FBXO31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the F-box family. Members are classified into three classes according to the substrate interaction domain, FBW for WD40 repeats, FBL for leucing-rich repeats, and FBXO for other domains. This protein, classified into the last category because of the lack of a recognizable substrate binding domain, has been proposed to be a component of the SCF ubiquitination complex. It is thought to bind and recruit substrate for ubiquitination and degradation. This protein may have a role in regulating the cell cycle as well as dendrite growth and neuronal migration. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)4.61822336
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.55476288
3regulation of cholesterol homeostasis (GO:2000188)4.21777165
4neuronal action potential propagation (GO:0019227)4.13176117
5locomotory exploration behavior (GO:0035641)4.10732657
6glutamate secretion (GO:0014047)4.00275287
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.98073682
8regulation of synapse maturation (GO:0090128)3.95234989
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.82709115
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.74678512
11regulation of synapse structural plasticity (GO:0051823)3.74513075
12vocalization behavior (GO:0071625)3.73164212
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.72450594
14synaptic vesicle exocytosis (GO:0016079)3.66302221
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.66014378
16negative regulation of fibrinolysis (GO:0051918)3.62936808
17synaptic vesicle docking involved in exocytosis (GO:0016081)3.60310878
18regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.57922785
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.57472691
20regulation of synaptic vesicle exocytosis (GO:2000300)3.56088743
21regulation of glutamate receptor signaling pathway (GO:1900449)3.48540524
22protein carboxylation (GO:0018214)3.48508633
23peptidyl-glutamic acid carboxylation (GO:0017187)3.48508633
24cell communication by electrical coupling (GO:0010644)3.45969059
25regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.42469609
26activation of protein kinase A activity (GO:0034199)3.42120242
27regulation of synaptic vesicle transport (GO:1902803)3.40003690
28regulation of neuronal synaptic plasticity (GO:0048168)3.36109676
29regulation of ARF protein signal transduction (GO:0032012)3.36094144
30neurotransmitter secretion (GO:0007269)3.34991595
31intestinal cholesterol absorption (GO:0030299)3.33842360
32neurotransmitter-gated ion channel clustering (GO:0072578)3.32830829
33cerebellar granule cell differentiation (GO:0021707)3.31222359
34plasma membrane repair (GO:0001778)3.28607189
35carnitine shuttle (GO:0006853)3.24508967
36regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.21581610
37gamma-aminobutyric acid transport (GO:0015812)3.20406152
38dicarboxylic acid biosynthetic process (GO:0043650)3.20005360
39cellular sodium ion homeostasis (GO:0006883)3.19046575
40very-low-density lipoprotein particle assembly (GO:0034379)3.17983188
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.16418994
42regulation of fibrinolysis (GO:0051917)3.15800789
43protein-lipid complex assembly (GO:0065005)3.15373794
44cell communication involved in cardiac conduction (GO:0086065)3.14883954
45regulation of cholesterol biosynthetic process (GO:0045540)3.12769326
46protein localization to synapse (GO:0035418)3.11997061
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11309449
48regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.11100157
49sarcoplasmic reticulum calcium ion transport (GO:0070296)3.10262631
50sodium ion export (GO:0071436)3.09696905
51negative regulation of potassium ion transmembrane transport (GO:1901380)3.09479063
52exploration behavior (GO:0035640)3.07475405
53regulation of long-term neuronal synaptic plasticity (GO:0048169)3.07472352
54creatine metabolic process (GO:0006600)3.07132152
55neuromuscular process controlling posture (GO:0050884)3.04589822
56lung epithelium development (GO:0060428)3.03261717
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.02763110
58layer formation in cerebral cortex (GO:0021819)3.02444285
59proline transport (GO:0015824)3.02196855
60aspartate family amino acid catabolic process (GO:0009068)3.00542827
61fatty acid transmembrane transport (GO:1902001)2.98374484
62regulation of membrane repolarization (GO:0060306)2.97731435
