FBXO30

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.08448901
2nuclear pore complex assembly (GO:0051292)4.87927028
3regulation of RNA export from nucleus (GO:0046831)4.77051248
4nuclear pore organization (GO:0006999)4.61133473
5multicellular organism reproduction (GO:0032504)4.53419942
6cilium or flagellum-dependent cell motility (GO:0001539)4.45480692
7sperm-egg recognition (GO:0035036)4.41605895
8piRNA metabolic process (GO:0034587)4.29431408
9binding of sperm to zona pellucida (GO:0007339)4.28052392
10pre-miRNA processing (GO:0031054)4.13623342
11cell wall macromolecule catabolic process (GO:0016998)4.08671805
12cell wall macromolecule metabolic process (GO:0044036)4.08671805
13regulation of DNA methylation (GO:0044030)3.98236272
14negative regulation of fibroblast apoptotic process (GO:2000270)3.93789687
15regulation of nucleobase-containing compound transport (GO:0032239)3.89036443
16pore complex assembly (GO:0046931)3.85745195
17protein localization to chromosome, centromeric region (GO:0071459)3.85594063
18negative regulation of histone methylation (GO:0031061)3.85360132
19cell-cell recognition (GO:0009988)3.84620681
20mitotic sister chromatid cohesion (GO:0007064)3.81936444
21cytoplasmic mRNA processing body assembly (GO:0033962)3.79550987
22reproduction (GO:0000003)3.70845900
23microtubule depolymerization (GO:0007019)3.69231107
24protein localization to kinetochore (GO:0034501)3.66671628
25plasma membrane fusion (GO:0045026)3.51716226
26acrosome assembly (GO:0001675)3.51195472
27mitotic metaphase plate congression (GO:0007080)3.39391873
28mitotic nuclear envelope disassembly (GO:0007077)3.38376300
29regulation of centriole replication (GO:0046599)3.37537256
30protoporphyrinogen IX metabolic process (GO:0046501)3.35214666
31axonemal dynein complex assembly (GO:0070286)3.34140166
32monoubiquitinated protein deubiquitination (GO:0035520)3.32567240
33male meiosis (GO:0007140)3.31393426
34DNA replication-dependent nucleosome organization (GO:0034723)3.30723876
35DNA replication-dependent nucleosome assembly (GO:0006335)3.30723876
36artery development (GO:0060840)3.30445253
37anterior/posterior axis specification, embryo (GO:0008595)3.28587691
38epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.24978531
39notochord development (GO:0030903)3.22759655
40motile cilium assembly (GO:0044458)3.22694932
41mitotic chromosome condensation (GO:0007076)3.21998021
42protoporphyrinogen IX biosynthetic process (GO:0006782)3.20067331
43cellular protein complex localization (GO:0034629)3.19181129
44sperm motility (GO:0030317)3.18733916
45regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.16518844
46membrane disassembly (GO:0030397)3.15322280
47nuclear envelope disassembly (GO:0051081)3.15322280
48kinetochore organization (GO:0051383)3.12756185
49erythrocyte development (GO:0048821)3.11293123
50metaphase plate congression (GO:0051310)3.10526263
51chromosome condensation (GO:0030261)3.10457297
52synaptonemal complex assembly (GO:0007130)3.09114201
53regulation of meiosis I (GO:0060631)3.07974826
54chondrocyte proliferation (GO:0035988)3.07058959
55sister chromatid segregation (GO:0000819)3.06641405
56paraxial mesoderm development (GO:0048339)3.04308322
57synaptonemal complex organization (GO:0070193)3.04014734
58regulation of chromatin binding (GO:0035561)3.03774898
59mitotic sister chromatid segregation (GO:0000070)3.01718872
60regulation of centrosome cycle (GO:0046605)3.00040336
61regulation of fibroblast apoptotic process (GO:2000269)2.97558754
62meiotic cell cycle (GO:0051321)2.97253016
63DNA packaging (GO:0006323)2.95982212
64outer ear morphogenesis (GO:0042473)2.95395430
65NLS-bearing protein import into nucleus (GO:0006607)2.94414585
66positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93554282
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93554282
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.93554282
69spermatid development (GO:0007286)2.91897511
70gene silencing by RNA (GO:0031047)2.90976129
71regulation of chromosome segregation (GO:0051983)2.90948209
72regulation of spindle organization (GO:0090224)2.90540953
73mRNA stabilization (GO:0048255)2.88108495
74RNA stabilization (GO:0043489)2.88108495
75regulation of cAMP-dependent protein kinase activity (GO:2000479)2.86778109
76meiotic chromosome segregation (GO:0045132)2.86486114
77nerve growth factor signaling pathway (GO:0038180)2.85549307
78establishment of chromosome localization (GO:0051303)2.84612202
79regulation of mitotic metaphase/anaphase transition (GO:0030071)2.84577842
80negative regulation of chromosome segregation (GO:0051985)2.80885130
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.80853932
82negative regulation of DNA repair (GO:0045738)2.80498019
83embryonic process involved in female pregnancy (GO:0060136)2.79859055
84spindle checkpoint (GO:0031577)2.79840802
85neuron projection extension involved in neuron projection guidance (GO:1902284)2.79292974
86axon extension involved in axon guidance (GO:0048846)2.79292974
87negative regulation of mitotic sister chromatid separation (GO:2000816)2.78999735
88negative regulation of mitotic sister chromatid segregation (GO:0033048)2.78999735
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.78999735
90negative regulation of sister chromatid segregation (GO:0033046)2.78999735
91regulation of histone H3-K9 methylation (GO:0051570)2.78591898
92regulation of NFAT protein import into nucleus (GO:0051532)2.78375810
93DNA methylation involved in gamete generation (GO:0043046)2.77658777
94cell migration involved in heart development (GO:0060973)2.77574769
95histone exchange (GO:0043486)2.76738243
96N-terminal protein amino acid acetylation (GO:0006474)2.76447549
