELA_Human1.04524491
123TP53_22127205_ChIP-Seq_IMR90_Human1.04459736
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03201818
125SMC4_20622854_ChIP-Seq_HELA_Human1.03047215
126ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03008147
127FOXA2_19822575_ChIP-Seq_HepG2_Human1.02224317
128KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01873165
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.00902243
130GATA2_19941826_ChIP-Seq_K562_Human1.00836821
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00695541
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99103755
133TET1_21451524_ChIP-Seq_MESCs_Mouse0.97695658
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96543730
135E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.96305690
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96158735
137CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95869622
138CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95025216
139FOXM1_23109430_ChIP-Seq_U2OS_Human0.95000864
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94802577
141TP53_23651856_ChIP-Seq_MEFs_Mouse0.93530306
142* MITF_21258399_ChIP-Seq_MELANOMA_Human0.90923528
143NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.90451450
144CJUN_26792858_Chip-Seq_BT549_Human0.89861938
145GATA2_21666600_ChIP-Seq_HMVEC_Human0.89733916
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89488735
147GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89081969
148SMAD_19615063_ChIP-ChIP_OVARY_Human0.88887679
149NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.88556489
150KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88438023
151ERG_21242973_ChIP-ChIP_JURKAT_Human0.87609092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.59572354
2MP0008438_abnormal_cutaneous_collagen4.32187537
3MP0002837_dystrophic_cardiac_calcinosis2.98699467
4MP0004084_abnormal_cardiac_muscle2.87657820
5MP0005451_abnormal_body_composition2.78740129
6MP0005058_abnormal_lysosome_morphology2.72335959
7MP0003279_aneurysm2.52733310
8MP0002877_abnormal_melanocyte_morpholog2.39932293
9MP0006054_spinal_hemorrhage2.31931699
10MP0000751_myopathy2.27551282
11MP0004130_abnormal_muscle_cell2.24462686
12MP0003283_abnormal_digestive_organ2.18749646
13MP0009840_abnormal_foam_cell2.16006302
14MP0003763_abnormal_thymus_physiology2.13316490
15MP0005275_abnormal_skin_tensile2.12032109
16MP0003303_peritoneal_inflammation2.11166715
17MP0004272_abnormal_basement_membrane2.04481817
18MP0003566_abnormal_cell_adhesion2.03444918
19MP0005623_abnormal_meninges_morphology2.01042012
20MP0000013_abnormal_adipose_tissue1.99836263
21MP0004215_abnormal_myocardial_fiber1.96849099
22MP0010234_abnormal_vibrissa_follicle1.92175805
23MP0005666_abnormal_adipose_tissue1.91699748
24MP0008961_abnormal_basal_metabolism1.82916682
25MP0008260_abnormal_autophagy1.78277464
26MP0005464_abnormal_platelet_physiology1.72384082
27MP0004087_abnormal_muscle_fiber1.72346166
28MP0008775_abnormal_heart_ventricle1.71146686
29MP0004185_abnormal_adipocyte_glucose1.69865273
30MP0001958_emphysema1.68329547
31MP0003646_muscle_fatigue1.68044218
32MP0010030_abnormal_orbit_morphology1.65435905
33MP0004036_abnormal_muscle_relaxation1.62732599
34MP0003436_decreased_susceptibility_to1.62586109
35MP0010630_abnormal_cardiac_muscle1.62541467
36MP0010352_gastrointestinal_tract_polyps1.62432107
37MP0003122_maternal_imprinting1.61832548
38MP0005503_abnormal_tendon_morphology1.59821205
39MP0005670_abnormal_white_adipose1.55093822
40MP0005409_darkened_coat_color1.54953428
41MP0003453_abnormal_keratinocyte_physiol1.54480665
