FBXO28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)6.97301364
2pore complex assembly (GO:0046931)5.86421328
3cellular protein complex localization (GO:0034629)4.88991954
4mitotic sister chromatid cohesion (GO:0007064)4.77985928
5COPI coating of Golgi vesicle (GO:0048205)4.52516475
6Golgi transport vesicle coating (GO:0048200)4.52516475
7protein complex localization (GO:0031503)4.49861441
8regulation of mitotic spindle organization (GO:0060236)4.46208736
9ribosome assembly (GO:0042255)4.07477399
10protein localization to endosome (GO:0036010)4.06708647
11protein localization to chromosome, centromeric region (GO:0071459)4.05278566
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.90258887
13regulation of spindle organization (GO:0090224)3.88854119
14paraxial mesoderm development (GO:0048339)3.81558566
15mitotic metaphase plate congression (GO:0007080)3.77716968
16protein localization to kinetochore (GO:0034501)3.62651490
17metaphase plate congression (GO:0051310)3.58779847
18DNA unwinding involved in DNA replication (GO:0006268)3.58220803
19mitotic sister chromatid segregation (GO:0000070)3.53996783
20desmosome organization (GO:0002934)3.49192178
21sister chromatid segregation (GO:0000819)3.47955877
22regulation of RNA export from nucleus (GO:0046831)3.41672452
23protein export from nucleus (GO:0006611)3.39548360
24cytoplasmic mRNA processing body assembly (GO:0033962)3.37998123
25mitotic nuclear envelope disassembly (GO:0007077)3.37058027
26nuclear envelope disassembly (GO:0051081)3.34683421
27membrane disassembly (GO:0030397)3.34683421
28establishment of integrated proviral latency (GO:0075713)3.29231709
29synaptic vesicle maturation (GO:0016188)3.27882814
30hemidesmosome assembly (GO:0031581)3.24634145
31establishment of chromosome localization (GO:0051303)3.18268196
32ventricular cardiac muscle cell development (GO:0055015)3.13265642
33positive regulation of chromosome segregation (GO:0051984)3.11074079
34regulation of protein export from nucleus (GO:0046825)3.10949745
35regulation of chromosome segregation (GO:0051983)3.10584135
36regulation of centriole replication (GO:0046599)3.09999148
37negative regulation of DNA repair (GO:0045738)3.06516665
38regulation of translational fidelity (GO:0006450)3.05785718
39nerve growth factor signaling pathway (GO:0038180)3.04122897
40double-strand break repair via nonhomologous end joining (GO:0006303)2.98491180
41non-recombinational repair (GO:0000726)2.98491180
42negative regulation of chromosome segregation (GO:0051985)2.98033860
43histone H2B ubiquitination (GO:0033523)2.96467873
44nuclear envelope organization (GO:0006998)2.94126958
45mitotic spindle checkpoint (GO:0071174)2.93861691
46spindle checkpoint (GO:0031577)2.92468061
47regulation of translational termination (GO:0006449)2.91863543
48axon ensheathment in central nervous system (GO:0032291)2.91570971
49central nervous system myelination (GO:0022010)2.91570971
50formation of translation preinitiation complex (GO:0001731)2.90985324
51negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90950235
52negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90950235
53negative regulation of mitotic sister chromatid separation (GO:2000816)2.90950235
54negative regulation of sister chromatid segregation (GO:0033046)2.90950235
55negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90950235
56regulation of clathrin-mediated endocytosis (GO:2000369)2.90005442
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.89970542
58regulation of mitotic metaphase/anaphase transition (GO:0030071)2.89970542
59regulation of mitotic sister chromatid separation (GO:0010965)2.88417763
60regulation of mitotic sister chromatid segregation (GO:0033047)2.88417763
61regulation of sister chromatid segregation (GO:0033045)2.88417763
62mitotic spindle assembly checkpoint (GO:0007094)2.87354407
63regulation of female gonad development (GO:2000194)2.87011892
64DNA duplex unwinding (GO:0032508)2.86038404
65regulation of early endosome to late endosome transport (GO:2000641)2.85400174
66negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.85354537
67positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.84697572
68spindle assembly checkpoint (GO:0071173)2.79482517
69cellular response to nerve growth factor stimulus (GO:1990090)2.77515323
70response to nerve growth factor (GO:1990089)2.77515323
71protein destabilization (GO:0031648)2.77061498
72protein localization to microtubule (GO:0035372)2.76843704
73layer formation in cerebral cortex (GO:0021819)2.74840363
74cytoskeleton-dependent cytokinesis (GO:0061640)2.73066338
75DNA geometric change (GO:0032392)2.72667343
76embryonic process involved in female pregnancy (GO:0060136)2.72440613
77COPII vesicle coating (GO:0048208)2.68572862
78somatic stem cell division (GO:0048103)2.68239117
79asymmetric protein localization (GO:0008105)2.68204838
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.67814274
81mitochondrial DNA metabolic process (GO:0032042)2.66385249
82positive regulation of mitotic sister chromatid separation (GO:1901970)2.66008988
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66008988
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66008988
85apical protein localization (GO:0045176)2.65935276
86negative regulation of fibroblast apoptotic process (GO:2000270)2.64057624
87vesicle coating (GO:0006901)2.63277401
88spliceosomal tri-snRNP complex assembly (GO:0000244)2.62710471
89membrane budding (GO:0006900)2.60179700
90regulation of DNA endoreduplication (GO:0032875)2.58870401
91DNA strand elongation (GO:0022616)2.57804570
92positive regulation of protein export from nucleus (GO:0046827)2.57089347
93sodium ion export (GO:0071436)2.56942790
94positive regulation of cell cycle checkpoint (GO:1901978)2.54569396
95DNA strand elongation involved in DNA replication (GO:0006271)2.53311356
96establishment of nucleus localization (GO:0040023)2.51665767
97nucleobase-containing small molecule interconversion (GO:0015949)2.50543417
98chromosome condensation (GO:0030261)2.49957514
99bundle of His cell to Purkinje myocyte communication (GO:0086069)2.49772236
100dosage compensation (GO:0007549)2.46933231
101DNA packaging (GO:0006323)2.46697111
102localization within membrane (GO:0051668)2.46248160
