FBXO21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)4.70984813
2presynaptic membrane assembly (GO:0097105)4.18451209
3L-phenylalanine catabolic process (GO:0006559)4.08745845
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.08745845
5regulation of short-term neuronal synaptic plasticity (GO:0048172)3.94159398
6presynaptic membrane organization (GO:0097090)3.89626253
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.88766165
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.80386166
9L-phenylalanine metabolic process (GO:0006558)3.80386166
10synaptic vesicle maturation (GO:0016188)3.75973070
11nucleobase catabolic process (GO:0046113)3.75727845
12alpha-linolenic acid metabolic process (GO:0036109)3.72482532
13layer formation in cerebral cortex (GO:0021819)3.70127219
14postsynaptic membrane organization (GO:0001941)3.68636977
15locomotory exploration behavior (GO:0035641)3.54266184
16response to pheromone (GO:0019236)3.50900002
17regulation of synaptic vesicle exocytosis (GO:2000300)3.43859074
18activation of protein kinase A activity (GO:0034199)3.22454461
19aromatic amino acid family catabolic process (GO:0009074)3.14809581
20positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.11603333
21macroautophagy (GO:0016236)3.09329686
22synaptic vesicle exocytosis (GO:0016079)3.05954373
23cellular ketone body metabolic process (GO:0046950)3.02929274
24glutamate secretion (GO:0014047)3.02905626
25glyoxylate metabolic process (GO:0046487)3.02540226
26gamma-aminobutyric acid transport (GO:0015812)3.02367024
27dendritic spine morphogenesis (GO:0060997)2.99021548
28regulation of synaptic vesicle transport (GO:1902803)2.96788750
29regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94925121
30neurotransmitter secretion (GO:0007269)2.94829884
31bile acid biosynthetic process (GO:0006699)2.93578028
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.93488934
33regulation of synapse structural plasticity (GO:0051823)2.90342003
34neuron recognition (GO:0008038)2.89876428
35retinal ganglion cell axon guidance (GO:0031290)2.89396427
36cell migration in hindbrain (GO:0021535)2.89365739
37synaptic vesicle docking involved in exocytosis (GO:0016081)2.88848006
38glutamate metabolic process (GO:0006536)2.88663796
39positive regulation of fatty acid beta-oxidation (GO:0032000)2.86149593
40vocalization behavior (GO:0071625)2.85361646
41regulation of neuronal synaptic plasticity (GO:0048168)2.85293259
42cerebellar Purkinje cell layer development (GO:0021680)2.84094888
43lysine catabolic process (GO:0006554)2.81673826
44lysine metabolic process (GO:0006553)2.81673826
45cell communication by electrical coupling (GO:0010644)2.81186642
46negative regulation of fibrinolysis (GO:0051918)2.80375198
47regulation of glutamate receptor signaling pathway (GO:1900449)2.79933568
48sulfur amino acid catabolic process (GO:0000098)2.79523549
49limb bud formation (GO:0060174)2.78520603
50axonal fasciculation (GO:0007413)2.76893771
51response to dietary excess (GO:0002021)2.75845683
52nonmotile primary cilium assembly (GO:0035058)2.74228744
53urea metabolic process (GO:0019627)2.71791994
54urea cycle (GO:0000050)2.71791994
55synapse assembly (GO:0007416)2.71008621
56positive regulation of synapse maturation (GO:0090129)2.70938053
57exploration behavior (GO:0035640)2.70732660
58complement activation, alternative pathway (GO:0006957)2.69122023
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.68749345
60regulation of fatty acid beta-oxidation (GO:0031998)2.67437135
61dendrite morphogenesis (GO:0048813)2.66962218
62protein localization to synapse (GO:0035418)2.63390491
63auditory behavior (GO:0031223)2.63001051
64dicarboxylic acid biosynthetic process (GO:0043650)2.62963953
65ketone body metabolic process (GO:1902224)2.62839566
66kynurenine metabolic process (GO:0070189)2.62214517
67neurotransmitter-gated ion channel clustering (GO:0072578)2.59867531
68calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59365954
69regulation of long-term neuronal synaptic plasticity (GO:0048169)2.57771081
70high-density lipoprotein particle remodeling (GO:0034375)2.57238264
71central nervous system projection neuron axonogenesis (GO:0021952)2.56627330
72regulation of fibrinolysis (GO:0051917)2.56503691
73neuron cell-cell adhesion (GO:0007158)2.56466385
74proline transport (GO:0015824)2.55597499
75tyrosine metabolic process (GO:0006570)2.55320847
76neutral lipid catabolic process (GO:0046461)2.55156438
77acylglycerol catabolic process (GO:0046464)2.55156438
78bile acid metabolic process (GO:0008206)2.55148129
79alanine transport (GO:0032328)2.54172853
80establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.53519716
81mitochondrion transport along microtubule (GO:0047497)2.53519716
82dicarboxylic acid catabolic process (GO:0043649)2.53105463
83reverse cholesterol transport (GO:0043691)2.51204757
84glycine transport (GO:0015816)2.48364375
85innervation (GO:0060384)2.48207424
86coenzyme catabolic process (GO:0009109)2.48095300
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.45707524
88neuronal action potential propagation (GO:0019227)2.45639589
89alpha-amino acid catabolic process (GO:1901606)2.45492697
90nitrogen cycle metabolic process (GO:0071941)2.43441482
91regulation of dendritic spine morphogenesis (GO:0061001)2.43371418
92acylglycerol homeostasis (GO:0055090)2.42491030
93triglyceride homeostasis (GO:0070328)2.42491030
94coenzyme A metabolic process (GO:0015936)2.41702435
95regulation of protein activation cascade (GO:2000257)2.41682360
96establishment of mitochondrion localization (GO:0051654)2.41163898
97serine family amino acid catabolic process (GO:0009071)2.41159745
98neuromuscular process controlling posture (GO:0050884)2.40569143