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74344620
98iron ion import (GO:0097286)2.71330610
99DNA replication checkpoint (GO:0000076)2.70542598
100protein complex localization (GO:0031503)2.69438665
101endocardial cushion morphogenesis (GO:0003203)2.68254478
102meiotic nuclear division (GO:0007126)2.67718181
103spindle assembly checkpoint (GO:0071173)2.66786645
104regulation of mitotic sister chromatid separation (GO:0010965)2.66584685
105regulation of mitotic sister chromatid segregation (GO:0033047)2.66584685
106regulation of sister chromatid segregation (GO:0033045)2.66584685
107Notch signaling involved in heart development (GO:0061314)2.63673385
108acrosome reaction (GO:0007340)2.62044762
109oxygen transport (GO:0015671)2.61575990
110regulation of chromatin silencing (GO:0031935)2.61570552
111cell migration involved in sprouting angiogenesis (GO:0002042)2.60595993
112regulation of centrosome duplication (GO:0010824)2.60471183
113mitotic spindle assembly checkpoint (GO:0007094)2.60328393
114kinetochore assembly (GO:0051382)2.59078045
115mitotic spindle checkpoint (GO:0071174)2.58936417
116epithelial cilium movement (GO:0003351)2.58798727
117regulation of mitotic spindle organization (GO:0060236)2.58703556
118protein K6-linked ubiquitination (GO:0085020)2.58629363
119facial nerve structural organization (GO:0021612)2.58357577
120chromosome organization involved in meiosis (GO:0070192)2.58059268
121nodal signaling pathway (GO:0038092)2.57384432
122attachment of spindle microtubules to kinetochore (GO:0008608)2.56809901
123single fertilization (GO:0007338)2.56411289
124positive regulation of chromosome segregation (GO:0051984)2.55475968
125DNA replication initiation (GO:0006270)2.54362039
126glycine transport (GO:0015816)2.53329494
127protein localization to chromosome (GO:0034502)2.52256623
128musculoskeletal movement (GO:0050881)2.52112153
129multicellular organismal movement (GO:0050879)2.52112153
130mitotic G2/M transition checkpoint (GO:0044818)2.51567151
131regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.50935387
132chromatin remodeling at centromere (GO:0031055)2.50581062
133heart valve formation (GO:0003188)2.49215549
134somatic hypermutation of immunoglobulin genes (GO:0016446)2.47679504
135somatic diversification of immune receptors via somatic mutation (GO:0002566)2.47679504
136regulation of sister chromatid cohesion (GO:0007063)2.47553567
137negative regulation of potassium ion transmembrane transport (GO:1901380)2.46391959
138DNA unwinding involved in DNA replication (GO:0006268)2.44060120
139porphyrin-containing compound biosynthetic process (GO:0006779)2.43375681
140negative regulation of meiosis (GO:0045835)2.43284572
141histone H2B ubiquitination (GO:0033523)2.42167817
142histone monoubiquitination (GO:0010390)2.41686965
143protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.41457930
144positive regulation of SMAD protein import into nucleus (GO:0060391)2.39959082
145interkinetic nuclear migration (GO:0022027)2.39476741
146cytoskeleton-dependent cytokinesis (GO:0061640)2.36375167
147histone ubiquitination (GO:0016574)2.36162341
148morphogenesis of an epithelial sheet (GO:0002011)2.34975861
149heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.34066583
150regulation of DNA damage checkpoint (GO:2000001)2.32896199
151hemoglobin metabolic process (GO:0020027)2.32585508
152negative regulation of neurotransmitter secretion (GO:0046929)2.32458559
153dorsal/ventral axis specification (GO:0009950)2.32022624
154peptidyl-threonine phosphorylation (GO:0018107)2.31855320
155negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.30605216
156anatomical structure arrangement (GO:0048532)2.29438039
157spermatid nucleus differentiation (GO:0007289)2.28986124
158embryonic camera-type eye morphogenesis (GO:0048596)2.28754501
159hippo signaling (GO:0035329)2.28496176
160peptidyl-threonine modification (GO:0018210)2.28394117
161mitotic cytokinesis (GO:0000281)2.27074509
162gas transport (GO:0015669)2.26150733
163erythrocyte maturation (GO:0043249)2.26135743
164snRNA transcription (GO:0009301)2.26021600
165regulation of gene silencing by miRNA (GO:0060964)2.25465786

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.17221892
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.34589124
3FOXM1_23109430_ChIP-Seq_U2OS_Human6.08311906
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.76995540
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.69438415
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.96921109
7AR_21909140_ChIP-Seq_LNCAP_Human2.96762686
8GATA1_22025678_ChIP-Seq_K562_Human2.95533681
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.91574901
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.79623836
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.50909970
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.50850273
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.22009931
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.13426375
15* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12769237
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09852452
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.07811405
18MYC_18555785_ChIP-Seq_MESCs_Mouse1.96167173
19SMAD_19615063_ChIP-ChIP_OVARY_Human1.83749193
20TP63_19390658_ChIP-ChIP_HaCaT_Human1.83060638
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.82272772
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80664607
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78518309
24TAF15_26573619_Chip-Seq_HEK293_Human1.74973032
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74074536
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.69218604
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.58904699
