FBXO24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.59220531
2axonemal dynein complex assembly (GO:0070286)9.56135146
3reproduction (GO:0000003)9.28481591
4spermatid development (GO:0007286)9.14626721
5epithelial cilium movement (GO:0003351)8.98740983
6regulation of cilium movement (GO:0003352)8.08624632
7cilium movement (GO:0003341)7.23778517
8single fertilization (GO:0007338)7.18416443
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.98857832
10sperm capacitation (GO:0048240)6.98339997
11male meiosis (GO:0007140)6.56744954
12piRNA metabolic process (GO:0034587)6.56703077
13synaptonemal complex organization (GO:0070193)6.47645647
14organic cation transport (GO:0015695)6.38358873
15synaptonemal complex assembly (GO:0007130)6.33526481
16spermatogenesis (GO:0007283)6.32336012
17male gamete generation (GO:0048232)6.30062716
18fertilization (GO:0009566)6.05801227
19microtubule depolymerization (GO:0007019)6.05307636
20negative regulation of inclusion body assembly (GO:0090084)6.01395636
21gamete generation (GO:0007276)5.78882155
22cellular process involved in reproduction in multicellular organism (GO:0022412)5.35737683
23response to pheromone (GO:0019236)5.33099544
24regulation of inclusion body assembly (GO:0090083)5.19635155
25germ cell development (GO:0007281)5.19480300
26calcium ion-dependent exocytosis (GO:0017156)5.12546553
27chromosome condensation (GO:0030261)5.02099161
28behavioral response to nicotine (GO:0035095)4.99163289
29cell recognition (GO:0008037)4.95224172
30DNA packaging (GO:0006323)4.84512003
31ventricular system development (GO:0021591)4.78854128
32regulation of microtubule-based movement (GO:0060632)4.69073939
33seminiferous tubule development (GO:0072520)4.64666284
34male meiosis I (GO:0007141)4.59338231
35microtubule severing (GO:0051013)4.55451111
36multicellular organismal reproductive process (GO:0048609)4.54922153
37spermatid nucleus differentiation (GO:0007289)4.47717703
38chromosome organization involved in meiosis (GO:0070192)4.29215111
39cellular ketone body metabolic process (GO:0046950)4.24719509
40sequestering of actin monomers (GO:0042989)4.15840341
41DNA methylation involved in gamete generation (GO:0043046)4.15833615
42glycerol ether metabolic process (GO:0006662)4.14125152
43meiotic nuclear division (GO:0007126)4.11279339
44chaperone-mediated protein complex assembly (GO:0051131)3.98066207
45left/right pattern formation (GO:0060972)3.97862126
46indolalkylamine metabolic process (GO:0006586)3.92175948
47ketone body metabolic process (GO:1902224)3.91616961
48indole-containing compound catabolic process (GO:0042436)3.89538986
49indolalkylamine catabolic process (GO:0046218)3.89538986
50tryptophan catabolic process (GO:0006569)3.89538986
51establishment of protein localization to Golgi (GO:0072600)3.87786913
52monoubiquitinated protein deubiquitination (GO:0035520)3.81918169
53ether metabolic process (GO:0018904)3.80025184
54multicellular organismal development (GO:0007275)3.68761774
55meiosis I (GO:0007127)3.68304342
56protein targeting to Golgi (GO:0000042)3.53227326
57genitalia morphogenesis (GO:0035112)3.44169960
58carnitine transport (GO:0015879)3.35452611
59amino-acid betaine transport (GO:0015838)3.35452611
60regulation of spindle checkpoint (GO:0090231)3.33167832
61RNA localization (GO:0006403)3.32916515
62single strand break repair (GO:0000012)3.32715768
63positive regulation of macrophage activation (GO:0043032)3.30069169
64regulation of meiosis I (GO:0060631)3.29413969
65detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27131960
66phosphatidylethanolamine metabolic process (GO:0046337)3.26910905
67meiotic cell cycle (GO:0051321)3.25960154
68DNA deamination (GO:0045006)3.25491642
69phosphatidylethanolamine biosynthetic process (GO:0006646)3.22992244
70protein polyglutamylation (GO:0018095)3.22964902
71carnitine transmembrane transport (GO:1902603)3.20278857
72tryptophan metabolic process (GO:0006568)3.19325118
73fucose catabolic process (GO:0019317)3.16521517
74L-fucose metabolic process (GO:0042354)3.16521517
75L-fucose catabolic process (GO:0042355)3.16521517
76RNA destabilization (GO:0050779)3.15882881
77interferon-gamma secretion (GO:0072643)3.15405749
78photoreceptor cell maintenance (GO:0045494)3.14275522
79retrograde transport, vesicle recycling within Golgi (GO:0000301)3.13119431
80nucleus organization (GO:0006997)3.11132415
81sexual reproduction (GO:0019953)3.10275604
82detection of light stimulus involved in visual perception (GO:0050908)3.09070665
83detection of light stimulus involved in sensory perception (GO:0050962)3.09070665
84primary amino compound metabolic process (GO:1901160)3.08432546
85indole-containing compound metabolic process (GO:0042430)3.05714739
86DNA double-strand break processing (GO:0000729)3.05586904
87protein localization to cilium (GO:0061512)3.04418270
88neuronal action potential (GO:0019228)3.00847395
89mitotic sister chromatid cohesion (GO:0007064)2.92625619
90cellular biogenic amine catabolic process (GO:0042402)2.92116030
91amine catabolic process (GO:0009310)2.92116030
92microtubule polymerization or depolymerization (GO:0031109)2.89064241
93protein localization to Golgi apparatus (GO:0034067)2.86220490
94nuclear pore complex assembly (GO:0051292)2.84201124
95behavioral response to ethanol (GO:0048149)2.81738991
96sulfation (GO:0051923)2.81170088
97reflex (GO:0060004)2.80307521
98centriole assembly (GO:0098534)2.80059880
99serotonin metabolic process (GO:0042428)2.79574062
100kynurenine metabolic process (GO:0070189)2.78188859
101membrane depolarization during action potential (GO:0086010)2.76819052
102protein-DNA complex disassembly (GO:0032986)2.76061210
103nucleosome disassembly (GO:0006337)2.76061210
104detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.75907740
105protein refolding (GO:0042026)2.75624523
106rRNA methylation (GO:0031167)2.74390320
107somite rostral/caudal axis specification (GO:0032525)2.74036525