42MP0005408_hypopigmentation1.54413025
43MP0005375_adipose_tissue_phenotype1.53152307
44MP0003191_abnormal_cellular_cholesterol1.52838561
45MP0006138_congestive_heart_failure1.49085621
46MP0004858_abnormal_nervous_system1.48859599
47MP0004233_abnormal_muscle_weight1.47580187
48MP0001544_abnormal_cardiovascular_syste1.43777972
49MP0005385_cardiovascular_system_phenoty1.43777972
50MP0002972_abnormal_cardiac_muscle1.43525689
51MP0001835_abnormal_antigen_presentation1.42920266
52MP0003123_paternal_imprinting1.41060848
53MP0000003_abnormal_adipose_tissue1.40505253
54MP0000569_abnormal_digit_pigmentation1.40384256
55MP0000537_abnormal_urethra_morphology1.39336078
56MP0005167_abnormal_blood-brain_barrier1.38497074
57MP0010368_abnormal_lymphatic_system1.38460523
58MP0009278_abnormal_bone_marrow1.37479271
59MP0004947_skin_inflammation1.37268999
60MP0000858_altered_metastatic_potential1.37039235
61MP0000733_abnormal_muscle_development1.34839277
62MP0009780_abnormal_chondrocyte_physiolo1.34134186
63MP0000685_abnormal_immune_system1.31354104
64MP0005620_abnormal_muscle_contractility1.29970877
65MP0002089_abnormal_postnatal_growth/wei1.29757011
66MP0005075_abnormal_melanosome_morpholog1.29281977
67MP0002166_altered_tumor_susceptibility1.26535184
68MP0002909_abnormal_adrenal_gland1.26089421
69MP0003656_abnormal_erythrocyte_physiolo1.24503699
70MP0003115_abnormal_respiratory_system1.23675749
71MP0002796_impaired_skin_barrier1.22463072
72MP0005023_abnormal_wound_healing1.20559335
73MP0005076_abnormal_cell_differentiation1.20263367
74MP0003300_gastrointestinal_ulcer1.19265833
75MP0003172_abnormal_lysosome_physiology1.19104056
76MP0004808_abnormal_hematopoietic_stem1.16484520
77MP0002269_muscular_atrophy1.16373511
78MP0002128_abnormal_blood_circulation1.13853716
79MP0005330_cardiomyopathy1.13068384
80MP0005387_immune_system_phenotype1.09431967
81MP0001790_abnormal_immune_system1.09431967
82MP0005000_abnormal_immune_tolerance1.09272544
83MP0002060_abnormal_skin_morphology1.08503661
84MP0010155_abnormal_intestine_physiology1.07748533
85MP0001849_ear_inflammation1.06784950
86MP0003091_abnormal_cell_migration1.05758212
87MP0001915_intracranial_hemorrhage1.05459149
88MP0005025_abnormal_response_to1.05350391
89MP0001800_abnormal_humoral_immune1.04716587
90MP0005397_hematopoietic_system_phenotyp1.04545431
91MP0001545_abnormal_hematopoietic_system1.04545431
92MP0003567_abnormal_fetal_cardiomyocyte1.03679868
93MP0000749_muscle_degeneration1.03638674
94MP0004510_myositis1.02960714
95MP0002396_abnormal_hematopoietic_system1.02239808
96MP0002398_abnormal_bone_marrow1.02162396
97MP0005187_abnormal_penis_morphology1.01807416
98MP0000266_abnormal_heart_morphology1.01690910
99MP0000371_diluted_coat_color1.01532596
100MP0001661_extended_life_span1.00921618
101MP0000015_abnormal_ear_pigmentation1.00646863
102MP0002971_abnormal_brown_adipose1.00499151
103MP0001873_stomach_inflammation0.99988993
104MP0002419_abnormal_innate_immunity0.99477246
105MP0002090_abnormal_vision0.99155741
106MP0009333_abnormal_splenocyte_physiolog0.98483827
107MP0000534_abnormal_ureter_morphology0.98204337
108MP0003045_fibrosis0.97770874
109MP0000759_abnormal_skeletal_muscle0.97617174
110MP0002452_abnormal_antigen_presenting0.97284873
111MP0000465_gastrointestinal_hemorrhage0.96723536
112MP0004264_abnormal_extraembryonic_tissu0.96067193
113MP0000703_abnormal_thymus_morphology0.94564985
114MP0009384_cardiac_valve_regurgitation0.93357616
115MP0003221_abnormal_cardiomyocyte_apopto0.92938847
116MP0000428_abnormal_craniofacial_morphol0.92842245