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.58764393
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56586381
30HIF1A_21447827_ChIP-Seq_MCF-7_Human1.56511770
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55501141
32GBX2_23144817_ChIP-Seq_PC3_Human1.55251859
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55185932
34TP63_17297297_ChIP-ChIP_HaCaT_Human1.54198015
35* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.51849793
36OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50687852
37EWS_26573619_Chip-Seq_HEK293_Human1.50072346
38EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48171230
39AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47881140
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47444968
41STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.46011955
42* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44097715
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43605467
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42904625
45TP53_16413492_ChIP-PET_HCT116_Human1.42319177
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42196426
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40296251
48SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.39832320
49P300_19829295_ChIP-Seq_ESCs_Human1.39328029
50IGF1R_20145208_ChIP-Seq_DFB_Human1.38862908
51FUS_26573619_Chip-Seq_HEK293_Human1.36027416
52MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.34877756
53FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.33755971
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31885609
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29853228
56GATA1_19941826_ChIP-Seq_K562_Human1.25762373
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.25259771
58SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23949151
59NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23855844
60NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23855844
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21968897
62CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21356414
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20643990
64YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20448442
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.19266897
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17928858
67BRD4_25478319_ChIP-Seq_HGPS_Human1.17297908
68CLOCK_20551151_ChIP-Seq_293T_Human1.14252266
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14151230
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14088101
71SMAD3_21741376_ChIP-Seq_EPCs_Human1.13613094
72TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12867478
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12167196
74TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11695959
75* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11077792
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10853698
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.10618828
78ELK1_19687146_ChIP-ChIP_HELA_Human1.10604883
79SOX2_16153702_ChIP-ChIP_HESCs_Human1.10258397
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09842931
81FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09398140
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09180861
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.08469953
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07938755
85SMAD4_21799915_ChIP-Seq_A2780_Human1.07654472
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.07634304
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07483514
88GF1B_26923725_Chip-Seq_HPCs_Mouse1.06628769
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06378802
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04961904
91* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04403355
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03543217
93CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.03344837
94* ISL1_27105846_Chip-Seq_CPCs_Mouse1.03113492
95STAT3_23295773_ChIP-Seq_U87_Human1.02477825
96XRN2_22483619_ChIP-Seq_HELA_Human1.01698290
97TP53_18474530_ChIP-ChIP_U2OS_Human1.01182142
98CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00565155
99* SOX9_26525672_Chip-Seq_HEART_Mouse0.98702376
100NOTCH1_21737748_ChIP-Seq_TLL_Human0.98686531
101KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98023015
102KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98023015
103KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98023015
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96687168
105KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.96567417
106NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95895777
107DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.94886862
108KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.94837759
109POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.94409097
110NANOG_21062744_ChIP-ChIP_HESCs_Human0.94110822
111HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93589310
112ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93572593
113CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.92825527
114CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91742239
115POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91718900
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91523293
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91394361
118ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91092827
119NANOG_18555785_Chip-Seq_ESCs_Mouse0.90924053
120SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.89433657
121SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.88255610
122SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.88255610
