FBXO22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)4.90229795
2nucleobase biosynthetic process (GO:0046112)4.81628712
3glycine metabolic process (GO:0006544)4.62188385
4folic acid-containing compound biosynthetic process (GO:0009396)4.49746629
5IMP biosynthetic process (GO:0006188)4.00601703
6serine family amino acid biosynthetic process (GO:0009070)3.99053854
7formation of translation preinitiation complex (GO:0001731)3.86872731
8serine family amino acid catabolic process (GO:0009071)3.84838801
9replication fork processing (GO:0031297)3.83729997
10serine family amino acid metabolic process (GO:0009069)3.82509496
11folic acid metabolic process (GO:0046655)3.80453239
12somatic diversification of immune receptors via somatic mutation (GO:0002566)3.71252579
13somatic hypermutation of immunoglobulin genes (GO:0016446)3.71252579
14tetrahydrofolate metabolic process (GO:0046653)3.69867071
15L-phenylalanine metabolic process (GO:0006558)3.66237731
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.66237731
17DNA unwinding involved in DNA replication (GO:0006268)3.57271629
18DNA strand elongation involved in DNA replication (GO:0006271)3.56441019
19DNA replication initiation (GO:0006270)3.55621737
20regulation of posttranscriptional gene silencing (GO:0060147)3.52574824
21regulation of gene silencing by miRNA (GO:0060964)3.52574824
22regulation of gene silencing by RNA (GO:0060966)3.52574824
23glyoxylate metabolic process (GO:0046487)3.49296771
24DNA replication-dependent nucleosome assembly (GO:0006335)3.48894907
25DNA replication-dependent nucleosome organization (GO:0034723)3.48894907
26regulation of centriole replication (GO:0046599)3.47545131
27DNA double-strand break processing (GO:0000729)3.45141128
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43695616
29L-phenylalanine catabolic process (GO:0006559)3.43695616
30pteridine-containing compound biosynthetic process (GO:0042559)3.40714254
31L-serine metabolic process (GO:0006563)3.40347935
32DNA strand elongation (GO:0022616)3.39313146
33ribosome assembly (GO:0042255)3.37223918
34IMP metabolic process (GO:0046040)3.37188504
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.34205733
36lysine metabolic process (GO:0006553)3.34010133
37lysine catabolic process (GO:0006554)3.34010133
38telomere maintenance via semi-conservative replication (GO:0032201)3.32214051
39cysteine metabolic process (GO:0006534)3.32037023
40aromatic amino acid family catabolic process (GO:0009074)3.29686429
41ribosome biogenesis (GO:0042254)3.27972715
42regulation of mitotic spindle checkpoint (GO:1903504)3.24356696
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24356696
44histone exchange (GO:0043486)3.23888600
45meiotic chromosome segregation (GO:0045132)3.23034669
46DNA replication checkpoint (GO:0000076)3.20806700
47folic acid-containing compound metabolic process (GO:0006760)3.17992403
48indole-containing compound catabolic process (GO:0042436)3.15648480
49indolalkylamine catabolic process (GO:0046218)3.15648480
50tryptophan catabolic process (GO:0006569)3.15648480
51regulation of helicase activity (GO:0051095)3.13040597
52homocysteine metabolic process (GO:0050667)3.12814700
53water-soluble vitamin biosynthetic process (GO:0042364)3.12481098
54mitotic metaphase plate congression (GO:0007080)3.12468385
55maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.11557636
56kinetochore organization (GO:0051383)3.10558009
57rRNA modification (GO:0000154)3.10541298
58regulation of mitochondrial translation (GO:0070129)3.08666543
59kynurenine metabolic process (GO:0070189)3.08660043
60double-strand break repair via homologous recombination (GO:0000724)3.08383583
61recombinational repair (GO:0000725)3.07730265
62one-carbon metabolic process (GO:0006730)3.07096476
63tryptophan metabolic process (GO:0006568)3.06864774
64mitotic nuclear envelope disassembly (GO:0007077)3.04323544
65sulfur amino acid catabolic process (GO:0000098)3.01612935
66regulation of centrosome cycle (GO:0046605)3.01143575
67chromatin remodeling at centromere (GO:0031055)3.00167505
68maturation of SSU-rRNA (GO:0030490)2.95547644
69imidazole-containing compound metabolic process (GO:0052803)2.95413239
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93863636
71establishment of protein localization to mitochondrial membrane (GO:0090151)2.93769057
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93156123
73aldehyde catabolic process (GO:0046185)2.92692090
74nuclear pore organization (GO:0006999)2.92626700
75regulation of centrosome duplication (GO:0010824)2.92115614
76centriole replication (GO:0007099)2.91878936
77pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.89273651
78regulation of DNA endoreduplication (GO:0032875)2.89003928
79mitochondrial respiratory chain complex assembly (GO:0033108)2.88474434
80regulation of nuclear cell cycle DNA replication (GO:0033262)2.87322410
81proline biosynthetic process (GO:0006561)2.85238308
82telomere maintenance via recombination (GO:0000722)2.84874185
83CENP-A containing nucleosome assembly (GO:0034080)2.83602910
84reciprocal DNA recombination (GO:0035825)2.83513313
85reciprocal meiotic recombination (GO:0007131)2.83513313
86protein complex biogenesis (GO:0070271)2.82906539
87DNA strand renaturation (GO:0000733)2.82856642
88pteridine-containing compound metabolic process (GO:0042558)2.82757474
89kinetochore assembly (GO:0051382)2.82431338
90non-recombinational repair (GO:0000726)2.78488172
91double-strand break repair via nonhomologous end joining (GO:0006303)2.78488172
92proteasome assembly (GO:0043248)2.77980182
93peptidyl-histidine modification (GO:0018202)2.77553476