117MP0002998_abnormal_bone_remodeling0.92695018
118MP0001819_abnormal_immune_cell0.92598753
119MP0002925_abnormal_cardiovascular_devel0.92470860
120MP0001614_abnormal_blood_vessel0.92468146
121MP0008004_abnormal_stomach_pH0.92221590
122MP0002420_abnormal_adaptive_immunity0.92023405
123MP0004484_altered_response_of0.91934641
124MP0001348_abnormal_lacrimal_gland0.91784840
125MP0004859_abnormal_synaptic_plasticity0.91697131
126MP0001299_abnormal_eye_distance/0.90585005
127MP0000750_abnormal_muscle_regeneration0.90104868
128MP0002722_abnormal_immune_system0.89966712
129MP0003121_genomic_imprinting0.89306753
130MP0005501_abnormal_skin_physiology0.89297287
131MP0001533_abnormal_skeleton_physiology0.88261286
132MP0005621_abnormal_cell_physiology0.87424487
133MP0002009_preneoplasia0.87153595
134MP0000343_altered_response_to0.86826425
135MP0002295_abnormal_pulmonary_circulatio0.86486244
136MP0001879_abnormal_lymphatic_vessel0.85264524
137MP0002106_abnormal_muscle_physiology0.85221715
138MP0002282_abnormal_trachea_morphology0.84335713
139MP0002896_abnormal_bone_mineralization0.84127093
140MP0010307_abnormal_tumor_latency0.83939605
141MP0003828_pulmonary_edema0.83743097
142MP0000767_abnormal_smooth_muscle0.83342093
143MP0002723_abnormal_immune_serum0.83119594
144MP0003942_abnormal_urinary_system0.82110713
145MP0000716_abnormal_immune_system0.81849768
146MP0002234_abnormal_pharynx_morphology0.81700774
147MP0002429_abnormal_blood_cell0.81597680
148MP0003724_increased_susceptibility_to0.79011729
149MP0002006_tumorigenesis0.78936883
150MP0005257_abnormal_intraocular_pressure0.78902840
151MP0002086_abnormal_extraembryonic_tissu0.78367932
152MP0003385_abnormal_body_wall0.77209271
153MP0000678_abnormal_parathyroid_gland0.76395852
154MP0004085_abnormal_heartbeat0.73974078
155MP0001270_distended_abdomen0.73653231
156MP0004197_abnormal_fetal_growth/weight/0.72343609
157MP0003935_abnormal_craniofacial_develop0.72065846
158MP0005508_abnormal_skeleton_morphology0.71985920
159MP0002932_abnormal_joint_morphology0.71600024
160MP0002249_abnormal_larynx_morphology0.71422933
161MP0000747_muscle_weakness0.69676942

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.23364769
2Subacute progressive viral hepatitis (HP:0006572)4.02515238
3Cerebral aneurysm (HP:0004944)3.96109313
4Hyperacusis (HP:0010780)3.40724145
5Shallow orbits (HP:0000586)3.38831035
6Ankle contracture (HP:0006466)3.37613871
7Broad metatarsal (HP:0001783)3.26077357
8B lymphocytopenia (HP:0010976)3.19541734
9Enlarged penis (HP:0000040)3.14918037
10Gastrointestinal stroma tumor (HP:0100723)2.98378323
11Bladder diverticulum (HP:0000015)2.92123402
12Bowel diverticulosis (HP:0005222)2.92007506
13Abnormality of B cell number (HP:0010975)2.86361313
14Lymphangioma (HP:0100764)2.81352409
15Aortic dissection (HP:0002647)2.81095970
16Aortic aneurysm (HP:0004942)2.68327749
17Increased IgE level (HP:0003212)2.67398837
18Aneurysm (HP:0002617)2.66873956
19Increased connective tissue (HP:0009025)2.66670597
20Vertebral compression fractures (HP:0002953)2.63194175
21Abnormality of the peritoneum (HP:0002585)2.62399794
22IgM deficiency (HP:0002850)2.54461987
23Premature rupture of membranes (HP:0001788)2.51014225
24Hand muscle atrophy (HP:0009130)2.49966135
25Emphysema (HP:0002097)2.49792285
26Eczematoid dermatitis (HP:0000976)2.49612393
27Long toe (HP:0010511)2.42793161
28Distal upper limb amyotrophy (HP:0007149)2.42274015
29Upper limb amyotrophy (HP:0009129)2.42274015
30Cellulitis (HP:0100658)2.41496084
31Colitis (HP:0002583)2.40657523
32Striae distensae (HP:0001065)2.39248311