63membrane depolarization during action potential (GO:0086010)2.97690949
64plasma lipoprotein particle assembly (GO:0034377)2.97097065
65cellular potassium ion homeostasis (GO:0030007)2.96904949
66regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.96876576
67regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.94962061
682-oxoglutarate metabolic process (GO:0006103)2.92508031
69response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.91748264
70lysine catabolic process (GO:0006554)2.89449762
71lysine metabolic process (GO:0006553)2.89449762
72glycine transport (GO:0015816)2.88558214
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.83845389
74L-phenylalanine metabolic process (GO:0006558)2.82358062
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82358062
76regulation of calcium ion transmembrane transport (GO:1903169)2.81230324
77regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81230324
78neuromuscular process controlling balance (GO:0050885)2.80528111
79cholesterol efflux (GO:0033344)2.80396810
80diacylglycerol metabolic process (GO:0046339)2.79993875
81dendritic spine morphogenesis (GO:0060997)2.78744275
82dicarboxylic acid catabolic process (GO:0043649)2.78621795
83erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.78069075
84L-phenylalanine catabolic process (GO:0006559)2.78069075
85regulation of sodium ion transmembrane transporter activity (GO:2000649)2.77626378
86regulation of protein activation cascade (GO:2000257)2.77585793
87cardiac muscle contraction (GO:0060048)2.76385633
88regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.75021537
89alanine transport (GO:0032328)2.73847802
90cellular ketone body metabolic process (GO:0046950)2.73305144
91regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72565259
92cell migration in hindbrain (GO:0021535)2.72436313
93positive regulation of triglyceride lipase activity (GO:0061365)2.72081912
94positive regulation of lipoprotein lipase activity (GO:0051006)2.72081912
95NADH metabolic process (GO:0006734)2.71704715
96tricarboxylic acid cycle (GO:0006099)2.71365216
97regulation of complement activation (GO:0030449)2.71265648
98regulation of bile acid biosynthetic process (GO:0070857)2.70725107
99positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70111316
100regulation of apoptotic cell clearance (GO:2000425)2.69233166
101synaptic transmission, glutamatergic (GO:0035249)2.68847450
102regulation of dendritic spine morphogenesis (GO:0061001)2.68808492
103regulation of cell communication by electrical coupling (GO:0010649)2.68399641
104potassium ion import (GO:0010107)2.67790651
105proline metabolic process (GO:0006560)2.67452485
106glutamate metabolic process (GO:0006536)2.67407813
107regulation of acyl-CoA biosynthetic process (GO:0050812)2.66631525
108regulation of cholesterol metabolic process (GO:0090181)2.64004390
109positive regulation of sodium ion transport (GO:0010765)2.62881454
110regulation of extracellular matrix disassembly (GO:0010715)2.62125641
111alpha-linolenic acid metabolic process (GO:0036109)2.60633675
112regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59742121
113regulation of neurotransmitter levels (GO:0001505)2.59577876
114regulation of cholesterol esterification (GO:0010872)2.57853438
115neuron cell-cell adhesion (GO:0007158)2.57552426
116neurotransmitter transport (GO:0006836)2.57134512
117positive regulation of membrane potential (GO:0045838)2.56488872
118regulation of sodium ion transmembrane transport (GO:1902305)2.56257154
119long-term memory (GO:0007616)2.56244481
120low-density lipoprotein particle clearance (GO:0034383)2.56206551
121potassium ion homeostasis (GO:0055075)2.56159594
122focal adhesion assembly (GO:0048041)2.56086772
123cell-substrate adherens junction assembly (GO:0007045)2.56086772
124regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.54577933
125regulation of ARF GTPase activity (GO:0032312)2.53943298
126regulation of ion transmembrane transporter activity (GO:0032412)2.52628472
127positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.52206246
128positive regulation of dendritic spine development (GO:0060999)2.51335920
129positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.51243858
130protein-lipid complex subunit organization (GO:0071825)2.50781158
131glycogen catabolic process (GO:0005980)2.50515114
132neuron-neuron synaptic transmission (GO:0007270)2.49802323
133regulation of glycogen (starch) synthase activity (GO:2000465)2.48655830
