FBXO3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants diverging at the 3' end. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.61910364
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.61910364
3L-phenylalanine metabolic process (GO:0006558)6.48230147
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.48230147
5aromatic amino acid family catabolic process (GO:0009074)5.62302379
6sulfur amino acid catabolic process (GO:0000098)5.38373069
7lysine catabolic process (GO:0006554)5.22121193
8lysine metabolic process (GO:0006553)5.22121193
9alpha-linolenic acid metabolic process (GO:0036109)5.20479319
10glyoxylate metabolic process (GO:0046487)5.10579759
11cysteine metabolic process (GO:0006534)5.01987516
12bile acid biosynthetic process (GO:0006699)4.96894481
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.93418365
14kynurenine metabolic process (GO:0070189)4.79164980
15indole-containing compound catabolic process (GO:0042436)4.73923738
16indolalkylamine catabolic process (GO:0046218)4.73923738
17tryptophan catabolic process (GO:0006569)4.73923738
18fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.60860165
19cellular ketone body metabolic process (GO:0046950)4.59252897
20urea metabolic process (GO:0019627)4.57174252
21urea cycle (GO:0000050)4.57174252
22tryptophan metabolic process (GO:0006568)4.55269122
23amino-acid betaine metabolic process (GO:0006577)4.49890972
24high-density lipoprotein particle remodeling (GO:0034375)4.47774099
25bile acid metabolic process (GO:0008206)4.37873901
26peptidyl-glutamic acid carboxylation (GO:0017187)4.24737763
27protein carboxylation (GO:0018214)4.24737763
28nitrogen cycle metabolic process (GO:0071941)4.22520773
29negative regulation of fibrinolysis (GO:0051918)4.20272865
30ethanol oxidation (GO:0006069)4.18942130
31complement activation, alternative pathway (GO:0006957)4.17941752
32alpha-amino acid catabolic process (GO:1901606)4.15388041
33acylglycerol homeostasis (GO:0055090)4.14071381
34triglyceride homeostasis (GO:0070328)4.14071381
352-oxoglutarate metabolic process (GO:0006103)4.12074809
36regulation of protein activation cascade (GO:2000257)4.09869847
37aromatic amino acid family metabolic process (GO:0009072)4.08857374
38glutamate metabolic process (GO:0006536)4.07964376
39tyrosine metabolic process (GO:0006570)4.06926507
40serine family amino acid catabolic process (GO:0009071)4.05643210
41proline biosynthetic process (GO:0006561)4.02653800
42valine metabolic process (GO:0006573)4.01813203
43DNA double-strand break processing (GO:0000729)3.99915364
44regulation of fibrinolysis (GO:0051917)3.99655027
45cellular amino acid catabolic process (GO:0009063)3.99426867
46short-chain fatty acid metabolic process (GO:0046459)3.99352199
47fatty acid beta-oxidation (GO:0006635)3.96119999
48ketone body metabolic process (GO:1902224)3.95857477
49homocysteine metabolic process (GO:0050667)3.95192909
50regulation of relaxation of muscle (GO:1901077)3.93211330
51reverse cholesterol transport (GO:0043691)3.89163575
52plasma lipoprotein particle remodeling (GO:0034369)3.83903665
53protein-lipid complex remodeling (GO:0034368)3.83903665
54macromolecular complex remodeling (GO:0034367)3.83903665
55negative regulation of fatty acid biosynthetic process (GO:0045717)3.83895465
56regulation of complement activation (GO:0030449)3.81351903
57fatty acid oxidation (GO:0019395)3.81185402
58regulation of triglyceride catabolic process (GO:0010896)3.80007670
59carnitine metabolic process (GO:0009437)3.77378291
60imidazole-containing compound metabolic process (GO:0052803)3.76065553
61coenzyme catabolic process (GO:0009109)3.75892389
62benzene-containing compound metabolic process (GO:0042537)3.75404869
63aspartate family amino acid catabolic process (GO:0009068)3.73801235
64monocarboxylic acid catabolic process (GO:0072329)3.73310755
65lipid oxidation (GO:0034440)3.72928028
66acetyl-CoA metabolic process (GO:0006084)3.72810868
67glutamine family amino acid biosynthetic process (GO:0009084)3.72545945
68fatty acid catabolic process (GO:0009062)3.72340086
69very-low-density lipoprotein particle assembly (GO:0034379)3.71444278
70oxaloacetate metabolic process (GO:0006107)3.70950013
71succinate metabolic process (GO:0006105)3.70651958
72response to nitrosative stress (GO:0051409)3.70076040
73dicarboxylic acid biosynthetic process (GO:0043650)3.69070332
74proline metabolic process (GO:0006560)3.68170428
75carboxylic acid catabolic process (GO:0046395)3.67541820
76organic acid catabolic process (GO:0016054)3.67541820
77cellular modified amino acid catabolic process (GO:0042219)3.63745580
78cholesterol efflux (GO:0033344)3.60241402
79protein localization to cilium (GO:0061512)3.58762535
80cytolysis (GO:0019835)3.55643946
81plasma lipoprotein particle assembly (GO:0034377)3.50166656
82xenobiotic catabolic process (GO:0042178)3.49328937
83bile acid and bile salt transport (GO:0015721)3.49049973
84regulation of cholesterol esterification (GO:0010872)3.48715324
85alkaloid metabolic process (GO:0009820)3.48157076
86intestinal cholesterol absorption (GO:0030299)3.47350389
87cellular glucuronidation (GO:0052695)3.44345256
88indolalkylamine metabolic process (GO:0006586)3.44182389
89regulation of cell communication by electrical coupling (GO:0010649)3.42237859
90positive regulation of glycolytic process (GO:0045821)3.41465996
91serine family amino acid metabolic process (GO:0009069)3.40431719
92presynaptic membrane assembly (GO:0097105)3.38683004
93fatty acid transmembrane transport (GO:1902001)3.38607091
94drug transmembrane transport (GO:0006855)3.38429320
95pyrimidine nucleobase catabolic process (GO:0006208)3.38170167
96response to pheromone (GO:0019236)3.36275564
97phospholipid efflux (GO:0033700)3.33832113
98branched-chain amino acid catabolic process (GO:0009083)3.32958471
99regulation of cholesterol homeostasis (GO:2000188)3.32227254
100glycine metabolic process (GO:0006544)3.30570542
101regulation of protein glycosylation (GO:0060049)3.30432194
102tricarboxylic acid metabolic process (GO:0072350)3.28716489
103branched-chain amino acid metabolic process (GO:0009081)3.28685805
104drug catabolic process (GO:0042737)3.25214130
105nicotinamide nucleotide biosynthetic process (GO:0019359)3.23462177
106pyridine nucleotide biosynthetic process (GO:0019363)3.23462177
107positive regulation of fatty acid beta-oxidation (GO:0032000)3.22363277
108plasma lipoprotein particle clearance (GO:0034381)3.21497612
109NAD biosynthetic process (GO:0009435)3.20829792
110neural tube formation (GO:0001841)3.14047034