99cysteine metabolic process (GO:0006534)2.40487689
100regulation of cholesterol homeostasis (GO:2000188)2.40366752
101hippocampus development (GO:0021766)2.40189898
102neuromuscular process controlling balance (GO:0050885)2.40132767
103negative regulation of cytosolic calcium ion concentration (GO:0051481)2.39800065
104aspartate family amino acid catabolic process (GO:0009068)2.37974588
105transmission of nerve impulse (GO:0019226)2.37733259
106positive regulation of synapse assembly (GO:0051965)2.37297694
107positive regulation of fatty acid oxidation (GO:0046321)2.37268039
108cellular response to glucagon stimulus (GO:0071377)2.36919800
109G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.36838014
110negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36823717
111cellular amino acid catabolic process (GO:0009063)2.36642794
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.36291226
113synaptic vesicle endocytosis (GO:0048488)2.36048600
114acetyl-CoA metabolic process (GO:0006084)2.35750758
115C4-dicarboxylate transport (GO:0015740)2.35512376
116mechanosensory behavior (GO:0007638)2.34061811
117cellular modified amino acid catabolic process (GO:0042219)2.33436999
118peptidyl-glutamic acid carboxylation (GO:0017187)2.33269699
119protein carboxylation (GO:0018214)2.33269699
120olfactory bulb development (GO:0021772)2.33016238
121ionotropic glutamate receptor signaling pathway (GO:0035235)2.32234191
122membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.31852857
123glutamate receptor signaling pathway (GO:0007215)2.30114197
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.27396657
125synapse organization (GO:0050808)2.26308140
126positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.24112954
127ephrin receptor signaling pathway (GO:0048013)2.24090301
128apical protein localization (GO:0045176)2.23745977
129intraciliary transport (GO:0042073)2.23365908
130establishment of nucleus localization (GO:0040023)2.23148509
131paraxial mesoderm development (GO:0048339)2.22856269
132neuronal stem cell maintenance (GO:0097150)2.22029711
133appendage development (GO:0048736)2.21193188
134limb development (GO:0060173)2.21193188
135regulation of synapse assembly (GO:0051963)2.17817148
136central nervous system neuron axonogenesis (GO:0021955)2.17797854
137cochlea development (GO:0090102)2.16549688
138positive regulation of mitochondrial fission (GO:0090141)2.15845953
139neuromuscular synaptic transmission (GO:0007274)2.15643132
140behavioral response to nicotine (GO:0035095)2.15168353
141spinal cord development (GO:0021510)2.14728280
142response to auditory stimulus (GO:0010996)2.14647580
143startle response (GO:0001964)2.13196428
144forebrain neuron differentiation (GO:0021879)2.13049943
145negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.11430690
146regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.07529896
147synaptic transmission, glutamatergic (GO:0035249)2.06317306
148regulation of development, heterochronic (GO:0040034)2.05848525
149negative regulation of oligodendrocyte differentiation (GO:0048715)2.05737589
150histone H2A acetylation (GO:0043968)2.05360433
151dorsal/ventral axis specification (GO:0009950)2.05006237
152DNA damage response, detection of DNA damage (GO:0042769)2.04123505
153dendritic spine organization (GO:0097061)2.03804880
154negative regulation of axon guidance (GO:1902668)2.03257735
155cerebral cortex radially oriented cell migration (GO:0021799)2.03085255
156axonogenesis (GO:0007409)2.02313723
157righting reflex (GO:0060013)1.99261179
158behavioral fear response (GO:0001662)1.98429549
159behavioral defense response (GO:0002209)1.98429549
160DNA double-strand break processing (GO:0000729)1.98018465
161homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)1.97982888
162glycosphingolipid biosynthetic process (GO:0006688)1.96754127
163neuron migration (GO:0001764)1.96656640
164peptidyl-cysteine modification (GO:0018198)1.95638693
165asymmetric protein localization (GO:0008105)1.92209762
166cytoskeleton-dependent intracellular transport (GO:0030705)1.90931707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.27883331
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.78119510
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.29157236
4* RXR_22158963_ChIP-Seq_LIVER_Mouse2.79230845
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.54162365
6* RARB_27405468_Chip-Seq_BRAIN_Mouse2.36038391
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.33051864
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.32779951
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.32103716
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.30322478
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29284398
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29149531
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28802630
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28802630
15* IGF1R_20145208_ChIP-Seq_DFB_Human2.28410920
16REST_21632747_ChIP-Seq_MESCs_Mouse2.26543721
17* LXR_22158963_ChIP-Seq_LIVER_Mouse2.22610945
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.19029201
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18886374
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.17569647
21FUS_26573619_Chip-Seq_HEK293_Human2.17474734
22* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.17030332
23FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.15588703
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11946487
25GBX2_23144817_ChIP-Seq_PC3_Human2.10502943
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08634561
27JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08550105
28EZH2_27304074_Chip-Seq_ESCs_Mouse2.08157040
29DROSHA_22980978_ChIP-Seq_HELA_Human2.07882336