134cell volume homeostasis (GO:0006884)2.48627576
135positive regulation of extracellular matrix organization (GO:1903055)2.48587265
136positive regulation of potassium ion transmembrane transport (GO:1901381)2.48470307
137protein-lipid complex remodeling (GO:0034368)2.48401162
138macromolecular complex remodeling (GO:0034367)2.48401162
139plasma lipoprotein particle remodeling (GO:0034369)2.48401162
140positive regulation of synapse maturation (GO:0090129)2.48392673
141regulation of cofactor metabolic process (GO:0051193)2.47273905
142regulation of coenzyme metabolic process (GO:0051196)2.47273905
143regulation of synaptic plasticity (GO:0048167)2.47015720
144amino acid import (GO:0043090)2.46787590
145regulation of plasminogen activation (GO:0010755)2.46127621
146ventricular cardiac muscle cell action potential (GO:0086005)2.44821367
147axon ensheathment in central nervous system (GO:0032291)2.44537566
148central nervous system myelination (GO:0022010)2.44537566
149oxaloacetate metabolic process (GO:0006107)2.44311258
150adherens junction assembly (GO:0034333)2.42843484
151negative regulation of cholesterol transport (GO:0032375)2.42190804
152negative regulation of sterol transport (GO:0032372)2.42190804
153negative regulation of fatty acid transport (GO:2000192)2.42136224
154triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.39315972
155mannose metabolic process (GO:0006013)2.39069055
156insulin-like growth factor receptor signaling pathway (GO:0048009)2.38846220
157embryonic retina morphogenesis in camera-type eye (GO:0060059)2.37626744
158plasma lipoprotein particle organization (GO:0071827)2.37180740
159macroautophagy (GO:0016236)2.36582135
160positive regulation of fatty acid biosynthetic process (GO:0045723)2.35110034
161regulation of extracellular matrix organization (GO:1903053)2.34475486
162neuronal ion channel clustering (GO:0045161)2.33903366
163L-amino acid import (GO:0043092)2.33538596
164low-density lipoprotein particle remodeling (GO:0034374)2.32139928

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80193094
2* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.60296191
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.84782494
4RARB_27405468_Chip-Seq_BRAIN_Mouse2.84281437
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.79616699
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.59818858
7DROSHA_22980978_ChIP-Seq_HELA_Human2.49052882
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42490946
9REST_21632747_ChIP-Seq_MESCs_Mouse2.41787334
10* RXR_22158963_ChIP-Seq_LIVER_Mouse2.37430093
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.36440523
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.30011320
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.27765875
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.26935576
15EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25886471
16* REST_18959480_ChIP-ChIP_MESCs_Mouse2.25841447
17SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21612959
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21086336
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21086336
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.16514850
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11503853
22FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.10192554
23ERG_21242973_ChIP-ChIP_JURKAT_Human2.05162817
24THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.97403233
25* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.95884254
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.95759860
27RACK7_27058665_Chip-Seq_MCF-7_Human1.93142654
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.90611801
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86358874
30GBX2_23144817_ChIP-Seq_PC3_Human1.85571171
31* LXR_22158963_ChIP-Seq_LIVER_Mouse1.84303547
32SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.82527292
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.80162877
34* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.77145890
35SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.76925230
36* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.75315384
37ZNF263_19887448_ChIP-Seq_K562_Human1.74983565
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.71870159
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64166360
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62479497
41* TCF7_22412390_ChIP-Seq_EML_Mouse1.59019433