103mammary gland epithelial cell proliferation (GO:0033598)2.44599518
104DNA conformation change (GO:0071103)2.42997484
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41991672
106locomotory exploration behavior (GO:0035641)2.40671192
107platelet-derived growth factor receptor signaling pathway (GO:0048008)2.40386135
108mitotic cytokinesis (GO:0000281)2.39910236
109DNA replication initiation (GO:0006270)2.38735111
110nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.37554576
111adherens junction assembly (GO:0034333)2.37552712
112cell-substrate junction assembly (GO:0007044)2.36936274
113dendrite morphogenesis (GO:0048813)2.36416095
114histone H2A monoubiquitination (GO:0035518)2.35972647
115microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.35547676
116hippo signaling (GO:0035329)2.35322793
117ribosome biogenesis (GO:0042254)2.35303716
118regulation of transforming growth factor beta2 production (GO:0032909)2.34994374
119clathrin coat assembly (GO:0048268)2.30210002
120corticosteroid receptor signaling pathway (GO:0031958)2.29529014
121cell adhesion mediated by integrin (GO:0033627)2.28436093
122negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.27368649
123cortical actin cytoskeleton organization (GO:0030866)2.26933201
124lens fiber cell development (GO:0070307)2.23196325
125epithelial cell fate commitment (GO:0072148)2.22476021
126cellular potassium ion homeostasis (GO:0030007)2.21380120
127mesodermal cell differentiation (GO:0048333)2.20495929
128growth hormone receptor signaling pathway (GO:0060396)2.20212723
129cerebral cortex radially oriented cell migration (GO:0021799)2.17191833
130lens morphogenesis in camera-type eye (GO:0002089)2.15070989
131stress fiber assembly (GO:0043149)2.14123267
132protein targeting to plasma membrane (GO:0072661)2.12487383
133regulation of sister chromatid cohesion (GO:0007063)2.12139149
134positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.09277659
135stem cell division (GO:0017145)2.08888269
136cortical cytoskeleton organization (GO:0030865)2.08564084
137chondrocyte proliferation (GO:0035988)2.07183606
138type B pancreatic cell development (GO:0003323)2.06547976
139regulation of synaptic vesicle exocytosis (GO:2000300)2.03486704
140glucocorticoid receptor signaling pathway (GO:0042921)2.01213646
141female gamete generation (GO:0007292)2.00712093
142membrane raft organization (GO:0031579)2.00652059
143NLS-bearing protein import into nucleus (GO:0006607)1.96819204
144Rap protein signal transduction (GO:0032486)1.95752681
145peptidyl-threonine phosphorylation (GO:0018107)1.95460603
146ensheathment of neurons (GO:0007272)1.93902147
147axon ensheathment (GO:0008366)1.93902147
148regulation of ARF protein signal transduction (GO:0032012)1.93770754
149peptidyl-threonine modification (GO:0018210)1.93647712
150myelination (GO:0042552)1.92759675
151negative regulation of neurotransmitter secretion (GO:0046929)1.91942259
152negative regulation of hormone metabolic process (GO:0032351)1.90603573
153negative regulation of hormone biosynthetic process (GO:0032353)1.90603573
154regulation of ARF GTPase activity (GO:0032312)1.89900971
155establishment of spindle localization (GO:0051293)1.89770995
156synaptic vesicle exocytosis (GO:0016079)1.89414934
157negative regulation of smooth muscle cell differentiation (GO:0051151)1.89364338
158cell migration in hindbrain (GO:0021535)1.88336652
159nuclear pore complex assembly (GO:0051292)1.88220741
160pre-miRNA processing (GO:0031054)1.87839136
161photoreceptor cell differentiation (GO:0046530)1.87059205
162eye photoreceptor cell differentiation (GO:0001754)1.87059205
163regulation of homotypic cell-cell adhesion (GO:0034110)1.86953550
164establishment or maintenance of bipolar cell polarity (GO:0061245)1.85427485
165establishment or maintenance of apical/basal cell polarity (GO:0035088)1.85427485
166positive regulation of microtubule polymerization (GO:0031116)1.85340527
167glutamate secretion (GO:0014047)1.84853960
168piRNA metabolic process (GO:0034587)1.84019232
169regulation of neuron migration (GO:2001222)1.83769035
170regulation of short-term neuronal synaptic plasticity (GO:0048172)1.83644238
171notochord development (GO:0030903)1.81701934
172negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.81449372
173establishment of endothelial barrier (GO:0061028)1.81130267
174activation of JUN kinase activity (GO:0007257)1.81056745
175gene silencing by RNA (GO:0031047)1.80784019
176positive regulation of establishment of protein localization to plasma membrane (GO:0090004)1.80294841
177regulation of nucleobase-containing compound transport (GO:0032239)1.79600139
178regulation of meiosis (GO:0040020)1.78910017
179embryonic body morphogenesis (GO:0010172)1.78583965
180mitotic chromosome condensation (GO:0007076)1.78243561
181peripheral nervous system axon ensheathment (GO:0032292)1.77895779
182myelination in peripheral nervous system (GO:0022011)1.77895779
183positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)1.77869427
184nucleus localization (GO:0051647)1.76919480
185activation of protein kinase A activity (GO:0034199)1.75229323
186negative regulation of organelle assembly (GO:1902116)1.74708302
187inactivation of MAPK activity (GO:0000188)1.74615822
188activation of MAPKK activity (GO:0000186)1.74539947
189fibroblast migration (GO:0010761)1.74063233
190regulation of somitogenesis (GO:0014807)1.73548619

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02292005
2AR_21909140_ChIP-Seq_LNCAP_Human3.96619051
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.18532842
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08420917
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.01023276
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.91937717
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90477288
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.83583877
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.82266429
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78301163
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65983851
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.60627488
13TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.48506519
14PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.33572294