94ethanol oxidation (GO:0006069)2.76640882
95membrane disassembly (GO:0030397)2.76342427
96nuclear envelope disassembly (GO:0051081)2.76342427
97alpha-amino acid catabolic process (GO:1901606)2.76322754
98telomere maintenance via telomere lengthening (GO:0010833)2.76232703
99behavioral response to nicotine (GO:0035095)2.75618273
100respiratory chain complex IV assembly (GO:0008535)2.74388938
101synapsis (GO:0007129)2.73188494
102spliceosomal snRNP assembly (GO:0000387)2.72493392
103viral mRNA export from host cell nucleus (GO:0046784)2.72123927
104ribonucleoprotein complex biogenesis (GO:0022613)2.70593007
105rRNA methylation (GO:0031167)2.69208304
106mitotic recombination (GO:0006312)2.68179478
107nuclear pore complex assembly (GO:0051292)2.67959368
108RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.67309700
109mitochondrial respiratory chain complex I assembly (GO:0032981)2.67304277
110NADH dehydrogenase complex assembly (GO:0010257)2.67304277
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67304277
112sulfur amino acid biosynthetic process (GO:0000097)2.66610868
113monoubiquitinated protein deubiquitination (GO:0035520)2.66338650
114postreplication repair (GO:0006301)2.66079804
115UMP metabolic process (GO:0046049)2.65999545
116pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.65999545
117UMP biosynthetic process (GO:0006222)2.65999545
118pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.65999545
119histone arginine methylation (GO:0034969)2.65860544
120DNA geometric change (GO:0032392)2.64629655
121DNA duplex unwinding (GO:0032508)2.64025014
122aromatic amino acid family metabolic process (GO:0009072)2.63870863
123mitotic sister chromatid segregation (GO:0000070)2.63288887
124resolution of meiotic recombination intermediates (GO:0000712)2.63099746
125pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.62959041
126bile acid biosynthetic process (GO:0006699)2.62245168
127cytochrome complex assembly (GO:0017004)2.61052407
128maturation of 5.8S rRNA (GO:0000460)2.60730459
129pseudouridine synthesis (GO:0001522)2.60636551
130urea cycle (GO:0000050)2.60603716
131urea metabolic process (GO:0019627)2.60603716
132protein localization to kinetochore (GO:0034501)2.59731771
133regulation of hippo signaling (GO:0035330)2.59090891
134aspartate family amino acid metabolic process (GO:0009066)2.58757223
135DNA replication-independent nucleosome organization (GO:0034724)2.58726664
136DNA replication-independent nucleosome assembly (GO:0006336)2.58726664
137tRNA aminoacylation for protein translation (GO:0006418)2.57880900
138mitochondrial RNA metabolic process (GO:0000959)2.57691410
139triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.57059428
140somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.56209444
141isotype switching (GO:0045190)2.56209444
142somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.56209444
143metaphase plate congression (GO:0051310)2.54753558
144proline metabolic process (GO:0006560)2.54622899
145regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.53768546
146cellular amino acid catabolic process (GO:0009063)2.53674149
147spindle checkpoint (GO:0031577)2.53388929
148translesion synthesis (GO:0019985)2.53335927
149amino acid activation (GO:0043038)2.52897631
150DNA-dependent DNA replication (GO:0006261)2.52730256
151L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.52220018
152DNA catabolic process, exonucleolytic (GO:0000738)2.52082965
153centrosome organization (GO:0051297)2.51694653
154negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.50333103
155negative regulation of translation, ncRNA-mediated (GO:0040033)2.50333103
156regulation of translation, ncRNA-mediated (GO:0045974)2.50333103
157sister chromatid segregation (GO:0000819)2.50231455
158negative regulation of chromosome segregation (GO:0051985)2.48350101
159negative regulation of mitotic sister chromatid separation (GO:2000816)2.47618784
160negative regulation of sister chromatid segregation (GO:0033046)2.47618784
161negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.47618784
162negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.47618784
163negative regulation of mitotic sister chromatid segregation (GO:0033048)2.47618784
164mitotic spindle checkpoint (GO:0071174)2.46926392
165nucleotide-excision repair, DNA gap filling (GO:0006297)2.46013734
166somatic diversification of immunoglobulins (GO:0016445)2.43591441
167mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.43015026
168DNA recombination (GO:0006310)2.42701893
169somatic recombination of immunoglobulin gene segments (GO:0016447)2.41922313

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.01007412
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.19883357
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.35568050
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.14018779
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.99179927
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92693186
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85458163
8ZNF274_21170338_ChIP-Seq_K562_Hela2.84307775
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.83672840
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73773068
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.69617771
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.52676564
13FUS_26573619_Chip-Seq_HEK293_Human2.46883481
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.43710974
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.43687461
16EWS_26573619_Chip-Seq_HEK293_Human2.41344254
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.39876612
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35690662