30MTF2_20144788_ChIP-Seq_MESCs_Mouse2.06146612
31ERG_21242973_ChIP-ChIP_JURKAT_Human2.04411022
32EZH2_27294783_Chip-Seq_ESCs_Mouse2.01125623
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97383090
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93896269
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.92806437
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.88924268
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86015398
38ZFP281_18757296_ChIP-ChIP_E14_Mouse1.86000364
39NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.85435466
40SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.83708329
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82490100
42RNF2_27304074_Chip-Seq_ESCs_Mouse1.77676046
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.76246115
44P300_19829295_ChIP-Seq_ESCs_Human1.71803737
45EWS_26573619_Chip-Seq_HEK293_Human1.70765340
46RNF2_27304074_Chip-Seq_NSC_Mouse1.68336149
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67366963
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.60678610
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59020816
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57582048
51KDM2B_26808549_Chip-Seq_K562_Human1.53927167
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.53734332
53CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51768060
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51737950
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.49258610
56WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48707688
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46146777
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45643516
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45471131
60* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.45355791
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43006888
62TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39852075
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38889834
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35982484
65ZNF263_19887448_ChIP-Seq_K562_Human1.34758204
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34619798
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.33701080
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.33021814
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32673161
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28845305
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.28307295
72SOX9_26525672_Chip-Seq_HEART_Mouse1.27703538
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24013301
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23659819
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23659819
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.23214944
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.22953767
78* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22880532
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21946642
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20522927
81ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19442380
82OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19300750
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.18913851
84* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18761981
85AR_19668381_ChIP-Seq_PC3_Human1.18751920
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17708531
87CTCF_27219007_Chip-Seq_Bcells_Human1.17531009
88FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17406403
89TBX3_20139965_ChIP-Seq_MESCs_Mouse1.17319672
90POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.17130107
91NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.16949438
92TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16810377
93STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16628674
94TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16165442
95ZNF274_21170338_ChIP-Seq_K562_Hela1.15306318
96* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14618573
97* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13684054
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.13407519
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11309691
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.10692098
101IKZF1_21737484_ChIP-ChIP_HCT116_Human1.09967551
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09578799
103STAT6_21828071_ChIP-Seq_BEAS2B_Human1.09513909
104KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09475167
105AR_25329375_ChIP-Seq_VCAP_Human1.08141571
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.07804718
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07769629
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06833059
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.06331215
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05673499
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04740684
112LXR_22292898_ChIP-Seq_THP-1_Human1.04345516
113TCF4_23295773_ChIP-Seq_U87_Human1.03578075
114* CLOCK_20551151_ChIP-Seq_293T_Human1.03155882
115CREB1_26743006_Chip-Seq_LNCaP_Human1.00678892
116* SMAD4_21741376_ChIP-Seq_HESCs_Human0.99383027
117NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98896780
118TAF15_26573619_Chip-Seq_HEK293_Human0.98841325
119MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98795808
120CBP_20019798_ChIP-Seq_JUKART_Human0.97003492
121IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97003492
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96988641
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.96903797
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96867554
125RUNX2_22187159_ChIP-Seq_PCA_Human0.96770691
126IRF1_19129219_ChIP-ChIP_H3396_Human0.96366205
127SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95918072
128ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.95320285
129CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95199890
130WT1_19549856_ChIP-ChIP_CCG9911_Human0.95042700
131MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.94859501
132TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.94529246
133PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.94504802
134PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94111573
135LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93744428
136CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93391957
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.92711097
138FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92653588
139NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92265801
140SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92181005
141EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91515223
142RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91340076
143* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91113050
144KLF4_19829295_ChIP-Seq_ESCs_Human0.90124684
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90090978
146SMAD4_21799915_ChIP-Seq_A2780_Human0.90047215
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89159836
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.88879164
149ISL1_27105846_Chip-Seq_CPCs_Mouse0.87869873
150ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86023454
151SMC4_20622854_ChIP-Seq_HELA_Human0.85591429
152MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85245076
153STAT3_23295773_ChIP-Seq_U87_Human0.84057453
154OCT4_19829295_ChIP-Seq_ESCs_Human0.83479676
155AR_21572438_ChIP-Seq_LNCaP_Human0.82902950
156KDM2B_26808549_Chip-Seq_SUP-B15_Human0.82063538
157SMAD3_21741376_ChIP-Seq_ESCs_Human0.80891351
158YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80259685
159* KDM2B_26808549_Chip-Seq_JURKAT_Human0.79198842
160TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79174516
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78430315
162WDR5_24793694_ChIP-Seq_LNCAP_Human0.77133835
163GATA1_26923725_Chip-Seq_HPCs_Mouse0.76779081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.17992816
2MP0002139_abnormal_hepatobiliary_system3.90916591
3MP0005360_urolithiasis3.18505572
4MP0005365_abnormal_bile_salt3.06474507
5MP0005085_abnormal_gallbladder_physiolo2.80785402
6MP0003635_abnormal_synaptic_transmissio2.75142991
7MP0003880_abnormal_central_pattern2.68260851
8MP0004270_analgesia2.49583622
9MP0002063_abnormal_learning/memory/cond2.34393082
10MP0010329_abnormal_lipoprotein_level2.18788699
11MP0001529_abnormal_vocalization2.11243988
12MP0002909_abnormal_adrenal_gland2.10687522
13MP0003195_calcinosis2.08701142
14MP0003329_amyloid_beta_deposits2.06514537
15MP0009780_abnormal_chondrocyte_physiolo1.98169459
16MP0004885_abnormal_endolymph1.94703309
17MP0009745_abnormal_behavioral_response1.92326487
18MP0008875_abnormal_xenobiotic_pharmacok1.91186130
19MP0005423_abnormal_somatic_nervous1.87022825
20MP0002064_seizures1.86317330
21MP0002822_catalepsy1.84214512
22MP0002572_abnormal_emotion/affect_behav1.81453639
23MP0008877_abnormal_DNA_methylation1.80200556
24MP0003252_abnormal_bile_duct1.78229083
25MP0000778_abnormal_nervous_system1.78064014
26MP0003122_maternal_imprinting1.75145505
27MP0006276_abnormal_autonomic_nervous1.72343263
28MP0000013_abnormal_adipose_tissue1.62670884
29MP0003283_abnormal_digestive_organ1.61885370
30MP0002837_dystrophic_cardiac_calcinosis1.60204857
31MP0002272_abnormal_nervous_system1.56551201
32MP0006072_abnormal_retinal_apoptosis1.54719565
33MP0001486_abnormal_startle_reflex1.53859880
34MP0002938_white_spotting1.50885619
35MP0003937_abnormal_limbs/digits/tail_de1.50196875
36MP0000566_synostosis1.49031883
37MP0002736_abnormal_nociception_after1.48087384
38MP0004133_heterotaxia1.46525123
39MP0002638_abnormal_pupillary_reflex1.46461268
40MP0001188_hyperpigmentation1.46213536
41MP0000955_abnormal_spinal_cord1.45515987
42MP0002733_abnormal_thermal_nociception1.44624567
43MP0005332_abnormal_amino_acid1.40214229
44MP0002734_abnormal_mechanical_nocicepti1.38716239
45MP0002557_abnormal_social/conspecific_i1.38691612
46MP0004858_abnormal_nervous_system1.37943230
47MP0004130_abnormal_muscle_cell1.36561892
48MP0005670_abnormal_white_adipose1.36402303
49MP0009046_muscle_twitch1.36072221
50MP0002184_abnormal_innervation1.34995829
51MP0002118_abnormal_lipid_homeostasis1.31470868
52MP0004811_abnormal_neuron_physiology1.31384981
53MP0005499_abnormal_olfactory_system1.31370661
54MP0005394_taste/olfaction_phenotype1.31370661
55MP0001440_abnormal_grooming_behavior1.30775426
56MP0001299_abnormal_eye_distance/1.30329279
57MP0008789_abnormal_olfactory_epithelium1.28180486
58MP0000049_abnormal_middle_ear1.26825835
59MP0005646_abnormal_pituitary_gland1.26396171
60MP0006292_abnormal_olfactory_placode1.25861945
61MP0001968_abnormal_touch/_nociception1.24872554
62MP0002102_abnormal_ear_morphology1.24414916
63MP0003861_abnormal_nervous_system1.23523838
64MP0005253_abnormal_eye_physiology1.21801012
65MP0002233_abnormal_nose_morphology1.19745527
66MP0004924_abnormal_behavior1.18728618
67MP0005386_behavior/neurological_phenoty1.18728618
68MP0001293_anophthalmia1.17171108
69MP0002751_abnormal_autonomic_nervous1.17133800
70MP0008961_abnormal_basal_metabolism1.15098651
71MP0005248_abnormal_Harderian_gland1.14278219
72MP0005187_abnormal_penis_morphology1.13410680
73MP0002067_abnormal_sensory_capabilities1.11946292
74MP0002882_abnormal_neuron_morphology1.11439799
75MP0005535_abnormal_body_temperature1.10089643
76MP0000604_amyloidosis1.09903734
77MP0002078_abnormal_glucose_homeostasis1.09742511
78MP0003690_abnormal_glial_cell1.09073213
