FBXO25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.24366128
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.21779958
3vocalization behavior (GO:0071625)4.95102601
4neuron cell-cell adhesion (GO:0007158)4.86115534
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.70851883
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.66434841
7protein localization to synapse (GO:0035418)4.56263609
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.55932295
9regulation of synaptic vesicle exocytosis (GO:2000300)4.55040445
10synaptic vesicle maturation (GO:0016188)4.49545930
11glutamate secretion (GO:0014047)4.45410616
12locomotory exploration behavior (GO:0035641)4.41640886
13regulation of glutamate receptor signaling pathway (GO:1900449)4.34877036
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.07919712
15regulation of synaptic vesicle transport (GO:1902803)4.05357687
16neuronal action potential propagation (GO:0019227)4.02332954
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00790809
18neurotransmitter secretion (GO:0007269)3.91129263
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.88959603
20layer formation in cerebral cortex (GO:0021819)3.86981552
21neuron-neuron synaptic transmission (GO:0007270)3.77317477
22neuron recognition (GO:0008038)3.75835940
23exploration behavior (GO:0035640)3.75606713
24regulation of neuronal synaptic plasticity (GO:0048168)3.72050533
25positive regulation of synapse maturation (GO:0090129)3.71210256
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70660249
27synaptic transmission, glutamatergic (GO:0035249)3.67588123
28regulation of synapse structural plasticity (GO:0051823)3.67311405
29glutamate receptor signaling pathway (GO:0007215)3.63237872
30response to histamine (GO:0034776)3.61122346
31synaptic vesicle endocytosis (GO:0048488)3.59722286
32neural tube formation (GO:0001841)3.57893330
33drug catabolic process (GO:0042737)3.57247305
34gamma-aminobutyric acid signaling pathway (GO:0007214)3.54075401
35indole-containing compound catabolic process (GO:0042436)3.50803745
36indolalkylamine catabolic process (GO:0046218)3.50803745
37tryptophan catabolic process (GO:0006569)3.50803745
38dendritic spine morphogenesis (GO:0060997)3.50370758
39presynaptic membrane assembly (GO:0097105)3.49963344
40neurotransmitter-gated ion channel clustering (GO:0072578)3.46354260
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.41953791
42pyrimidine nucleobase catabolic process (GO:0006208)3.39070689
43presynaptic membrane organization (GO:0097090)3.38769165
44long-term synaptic potentiation (GO:0060291)3.38107118
45regulation of excitatory postsynaptic membrane potential (GO:0060079)3.37848667
46positive regulation of membrane potential (GO:0045838)3.35994464
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35736926
48postsynaptic membrane organization (GO:0001941)3.35682580
49neurotransmitter transport (GO:0006836)3.34828216
50protein K11-linked deubiquitination (GO:0035871)3.34183320
51axonal fasciculation (GO:0007413)3.33638152
52proline transport (GO:0015824)3.33288896
53positive regulation of synaptic transmission, GABAergic (GO:0032230)3.32199097
54establishment of protein localization to Golgi (GO:0072600)3.32191074
55exogenous drug catabolic process (GO:0042738)3.26542792
56righting reflex (GO:0060013)3.26484902
57transmission of nerve impulse (GO:0019226)3.25980929
58long-term memory (GO:0007616)3.25713956
59regulation of postsynaptic membrane potential (GO:0060078)3.25542405
60cytoplasmic mRNA processing body assembly (GO:0033962)3.20557751
61regulation of synaptic plasticity (GO:0048167)3.19210148
62behavioral response to cocaine (GO:0048148)3.18951659
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.17630021
64detection of calcium ion (GO:0005513)3.14420333
65negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10105771
66regulation of neurotransmitter secretion (GO:0046928)3.09844758
67activation of protein kinase A activity (GO:0034199)3.09412475
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.08617638
69membrane hyperpolarization (GO:0060081)3.05039208
70regulation of neurotransmitter levels (GO:0001505)3.03870369
71regulation of vesicle fusion (GO:0031338)3.00829665
72indolalkylamine metabolic process (GO:0006586)3.00572441
73regulation of synapse maturation (GO:0090128)3.00139227
74regulation of glutamate secretion (GO:0014048)2.99717116
75regulation of dendritic spine morphogenesis (GO:0061001)2.98901172
76innervation (GO:0060384)2.98332059
77synapse assembly (GO:0007416)2.97906600
78adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.97236473
79positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96603292
80behavioral fear response (GO:0001662)2.96088471
81behavioral defense response (GO:0002209)2.96088471
82negative regulation of neurotransmitter transport (GO:0051589)2.94969358
83gamma-aminobutyric acid transport (GO:0015812)2.94883993
84energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.94211136
85ATP hydrolysis coupled proton transport (GO:0015991)2.94211136
86cellular ketone body metabolic process (GO:0046950)2.93985063
87nucleobase catabolic process (GO:0046113)2.92858018
88positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.91507340
89regulation of neurotransmitter transport (GO:0051588)2.91127351
90cerebellar granule cell differentiation (GO:0021707)2.90310037
91cellular potassium ion homeostasis (GO:0030007)2.90247377
92positive regulation of synapse assembly (GO:0051965)2.90136105
93mating behavior (GO:0007617)2.90064887
94auditory behavior (GO:0031223)2.89927647
95G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.89855341