111regulation of hexokinase activity (GO:1903299)3.11217865
112regulation of glucokinase activity (GO:0033131)3.11217865
113nucleobase catabolic process (GO:0046113)3.10212842
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09463801
115establishment of protein localization to Golgi (GO:0072600)2.99813389
116inositol phosphate catabolic process (GO:0071545)2.99464807
117protein targeting to Golgi (GO:0000042)2.97897306
118presynaptic membrane organization (GO:0097090)2.97540163
119regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95456043
120intraciliary transport (GO:0042073)2.94118415
121lipid particle organization (GO:0034389)2.84427668
122histone H2A acetylation (GO:0043968)2.79414380
123neuron cell-cell adhesion (GO:0007158)2.74912250
124nonmotile primary cilium assembly (GO:0035058)2.71497837
125regulation of sarcomere organization (GO:0060297)2.71165011
126histone mRNA catabolic process (GO:0071044)2.68485174
127dopamine transport (GO:0015872)2.67606074
128proline transport (GO:0015824)2.65955935
129detection of calcium ion (GO:0005513)2.63633352
130positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.63546840
131mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.63546840
132keratinocyte development (GO:0003334)2.62126527
133reflex (GO:0060004)2.60574440
134positive regulation of oligodendrocyte differentiation (GO:0048714)2.60293115
135positive regulation of mitochondrial fission (GO:0090141)2.59663710
136retrograde transport, vesicle recycling within Golgi (GO:0000301)2.58988814
137prostate gland growth (GO:0060736)2.58383248
138phosphorylated carbohydrate dephosphorylation (GO:0046838)2.57572896
139inositol phosphate dephosphorylation (GO:0046855)2.57572896
140ribonucleoprotein complex disassembly (GO:0032988)2.57539794
141cullin deneddylation (GO:0010388)2.55591057
142protein K11-linked deubiquitination (GO:0035871)2.54280801
143regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.52773240
144righting reflex (GO:0060013)2.52455981
145protein localization to Golgi apparatus (GO:0034067)2.51982638
146gamma-aminobutyric acid transport (GO:0015812)2.51582275
147regulation of acyl-CoA biosynthetic process (GO:0050812)2.50692632
148brain morphogenesis (GO:0048854)2.50058690
149muscle filament sliding (GO:0030049)2.49753885
150actin-myosin filament sliding (GO:0033275)2.49753885
151regulation of dendritic spine morphogenesis (GO:0061001)2.49569539
152retinal cone cell development (GO:0046549)2.47567221
153dendritic spine morphogenesis (GO:0060997)2.47051441
154acrosome assembly (GO:0001675)2.46761978
155regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.46685513
156regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.45800539
157water-soluble vitamin biosynthetic process (GO:0042364)2.45156701
158negative regulation of neurotransmitter transport (GO:0051589)2.44198648
159neurotransmitter uptake (GO:0001504)2.43865635
160glycosphingolipid biosynthetic process (GO:0006688)2.42693010
161cilium organization (GO:0044782)2.41741251
162regulation of actin filament-based movement (GO:1903115)2.38578823
163cilium assembly (GO:0042384)2.38081164
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.36423349
165neuron fate determination (GO:0048664)2.35761227
166regulation of dendritic spine development (GO:0060998)2.35620019
167cilium morphogenesis (GO:0060271)2.35550693
168C4-dicarboxylate transport (GO:0015740)2.34111815
169neuronal action potential propagation (GO:0019227)2.34083681
170limb bud formation (GO:0060174)2.33630743
171negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33280593
172positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.32487688
173regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.32487688
174acrosome reaction (GO:0007340)2.31448991
175polyol catabolic process (GO:0046174)2.30872553
176regulation of sulfur metabolic process (GO:0042762)2.29420767
177positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.28480158
178negative regulation of DNA recombination (GO:0045910)2.28373919
179intra-Golgi vesicle-mediated transport (GO:0006891)2.27450715
180actin-mediated cell contraction (GO:0070252)2.27127895
181Golgi to endosome transport (GO:0006895)2.26586281
182protein K63-linked deubiquitination (GO:0070536)2.26370024
183prenylation (GO:0097354)2.25995021
184protein prenylation (GO:0018342)2.25995021
185signal peptide processing (GO:0006465)2.25442914
186growth hormone receptor signaling pathway (GO:0060396)2.25030817
187regulation of oligodendrocyte differentiation (GO:0048713)2.24786766
188peptidyl-histidine modification (GO:0018202)2.23908195
189olfactory bulb development (GO:0021772)2.23857274
190anterograde synaptic vesicle transport (GO:0048490)2.23665507
191positive regulation of mRNA processing (GO:0050685)2.22787579
192atrial cardiac muscle cell action potential (GO:0086014)2.22541772
193regulation of short-term neuronal synaptic plasticity (GO:0048172)2.21517247
194inner ear receptor stereocilium organization (GO:0060122)2.19697294
195cellular component assembly involved in morphogenesis (GO:0010927)2.19192817
196regulation of skeletal muscle cell differentiation (GO:2001014)2.18382386
197auditory behavior (GO:0031223)2.17913913
198axoneme assembly (GO:0035082)2.17091520

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.71827266
2PPARA_22158963_ChIP-Seq_LIVER_Mouse6.47791420
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.69405494
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse5.37175953
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.30292835
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.76680606
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.75223037
8CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02341746
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.74186439
10POU3F2_20337985_ChIP-ChIP_501MEL_Human3.41461334
11GBX2_23144817_ChIP-Seq_PC3_Human3.02135737
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.97430213
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.96157640
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.96131599
15FUS_26573619_Chip-Seq_HEK293_Human2.71535311
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.66876213
17IGF1R_20145208_ChIP-Seq_DFB_Human2.62531791
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42386486
19ZNF274_21170338_ChIP-Seq_K562_Hela2.40789165
20PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.38868364
21TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.35057491
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.30676934