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32597424
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.32306776
21* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23578099
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.22434490
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21958846
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21059022
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.10765117
26IGF1R_20145208_ChIP-Seq_DFB_Human2.07497812
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06713826
28NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01400407
29RXR_22158963_ChIP-Seq_LIVER_Mouse1.98965210
30XRN2_22483619_ChIP-Seq_HELA_Human1.97541056
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.97465050
32POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96547244
33* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.95423078
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.94144316
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.92338588
36AR_21909140_ChIP-Seq_LNCAP_Human1.91700185
37PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91129835
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.90488629
39MYC_18940864_ChIP-ChIP_HL60_Human1.90387993
40VDR_22108803_ChIP-Seq_LS180_Human1.89905895
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.88785484
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.84437468
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.83794818
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83429213
45DCP1A_22483619_ChIP-Seq_HELA_Human1.81185858
46TAF15_26573619_Chip-Seq_HEK293_Human1.80589276
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.79558325
48* VDR_23849224_ChIP-Seq_CD4+_Human1.79285447
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76439240
50* GABP_19822575_ChIP-Seq_HepG2_Human1.75819535
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.74708048
52E2F1_21310950_ChIP-Seq_MCF-7_Human1.73315414
53HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72782338
54FOXP3_21729870_ChIP-Seq_TREG_Human1.72413585
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71425949
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71425949
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71425949
58ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69961449
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.67192692
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.67031773
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.66026404
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65694511
63GBX2_23144817_ChIP-Seq_PC3_Human1.64776796
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63068434
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61815136
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60622048
67IRF1_19129219_ChIP-ChIP_H3396_Human1.56957821
68HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54964417
69P300_19829295_ChIP-Seq_ESCs_Human1.54411893
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53537124
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51485400
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.50863280
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.49724668
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47337099
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47240684
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.46798224
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.46502283
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.44782452
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.44325551
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.40820356
81TTF2_22483619_ChIP-Seq_HELA_Human1.40175695
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38324427
83EGR1_19374776_ChIP-ChIP_THP-1_Human1.38232521
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.37383910
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.36136856
86KDM5A_27292631_Chip-Seq_BREAST_Human1.34939689
87MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.34308575
88ELK1_19687146_ChIP-ChIP_HELA_Human1.34209929
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34106847
90TP63_19390658_ChIP-ChIP_HaCaT_Human1.32359612
91CIITA_25753668_ChIP-Seq_RAJI_Human1.29043207
92NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.28917109
93CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28751746
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28254278
95* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.24468945
96ER_23166858_ChIP-Seq_MCF-7_Human1.23729996
97SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23710765
98MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23105232
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22963645
100* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.22600903
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22273266
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20977047
103ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18986992
104OCT4_18692474_ChIP-Seq_MEFs_Mouse1.17839063
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16664844
106* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16346273
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.15953799
108LXR_22158963_ChIP-Seq_LIVER_Mouse1.15632738
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15275293
110HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.14868971
111FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14854743
112KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14020378
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12904369