96regulation of synaptic transmission, GABAergic (GO:0032228)2.89829787
97bile acid biosynthetic process (GO:0006699)2.89005589
98cerebellar Purkinje cell differentiation (GO:0021702)2.88864765
99glyoxylate metabolic process (GO:0046487)2.88388186
100tryptophan metabolic process (GO:0006568)2.88300772
101startle response (GO:0001964)2.87690030
102detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87103358
103synaptic transmission (GO:0007268)2.87006301
104vesicle transport along microtubule (GO:0047496)2.85993543
105learning (GO:0007612)2.85255838
106cell migration in hindbrain (GO:0021535)2.84941177
107fear response (GO:0042596)2.82652038
108establishment of synaptic vesicle localization (GO:0097480)2.82455834
109synaptic vesicle transport (GO:0048489)2.82455834
110androgen biosynthetic process (GO:0006702)2.82212642
111regulation of voltage-gated calcium channel activity (GO:1901385)2.81540814
112striatum development (GO:0021756)2.81308816
113positive regulation of synaptic transmission (GO:0050806)2.80459087
114regulation of synaptic transmission (GO:0050804)2.80054721
115L-methionine salvage (GO:0071267)2.79976481
116L-methionine biosynthetic process (GO:0071265)2.79976481
117amino acid salvage (GO:0043102)2.79976481
118positive regulation of neurotransmitter secretion (GO:0001956)2.79534017
119reflex (GO:0060004)2.79235637
120transferrin transport (GO:0033572)2.79040578
121positive regulation of neurotransmitter transport (GO:0051590)2.79036010
122membrane depolarization (GO:0051899)2.77694246
123synaptic transmission, dopaminergic (GO:0001963)2.76725691
124indole-containing compound metabolic process (GO:0042430)2.76581820
125aromatic amino acid family catabolic process (GO:0009074)2.75719779
126omega-hydroxylase P450 pathway (GO:0097267)2.75371198
127protein targeting to Golgi (GO:0000042)2.75025002
128regulation of pigment cell differentiation (GO:0050932)2.74538031
129response to pheromone (GO:0019236)2.74016975
130macroautophagy (GO:0016236)2.72374965
131negative regulation of cytosolic calcium ion concentration (GO:0051481)2.69141126
132oxidative demethylation (GO:0070989)2.67208791
133negative regulation of translation, ncRNA-mediated (GO:0040033)2.65205599
134regulation of translation, ncRNA-mediated (GO:0045974)2.65205599
135negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65205599
136serotonin metabolic process (GO:0042428)2.64253883
137ketone body metabolic process (GO:1902224)2.61586860
138sex differentiation (GO:0007548)2.60874874
139S-adenosylmethionine metabolic process (GO:0046500)2.54616162
140cellular response to sterol (GO:0036315)2.53387296
141kynurenine metabolic process (GO:0070189)2.50752811
142benzene-containing compound metabolic process (GO:0042537)2.50608024
143bile acid metabolic process (GO:0008206)2.46049189
144protein localization to Golgi apparatus (GO:0034067)2.46048948
145flavonoid metabolic process (GO:0009812)2.45706179
146triglyceride homeostasis (GO:0070328)2.45437510
147acylglycerol homeostasis (GO:0055090)2.45437510
148retrograde transport, vesicle recycling within Golgi (GO:0000301)2.44790290
149retinal cone cell development (GO:0046549)2.43741447
150epoxygenase P450 pathway (GO:0019373)2.42812694
151primary amino compound metabolic process (GO:1901160)2.41067557
152L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40132602
153regulation of hippo signaling (GO:0035330)2.36573866
154C4-dicarboxylate transport (GO:0015740)2.36415235
155photoreceptor cell maintenance (GO:0045494)2.36102030
156coenzyme catabolic process (GO:0009109)2.35964034
157organic cation transport (GO:0015695)2.32225125
158detection of light stimulus involved in visual perception (GO:0050908)2.32216956
159detection of light stimulus involved in sensory perception (GO:0050962)2.32216956
160regulation of establishment of cell polarity (GO:2000114)2.31472975
161phenylpropanoid metabolic process (GO:0009698)2.30911642
162Golgi to endosome transport (GO:0006895)2.30524174
163cellular glucuronidation (GO:0052695)2.30161610
164cAMP catabolic process (GO:0006198)2.29508802
165negative regulation of sodium ion transport (GO:0010766)2.28662662
166cellular biogenic amine catabolic process (GO:0042402)2.27589756
167amine catabolic process (GO:0009310)2.27589756
168interkinetic nuclear migration (GO:0022027)2.27124846
169acrosome reaction (GO:0007340)2.26246653
170regulation of sarcomere organization (GO:0060297)2.24665603
171glycosphingolipid biosynthetic process (GO:0006688)2.24127834
172behavioral response to nicotine (GO:0035095)2.24096886
173thyroid hormone metabolic process (GO:0042403)2.24040030
174membrane depolarization during action potential (GO:0086010)2.22626238
175cilium or flagellum-dependent cell motility (GO:0001539)2.22548160
176piRNA metabolic process (GO:0034587)2.21751435
177dicarboxylic acid catabolic process (GO:0043649)2.21265231
178regulation of protein activation cascade (GO:2000257)2.20954453
179cyclic nucleotide catabolic process (GO:0009214)2.20928909
180androgen metabolic process (GO:0008209)2.20321130
181embryonic epithelial tube formation (GO:0001838)2.20310166
182ethanol oxidation (GO:0006069)2.20268283
183phospholipid translocation (GO:0045332)2.18482608
184lipid translocation (GO:0034204)2.18482608

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.47260048
2GBX2_23144817_ChIP-Seq_PC3_Human3.87677225
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15751204
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06567901
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.91264809
6REST_21632747_ChIP-Seq_MESCs_Mouse2.64593340
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62212967
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61247172