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.21083923
24GATA1_22025678_ChIP-Seq_K562_Human2.19120244
25FLI1_27457419_Chip-Seq_LIVER_Mouse2.17176818
26P300_19829295_ChIP-Seq_ESCs_Human2.10143026
27VDR_22108803_ChIP-Seq_LS180_Human2.09791009
28BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07584207
29* EWS_26573619_Chip-Seq_HEK293_Human2.03530593
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01688905
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.4507374
32* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.97516072
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.93672402
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.93570892
35SMAD4_21799915_ChIP-Seq_A2780_Human1.93392238
36PIAS1_25552417_ChIP-Seq_VCAP_Human1.86503889
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85548176
38MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.82960971
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.80910693
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78939861
41CLOCK_20551151_ChIP-Seq_293T_Human1.78182647
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77390793
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73519291
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.71180006
45HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70167417
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.68026884
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67985600
48CBP_20019798_ChIP-Seq_JUKART_Human1.64377158
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.64377158
50STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.64369440
51UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64279396
52ER_23166858_ChIP-Seq_MCF-7_Human1.64142559
53ZNF263_19887448_ChIP-Seq_K562_Human1.62886361
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.59506674
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57549920
56STAT3_23295773_ChIP-Seq_U87_Human1.55581204
57TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.53794740
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52378408
59* NANOG_18555785_Chip-Seq_ESCs_Mouse1.52107924
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50709622
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.48184145
62AR_25329375_ChIP-Seq_VCAP_Human1.46664019
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46606873
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45548519
65FOXA2_19822575_ChIP-Seq_HepG2_Human1.45241860
66EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42239207
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.41986450
68* ELK1_19687146_ChIP-ChIP_HELA_Human1.40675139
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39755598
70P53_22387025_ChIP-Seq_ESCs_Mouse1.39302606
71TCF4_23295773_ChIP-Seq_U87_Human1.38880812
72FLI1_21867929_ChIP-Seq_TH2_Mouse1.33942311
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33892988
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32045897
75RNF2_27304074_Chip-Seq_NSC_Mouse1.32029216
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.30815096
77HTT_18923047_ChIP-ChIP_STHdh_Human1.26842270
78HNF4A_19822575_ChIP-Seq_HepG2_Human1.26402026
79* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26183357
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26179170
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25658272
82* E2F1_18555785_Chip-Seq_ESCs_Mouse1.25586299
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25569861
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24436735
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24436735
86RXRA_24833708_ChIP-Seq_LIVER_Mouse1.21333429
87SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.20932986
88* RUNX2_22187159_ChIP-Seq_PCA_Human1.19961298
89* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.19929732
90SOX2_19829295_ChIP-Seq_ESCs_Human1.19797689
91NANOG_19829295_ChIP-Seq_ESCs_Human1.19797689
92* CMYC_18555785_Chip-Seq_ESCs_Mouse1.19742199
93TAL1_26923725_Chip-Seq_HPCs_Mouse1.18878194
94FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18350041
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17573521
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16316436
97OCT4_21477851_ChIP-Seq_ESCs_Mouse1.16060218
98EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.16058468
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.15213864
100TCF4_22108803_ChIP-Seq_LS180_Human1.15039258
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13705079
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13568731
103* P300_18555785_Chip-Seq_ESCs_Mouse1.11843402
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.11135645
105EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10632649
106TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09502035
107POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09502035
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.08381465
109* CDX2_22108803_ChIP-Seq_LS180_Human1.07854058
110GATA1_19941826_ChIP-Seq_K562_Human1.03571854
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.03187717
112* SOX2_18555785_Chip-Seq_ESCs_Mouse1.02206126
113KDM2B_26808549_Chip-Seq_REH_Human1.02169928
114* OCT4_18555785_Chip-Seq_ESCs_Mouse1.00895605
115PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00234916
116SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00187532
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99960818
118GABP_17652178_ChIP-ChIP_JURKAT_Human0.99650660
119RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99606371
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98930931
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98907104
122TBL1_22424771_ChIP-Seq_293T_Human0.98091607
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.98055691
124TAF15_26573619_Chip-Seq_HEK293_Human0.97989272
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97213828
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93185044
127SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.92441103
128* RARA_24833708_ChIP-Seq_LIVER_Mouse0.90593964
129GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89514957
130THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.88826870
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88545396
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88349019
133* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87867825
134* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87229038
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.85857875