15ZNF263_19887448_ChIP-Seq_K562_Human2.30092257
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26012748
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17323515
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.15752995
19ZFX_18555785_ChIP-Seq_MESCs_Mouse2.14411581
20EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.12160883
21MYCN_18555785_ChIP-Seq_MESCs_Mouse2.09388409
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.08637452
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07670187
24FOXO3_23340844_ChIP-Seq_DLD1_Human2.06903271
25ZNF217_24962896_ChIP-Seq_MCF-7_Human2.06779749
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06604302
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.99704016
28MYC_19030024_ChIP-ChIP_MESCs_Mouse1.96812599
29SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.92122365
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91418808
31FOXM1_23109430_ChIP-Seq_U2OS_Human1.83844252
32CLOCK_20551151_ChIP-Seq_293T_Human1.83117329
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.81851927
34RBPJ_22232070_ChIP-Seq_NCS_Mouse1.80683342
35TP53_16413492_ChIP-PET_HCT116_Human1.80038285
36AR_21572438_ChIP-Seq_LNCaP_Human1.78380540
37TFEB_21752829_ChIP-Seq_HELA_Human1.78096407
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.77351137
39DCP1A_22483619_ChIP-Seq_HELA_Human1.76053743
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.73674476
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.73026414
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.72862474
43CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.69415900
44* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66076260
45* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64708821
46* CHD1_26751641_Chip-Seq_LNCaP_Human1.64487868
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.62076729
48* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.58812199
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.58528170
50WT1_19549856_ChIP-ChIP_CCG9911_Human1.58398606
51* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.57754890
52EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.52736623
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45593720
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.45345058
55* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45305274
56ELK1_19687146_ChIP-ChIP_HELA_Human1.45069358
57EP300_21415370_ChIP-Seq_HL-1_Mouse1.44967838
58EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43374027
59EZH2_22144423_ChIP-Seq_EOC_Human1.42276913
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.41376080
61* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.41328175
62GBX2_23144817_ChIP-Seq_PC3_Human1.41240053
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.40971455
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.40400296
65ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.39759943
66CJUN_26792858_Chip-Seq_BT549_Human1.37945443
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37850902
68XRN2_22483619_ChIP-Seq_HELA_Human1.35126345
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33852447
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33755153
71ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.33520479
72KDM2B_26808549_Chip-Seq_K562_Human1.33428920
73RXR_22108803_ChIP-Seq_LS180_Human1.33013949
74* SOX17_20123909_ChIP-Seq_XEN_Mouse1.32170306
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.31307132
76RUNX_20019798_ChIP-Seq_JUKART_Human1.31212662
77CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.28763039
78BRD4_25478319_ChIP-Seq_HGPS_Human1.28540251
79ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27623262
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.27224496
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27176384
82ESR1_20079471_ChIP-ChIP_T-47D_Human1.27113242
83PKCTHETA_26484144_Chip-Seq_BREAST_Human1.26931306
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26536515
85* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26458256
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.26278138
87ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25160215
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23454633
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23454633
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22918877
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22379291
92JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22336201
93OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21156839
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20639532
95* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.20488895
96* TP63_23658742_ChIP-Seq_EP156T_Human1.20080050
97TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18309047
98KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17897330
99ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17777724
100KDM2B_26808549_Chip-Seq_DND41_Human1.17149507
101P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17038649
102* KDM5A_27292631_Chip-Seq_BREAST_Human1.16883618
103POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16882812
104TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.16860478
105* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15667911
106* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.15446511
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14923229
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.14780607
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13632172
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13312369
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12771335
112* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.11946443
113ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11629700
114KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09954926
115RNF2_27304074_Chip-Seq_ESCs_Mouse1.09677968
116* TTF2_22483619_ChIP-Seq_HELA_Human1.09313587
117MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08094431
118MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07876149
119CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07815786
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07557572
121SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07557572
122* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07520638
123TCF4_18268006_ChIP-ChIP_LS174T_Human1.06595241
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06208471
125SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06048118
126* STAT3_23295773_ChIP-Seq_U87_Human1.05727319
127EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05213652
128NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04782914
129* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03971385
130YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03925819
131SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03217310
132STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02963150
133TP53_18474530_ChIP-ChIP_U2OS_Human1.02783941
134NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02502758
135NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02502758
136SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.02245076
137NFIB_24661679_ChIP-Seq_LUNG_Mouse1.02150584
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.02046872
139NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01964439
140SMAD4_21799915_ChIP-Seq_A2780_Human1.01943678
141* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01907524
142ATF3_27146783_Chip-Seq_COLON_Human1.01526582
143NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01455291
144TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00490285
145AHR_22903824_ChIP-Seq_MCF-7_Human0.99979678
146SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99788979
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99787035
148ETS1_20019798_ChIP-Seq_JURKAT_Human0.98909127
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98905448
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98579535
151SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98198123
152PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.97655025
153GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97215081
154SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97055821
155SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96438694
156SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96315208
157DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96188444
158* PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95442556
159CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.95191865
160ELF5_23300383_ChIP-Seq_T47D_Human0.94781386
161UBF1/2_26484160_Chip-Seq_HMECs_Human0.94518743
162HIF1A_21447827_ChIP-Seq_MCF-7_Human0.94328522
163NANOG_21062744_ChIP-ChIP_HESCs_Human0.93955148
164* GABP_19822575_ChIP-Seq_HepG2_Human0.93835734
165* SMAD3_21741376_ChIP-Seq_EPCs_Human0.93438986
166SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93246550
167DROSHA_22980978_ChIP-Seq_HELA_Human0.92436889
168NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92349386
169* RARB_27405468_Chip-Seq_BRAIN_Mouse0.91675178
170SOX2_21211035_ChIP-Seq_LN229_Gbm0.90975976
171STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90278580
172* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89753482
173TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89640408
174BCAT_22108803_ChIP-Seq_LS180_Human0.89339507
175CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87514981
176TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86587415

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology3.09576856
2MP0008057_abnormal_DNA_replication3.08742936
3MP0010234_abnormal_vibrissa_follicle3.08401230
4MP0002877_abnormal_melanocyte_morpholog3.02622074
5MP0004957_abnormal_blastocyst_morpholog2.78291284
6MP0003111_abnormal_nucleus_morphology2.65345762
7MP0003077_abnormal_cell_cycle2.55927775
8MP0004859_abnormal_synaptic_plasticity2.48197166
9MP0004270_analgesia2.36398132
10MP0010094_abnormal_chromosome_stability2.32344954
11MP0003693_abnormal_embryo_hatching2.29535885
12MP0001299_abnormal_eye_distance/2.24513445
13MP0002009_preneoplasia2.24507049
14MP0003941_abnormal_skin_development2.19540678
15MP0005451_abnormal_body_composition2.15696412
16MP0009780_abnormal_chondrocyte_physiolo2.08435414
17MP0000569_abnormal_digit_pigmentation2.07699683
18MP0003880_abnormal_central_pattern2.06892826
19MP0003091_abnormal_cell_migration2.06612827
20MP0004185_abnormal_adipocyte_glucose1.99103445
21MP0010678_abnormal_skin_adnexa1.87981290
22MP0003705_abnormal_hypodermis_morpholog1.87897667
23MP0009697_abnormal_copulation1.86193684
24MP0003221_abnormal_cardiomyocyte_apopto1.84607475
25MP0005423_abnormal_somatic_nervous1.79673009
26MP0005501_abnormal_skin_physiology1.77447270
27MP0003191_abnormal_cellular_cholesterol1.73917196
28MP0008007_abnormal_cellular_replicative1.73565963
29MP0000537_abnormal_urethra_morphology1.71491592
30MP0005275_abnormal_skin_tensile1.62414887
31MP0004885_abnormal_endolymph1.61140666
32MP0003950_abnormal_plasma_membrane1.60451857
33MP0000733_abnormal_muscle_development1.59049007
34MP0005367_renal/urinary_system_phenotyp1.58071743
35MP0000516_abnormal_urinary_system1.58071743
36MP0001672_abnormal_embryogenesis/_devel1.57069172
37MP0005380_embryogenesis_phenotype1.57069172
38MP0000920_abnormal_myelination1.55921614
39MP0010352_gastrointestinal_tract_polyps1.50849822
40MP0005409_darkened_coat_color1.49567603
41MP0008058_abnormal_DNA_repair1.48076421
42MP0003984_embryonic_growth_retardation1.47908256
43MP0003453_abnormal_keratinocyte_physiol1.44903800
44MP0002060_abnormal_skin_morphology1.42674521
45MP0006054_spinal_hemorrhage1.41839975
46MP0002088_abnormal_embryonic_growth/wei1.41461668
47MP0004272_abnormal_basement_membrane1.38648825
48MP0002006_tumorigenesis1.31157517
49MP0008260_abnormal_autophagy1.30915997
50MP0008438_abnormal_cutaneous_collagen1.29077238
51MP0001216_abnormal_epidermal_layer1.29008577
52MP0000383_abnormal_hair_follicle1.26973817
53MP0002080_prenatal_lethality1.25922773
54MP0000579_abnormal_nail_morphology1.25084813
55MP0010368_abnormal_lymphatic_system1.24063104
56MP0003566_abnormal_cell_adhesion1.23636863
57MP0001915_intracranial_hemorrhage1.22534385
58MP0004197_abnormal_fetal_growth/weight/1.21044121
59MP0009053_abnormal_anal_canal1.19700862
60MP0001188_hyperpigmentation1.18426246
61MP0003635_abnormal_synaptic_transmissio1.18310170
62MP0003806_abnormal_nucleotide_metabolis1.18188623