79MP0004043_abnormal_pH_regulation1.08845249
80MP0003136_yellow_coat_color1.08703970
81MP0002066_abnormal_motor_capabilities/c1.07778891
82MP0003890_abnormal_embryonic-extraembry1.06531046
83MP0001666_abnormal_nutrient_absorption1.05485421
84MP0005551_abnormal_eye_electrophysiolog1.04060928
85MP0001177_atelectasis1.04037533
86MP0002697_abnormal_eye_size1.03741865
87MP0005645_abnormal_hypothalamus_physiol1.03709400
88MP0002152_abnormal_brain_morphology1.03148986
89MP0003938_abnormal_ear_development1.02729849
90MP0003567_abnormal_fetal_cardiomyocyte1.02604784
91MP0003879_abnormal_hair_cell1.02295590
92MP0002234_abnormal_pharynx_morphology1.01695652
93MP0004233_abnormal_muscle_weight1.01563391
94MP0001970_abnormal_pain_threshold1.00984217
95MP0001346_abnormal_lacrimal_gland1.00165340
96MP0003633_abnormal_nervous_system1.00065075
97MP0005083_abnormal_biliary_tract0.99254799
98MP0002069_abnormal_eating/drinking_beha0.98800974
99MP0009840_abnormal_foam_cell0.98545400
100MP0005367_renal/urinary_system_phenotyp0.98509860
101MP0000516_abnormal_urinary_system0.98509860
102MP0000537_abnormal_urethra_morphology0.98321984
103MP0001501_abnormal_sleep_pattern0.98036964
104MP0003119_abnormal_digestive_system0.97577635
105MP0003755_abnormal_palate_morphology0.97491429
106MP0002752_abnormal_somatic_nervous0.96578337
107MP0001286_abnormal_eye_development0.95454177
108MP0001984_abnormal_olfaction0.94904428
109MP0003942_abnormal_urinary_system0.94442276
110MP0000647_abnormal_sebaceous_gland0.92099573
111MP0003385_abnormal_body_wall0.91891086
112MP0000003_abnormal_adipose_tissue0.91851687
113MP0005391_vision/eye_phenotype0.91765930
114MP0008569_lethality_at_weaning0.89119266
115MP0002653_abnormal_ependyma_morphology0.88636347
116MP0000534_abnormal_ureter_morphology0.87657058
117MP0001502_abnormal_circadian_rhythm0.87498976
118MP0001485_abnormal_pinna_reflex0.87481458
119MP0000751_myopathy0.86825835
120MP0000026_abnormal_inner_ear0.86681912
121MP0003137_abnormal_impulse_conducting0.85839445
122MP0010030_abnormal_orbit_morphology0.85796220
123MP0003868_abnormal_feces_composition0.85280139
124MP0003631_nervous_system_phenotype0.85073794
125MP0002229_neurodegeneration0.84588638
126MP0008995_early_reproductive_senescence0.83294552
127MP0000609_abnormal_liver_physiology0.82973965
128MP0004145_abnormal_muscle_electrophysio0.82496350
129MP0009703_decreased_birth_body0.82050612
130MP0004142_abnormal_muscle_tone0.82044933
131MP0003806_abnormal_nucleotide_metabolis0.81715678
132MP0005666_abnormal_adipose_tissue0.81619064
133MP0003953_abnormal_hormone_level0.81458709
134MP0000631_abnormal_neuroendocrine_gland0.81406628
135MP0003634_abnormal_glial_cell0.80702440
136MP0003787_abnormal_imprinting0.80472748
137MP0000639_abnormal_adrenal_gland0.80183806
138MP0003123_paternal_imprinting0.79216597
139MP0003315_abnormal_perineum_morphology0.78823003
140MP0002081_perinatal_lethality0.78707153
141MP0005375_adipose_tissue_phenotype0.77758087
142MP0003121_genomic_imprinting0.77425413
143MP0005584_abnormal_enzyme/coenzyme_acti0.77192949
144MP0008058_abnormal_DNA_repair0.77148774
145MP0001944_abnormal_pancreas_morphology0.76423652
146MP0002084_abnormal_developmental_patter0.76026917
147MP0003935_abnormal_craniofacial_develop0.75287715
148MP0004085_abnormal_heartbeat0.75251394
149MP0003632_abnormal_nervous_system0.74545021
150MP0005448_abnormal_energy_balance0.74497845
151MP0001963_abnormal_hearing_physiology0.74399944
152MP0002735_abnormal_chemical_nociception0.73668338

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.03066463
2Deep venous thrombosis (HP:0002625)3.84047685
3Abnormality of aromatic amino acid family metabolism (HP:0004338)3.69241882
4Abnormality of the lower motor neuron (HP:0002366)3.34672659
5Intrahepatic cholestasis (HP:0001406)3.25121808
6Pheochromocytoma (HP:0002666)3.21461124
7Ketosis (HP:0001946)3.08057184
8Ankle clonus (HP:0011448)3.08014283
9Visual hallucinations (HP:0002367)3.01906703
10Ketoacidosis (HP:0001993)3.00585478
11Xanthomatosis (HP:0000991)2.96335362
12Abnormality of the labia minora (HP:0012880)2.93719768
13Focal motor seizures (HP:0011153)2.87545950
14Supranuclear gaze palsy (HP:0000605)2.81923456
15Focal seizures (HP:0007359)2.78505962
16Hypoglycemic seizures (HP:0002173)2.77280704
17Gait imbalance (HP:0002141)2.77005027
18Hypoglycemic coma (HP:0001325)2.76696532
19Agitation (HP:0000713)2.74580108
20Neuroendocrine neoplasm (HP:0100634)2.72605062
21Cerebral inclusion bodies (HP:0100314)2.70878079
22Complement deficiency (HP:0004431)2.70125840
23Abnormality of monocarboxylic acid metabolism (HP:0010996)2.68654476
24Neurofibrillary tangles (HP:0002185)2.65935611
25Hyperlipoproteinemia (HP:0010980)2.63906376
26Insomnia (HP:0100785)2.62260107
27Depression (HP:0000716)2.57734884
28Hyperventilation (HP:0002883)2.51260660
29Hypobetalipoproteinemia (HP:0003563)2.50595464
30Congenital primary aphakia (HP:0007707)2.48162748
31Hyperinsulinemic hypoglycemia (HP:0000825)2.47139674
32Cortical dysplasia (HP:0002539)2.46287648
33Torticollis (HP:0000473)2.45366550
34Abnormal social behavior (HP:0012433)2.42452747
35Impaired social interactions (HP:0000735)2.42452747
36Epidermoid cyst (HP:0200040)2.41612013
37Genital tract atresia (HP:0001827)2.40977959
38Action tremor (HP:0002345)2.40235780
39Poor eye contact (HP:0000817)2.40201418
40Focal dystonia (HP:0004373)2.39320798
41Vaginal atresia (HP:0000148)2.38459791
42Medial flaring of the eyebrow (HP:0010747)2.37783491
43Clonus (HP:0002169)2.36798227
44Nephrogenic diabetes insipidus (HP:0009806)2.34771826
45Hypsarrhythmia (HP:0002521)2.31500331
46Craniofacial dystonia (HP:0012179)2.28893683
47EEG with generalized epileptiform discharges (HP:0011198)2.27329456
48Hyperammonemia (HP:0001987)2.26104100
49Excessive salivation (HP:0003781)2.25916846