136LXR_22292898_ChIP-Seq_THP-1_Human0.82761895
137RARB_24833708_ChIP-Seq_LIVER_Mouse0.81257669
138PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80661220
139PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78210978
140RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77975088
141AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76924328
142BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.75320298
143SRF_21415370_ChIP-Seq_HL-1_Mouse0.74606948
144ELF1_17652178_ChIP-ChIP_JURKAT_Human0.73696273
145SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.72200920
146PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71332689
147GATA4_21415370_ChIP-Seq_HL-1_Mouse0.69151548
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.68155701
149STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.68123234
150LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.67614807
151IRF8_22096565_ChIP-ChIP_GC-B_Human0.67573102
152BCAT_22108803_ChIP-Seq_LS180_Human0.67346349
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.67222625
154ETS1_21867929_ChIP-Seq_TH2_Mouse0.66211997
155GATA2_19941826_ChIP-Seq_K562_Human0.65615126
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64031855
157PU.1_20513432_ChIP-Seq_Bcells_Mouse0.63197076
158SPI1_26923725_Chip-Seq_HPCs_Mouse0.60766712
159AR_20517297_ChIP-Seq_VCAP_Human0.60366152
160IRF1_19129219_ChIP-ChIP_H3396_Human0.60014994
161STAT3_1855785_ChIP-Seq_MESCs_Mouse0.59815732
162NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.58957320
163SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.58950997
164FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.56878792
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.56543720
166DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.54843091
167ESR1_20079471_ChIP-ChIP_T-47D_Human0.53569970
168CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.53476233
169DNAJC2_21179169_ChIP-ChIP_NT2_Human0.53402976
170CTCF_21964334_ChIP-Seq_BJAB-B_Human0.51836906
171REST_18959480_ChIP-ChIP_MESCs_Mouse0.51643912
172GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.51107779
173FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.50823767
174* GATA4_25053715_ChIP-Seq_YYC3_Human0.50021529
175TET1_21451524_ChIP-Seq_MESCs_Mouse0.49123032
176E2F1_18555785_ChIP-Seq_MESCs_Mouse0.48889417
177AUTS2_25519132_ChIP-Seq_293T-REX_Human0.48553636
178GATA2_22383799_ChIP-Seq_G1ME_Mouse0.47940326
179ERG_20887958_ChIP-Seq_HPC-7_Mouse0.47767972
180NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.47296354
181LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.47170346
182SCL_19346495_ChIP-Seq_HPC-7_Human0.46435632
183GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.46075288
184ERG_20517297_ChIP-Seq_VCAP_Human0.45125289
185PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.44299915
186E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.44281913
187* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.44234025
188RAC3_21632823_ChIP-Seq_H3396_Human0.44192596
189SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.43997372
190RAD21_21589869_ChIP-Seq_MESCs_Mouse0.43811445
191KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.43573455
192ESET_19884257_ChIP-Seq_ESCs_Mouse0.40681431
193ETS1_22383799_ChIP-Seq_G1ME_Mouse0.40387164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.26823771
2MP0005365_abnormal_bile_salt6.27986236
3MP0005360_urolithiasis5.98768853
4MP0005085_abnormal_gallbladder_physiolo5.86647644
5MP0008875_abnormal_xenobiotic_pharmacok4.82818797
6MP0003806_abnormal_nucleotide_metabolis3.81504453
7MP0003252_abnormal_bile_duct3.57682846
8MP0003195_calcinosis3.22280895
9MP0010329_abnormal_lipoprotein_level3.20627528
10MP0003880_abnormal_central_pattern3.04301020
11MP0005083_abnormal_biliary_tract2.98200495
12MP0000569_abnormal_digit_pigmentation2.95290685
13MP0004145_abnormal_muscle_electrophysio2.88132550
14MP0003656_abnormal_erythrocyte_physiolo2.62381647
15MP0001666_abnormal_nutrient_absorption2.53574373
16MP0004270_analgesia2.53359229
17MP0005332_abnormal_amino_acid2.43794576
18MP0003787_abnormal_imprinting2.34200382
19MP0008877_abnormal_DNA_methylation2.32230741
20MP0002102_abnormal_ear_morphology2.24516685
21MP0002638_abnormal_pupillary_reflex2.07494796
22MP0002118_abnormal_lipid_homeostasis2.05830098
23MP0001984_abnormal_olfaction2.02874597
24MP0000609_abnormal_liver_physiology1.99057594
25MP0003868_abnormal_feces_composition1.96997908
26MP0001764_abnormal_homeostasis1.96807877
27MP0009840_abnormal_foam_cell1.95116719
28MP0002837_dystrophic_cardiac_calcinosis1.90145210
29MP0005319_abnormal_enzyme/_coenzyme1.88042040
30MP0006276_abnormal_autonomic_nervous1.87351381
31MP0004130_abnormal_muscle_cell1.80891295
32MP0006036_abnormal_mitochondrial_physio1.79995478
33MP0009745_abnormal_behavioral_response1.76931476
34MP0009046_muscle_twitch1.72425358
35MP0005584_abnormal_enzyme/coenzyme_acti1.69074202
36MP0003191_abnormal_cellular_cholesterol1.67831861
37MP0001486_abnormal_startle_reflex1.62625590
38MP0004142_abnormal_muscle_tone1.62100952
39MP0004147_increased_porphyrin_level1.60544944
40MP0004019_abnormal_vitamin_homeostasis1.59485659
41MP0000427_abnormal_hair_cycle1.59248664
42MP0004484_altered_response_of1.54756326
43MP0000749_muscle_degeneration1.54688935
44MP0005253_abnormal_eye_physiology1.54262862
45MP0009697_abnormal_copulation1.53591329
46MP0002272_abnormal_nervous_system1.50798057
47MP0005248_abnormal_Harderian_gland1.44975982
48MP0003122_maternal_imprinting1.44734420
49MP0003221_abnormal_cardiomyocyte_apopto1.43869076
50MP0002078_abnormal_glucose_homeostasis1.43316087
51MP0002138_abnormal_hepatobiliary_system1.43287025
52MP0004084_abnormal_cardiac_muscle1.40770440
53MP0004043_abnormal_pH_regulation1.37453995
54MP0008057_abnormal_DNA_replication1.36853607
55MP0003635_abnormal_synaptic_transmissio1.36194252
56MP0005220_abnormal_exocrine_pancreas1.35612689
57MP0001188_hyperpigmentation1.35544797
58MP0002332_abnormal_exercise_endurance1.30372715
59MP0000516_abnormal_urinary_system1.30169771
60MP0005367_renal/urinary_system_phenotyp1.30169771
61MP0010234_abnormal_vibrissa_follicle1.30168365
62MP0002064_seizures1.28534271
63MP0005620_abnormal_muscle_contractility1.27946568
64MP0002876_abnormal_thyroid_physiology1.27486795
65MP0002734_abnormal_mechanical_nocicepti1.26249414
66MP0000778_abnormal_nervous_system1.25897221
67MP0004924_abnormal_behavior1.25569157
68MP0005386_behavior/neurological_phenoty1.25569157
69MP0002067_abnormal_sensory_capabilities1.21966102
70MP0003186_abnormal_redox_activity1.21539195