108gene silencing by RNA (GO:0031047)2.73998810
109neural tube formation (GO:0001841)2.73567970
110nephron epithelium morphogenesis (GO:0072088)2.72702388
111nephron tubule morphogenesis (GO:0072078)2.72702388
112axoneme assembly (GO:0035082)2.71550384
113NAD biosynthetic process (GO:0009435)2.71523245
114G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.70886996
115negative regulation of organelle assembly (GO:1902116)2.69436667
116regulation of cilium assembly (GO:1902017)2.69289229
117protein K11-linked deubiquitination (GO:0035871)2.67530440
118cilium organization (GO:0044782)2.67265455
119response to acidic pH (GO:0010447)2.64867211
120polyol catabolic process (GO:0046174)2.61436559
121glycolytic process (GO:0006096)2.60894044
122meiotic cell cycle process (GO:1903046)2.60874426
123cilium morphogenesis (GO:0060271)2.59446333
124mannosylation (GO:0097502)2.57218677
125sphingoid metabolic process (GO:0046519)2.56959206
126aromatic amino acid family catabolic process (GO:0009074)2.56940740
127coenzyme catabolic process (GO:0009109)2.55182882
128left/right axis specification (GO:0070986)2.54624060
129reciprocal meiotic recombination (GO:0007131)2.54556223
130reciprocal DNA recombination (GO:0035825)2.54556223
131microtubule-based movement (GO:0007018)2.54388239
132regulation of phosphoprotein phosphatase activity (GO:0043666)2.54115482
133cilium assembly (GO:0042384)2.53566325
134regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53537582
135centriole replication (GO:0007099)2.53230168
136cellular component assembly involved in morphogenesis (GO:0010927)2.51774255
137synapsis (GO:0007129)2.50152821
138cellular hyperosmotic response (GO:0071474)2.46211601
139gene silencing (GO:0016458)2.44211344
140lactate metabolic process (GO:0006089)2.43435956
141regulation of cytokine production involved in inflammatory response (GO:1900015)2.42900961
142cell wall macromolecule catabolic process (GO:0016998)14.6238273
143cell wall macromolecule metabolic process (GO:0044036)14.6238273
144fusion of sperm to egg plasma membrane (GO:0007342)14.2896333
145sperm motility (GO:0030317)12.2380023
146sperm-egg recognition (GO:0035036)11.7272796
147acrosome reaction (GO:0007340)11.6419686
148acrosome assembly (GO:0001675)11.2149794
149multicellular organism reproduction (GO:0032504)11.0511187
150plasma membrane fusion (GO:0045026)10.8349926
151cell-cell recognition (GO:0009988)10.5430760
152binding of sperm to zona pellucida (GO:0007339)10.3283730
153cilium or flagellum-dependent cell motility (GO:0001539)10.0461590

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human4.00942792
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50917140
3GBX2_23144817_ChIP-Seq_PC3_Human3.09914978
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.01321312
5IGF1R_20145208_ChIP-Seq_DFB_Human2.84417681
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79537692
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.67009806
8CTBP2_25329375_ChIP-Seq_LNCAP_Human2.66589427
9* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.59966865
10EZH2_22144423_ChIP-Seq_EOC_Human2.44062466
11FUS_26573619_Chip-Seq_HEK293_Human2.37722044
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36460408
13CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27334192
14ER_23166858_ChIP-Seq_MCF-7_Human2.14424628
15P300_19829295_ChIP-Seq_ESCs_Human2.13944995
16GATA1_26923725_Chip-Seq_HPCs_Mouse2.12173696
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08712529
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.0442973
19ZNF274_21170338_ChIP-Seq_K562_Hela1.91128304
20FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90167837
21TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89745341
22POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.89745341
23ELK4_26923725_Chip-Seq_MESODERM_Mouse1.88849510
24UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.83982670
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83448468
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.83202000
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.82166211
28AR_21572438_ChIP-Seq_LNCaP_Human1.79214071
29SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.76475052
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75231783
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.74290564
32TAF15_26573619_Chip-Seq_HEK293_Human1.71843530
33AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71524180
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70665678
35SMAD4_21799915_ChIP-Seq_A2780_Human1.69588698
36STAT3_23295773_ChIP-Seq_U87_Human1.69216906
37EWS_26573619_Chip-Seq_HEK293_Human1.67275975
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66922716
39TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.65811332
40AR_25329375_ChIP-Seq_VCAP_Human1.64934755
41STAT1_17558387_ChIP-Seq_HELA_Human1.63779712
42GATA3_21867929_ChIP-Seq_CD8_Mouse1.61947466
43* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61061399
44GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.58126916
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57082663
46ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.56184533
47FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.56070495
48SMAD3_21741376_ChIP-Seq_EPCs_Human1.55740907
49SOX2_22085726_ChIP-Seq_NPCs_Mouse1.55585887
50KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53913165
51ELF1_20517297_ChIP-Seq_JURKAT_Human1.51843367
52BCAT_22108803_ChIP-Seq_LS180_Human1.51340424
53TCF4_23295773_ChIP-Seq_U87_Human1.50931782
54NANOG_19829295_ChIP-Seq_ESCs_Human1.50462467
55SOX2_19829295_ChIP-Seq_ESCs_Human1.50462467
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49304899
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.48079353
58LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.45897773
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45211658
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.44988578
61NR3C1_21868756_ChIP-Seq_MCF10A_Human1.43562300