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58887008
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.58807173
44* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.55164001
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.55063805
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54894154
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.54198087
48AR_21572438_ChIP-Seq_LNCaP_Human1.54102655
49CTCF_27219007_Chip-Seq_Bcells_Human1.50892949
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.50796994
51KDM2B_26808549_Chip-Seq_K562_Human1.48620511
52UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48242320
53TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.45950260
54ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45520592
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.45046658
56CLOCK_20551151_ChIP-Seq_293T_Human1.38835909
57RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38144462
58LXR_22292898_ChIP-Seq_THP-1_Human1.37437763
59ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35844967
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.35322672
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.34276048
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30807737
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.29963513
64ZNF274_21170338_ChIP-Seq_K562_Hela1.24650421
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.24025104
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23718401
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.23131063
68VDR_21846776_ChIP-Seq_THP-1_Human1.21862690
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.21723653
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21412973
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.18801653
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18418122
73GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17308321
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17302156
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.16367252
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.15462395
77TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14708088
78TET1_21490601_ChIP-Seq_MESCs_Mouse1.13735407
79* KLF4_19829295_ChIP-Seq_ESCs_Human1.12458411
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11942284
81TP53_22127205_ChIP-Seq_IMR90_Human1.11094364
82SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.10602794
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.10536867
84RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.09736868
85* RUNX1_27514584_Chip-Seq_MCF-7_Human1.08880674
86* MYC_22102868_ChIP-Seq_BL_Human1.08873631
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08556379
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07326747
89* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07150060
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06444830
91SMC4_20622854_ChIP-Seq_HELA_Human1.06191840
92TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06008685
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.05904972
94IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04191081
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02400945
96AR_19668381_ChIP-Seq_PC3_Human1.02197682
97CREB1_26743006_Chip-Seq_LNCaP_Human1.01710571
98TP53_23651856_ChIP-Seq_MEFs_Mouse1.01324286
99ELF1_20517297_ChIP-Seq_JURKAT_Human1.00828914
100RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00415851
101SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00323438
102GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.99528842
103ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99175819
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.98795784
105BCOR_27268052_Chip-Seq_Bcells_Human0.98769933
106STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98665411
107KDM2B_26808549_Chip-Seq_DND41_Human0.96663685
108* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95074669
109MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.94643837
110CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94635604
111EP300_21415370_ChIP-Seq_HL-1_Mouse0.94163100
112P68_20966046_ChIP-Seq_HELA_Human0.93823559
113CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91721514
114OCT4_19829295_ChIP-Seq_ESCs_Human0.91520736
115* TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91079639
116SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89766703
117* SMAD4_21799915_ChIP-Seq_A2780_Human0.87606421