71MP0002063_abnormal_learning/memory/cond1.21429358
72MP0009643_abnormal_urine_homeostasis1.21172767
73MP0003121_genomic_imprinting1.20943434
74MP0008789_abnormal_olfactory_epithelium1.20473203
75MP0002572_abnormal_emotion/affect_behav1.18405576
76MP0003137_abnormal_impulse_conducting1.15314076
77MP0004085_abnormal_heartbeat1.14696467
78MP0005551_abnormal_eye_electrophysiolog1.14468600
79MP0005636_abnormal_mineral_homeostasis1.13911354
80MP0002106_abnormal_muscle_physiology1.13784536
81MP0005266_abnormal_metabolism1.12752512
82MP0000598_abnormal_liver_morphology1.11652640
83MP0010678_abnormal_skin_adnexa1.11646899
84MP0001177_atelectasis1.10475527
85MP0005535_abnormal_body_temperature1.09573998
86MP0002971_abnormal_brown_adipose1.09049297
87MP0004859_abnormal_synaptic_plasticity1.06337070
88MP0001440_abnormal_grooming_behavior1.05575013
89MP0002557_abnormal_social/conspecific_i1.05036133
90MP0000013_abnormal_adipose_tissue1.04903517
91MP0002751_abnormal_autonomic_nervous1.02268240
92MP0010386_abnormal_urinary_bladder1.01048449
93MP0002972_abnormal_cardiac_muscle1.00809994
94MP0001501_abnormal_sleep_pattern1.00484219
95MP0004811_abnormal_neuron_physiology0.99601086
96MP0002877_abnormal_melanocyte_morpholog0.99472794
97MP0006035_abnormal_mitochondrial_morpho0.97993885
98MP0000639_abnormal_adrenal_gland0.97407369
99MP0005369_muscle_phenotype0.97289049
100MP0003011_delayed_dark_adaptation0.96576515
101MP0004885_abnormal_endolymph0.96468049
102MP0001968_abnormal_touch/_nociception0.95889063
103MP0005376_homeostasis/metabolism_phenot0.94662270
104MP0002269_muscular_atrophy0.94052190
105MP0000383_abnormal_hair_follicle0.93290304
106MP0002735_abnormal_chemical_nociception0.92798730
107MP0005334_abnormal_fat_pad0.92351264
108MP0009703_decreased_birth_body0.90696352
109MP0005084_abnormal_gallbladder_morpholo0.90378333
110MP0009642_abnormal_blood_homeostasis0.89601382
111MP0002909_abnormal_adrenal_gland0.88148803
112MP0005448_abnormal_energy_balance0.87984840
113MP0002928_abnormal_bile_duct0.87714317
114MP0003953_abnormal_hormone_level0.86915058
115MP0000372_irregular_coat_pigmentation0.86815426
116MP0000631_abnormal_neuroendocrine_gland0.85572150
117MP0001529_abnormal_vocalization0.85027649
118MP0001944_abnormal_pancreas_morphology0.84095028
119MP0008058_abnormal_DNA_repair0.83901598
120MP0005647_abnormal_sex_gland0.83840812
121MP0002069_abnormal_eating/drinking_beha0.83733732
122MP0003172_abnormal_lysosome_physiology0.83075223
123MP0000647_abnormal_sebaceous_gland0.82025564
124MP0005646_abnormal_pituitary_gland0.79572404
125MP0002127_abnormal_cardiovascular_syste0.78024313
126MP0001970_abnormal_pain_threshold0.77376519
127MP0002184_abnormal_innervation0.77131438
128MP0002090_abnormal_vision0.75918694
129MP0005394_taste/olfaction_phenotype0.75822338
130MP0002693_abnormal_pancreas_physiology0.75352100
131MP0009780_abnormal_chondrocyte_physiolo0.74665524
132MP0004233_abnormal_muscle_weight0.73520371
133MP0002822_catalepsy0.72655733
134MP0004215_abnormal_myocardial_fiber0.71351496
135MP0002970_abnormal_white_adipose0.70908319
136MP0001756_abnormal_urination0.70060483
137MP0009763_increased_sensitivity_to0.69788315
138MP0002009_preneoplasia0.69275553
139MP0005330_cardiomyopathy0.68655956
140MP0003646_muscle_fatigue0.65602634
141MP0009764_decreased_sensitivity_to0.63835603
142MP0004264_abnormal_extraembryonic_tissu0.62010025
143MP0008872_abnormal_physiological_respon0.60681472
144MP0008961_abnormal_basal_metabolism0.60588600
145MP0000604_amyloidosis0.59547444
146MP0008469_abnormal_protein_level0.59214432
147MP0005670_abnormal_white_adipose0.59051148
148MP0005187_abnormal_penis_morphology0.58942878
149MP0003959_abnormal_lean_body0.58304883
150MP0009115_abnormal_fat_cell0.57631744
151MP0005058_abnormal_lysosome_morphology0.57522676
152MP0003633_abnormal_nervous_system0.56116387
153MP0000003_abnormal_adipose_tissue0.55800440
154MP0009765_abnormal_xenobiotic_induced0.54789397
155MP0001502_abnormal_circadian_rhythm0.53188352
156MP0005464_abnormal_platelet_physiology0.52972843
157MP0003638_abnormal_response/metabolism_0.52856226
158MP0001545_abnormal_hematopoietic_system0.51849374
159MP0005397_hematopoietic_system_phenotyp0.51849374
160MP0008874_decreased_physiological_sensi0.51751049
161MP0005666_abnormal_adipose_tissue0.47603140
162MP0002166_altered_tumor_susceptibility0.47283527
163MP0005645_abnormal_hypothalamus_physiol0.47081723
164MP0000751_myopathy0.46511943
165MP0003300_gastrointestinal_ulcer0.46088270
166MP0000747_muscle_weakness0.44453194
167MP0005452_abnormal_adipose_tissue0.44240449
168MP0004036_abnormal_muscle_relaxation0.42170336
169MP0006072_abnormal_retinal_apoptosis0.42134668
170MP0000371_diluted_coat_color0.41738535
171MP0000230_abnormal_systemic_arterial0.41704322
172MP0005075_abnormal_melanosome_morpholog0.40952517
173MP0001765_abnormal_ion_homeostasis0.40229374

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.52267184
2Intrahepatic cholestasis (HP:0001406)5.77211067
3Hypobetalipoproteinemia (HP:0003563)5.20765631
4Deep venous thrombosis (HP:0002625)5.19224639
5Abnormality of monocarboxylic acid metabolism (HP:0010996)5.13513343
6Hypoglycemic coma (HP:0001325)5.08201651
7Ketosis (HP:0001946)4.74300150
8Prolonged partial thromboplastin time (HP:0003645)4.60512777
9Ketoacidosis (HP:0001993)4.59809399
10Xanthomatosis (HP:0000991)4.57720072
11Hyperammonemia (HP:0001987)4.22937949
12Hyperlipoproteinemia (HP:0010980)3.95805559
13Hypolipoproteinemia (HP:0010981)3.92239023
14Muscle hypertrophy of the lower extremities (HP:0008968)3.91742795
15Calf muscle hypertrophy (HP:0008981)3.87341272
16Medial flaring of the eyebrow (HP:0010747)3.84173494
17Abnormality of the intrinsic pathway (HP:0010989)3.70799113
18Gait imbalance (HP:0002141)3.68589637
19Abnormality of the common coagulation pathway (HP:0010990)3.64959308
20Exercise-induced muscle cramps (HP:0003710)3.63507272
21Hypoglycemic seizures (HP:0002173)3.59823384
22Nemaline bodies (HP:0003798)3.56675613
23Fat malabsorption (HP:0002630)3.56365680
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.56317416
25Congenital primary aphakia (HP:0007707)3.55893788
26Hyperbilirubinemia (HP:0002904)3.53997669
27Complement deficiency (HP:0004431)3.53470820
28Muscle fiber inclusion bodies (HP:0100299)3.52728309
29Abnormality of fatty-acid metabolism (HP:0004359)3.52043971
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.46824363
31Hyperglycinemia (HP:0002154)3.42247765
32Epidermoid cyst (HP:0200040)3.41069950
33Hypoalphalipoproteinemia (HP:0003233)3.35687398