33Centrally nucleated skeletal muscle fibers (HP:0003687)2.35742868
34Elfin facies (HP:0004428)2.35468791
35Dilatation of the ascending aorta (HP:0005111)2.30983859
36Polycythemia (HP:0001901)2.30382316
37Vertebral arch anomaly (HP:0008438)2.29171427
38Thin bony cortex (HP:0002753)2.28794165
39Mitral valve prolapse (HP:0001634)2.28042376
40Viral hepatitis (HP:0006562)2.25647495
41Renovascular hypertension (HP:0100817)2.25273534
42Renal duplication (HP:0000075)2.22688609
43Fragile skin (HP:0001030)2.21130542
44Cervical subluxation (HP:0003308)2.19052512
45Flat acetabular roof (HP:0003180)2.16764978
46Insomnia (HP:0100785)2.16228927
47Pointed chin (HP:0000307)2.15681230
48Arterial tortuosity (HP:0005116)2.15505851
49Gastrointestinal inflammation (HP:0004386)2.15284293
50Cupped ribs (HP:0000887)2.14403669
51Elbow flexion contracture (HP:0002987)2.14325305
52Distal lower limb amyotrophy (HP:0008944)2.13885831
53Abnormality of skeletal muscle fiber size (HP:0012084)2.12764648
54Ragged-red muscle fibers (HP:0003200)2.12027450
55Abnormality of the fingertips (HP:0001211)2.11645478
56Myoglobinuria (HP:0002913)2.08588746
57Sudden death (HP:0001699)2.06906602
58Disproportionate tall stature (HP:0001519)2.06763149
59Lipoatrophy (HP:0100578)2.05097642
60Micronodular cirrhosis (HP:0001413)2.04083945
61Broad palm (HP:0001169)2.03526251
62Abnormality of the 4th metacarpal (HP:0010012)2.03167453
63Scapular winging (HP:0003691)2.02047551
64Vascular tortuosity (HP:0004948)2.01156979
65Broad face (HP:0000283)2.00202986
66Hemorrhage of the eye (HP:0011885)1.99085304
67Inflammation of the large intestine (HP:0002037)1.98988274
68Short 4th metacarpal (HP:0010044)1.97874221
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97874221
70Difficulty running (HP:0009046)1.97851090
71Distal lower limb muscle weakness (HP:0009053)1.97844486
72Exercise-induced muscle cramps (HP:0003710)1.97448467
73Ependymoma (HP:0002888)1.97234259
74Mediastinal lymphadenopathy (HP:0100721)1.96668831
75Leiomyosarcoma (HP:0100243)1.95764417
76Uterine leiomyosarcoma (HP:0002891)1.95764417
77Hematochezia (HP:0002573)1.94703299
78Type 1 muscle fiber predominance (HP:0003803)1.94165779
79Peritonitis (HP:0002586)1.93944901
80Spondylolisthesis (HP:0003302)1.93088489
81Ketoacidosis (HP:0001993)1.92520263
82Ankyloglossia (HP:0010296)1.92367293
83Wormian bones (HP:0002645)1.92213883
84Wrist flexion contracture (HP:0001239)1.91233288
85Osteolytic defects of the phalanges of the hand (HP:0009771)1.90930438
86Osteolytic defects of the hand bones (HP:0009699)1.90930438
87IgA deficiency (HP:0002720)1.90778318
88Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.86094208
89Abnormality of the thoracic spine (HP:0100711)1.85554441
90Neoplasm of the heart (HP:0100544)1.85182303
91Joint laxity (HP:0001388)1.85178267
92Malignant gastrointestinal tract tumors (HP:0006749)1.85016347
93Gastrointestinal carcinoma (HP:0002672)1.85016347
94Recurrent viral infections (HP:0004429)1.84634227
95Flat cornea (HP:0007720)1.83867514
96Syringomyelia (HP:0003396)1.83030536
97Spinal cord lesions (HP:0100561)1.83030536
98Astrocytoma (HP:0009592)1.82883930
99Abnormality of the astrocytes (HP:0100707)1.82883930
100Persistence of primary teeth (HP:0006335)1.81487713
101Hypercortisolism (HP:0001578)1.80364823
102Prolonged bleeding time (HP:0003010)1.79971288
103Abnormality of oral frenula (HP:0000190)1.79707853
104Back pain (HP:0003418)1.78763776
105Asymmetric septal hypertrophy (HP:0001670)1.78474201
106Bundle branch block (HP:0011710)1.78213799
107Achilles tendon contracture (HP:0001771)1.77268239