123TRIM28_21343339_ChIP-Seq_HEK293_Human0.87551134
124SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.87465733
125* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87441225
126* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87256326
127TCF3_18692474_ChIP-Seq_MESCs_Mouse0.86415504
128VDR_23849224_ChIP-Seq_CD4+_Human0.85127990
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.84451369
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.83549835
131E2F1_18555785_ChIP-Seq_MESCs_Mouse0.83073948
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82888480
133FLI1_27457419_Chip-Seq_LIVER_Mouse0.82154384
134NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.82004049
135MYB_21317192_ChIP-Seq_ERMYB_Mouse0.80703623
136SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.79364702
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.78334208
138HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78201295
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.78063963
140DCP1A_22483619_ChIP-Seq_HELA_Human0.77662662
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.77104137
142TFEB_21752829_ChIP-Seq_HELA_Human0.76798680
143* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.75101511
144TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75003360
145E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74276458
146NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.73920858
147* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.73731030
148NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.73300639
149CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.73161123
150EST1_17652178_ChIP-ChIP_JURKAT_Human0.72205463
151ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.70701227
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.70040015
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.69544468
154UBF1/2_26484160_Chip-Seq_HMECs_Human0.67655252
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.67178968
156YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.67019478
157EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.66873892
158SOX17_20123909_ChIP-Seq_XEN_Mouse0.66820933
159CJUN_26792858_Chip-Seq_BT549_Human0.65873777
160* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.65575107

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition3.14593812
2MP0005410_abnormal_fertilization3.07797357
3MP0000566_synostosis2.95201353
4MP0010094_abnormal_chromosome_stability2.83021187
5MP0008057_abnormal_DNA_replication2.81937694
6MP0003111_abnormal_nucleus_morphology2.77154961
7MP0004147_increased_porphyrin_level2.74128413
8MP0010030_abnormal_orbit_morphology2.71446242
9MP0003693_abnormal_embryo_hatching2.65836873
10MP0003077_abnormal_cell_cycle2.45153802
11MP0008438_abnormal_cutaneous_collagen2.31768480
12MP0003221_abnormal_cardiomyocyte_apopto2.26330947
13MP0008877_abnormal_DNA_methylation2.12158473
14MP0005257_abnormal_intraocular_pressure2.07009403
15MP0002877_abnormal_melanocyte_morpholog2.05970115
16MP0003705_abnormal_hypodermis_morpholog2.03568376
17MP0010352_gastrointestinal_tract_polyps2.01868977
18MP0008007_abnormal_cellular_replicative1.97501903
19MP0008058_abnormal_DNA_repair1.91322853
20MP0004957_abnormal_blastocyst_morpholog1.83175509
21MP0010307_abnormal_tumor_latency1.81565560
22MP0001929_abnormal_gametogenesis1.80310746
23MP0009053_abnormal_anal_canal1.69179506
24MP0003950_abnormal_plasma_membrane1.65441708
25MP0005076_abnormal_cell_differentiation1.65024391
26MP0002282_abnormal_trachea_morphology1.64874776
27MP0003123_paternal_imprinting1.58891481
28MP0002210_abnormal_sex_determination1.58367807
29MP0008932_abnormal_embryonic_tissue1.58111162
30MP0009697_abnormal_copulation1.56655780
31MP0003941_abnormal_skin_development1.56138298
32MP0001299_abnormal_eye_distance/1.53289924
33MP0005187_abnormal_penis_morphology1.51871175
34MP0005503_abnormal_tendon_morphology1.51255336
35MP0003566_abnormal_cell_adhesion1.49369647
36MP0001672_abnormal_embryogenesis/_devel1.47754026
37MP0005380_embryogenesis_phenotype1.47754026
38MP0001730_embryonic_growth_arrest1.46549595
39MP0000350_abnormal_cell_proliferation1.44252307
40MP0003984_embryonic_growth_retardation1.43135319
41MP0001293_anophthalmia1.41242160
42MP0002088_abnormal_embryonic_growth/wei1.40663473
43MP0002697_abnormal_eye_size1.38851596
44MP0004233_abnormal_muscle_weight1.37069641
45MP0005083_abnormal_biliary_tract1.34476714
46MP0003698_abnormal_male_reproductive1.32314547
47MP0010368_abnormal_lymphatic_system1.30185653
48MP0009703_decreased_birth_body1.29911824
49MP0003091_abnormal_cell_migration1.29091998
50MP0005023_abnormal_wound_healing1.27110292
51MP0001697_abnormal_embryo_size1.25911419
52MP0005275_abnormal_skin_tensile1.25896673
53MP0003937_abnormal_limbs/digits/tail_de1.25078928
54MP0001145_abnormal_male_reproductive1.24605940
55MP0004185_abnormal_adipocyte_glucose1.24089012
56MP0000569_abnormal_digit_pigmentation1.22570355
57MP0002086_abnormal_extraembryonic_tissu1.21679025
58MP0003890_abnormal_embryonic-extraembry1.19283387
59MP0002084_abnormal_developmental_patter1.18688821
60MP0009672_abnormal_birth_weight1.18056928
61MP0004197_abnormal_fetal_growth/weight/1.17260774
62MP0005508_abnormal_skeleton_morphology1.17130868
63MP0002085_abnormal_embryonic_tissue1.16624850
64MP0003115_abnormal_respiratory_system1.15444653
65MP0000653_abnormal_sex_gland1.15210406
66MP0004145_abnormal_muscle_electrophysio1.13333587
67MP0000749_muscle_degeneration1.11929630
68MP0001119_abnormal_female_reproductive1.08277072
69MP0003656_abnormal_erythrocyte_physiolo1.07533587
70MP0000733_abnormal_muscle_development1.07413551
71MP0006054_spinal_hemorrhage1.06687899
72MP0000751_myopathy1.06366981
73MP0003121_genomic_imprinting1.04334058