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87099466
119SA1_27219007_Chip-Seq_Bcells_Human0.86561635
120TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.86546639
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.85925049
122TBX20_22080862_ChIP-Seq_HEART_Mouse0.84401371
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.84401371
124* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.84367273
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84076840
126SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83462382
127P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80932144
128* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.80924177
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80624098
130CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79653774
131ZFP281_27345836_Chip-Seq_ESCs_Mouse0.77503985
132TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.77254703
133* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.76816084
134CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76713212
135TP63_22573176_ChIP-Seq_HFKS_Human0.74725279
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.72688385
137AR_25329375_ChIP-Seq_VCAP_Human0.72483890
138DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.71908588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.11731726
2MP0002837_dystrophic_cardiac_calcinosis3.35764253
3MP0003646_muscle_fatigue3.26323232
4MP0003880_abnormal_central_pattern3.18980209
5MP0000751_myopathy3.18534254
6MP0004270_analgesia3.16589229
7MP0003635_abnormal_synaptic_transmissio2.98128054
8MP0002822_catalepsy2.89954693
9MP0005451_abnormal_body_composition2.50510430
10MP0003123_paternal_imprinting2.43288390
11MP0004145_abnormal_muscle_electrophysio2.37908453
12MP0004130_abnormal_muscle_cell2.37581999
13MP0009745_abnormal_behavioral_response2.36403890
14MP0005085_abnormal_gallbladder_physiolo2.31274515
15MP0002139_abnormal_hepatobiliary_system2.28048082
16MP0003705_abnormal_hypodermis_morpholog2.28024600
17MP0002063_abnormal_learning/memory/cond2.27147626
18MP0003122_maternal_imprinting2.22557101
19MP0001968_abnormal_touch/_nociception2.20380918
20MP0002064_seizures2.19963361
21MP0002089_abnormal_postnatal_growth/wei2.19254832
22MP0003172_abnormal_lysosome_physiology2.17336973
23MP0005409_darkened_coat_color2.16997286
24MP0003329_amyloid_beta_deposits2.13009715
25MP0000749_muscle_degeneration2.12136310
26MP0000747_muscle_weakness1.98564674
27MP0004036_abnormal_muscle_relaxation1.98165760
28MP0004215_abnormal_myocardial_fiber1.97320765
29MP0009046_muscle_twitch1.96404965
30MP0005365_abnormal_bile_salt1.94679898
31MP0002272_abnormal_nervous_system1.91784270
32MP0005058_abnormal_lysosome_morphology1.86893811
33MP0002735_abnormal_chemical_nociception1.86124261
34MP0002734_abnormal_mechanical_nocicepti1.84906997
35MP0005360_urolithiasis1.83572118
36MP0000003_abnormal_adipose_tissue1.81387432
37MP0002572_abnormal_emotion/affect_behav1.76750061
38MP0002736_abnormal_nociception_after1.75628302
39MP0002909_abnormal_adrenal_gland1.69681538
40MP0001486_abnormal_startle_reflex1.69578681
41MP0004858_abnormal_nervous_system1.69373090
42MP0005423_abnormal_somatic_nervous1.68581004
43MP0005083_abnormal_biliary_tract1.68371237
44MP0000678_abnormal_parathyroid_gland1.65210343
45MP0002269_muscular_atrophy1.61239058
46MP0004084_abnormal_cardiac_muscle1.58960145
47MP0009780_abnormal_chondrocyte_physiolo1.54262944
48MP0004087_abnormal_muscle_fiber1.52171661
49MP0005330_cardiomyopathy1.51719077
50MP0002733_abnormal_thermal_nociception1.50149203
51MP0002249_abnormal_larynx_morphology1.49812553
52MP0001440_abnormal_grooming_behavior1.49422583
53MP0000566_synostosis1.45843227
54MP0001348_abnormal_lacrimal_gland1.45598107
55MP0008569_lethality_at_weaning1.44748212
56MP0005375_adipose_tissue_phenotype1.44154520
57MP0005620_abnormal_muscle_contractility1.40298395
58MP0001970_abnormal_pain_threshold1.40256788
59MP0001501_abnormal_sleep_pattern1.39023930
60MP0003137_abnormal_impulse_conducting1.38491630
61MP0003868_abnormal_feces_composition1.37938306
62MP0008875_abnormal_xenobiotic_pharmacok1.37806852
63MP0010329_abnormal_lipoprotein_level1.36963860
64MP0002106_abnormal_muscle_physiology1.35613234
65MP0004924_abnormal_behavior1.34866541
66MP0005386_behavior/neurological_phenoty1.34866541
67MP0006036_abnormal_mitochondrial_physio1.33915629
68MP0002067_abnormal_sensory_capabilities1.32567323
69MP0002971_abnormal_brown_adipose1.31202004