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12540717
115SOX2_16153702_ChIP-ChIP_HESCs_Human1.11884593
116PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11719189
117* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11017276
118SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07427094
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07363959
120TFEB_21752829_ChIP-Seq_HELA_Human1.05003838
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04408434
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03637975
123PIAS1_25552417_ChIP-Seq_VCAP_Human1.00807105
124TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00610115
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00532518
126* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99328500
127* TP53_22573176_ChIP-Seq_HFKS_Human0.99234400
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99135672
129STAT3_23295773_ChIP-Seq_U87_Human0.98717097
130CBP_20019798_ChIP-Seq_JUKART_Human0.98647370
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98647370
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98601166
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98015728
134KLF5_20875108_ChIP-Seq_MESCs_Mouse0.97280601
135* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.97055236
136* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96945471
137NANOG_21062744_ChIP-ChIP_HESCs_Human0.96847375
138* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96032911
139ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95900189
140* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94554091
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94462741
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93208945
143TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91021691
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90487412
145TCF4_22108803_ChIP-Seq_LS180_Human0.86545772
146TCF4_23295773_ChIP-Seq_U87_Human0.85922189
147SMAD4_21799915_ChIP-Seq_A2780_Human0.85701166
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85393667
149EZH2_27294783_Chip-Seq_NPCs_Mouse0.85374278
150PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83171272
151SMAD3_21741376_ChIP-Seq_EPCs_Human0.82251417

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis5.36176318
2MP0002139_abnormal_hepatobiliary_system4.80559348
3MP0005360_urolithiasis4.44163625
4MP0005365_abnormal_bile_salt3.74560882
5MP0005085_abnormal_gallbladder_physiolo3.66339221
6MP0003693_abnormal_embryo_hatching3.53769604
7MP0010094_abnormal_chromosome_stability3.21778446
8MP0004957_abnormal_blastocyst_morpholog3.16715481
9MP0003111_abnormal_nucleus_morphology3.01524315
10MP0003136_yellow_coat_color2.81725080
11MP0008057_abnormal_DNA_replication2.76628114
12MP0008875_abnormal_xenobiotic_pharmacok2.62303434
13MP0003077_abnormal_cell_cycle2.62168685
14MP0008058_abnormal_DNA_repair2.53189249
15MP0003186_abnormal_redox_activity2.39991331
16MP0003252_abnormal_bile_duct2.11773298
17MP0009697_abnormal_copulation2.04368941
18MP0002938_white_spotting2.02038093
19MP0005332_abnormal_amino_acid1.99494489
20MP0004133_heterotaxia1.96053498
21MP0003937_abnormal_limbs/digits/tail_de1.96006898
22MP0010329_abnormal_lipoprotein_level1.94236569
23MP0001730_embryonic_growth_arrest1.89960646
24MP0003123_paternal_imprinting1.89622996
25MP0010352_gastrointestinal_tract_polyps1.87101806
26MP0003890_abnormal_embryonic-extraembry1.85042370
27MP0008007_abnormal_cellular_replicative1.66655649
28MP0005670_abnormal_white_adipose1.62893342
29MP0006035_abnormal_mitochondrial_morpho1.61342222
30MP0008932_abnormal_embryonic_tissue1.61077944
31MP0002102_abnormal_ear_morphology1.59727819
32MP0002138_abnormal_hepatobiliary_system1.59367275
33MP0001764_abnormal_homeostasis1.58039206
34MP0004019_abnormal_vitamin_homeostasis1.57896358
35MP0002837_dystrophic_cardiac_calcinosis1.57416132
36MP0000350_abnormal_cell_proliferation1.56929721
37MP0003646_muscle_fatigue1.56465309
38MP0000569_abnormal_digit_pigmentation1.56329470
39MP0006036_abnormal_mitochondrial_physio1.53126255
40MP0003718_maternal_effect1.52153076
41MP0003705_abnormal_hypodermis_morpholog1.50192734
42MP0002736_abnormal_nociception_after1.48230536
43MP0004264_abnormal_extraembryonic_tissu1.48207737
44MP0005380_embryogenesis_phenotype1.47590817
45MP0001672_abnormal_embryogenesis/_devel1.47590817
46MP0010307_abnormal_tumor_latency1.43765381
47MP0005319_abnormal_enzyme/_coenzyme1.40633452
48MP0006072_abnormal_retinal_apoptosis1.37483920
49MP0005551_abnormal_eye_electrophysiolog1.35827288
50MP0001529_abnormal_vocalization1.34409156
51MP0009840_abnormal_foam_cell1.32583921
52MP0005266_abnormal_metabolism1.32363168
53MP0003984_embryonic_growth_retardation1.32148169
54MP0002088_abnormal_embryonic_growth/wei1.31065184
55MP0000427_abnormal_hair_cycle1.30541031
56MP0000609_abnormal_liver_physiology1.29881459
57MP0005174_abnormal_tail_pigmentation1.26542300
58MP0001697_abnormal_embryo_size1.25239114
59MP0000372_irregular_coat_pigmentation1.24657322
60MP0001286_abnormal_eye_development1.24449819
61MP0002234_abnormal_pharynx_morphology1.23968532
62MP0002086_abnormal_extraembryonic_tissu1.21745497
63MP0002080_prenatal_lethality1.17750351
64MP0001293_anophthalmia1.15493176
65MP0000631_abnormal_neuroendocrine_gland1.15357179
66MP0009046_muscle_twitch1.15162453
67MP0003567_abnormal_fetal_cardiomyocyte1.14410480
68MP0002697_abnormal_eye_size1.14057375
69MP0005083_abnormal_biliary_tract1.13996406
70MP0002233_abnormal_nose_morphology1.13838937
71MP0009053_abnormal_anal_canal1.13797145
72MP0003195_calcinosis1.12745060
73MP0000598_abnormal_liver_morphology1.12385544
74MP0004197_abnormal_fetal_growth/weight/1.11264858