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.59708617
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.59708617
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50784134
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.47508994
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47178969
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44047283
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.43197888
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42269761
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.27820656
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.22007745
19DROSHA_22980978_ChIP-Seq_HELA_Human2.19606472
20EZH2_27294783_Chip-Seq_ESCs_Mouse2.16989034
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13312381
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11640544
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.05518646
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01825584
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97951046
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92334068
27TAF15_26573619_Chip-Seq_HEK293_Human1.89392915
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83975959
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83852164
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78803682
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.77397856
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69310993
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.69138316
34AR_21572438_ChIP-Seq_LNCaP_Human1.68450327
35SMAD4_21799915_ChIP-Seq_A2780_Human1.68098779
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.64128780
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63329245
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62018124
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.60526665
40BCAT_22108803_ChIP-Seq_LS180_Human1.60063123
41P300_19829295_ChIP-Seq_ESCs_Human1.57750768
42CBP_20019798_ChIP-Seq_JUKART_Human1.57009046
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57009046
44EWS_26573619_Chip-Seq_HEK293_Human1.56509841
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54884874
46ZNF274_21170338_ChIP-Seq_K562_Hela1.52359643
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.52212578
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52108938
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51303096
50NR3C1_23031785_ChIP-Seq_PC12_Mouse1.51238511
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49683573
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49355590
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47014233
54TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45039278
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42593080
56ESR1_20079471_ChIP-ChIP_T-47D_Human1.41854730
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40617060
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39232510
59CBX2_27304074_Chip-Seq_ESCs_Mouse1.38444267
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.38052092
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.37410243
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35638284
63SOX2_21211035_ChIP-Seq_LN229_Gbm1.35167788
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.34798767
65* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32660883
66KLF5_20875108_ChIP-Seq_MESCs_Mouse1.32281593
67TCF4_22108803_ChIP-Seq_LS180_Human1.30888405
68PIAS1_25552417_ChIP-Seq_VCAP_Human1.30641061
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25676176
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.25662221
71POU3F2_20337985_ChIP-ChIP_501MEL_Human1.25589979
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24814198
73STAT3_23295773_ChIP-Seq_U87_Human1.24572902
74AR_25329375_ChIP-Seq_VCAP_Human1.22635639
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21707163
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21700403
77CDX2_22108803_ChIP-Seq_LS180_Human1.21685009
78TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21330595
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21330595
80SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20814411
81FUS_26573619_Chip-Seq_HEK293_Human1.20560708
82VDR_22108803_ChIP-Seq_LS180_Human1.19576663
83SMAD4_21741376_ChIP-Seq_EPCs_Human1.18497275
84ER_23166858_ChIP-Seq_MCF-7_Human1.18065721
85TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17878524
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.17794104
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.16088116
88RING1B_27294783_Chip-Seq_ESCs_Mouse1.15673877
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.15065663
90RNF2_27304074_Chip-Seq_NSC_Mouse1.13424420
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13063642
92* AR_19668381_ChIP-Seq_PC3_Human1.12056845
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.11890640
94IGF1R_20145208_ChIP-Seq_DFB_Human1.11832918
95NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11718841
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11718841
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.11276742
98EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11186930
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.10313977
100TCF4_18268006_ChIP-ChIP_LS174T_Human1.10147892
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09478030
102VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08091115
103RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07478912
104* TCF4_23295773_ChIP-Seq_U87_Human1.07421851
105EGR1_23403033_ChIP-Seq_LIVER_Mouse1.07258947
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07141309
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06880354