74MP0004808_abnormal_hematopoietic_stem1.03267804
75MP0000049_abnormal_middle_ear1.02814675
76MP0010630_abnormal_cardiac_muscle1.01871645
77MP0000432_abnormal_head_morphology0.99765267
78MP0004084_abnormal_cardiac_muscle0.99597026
79MP0004087_abnormal_muscle_fiber0.99358181
80MP0003279_aneurysm0.99337134
81MP0003755_abnormal_palate_morphology0.98756363
82MP0002177_abnormal_outer_ear0.97725963
83MP0003385_abnormal_body_wall0.97476072
84MP0002092_abnormal_eye_morphology0.97368764
85MP0002249_abnormal_larynx_morphology0.97342222
86MP0002233_abnormal_nose_morphology0.96700744
87MP0000490_abnormal_crypts_of0.96575849
88MP0000747_muscle_weakness0.94823900
89MP0010234_abnormal_vibrissa_follicle0.94795234
90MP0003718_maternal_effect0.94623213
91MP0003828_pulmonary_edema0.94521115
92MP0004272_abnormal_basement_membrane0.93882800
93MP0000428_abnormal_craniofacial_morphol0.92389785
94MP0008789_abnormal_olfactory_epithelium0.92244892
95MP0002161_abnormal_fertility/fecundity0.92060199
96MP0004215_abnormal_myocardial_fiber0.89688664
97MP0002080_prenatal_lethality0.89374650
98MP0002269_muscular_atrophy0.89189366
99MP0003861_abnormal_nervous_system0.88183944
100MP0002108_abnormal_muscle_morphology0.87667745
101MP0009250_abnormal_appendicular_skeleto0.86438317
102MP0000767_abnormal_smooth_muscle0.86384984
103MP0000537_abnormal_urethra_morphology0.86015760
104MP0003935_abnormal_craniofacial_develop0.85864166
105MP0005621_abnormal_cell_physiology0.85585207
106MP0005248_abnormal_Harderian_gland0.85364029
107MP0005620_abnormal_muscle_contractility0.85348241
108MP0002925_abnormal_cardiovascular_devel0.84916853
109MP0002932_abnormal_joint_morphology0.84746558
110MP0001958_emphysema0.83339247
111MP0001529_abnormal_vocalization0.82721350
112MP0002102_abnormal_ear_morphology0.81823459
113MP0000313_abnormal_cell_death0.80846261
114MP0005623_abnormal_meninges_morphology0.80651137
115MP0003448_altered_tumor_morphology0.80400414
116MP0004130_abnormal_muscle_cell0.80210425
117MP0003119_abnormal_digestive_system0.79011605
118MP0000266_abnormal_heart_morphology0.78776653
119MP0002972_abnormal_cardiac_muscle0.78678555
120MP0000759_abnormal_skeletal_muscle0.78368608
121MP0002653_abnormal_ependyma_morphology0.77843838
122MP0003453_abnormal_keratinocyte_physiol0.77587161
123MP0002089_abnormal_postnatal_growth/wei0.76180831
124MP0001286_abnormal_eye_development0.76079539
125MP0005389_reproductive_system_phenotype0.75567015
126MP0003567_abnormal_fetal_cardiomyocyte0.75543608
127MP0001175_abnormal_lung_morphology0.75420349
128MP0001915_intracranial_hemorrhage0.74261562
129MP0002109_abnormal_limb_morphology0.74168303
130MP0009384_cardiac_valve_regurgitation0.74003740
131MP0002009_preneoplasia0.73889423
132MP0002081_perinatal_lethality0.73375998
133MP0008770_decreased_survivor_rate0.73307254
134MP0005390_skeleton_phenotype0.72138699
135MP0002111_abnormal_tail_morphology0.71863006
136MP0000163_abnormal_cartilage_morphology0.71572892
137MP0002113_abnormal_skeleton_development0.71145690
138MP0002115_abnormal_skeleton_extremities0.69574627
139MP0004134_abnormal_chest_morphology0.69132157
140MP0000762_abnormal_tongue_morphology0.68966055
141MP0003942_abnormal_urinary_system0.68929272

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.39837184
2Dynein arm defect of respiratory motile cilia (HP:0012255)3.30651642
3Absent/shortened dynein arms (HP:0200106)3.30651642
4Thyroid carcinoma (HP:0002890)3.08925461
5Neonatal short-limb short stature (HP:0008921)3.07908824
6Dysmetric saccades (HP:0000641)3.02366001
7Missing ribs (HP:0000921)2.96295144
8Osteomalacia (HP:0002749)2.93059844
9Chromsome breakage (HP:0040012)2.88247155
10Protrusio acetabuli (HP:0003179)2.82066592
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.79542330
12Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71399560
13Short 4th metacarpal (HP:0010044)2.71399560
14Abnormal respiratory motile cilium physiology (HP:0012261)2.69325559
15Medulloblastoma (HP:0002885)2.62527293
16Neoplasm of the small intestine (HP:0100833)2.62443635
17Nemaline bodies (HP:0003798)2.61174954
18Impulsivity (HP:0100710)2.56687734
19Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.52852140
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.48757828
21Biliary tract neoplasm (HP:0100574)2.46788933
22Selective tooth agenesis (HP:0001592)2.42745745
23Rhinitis (HP:0012384)2.38814416
24Muscle fiber inclusion bodies (HP:0100299)2.38738930
25Chronic bronchitis (HP:0004469)2.33034790
26Premature rupture of membranes (HP:0001788)2.31057376
27Mesomelia (HP:0003027)2.28190832
28Heterotopia (HP:0002282)2.26072556
29Short middle phalanx of the 5th finger (HP:0004220)2.26070006
30Abnormal respiratory epithelium morphology (HP:0012253)2.25342829
31Abnormal respiratory motile cilium morphology (HP:0005938)2.25342829
32Acute myeloid leukemia (HP:0004808)2.24777706
33Termporal pattern (HP:0011008)2.19982229
34Insidious onset (HP:0003587)2.19982229
35Bladder carcinoma (HP:0002862)2.18334823
36Bladder neoplasm (HP:0009725)2.18334823
37Ectopic kidney (HP:0000086)2.17490396
38Short nail (HP:0001799)2.17315033
39Hypochromic microcytic anemia (HP:0004840)2.14971350
40Curly hair (HP:0002212)2.12686042
41Skull defect (HP:0001362)2.12507000
42Meckel diverticulum (HP:0002245)2.12420232
43Subacute progressive viral hepatitis (HP:0006572)2.12415057
44Subaortic stenosis (HP:0001682)2.10656659
45Abnormality of the left ventricular outflow tract (HP:0011103)2.10656659
46Vertebral arch anomaly (HP:0008438)2.10319230
47Abnormal spermatogenesis (HP:0008669)2.09787500
48Abnormality of chromosome stability (HP:0003220)2.08776071
49Cubitus valgus (HP:0002967)2.08535743
50Cystic hygroma (HP:0000476)2.08485364
51Aortic aneurysm (HP:0004942)2.07637345
52Hepatoblastoma (HP:0002884)2.06720810