62SMAD4_21741376_ChIP-Seq_EPCs_Human1.43026234
63RUNX2_22187159_ChIP-Seq_PCA_Human1.39472489
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.38465954
65P53_21459846_ChIP-Seq_SAOS-2_Human1.37747079
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.37642114
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.34736867
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34620775
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33481123
70TCF4_22108803_ChIP-Seq_LS180_Human1.32929147
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32594206
72SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30313266
73VDR_22108803_ChIP-Seq_LS180_Human1.29555912
74BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29181748
75TET1_21451524_ChIP-Seq_MESCs_Mouse1.27792354
76TP53_22573176_ChIP-Seq_HFKS_Human1.27501575
77SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27152025
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.27055219
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26616656
80RARA_24833708_ChIP-Seq_LIVER_Mouse1.25769110
81CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25374136
82KAP1_22055183_ChIP-Seq_ESCs_Mouse1.24923451
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24076720
84FOXA1_25329375_ChIP-Seq_VCAP_Human1.23302788
85FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23302788
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23042766
87NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22455746
88KDM2B_26808549_Chip-Seq_REH_Human1.21764880
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21034126
90ARNT_22903824_ChIP-Seq_MCF-7_Human1.20959613
91FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20549241
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20503590
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.20061975
94SALL1_21062744_ChIP-ChIP_HESCs_Human1.19637358
95EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.18818256
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.18734581
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18605303
98GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17464074
99RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17174598
100HOXB7_26014856_ChIP-Seq_BT474_Human1.16963403
101IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16849697
102CBP_20019798_ChIP-Seq_JUKART_Human1.16849697
103AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14246860
104* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13900413
105FLI1_21867929_ChIP-Seq_TH2_Mouse1.13495809
106EZH2_27294783_Chip-Seq_NPCs_Mouse1.13248437
107MYC_19829295_ChIP-Seq_ESCs_Human1.12821689
108NCOR_22424771_ChIP-Seq_293T_Human1.12415587
109LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11698861
110SRY_22984422_ChIP-ChIP_TESTIS_Rat1.11059009
111RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10800307
112ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10709362
113PHF8_20622854_ChIP-Seq_HELA_Human1.10634939
114PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10611594
115GATA3_21867929_ChIP-Seq_TH1_Mouse1.10317239
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10299050
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.10093358
118GATA1_19941827_ChIP-Seq_MEL86_Mouse1.09722771
119BCOR_27268052_Chip-Seq_Bcells_Human1.09072171
120LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08964525
121SPI1_26923725_Chip-Seq_HPCs_Mouse1.08930358
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08483151
123CDX2_22108803_ChIP-Seq_LS180_Human1.07926566
124GF1_26923725_Chip-Seq_HPCs_Mouse1.07786402
125FLI1_21867929_ChIP-Seq_CD8_Mouse1.07705984
126RNF2_27304074_Chip-Seq_NSC_Mouse1.07123662
127ERG_20517297_ChIP-Seq_VCAP_Human1.06340047
128CTCF_20526341_ChIP-Seq_ESCs_Human1.06074942
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06033253
130ERA_21632823_ChIP-Seq_H3396_Human1.06021687
131NANOG_18555785_Chip-Seq_ESCs_Mouse1.05674118
132RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05479281
133MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04649728
134SMAD3_21741376_ChIP-Seq_ESCs_Human1.04132310
135AR_20517297_ChIP-Seq_VCAP_Human1.03653327
136MYC_27129775_Chip-Seq_CORNEA_Mouse1.03327080
137OCT4_20526341_ChIP-Seq_ESCs_Human1.03325041
138KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.03145677
139RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02680356
140IRF1_19129219_ChIP-ChIP_H3396_Human1.02259110
141TBL1_22424771_ChIP-Seq_293T_Human1.01555844
142NOTCH1_21737748_ChIP-Seq_TLL_Human1.00539290
143TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00086914
144OCT1_27270436_Chip-Seq_PROSTATE_Human0.98703153
145* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.98106763
146CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.97667852
147BCL6_27268052_Chip-Seq_Bcells_Human0.97034071
148OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96778049
149CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96638021
150RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96264621
151SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96234641
152CTCF_26484167_Chip-Seq_Bcells_Mouse0.95779770
153SOX2_21211035_ChIP-Seq_LN229_Human0.95409870
154EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95114455
155DROSHA_22980978_ChIP-Seq_HELA_Human0.95063196
156* ESET_19884257_ChIP-Seq_ESCs_Mouse0.94686343
157TCF7_22412390_ChIP-Seq_EML_Mouse0.93599145
158CBX2_27304074_Chip-Seq_ESCs_Mouse0.92665716
159PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92338164
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91460328
161RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91043949
162SOX11_22085726_ChIP-Seq_ESNs_Mouse0.90962867
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.88352495
164SPI1_20517297_ChIP-Seq_HL60_Human0.87638534
165REST_21632747_ChIP-Seq_MESCs_Mouse0.87634439
166NFE2_27457419_Chip-Seq_LIVER_Mouse0.85438746
167PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84975255