108JUN_21703547_ChIP-Seq_K562_Human1.06583727
109* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06425735
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06387189
111* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06292805
112P53_22387025_ChIP-Seq_ESCs_Mouse1.05931911
113KDM2B_26808549_Chip-Seq_REH_Human1.04742924
114TAL1_26923725_Chip-Seq_HPCs_Mouse1.04739533
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03925613
116ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03754374
117EP300_21415370_ChIP-Seq_HL-1_Mouse1.03649535
118TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03643098
119AHR_22903824_ChIP-Seq_MCF-7_Human1.02531145
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02373589
121RUNX2_22187159_ChIP-Seq_PCA_Human1.02344635
122AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01606843
123E2F1_18555785_Chip-Seq_ESCs_Mouse1.01158195
124STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00845413
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00458568
126YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00155928
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99830678
128* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99437385
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.95999150
130CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94584652
131SMAD3_21741376_ChIP-Seq_ESCs_Human0.94083491
132NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91342240
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90911175
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90237486
135TP53_18474530_ChIP-ChIP_U2OS_Human0.89862242
136DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89431629
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.86593185
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86561211
139PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84509209
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.82855813
141FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.82397117
142TP53_16413492_ChIP-PET_HCT116_Human0.81519938
143ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81435818
144SOX9_26525672_Chip-Seq_HEART_Mouse0.81158334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.40342166
2MP0003880_abnormal_central_pattern4.69371103
3MP0003635_abnormal_synaptic_transmissio3.79244541
4MP0004270_analgesia3.56639759
5MP0002822_catalepsy3.52093426
6MP0009745_abnormal_behavioral_response3.24469686
7MP0002063_abnormal_learning/memory/cond3.11461699
8MP0002064_seizures3.07386384
9MP0001968_abnormal_touch/_nociception3.03923035
10MP0003195_calcinosis2.90395357
11MP0009046_muscle_twitch2.80824991
12MP0002572_abnormal_emotion/affect_behav2.73572464
13MP0002734_abnormal_mechanical_nocicepti2.58504273
14MP0002272_abnormal_nervous_system2.56207097
15MP0002736_abnormal_nociception_after2.55740008
16MP0003252_abnormal_bile_duct2.46149084
17MP0002735_abnormal_chemical_nociception2.41081823
18MP0005423_abnormal_somatic_nervous2.38671778
19MP0002139_abnormal_hepatobiliary_system2.33849868
20MP0001486_abnormal_startle_reflex2.28726592
21MP0003868_abnormal_feces_composition2.15883176
22MP0005085_abnormal_gallbladder_physiolo2.14877611
23MP0001440_abnormal_grooming_behavior2.13877073
24MP0002733_abnormal_thermal_nociception2.04172207
25MP0006276_abnormal_autonomic_nervous2.03229517
26MP0005187_abnormal_penis_morphology2.01968107
27MP0001501_abnormal_sleep_pattern2.01939053
28MP0008877_abnormal_DNA_methylation2.00999873
29MP0001970_abnormal_pain_threshold2.00866761
30MP0001529_abnormal_vocalization1.95739313
31MP0000778_abnormal_nervous_system1.95727675
32MP0002067_abnormal_sensory_capabilities1.91994686
33MP0003329_amyloid_beta_deposits1.86082071
34MP0009780_abnormal_chondrocyte_physiolo1.82226791
35MP0005670_abnormal_white_adipose1.80809492
36MP0002184_abnormal_innervation1.80269165
37MP0004924_abnormal_behavior1.79125484
38MP0005386_behavior/neurological_phenoty1.79125484
39MP0003122_maternal_imprinting1.72683825
40MP0010386_abnormal_urinary_bladder1.70641412
41MP0001984_abnormal_olfaction1.70031895
42MP0002557_abnormal_social/conspecific_i1.67657292
43MP0004811_abnormal_neuron_physiology1.66884729
44MP0000013_abnormal_adipose_tissue1.64943671
45MP0000569_abnormal_digit_pigmentation1.63114658
46MP0003646_muscle_fatigue1.61107510
47MP0002909_abnormal_adrenal_gland1.60451815
48MP0008875_abnormal_xenobiotic_pharmacok1.59680913
49MP0001905_abnormal_dopamine_level1.58099291
50MP0005360_urolithiasis1.57322775
51MP0002102_abnormal_ear_morphology1.55680512
52MP0005646_abnormal_pituitary_gland1.55274831
53MP0005645_abnormal_hypothalamus_physiol1.55221785
54MP0003787_abnormal_imprinting1.54613795
55MP0005365_abnormal_bile_salt1.54133660
56MP0000955_abnormal_spinal_cord1.52016544
57MP0008569_lethality_at_weaning1.44570142
58MP0003136_yellow_coat_color1.44166981
59MP0002138_abnormal_hepatobiliary_system1.43428099
60MP0002882_abnormal_neuron_morphology1.43222293
61MP0004858_abnormal_nervous_system1.41031348
62MP0001666_abnormal_nutrient_absorption1.40451432
63MP0004885_abnormal_endolymph1.38017141
64MP0002066_abnormal_motor_capabilities/c1.37868443
65MP0003183_abnormal_peptide_metabolism1.36396898
66MP0010329_abnormal_lipoprotein_level1.35337452
67MP0002837_dystrophic_cardiac_calcinosis1.33049335
68MP0001188_hyperpigmentation1.32735733
69MP0003879_abnormal_hair_cell1.29798335
70MP0004142_abnormal_muscle_tone1.28018093
71MP0002160_abnormal_reproductive_system1.19625210
72MP0003633_abnormal_nervous_system1.16361549
73MP0003890_abnormal_embryonic-extraembry1.14045718
74MP0001986_abnormal_taste_sensitivity1.13725404
75MP0005410_abnormal_fertilization1.10617698
76MP0002152_abnormal_brain_morphology1.10504644