53Ankle contracture (HP:0006466)2.04918036
54Infertility (HP:0000789)2.04354428
55Rhizomelia (HP:0008905)2.03216824
56Limited elbow extension (HP:0001377)2.03088729
57Abnormality of the ileum (HP:0001549)2.02981917
58Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02953322
59Adactyly (HP:0009776)2.01017402
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.00899543
61Papillary thyroid carcinoma (HP:0002895)1.98700328
62Supernumerary spleens (HP:0009799)1.94463071
63Neoplasm of the rectum (HP:0100743)1.94131793
64Overgrowth (HP:0001548)1.94097864
65Pheochromocytoma (HP:0002666)1.91472560
66Broad palm (HP:0001169)1.90693223
67Shoulder girdle muscle weakness (HP:0003547)1.90059521
68Fibular hypoplasia (HP:0003038)1.89723193
69Birth length less than 3rd percentile (HP:0003561)1.88823708
70Complete atrioventricular canal defect (HP:0001674)1.88487379
71Abnormality of the anterior horn cell (HP:0006802)1.88181104
72Degeneration of anterior horn cells (HP:0002398)1.88181104
7311 pairs of ribs (HP:0000878)1.87837673
74Neoplasm of the oral cavity (HP:0100649)1.87402739
75Nephroblastoma (Wilms tumor) (HP:0002667)1.87331568
76Coronal craniosynostosis (HP:0004440)1.87071239
77Abnormal ciliary motility (HP:0012262)1.86830116
78Aplasia/Hypoplasia of the sternum (HP:0006714)1.86346330
79Syringomyelia (HP:0003396)1.85931693
80Spinal cord lesions (HP:0100561)1.85931693
81Uterine leiomyosarcoma (HP:0002891)1.85646766
82Leiomyosarcoma (HP:0100243)1.85646766
83Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.85249219
84Absent epiphyses (HP:0010577)1.85249219
85Abnormality of the musculature of the pelvis (HP:0001469)1.84413927
86Abnormality of the hip-girdle musculature (HP:0001445)1.84413927
87Abnormality of the right ventricle (HP:0001707)1.84387945
88Acanthocytosis (HP:0001927)1.84125201
89Ankyloglossia (HP:0010296)1.84026229
90Pelvic girdle muscle weakness (HP:0003749)1.82978401
91Malignant gastrointestinal tract tumors (HP:0006749)1.82885844
92Gastrointestinal carcinoma (HP:0002672)1.82885844
93Abnormality of the 4th metacarpal (HP:0010012)1.82447030
94Type 1 muscle fiber predominance (HP:0003803)1.82320852
95Increased nuchal translucency (HP:0010880)1.81863214
96Absent radius (HP:0003974)1.81861076
97Uterine neoplasm (HP:0010784)1.81355938
98Rimmed vacuoles (HP:0003805)1.81327337
99Neoplasm of the thyroid gland (HP:0100031)1.81315647
100Embryonal renal neoplasm (HP:0011794)1.80132650
101Duodenal stenosis (HP:0100867)1.79698501
102Small intestinal stenosis (HP:0012848)1.79698501
103Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.79401901
104Fair hair (HP:0002286)1.79325985
105Cupped ribs (HP:0000887)1.79092770
106High pitched voice (HP:0001620)1.78054742
107Aplasia/Hypoplasia of the scapulae (HP:0006713)1.76263548
108Hypoplastic scapulae (HP:0000882)1.76263548
109Abnormality of the heme biosynthetic pathway (HP:0010472)1.74751959
110Male infertility (HP:0003251)1.73278980
111Insomnia (HP:0100785)1.71595777
112Abnormality of the septum pellucidum (HP:0007375)1.70960922
113Broad alveolar ridges (HP:0000187)1.70797020
114Wrist flexion contracture (HP:0001239)1.70564668
115Broad distal phalanx of finger (HP:0009836)1.70421445
116Aortic dissection (HP:0002647)1.70221870
117Poikilocytosis (HP:0004447)1.69602094
118Dislocated radial head (HP:0003083)1.69274808
119Microglossia (HP:0000171)1.69221640
120Spastic diplegia (HP:0001264)1.69195048
121Short ribs (HP:0000773)1.68538122
122Short humerus (HP:0005792)1.66693466
123Rhabdomyosarcoma (HP:0002859)1.65846749
124Abnormality of incisor morphology (HP:0011063)1.65563957
125Absent forearm bone (HP:0003953)1.65522019
126Aplasia involving forearm bones (HP:0009822)1.65522019
127Soft skin (HP:0000977)1.65162995
128Short middle phalanx of finger (HP:0005819)1.64761668
129Hypoplastic labia majora (HP:0000059)1.64693516
130Cervical subluxation (HP:0003308)1.64484141
131Obsessive-compulsive behavior (HP:0000722)1.63950816
132Long eyelashes (HP:0000527)1.63276470
133Sloping forehead (HP:0000340)1.62997046
134Synostosis of carpal bones (HP:0005048)1.62768870
135Deviation of the thumb (HP:0009603)1.62619919
136Abnormality of the proximal phalanges of the hand (HP:0009834)1.62359960
137Transitional cell carcinoma of the bladder (HP:0006740)1.62256732
138Aplasia/hypoplasia of the humerus (HP:0006507)1.62012263
139Long clavicles (HP:0000890)1.61575248
140Broad toe (HP:0001837)1.61259380
141Osteolytic defects of the hand bones (HP:0009699)1.60577844
142Osteolytic defects of the phalanges of the hand (HP:0009771)1.60577844
143Abnormality of the ischium (HP:0003174)1.60053681
144Short femoral neck (HP:0100864)1.58759261
145Abnormality of chromosome segregation (HP:0002916)1.58392219
146Bicuspid aortic valve (HP:0001647)1.58184026
147Cortical dysplasia (HP:0002539)1.58155971
148Convex nasal ridge (HP:0000444)1.58106354
149Abnormality of the labia majora (HP:0012881)1.57747803
150Metaphyseal cupping (HP:0003021)1.57376358
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.57369049
152Drooling (HP:0002307)1.57108973
153Atrioventricular canal defect (HP:0006695)1.57036746
154Azoospermia (HP:0000027)1.56646380
155Metatarsus adductus (HP:0001840)1.56520194
156Deep philtrum (HP:0002002)1.56160700
157Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.55982032
158Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.55770822
159Exercise-induced muscle cramps (HP:0003710)1.55662488
160Difficulty running (HP:0009046)1.54474401
161Broad metatarsal (HP:0001783)1.54437799
162Hammertoe (HP:0001765)1.54383438
163Abdominal situs inversus (HP:0003363)1.53747618
164Abnormality of abdominal situs (HP:0011620)1.53747618
165Protruding tongue (HP:0010808)1.52668850
166Mitral regurgitation (HP:0001653)1.52628179