63MP0003828_pulmonary_edema1.17796762
64MP0000778_abnormal_nervous_system1.17763742
65MP0000566_synostosis1.16848448
66MP0002697_abnormal_eye_size1.15588661
67MP0010030_abnormal_orbit_morphology1.13889835
68MP0005621_abnormal_cell_physiology1.13547632
69MP0001661_extended_life_span1.12197700
70MP0001348_abnormal_lacrimal_gland1.10779615
71MP0010307_abnormal_tumor_latency1.10537810
72MP0004858_abnormal_nervous_system1.09153254
73MP0001958_emphysema1.08934501
74MP0005076_abnormal_cell_differentiation1.05293169
75MP0003755_abnormal_palate_morphology1.04573043
76MP0000647_abnormal_sebaceous_gland1.04232681
77MP0002734_abnormal_mechanical_nocicepti1.04218132
78MP0005257_abnormal_intraocular_pressure1.04054386
79MP0000627_abnormal_mammary_gland1.02613940
80MP0002084_abnormal_developmental_patter1.02424859
81MP0003634_abnormal_glial_cell1.01724552
82MP0003385_abnormal_body_wall1.01294802
83MP0004782_abnormal_surfactant_physiolog0.98191144
84MP0000377_abnormal_hair_follicle0.96657200
85MP0002092_abnormal_eye_morphology0.96286665
86MP0003045_fibrosis0.95956871
87MP0003937_abnormal_limbs/digits/tail_de0.95178123
88MP0002269_muscular_atrophy0.94801830
89MP0004808_abnormal_hematopoietic_stem0.92799300
90MP0001346_abnormal_lacrimal_gland0.92186917
91MP0005310_abnormal_salivary_gland0.91400857
92MP0005187_abnormal_penis_morphology0.90784321
93MP0009250_abnormal_appendicular_skeleto0.90534628
94MP0002925_abnormal_cardiovascular_devel0.90367543
95MP0005384_cellular_phenotype0.90068219
96MP0002177_abnormal_outer_ear0.90045608
97MP0003656_abnormal_erythrocyte_physiolo0.89966713
98MP0002098_abnormal_vibrissa_morphology0.89855707
99MP0002184_abnormal_innervation0.89357297
100MP0002166_altered_tumor_susceptibility0.88523322
101MP0003787_abnormal_imprinting0.87756588
102MP0003890_abnormal_embryonic-extraembry0.87260503
103MP0009672_abnormal_birth_weight0.86827910
104MP0004264_abnormal_extraembryonic_tissu0.86732548
105MP0003303_peritoneal_inflammation0.86242111
106MP0001727_abnormal_embryo_implantation0.86145046
107MP0003448_altered_tumor_morphology0.86100680
108MP0000762_abnormal_tongue_morphology0.85433002
109MP0000313_abnormal_cell_death0.85159488
110MP0004484_altered_response_of0.84488840
111MP0008775_abnormal_heart_ventricle0.84426976
112MP0005197_abnormal_uvea_morphology0.84426965
113MP0004510_myositis0.84281374
114MP0008569_lethality_at_weaning0.84227250
115MP0001849_ear_inflammation0.82713178
116MP0005408_hypopigmentation0.82626635
117MP0000955_abnormal_spinal_cord0.81758091
118MP0004134_abnormal_chest_morphology0.81062770
119MP0002796_impaired_skin_barrier0.80866487
120MP0005248_abnormal_Harderian_gland0.77996175
121MP0003632_abnormal_nervous_system0.77624511
122MP0000858_altered_metastatic_potential0.76845489
123MP0010771_integument_phenotype0.76529477
124MP0005508_abnormal_skeleton_morphology0.75844555
125MP0003718_maternal_effect0.75683389
126MP0005023_abnormal_wound_healing0.75204509
127MP0000490_abnormal_crypts_of0.73674933
128MP0003300_gastrointestinal_ulcer0.73281553
129MP0008932_abnormal_embryonic_tissue0.72990020
130MP0001191_abnormal_skin_condition0.72824968
131MP0000015_abnormal_ear_pigmentation0.72791740
132MP0004947_skin_inflammation0.72313984
133MP0000428_abnormal_craniofacial_morphol0.71717186
134MP0000749_muscle_degeneration0.71671759
135MP0002085_abnormal_embryonic_tissue0.69990106
136MP0000350_abnormal_cell_proliferation0.69969890
137MP0000747_muscle_weakness0.69498967
138MP0006138_congestive_heart_failure0.69491659
139MP0001784_abnormal_fluid_regulation0.68946713
140MP0000534_abnormal_ureter_morphology0.68704533
141MP0003861_abnormal_nervous_system0.68233228
142MP0001730_embryonic_growth_arrest0.67791679
143MP0004811_abnormal_neuron_physiology0.65986948
144MP0005171_absent_coat_pigmentation0.65965803
145MP0003935_abnormal_craniofacial_develop0.65703237
146MP0002295_abnormal_pulmonary_circulatio0.64453472
147MP0001851_eye_inflammation0.64186589
148MP0000467_abnormal_esophagus_morphology0.63850992
149MP0008004_abnormal_stomach_pH0.63710506
150MP0004084_abnormal_cardiac_muscle0.62432938
151MP0001697_abnormal_embryo_size0.61123885
152MP0002063_abnormal_learning/memory/cond0.60701985
153MP0002086_abnormal_extraembryonic_tissu0.60642525
154MP0004087_abnormal_muscle_fiber0.60590490
155MP0004233_abnormal_muscle_weight0.60289775
156MP0000767_abnormal_smooth_muscle0.60013285
157MP0001879_abnormal_lymphatic_vessel0.58828199
158MP0000432_abnormal_head_morphology0.58216535

Predicted human phenotypes

RankGene SetZ-score
1Aplasia involving bones of the extremities (HP:0009825)3.44240549
2Aplasia involving bones of the upper limbs (HP:0009823)3.44240549
3Aplasia of the phalanges of the hand (HP:0009802)3.44240549
4Selective tooth agenesis (HP:0001592)3.41299298
5Ankyloglossia (HP:0010296)3.25430831
6Shallow orbits (HP:0000586)3.10009227
7Megalencephaly (HP:0001355)2.95539018
8Cortical dysplasia (HP:0002539)2.77864622
9Papillary thyroid carcinoma (HP:0002895)2.75717161
10Right ventricular cardiomyopathy (HP:0011663)2.73957892
11Termporal pattern (HP:0011008)2.61657126
12Insidious onset (HP:0003587)2.61657126
13Deep philtrum (HP:0002002)2.55566198
14Abnormal foot bone ossification (HP:0010675)2.54325108
15Abnormality of oral frenula (HP:0000190)2.53790107
16Syringomyelia (HP:0003396)2.52358830
17Spinal cord lesions (HP:0100561)2.52358830
18Osteolytic defects of the hand bones (HP:0009699)2.52233936
19Osteolytic defects of the phalanges of the hand (HP:0009771)2.52233936
20Abnormality of the distal phalanges of the toes (HP:0010182)2.50531786
21Upper motor neuron abnormality (HP:0002127)2.40753596
22Arterial tortuosity (HP:0005116)2.39699778
23Abnormality of nail color (HP:0100643)2.39574988
24Coronal craniosynostosis (HP:0004440)2.39374388
25Deviation of the thumb (HP:0009603)2.38312134
26Abnormality of the phalanges of the hallux (HP:0010057)2.38037193
27Tetraparesis (HP:0002273)2.36676361
28Progressive external ophthalmoplegia (HP:0000590)2.36254936
29Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.35408835
30Aqueductal stenosis (HP:0002410)2.33468712
31Freckling (HP:0001480)2.26895090
32Onycholysis (HP:0001806)2.25754833
33Spastic diplegia (HP:0001264)2.24879010
34Alacrima (HP:0000522)2.23907364
35Flat acetabular roof (HP:0003180)2.23743340