77MP0000427_abnormal_hair_cycle1.10264026
78MP0002009_preneoplasia1.10018432
79MP0005394_taste/olfaction_phenotype1.09031491
80MP0005499_abnormal_olfactory_system1.09031491
81MP0002229_neurodegeneration1.08996434
82MP0003283_abnormal_digestive_organ1.07214963
83MP0002928_abnormal_bile_duct1.06743812
84MP0000751_myopathy1.06562695
85MP0005253_abnormal_eye_physiology1.05069936
86MP0005551_abnormal_eye_electrophysiolog1.05068052
87MP0004043_abnormal_pH_regulation1.05008728
88MP0003631_nervous_system_phenotype1.03627518
89MP0003718_maternal_effect1.02778535
90MP0001664_abnormal_digestion1.00385502
91MP0001502_abnormal_circadian_rhythm0.99976572
92MP0000920_abnormal_myelination0.99257726
93MP0003698_abnormal_male_reproductive0.98203014
94MP0001764_abnormal_homeostasis0.98086742
95MP0003634_abnormal_glial_cell0.96256218
96MP0005167_abnormal_blood-brain_barrier0.95753991
97MP0000631_abnormal_neuroendocrine_gland0.95680046
98MP0004742_abnormal_vestibular_system0.94382148
99MP0001756_abnormal_urination0.93951519
100MP0001963_abnormal_hearing_physiology0.93289949
101MP0003011_delayed_dark_adaptation0.90830525
102MP0002069_abnormal_eating/drinking_beha0.89986411
103MP0000383_abnormal_hair_follicle0.89228087
104MP0008872_abnormal_physiological_respon0.88006452
105MP0005647_abnormal_sex_gland0.86269481
106MP0004145_abnormal_muscle_electrophysio0.86154475
107MP0002752_abnormal_somatic_nervous0.86100241
108MP0005389_reproductive_system_phenotype0.86030790
109MP0009697_abnormal_copulation0.84816549
110MP0004019_abnormal_vitamin_homeostasis0.83811258
111MP0002118_abnormal_lipid_homeostasis0.83793200
112MP0002876_abnormal_thyroid_physiology0.82554024
113MP0003045_fibrosis0.81413875
114MP0006072_abnormal_retinal_apoptosis0.81342947
115MP0000230_abnormal_systemic_arterial0.80967452
116MP0005171_absent_coat_pigmentation0.80785284
117MP0004130_abnormal_muscle_cell0.80440234
118MP0004233_abnormal_muscle_weight0.79877157
119MP0005332_abnormal_amino_acid0.79437000
120MP0005623_abnormal_meninges_morphology0.78607888
121MP0001177_atelectasis0.78336857
122MP0001919_abnormal_reproductive_system0.76865580
123MP0003632_abnormal_nervous_system0.76848082
124MP0001485_abnormal_pinna_reflex0.75138375
125MP0000604_amyloidosis0.71231799
126MP0004085_abnormal_heartbeat0.68729803
127MP0008789_abnormal_olfactory_epithelium0.67945112
128MP0008874_decreased_physiological_sensi0.67762985
129MP0001299_abnormal_eye_distance/0.66344163
130MP0005535_abnormal_body_temperature0.65274060
131MP0001943_abnormal_respiration0.62164639
132MP0003861_abnormal_nervous_system0.60708024
133MP0002090_abnormal_vision0.60479570
134MP0003121_genomic_imprinting0.56956986
135MP0002751_abnormal_autonomic_nervous0.53364943
136MP0000026_abnormal_inner_ear0.53126460
137MP0000003_abnormal_adipose_tissue0.52960812
138MP0005409_darkened_coat_color0.52890169
139MP0000538_abnormal_urinary_bladder0.51557719
140MP0004484_altered_response_of0.50298081
141MP0004215_abnormal_myocardial_fiber0.50172599
142MP0002638_abnormal_pupillary_reflex0.50087909
143MP0003690_abnormal_glial_cell0.48733029

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.08149783
2Myokymia (HP:0002411)6.05037363
3Focal seizures (HP:0007359)5.10664963
4Visual hallucinations (HP:0002367)4.88870604
5Atonic seizures (HP:0010819)4.77106151
6Epileptic encephalopathy (HP:0200134)4.46101946
7Absence seizures (HP:0002121)4.00252206
8Febrile seizures (HP:0002373)3.80357876
9Type II lissencephaly (HP:0007260)3.75516123
10Dialeptic seizures (HP:0011146)3.74216717
11Hyperventilation (HP:0002883)3.58044996
12Chronic hepatic failure (HP:0100626)3.56816075
13Pheochromocytoma (HP:0002666)3.52767791
14Supranuclear gaze palsy (HP:0000605)3.48792064
15Progressive cerebellar ataxia (HP:0002073)3.39340071
16Ankle clonus (HP:0011448)3.34674656
17Generalized tonic-clonic seizures (HP:0002069)3.32206210
18Neuroendocrine neoplasm (HP:0100634)3.23985975
19Action tremor (HP:0002345)3.04615989
20Broad-based gait (HP:0002136)2.96640520
21Cerebral inclusion bodies (HP:0100314)2.92704306
22Cerebellar dysplasia (HP:0007033)2.90659153
23Poor eye contact (HP:0000817)2.87372866
24Anxiety (HP:0000739)2.86830745
25Fair hair (HP:0002286)2.86260755
26Truncal ataxia (HP:0002078)2.85299015
27Insidious onset (HP:0003587)2.83369942
28Termporal pattern (HP:0011008)2.83369942
29Neurofibrillary tangles (HP:0002185)2.75446590
30Depression (HP:0000716)2.74265990
31Limb dystonia (HP:0002451)2.71395143
32Progressive inability to walk (HP:0002505)2.68868911
33Dysmetria (HP:0001310)2.66680557
34Amblyopia (HP:0000646)2.65782534
35Impaired social interactions (HP:0000735)2.64500808
36Abnormal social behavior (HP:0012433)2.64500808
37Abnormal eating behavior (HP:0100738)2.63767739
38Epileptiform EEG discharges (HP:0011182)2.62759390
39Spastic gait (HP:0002064)2.60653693
40Abnormality of the corticospinal tract (HP:0002492)2.59815881
41Hyperglycinemia (HP:0002154)2.59237725
42Hypothermia (HP:0002045)2.56594835
43Dysmetric saccades (HP:0000641)2.54631035
44Impaired vibration sensation in the lower limbs (HP:0002166)2.52892112
45EEG with generalized epileptiform discharges (HP:0011198)2.50667496
46Prolonged partial thromboplastin time (HP:0003645)2.49957235
47Gaze-evoked nystagmus (HP:0000640)2.46398236
48Pancreatic cysts (HP:0001737)2.46227702
49Scanning speech (HP:0002168)2.45889774
50Drooling (HP:0002307)2.45554658
51Excessive salivation (HP:0003781)2.45554658
52Abolished electroretinogram (ERG) (HP:0000550)2.43625343
53Gait imbalance (HP:0002141)2.43441710
54Protruding tongue (HP:0010808)2.39652867
55Hypsarrhythmia (HP:0002521)2.35314248
56Dysdiadochokinesis (HP:0002075)2.34172581
57Abnormality of the renal cortex (HP:0011035)2.31459082