34Hypochromic microcytic anemia (HP:0004840)3.32458675
35Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.30811419
36Nephrogenic diabetes insipidus (HP:0009806)3.21421306
37Hyperglycinuria (HP:0003108)3.21253429
38Hyperinsulinemic hypoglycemia (HP:0000825)3.15811775
39Abnormality of methionine metabolism (HP:0010901)3.14903430
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.13759357
41Joint hemorrhage (HP:0005261)3.11147351
42Abnormality of aspartate family amino acid metabolism (HP:0010899)3.07763168
43Abnormality of serine family amino acid metabolism (HP:0010894)3.05340061
44Abnormality of glycine metabolism (HP:0010895)3.05340061
45Genital tract atresia (HP:0001827)3.02426129
46Conjugated hyperbilirubinemia (HP:0002908)3.00714808
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.93112329
48Myoglobinuria (HP:0002913)2.87514293
49Metabolic acidosis (HP:0001942)2.84166943
50Thyroiditis (HP:0100646)2.82675046
51Pancreatic islet-cell hyperplasia (HP:0004510)2.81039855
52Delayed CNS myelination (HP:0002188)2.76640354
53Vaginal atresia (HP:0000148)2.76491123
54Late onset (HP:0003584)2.74741164
55Hypothermia (HP:0002045)2.74277030
56Gout (HP:0001997)2.73906366
57Steatorrhea (HP:0002570)2.73508637
58Abnormality of dicarboxylic acid metabolism (HP:0010995)2.72106656
59Dicarboxylic aciduria (HP:0003215)2.72106656
60Generalized aminoaciduria (HP:0002909)2.71320395
61Abnormality of serum amino acid levels (HP:0003112)2.69455359
62Abnormality of the pancreatic islet cells (HP:0006476)2.68843927
63Abnormality of endocrine pancreas physiology (HP:0012093)2.68843927
64Abnormal gallbladder morphology (HP:0012437)2.67702104
65Abnormality of the calf musculature (HP:0001430)2.65163900
66Pancreatic fibrosis (HP:0100732)2.64347169
67Symptomatic seizures (HP:0011145)2.63014931
68Methylmalonic acidemia (HP:0002912)2.62193151
69Acanthocytosis (HP:0001927)2.60565937
70Cholelithiasis (HP:0001081)2.60305296
71Atonic seizures (HP:0010819)2.60057725
72Rimmed vacuoles (HP:0003805)2.57081034
73Pancreatic cysts (HP:0001737)2.55962074
74Hypercholesterolemia (HP:0003124)2.54897870
75Lethargy (HP:0001254)2.52296388
76Febrile seizures (HP:0002373)2.51576709
77Cerebral edema (HP:0002181)2.50674755
78Poor coordination (HP:0002370)2.48514072
79Hepatocellular carcinoma (HP:0001402)2.48346936
80Abnormality of purine metabolism (HP:0004352)2.45792615
81Abnormality of the hip-girdle musculature (HP:0001445)2.45240739
82Abnormality of the musculature of the pelvis (HP:0001469)2.45240739
83Poikilocytosis (HP:0004447)2.44366930
84Abnormality of nucleobase metabolism (HP:0010932)2.44336277
85Abnormality of complement system (HP:0005339)2.41766546
86Abnormality of pyrimidine metabolism (HP:0004353)2.41423601
87True hermaphroditism (HP:0010459)2.38724196
88Curly hair (HP:0002212)2.38239383
89Papillary thyroid carcinoma (HP:0002895)2.37445273
90Growth hormone excess (HP:0000845)2.36269439
91Hyperglycemia (HP:0003074)2.35965100
92Skin nodule (HP:0200036)2.35667086
93Progressive inability to walk (HP:0002505)2.35445879
94Difficulty running (HP:0009046)2.29778384
95Hyperventilation (HP:0002883)2.29058185
96Abnormality of the heme biosynthetic pathway (HP:0010472)2.25398433
97Neonatal onset (HP:0003623)2.24075431
98Fair hair (HP:0002286)2.23947126
99Specific learning disability (HP:0001328)2.22284035
100Tubulointerstitial nephritis (HP:0001970)2.20555996
101Hepatic necrosis (HP:0002605)2.19918861
102Drooling (HP:0002307)2.19645683
103Irritability (HP:0000737)2.18053040
104Acute hepatic failure (HP:0006554)2.16313101
105Large for gestational age (HP:0001520)2.15830799
106Spastic diplegia (HP:0001264)2.14493426
107Vomiting (HP:0002013)2.12743189
108Insulin-resistant diabetes mellitus (HP:0000831)2.11585472
109Limb dystonia (HP:0002451)2.10774073
110Inability to walk (HP:0002540)2.10191020
111Proximal amyotrophy (HP:0007126)2.10123577
112Pheochromocytoma (HP:0002666)2.08541810
113Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.07956508
114Turricephaly (HP:0000262)2.07612565
115Volvulus (HP:0002580)2.07357968
116Nephronophthisis (HP:0000090)2.07012691
117Abnormality of the gallbladder (HP:0005264)2.06078922
118Brushfield spots (HP:0001088)2.05265300
119Thyroid carcinoma (HP:0002890)2.04032776
120Status epilepticus (HP:0002133)2.03504119
121Broad-based gait (HP:0002136)2.03463269
122Excessive salivation (HP:0003781)2.01890419
123Focal motor seizures (HP:0011153)2.00416499
124Dialeptic seizures (HP:0011146)1.99007858
125Gaze-evoked nystagmus (HP:0000640)1.97935605
126Abnormality of the renal cortex (HP:0011035)1.97347745
127Abnormality of the renal medulla (HP:0100957)1.95175975
128Exercise-induced myalgia (HP:0003738)1.93757771
129Hemiparesis (HP:0001269)1.92415357
130Abnormal gallbladder physiology (HP:0012438)1.92399255
131Cholecystitis (HP:0001082)1.92399255
132EEG with generalized epileptiform discharges (HP:0011198)1.90569690
133Muscular hypotonia of the trunk (HP:0008936)1.90494440
134Frequent falls (HP:0002359)1.90395543
135Hypsarrhythmia (HP:0002521)1.90313297
136Myocardial infarction (HP:0001658)1.90241393
137Spontaneous abortion (HP:0005268)1.89594015
138Progressive macrocephaly (HP:0004481)1.89556251
139Polycythemia (HP:0001901)1.89552671
140Palpitations (HP:0001962)1.89433178
141Limb hypertonia (HP:0002509)1.89394673
142Increased muscle lipid content (HP:0009058)1.88928185
143Dyskinesia (HP:0100660)1.88306169
144Ragged-red muscle fibers (HP:0003200)1.87423541
145Generalized hyperpigmentation (HP:0007440)1.87111155
146Epileptiform EEG discharges (HP:0011182)1.87108001
147Molar tooth sign on MRI (HP:0002419)1.86861472
148Abnormality of midbrain morphology (HP:0002418)1.86861472
149Focal seizures (HP:0007359)1.86512054
150Degeneration of the lateral corticospinal tracts (HP:0002314)1.85983175
151Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85983175
152Pancreatitis (HP:0001733)1.85342871
153Left ventricular hypertrophy (HP:0001712)1.83470391
154Stomach cancer (HP:0012126)1.83167482
155Neuroendocrine neoplasm (HP:0100634)1.82990041
156Mitral stenosis (HP:0001718)1.81829749
157Mucopolysacchariduria (HP:0008155)1.81336662
158Urinary glycosaminoglycan excretion (HP:0003541)1.81336662
159Pelvic girdle muscle weakness (HP:0003749)1.80620306
160Renal cortical cysts (HP:0000803)1.80505570
161Methylmalonic aciduria (HP:0012120)1.79320876
162Oligomenorrhea (HP:0000876)1.76785493
163Proximal tubulopathy (HP:0000114)1.76634429
164Rhabdomyolysis (HP:0003201)1.76532569
165Sensorimotor neuropathy (HP:0007141)1.76011538