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.84895657
169E2F1_20622854_ChIP-Seq_HELA_Human0.83989134
170NANOG_20526341_ChIP-Seq_ESCs_Human0.83984335
171SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83121419
172GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.83096096
173ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82858626
174PCGF2_27294783_Chip-Seq_NPCs_Mouse0.82189175
175FOXM1_23109430_ChIP-Seq_U2OS_Human0.82005761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.71029598
2MP0001929_abnormal_gametogenesis5.26638021
3MP0008877_abnormal_DNA_methylation3.60629062
4MP0002210_abnormal_sex_determination3.23146228
5MP0000569_abnormal_digit_pigmentation3.19249664
6MP0005670_abnormal_white_adipose3.09029386
7MP0002161_abnormal_fertility/fecundity3.08217762
8MP0002837_dystrophic_cardiac_calcinosis3.06242129
9MP0001145_abnormal_male_reproductive2.79714008
10MP0005551_abnormal_eye_electrophysiolog2.70689824
11MP0002653_abnormal_ependyma_morphology2.68732797
12MP0003136_yellow_coat_color2.59532201
13MP0001968_abnormal_touch/_nociception2.53255359
14MP0000653_abnormal_sex_gland2.40203869
15MP0003195_calcinosis2.33968603
16MP0006072_abnormal_retinal_apoptosis2.00677400
17MP0005410_abnormal_fertilization15.7996624
18MP0004233_abnormal_muscle_weight1.95178227
19MP0002938_white_spotting1.88256873
20MP0002736_abnormal_nociception_after1.84426838
21MP0002160_abnormal_reproductive_system1.81778543
22MP0001486_abnormal_startle_reflex1.78748024
23MP0009745_abnormal_behavioral_response1.74574520
24MP0005646_abnormal_pituitary_gland1.74069599
25MP0001485_abnormal_pinna_reflex1.70211117
26MP0001501_abnormal_sleep_pattern1.69762982
27MP0003646_muscle_fatigue1.64010888
28MP0000372_irregular_coat_pigmentation1.58539377
29MP0002735_abnormal_chemical_nociception1.57943968
30MP0002272_abnormal_nervous_system1.56340791
31MP0005171_absent_coat_pigmentation1.54231493
32MP0008872_abnormal_physiological_respon1.52419008
33MP0002138_abnormal_hepatobiliary_system1.51668621
34MP0003045_fibrosis1.45189678
35MP0010386_abnormal_urinary_bladder1.43519483
36MP0000427_abnormal_hair_cycle1.38532097
37MP0004742_abnormal_vestibular_system1.37244665
38MP0004885_abnormal_endolymph1.32537234
39MP0002572_abnormal_emotion/affect_behav1.31479829
40MP0001986_abnormal_taste_sensitivity1.31354786
41MP0006276_abnormal_autonomic_nervous1.28393238
42MP0003718_maternal_effect1.27300827
43MP0003880_abnormal_central_pattern1.25627266
44MP0005645_abnormal_hypothalamus_physiol1.23806750
45MP0002067_abnormal_sensory_capabilities1.23194199
46MP0005623_abnormal_meninges_morphology1.23152790
47MP0002733_abnormal_thermal_nociception1.20033409
48MP0001970_abnormal_pain_threshold1.18655467
49MP0004043_abnormal_pH_regulation1.17339809
50MP0003890_abnormal_embryonic-extraembry1.14620260
51MP0002876_abnormal_thyroid_physiology1.13803207
52MP0004142_abnormal_muscle_tone1.13140623
53MP0006292_abnormal_olfactory_placode1.11752682
54MP0002557_abnormal_social/conspecific_i1.10112889
55MP0002064_seizures1.07817303
56MP0009278_abnormal_bone_marrow1.05973547
57MP0005085_abnormal_gallbladder_physiolo1.04443375
58MP0002638_abnormal_pupillary_reflex1.04375629
59MP0004133_heterotaxia1.02552106
60MP0009697_abnormal_copulation1.01681938
61MP0005084_abnormal_gallbladder_morpholo1.01203119
62MP0005075_abnormal_melanosome_morpholog1.01198947
63MP0002234_abnormal_pharynx_morphology1.00411939
64MP0000631_abnormal_neuroendocrine_gland1.00095429
65MP0002229_neurodegeneration0.98204164
66MP0003137_abnormal_impulse_conducting0.97963830
67MP0010094_abnormal_chromosome_stability0.95316013
68MP0003635_abnormal_synaptic_transmissio0.94943767
69MP0000026_abnormal_inner_ear0.94180803
70MP0001963_abnormal_hearing_physiology0.93225812
71MP0008875_abnormal_xenobiotic_pharmacok0.92001849
72MP0002282_abnormal_trachea_morphology0.91935852
73MP0001765_abnormal_ion_homeostasis0.91072097
74MP0005195_abnormal_posterior_eye0.90694004
75MP0003879_abnormal_hair_cell0.90431918
76MP0008058_abnormal_DNA_repair0.90422029
77MP0005379_endocrine/exocrine_gland_phen0.89217133
78MP0002095_abnormal_skin_pigmentation0.88869093
79MP0003115_abnormal_respiratory_system0.88784519
80MP0005647_abnormal_sex_gland0.88493627
81MP0005397_hematopoietic_system_phenotyp0.88308615
82MP0001545_abnormal_hematopoietic_system0.88308615
83MP0005389_reproductive_system_phenotype0.87056573
84MP0001905_abnormal_dopamine_level0.86247896
85MP0004924_abnormal_behavior0.83843177
86MP0005386_behavior/neurological_phenoty0.83843177
87MP0008961_abnormal_basal_metabolism0.83789760
88MP0004808_abnormal_hematopoietic_stem0.83172888
89MP0008007_abnormal_cellular_replicative0.82914071
90MP0005395_other_phenotype0.81757602
91MP0000230_abnormal_systemic_arterial0.81302860
92MP0000015_abnormal_ear_pigmentation0.81035405
93MP0002752_abnormal_somatic_nervous0.79694135
94MP0003111_abnormal_nucleus_morphology0.78941895
95MP0001919_abnormal_reproductive_system0.78834112
96MP0004484_altered_response_of0.78638398
97MP0005365_abnormal_bile_salt0.78207883
98MP0003787_abnormal_imprinting0.75815665
99MP0005310_abnormal_salivary_gland0.75735253
100MP0004085_abnormal_heartbeat0.75100192
101MP0008995_early_reproductive_senescence0.74785490
102MP0005167_abnormal_blood-brain_barrier0.74749384
103MP0005666_abnormal_adipose_tissue0.74738952
104MP0001984_abnormal_olfaction0.73653269
105MP0002168_other_aberrant_phenotype0.73579681
106MP0001764_abnormal_homeostasis0.72476925
107MP0003633_abnormal_nervous_system0.72329292
108MP0002405_respiratory_system_inflammati0.64096431
109MP0002928_abnormal_bile_duct0.63933552
110MP0009115_abnormal_fat_cell0.63149476
111MP0000358_abnormal_cell_content/0.62665394
112MP0002269_muscular_atrophy0.61630177
113MP0010307_abnormal_tumor_latency0.59822958
114MP0001661_extended_life_span0.57528085
115MP0000703_abnormal_thymus_morphology0.54213365
116MP0003077_abnormal_cell_cycle0.53848039
117MP0005377_hearing/vestibular/ear_phenot0.52852046