58Abnormal hair whorl (HP:0010721)2.31373600
59Generalized hypopigmentation of hair (HP:0011358)2.29373784
60Failure to thrive in infancy (HP:0001531)2.27245675
61Degeneration of the lateral corticospinal tracts (HP:0002314)2.27202130
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.27202130
63Polyphagia (HP:0002591)2.27182383
64Mutism (HP:0002300)2.26569568
65Lower limb muscle weakness (HP:0007340)2.24833323
66Hypoventilation (HP:0002791)2.23746796
67Retinal atrophy (HP:0001105)2.21846094
68Proximal tubulopathy (HP:0000114)2.21724493
69True hermaphroditism (HP:0010459)2.20356393
70Urinary bladder sphincter dysfunction (HP:0002839)2.19878084
71Urinary urgency (HP:0000012)2.19786618
72Abnormality of binocular vision (HP:0011514)2.19611409
73Diplopia (HP:0000651)2.19611409
74Postural instability (HP:0002172)2.19125682
75Epidermoid cyst (HP:0200040)2.18826511
76Abnormal biliary tract physiology (HP:0012439)2.17897293
77Bile duct proliferation (HP:0001408)2.17897293
78Nephronophthisis (HP:0000090)2.16772499
79Torticollis (HP:0000473)2.15874161
80Intrahepatic cholestasis (HP:0001406)2.15498048
81Tubulointerstitial nephritis (HP:0001970)2.13742877
82Inability to walk (HP:0002540)2.12772877
83Hypobetalipoproteinemia (HP:0003563)2.11533731
84Abnormality of the lower motor neuron (HP:0002366)2.10678942
85Pancreatic fibrosis (HP:0100732)2.09279095
86Renal cortical cysts (HP:0000803)2.08390299
87Abnormal pancreas size (HP:0012094)2.07543521
88Abnormality of glycine metabolism (HP:0010895)2.06630585
89Abnormality of serine family amino acid metabolism (HP:0010894)2.06630585
90Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.05832566
91Bradykinesia (HP:0002067)2.04957175
92Medial flaring of the eyebrow (HP:0010747)2.04636091
93Abnormal drinking behavior (HP:0030082)2.04354558
94Polydipsia (HP:0001959)2.04354558
95Focal dystonia (HP:0004373)2.04050805
96Widely spaced teeth (HP:0000687)2.03670692
97Delusions (HP:0000746)2.03329209
98Abnormality of the renal medulla (HP:0100957)2.02301300
99Congenital primary aphakia (HP:0007707)2.01590275
100Decreased circulating renin level (HP:0003351)2.01542726
101Specific learning disability (HP:0001328)2.01498443
102Cupped ear (HP:0000378)2.00902206
103Abnormality of monocarboxylic acid metabolism (HP:0010996)1.99667660
104Psychosis (HP:0000709)1.99577793
105Neoplasm of the peripheral nervous system (HP:0100007)1.99261529
106Hemiparesis (HP:0001269)1.98476010
107Ketosis (HP:0001946)1.98039298
108Poor coordination (HP:0002370)1.98033658
109Acute necrotizing encephalopathy (HP:0006965)1.97693063
110Absent speech (HP:0001344)1.97294420
111Megalencephaly (HP:0001355)1.97011822
112Retinal dysplasia (HP:0007973)1.95571510
113Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94757784
114Abnormality of alanine metabolism (HP:0010916)1.94757784
115Hyperalaninemia (HP:0003348)1.94757784
116Calf muscle hypertrophy (HP:0008981)1.94350988
117Resting tremor (HP:0002322)1.93734339
118Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.93398118
119Gonadotropin excess (HP:0000837)1.91499815
120Generalized myoclonic seizures (HP:0002123)1.91289770
121Akinesia (HP:0002304)1.90921185
122Male pseudohermaphroditism (HP:0000037)1.90704774
123Clumsiness (HP:0002312)1.89924426
124Stereotypic behavior (HP:0000733)1.89913064
125Craniofacial dystonia (HP:0012179)1.89246693
126Hypoplasia of the pons (HP:0012110)1.88040370
127Abnormal mitochondria in muscle tissue (HP:0008316)1.86303405
128Lower limb hyperreflexia (HP:0002395)1.85980496
129Abnormality of the pons (HP:0007361)1.84997728
130Nephrogenic diabetes insipidus (HP:0009806)1.84796921
131Hyperglycinuria (HP:0003108)1.84273593
132Aplasia/Hypoplasia of the tibia (HP:0005772)1.84255015
133Rapidly progressive (HP:0003678)1.83911612
134Abnormality of midbrain morphology (HP:0002418)1.83549958
135Molar tooth sign on MRI (HP:0002419)1.83549958
136Hyperkalemia (HP:0002153)1.83027044
137Thickened helices (HP:0000391)1.82292131
138Tubular atrophy (HP:0000092)1.82272549
139Fetal akinesia sequence (HP:0001989)1.82161920
140Hyperthyroidism (HP:0000836)1.81999432
141Peripheral hypomyelination (HP:0007182)1.81249269
142Abnormality of the axillary hair (HP:0100134)1.80664376
143Abnormality of secondary sexual hair (HP:0009888)1.80664376
144Clonus (HP:0002169)1.80560234
145Gait ataxia (HP:0002066)1.80526168
146Blue irides (HP:0000635)1.80216698
147Progressive macrocephaly (HP:0004481)1.79401223
148Genetic anticipation (HP:0003743)1.78602079
149Enlarged kidneys (HP:0000105)1.77851311
150Ketoacidosis (HP:0001993)1.77631992
151Agitation (HP:0000713)1.77614920
152Syncope (HP:0001279)1.77528500
153Congenital sensorineural hearing impairment (HP:0008527)1.77515716
154Methylmalonic acidemia (HP:0002912)1.77134369
155Vaginal atresia (HP:0000148)1.77057603
156Hepatoblastoma (HP:0002884)1.76543325
157Facial shape deformation (HP:0011334)1.75637117
158Potter facies (HP:0002009)1.75637117
159Absent eyebrow (HP:0002223)1.75420375
160Genital tract atresia (HP:0001827)1.74500906
161Impaired smooth pursuit (HP:0007772)1.73648209
162Sensory axonal neuropathy (HP:0003390)1.73255092
163Abnormality of serum amino acid levels (HP:0003112)1.73142828
164Large for gestational age (HP:0001520)1.72549169
165Intention tremor (HP:0002080)1.72129858
166Papillary thyroid carcinoma (HP:0002895)1.71960874
167Poor suck (HP:0002033)1.71526839

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.18806710
2EPHA43.47349204
3MAP3K43.29518632
4MAP3K93.18904306
5CASK3.12245908
6PINK13.10822588
7MARK13.07475968
8MAP2K72.69815771
9ARAF2.55139428
10MAP3K122.54256414
11STK38L2.51815276
12MINK12.41472845
13KSR21.96143846
14ACVR1B1.94927243
15DAPK21.91524264