75MP0000383_abnormal_hair_follicle1.09634922
76MP0001968_abnormal_touch/_nociception1.06339328
77MP0002751_abnormal_autonomic_nervous1.06255877
78MP0005253_abnormal_eye_physiology1.05807100
79MP0010030_abnormal_orbit_morphology1.05773086
80MP0002396_abnormal_hematopoietic_system1.03876685
81MP0003191_abnormal_cellular_cholesterol1.03611522
82MP0001666_abnormal_nutrient_absorption1.01697387
83MP0004147_increased_porphyrin_level1.01136138
84MP0002085_abnormal_embryonic_tissue1.00768064
85MP0000358_abnormal_cell_content/1.00652755
86MP0006292_abnormal_olfactory_placode1.00132161
87MP0003119_abnormal_digestive_system1.00058047
88MP0003755_abnormal_palate_morphology0.99961876
89MP0001929_abnormal_gametogenesis0.99869226
90MP0001984_abnormal_olfaction0.98942790
91MP0004043_abnormal_pH_regulation0.98746992
92MP0008789_abnormal_olfactory_epithelium0.98020367
93MP0003786_premature_aging0.97803108
94MP0002084_abnormal_developmental_patter0.96825900
95MP0003283_abnormal_digestive_organ0.96153633
96MP0000647_abnormal_sebaceous_gland0.95581195
97MP0009672_abnormal_birth_weight0.94566868
98MP0005171_absent_coat_pigmentation0.93118156
99MP0002019_abnormal_tumor_incidence0.93060085
100MP0009643_abnormal_urine_homeostasis0.92046534
101MP0003787_abnormal_imprinting0.91705208
102MP0002638_abnormal_pupillary_reflex0.91287523
103MP0005391_vision/eye_phenotype0.90395559
104MP0001485_abnormal_pinna_reflex0.89629490
105MP0000049_abnormal_middle_ear0.89497260
106MP0008872_abnormal_physiological_respon0.88774521
107MP0005376_homeostasis/metabolism_phenot0.87283533
108MP0003221_abnormal_cardiomyocyte_apopto0.86965786
109MP0000313_abnormal_cell_death0.86370706
110MP0000653_abnormal_sex_gland0.86282948
111MP0000371_diluted_coat_color0.86171048
112MP0002118_abnormal_lipid_homeostasis0.85784386
113MP0004142_abnormal_muscle_tone0.84918427
114MP0003880_abnormal_central_pattern0.80734930
115MP0001324_abnormal_eye_pigmentation0.80490372
116MP0008995_early_reproductive_senescence0.80420746
117MP0003698_abnormal_male_reproductive0.80174466
118MP0003861_abnormal_nervous_system0.80067991
119MP0002163_abnormal_gland_morphology0.80010268
120MP0000490_abnormal_crypts_of0.78335743
121MP0005499_abnormal_olfactory_system0.77907625
122MP0005394_taste/olfaction_phenotype0.77907625
123MP0005187_abnormal_penis_morphology0.77906634
124MP0003121_genomic_imprinting0.75449641
125MP0001299_abnormal_eye_distance/0.75340186
126MP0005084_abnormal_gallbladder_morpholo0.74833220
127MP0001346_abnormal_lacrimal_gland0.74387208
128MP0002095_abnormal_skin_pigmentation0.73849593
129MP0003938_abnormal_ear_development0.73800466
130MP0005195_abnormal_posterior_eye0.73495483
131MP0005584_abnormal_enzyme/coenzyme_acti0.69946264
132MP0001145_abnormal_male_reproductive0.67184418
133MP0005666_abnormal_adipose_tissue0.64785817
134MP0002653_abnormal_ependyma_morphology0.64688389
135MP0009763_increased_sensitivity_to0.62158945
136MP0001119_abnormal_female_reproductive0.61449531
137MP0005075_abnormal_melanosome_morpholog0.61116279
138MP0002111_abnormal_tail_morphology0.61114340
139MP0001756_abnormal_urination0.61038715
140MP0002210_abnormal_sex_determination0.60804668
141MP0001915_intracranial_hemorrhage0.60680866
142MP0002160_abnormal_reproductive_system0.60657052
143MP0003941_abnormal_skin_development0.60117619
144MP0005408_hypopigmentation0.59332799
145MP0000516_abnormal_urinary_system0.58146122
146MP0005367_renal/urinary_system_phenotyp0.58146122
147MP0008877_abnormal_DNA_methylation0.56806453
148MP0000858_altered_metastatic_potential0.56690069
149MP0002269_muscular_atrophy0.56670886
150MP0002075_abnormal_coat/hair_pigmentati0.55826319
151MP0005395_other_phenotype0.55612028
152MP0001661_extended_life_span0.55159330
153MP0002970_abnormal_white_adipose0.54793450
154MP0005389_reproductive_system_phenotype0.54494688
155MP0005384_cellular_phenotype0.54381935

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyrimidine metabolism (HP:0004353)4.98836263
2Hyperglycinemia (HP:0002154)4.89618522
3Hypobetalipoproteinemia (HP:0003563)4.59536955
4Abnormality of monocarboxylic acid metabolism (HP:0010996)4.58015770
5Hyperglycinuria (HP:0003108)4.24122560
6Intrahepatic cholestasis (HP:0001406)4.12203061
7Abnormality of serine family amino acid metabolism (HP:0010894)3.97102704
8Abnormality of glycine metabolism (HP:0010895)3.97102704
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.85033121
10Hyperammonemia (HP:0001987)3.62385338
11Pancreatic cysts (HP:0001737)3.52848093
12Birth length less than 3rd percentile (HP:0003561)3.49606294
13Prolonged partial thromboplastin time (HP:0003645)3.32139552
14Ependymoma (HP:0002888)3.31053622
15Pancreatic fibrosis (HP:0100732)3.29037144
16Abnormality of serum amino acid levels (HP:0003112)3.25514200
17Abnormality of sulfur amino acid metabolism (HP:0004339)3.19918957
18Chromsome breakage (HP:0040012)3.11273720
19Spastic diplegia (HP:0001264)3.07580234
20Chromosomal breakage induced by crosslinking agents (HP:0003221)3.03738407
21Delayed CNS myelination (HP:0002188)3.02721649
22Agnosia (HP:0010524)3.01567806
23Molar tooth sign on MRI (HP:0002419)2.97507056
24Abnormality of midbrain morphology (HP:0002418)2.97507056
25Abnormality of nucleobase metabolism (HP:0010932)2.96075298
26True hermaphroditism (HP:0010459)2.92744315
27Abnormality of methionine metabolism (HP:0010901)2.85578602
28Hypoglycemic coma (HP:0001325)2.82819200
29Hypolipoproteinemia (HP:0010981)2.82785960
30Abnormality of alanine metabolism (HP:0010916)2.82246850
31Hyperalaninemia (HP:0003348)2.82246850
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82246850
33Oral leukoplakia (HP:0002745)2.79832594
34Deep venous thrombosis (HP:0002625)2.79609450