167Freckling (HP:0001480)1.50944523
168Pulmonic stenosis (HP:0001642)1.50346492
169Glioma (HP:0009733)1.49640350
170Colon cancer (HP:0003003)1.49611634
171Abnormality of the astrocytes (HP:0100707)1.48424939
172Astrocytoma (HP:0009592)1.48424939
173Abnormal hair whorl (HP:0010721)1.48351572
174Neoplasm of striated muscle (HP:0009728)1.48168287
175Melanocytic nevus (HP:0000995)1.47919792

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.37100647
2CDK123.22808625
3EIF2AK13.14868700
4PDK32.92146654
5PDK42.92146654
6CDC72.78155981
7NEK22.56861032
8KSR22.48677842
9TTK2.45709262
10ZAK2.43264484
11KSR12.41777555
12PDK22.25403613
13WEE12.18153872
14MKNK22.14451938
15STK102.05709366
16TESK12.00055857
17WNK11.99795256
18STK31.92807378
19PLK41.90850486
20MELK1.90729203
21TNIK1.81093467
22DYRK31.72620723
23RAF11.72619587
24CAMK1G1.70293001
25LATS11.69690635
26CHEK21.66658763
27OBSCN1.62387208
28PNCK1.61233662
29PLK11.59258032
30SGK21.51486505
31CDK81.49232945
32FGFR31.49070924
33TSSK61.47459870
34TLK11.42613182
35STK38L1.41399721
36CASK1.36927759
37TGFBR21.36486760
38CAMK1D1.36420950
39RPS6KA41.35218790
40AURKB1.34536627
41ATR1.31703545
42BRD41.30349194
43MAP3K41.25000173
44MAP3K21.24642910
45ACVR1B1.21536554
46SGK31.20784853
47PLK31.18406492
48CDK71.17609296
49TGFBR11.14286333
50BRSK21.12979834
51EIF2AK21.11643356
52PIM11.09473491
53EPHA21.09254577
54CDK41.09169023
55MST41.08009619
56STK41.05153860
57SRPK11.05029401
58TTN1.04200481
59CDK91.00769561
60MAP3K90.99853159
61NUAK10.98813217
62NEK90.98516528
63CHEK10.98228570
64TRPM70.97382949
65ERBB30.96461738
66PRPF4B0.94584445
67FGFR10.94274956
68CHUK0.93582155
69EEF2K0.93411733
70ATM0.93255800
71PDGFRB0.93065333
72MAP3K100.92621015
73MTOR0.89283405
74BMX0.86535782
75CLK10.86397734
76CDK60.84723908
77MOS0.84592725
78MAP3K80.82957558
79TAF10.81416321
80AURKA0.80782508
81DDR20.80487316
82PRKD30.79357535
83SGK2230.79237334
84SGK4940.79237334
85TAOK10.78714598
86PDGFRA0.78297592
87PBK0.77984648
88MKNK10.74231164
89YES10.74095485
90BMPR1B0.72143592
91IRAK30.70086061
92PASK0.69084249
93MAP3K50.69056331
94NEK10.68824736
95ERBB40.66632704
96MARK10.65546522
97NLK0.65525642
98RPS6KB20.64889154
99TRIM280.64106879
100MAP2K30.62590931
101PAK40.61745780
102MAP3K30.61167849
103MAP3K140.61018144
104NTRK10.60658520
105DMPK0.59233446
106VRK10.58567089
107BRAF0.58030937
108ICK0.56121408
109EPHA30.54819702
110EIF2AK30.54220536
111TAOK20.53780137
112BRSK10.51987347
113MAP2K10.51011029
114CDK20.50696007
115FGFR20.50271578
116PAK20.49132512
117CDK10.48822778
118CSNK1G20.48001323
119SGK10.46724640
120STK240.46592872
121MAPKAPK30.45490935
122ERN10.45386570
123CSNK1G10.44106898
124PTK2B0.43169715
125RET0.42909208
126LATS20.42558609
127AKT20.42239250
128DYRK1B0.40164024
129MAP3K10.39772809
130MAPK100.39271933
131CAMK40.39050179
132JAK30.38718699
133MAP2K40.38533970
134MAP3K60.36909752
135FLT30.36436408
136EPHB20.35920965
137AKT30.34490438
138MAPKAPK20.33955960
139PIM20.33716745
140BCR0.32646524
141MET0.32106351
142AKT10.31208121
143MARK30.30732452
144FGFR40.30338562
145RPS6KA50.29312881

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041103.13952429
2Vitamin B6 metabolism_Homo sapiens_hsa007502.55534272
3DNA replication_Homo sapiens_hsa030302.55028437
4RNA transport_Homo sapiens_hsa030132.51161781
5Fanconi anemia pathway_Homo sapiens_hsa034602.33065661
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17575416
7p53 signaling pathway_Homo sapiens_hsa041152.08829258
8Homologous recombination_Homo sapiens_hsa034402.00073087
9Basal transcription factors_Homo sapiens_hsa030221.99447288
10Base excision repair_Homo sapiens_hsa034101.99162903
11Mismatch repair_Homo sapiens_hsa034301.95357409
12Systemic lupus erythematosus_Homo sapiens_hsa053221.90671406
13One carbon pool by folate_Homo sapiens_hsa006701.90275584
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80130362
15Selenocompound metabolism_Homo sapiens_hsa004501.78663145
16Endometrial cancer_Homo sapiens_hsa052131.77131000
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.67068188
18mRNA surveillance pathway_Homo sapiens_hsa030151.65843678
19Non-homologous end-joining_Homo sapiens_hsa034501.65332437
20Spliceosome_Homo sapiens_hsa030401.65265336
21Circadian rhythm_Homo sapiens_hsa047101.64809705
22Renal cell carcinoma_Homo sapiens_hsa052111.63464098
23MicroRNAs in cancer_Homo sapiens_hsa052061.57283840
24Small cell lung cancer_Homo sapiens_hsa052221.56381685
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.52975622
26Legionellosis_Homo sapiens_hsa051341.51118540
27RNA degradation_Homo sapiens_hsa030181.50810045
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.49487425
29TGF-beta signaling pathway_Homo sapiens_hsa043501.44671853
30Nucleotide excision repair_Homo sapiens_hsa034201.44222915
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38443310
32Melanoma_Homo sapiens_hsa052181.35260438
33Viral carcinogenesis_Homo sapiens_hsa052031.32867047
34ErbB signaling pathway_Homo sapiens_hsa040121.31142298
35Non-small cell lung cancer_Homo sapiens_hsa052231.30130238
36Adherens junction_Homo sapiens_hsa045201.27073272
37Malaria_Homo sapiens_hsa051441.25598905
38Herpes simplex infection_Homo sapiens_hsa051681.25197266
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.21721006
40Basal cell carcinoma_Homo sapiens_hsa052171.21666037
41HTLV-I infection_Homo sapiens_hsa051661.13884465
42Hippo signaling pathway_Homo sapiens_hsa043901.13130688
43Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12938504
44Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12507562
45Pyrimidine metabolism_Homo sapiens_hsa002401.11860427
46Glioma_Homo sapiens_hsa052141.10684236
47Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10258594