16PLK21.89959983
17MAP4K21.77045715
18NTRK11.75246971
19LATS11.73741834
20MAP2K41.73602453
21CDK191.72479668
22PAK61.71485895
23NTRK21.67631788
24PNCK1.64278777
25GRK51.60425006
26KSR11.53390284
27CDK51.51796762
28PRPF4B1.51037269
29NLK1.48656469
30DAPK11.46763711
31OXSR11.46668798
32MAPK131.42805766
33TAOK31.40555437
34PRKD31.39306527
35MAP3K21.38410874
36RIPK41.33113497
37CAMK1G1.24519373
38OBSCN1.17627212
39UHMK11.16750904
40NUAK11.15618712
41MKNK21.14388964
42CAMK2A1.13987252
43CSNK1A1L1.09547897
44GRK11.07352598
45FGFR21.07141769
46MAP3K131.06995282
47PRKCG1.06451388
48CAMK2B1.06316851
49BCR1.06228548
50CDK141.05145200
51NME11.03505618
52CDK181.02971650
53TNIK1.02691960
54PTK2B1.02538333
55CDK150.98780216
56MARK30.98741110
57PAK30.97634286
58SGK4940.96854356
59SGK2230.96854356
60CSNK1G10.96755070
61CAMKK10.95311094
62STK390.94047213
63SIK20.93907486
64BRAF0.93825735
65TYRO30.93311131
66BMPR20.92797521
67CAMK1D0.92308687
68FGR0.88823609
69SGK30.88376448
70CDK11A0.84735640
71CDK30.84611881
72EIF2AK30.84101944
73CSNK1G20.83820988
74FES0.83328795
75LIMK10.83225997
76PHKG10.81131329
77PHKG20.81131329
78PIK3CA0.80843423
79EPHA30.79504726
80PRKCE0.79082567
81CAMK2D0.78944082
82DYRK1A0.78608493
83FER0.75452807
84CAMKK20.74932236
85STK240.74670797
86LATS20.73892025
87RET0.73558259
88LMTK20.72361557
89AKT30.71868417
90BRD40.71435654
91CCNB10.71159783
92MAP3K70.70551146
93MAPK150.69907021
94INSRR0.69850146
95TAOK10.69832578
96PRKAA20.69427072
97PRKCH0.68739073
98RAF10.68708887
99WNK40.66348518
100MARK20.64677029
101PRKAA10.63269044
102SIK30.61166948
103STK110.58683747
104MAP2K10.57809878
105CSNK1G30.57486693
106FGFR30.57409081
107DDR20.57317101
108WNK30.56910158
109CAMK2G0.56200419
110ROCK20.56031941
111STK30.55887738
112RPS6KB10.55566206
113DAPK30.53266538
114MYLK0.52975408
115MAP3K10.51903858
116STK380.51372564
117CAMK40.51257611
118NEK60.49386399
119SGK10.48486460
120TRIM280.48190039
121ADRBK10.48080006
122YES10.47794727
123PKN10.47783307
124CAMK10.46640577
125CSNK1D0.46530971
126FYN0.46310542
127CSNK1A10.45791815
128SGK20.44707489
129TNK20.44447792
130ZAK0.43696258
131ERBB30.43653972
132DMPK0.43553068
133PRKG10.43415627
134TSSK60.42642575
135IRAK10.42588094
136PDPK10.42538737
137MAPKAPK50.42066138
138BMPR1B0.41853718
139MOS0.41359886
140BRSK20.41166737
141DYRK20.38933579
142WNK10.38903884
143TIE10.38798678
144RPS6KA30.37741221
145PRKCZ0.36341863
146ADRBK20.36157474
147FRK0.35084784
148TRPM70.34693041

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.50951233
2Nicotine addiction_Homo sapiens_hsa050333.41735505
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.22748743
4GABAergic synapse_Homo sapiens_hsa047272.70234781
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70170010
6Olfactory transduction_Homo sapiens_hsa047402.63314676
7Collecting duct acid secretion_Homo sapiens_hsa049662.54591151
8Morphine addiction_Homo sapiens_hsa050322.51501150
9Circadian entrainment_Homo sapiens_hsa047132.49368503
10Steroid hormone biosynthesis_Homo sapiens_hsa001402.42544758
11Long-term potentiation_Homo sapiens_hsa047202.32583289
12Glutamatergic synapse_Homo sapiens_hsa047242.31099395
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.25551658
14Dopaminergic synapse_Homo sapiens_hsa047282.22425644
15Amphetamine addiction_Homo sapiens_hsa050312.21260823
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.10186509
17Caffeine metabolism_Homo sapiens_hsa002322.09882816
18Retinol metabolism_Homo sapiens_hsa008302.06268968
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96403183
20Insulin secretion_Homo sapiens_hsa049111.94400935
21Serotonergic synapse_Homo sapiens_hsa047261.93658789
22Vibrio cholerae infection_Homo sapiens_hsa051101.90817557
23Salivary secretion_Homo sapiens_hsa049701.89277549
24Cholinergic synapse_Homo sapiens_hsa047251.88651050
25Taste transduction_Homo sapiens_hsa047421.88139900
26Propanoate metabolism_Homo sapiens_hsa006401.87334784
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.84756939
28Circadian rhythm_Homo sapiens_hsa047101.83195185
29Histidine metabolism_Homo sapiens_hsa003401.80659487
30Tryptophan metabolism_Homo sapiens_hsa003801.79163857
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73777646
32Linoleic acid metabolism_Homo sapiens_hsa005911.72372268
33Cocaine addiction_Homo sapiens_hsa050301.69765090
34Renin secretion_Homo sapiens_hsa049241.67986037
35Long-term depression_Homo sapiens_hsa047301.67474122
36Gastric acid secretion_Homo sapiens_hsa049711.66248734
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.63086270
38Chemical carcinogenesis_Homo sapiens_hsa052041.60522652
39Oxidative phosphorylation_Homo sapiens_hsa001901.58354204
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.54103326
41Fatty acid biosynthesis_Homo sapiens_hsa000611.46692823
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.45434892
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.44102704
44ABC transporters_Homo sapiens_hsa020101.42759387
45Fatty acid degradation_Homo sapiens_hsa000711.42601056
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.42084390
47Oxytocin signaling pathway_Homo sapiens_hsa049211.41860897
48beta-Alanine metabolism_Homo sapiens_hsa004101.38238373
49Complement and coagulation cascades_Homo sapiens_hsa046101.35279103
50Calcium signaling pathway_Homo sapiens_hsa040201.34642195
51Gap junction_Homo sapiens_hsa045401.31469663
52GnRH signaling pathway_Homo sapiens_hsa049121.29345238
53Nitrogen metabolism_Homo sapiens_hsa009101.29247064
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26799937
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26659537
56Parkinsons disease_Homo sapiens_hsa050121.24526228