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.77834758
36Nephronophthisis (HP:0000090)2.73229075
37Rhabdomyosarcoma (HP:0002859)2.71186185
38Xanthomatosis (HP:0000991)2.68548715
39Medulloblastoma (HP:0002885)2.66982998
40Joint hemorrhage (HP:0005261)2.65519889
41Abnormality of fatty-acid metabolism (HP:0004359)2.64590449
42Microvesicular hepatic steatosis (HP:0001414)2.64570911
43Breast hypoplasia (HP:0003187)2.64073055
44Colon cancer (HP:0003003)2.60252545
45Ketosis (HP:0001946)2.58962663
46Reticulocytopenia (HP:0001896)2.55690170
47Multiple enchondromatosis (HP:0005701)2.55600674
48Lethargy (HP:0001254)2.51945648
49Dicarboxylic aciduria (HP:0003215)2.51198733
50Abnormality of dicarboxylic acid metabolism (HP:0010995)2.51198733
51Abnormality of glutamine family amino acid metabolism (HP:0010902)2.46455839
52Medial flaring of the eyebrow (HP:0010747)2.42586045
53Abnormality of the labia minora (HP:0012880)2.42299573
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.41524055
55Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.41017031
56Hypochromic microcytic anemia (HP:0004840)2.40529134
57Impulsivity (HP:0100710)2.37585233
58Megaloblastic anemia (HP:0001889)2.35846343
59Increased serum pyruvate (HP:0003542)2.32635426
60Abnormality of glycolysis (HP:0004366)2.32635426
61Aplastic anemia (HP:0001915)2.31349946
62Abnormality of the renal medulla (HP:0100957)2.30145961
63Absent radius (HP:0003974)2.28820359
64Sloping forehead (HP:0000340)2.28301532
65Volvulus (HP:0002580)2.27262849
66Abnormality of the anterior horn cell (HP:0006802)2.26141733
67Degeneration of anterior horn cells (HP:0002398)2.26141733
68Cerebral edema (HP:0002181)2.25447835
69Triphalangeal thumb (HP:0001199)2.17822422
70Fat malabsorption (HP:0002630)2.17503712
71Abnormality of the renal cortex (HP:0011035)2.17421501
72Meckel diverticulum (HP:0002245)2.17243606
73Small intestinal stenosis (HP:0012848)2.16463306
74Duodenal stenosis (HP:0100867)2.16463306
75Increased CSF lactate (HP:0002490)2.16405657
76Aplasia/Hypoplasia of the tibia (HP:0005772)2.14900983
77Bifid tongue (HP:0010297)2.14287815
78Abnormality of chromosome stability (HP:0003220)2.14264421
79Hypoplasia of the pons (HP:0012110)2.13884117
80Sclerocornea (HP:0000647)2.13446857
81Complement deficiency (HP:0004431)2.12950048
82Abnormality of the intrinsic pathway (HP:0010989)2.12522121
83Metabolic acidosis (HP:0001942)2.11291284
84Chronic hepatic failure (HP:0100626)2.11191194
85Preaxial hand polydactyly (HP:0001177)2.11148253
86Abnormality of the ileum (HP:0001549)2.10424064
87Abnormality of the pons (HP:0007361)2.10184423
88Absent thumb (HP:0009777)2.08633577
89Gout (HP:0001997)2.08361870
90Acute necrotizing encephalopathy (HP:0006965)2.08277413
91Congenital primary aphakia (HP:0007707)2.07982973
92Aplasia involving forearm bones (HP:0009822)2.07885378
93Absent forearm bone (HP:0003953)2.07885378
94Abnormality of the carotid arteries (HP:0005344)2.07015960
95Epidermoid cyst (HP:0200040)2.06996601
96Nausea (HP:0002018)2.06356295
97Cystic liver disease (HP:0006706)2.05603166
98Abnormality of the duodenum (HP:0002246)2.05461337
99Ectopic kidney (HP:0000086)2.05456218
100Acute encephalopathy (HP:0006846)2.05320663
101Abnormality of the preputium (HP:0100587)2.04958835
102Abnormality of DNA repair (HP:0003254)2.04731125
103Hyperinsulinemic hypoglycemia (HP:0000825)2.04612031
104Abnormal biliary tract physiology (HP:0012439)2.04438685
105Bile duct proliferation (HP:0001408)2.04438685
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.01588794
107Gait imbalance (HP:0002141)2.00545271
108Small hand (HP:0200055)1.99553345
109Hyperlipoproteinemia (HP:0010980)1.98607939
110Intestinal atresia (HP:0011100)1.98587474
111Cortical dysplasia (HP:0002539)1.97346834
112Astrocytoma (HP:0009592)1.96652995
113Abnormality of the astrocytes (HP:0100707)1.96652995
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.96221077
115Pendular nystagmus (HP:0012043)1.95984720
116Ketoacidosis (HP:0001993)1.95136810
117Abnormality of purine metabolism (HP:0004352)1.94694816
118Neoplasm of the adrenal cortex (HP:0100641)1.94521348
119Genital tract atresia (HP:0001827)1.93794402
120Increased hepatocellular lipid droplets (HP:0006565)1.92976727
121Methylmalonic acidemia (HP:0002912)1.92955998
122Conjugated hyperbilirubinemia (HP:0002908)1.92616123
123Patellar aplasia (HP:0006443)1.92557625
124Dandy-Walker malformation (HP:0001305)1.92469879
125Vaginal atresia (HP:0000148)1.91642710
126Abnormal lung lobation (HP:0002101)1.91554134
127Supernumerary spleens (HP:0009799)1.90985575
128Neoplasm of striated muscle (HP:0009728)1.90842778
129Carpal bone hypoplasia (HP:0001498)1.90677130
130Clubbing of toes (HP:0100760)1.89816916
131Tubular atrophy (HP:0000092)1.89438493
132Opisthotonus (HP:0002179)1.89350574
133Nephrogenic diabetes insipidus (HP:0009806)1.89165503
134Mitochondrial inheritance (HP:0001427)1.87254183
135Glioma (HP:0009733)1.86767028
136Generalized aminoaciduria (HP:0002909)1.86155906
137Lipid accumulation in hepatocytes (HP:0006561)1.86077990
138Abnormal mitochondria in muscle tissue (HP:0008316)1.85728183
139Anencephaly (HP:0002323)1.84579525
140Rough bone trabeculation (HP:0100670)1.83171850
141Renal cortical cysts (HP:0000803)1.82803828
142Abnormality of abdominal situs (HP:0011620)1.82786052
143Abdominal situs inversus (HP:0003363)1.82786052
144Hypoglycemic seizures (HP:0002173)1.82165983
145Septo-optic dysplasia (HP:0100842)1.81912148
146Postaxial foot polydactyly (HP:0001830)1.80983923
147Anophthalmia (HP:0000528)1.80709349
148Ragged-red muscle fibers (HP:0003200)1.80400087
149Upper motor neuron abnormality (HP:0002127)1.79650402