36Abnormality of the middle phalanges of the toes (HP:0010183)2.22360780
37Degeneration of the lateral corticospinal tracts (HP:0002314)2.20566337
38Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20566337
39Septate vagina (HP:0001153)2.19772325
40Progressive muscle weakness (HP:0003323)2.17927456
41Abnormality of the corticospinal tract (HP:0002492)2.15624396
42Vascular tortuosity (HP:0004948)2.15086464
43Proximal placement of thumb (HP:0009623)2.11087533
44Protrusio acetabuli (HP:0003179)2.08857061
45Urinary urgency (HP:0000012)2.08129953
46Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.06876971
47Macroorchidism (HP:0000053)2.04654168
48Relative macrocephaly (HP:0004482)2.03439024
49Abnormal tarsal ossification (HP:0008369)2.03284230
50Male infertility (HP:0003251)2.03160996
51Malignant gastrointestinal tract tumors (HP:0006749)2.01538487
52Gastrointestinal carcinoma (HP:0002672)2.01538487
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.01161401
54Action tremor (HP:0002345)1.99423933
55Supranuclear gaze palsy (HP:0000605)1.96550688
56Autoamputation (HP:0001218)1.94275587
57Shoulder girdle muscle weakness (HP:0003547)1.91264656
58Heterotopia (HP:0002282)1.90552290
59Cerebral inclusion bodies (HP:0100314)1.90526783
60Abnormal auditory evoked potentials (HP:0006958)1.90242319
61Missing ribs (HP:0000921)1.89540155
62Abnormality of the salivary glands (HP:0010286)1.89142265
63Multiple enchondromatosis (HP:0005701)1.86759836
64Genetic anticipation (HP:0003743)1.86478355
65Sensory axonal neuropathy (HP:0003390)1.86363862
66Persistence of primary teeth (HP:0006335)1.85853118
67Neurofibrillary tangles (HP:0002185)1.85808411
68Premature rupture of membranes (HP:0001788)1.85265425
69Short nail (HP:0001799)1.83888522
70Scanning speech (HP:0002168)1.82396400
71Deviation of the hallux (HP:0010051)1.81241524
72Fragile nails (HP:0001808)1.80821351
73Chromsome breakage (HP:0040012)1.80506074
74Urinary bladder sphincter dysfunction (HP:0002839)1.80437448
75Hallux valgus (HP:0001822)1.80322965
76Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.79401433
77Short 4th metacarpal (HP:0010044)1.79241749
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79241749
79Apathy (HP:0000741)1.78966028
80Limited elbow extension (HP:0001377)1.78806387
81Genu recurvatum (HP:0002816)1.78247717
82Cerebral aneurysm (HP:0004944)1.77986256
83Dysmetric saccades (HP:0000641)1.77877480
84Exercise-induced muscle cramps (HP:0003710)1.77862137
85Entropion (HP:0000621)1.77411785
86Rhabdomyosarcoma (HP:0002859)1.76660181
87Renal cell carcinoma (HP:0005584)1.76522826
88Overlapping toe (HP:0001845)1.75033162
89Cubitus valgus (HP:0002967)1.73955814
90Overgrowth (HP:0001548)1.73442744
91Bladder neoplasm (HP:0009725)1.73239140
92Bladder carcinoma (HP:0002862)1.73239140
93Uterine neoplasm (HP:0010784)1.72759742
94Atrophic scars (HP:0001075)1.71760708
95Neonatal short-limb short stature (HP:0008921)1.71011582
96Abnormality of the lower motor neuron (HP:0002366)1.70873313
97Thickened helices (HP:0000391)1.70356898
98Sparse lateral eyebrow (HP:0005338)1.69386739
99Abnormality of the left ventricular outflow tract (HP:0011103)1.69124287
100Subaortic stenosis (HP:0001682)1.69124287
101Transitional cell carcinoma of the bladder (HP:0006740)1.68674444
102Reduced subcutaneous adipose tissue (HP:0003758)1.68493768
103Thick nail (HP:0001805)1.68385654
104Disinhibition (HP:0000734)1.68378174
105Thyroid carcinoma (HP:0002890)1.68308827
106Diminished motivation (HP:0000745)1.67975206
107Aortic aneurysm (HP:0004942)1.67737900
108Abnormal umbilical cord blood vessels (HP:0011403)1.67701407
109Single umbilical artery (HP:0001195)1.67701407
110Abnormality of the fetal cardiovascular system (HP:0010948)1.67701407
111Vertebral compression fractures (HP:0002953)1.67617921
112Trismus (HP:0000211)1.67534266
113Spondylolisthesis (HP:0003302)1.67437017
114Hypoplasia of the iris (HP:0007676)1.66839761
115Neoplasm of the small intestine (HP:0100833)1.66619659
116Natal tooth (HP:0000695)1.66005424
117Buphthalmos (HP:0000557)1.65585074
118Milia (HP:0001056)1.65574655
119Hyporeflexia of lower limbs (HP:0002600)1.65527377
120Chin dimple (HP:0010751)1.65415165
121Hammertoe (HP:0001765)1.65003224
122Scapular winging (HP:0003691)1.64942672
123Abnormality of the umbilical cord (HP:0010881)1.64876698
124Hyperextensible skin (HP:0000974)1.63772491
125Acute myeloid leukemia (HP:0004808)1.63555518
126Subacute progressive viral hepatitis (HP:0006572)1.63457647
127Narrow palate (HP:0000189)1.63228553
128Decreased lacrimation (HP:0000633)1.62476944
129Pelvic girdle muscle weakness (HP:0003749)1.62130047
130Abnormality of cochlea (HP:0000375)1.61903867
131Curly hair (HP:0002212)1.60796253
132Broad metatarsal (HP:0001783)1.60709176
133Medulloblastoma (HP:0002885)1.60332168
134Distal sensory impairment (HP:0002936)1.59619304
135Hematochezia (HP:0002573)1.59500429
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.58460449
137Papilledema (HP:0001085)1.57601321
138Upper limb amyotrophy (HP:0009129)1.56369137
139Distal upper limb amyotrophy (HP:0007149)1.56369137
140Plantar hyperkeratosis (HP:0007556)1.56297673
141Broad nasal tip (HP:0000455)1.56293038
142Abnormality of the astrocytes (HP:0100707)1.55462322
143Astrocytoma (HP:0009592)1.55462322
144Alopecia of scalp (HP:0002293)1.53749535
145Advanced eruption of teeth (HP:0006288)1.53633504
146Fatigue (HP:0012378)1.53479448
147Achilles tendon contracture (HP:0001771)1.53426907
148Microglossia (HP:0000171)1.53403722
149Lip pit (HP:0100267)1.51974952
150Spinal cord compression (HP:0002176)1.51918842
151Midline defect of the nose (HP:0004122)1.51735331
152Trigonocephaly (HP:0000243)1.51447886
153Vertebral arch anomaly (HP:0008438)1.51301188
154Stenosis of the external auditory canal (HP:0000402)1.50792695
155Intrahepatic cholestasis (HP:0001406)1.50764956
156Neoplasm of the colon (HP:0100273)1.49651904
157Intellectual disability, profound (HP:0002187)1.49576489
158Ankle contracture (HP:0006466)1.49108134
159Back pain (HP:0003418)1.48727795
160Atonic seizures (HP:0010819)1.47613885
161Deep palmar crease (HP:0006191)1.46424552
162Adactyly (HP:0009776)1.46229679
163Aplasia cutis congenita (HP:0001057)1.46134270
164Fibular aplasia (HP:0002990)1.44138707
165Radial bowing (HP:0002986)1.44135308