108Hemiplegia (HP:0002301)1.77131961
109Mitral regurgitation (HP:0001653)1.76785106
110Atrophic scars (HP:0001075)1.76571435
111Diminished motivation (HP:0000745)1.75127588
112Spinal rigidity (HP:0003306)1.74892228
113Mesangial abnormality (HP:0001966)1.74628119
114Exostoses (HP:0100777)1.74373155
115Impaired pain sensation (HP:0007328)1.74335046
116Abnormality of pain sensation (HP:0010832)1.74335046
117Asymmetry of the thorax (HP:0001555)1.73953954
118Genu recurvatum (HP:0002816)1.73626310
119Spontaneous hematomas (HP:0007420)1.73455623
120Blue sclerae (HP:0000592)1.73328235
121Right ventricular cardiomyopathy (HP:0011663)1.73244751
122Apathy (HP:0000741)1.72711742
123Restrictive lung disease (HP:0002091)1.71880601
124Abnormality of the acetabulum (HP:0003170)1.71836317
125Central scotoma (HP:0000603)1.70950211
126Deviation of the hallux (HP:0010051)1.70795681
127Ventricular tachycardia (HP:0004756)1.70100871
128Deep palmar crease (HP:0006191)1.69685598
129Soft skin (HP:0000977)1.69057252
130Polygenic inheritance (HP:0010982)1.68264867
131Biconcave vertebral bodies (HP:0004586)1.68174710
132Long palpebral fissure (HP:0000637)1.67540234
133Dysostosis multiplex (HP:0000943)1.66110693
134Reticulocytosis (HP:0001923)1.65066494
135Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.64959394
136Hemangiomatosis (HP:0007461)1.64392770
137Ulnar bowing (HP:0003031)1.64297720
138Atrial fibrillation (HP:0005110)1.64077284
139Fibroma (HP:0010614)1.63995789
140Fatigue (HP:0012378)1.63992671
141Abnormality of dentin (HP:0010299)1.63968423
142Visceral angiomatosis (HP:0100761)1.63747136
143Bone pain (HP:0002653)1.63343604
144Camptodactyly of toe (HP:0001836)1.62979623
145Turricephaly (HP:0000262)1.62882519
146Abnormality of the Achilles tendon (HP:0005109)1.62099069
147Obstructive sleep apnea (HP:0002870)1.61680896
148Interstitial pulmonary disease (HP:0006530)1.61328480
149Recurrent bronchitis (HP:0002837)1.61285141
150Increased variability in muscle fiber diameter (HP:0003557)1.61111014
151Femoral bowing (HP:0002980)1.60932593
152Slender long bone (HP:0003100)1.60915746
153Cortical dysplasia (HP:0002539)1.59628961
154Gingivitis (HP:0000230)1.59343090
155Hamartoma of the eye (HP:0010568)1.59257277
156Fibrous tissue neoplasm (HP:0012316)1.59209101
157Abnormality of macrophages (HP:0004311)1.59033349
158J-shaped sella turcica (HP:0002680)1.59032595
159Prolonged QT interval (HP:0001657)1.58968470
160Transitional cell carcinoma of the bladder (HP:0006740)1.58748288
161Macroorchidism (HP:0000053)1.58238160
162Mildly elevated creatine phosphokinase (HP:0008180)1.58156523
163Hallux valgus (HP:0001822)1.57957427
164Abnormality of complement system (HP:0005339)1.57893695
165Thoracic kyphosis (HP:0002942)1.56162215
166Segmental peripheral demyelination/remyelination (HP:0003481)1.55878756
167Abnormality of skull ossification (HP:0002703)1.55165697
168Abnormality of T cell physiology (HP:0011840)1.53664379

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB35.37867712
2PKN24.33164443
3PRPF4B3.00504779
4EEF2K2.92062763
5TTN2.76940188
6RIPK12.40020619
7PDGFRA2.27626193
8LATS12.22630773
9SCYL22.12627590
10LMTK22.07562426
11RIPK41.99917147
12NEK11.98077353
13ICK1.96331631
14PRKD31.91615967
15LATS21.90287215
16KSR21.87651244
17SMG11.87189042
18KSR11.85695351
19NEK91.84850656
20PTK61.82290115
21MAP3K91.68395680
22IRAK31.67896942
23MAP3K61.65926468
24PAK61.60552974
25MAP4K11.59117294
26ERN11.57161535
27MAPK111.54780445
28RET1.46882959
29MAP3K101.37354671
30NME21.34686236
31JAK31.26392943
32CAMK1D1.25881711