166Postaxial hand polydactyly (HP:0001162)1.75669862
167Opisthotonus (HP:0002179)1.75411716
168EMG: myopathic abnormalities (HP:0003458)1.75128722
169Tongue fasciculations (HP:0001308)1.75000854
170Cerebral palsy (HP:0100021)1.74869110
171Decreased testicular size (HP:0008734)1.74156897
172Abnormality of vitamin B metabolism (HP:0004340)1.73958951
173Abnormality of the metopic suture (HP:0005556)1.73167362
174Aplasia/Hypoplasia of the lens (HP:0008063)1.72091654
175Shoulder girdle muscle weakness (HP:0003547)1.71100824
176Severe combined immunodeficiency (HP:0004430)1.70869467
177Absent speech (HP:0001344)1.69571822
178Prominent metopic ridge (HP:0005487)1.68674048
179Widely spaced teeth (HP:0000687)1.68653378
180Amyotrophic lateral sclerosis (HP:0007354)1.68051344
181Oligodactyly (hands) (HP:0001180)1.67123779
182Colon cancer (HP:0003003)1.66017736
183Abnormality of macular pigmentation (HP:0008002)1.65610061
184Broad foot (HP:0001769)1.63911986
185Abnormality of the vitamin B12 metabolism (HP:0004341)1.62982122
186Aplasia/Hypoplasia of the tibia (HP:0005772)1.62568908
187Ulnar claw (HP:0001178)1.60847072

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.16785150
2INSRR4.37514901
3BMPR1B3.92350163
4MAPK153.51219983
5FLT33.01064921
6CASK2.77589829
7PINK12.76727547
8SIK12.72205354
9TRIM282.60891682
10MAP3K62.48527353
11BCR2.47313599
12PDK42.34653430
13PDK32.34653430
14MAP3K112.16357318
15MKNK22.07915760
16MAP2K42.07863463
17ERN12.06815846
18DAPK12.01985473
19MAP4K21.98751285
20PKN21.97886610
21TRIB31.92699652
22MARK11.92388288
23TAOK31.88797190
24FRK1.85779016
25AKT31.83929748
26PIK3CG1.83522887
27TGFBR11.77061076
28FGFR41.73362066
29NEK11.73337954
30DYRK1B1.69521712
31MAPK111.56100658
32MKNK11.56063099
33PLK21.54399232
34TNIK1.53056215
35MAP3K41.48522984
36HIPK21.45523217
37ICK1.39642138
38EIF2AK31.37378863
39SCYL21.37163576
40FGFR21.36957931
41MST41.36948461
42MAP3K121.35666446
43BRSK21.35629610
44RPS6KA41.35097193
45DAPK21.34897855
46MAPK131.34695218
47CSNK1G21.28652082
48PHKG11.27171889
49PHKG21.27171889
50CSNK1G11.26777680
51CDK81.23856215
52MATK1.17857025
53NUAK11.17410344
54BRD41.16402691
55CSNK1G31.14836722
56EPHA31.14485313
57CDK61.10333692
58UHMK11.09674597
59FER1.09191859
60STK38L1.08326457
61EPHA41.07813823
62RIPK11.06069332
63JAK21.05428584
64TSSK61.05382470
65PRKCE1.05341878
66PRKAA11.03132854
67CAMKK20.99698945
68SRPK10.99673846
69NLK0.92792000
70CSNK1A1L0.91433911
71OXSR10.91149905
72MAPKAPK30.90896312
73MAP2K70.89427932
74MAP3K20.89421040
75STK240.89347618
76OBSCN0.89035338
77PDK20.88320651
78PDGFRA0.86237771
79PRKAA20.85486919
80MAP2K30.85250454
81PLK30.85042554
82NEK90.82515527
83TNK20.82245546
84DDR20.81555038
85DYRK30.78376515
86RPS6KL10.76795641
87RPS6KC10.76795641
88CSK0.75702504
89YES10.71828480
90SGK20.71675190
91RPS6KB10.68524909
92CCNB10.68192013
93DYRK1A0.67800696
94NTRK30.67369546
95RET0.66755335
96RPS6KA60.66261287
97SGK30.64527441
98CAMK2A0.64237382
99CAMKK10.64114609
100STK390.64089281
101WNK30.62526137
102MAPK40.60535011
103PKN10.58125018
104CAMK2G0.57753282
105KIT0.57604277
106PRKCG0.57180733
107CDK30.56495402
108PASK0.54854475
109ACVR1B0.54696491
110ZAK0.54615254
111FGFR30.54401069
112MYLK0.54320120
113PRKACG0.54029832
114NTRK20.53698495
115MAP3K10.52671402
116GSK3A0.52620953
117ERBB40.52406365
118GRK10.50834572
119MAP3K50.50519956
120VRK10.49868257
121RAF10.49601804
122PNCK0.49241773
123PTK60.49221620
124PAK60.48379087
125ADRBK20.48198032
126DYRK20.48022808
127TAOK20.47882227
128TRPM70.47816632
129CDK90.46945289
130MAP3K100.46634526
131IRAK10.46591826
132SIK30.46261556
133MAP3K70.46148898
134MINK10.45205779
135ERBB30.44473549
136BMPR20.41784628
137PRKG10.41246227
138PAK30.40365694
139JAK10.40204746
140MAP2K60.37538192
141CDK50.37060960
142KSR10.36843233
143CAMK2B0.36421632
144CDK190.35134447
145STK160.34994145
146RPS6KA50.34429967
147CAMK40.34377311
148MAPK30.34279327
149PRKCZ0.34220180
150CAMK2D0.33923990
151STK30.33490063
152TEC0.32881784
153RPS6KA20.31972311
154FGFR10.31398705
155TIE10.31319492
156MAPK120.30847540
157PRKACA0.30533593
158EGFR0.29315136
159MAP2K10.28639679
160RPS6KA30.28274512
161PIM20.28042861
162TYRO30.27251810
163TBK10.26539960
164TGFBR20.26487624
165SGK4940.25543665
166SGK2230.25543665
167KSR20.24205613
168TTN0.22426374

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.91244291
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24589284
3Nitrogen metabolism_Homo sapiens_hsa009103.17879554
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.10603121
5Fatty acid degradation_Homo sapiens_hsa000712.94195431
6Arginine biosynthesis_Homo sapiens_hsa002202.91126274
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.69206958
8Propanoate metabolism_Homo sapiens_hsa006402.61166375
9Tryptophan metabolism_Homo sapiens_hsa003802.56162605
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.51320466
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36548412
12Fatty acid metabolism_Homo sapiens_hsa012122.33990312
13Nicotine addiction_Homo sapiens_hsa050332.30852134
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.27829263
15Butanoate metabolism_Homo sapiens_hsa006502.27532536
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.23866187
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22215806
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.18905891
19Peroxisome_Homo sapiens_hsa041461.97876393
20Pyruvate metabolism_Homo sapiens_hsa006201.93528195
21Complement and coagulation cascades_Homo sapiens_hsa046101.93028742
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.92658630
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71918887
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71868362
25beta-Alanine metabolism_Homo sapiens_hsa004101.69589675
26PPAR signaling pathway_Homo sapiens_hsa033201.67281133
27Selenocompound metabolism_Homo sapiens_hsa004501.59193493
28Starch and sucrose metabolism_Homo sapiens_hsa005001.55469066
29Drug metabolism - other enzymes_Homo sapiens_hsa009831.55200585
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55145977
31Non-homologous end-joining_Homo sapiens_hsa034501.54691825
32Sulfur metabolism_Homo sapiens_hsa009201.54260762
33Amphetamine addiction_Homo sapiens_hsa050311.52914579
34RNA degradation_Homo sapiens_hsa030181.52145068
35Dorso-ventral axis formation_Homo sapiens_hsa043201.52027652
36Chemical carcinogenesis_Homo sapiens_hsa052041.51199776
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48502813
38Carbon metabolism_Homo sapiens_hsa012001.47731418
39Fatty acid biosynthesis_Homo sapiens_hsa000611.46733461