150Vaginal fistula (HP:0004320)1.79511945
151Selective tooth agenesis (HP:0001592)1.79056588
152Poor coordination (HP:0002370)1.78663499
153Gaze-evoked nystagmus (HP:0000640)1.77844310
154Pancytopenia (HP:0001876)1.77812557
155Horseshoe kidney (HP:0000085)1.77546200
156Astigmatism (HP:0000483)1.75858666
157Cerebral hypomyelination (HP:0006808)1.74019896
158Increased serum lactate (HP:0002151)1.73490718
159Hyperbilirubinemia (HP:0002904)1.73393764
160Cerebellar dysplasia (HP:0007033)1.72991600
161Hepatocellular necrosis (HP:0001404)1.72904896
162Short thumb (HP:0009778)1.72763322
163Progressive macrocephaly (HP:0004481)1.72728740
164Delayed puberty (HP:0000823)1.71155333
165Aplasia/Hypoplasia of the patella (HP:0006498)1.70251118
166Congenital stationary night blindness (HP:0007642)1.69906514
167Stenosis of the external auditory canal (HP:0000402)1.67485098
168Duplicated collecting system (HP:0000081)1.67314628
169Nephroblastoma (Wilms tumor) (HP:0002667)1.65299495
170Hepatic necrosis (HP:0002605)1.64851788
171Type II lissencephaly (HP:0007260)1.62360203
172Gastrointestinal atresia (HP:0002589)1.61681332
173Methylmalonic aciduria (HP:0012120)1.61335622

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.26291454
2WEE13.87106582
3BCKDK3.47890296
4EIF2AK13.40009084
5BMPR1B3.26528301
6BUB13.20420007
7NEK13.10834588
8CDC73.09450528
9AKT32.42906601
10NEK22.36514945
11FLT32.34309332
12SRPK12.25949232
13TSSK62.21614715
14ACVR1B2.20469004
15NUAK12.18112509
16TTK1.99065939
17PLK11.98916984
18STK161.95994756
19TRIM281.93944094
20EIF2AK31.90330820
21BRSK21.89919317
22EPHA21.86719415
23RPS6KB21.85231150
24WNK41.83170720
25CDK121.76980286
26VRK11.70091770
27CDK71.68957662
28TNIK1.68206700
29TLK11.66145906
30ZAK1.63364225
31TESK21.59709648
32PLK31.59045350
33PLK41.56778429
34MAP3K41.56223103
35ATR1.51413848
36TAF11.50975249
37CASK1.48518027
38BCR1.47365576
39CDK41.41952599
40PASK1.40259924
41SCYL21.38311372
42CHEK21.37710436
43INSRR1.37089546
44DYRK31.34600631
45AURKB1.34101060
46PKN21.33871059
47STK391.32725778
48VRK21.27897060
49AURKA1.26690882
50GRK11.25722022
51NME21.23709782
52TGFBR11.23689799
53NME11.19547063
54PDK41.17865459
55PDK31.17865459
56ADRBK21.16551657
57MAP3K81.11700377
58PLK21.11366544
59PBK1.09774188
60PNCK1.09258285
61RPS6KA41.03112413
62MAPKAPK31.02742247
63CHEK11.02731745
64OXSR10.99606671
65MAP4K20.98650040
66CDK60.96826663
67BRAF0.95693406
68ERBB40.95638254
69MAP3K100.93998466
70MST40.91787821
71STK38L0.91197289
72MAP3K110.89061541
73BRSK10.89046201
74BRD40.87804714
75MAP2K70.85627211
76CCNB10.84026198
77PDK20.82905888
78FGFR20.82718812
79STK30.82562045
80TAOK20.79944190
81EIF2AK20.79694642
82YES10.78638940
83CSNK1A1L0.77509348
84CSNK2A20.76973812
85MKNK10.76930483
86PAK40.76514147
87CDK80.75761112
88NEK90.75693231
89ATM0.75161030
90STK100.75084626
91KDR0.72750852
92CDK20.71650735
93MAPK110.70536501
94DAPK10.70366624
95CSNK2A10.69376608
96CSNK1G20.67556908
97STK40.66668987
98CSNK1G30.66073796
99PIM20.64472297
100EPHA40.60947464
101MAPK130.58557225
102PIM10.57309074
103LATS20.56787255
104IRAK30.56757291
105CAMK1G0.56516827
106AKT20.56299128
107PRKCG0.54984871
108PRKCI0.54373803
109MELK0.49881223
110DYRK20.49514166
111PIK3CA0.49202121
112ADRBK10.48716762
113MKNK20.48290980
114CSNK1E0.47163527
115PAK30.46339929
116CAMK1D0.45720672
117MTOR0.45682072
118CDK10.45510981
119PRKCE0.43609946
120MARK30.43532839
121RPS6KA50.43025238
122ERBB30.41258321
123MATK0.40398399
124MAP2K30.39685038
125PINK10.36873868
126LATS10.36478358
127PRKDC0.36008320
128FGFR10.35552753
129CSNK1A10.34016518
130RPS6KB10.32893910
131WNK30.32484652
132MAP3K50.32289983
133MET0.32241048
134ALK0.31809520
135CSNK1D0.31303983
136GRK60.31117075
137MUSK0.31038245
138PAK10.30529621
139MAP2K60.29274139
140TAOK30.27740223
141CSNK1G10.26277811
142EEF2K0.23008609

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.95413842
2Mismatch repair_Homo sapiens_hsa034302.94324442
3One carbon pool by folate_Homo sapiens_hsa006702.83192380
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53035145
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.49529150
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47093174
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.40234239
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.35133296
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.31093057
10Proteasome_Homo sapiens_hsa030502.16590202
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08338612
12Protein export_Homo sapiens_hsa030602.00128849
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.90960844
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.90828280
15RNA transport_Homo sapiens_hsa030131.89030707
16Biosynthesis of amino acids_Homo sapiens_hsa012301.86995464
17Nitrogen metabolism_Homo sapiens_hsa009101.86728374
18Drug metabolism - other enzymes_Homo sapiens_hsa009831.85003761
19Base excision repair_Homo sapiens_hsa034101.83870517
20Selenocompound metabolism_Homo sapiens_hsa004501.81317451
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81301791
22Oxidative phosphorylation_Homo sapiens_hsa001901.80562922
23Arginine biosynthesis_Homo sapiens_hsa002201.79936291
24Folate biosynthesis_Homo sapiens_hsa007901.79607953
25RNA polymerase_Homo sapiens_hsa030201.78092620
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.75772564
27Spliceosome_Homo sapiens_hsa030401.74100743
28Tryptophan metabolism_Homo sapiens_hsa003801.68522864
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.68066307
30Carbon metabolism_Homo sapiens_hsa012001.67446187
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65657002
32Pyrimidine metabolism_Homo sapiens_hsa002401.64868124