33NLK1.25577587
34MAP3K31.23862388
35MAP3K11.23398063
36CSK1.22996234
37TBK11.21516877
38TGFBR11.21253193
39PAK31.20859087
40PAK41.18410895
41DDR21.15923907
42TAOK11.15796916
43ZAP701.13436359
44ARAF1.09844325
45MAPKAPK31.09027121
46BMX1.07233938
47FLT31.06782961
48MAP3K131.05861357
49PHKG11.05220707
50PHKG21.05220707
51CDK41.03941817
52PDK41.03710481
53PDK31.03710481
54TIE10.99289762
55EPHB20.98367676
56SIK10.95150879
57MARK20.91917605
58MAP3K140.91755215
59CAMKK10.91096682
60STK380.88205575
61TGFBR20.86364357
62DAPK20.84735655
63BTK0.83635553
64TYRO30.82482336
65TAOK20.81831000
66LRRK20.81300634
67DMPK0.79757855
68BLK0.77659601
69PRKCH0.77110722
70CAMK1G0.75214332
71MAP2K10.73609829
72ILK0.73251942
73MTOR0.73189665
74MINK10.72430835
75IKBKE0.71950829
76SGK30.71591830
77PTK20.71502268
78FER0.71171728
79PRKD10.67875605
80HCK0.67488037
81NTRK10.67179965
82INSRR0.66440385
83SYK0.65989158
84PRKCI0.65619242
85RAF10.65130315
86FGFR10.64370501
87MAP2K30.63888926
88MAPK120.62955262
89GRK60.61523958
90MAP3K40.60903488
91RPS6KA20.60879016
92IRAK40.60795706
93BCKDK0.60094523
94PRKAA10.58354858
95CDK60.58335019
96MST1R0.58223290
97ERBB30.58095672
98PDGFRB0.57673629
99EPHA20.57049779
100PAK20.56922711
101MAP3K110.56891156
102RPS6KB20.55369685
103MYLK0.55328971
104HIPK20.55064804
105BRAF0.55052048
106PRKD20.54263194
107MAP2K40.53753152
108TRPM70.52728883
109PTK2B0.52257245
110KIT0.51744815
111CLK10.50766609
112ROCK10.49413504
113FGFR40.49382445
114MET0.48250036
115CDK120.48184984
116TYK20.47947182
117MAP3K70.47365692
118CDC42BPA0.47109415
119MOS0.46771947
120RPS6KC10.45877294
121RPS6KL10.45877294
122NEK20.44456747
123CSF1R0.44419294
124MELK0.44074217
125MAP2K20.43783467
126RPS6KA40.43221108
127MARK30.40713061
128JAK10.40561685
129FGFR30.40187037
130MAP3K50.39499376
131MAP3K20.38138840
132ITK0.38098928
133AKT20.37543219
134EPHA30.36805115
135TTK0.35882487
136EPHB10.35168273
137MAP3K80.35134867
138JAK20.34684377
139PDPK10.32910128
140PRKAA20.31563844
141PDK10.31144807
142PDK20.29701756

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.38253089
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.38408719
3Other glycan degradation_Homo sapiens_hsa005112.33127268
4B cell receptor signaling pathway_Homo sapiens_hsa046622.20967635
5Acute myeloid leukemia_Homo sapiens_hsa052212.20724706
6Dilated cardiomyopathy_Homo sapiens_hsa054141.74188391
7Primary immunodeficiency_Homo sapiens_hsa053401.70604749
8Nitrogen metabolism_Homo sapiens_hsa009101.60508998
9Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.50732114
10Osteoclast differentiation_Homo sapiens_hsa043801.50381945
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.50182082
12Insulin resistance_Homo sapiens_hsa049311.44874065
13Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.44434300
14T cell receptor signaling pathway_Homo sapiens_hsa046601.43959442
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.42498460
16Prion diseases_Homo sapiens_hsa050201.41646882
17Fatty acid degradation_Homo sapiens_hsa000711.40591563
18Bladder cancer_Homo sapiens_hsa052191.40030541
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.39891246
20Focal adhesion_Homo sapiens_hsa045101.39010110
21Thyroid cancer_Homo sapiens_hsa052161.37880143
22Propanoate metabolism_Homo sapiens_hsa006401.36016485
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.35503508
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.34030089
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31975303
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31187712
27Hepatitis B_Homo sapiens_hsa051611.30577892
28Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.30454441
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.30097007
30Fatty acid metabolism_Homo sapiens_hsa012121.25585994
31Endometrial cancer_Homo sapiens_hsa052131.22839315
32Influenza A_Homo sapiens_hsa051641.22564699
33Proteoglycans in cancer_Homo sapiens_hsa052051.22552381
34Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21228619
35Type II diabetes mellitus_Homo sapiens_hsa049301.20080378
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.19702001
37Chronic myeloid leukemia_Homo sapiens_hsa052201.18225155
38Lysine degradation_Homo sapiens_hsa003101.18025015
39Carbon metabolism_Homo sapiens_hsa012001.17045650
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17033568
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15402235
42Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.15155094
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14530165
44mTOR signaling pathway_Homo sapiens_hsa041501.13864671
45Prostate cancer_Homo sapiens_hsa052151.13398614
46Pancreatic cancer_Homo sapiens_hsa052121.12752460
47PPAR signaling pathway_Homo sapiens_hsa033201.12490135
48Glioma_Homo sapiens_hsa052141.09650741
49Hepatitis C_Homo sapiens_hsa051601.08475843
50Insulin signaling pathway_Homo sapiens_hsa049101.07264522
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05638880
52Colorectal cancer_Homo sapiens_hsa052101.04311219
53VEGF signaling pathway_Homo sapiens_hsa043701.04096983
54HTLV-I infection_Homo sapiens_hsa051661.04059452
55ECM-receptor interaction_Homo sapiens_hsa045121.03445844
56Glucagon signaling pathway_Homo sapiens_hsa049221.01265477
57Glycosaminoglycan degradation_Homo sapiens_hsa005311.01113178
58Choline metabolism in cancer_Homo sapiens_hsa052311.01046654
59Estrogen signaling pathway_Homo sapiens_hsa049151.00833329
60Small cell lung cancer_Homo sapiens_hsa052221.00690177
61ErbB signaling pathway_Homo sapiens_hsa040121.00630640
62Adherens junction_Homo sapiens_hsa045201.00377199
63Staphylococcus aureus infection_Homo sapiens_hsa051501.00326498
64Apoptosis_Homo sapiens_hsa042100.99961608
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98740666
66Amoebiasis_Homo sapiens_hsa051460.97945059
67GnRH signaling pathway_Homo sapiens_hsa049120.97095451
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.96613767
69Measles_Homo sapiens_hsa051620.95668184
70Tuberculosis_Homo sapiens_hsa051520.95020512
71HIF-1 signaling pathway_Homo sapiens_hsa040660.94927094
72Galactose metabolism_Homo sapiens_hsa000520.94065281
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93691133
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.93572483
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.92833326
76Non-small cell lung cancer_Homo sapiens_hsa052230.92797168
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92117570
78Hippo signaling pathway_Homo sapiens_hsa043900.92042313
79Platelet activation_Homo sapiens_hsa046110.91754827
80Fatty acid biosynthesis_Homo sapiens_hsa000610.91189317
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.91122141
82AMPK signaling pathway_Homo sapiens_hsa041520.88987339
83Herpes simplex infection_Homo sapiens_hsa051680.88509978
84Viral carcinogenesis_Homo sapiens_hsa052030.88430587
85Oxytocin signaling pathway_Homo sapiens_hsa049210.88005806
86Gap junction_Homo sapiens_hsa045400.87693073
87Insulin secretion_Homo sapiens_hsa049110.87317065
88Biosynthesis of amino acids_Homo sapiens_hsa012300.87112427
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87009113