50Drooling (HP:0002307)2.25916846
51Prolonged partial thromboplastin time (HP:0003645)2.25774455
52Intestinal atresia (HP:0011100)2.24593306
53Skin nodule (HP:0200036)2.24545001
54Spastic gait (HP:0002064)2.21717095
55Generalized tonic-clonic seizures (HP:0002069)2.20965664
56Epileptiform EEG discharges (HP:0011182)2.19372695
57Elfin facies (HP:0004428)2.18574245
58Renovascular hypertension (HP:0100817)2.18335697
59Anxiety (HP:0000739)2.15978344
60Delayed CNS myelination (HP:0002188)2.15910342
61Dysdiadochokinesis (HP:0002075)2.15821172
62True hermaphroditism (HP:0010459)2.14977770
63Hyperglycinemia (HP:0002154)2.13816327
64Neoplasm of the heart (HP:0100544)2.11772730
65Specific learning disability (HP:0001328)2.10765983
66Progressive cerebellar ataxia (HP:0002073)2.10332257
67Turricephaly (HP:0000262)2.09646171
68Impaired vibration sensation in the lower limbs (HP:0002166)2.09499282
69Lissencephaly (HP:0001339)2.08741679
70Shoulder girdle muscle weakness (HP:0003547)2.06781702
71Hyperacusis (HP:0010780)2.06748676
72Tubulointerstitial nephritis (HP:0001970)2.06262040
73Hyperglycinuria (HP:0003108)2.05979573
74Neoplasm of the peripheral nervous system (HP:0100007)2.05395003
75Urinary urgency (HP:0000012)2.04489970
76Abnormality of serine family amino acid metabolism (HP:0010894)2.04381763
77Abnormality of glycine metabolism (HP:0010895)2.04381763
78Hypolipoproteinemia (HP:0010981)2.04130438
79Colon cancer (HP:0003003)2.04040568
80Hypoalphalipoproteinemia (HP:0003233)2.00884953
81Late onset (HP:0003584)2.00666564
82Lymphangioma (HP:0100764)2.00552368
83Intention tremor (HP:0002080)1.98930041
84Status epilepticus (HP:0002133)1.98917306
85Neonatal onset (HP:0003623)1.98092647
86Broad-based gait (HP:0002136)1.96551893
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95791443
88Scanning speech (HP:0002168)1.95664137
89Hepatoblastoma (HP:0002884)1.94864343
90Pancreatic fibrosis (HP:0100732)1.94591126
91Truncal ataxia (HP:0002078)1.94361467
92Abnormality of the hip-girdle musculature (HP:0001445)1.93909855
93Abnormality of the musculature of the pelvis (HP:0001469)1.93909855
94Poor coordination (HP:0002370)1.93525678
95Morphological abnormality of the pyramidal tract (HP:0002062)1.93248362
96Abnormal eating behavior (HP:0100738)1.92818648
97Oligodactyly (hands) (HP:0001180)1.92741631
98Renal hypoplasia (HP:0000089)1.92261361
99Hemiparesis (HP:0001269)1.91571536
100Degeneration of the lateral corticospinal tracts (HP:0002314)1.91449802
101Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.91449802
102Amyotrophic lateral sclerosis (HP:0007354)1.90815432
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.90289308
104Spastic tetraplegia (HP:0002510)1.89800237
105Nephronophthisis (HP:0000090)1.88729575
106Pancreatic cysts (HP:0001737)1.88722919
107Epileptic encephalopathy (HP:0200134)1.88144375
108Atonic seizures (HP:0010819)1.88073515
109Termporal pattern (HP:0011008)1.87192608
110Insidious onset (HP:0003587)1.87192608
111Postaxial hand polydactyly (HP:0001162)1.86548694
112Symptomatic seizures (HP:0011145)1.85778350
113Cutaneous finger syndactyly (HP:0010554)1.85690326
114Restlessness (HP:0000711)1.83408480
115Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.81111173
116Limb dystonia (HP:0002451)1.80755675
117Hemiplegia (HP:0002301)1.80511740
118Optic nerve hypoplasia (HP:0000609)1.79847968
119Volvulus (HP:0002580)1.78453448
120Abnormality of the common coagulation pathway (HP:0010990)1.78383697
121Oligomenorrhea (HP:0000876)1.78204140
122Macroorchidism (HP:0000053)1.78109225
123Short tibia (HP:0005736)1.77939599
124Hemangiomatosis (HP:0007461)1.77853751
125Absence seizures (HP:0002121)1.77412847
126Dysmetria (HP:0001310)1.76747732
127Abnormality of the astrocytes (HP:0100707)1.75535252
128Astrocytoma (HP:0009592)1.75535252
129Urinary bladder sphincter dysfunction (HP:0002839)1.75267000
130Bifid tongue (HP:0010297)1.75015282
131Hyperglycemia (HP:0003074)1.75000705
132Hypoventilation (HP:0002791)1.74844661
133Postural instability (HP:0002172)1.74398971
134Aplasia/Hypoplasia of the sternum (HP:0006714)1.73883981
135Blue irides (HP:0000635)1.73806405
136Split foot (HP:0001839)1.73561827
137Molar tooth sign on MRI (HP:0002419)1.73286950
138Abnormality of midbrain morphology (HP:0002418)1.73286950
139Type II lissencephaly (HP:0007260)1.72835973
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.72289544
141Abnormality of the corticospinal tract (HP:0002492)1.71889947
142Retinal dysplasia (HP:0007973)1.71742700
143Labial hypoplasia (HP:0000066)1.71641928
144Gout (HP:0001997)1.71013004
145Micropenis (HP:0000054)1.67835960
146Polyphagia (HP:0002591)1.67249655
147Septo-optic dysplasia (HP:0100842)1.67170931
148Broad foot (HP:0001769)1.66890910
149Preaxial hand polydactyly (HP:0001177)1.66820240
150Febrile seizures (HP:0002373)1.65514946
151Medulloblastoma (HP:0002885)1.64784987
152Cutaneous syndactyly (HP:0012725)1.64483407
153Gastrointestinal atresia (HP:0002589)1.64478253
154Anophthalmia (HP:0000528)1.64030423
155Dialeptic seizures (HP:0011146)1.63500008
156Neoplasm of the oral cavity (HP:0100649)1.62849312
157Hypoplastic female external genitalia (HP:0012815)1.60171994
158Postaxial foot polydactyly (HP:0001830)1.59963941
159Abnormality of the metopic suture (HP:0005556)1.59903919
160Glioma (HP:0009733)1.59291405
161Ependymoma (HP:0002888)1.59114578
162Oligodactyly (HP:0012165)1.58649029
163Pachygyria (HP:0001302)1.57603954
164Absent eyebrow (HP:0002223)1.56871607
165Scrotal hypoplasia (HP:0000046)1.56856105
166Narrow forehead (HP:0000341)1.55511314
167Failure to thrive in infancy (HP:0001531)1.55033561
168Absent speech (HP:0001344)1.53839184
169Decreased testicular size (HP:0008734)1.53174587
170Rimmed vacuoles (HP:0003805)1.51011530