166Abnormality of the 4th metacarpal (HP:0010012)1.43904845
167Lower limb amyotrophy (HP:0007210)1.43689443
168Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.43127370
169Short 1st metacarpal (HP:0010034)1.43127370
170Mitral valve prolapse (HP:0001634)1.43040799
171Exostoses (HP:0100777)1.42911750
172Hand muscle atrophy (HP:0009130)1.42662929
173Dysmetria (HP:0001310)1.42428265
174Anterior segment dysgenesis (HP:0007700)1.42297037
175Ulnar bowing (HP:0003031)1.42009555
176Camptodactyly of toe (HP:0001836)1.42004606
177Leiomyosarcoma (HP:0100243)1.41354009
178Uterine leiomyosarcoma (HP:0002891)1.41354009
179Abnormality of the middle phalanges of the hand (HP:0009833)1.41224575

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KSR23.54268285
2EIF2AK33.44316852
3MST1R3.17240991
4LATS13.06481078
5MAP3K92.77556987
6RIPK12.64878063
7LATS22.33364269
8WEE12.23776339
9PAK62.18537212
10ERBB32.18404056
11EPHA22.12911197
12EIF2AK12.09813957
13BUB12.07956327
14DMPK2.05339721
15AKT32.02044683
16MAP3K21.98799845
17RET1.95901178
18MOS1.91755072
19ALK1.88152964
20CDC71.86807888
21SRPK11.85072669
22SCYL21.79574630
23PDGFRA1.75476323
24TSSK61.73450708
25MAP3K131.72037405
26TRIM281.68338649
27BRSK21.67232650
28PRKD31.66424915
29MAP3K61.65995360
30KSR11.62150583
31BRD41.56712874
32NEK11.55023115
33NTRK11.54938083
34STK31.54476684
35BRAF1.53932010
36BMPR21.52201209
37PAK41.52116416
38TRIB31.51790734
39STK391.48072005
40ICK1.42409374
41FGFR31.40813112
42SMG11.40492854
43TYRO31.39456598
44PDGFRB1.39361601
45LIMK11.35392488
46ERBB41.34058941
47ARAF1.33236032
48IRAK31.32589594
49DDR21.31494094
50NEK91.31257865
51CDK121.30638028
52FGFR21.30443962
53MAP3K41.25737497
54SIK31.25035936
55STK38L1.23545573
56CSNK1A1L1.17471018
57EEF2K1.16085513
58LRRK21.15592037
59STK101.14971721
60MELK1.07175133
61PKN21.06770530
62TAOK11.06427349
63BMX1.06191910
64MET1.04476554
65CSNK1G21.02143840
66TAOK31.01128338
67NME21.00328177
68MAP3K120.99201843
69FGR0.98543108
70PAK30.97395190
71CDK70.96849336
72PLK20.95655001
73YES10.94694953
74NTRK30.91445784
75PLK10.91194554
76EPHA30.90862528
77FGFR10.89640667
78NEK60.87870984
79JAK30.87170284
80PNCK0.84383987
81CDK90.83992479
82MAP3K100.83889123
83MARK10.83492255
84TAF10.83166069
85TRPM70.82313559
86CHEK20.82023342
87FER0.81703505
88CAMKK10.81649233
89NEK20.80120897
90BRSK10.79978583
91CHEK10.79054187
92DYRK30.79031963
93PRKCH0.78135471
94CSNK1G10.77952363
95ROCK20.74474214
96STK110.74093970
97PBK0.72060789
98MAPKAPK50.71892114
99RAF10.71436291
100TTN0.70839069
101CDK60.70275370
102WNK10.69745692
103EPHA40.69356290
104CSNK1G30.69216937
105PLK30.67904523
106AURKB0.67801507
107EIF2AK20.67498280
108MTOR0.66881124
109MST40.62355401
110MINK10.62037458
111PTK20.61493623
112CSNK1D0.59802176
113BCR0.59690558
114CSK0.59198195
115RPS6KB10.59127984
116EPHB10.59125453
117CDK140.58206071
118RPS6KA40.58011087
119STK240.57993386
120MAP3K80.57922996
121CDK50.56369687
122ATR0.56211545
123MARK20.55998960
124AKT20.55749034
125NTRK20.54458536
126TESK10.54213450
127ATM0.53696827
128CLK10.53146915
129FRK0.53098500
130PIM10.52628860
131PLK40.52543556
132PHKG10.51712386
133PHKG20.51712386
134PRPF4B0.51644802
135CAMKK20.51469350
136HIPK20.51131795
137OXSR10.50999774
138STK380.50730710
139JAK20.48967013
140ABL20.48518238
141MAPK100.48303797
142RPS6KB20.47834865
143PIM20.46908670
144ROCK10.46851274
145MAP2K40.46053279
146MAP3K10.46030280
147TTK0.44965926
148EGFR0.44489616
149PRKD20.41935351
150PRKCQ0.41502910
151CAMK1G0.41311079
152INSR0.41108676
153CDK150.40905429
154DAPK30.39223008
155PDK20.39135997
156CDK10.36066665
157PAK20.35161917
158MKNK10.34334440
159AURKA0.33701952
160CDK20.33540074
161CDK40.32810917

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67862851
2Cell cycle_Homo sapiens_hsa041102.50503377
3Non-homologous end-joining_Homo sapiens_hsa034502.32776719
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32113092
5DNA replication_Homo sapiens_hsa030302.32064265
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.12775682
7RNA transport_Homo sapiens_hsa030131.98724822
8Mismatch repair_Homo sapiens_hsa034301.85688819
9p53 signaling pathway_Homo sapiens_hsa041151.79604694
10Nucleotide excision repair_Homo sapiens_hsa034201.65593745
11Dorso-ventral axis formation_Homo sapiens_hsa043201.65158943
12mRNA surveillance pathway_Homo sapiens_hsa030151.58300013
13Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43761383
14Olfactory transduction_Homo sapiens_hsa047401.41994758
15Renal cell carcinoma_Homo sapiens_hsa052111.41868574
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41755817
17Glioma_Homo sapiens_hsa052141.35621975
18Biosynthesis of amino acids_Homo sapiens_hsa012301.34387511
19Spliceosome_Homo sapiens_hsa030401.33923437
20Long-term depression_Homo sapiens_hsa047301.32480360
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.29647066
22Adherens junction_Homo sapiens_hsa045201.27851330
23Pancreatic cancer_Homo sapiens_hsa052121.25301856
24Long-term potentiation_Homo sapiens_hsa047201.24400055
25Base excision repair_Homo sapiens_hsa034101.22220923
26mTOR signaling pathway_Homo sapiens_hsa041501.21793189
27ErbB signaling pathway_Homo sapiens_hsa040121.21601493
28Proteoglycans in cancer_Homo sapiens_hsa052051.20921095
29MicroRNAs in cancer_Homo sapiens_hsa052061.20442280
30Sphingolipid signaling pathway_Homo sapiens_hsa040711.19680158
31Endometrial cancer_Homo sapiens_hsa052131.19351456
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18349400
33Focal adhesion_Homo sapiens_hsa045101.17566539
34GnRH signaling pathway_Homo sapiens_hsa049121.17137775
35Pyruvate metabolism_Homo sapiens_hsa006201.15271312
36Hippo signaling pathway_Homo sapiens_hsa043901.13469547
37VEGF signaling pathway_Homo sapiens_hsa043701.13447710
38Colorectal cancer_Homo sapiens_hsa052101.13090784
39Chronic myeloid leukemia_Homo sapiens_hsa052201.12764100
40Oocyte meiosis_Homo sapiens_hsa041141.11963657
41Axon guidance_Homo sapiens_hsa043601.11215656
42Estrogen signaling pathway_Homo sapiens_hsa049151.10931146
43TGF-beta signaling pathway_Homo sapiens_hsa043501.09473225
44Phospholipase D signaling pathway_Homo sapiens_hsa040721.08936946
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08213306
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.06078783