118MP0003878_abnormal_ear_physiology0.52852046
119MP0001324_abnormal_eye_pigmentation0.50665497
120MP0002398_abnormal_bone_marrow0.50208849
121MP0003699_abnormal_female_reproductive0.49485743
122MP0000313_abnormal_cell_death0.48716089
123MP0001730_embryonic_growth_arrest0.48447826
124MP0001293_anophthalmia0.45830032
125MP0008057_abnormal_DNA_replication0.44167104
126MP0001873_stomach_inflammation0.43462474
127MP0000685_abnormal_immune_system0.43373962
128MP0003279_aneurysm0.42109502
129MP0002102_abnormal_ear_morphology0.42022271
130MP0002084_abnormal_developmental_patter0.41938850
131MP0009046_muscle_twitch0.41489953
132MP0006036_abnormal_mitochondrial_physio0.41117463
133MP0003763_abnormal_thymus_physiology0.40906224
134MP0005636_abnormal_mineral_homeostasis0.40720598
135MP0001800_abnormal_humoral_immune0.38912654
136MP0002132_abnormal_respiratory_system0.37657933
137MP0005375_adipose_tissue_phenotype0.37568010
138MP0000689_abnormal_spleen_morphology0.37498495
139MP0001697_abnormal_embryo_size0.37212834
140MP0003786_premature_aging0.36833336
141MP0003183_abnormal_peptide_metabolism0.36507116
142MP0005174_abnormal_tail_pigmentation0.36305887
143MP0000716_abnormal_immune_system0.35700467
144MP0002723_abnormal_immune_serum0.35382895
145MP0002722_abnormal_immune_system0.34723552
146MP0005380_embryogenesis_phenotype0.34682478
147MP0001672_abnormal_embryogenesis/_devel0.34682478
148MP0002971_abnormal_brown_adipose0.34458250
149MP0003011_delayed_dark_adaptation0.34335768
150MP0000534_abnormal_ureter_morphology0.34066182
151MP0006082_CNS_inflammation0.33984370
152MP0002452_abnormal_antigen_presenting0.32967612
153MP0002429_abnormal_blood_cell0.32196560
154MP0004197_abnormal_fetal_growth/weight/0.30717216
155MP0001849_ear_inflammation0.30620487
156MP0002420_abnormal_adaptive_immunity0.30608244
157MP0001835_abnormal_antigen_presentation0.30550179
158MP0001819_abnormal_immune_cell0.30428470
159MP0005391_vision/eye_phenotype0.29704039
160MP0002080_prenatal_lethality0.28772976
161MP0003984_embryonic_growth_retardation0.28114039
162MP0003091_abnormal_cell_migration0.27812288
163MP0004130_abnormal_muscle_cell0.27524680
164MP0000733_abnormal_muscle_development0.26424525
165MP0003329_amyloid_beta_deposits0.26237334
166MP0002019_abnormal_tumor_incidence0.26222456
167MP0003943_abnormal_hepatobiliary_system0.26210847
168MP0002092_abnormal_eye_morphology0.25843592
169MP0002088_abnormal_embryonic_growth/wei0.25148299
170MP0005253_abnormal_eye_physiology0.25053527
171MP0005257_abnormal_intraocular_pressure0.24716131
172MP0005464_abnormal_platelet_physiology0.24607605
173MP0000350_abnormal_cell_proliferation0.24208227
174MP0003705_abnormal_hypodermis_morpholog0.23858217
175MP0003861_abnormal_nervous_system0.23742494

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)8.88493469
2Abnormal respiratory motile cilium morphology (HP:0005938)8.88493469
3Abnormal respiratory motile cilium physiology (HP:0012261)8.54436312
4Rhinitis (HP:0012384)7.43687383
5Nasal polyposis (HP:0100582)7.13794170
6Chronic bronchitis (HP:0004469)6.87129535
7Infertility (HP:0000789)6.52581224
8Abnormal ciliary motility (HP:0012262)6.50365253
9Abnormality of the nasal mucosa (HP:0000433)5.91924513
10Bronchitis (HP:0012387)4.84694434
11Bronchiectasis (HP:0002110)4.71220408
12Pancreatic cysts (HP:0001737)4.54296353
13Nephronophthisis (HP:0000090)4.12543918
14Male infertility (HP:0003251)4.08711740
15Pancreatic fibrosis (HP:0100732)3.97925318
16Chronic hepatic failure (HP:0100626)3.93194254
17True hermaphroditism (HP:0010459)3.82265560
18Attenuation of retinal blood vessels (HP:0007843)3.54865192
19Recurrent bronchitis (HP:0002837)3.49737701
20Recurrent otitis media (HP:0000403)3.49397578
21Recurrent sinusitis (HP:0011108)3.48685917
22Abnormal spermatogenesis (HP:0008669)3.46437389
23Abnormal rod and cone electroretinograms (HP:0008323)3.14571586
24Congenital stationary night blindness (HP:0007642)3.14047881
25Abolished electroretinogram (ERG) (HP:0000550)3.06240357
26Abnormality of the renal medulla (HP:0100957)3.05711647
27Severe visual impairment (HP:0001141)2.98154983
28Bony spicule pigmentary retinopathy (HP:0007737)2.94481235
29Impulsivity (HP:0100710)2.93647805
30Gaze-evoked nystagmus (HP:0000640)2.93421460
31Cystic liver disease (HP:0006706)2.86411839
32Tubular atrophy (HP:0000092)2.84338127
33Amelogenesis imperfecta (HP:0000705)2.82341449
34Abnormality of midbrain morphology (HP:0002418)2.72823802
35Molar tooth sign on MRI (HP:0002419)2.72823802
36Focal motor seizures (HP:0011153)2.68878218
37Abnormality of macular pigmentation (HP:0008002)2.68756950
38Medial flaring of the eyebrow (HP:0010747)2.68590060
39Hyperventilation (HP:0002883)2.67148642
40Progressive cerebellar ataxia (HP:0002073)2.66716865
41Increased corneal curvature (HP:0100692)2.55015220
42Keratoconus (HP:0000563)2.55015220
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.53087978
44Congenital sensorineural hearing impairment (HP:0008527)2.45909062
45Hypoplasia of the pons (HP:0012110)2.45383272
46Azoospermia (HP:0000027)2.44230646
47Polyuria (HP:0000103)2.43013808
48Optic nerve hypoplasia (HP:0000609)2.41758002
49Abnormal gallbladder physiology (HP:0012438)2.37360171
50Cholecystitis (HP:0001082)2.37360171
51Retinal atrophy (HP:0001105)2.34535003
52Inability to walk (HP:0002540)2.34359552
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.32967768
54Pendular nystagmus (HP:0012043)2.32770617
55Abnormality of the pons (HP:0007361)2.31781692
56Male pseudohermaphroditism (HP:0000037)2.31306595
57Chronic sinusitis (HP:0011109)2.27000040
58Tubulointerstitial nephritis (HP:0001970)2.25147429
59Heterotopia (HP:0002282)2.24885800
60Aplasia/Hypoplasia of the tibia (HP:0005772)2.21194365
61Progressive inability to walk (HP:0002505)2.20996607
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19847953
63Anencephaly (HP:0002323)2.18098697
64Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.17764774
65Gonadotropin excess (HP:0000837)2.17293529