57Alzheimers disease_Homo sapiens_hsa050101.23912519
58Bile secretion_Homo sapiens_hsa049761.22635314
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22113363
60Axon guidance_Homo sapiens_hsa043601.21927149
61Cardiac muscle contraction_Homo sapiens_hsa042601.21784669
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.19912608
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19197809
64Arginine biosynthesis_Homo sapiens_hsa002201.19184214
65Peroxisome_Homo sapiens_hsa041461.18911322
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14379490
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12968053
68Phototransduction_Homo sapiens_hsa047441.05621397
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03902275
70Lysine degradation_Homo sapiens_hsa003101.03734747
71Ether lipid metabolism_Homo sapiens_hsa005651.01315327
72Glycerolipid metabolism_Homo sapiens_hsa005611.00985559
73cAMP signaling pathway_Homo sapiens_hsa040240.99917208
74Estrogen signaling pathway_Homo sapiens_hsa049150.99013201
75Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96372993
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.93349707
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93182869
78Type II diabetes mellitus_Homo sapiens_hsa049300.91611552
79ErbB signaling pathway_Homo sapiens_hsa040120.91218846
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90129023
81Glioma_Homo sapiens_hsa052140.89513787
82Melanogenesis_Homo sapiens_hsa049160.89437203
83Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87329178
84Fatty acid metabolism_Homo sapiens_hsa012120.86633758
85PPAR signaling pathway_Homo sapiens_hsa033200.86044591
86Fat digestion and absorption_Homo sapiens_hsa049750.83067483
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.81489916
88Arginine and proline metabolism_Homo sapiens_hsa003300.80798292
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78074623
90Tyrosine metabolism_Homo sapiens_hsa003500.76856724
91Oocyte meiosis_Homo sapiens_hsa041140.76169998
92Arachidonic acid metabolism_Homo sapiens_hsa005900.75603847
93Cysteine and methionine metabolism_Homo sapiens_hsa002700.74033996
94Phenylalanine metabolism_Homo sapiens_hsa003600.73888388
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73660985
96Huntingtons disease_Homo sapiens_hsa050160.72732449
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72678620
98Pancreatic secretion_Homo sapiens_hsa049720.71663485
99Selenocompound metabolism_Homo sapiens_hsa004500.71627917
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.71023241
101Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.68397171
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67700700
103Thyroid hormone synthesis_Homo sapiens_hsa049180.67439557
104Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67158159
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66473344
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64725071
107Dilated cardiomyopathy_Homo sapiens_hsa054140.64425106
108Starch and sucrose metabolism_Homo sapiens_hsa005000.64235625
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64137196
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62594350
111Alcoholism_Homo sapiens_hsa050340.61520256
112Ras signaling pathway_Homo sapiens_hsa040140.60558046
113Vitamin digestion and absorption_Homo sapiens_hsa049770.60392848
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59795524
115Sphingolipid metabolism_Homo sapiens_hsa006000.59540590
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59522234
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.58510349
118MAPK signaling pathway_Homo sapiens_hsa040100.57661574
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56058356
120Rheumatoid arthritis_Homo sapiens_hsa053230.54043761
121Dorso-ventral axis formation_Homo sapiens_hsa043200.53019819
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52262236
123Choline metabolism in cancer_Homo sapiens_hsa052310.51784273
124Type I diabetes mellitus_Homo sapiens_hsa049400.50732862
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49157667
126Endocytosis_Homo sapiens_hsa041440.48933426
127VEGF signaling pathway_Homo sapiens_hsa043700.48014325
128Rap1 signaling pathway_Homo sapiens_hsa040150.47684419
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.47546749
130Steroid biosynthesis_Homo sapiens_hsa001000.46392521
131Phagosome_Homo sapiens_hsa041450.46191478
132Mineral absorption_Homo sapiens_hsa049780.45751022
133AMPK signaling pathway_Homo sapiens_hsa041520.45664723
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.45421478
135Renal cell carcinoma_Homo sapiens_hsa052110.44494916
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42900837
137Prion diseases_Homo sapiens_hsa050200.40671101
138Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40669222
139Inositol phosphate metabolism_Homo sapiens_hsa005620.39776274
140Tight junction_Homo sapiens_hsa045300.38252247
141Endometrial cancer_Homo sapiens_hsa052130.36229680
142Glucagon signaling pathway_Homo sapiens_hsa049220.35802429
143Ovarian steroidogenesis_Homo sapiens_hsa049130.35349434
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33871070
145Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31826228
146Sulfur metabolism_Homo sapiens_hsa009200.30684757
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30521333
148Colorectal cancer_Homo sapiens_hsa052100.30149692
149Butanoate metabolism_Homo sapiens_hsa006500.28133125
150Wnt signaling pathway_Homo sapiens_hsa043100.28013355
151Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.27576740
152mTOR signaling pathway_Homo sapiens_hsa041500.26714544

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