48ECM-receptor interaction_Homo sapiens_hsa045121.09584798
49Hedgehog signaling pathway_Homo sapiens_hsa043401.08085714
50Notch signaling pathway_Homo sapiens_hsa043301.06580549
51Prolactin signaling pathway_Homo sapiens_hsa049171.06319260
52Dorso-ventral axis formation_Homo sapiens_hsa043201.04853883
53mTOR signaling pathway_Homo sapiens_hsa041501.04141122
54Inositol phosphate metabolism_Homo sapiens_hsa005621.03927384
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03886954
56Transcriptional misregulation in cancer_Homo sapiens_hsa052021.03140292
57Wnt signaling pathway_Homo sapiens_hsa043100.99988814
58Epstein-Barr virus infection_Homo sapiens_hsa051690.99714645
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.98672643
60Apoptosis_Homo sapiens_hsa042100.97961748
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93624317
62Antigen processing and presentation_Homo sapiens_hsa046120.93488861
63Bladder cancer_Homo sapiens_hsa052190.92329548
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91247496
65Tight junction_Homo sapiens_hsa045300.91084829
66Oocyte meiosis_Homo sapiens_hsa041140.90076646
67Dilated cardiomyopathy_Homo sapiens_hsa054140.88200436
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.87706282
69Gap junction_Homo sapiens_hsa045400.83977862
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.82139788
71Long-term potentiation_Homo sapiens_hsa047200.81787452
72Proteoglycans in cancer_Homo sapiens_hsa052050.81395478
73Acute myeloid leukemia_Homo sapiens_hsa052210.81170830
74Insulin signaling pathway_Homo sapiens_hsa049100.80489838
75Regulation of autophagy_Homo sapiens_hsa041400.80115545
76Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80096391
77Measles_Homo sapiens_hsa051620.79565526
78TNF signaling pathway_Homo sapiens_hsa046680.79442210
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.77638947
80Influenza A_Homo sapiens_hsa051640.77618892
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76735787
82RNA polymerase_Homo sapiens_hsa030200.76477197
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75378322
84Focal adhesion_Homo sapiens_hsa045100.74933469
85Toxoplasmosis_Homo sapiens_hsa051450.74028016
86Hepatitis B_Homo sapiens_hsa051610.73817503
87Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73415277
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71773566
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70640367
90Leishmaniasis_Homo sapiens_hsa051400.70476970
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70267324
92Estrogen signaling pathway_Homo sapiens_hsa049150.69093925
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69079645
94Chronic myeloid leukemia_Homo sapiens_hsa052200.68972468
95Proteasome_Homo sapiens_hsa030500.68851131
96Long-term depression_Homo sapiens_hsa047300.68737107
97AMPK signaling pathway_Homo sapiens_hsa041520.68719454
98Pentose phosphate pathway_Homo sapiens_hsa000300.68021206
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67472018
100Lysine degradation_Homo sapiens_hsa003100.67346981
101Graft-versus-host disease_Homo sapiens_hsa053320.66609740
102Prostate cancer_Homo sapiens_hsa052150.65814700
103Pancreatic cancer_Homo sapiens_hsa052120.64095211
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63062966
105Pathways in cancer_Homo sapiens_hsa052000.63031602
106Rap1 signaling pathway_Homo sapiens_hsa040150.62969102
107Purine metabolism_Homo sapiens_hsa002300.62856647
108Viral myocarditis_Homo sapiens_hsa054160.62637301
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61142638
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.57963211
111FoxO signaling pathway_Homo sapiens_hsa040680.57546101
112Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57191483
113HIF-1 signaling pathway_Homo sapiens_hsa040660.56873807
114Type II diabetes mellitus_Homo sapiens_hsa049300.55938339
115MAPK signaling pathway_Homo sapiens_hsa040100.55881285
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54517292
117Amoebiasis_Homo sapiens_hsa051460.54283740
118Hematopoietic cell lineage_Homo sapiens_hsa046400.52831342
119Melanogenesis_Homo sapiens_hsa049160.50482404
120Axon guidance_Homo sapiens_hsa043600.49849862
121Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49660693
122Steroid biosynthesis_Homo sapiens_hsa001000.48755188
123Arachidonic acid metabolism_Homo sapiens_hsa005900.48580123
124Alcoholism_Homo sapiens_hsa050340.48297898
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48174611
126Complement and coagulation cascades_Homo sapiens_hsa046100.47366038
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47339004
128Colorectal cancer_Homo sapiens_hsa052100.45871078
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.45173799
130Glutathione metabolism_Homo sapiens_hsa004800.44899918
131Ras signaling pathway_Homo sapiens_hsa040140.43784142
132Shigellosis_Homo sapiens_hsa051310.43625775
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.43097673
134Thyroid cancer_Homo sapiens_hsa052160.42987052
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42465771
136Choline metabolism in cancer_Homo sapiens_hsa052310.41022946
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38821352
138Salmonella infection_Homo sapiens_hsa051320.38536514
139Phagosome_Homo sapiens_hsa041450.38434486
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37768858
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.37085309
142Staphylococcus aureus infection_Homo sapiens_hsa051500.36775158
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36250170
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35550930
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.34527917

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