66Intestinal atresia (HP:0011100)2.15899010
67Tubulointerstitial abnormality (HP:0001969)2.14598206
68Sclerocornea (HP:0000647)2.13938119
69Aplasia/Hypoplasia of the tongue (HP:0010295)2.09034104
70Febrile seizures (HP:0002373)2.08114274
71Occipital encephalocele (HP:0002085)2.02981428
72Genetic anticipation (HP:0003743)2.02339912
73Spastic tetraparesis (HP:0001285)2.01504604
74Large for gestational age (HP:0001520)2.01218808
75Furrowed tongue (HP:0000221)2.00391920
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.00182991
77Absent/shortened dynein arms (HP:0200106)12.3725303
78Dynein arm defect of respiratory motile cilia (HP:0012255)12.3725303
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3386379
80Aplasia/hypoplasia of the uterus (HP:0008684)1.98521989
81Dialeptic seizures (HP:0011146)1.95861762
82Hypoplasia of the uterus (HP:0000013)1.93843899
83Stomach cancer (HP:0012126)1.92692245
84Focal seizures (HP:0007359)1.91186181
85Tubulointerstitial fibrosis (HP:0005576)1.89667172
86Decreased circulating renin level (HP:0003351)1.85822764
87Dyschromatopsia (HP:0007641)1.85049775
88Choroideremia (HP:0001139)1.83601419
89Absent speech (HP:0001344)1.83102339
90Abnormality of the lower motor neuron (HP:0002366)1.82739081
91Type II lissencephaly (HP:0007260)1.81143897
92Pachygyria (HP:0001302)1.80292205
93Protruding tongue (HP:0010808)1.77655684
94Macular degeneration (HP:0000608)1.77145910
95Severe muscular hypotonia (HP:0006829)1.76517709
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.76125002
97Abnormality of alanine metabolism (HP:0010916)1.76125002
98Hyperalaninemia (HP:0003348)1.76125002
99Atonic seizures (HP:0010819)1.75284591
100Polydipsia (HP:0001959)1.74764732
101Abnormal drinking behavior (HP:0030082)1.74764732
102Type II diabetes mellitus (HP:0005978)1.73634630
103Photophobia (HP:0000613)1.72603469
104Genital tract atresia (HP:0001827)1.71993370
105Loss of speech (HP:0002371)1.71557474
106Hypoplastic ischia (HP:0003175)1.70905574
107Stage 5 chronic kidney disease (HP:0003774)1.69809640
108Easy fatigability (HP:0003388)1.69637498
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68306812
110Absent epiphyses (HP:0010577)1.68306812
111Colon cancer (HP:0003003)1.68166100
112Postaxial foot polydactyly (HP:0001830)1.67974464
113Congenital primary aphakia (HP:0007707)1.66883749
114Clumsiness (HP:0002312)1.66708213
115Gait imbalance (HP:0002141)1.64725116
116Retinal dysplasia (HP:0007973)1.63504937
117Abnormality of the neuromuscular junction (HP:0003398)1.63216573
118Fatigable weakness (HP:0003473)1.63216573
119Bundle branch block (HP:0011710)1.61504084
120Short ribs (HP:0000773)1.61256516
121Chronic otitis media (HP:0000389)1.60207878
122Congenital hepatic fibrosis (HP:0002612)1.60133100
123Hemorrhage of the eye (HP:0011885)1.59789765
124Aplasia/Hypoplasia of the lens (HP:0008063)1.57331423
125Cerebellar dysplasia (HP:0007033)1.56336918
126Decreased central vision (HP:0007663)1.55958961
127Oculomotor apraxia (HP:0000657)1.55504616
128Bell-shaped thorax (HP:0001591)1.52171934
129Abnormality of renal excretion (HP:0011036)1.50113392
130Deformed sella turcica (HP:0002681)1.48719608
131Abnormality of ocular smooth pursuit (HP:0000617)1.44360894
132Abnormality of the renal cortex (HP:0011035)1.44251286
133Postaxial hand polydactyly (HP:0001162)1.43174316
134Renal dysplasia (HP:0000110)1.42671414
135Facial cleft (HP:0002006)1.42523503
136Nephrogenic diabetes insipidus (HP:0009806)1.41758725
137Abnormality of saccadic eye movements (HP:0000570)1.40054787
138Short thorax (HP:0010306)1.38689000
139Abnormal biliary tract physiology (HP:0012439)1.38379628
140Bile duct proliferation (HP:0001408)1.38379628
141Short femoral neck (HP:0100864)1.37622440
142Asymmetric septal hypertrophy (HP:0001670)1.35335310
143Amyotrophic lateral sclerosis (HP:0007354)1.32144888
144Anterior segment dysgenesis (HP:0007700)1.30631993
145Microglossia (HP:0000171)1.28873998
146Truncal obesity (HP:0001956)1.28713261
147Absent frontal sinuses (HP:0002688)1.28156225
148Polymicrogyria (HP:0002126)1.27077913
149Type 2 muscle fiber atrophy (HP:0003554)1.26224509
150Generalized muscle weakness (HP:0003324)1.26114640
151Poor coordination (HP:0002370)1.24506709
152Abnormal urine output (HP:0012590)1.23818631
153Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22675811
154Hemiparesis (HP:0001269)1.22552349
155Difficulty climbing stairs (HP:0003551)1.20713107
156Supernumerary spleens (HP:0009799)1.20137142
157Double outlet right ventricle (HP:0001719)1.19853603
158Congenital malformation of the right heart (HP:0011723)1.19853603
159Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.18528572
160Lissencephaly (HP:0001339)1.18448133
161Sensory axonal neuropathy (HP:0003390)1.17861172
162Impaired smooth pursuit (HP:0007772)1.17663403
163Vaginal atresia (HP:0000148)1.15970441
164Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.14106555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK17.68245455
2PDK36.81813822
3PDK46.81813822
4FRK6.16827810
5PRKD35.48690980
6ICK5.08000585
7PDK24.30234430
8PINK13.89995938
9STK38L2.92466940
10LATS12.82799796
11BMPR1B2.69345898
12INSRR2.64591250
13ZAK2.57997917
14ADRBK22.56130303
15PTK2B2.28145212
16ACVR1B2.25461554
17NEK22.25129125
18TAOK32.00003975
19MAP4K21.98014848
20WNK31.96338840
21NUAK11.94061862
22STK381.88932994
23NTRK31.87864946
24GRK11.86221884
25CDK121.83637025
26EEF2K1.78496426
27CASK1.69878667
28TLK11.68599236
29WNK41.62935968
30DYRK1B1.62760573
31MAPK131.58757355
32PLK21.47192360
33PNCK1.43857526
34NLK1.42374774
35TNIK1.37838073
36STK391.37199073
37MAP3K41.35812007
38TESK21.29300965
39TAF11.24450662
40TXK1.18165841
41PDK11.17092064
42OXSR11.14959075
43PIK3CG1.09326700
44DAPK21.08180902
45DYRK31.04774902
46PAK31.00010493
47CSNK1G20.96329905
48TRIM280.96215092
49ADRBK10.96078698
50CSNK1A1L0.95923775
51MAP3K100.94492850
52TYRO30.94112375
53PASK0.92237860
54PRKCE0.90851030
55CHEK20.89330596
56MAP2K70.89241700