90Renin secretion_Homo sapiens_hsa049240.85539302
91Prolactin signaling pathway_Homo sapiens_hsa049170.85408051
92Malaria_Homo sapiens_hsa051440.83836221
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82818525
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81617874
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.81292028
96Toxoplasmosis_Homo sapiens_hsa051450.81023780
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81020676
98Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79284093
99Circadian entrainment_Homo sapiens_hsa047130.78995488
100Gastric acid secretion_Homo sapiens_hsa049710.77949042
101Cholinergic synapse_Homo sapiens_hsa047250.77928420
102Lysosome_Homo sapiens_hsa041420.77891309
103Inositol phosphate metabolism_Homo sapiens_hsa005620.76339204
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.76146289
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75936663
106Olfactory transduction_Homo sapiens_hsa047400.75800610
107Pyruvate metabolism_Homo sapiens_hsa006200.75305265
108FoxO signaling pathway_Homo sapiens_hsa040680.75300044
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75134565
110Shigellosis_Homo sapiens_hsa051310.73594585
111Viral myocarditis_Homo sapiens_hsa054160.73556947
112Rap1 signaling pathway_Homo sapiens_hsa040150.73453820
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72656737
114Protein digestion and absorption_Homo sapiens_hsa049740.70407705
115Notch signaling pathway_Homo sapiens_hsa043300.70094175
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.69462618
117Renal cell carcinoma_Homo sapiens_hsa052110.69169738
118Thyroid hormone synthesis_Homo sapiens_hsa049180.68967736
119Allograft rejection_Homo sapiens_hsa053300.68787336
120Synaptic vesicle cycle_Homo sapiens_hsa047210.67386552
121Chemokine signaling pathway_Homo sapiens_hsa040620.67382276
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67076096
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66552785
124Autoimmune thyroid disease_Homo sapiens_hsa053200.66118025
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.66102755
126cAMP signaling pathway_Homo sapiens_hsa040240.65711277
127Melanogenesis_Homo sapiens_hsa049160.64524080
128TGF-beta signaling pathway_Homo sapiens_hsa043500.63397289
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62992321
130Oocyte meiosis_Homo sapiens_hsa041140.62975826
131Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62645956
132Hematopoietic cell lineage_Homo sapiens_hsa046400.62148702
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.62133363
134Fructose and mannose metabolism_Homo sapiens_hsa000510.61829327
135Pentose phosphate pathway_Homo sapiens_hsa000300.61404040
136Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59214997
137Arginine biosynthesis_Homo sapiens_hsa002200.59165128
138Pertussis_Homo sapiens_hsa051330.58849957
139Endocytosis_Homo sapiens_hsa041440.58378638
140Dopaminergic synapse_Homo sapiens_hsa047280.58146325
141Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58080276
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57378561
143MicroRNAs in cancer_Homo sapiens_hsa052060.56963896
144Melanoma_Homo sapiens_hsa052180.56587522
145Circadian rhythm_Homo sapiens_hsa047100.56007280
146Cocaine addiction_Homo sapiens_hsa050300.55150991
147Salivary secretion_Homo sapiens_hsa049700.54571824
148Leishmaniasis_Homo sapiens_hsa051400.54434076
149TNF signaling pathway_Homo sapiens_hsa046680.53960656
150Pathways in cancer_Homo sapiens_hsa052000.51457857

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