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58680416
34Nucleotide excision repair_Homo sapiens_hsa034201.58657185
35Fatty acid degradation_Homo sapiens_hsa000711.57456478
36Parkinsons disease_Homo sapiens_hsa050121.56470469
37Propanoate metabolism_Homo sapiens_hsa006401.54736857
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48241870
39Peroxisome_Homo sapiens_hsa041461.48109750
40Homologous recombination_Homo sapiens_hsa034401.47859607
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.45510392
42Ribosome_Homo sapiens_hsa030101.43996932
43Huntingtons disease_Homo sapiens_hsa050161.35093876
44Pyruvate metabolism_Homo sapiens_hsa006201.32436393
45Complement and coagulation cascades_Homo sapiens_hsa046101.28818223
46Sulfur relay system_Homo sapiens_hsa041221.25635902
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.24673995
48Cell cycle_Homo sapiens_hsa041101.23690584
49beta-Alanine metabolism_Homo sapiens_hsa004101.23654751
50Phenylalanine metabolism_Homo sapiens_hsa003601.17107650
51Fanconi anemia pathway_Homo sapiens_hsa034601.16658484
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12027139
53Pentose phosphate pathway_Homo sapiens_hsa000301.11499449
54Phototransduction_Homo sapiens_hsa047441.10660135
55Tyrosine metabolism_Homo sapiens_hsa003501.07373614
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04179932
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03992546
58Butanoate metabolism_Homo sapiens_hsa006501.03421686
59Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03002901
60Histidine metabolism_Homo sapiens_hsa003401.02157479
61Fructose and mannose metabolism_Homo sapiens_hsa000510.99192984
62Glutathione metabolism_Homo sapiens_hsa004800.97028087
63Chemical carcinogenesis_Homo sapiens_hsa052040.95974311
64Non-homologous end-joining_Homo sapiens_hsa034500.95306394
65Alzheimers disease_Homo sapiens_hsa050100.92360119
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91795444
67Fatty acid metabolism_Homo sapiens_hsa012120.89209599
68Nicotine addiction_Homo sapiens_hsa050330.87289766
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85861308
70RNA degradation_Homo sapiens_hsa030180.85069072
71Arginine and proline metabolism_Homo sapiens_hsa003300.84785450
72Vitamin B6 metabolism_Homo sapiens_hsa007500.80890126
73Retinol metabolism_Homo sapiens_hsa008300.80145179
74Vitamin digestion and absorption_Homo sapiens_hsa049770.79586924
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.78817442
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78773354
77Linoleic acid metabolism_Homo sapiens_hsa005910.77191792
78PPAR signaling pathway_Homo sapiens_hsa033200.77063042
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76209701
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73121968
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72457234
82Starch and sucrose metabolism_Homo sapiens_hsa005000.70530829
83Basal cell carcinoma_Homo sapiens_hsa052170.70387179
84Purine metabolism_Homo sapiens_hsa002300.69734549
85mRNA surveillance pathway_Homo sapiens_hsa030150.68855692
86p53 signaling pathway_Homo sapiens_hsa041150.68567155
87Systemic lupus erythematosus_Homo sapiens_hsa053220.68492855
88Taste transduction_Homo sapiens_hsa047420.68429233
89alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68018698
90Lysine degradation_Homo sapiens_hsa003100.66226044
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65521770
92Galactose metabolism_Homo sapiens_hsa000520.65254952
93Ether lipid metabolism_Homo sapiens_hsa005650.63464612
94Hedgehog signaling pathway_Homo sapiens_hsa043400.62162899
95Basal transcription factors_Homo sapiens_hsa030220.60627140
96TGF-beta signaling pathway_Homo sapiens_hsa043500.60369359
97Oocyte meiosis_Homo sapiens_hsa041140.60336827
98Fat digestion and absorption_Homo sapiens_hsa049750.59543798
99Hippo signaling pathway_Homo sapiens_hsa043900.59448312
100Metabolic pathways_Homo sapiens_hsa011000.56630921
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55750459
102Cardiac muscle contraction_Homo sapiens_hsa042600.54982265
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.53203548
104N-Glycan biosynthesis_Homo sapiens_hsa005100.51840800
105Staphylococcus aureus infection_Homo sapiens_hsa051500.51718748
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51355386
107Caffeine metabolism_Homo sapiens_hsa002320.50165172
108Epstein-Barr virus infection_Homo sapiens_hsa051690.49265062
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46494901
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44661062
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43979983
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43847905
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42578571
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42043819
115Thyroid cancer_Homo sapiens_hsa052160.39236697
116Bile secretion_Homo sapiens_hsa049760.33463546
117Sulfur metabolism_Homo sapiens_hsa009200.33146955
118ABC transporters_Homo sapiens_hsa020100.31897765
119Legionellosis_Homo sapiens_hsa051340.30854479
120Viral carcinogenesis_Homo sapiens_hsa052030.26240866
121Glycerolipid metabolism_Homo sapiens_hsa005610.22454712
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22049930
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.20428465
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.18905249
125Herpes simplex infection_Homo sapiens_hsa051680.17585433
126Steroid biosynthesis_Homo sapiens_hsa001000.15738892
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.15579185
128Fatty acid elongation_Homo sapiens_hsa000620.15028016

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