57MARK10.87448855
58CSNK1G10.86958590
59CSNK1G30.85877793
60MKNK20.78700753
61DYRK20.72815865
62MAP4K10.72514844
63TNK20.71067615
64RPS6KA50.70951260
65STK30.70141673
66MAP2K20.70000822
67TGFBR10.69457391
68IRAK10.69187038
69MAPK150.68373573
70PDPK10.67925536
71CAMK1G0.67762626
72EIF2AK30.64517342
73VRK10.61847587
74IKBKB0.61722880
75MAP2K60.61359475
76STK100.59547411
77CDK30.57823400
78WNK10.57687683
79TIE10.57153766
80TEC0.56512261
81PRKAA20.56055476
82TTK0.55646661
83MTOR0.52647902
84ERN10.52320015
85CCNB10.51856395
86CSF1R0.51268464
87RIPK40.51219372
88CHEK10.50898355
89ERBB30.50228010
90CAMKK20.49711251
91GRK50.46302784
92PAK40.45278972
93CAMK2A0.43396596
94PRKG10.43192398
95TRIB30.42998838
96PDGFRA0.42232408
97PAK20.42217645
98LMTK20.41970372
99PKN10.41660226
100BRD40.41367867
101PLK40.41240138
102OBSCN0.40522205
103PAK10.40275776
104FER0.39986346
105ZAP700.39801690
106MARK20.37574002
107ATR0.37534447
108PRKACA0.36767572
109FGFR20.36612621
110CAMK10.35660251
111RIPK10.34446857
112ATM0.34189288
113CSNK1A10.34019166
114GRK60.33673930
115KIT0.32914150
116CDK60.32849231
117AKT30.32104313
118MARK30.31478708
119LATS20.31170765
120CDC70.31100726
121PDGFRB0.31090085
122PIM10.31002607
123MST40.30599650
124PHKG20.30395073
125PHKG10.30395073
126DYRK1A0.30154369
127CHUK0.29546390
128GRK70.28022519
129SGK4940.26636158
130SGK2230.26636158
131EPHA40.26623665
132PRKACB0.26573449
133MELK0.26248026
134PIK3CA0.25781336
135PRKAA10.24013672
136IRAK20.23401260
137CDK40.22396948
138PRKCQ0.22395427
139MUSK0.20763084
140YES10.19062292
141CSK0.17998011
142WEE10.17550840
143NTRK20.17083033
144RPS6KB10.16785671
145CDK70.16618824
146BTK0.15960955
147TTN0.15061317
148PLK10.14222255
149RPS6KA10.13620698
150STK40.13462492
151TYK20.13024756
152PRKG20.12906689
153LCK0.11010375
154CDK20.10745401
155HCK0.10020748
156EGFR0.09775478
157CSNK1D0.09675269
158PKN20.08832411
159EPHB10.07863619
160CAMKK10.07764673
161TGFBR20.07677326
162GSK3B0.07319493
163PRKD20.06893251
164PTK60.06314920
165MAP3K50.05584407
166MAPK40.05461396
167BRSK20.04622721
168SYK0.04302887
169CLK10.04069459
170MAPKAPK30.03973007
171ITK0.03874111
172STK110.02696306
173CDK10.02651534
174MAP3K110.02301160
175MAPK80.01022177
176PRKCG0.00355206
177NEK60.00338974

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.40191836
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.88693716
3Phototransduction_Homo sapiens_hsa047443.20689251
4Pyruvate metabolism_Homo sapiens_hsa006203.11310958
5Butanoate metabolism_Homo sapiens_hsa006502.95865205
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.95555224
7Selenocompound metabolism_Homo sapiens_hsa004502.82915802
8Nitrogen metabolism_Homo sapiens_hsa009102.80523752
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.68435297
10Nicotine addiction_Homo sapiens_hsa050332.57573171
11Olfactory transduction_Homo sapiens_hsa047402.52624533
12Basal transcription factors_Homo sapiens_hsa030222.47646440
13Linoleic acid metabolism_Homo sapiens_hsa005912.44853163
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.43161941
15Propanoate metabolism_Homo sapiens_hsa006402.42725474
16Vitamin B6 metabolism_Homo sapiens_hsa007502.39195438
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.34572667
18Glucagon signaling pathway_Homo sapiens_hsa049222.31550201
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.29801277
20Glycerolipid metabolism_Homo sapiens_hsa005612.25566409
21Taste transduction_Homo sapiens_hsa047422.23822823
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20092288
23Pentose phosphate pathway_Homo sapiens_hsa000302.14787628
24Glycosaminoglycan degradation_Homo sapiens_hsa005312.11116069
25Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.01664403
26Sulfur relay system_Homo sapiens_hsa041222.01270378
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.95360236
28Fanconi anemia pathway_Homo sapiens_hsa034601.93714534
29Tryptophan metabolism_Homo sapiens_hsa003801.88200155
30Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.87632409
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81368360
32PPAR signaling pathway_Homo sapiens_hsa033201.74253358
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73393231
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70552871
35Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.63334134
36Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.60893323
37Antigen processing and presentation_Homo sapiens_hsa046121.60669966
38Morphine addiction_Homo sapiens_hsa050321.57869643
39Fructose and mannose metabolism_Homo sapiens_hsa000511.57659519
40Oocyte meiosis_Homo sapiens_hsa041141.44549705
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.44340078
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.43444325
43Steroid hormone biosynthesis_Homo sapiens_hsa001401.43195688
44Systemic lupus erythematosus_Homo sapiens_hsa053221.31548123
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30731498
46mRNA surveillance pathway_Homo sapiens_hsa030151.30228932
47Fatty acid degradation_Homo sapiens_hsa000711.28132415
48Fat digestion and absorption_Homo sapiens_hsa049751.27580744
49Fatty acid metabolism_Homo sapiens_hsa012121.27185114
50Carbon metabolism_Homo sapiens_hsa012001.26972288
51Dorso-ventral axis formation_Homo sapiens_hsa043201.26680118
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.25903425
53Circadian entrainment_Homo sapiens_hsa047131.23817848
54Primary bile acid biosynthesis_Homo sapiens_hsa001201.20249843
55Serotonergic synapse_Homo sapiens_hsa047261.17873762
56Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17435100
57GABAergic synapse_Homo sapiens_hsa047271.15689254
58RNA transport_Homo sapiens_hsa030131.15644734
59B cell receptor signaling pathway_Homo sapiens_hsa046621.15011061
60Glutamatergic synapse_Homo sapiens_hsa047241.14924257
61Retinol metabolism_Homo sapiens_hsa008301.14068933
62Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10958105