171Abnormality of the renal medulla (HP:0100957)1.49483373
172Aplasia/Hypoplasia of the brainstem (HP:0007362)1.47642534
173Hypoplasia of the brainstem (HP:0002365)1.47642534
174Aqueductal stenosis (HP:0002410)1.46780988
175Abnormal lung lobation (HP:0002101)1.45634273

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.07064682
2MARK13.71478376
3NTRK33.11546113
4MAP3K92.95997948
5MAP3K42.95286646
6WNK32.77422255
7EPHA42.58918048
8TRIB32.29594727
9PRKD32.28435508
10MINK12.23296371
11NTRK12.18864988
12KSR12.04886087
13MAP2K42.04556414
14DAPK22.03876675
15KSR22.01830822
16NTRK21.99318224
17SRPK11.95022057
18PAK61.90779829
19MAP4K21.79427237
20TRIM281.77641876
21TYRO31.67442629
22PNCK1.62302437
23TSSK61.60036130
24ICK1.57028441
25INSRR1.55955099
26MAP2K71.52179431
27UHMK11.50119608
28PINK11.44734150
29PHKG11.44276131
30PHKG21.44276131
31LATS21.42822367
32BCKDK1.34378704
33STK38L1.32890757
34RIPK11.31440193
35CAMK1G1.30992443
36WNK11.27568197
37SIK11.25309747
38PKN21.23875826
39CAMKK11.21107331
40EPHA31.20519694
41TNIK1.20340842
42CDK51.20097519
43AKT31.19498993
44MKNK21.18189854
45EPHB21.14074625
46RET1.13976062
47PLK21.13480288
48PDGFRA1.12651205
49MKNK11.12518745
50LMTK21.12185342
51BMPR1B1.09264481
52SGK4941.07674998
53SGK2231.07674998
54PAK31.05743572
55MAP3K21.04324233
56ALK1.02801106
57PLK31.02076168
58BRD40.99950310
59FRK0.99589009
60STK380.98107655
61MAPK130.96413608
62ZAK0.94141829
63LATS10.92969708
64SIK20.89756535
65CDK190.89454287
66CDC70.89222184
67DYRK30.87831565
68PRKCG0.87740181
69BRSK20.87577155
70CSNK1G20.86757448
71CDC42BPA0.86533669
72ERBB20.83734706
73FGFR20.83571752
74PRKCH0.82921871
75PRKCE0.79674613
76TTK0.77802175
77DYRK20.75101581
78PRKCZ0.74403191
79WEE10.74071033
80WNK40.71462707
81NEK10.70273315
82CDK140.69580332
83PLK40.68925062
84STK110.67959804
85PASK0.67850610
86DAPK10.67608800
87BCR0.67250236
88CDK180.67215552
89CDK150.66310248
90SGK30.66260421
91DYRK1B0.66106334
92PLK10.65260645
93CDK30.64292808
94LIMK10.64262930
95PTK60.63906754
96STK390.63660395
97MARK20.63487895
98PDPK10.62429323
99MAP2K10.62188781
100OXSR10.61406094
101CSNK1G30.60772682
102FER0.59224870
103NUAK10.58666111
104PKN10.57731541
105SGK20.57531982
106CDK11A0.57343150
107GRK10.56908910
108CSNK1A1L0.56700246
109MAPK150.56296868
110PTK20.55688968
111MTOR0.55490343
112MAP3K100.54531128
113VRK10.53053055
114CAMK1D0.53047326
115RPS6KA30.53027040
116RPS6KA40.52035534
117PRKACG0.50048786
118CAMK10.49704069
119CSNK1D0.49484280
120ATR0.48230403
121GRK50.48212132
122CAMK2A0.48034878
123MAP3K10.48004729
124ERBB30.47229387
125ATM0.45815950
126CAMKK20.45772448
127TIE10.45355422
128SGK10.45097365
129RPS6KA20.45047307
130PRKAA10.44728959
131SCYL20.44228692
132PDK10.44041470
133FGFR40.43730861
134OBSCN0.43645157
135NEK60.43395198
136PRKDC0.42810468
137CSNK1G10.42292456
138CAMK2B0.41796730
139DYRK1A0.41782688
140CAMK40.41544486
141CSNK1E0.41252501
142CAMK2D0.41226217
143CHEK20.40772296
144CCNB10.40508187
145ERBB40.40304470
146MAPK100.37260594
147BRSK10.36871487
148FGFR10.36868689

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.67526547
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.71889055
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.40804777
4Butanoate metabolism_Homo sapiens_hsa006502.32782552
5Arginine biosynthesis_Homo sapiens_hsa002202.21766939
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.16418897
7Steroid biosynthesis_Homo sapiens_hsa001002.10760239
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91572023
9Fatty acid degradation_Homo sapiens_hsa000711.84062063
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82917061
11Fatty acid metabolism_Homo sapiens_hsa012121.77353134
12Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73558546
13Tryptophan metabolism_Homo sapiens_hsa003801.70755867
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70090495
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67201381
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62672644
17Propanoate metabolism_Homo sapiens_hsa006401.62475044
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62094905
19GABAergic synapse_Homo sapiens_hsa047271.61036202
20Protein export_Homo sapiens_hsa030601.54818872
21Synaptic vesicle cycle_Homo sapiens_hsa047211.53018066
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.52412365
23PPAR signaling pathway_Homo sapiens_hsa033201.50851474
24Bile secretion_Homo sapiens_hsa049761.47964029
25Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46600229
26Nicotine addiction_Homo sapiens_hsa050331.44135344
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.43800206
28Non-homologous end-joining_Homo sapiens_hsa034501.40010762
29Insulin secretion_Homo sapiens_hsa049111.36511697
30Hedgehog signaling pathway_Homo sapiens_hsa043401.33739135
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33640383
32Hippo signaling pathway_Homo sapiens_hsa043901.32969115
33Basal cell carcinoma_Homo sapiens_hsa052171.31579172
34Circadian entrainment_Homo sapiens_hsa047131.28735279
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28023350
36Complement and coagulation cascades_Homo sapiens_hsa046101.26705587
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26416892
38Vitamin B6 metabolism_Homo sapiens_hsa007501.24999549
39Glutamatergic synapse_Homo sapiens_hsa047241.20476246
40Dopaminergic synapse_Homo sapiens_hsa047281.18576949
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18151092
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16318520
43Olfactory transduction_Homo sapiens_hsa047401.15725169
44Pyruvate metabolism_Homo sapiens_hsa006201.15655822
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14643745
46Long-term potentiation_Homo sapiens_hsa047201.14488640
47Circadian rhythm_Homo sapiens_hsa047101.12381700
48Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12284776
49beta-Alanine metabolism_Homo sapiens_hsa004101.10826135
50Amphetamine addiction_Homo sapiens_hsa050311.10317670
51Morphine addiction_Homo sapiens_hsa050321.08333808
52Type II diabetes mellitus_Homo sapiens_hsa049301.07567917
53Lysine degradation_Homo sapiens_hsa003101.04593453
54Oocyte meiosis_Homo sapiens_hsa041141.04553446
55Basal transcription factors_Homo sapiens_hsa030221.04242094
56Cocaine addiction_Homo sapiens_hsa050301.02493407
57Fatty acid elongation_Homo sapiens_hsa000621.00820484
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98555311
59Phototransduction_Homo sapiens_hsa047440.97927922
60Peroxisome_Homo sapiens_hsa041460.94251203
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92464260
62Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92427339
63Fatty acid biosynthesis_Homo sapiens_hsa000610.91946646
64Cholinergic synapse_Homo sapiens_hsa047250.91746874
65Fanconi anemia pathway_Homo sapiens_hsa034600.91677255
66Cardiac muscle contraction_Homo sapiens_hsa042600.89225781
67Prion diseases_Homo sapiens_hsa050200.88210176
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88044940
69Glucagon signaling pathway_Homo sapiens_hsa049220.87752389
70Wnt signaling pathway_Homo sapiens_hsa043100.87383149
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87129994
72Biosynthesis of amino acids_Homo sapiens_hsa012300.86496555
73Mismatch repair_Homo sapiens_hsa034300.86198372
74Gap junction_Homo sapiens_hsa045400.84973509
75Renin secretion_Homo sapiens_hsa049240.83853674
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83790061
77RNA degradation_Homo sapiens_hsa030180.83368153
78Tight junction_Homo sapiens_hsa045300.82921152
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82596579
80RNA transport_Homo sapiens_hsa030130.81846572
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80922073
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80504895
83Carbon metabolism_Homo sapiens_hsa012000.80270019
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79927173
85Salivary secretion_Homo sapiens_hsa049700.79909775
86Phenylalanine metabolism_Homo sapiens_hsa003600.79717858
87Axon guidance_Homo sapiens_hsa043600.79483183
88Spliceosome_Homo sapiens_hsa030400.78936714
89mRNA surveillance pathway_Homo sapiens_hsa030150.78408736
90Estrogen signaling pathway_Homo sapiens_hsa049150.77221706
91Tyrosine metabolism_Homo sapiens_hsa003500.76306762
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75688779
93Regulation of autophagy_Homo sapiens_hsa041400.75665534
94Dorso-ventral axis formation_Homo sapiens_hsa043200.75377769
95Fat digestion and absorption_Homo sapiens_hsa049750.74226088
96Gastric acid secretion_Homo sapiens_hsa049710.73868947
97Taste transduction_Homo sapiens_hsa047420.73500630
98Glycerolipid metabolism_Homo sapiens_hsa005610.71860903
99RNA polymerase_Homo sapiens_hsa030200.71481897
100Selenocompound metabolism_Homo sapiens_hsa004500.71169754
101Nucleotide excision repair_Homo sapiens_hsa034200.70075042
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.69991806
103Insulin signaling pathway_Homo sapiens_hsa049100.69679905
104Alcoholism_Homo sapiens_hsa050340.69547900
105Oxidative phosphorylation_Homo sapiens_hsa001900.66564113
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64919643
107AMPK signaling pathway_Homo sapiens_hsa041520.64678100
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64554560
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.64471062
110Arginine and proline metabolism_Homo sapiens_hsa003300.64298514
111GnRH signaling pathway_Homo sapiens_hsa049120.64048390
112TGF-beta signaling pathway_Homo sapiens_hsa043500.63761167
113ABC transporters_Homo sapiens_hsa020100.61865351
114Long-term depression_Homo sapiens_hsa047300.61742268
115Histidine metabolism_Homo sapiens_hsa003400.60510191
116Glioma_Homo sapiens_hsa052140.60386998
117Oxytocin signaling pathway_Homo sapiens_hsa049210.60203121
118Sulfur metabolism_Homo sapiens_hsa009200.58588397
119Parkinsons disease_Homo sapiens_hsa050120.57739248
120cAMP signaling pathway_Homo sapiens_hsa040240.56699771
121Cell cycle_Homo sapiens_hsa041100.56508211
122Base excision repair_Homo sapiens_hsa034100.55231038
123Melanogenesis_Homo sapiens_hsa049160.55086188
124Huntingtons disease_Homo sapiens_hsa050160.54826188
125Insulin resistance_Homo sapiens_hsa049310.54147403
126Vibrio cholerae infection_Homo sapiens_hsa051100.51957444
127Adherens junction_Homo sapiens_hsa045200.50978417
128Thyroid hormone synthesis_Homo sapiens_hsa049180.50904650
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50706078
130Folate biosynthesis_Homo sapiens_hsa007900.50550482
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.50228800
132Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49270661
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.48114676
134ErbB signaling pathway_Homo sapiens_hsa040120.47402794
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46940438
136Retinol metabolism_Homo sapiens_hsa008300.46581068
137Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46281438
138Starch and sucrose metabolism_Homo sapiens_hsa005000.46273639
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45689930
140Alzheimers disease_Homo sapiens_hsa050100.45296702
141Chemical carcinogenesis_Homo sapiens_hsa052040.45229203
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.45164644
143Ovarian steroidogenesis_Homo sapiens_hsa049130.44772326
144Serotonergic synapse_Homo sapiens_hsa047260.44325601
145cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44116611
146Endometrial cancer_Homo sapiens_hsa052130.44094237

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