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05589261
48Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05408976
49Circadian rhythm_Homo sapiens_hsa047101.05329915
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.02995759
51Endocytosis_Homo sapiens_hsa041441.02830840
52Gastric acid secretion_Homo sapiens_hsa049711.02701333
53Tight junction_Homo sapiens_hsa045301.02521152
54Gap junction_Homo sapiens_hsa045401.02382582
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.01752342
56Viral carcinogenesis_Homo sapiens_hsa052031.01701421
57Melanogenesis_Homo sapiens_hsa049160.99416001
58Rap1 signaling pathway_Homo sapiens_hsa040150.98687027
59AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97716816
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97113665
61Non-small cell lung cancer_Homo sapiens_hsa052230.96576286
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96435758
63Ras signaling pathway_Homo sapiens_hsa040140.96065076
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95879028
65Cholinergic synapse_Homo sapiens_hsa047250.95591305
66Viral myocarditis_Homo sapiens_hsa054160.95453161
67Platelet activation_Homo sapiens_hsa046110.95249487
68MAPK signaling pathway_Homo sapiens_hsa040100.94673192
69Glutamatergic synapse_Homo sapiens_hsa047240.94109643
70Oxytocin signaling pathway_Homo sapiens_hsa049210.93714830
71Lysine degradation_Homo sapiens_hsa003100.93509506
72Choline metabolism in cancer_Homo sapiens_hsa052310.93452549
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.93223824
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93141536
75Salivary secretion_Homo sapiens_hsa049700.92816648
76Thyroid cancer_Homo sapiens_hsa052160.92738574
77Dopaminergic synapse_Homo sapiens_hsa047280.92666427
78ECM-receptor interaction_Homo sapiens_hsa045120.91952982
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90975383
80Carbon metabolism_Homo sapiens_hsa012000.90610064
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90374600
82Pentose phosphate pathway_Homo sapiens_hsa000300.89240518
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.89062668
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.88637895
85Inositol phosphate metabolism_Homo sapiens_hsa005620.88189930
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87687994
872-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.87312581
88T cell receptor signaling pathway_Homo sapiens_hsa046600.86773714
89Wnt signaling pathway_Homo sapiens_hsa043100.85791420
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85642513
91Amoebiasis_Homo sapiens_hsa051460.85575051
92Basal transcription factors_Homo sapiens_hsa030220.85564369
93Chemokine signaling pathway_Homo sapiens_hsa040620.85373050
94Bladder cancer_Homo sapiens_hsa052190.84870507
95Insulin signaling pathway_Homo sapiens_hsa049100.84817044
96Prostate cancer_Homo sapiens_hsa052150.84740262
97Prolactin signaling pathway_Homo sapiens_hsa049170.84552370
98Central carbon metabolism in cancer_Homo sapiens_hsa052300.82911589
99Dilated cardiomyopathy_Homo sapiens_hsa054140.82249772
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81876834
101Melanoma_Homo sapiens_hsa052180.81835371
102Small cell lung cancer_Homo sapiens_hsa052220.81737710
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80922521
104cAMP signaling pathway_Homo sapiens_hsa040240.79532895
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79391883
106Sphingolipid metabolism_Homo sapiens_hsa006000.79370065
107Circadian entrainment_Homo sapiens_hsa047130.78875306
108Hedgehog signaling pathway_Homo sapiens_hsa043400.78800314
109Salmonella infection_Homo sapiens_hsa051320.78336204
110Synaptic vesicle cycle_Homo sapiens_hsa047210.77823160
111Basal cell carcinoma_Homo sapiens_hsa052170.76941495
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.74609960
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73662203
114AMPK signaling pathway_Homo sapiens_hsa041520.73181415
115Pathways in cancer_Homo sapiens_hsa052000.73116428
116Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72414409
117Toxoplasmosis_Homo sapiens_hsa051450.71550735
118Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71423461
119Shigellosis_Homo sapiens_hsa051310.71386418
120TNF signaling pathway_Homo sapiens_hsa046680.71060594
121Renin secretion_Homo sapiens_hsa049240.70940598
122FoxO signaling pathway_Homo sapiens_hsa040680.70426037
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.70324031
124Pyrimidine metabolism_Homo sapiens_hsa002400.69859830
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.69361503
126Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69324297
127Acute myeloid leukemia_Homo sapiens_hsa052210.69091100
128Vibrio cholerae infection_Homo sapiens_hsa051100.68696672
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67964664
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67882285
131B cell receptor signaling pathway_Homo sapiens_hsa046620.66763236
132Selenocompound metabolism_Homo sapiens_hsa004500.66653672
133Hepatitis C_Homo sapiens_hsa051600.66437829
134Apoptosis_Homo sapiens_hsa042100.66415069
135Osteoclast differentiation_Homo sapiens_hsa043800.66326668
136Type I diabetes mellitus_Homo sapiens_hsa049400.66305468
137Hepatitis B_Homo sapiens_hsa051610.65376009
138Legionellosis_Homo sapiens_hsa051340.65371995
139Type II diabetes mellitus_Homo sapiens_hsa049300.64367674
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64243047
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63216690
142Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63210405
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56758447
144Prion diseases_Homo sapiens_hsa050200.55933060
145One carbon pool by folate_Homo sapiens_hsa006700.55879528
146RNA degradation_Homo sapiens_hsa030180.54679724
147Arginine and proline metabolism_Homo sapiens_hsa003300.54371496
148Fatty acid biosynthesis_Homo sapiens_hsa000610.49549602
149Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.48128715
150Vitamin B6 metabolism_Homo sapiens_hsa007500.47416491
151Folate biosynthesis_Homo sapiens_hsa007900.46048879
152N-Glycan biosynthesis_Homo sapiens_hsa005100.45143911
153Arginine biosynthesis_Homo sapiens_hsa002200.43209981

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