63Glutathione metabolism_Homo sapiens_hsa004801.09440274
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05690686
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04806150
66Caffeine metabolism_Homo sapiens_hsa002321.04393747
67Central carbon metabolism in cancer_Homo sapiens_hsa052301.03101135
68Amphetamine addiction_Homo sapiens_hsa050311.01080473
69Intestinal immune network for IgA production_Homo sapiens_hsa046721.00004075
70Asthma_Homo sapiens_hsa053100.99071000
71Mineral absorption_Homo sapiens_hsa049780.98905753
72RNA polymerase_Homo sapiens_hsa030200.96314398
73Salivary secretion_Homo sapiens_hsa049700.95380482
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.95301198
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.95260012
76Peroxisome_Homo sapiens_hsa041460.95035161
77DNA replication_Homo sapiens_hsa030300.94705498
78N-Glycan biosynthesis_Homo sapiens_hsa005100.90498180
79beta-Alanine metabolism_Homo sapiens_hsa004100.88897223
80Autoimmune thyroid disease_Homo sapiens_hsa053200.87577541
81Regulation of autophagy_Homo sapiens_hsa041400.84922080
82Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84543460
83Sphingolipid metabolism_Homo sapiens_hsa006000.84519854
84Ether lipid metabolism_Homo sapiens_hsa005650.84023358
85Oxidative phosphorylation_Homo sapiens_hsa001900.83202364
86Type I diabetes mellitus_Homo sapiens_hsa049400.82608440
87Graft-versus-host disease_Homo sapiens_hsa053320.82113522
88Allograft rejection_Homo sapiens_hsa053300.80915908
89Estrogen signaling pathway_Homo sapiens_hsa049150.79795435
90VEGF signaling pathway_Homo sapiens_hsa043700.78322330
91Renin-angiotensin system_Homo sapiens_hsa046140.77468809
92Renin secretion_Homo sapiens_hsa049240.75940562
93Legionellosis_Homo sapiens_hsa051340.74682794
94Histidine metabolism_Homo sapiens_hsa003400.74251389
95Hedgehog signaling pathway_Homo sapiens_hsa043400.73443603
96Purine metabolism_Homo sapiens_hsa002300.73365291
97Cardiac muscle contraction_Homo sapiens_hsa042600.70978773
98ABC transporters_Homo sapiens_hsa020100.68558638
99Protein export_Homo sapiens_hsa030600.68339189
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.67718632
101One carbon pool by folate_Homo sapiens_hsa006700.65449098
102Biosynthesis of amino acids_Homo sapiens_hsa012300.64619910
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64236287
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.64036081
105Inositol phosphate metabolism_Homo sapiens_hsa005620.63364475
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61651613
107Viral carcinogenesis_Homo sapiens_hsa052030.61298164
108Alcoholism_Homo sapiens_hsa050340.60505235
109T cell receptor signaling pathway_Homo sapiens_hsa046600.59458679
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56249693
111Ovarian steroidogenesis_Homo sapiens_hsa049130.56196124
112Thyroid hormone synthesis_Homo sapiens_hsa049180.56037541
113Parkinsons disease_Homo sapiens_hsa050120.54571437
114Circadian rhythm_Homo sapiens_hsa047100.54212010
115Metabolic pathways_Homo sapiens_hsa011000.54028744
116cAMP signaling pathway_Homo sapiens_hsa040240.52456203
117Endocytosis_Homo sapiens_hsa041440.51891312
118AMPK signaling pathway_Homo sapiens_hsa041520.51854026
119Bile secretion_Homo sapiens_hsa049760.51609907
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.51181591
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50416799
122Collecting duct acid secretion_Homo sapiens_hsa049660.49881120
123Primary immunodeficiency_Homo sapiens_hsa053400.49535616
124Huntingtons disease_Homo sapiens_hsa050160.48268818
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47640309
126Cholinergic synapse_Homo sapiens_hsa047250.47469171
127Dopaminergic synapse_Homo sapiens_hsa047280.45422323
128Measles_Homo sapiens_hsa051620.43891745
129Arachidonic acid metabolism_Homo sapiens_hsa005900.43830208
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.43304156
131Long-term depression_Homo sapiens_hsa047300.42951125
132Long-term potentiation_Homo sapiens_hsa047200.42726036
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42408519
134RNA degradation_Homo sapiens_hsa030180.41354055
135Protein digestion and absorption_Homo sapiens_hsa049740.39653285
136Insulin secretion_Homo sapiens_hsa049110.39085761
137Gastric acid secretion_Homo sapiens_hsa049710.39081801
138Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.37940657
139Toxoplasmosis_Homo sapiens_hsa051450.37858237
140Oxytocin signaling pathway_Homo sapiens_hsa049210.37759211
141Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36694788
142Lysine degradation_Homo sapiens_hsa003100.36603851
143Sulfur metabolism_Homo sapiens_hsa009200.36091310
144Insulin resistance_Homo sapiens_hsa049310.34730413
145Pancreatic secretion_Homo sapiens_hsa049720.34577521
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32659172
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31698187
148Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31236274
149Alzheimers disease_Homo sapiens_hsa050100.30516814
150Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30051777
151Homologous recombination_Homo sapiens_hsa034400.29705085
152HIF-1 signaling pathway_Homo sapiens_hsa040660.28995310
153Influenza A_Homo sapiens_hsa051640.28799196
154Mismatch repair_Homo sapiens_hsa034300.28715297
155Herpes simplex infection_Homo sapiens_hsa051680.28078311
156Chemical carcinogenesis_Homo sapiens_hsa052040.23906437
157Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.23557968
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22867205
159Calcium signaling pathway_Homo sapiens_hsa040200.22594059
160Salmonella infection_Homo sapiens_hsa051320.22342718
161Osteoclast differentiation_Homo sapiens_hsa043800.22299803
162Pyrimidine metabolism_Homo sapiens_hsa002400.22234890
163Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.21419359
164Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21179189

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