40Caffeine metabolism_Homo sapiens_hsa002321.43246561
41Biosynthesis of amino acids_Homo sapiens_hsa012301.42709838
42Linoleic acid metabolism_Homo sapiens_hsa005911.42604434
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.42600009
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.39881885
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39703485
46Dopaminergic synapse_Homo sapiens_hsa047281.38941208
47Histidine metabolism_Homo sapiens_hsa003401.38624544
48Circadian entrainment_Homo sapiens_hsa047131.36854990
49Collecting duct acid secretion_Homo sapiens_hsa049661.35774966
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34912035
51Steroid hormone biosynthesis_Homo sapiens_hsa001401.33684179
52Bile secretion_Homo sapiens_hsa049761.33627374
53Folate biosynthesis_Homo sapiens_hsa007901.32756328
54Phenylalanine metabolism_Homo sapiens_hsa003601.30568901
55Basal transcription factors_Homo sapiens_hsa030221.29791087
56ABC transporters_Homo sapiens_hsa020101.28025975
57Sulfur relay system_Homo sapiens_hsa041221.23846284
58Glutamatergic synapse_Homo sapiens_hsa047241.22811212
59Ether lipid metabolism_Homo sapiens_hsa005651.21662506
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21321337
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.20536400
62Phototransduction_Homo sapiens_hsa047441.19473442
63Tyrosine metabolism_Homo sapiens_hsa003501.19169616
64Fatty acid elongation_Homo sapiens_hsa000621.16897535
65Morphine addiction_Homo sapiens_hsa050321.11557918
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11124748
67Retinol metabolism_Homo sapiens_hsa008301.09856732
68Taste transduction_Homo sapiens_hsa047421.03202606
69Oocyte meiosis_Homo sapiens_hsa041141.02726449
70Long-term depression_Homo sapiens_hsa047301.02316654
71Cocaine addiction_Homo sapiens_hsa050301.02166808
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02148683
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01501605
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.98910613
75Serotonergic synapse_Homo sapiens_hsa047260.98021629
76Renin secretion_Homo sapiens_hsa049240.98016065
77Lysine degradation_Homo sapiens_hsa003100.96809106
78Fat digestion and absorption_Homo sapiens_hsa049750.96807042
79Arginine and proline metabolism_Homo sapiens_hsa003300.93928378
80Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93191710
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.89011649
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.86031312
83Cardiac muscle contraction_Homo sapiens_hsa042600.80929728
84Staphylococcus aureus infection_Homo sapiens_hsa051500.80912503
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79095658
86Pancreatic secretion_Homo sapiens_hsa049720.77119437
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76889764
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.72488931
89Glycerolipid metabolism_Homo sapiens_hsa005610.72091206
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71908932
91Oxytocin signaling pathway_Homo sapiens_hsa049210.69965277
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64200358
93Galactose metabolism_Homo sapiens_hsa000520.63887744
94Olfactory transduction_Homo sapiens_hsa047400.60160919
95Calcium signaling pathway_Homo sapiens_hsa040200.59394219
96Salivary secretion_Homo sapiens_hsa049700.57979614
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57929360
98Pentose phosphate pathway_Homo sapiens_hsa000300.57647513
99Circadian rhythm_Homo sapiens_hsa047100.56973455
100Glucagon signaling pathway_Homo sapiens_hsa049220.56925128
101Glutathione metabolism_Homo sapiens_hsa004800.55254035
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55217735
103Ovarian steroidogenesis_Homo sapiens_hsa049130.54919302
104FoxO signaling pathway_Homo sapiens_hsa040680.54459052
105Fructose and mannose metabolism_Homo sapiens_hsa000510.52693049
106cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52079172
107Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51330000
108Insulin resistance_Homo sapiens_hsa049310.51115260
109Inositol phosphate metabolism_Homo sapiens_hsa005620.48837784
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48162520
111Metabolic pathways_Homo sapiens_hsa011000.47952643
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.47588980
113Tight junction_Homo sapiens_hsa045300.45412011
114Huntingtons disease_Homo sapiens_hsa050160.43700884
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.42639046
116Proteasome_Homo sapiens_hsa030500.41278773
117Long-term potentiation_Homo sapiens_hsa047200.41265844
118Insulin signaling pathway_Homo sapiens_hsa049100.40306040
119AMPK signaling pathway_Homo sapiens_hsa041520.39982457
120Steroid biosynthesis_Homo sapiens_hsa001000.34039096
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.33683700
122One carbon pool by folate_Homo sapiens_hsa006700.31258650
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30207263
124Vitamin digestion and absorption_Homo sapiens_hsa049770.25862622
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20324465
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17383620
127Insulin secretion_Homo sapiens_hsa049110.17016482
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15924308
129Protein export_Homo sapiens_hsa030600.14496154
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13816933
131Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13390348
132Prion diseases_Homo sapiens_hsa050200.13292103
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.12798910
134Type II diabetes mellitus_Homo sapiens_hsa049300.09772546
135N-Glycan biosynthesis_Homo sapiens_hsa005100.09699542
136Vitamin B6 metabolism_Homo sapiens_hsa007500.05757801
137Parkinsons disease_Homo sapiens_hsa050120.05497246
138Glycerophospholipid metabolism_Homo sapiens_hsa005640.04957909
139Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04582209
140Oxidative phosphorylation_Homo sapiens_hsa001900.04260702
141Regulation of autophagy_Homo sapiens_hsa041400.03730796
142Thyroid hormone synthesis_Homo sapiens_hsa049180.02310718
143mTOR signaling pathway_Homo sapiens_hsa041500.02008931
144GABAergic synapse_Homo sapiens_hsa047270.01745866
145Synaptic vesicle cycle_Homo sapiens_hsa04721-0.0783158
146alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0642032
147Alzheimers disease_Homo sapiens_hsa05010-0.0613671
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0208979
149Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962-0.0188941

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