70MP0003806_abnormal_nucleotide_metabolis1.30622503
71MP0004233_abnormal_muscle_weight1.30121001
72MP0001502_abnormal_circadian_rhythm1.29978729
73MP0000759_abnormal_skeletal_muscle1.29341435
74MP0004811_abnormal_neuron_physiology1.27181776
75MP0000920_abnormal_myelination1.24546528
76MP0004085_abnormal_heartbeat1.23517360
77MP0009840_abnormal_foam_cell1.23346248
78MP0005535_abnormal_body_temperature1.21855486
79MP0003633_abnormal_nervous_system1.20318199
80MP0004484_altered_response_of1.18372626
81MP0000955_abnormal_spinal_cord1.17466153
82MP0005332_abnormal_amino_acid1.16009747
83MP0008961_abnormal_basal_metabolism1.15762865
84MP0006276_abnormal_autonomic_nervous1.15624958
85MP0003879_abnormal_hair_cell1.14391952
86MP0004885_abnormal_endolymph1.13679903
87MP0000604_amyloidosis1.13422815
88MP0010368_abnormal_lymphatic_system1.12737152
89MP0002108_abnormal_muscle_morphology1.12213987
90MP0002972_abnormal_cardiac_muscle1.12190903
91MP0005369_muscle_phenotype1.11601261
92MP0002066_abnormal_motor_capabilities/c1.11509928
93MP0008874_decreased_physiological_sensi1.10418785
94MP0005167_abnormal_blood-brain_barrier1.09631718
95MP0002118_abnormal_lipid_homeostasis1.09153159
96MP0002184_abnormal_innervation1.08673813
97MP0001849_ear_inflammation1.07108243
98MP0008260_abnormal_autophagy1.06755967
99MP0004142_abnormal_muscle_tone1.05474936
100MP0008438_abnormal_cutaneous_collagen1.05450075
101MP0005076_abnormal_cell_differentiation1.04591929
102MP0004510_myositis1.03042790
103MP0006035_abnormal_mitochondrial_morpho1.01601072
104MP0003634_abnormal_glial_cell0.99543531
105MP0002557_abnormal_social/conspecific_i0.99460936
106MP0005666_abnormal_adipose_tissue0.96546484
107MP0005670_abnormal_white_adipose0.96217998
108MP0000750_abnormal_muscle_regeneration0.94195006
109MP0006138_congestive_heart_failure0.93990832
110MP0008872_abnormal_physiological_respon0.93960434
111MP0005584_abnormal_enzyme/coenzyme_acti0.92231936
112MP0003631_nervous_system_phenotype0.92031566
113MP0003690_abnormal_glial_cell0.88846128
114MP0002882_abnormal_neuron_morphology0.87807440
115MP0001529_abnormal_vocalization0.87483648
116MP0001544_abnormal_cardiovascular_syste0.87359882
117MP0005385_cardiovascular_system_phenoty0.87359882
118MP0003075_altered_response_to0.86607327
119MP0000013_abnormal_adipose_tissue0.85007689
120MP0004185_abnormal_adipocyte_glucose0.83855136
121MP0010630_abnormal_cardiac_muscle0.82612347
122MP0000778_abnormal_nervous_system0.81615563
123MP0002229_neurodegeneration0.81466075
124MP0008775_abnormal_heart_ventricle0.80207888
125MP0001666_abnormal_nutrient_absorption0.79808866
126MP0003221_abnormal_cardiomyocyte_apopto0.78317688
127MP0002078_abnormal_glucose_homeostasis0.78075350
128MP0003191_abnormal_cellular_cholesterol0.77738860
129MP0005448_abnormal_energy_balance0.71160927
130MP0003045_fibrosis0.71137646
131MP0002896_abnormal_bone_mineralization0.65702178
132MP0003632_abnormal_nervous_system0.65480788
133MP0001958_emphysema0.64516636
134MP0000681_abnormal_thyroid_gland0.63266348
135MP0000609_abnormal_liver_physiology0.63250480
136MP0000733_abnormal_muscle_development0.62427885

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.18958077
2Exercise-induced myalgia (HP:0003738)4.90583059
3Focal motor seizures (HP:0011153)4.47446519
4Sudden death (HP:0001699)3.77893120
5Muscle hypertrophy of the lower extremities (HP:0008968)3.72126658
6Bundle branch block (HP:0011710)3.67040559
7Calf muscle hypertrophy (HP:0008981)3.66658528
8Exercise-induced muscle cramps (HP:0003710)3.58177487
9Myoglobinuria (HP:0002913)3.54888421
10Obstructive sleep apnea (HP:0002870)3.51062469
11Visual hallucinations (HP:0002367)3.48534416
12Focal seizures (HP:0007359)3.32514078
13Ventricular fibrillation (HP:0001663)3.31084354
14Hyporeflexia of lower limbs (HP:0002600)3.29170921
15Myotonia (HP:0002486)3.06887195
16Difficulty running (HP:0009046)3.06523027
17Complement deficiency (HP:0004431)3.01809481
18Neurofibrillary tangles (HP:0002185)2.92300203
19Joint hemorrhage (HP:0005261)2.91887770
20Muscle fiber splitting (HP:0003555)2.89806657
21Cerebral aneurysm (HP:0004944)2.89062951
22Heart block (HP:0012722)2.87462684
23Prolonged partial thromboplastin time (HP:0003645)2.83668634
24Impaired vibration sensation in the lower limbs (HP:0002166)2.83471474
25Ankle clonus (HP:0011448)2.82314701
26Protrusio acetabuli (HP:0003179)2.81578748
27Atrioventricular block (HP:0001678)2.80728546
28Myopathic facies (HP:0002058)2.78664084
29EMG: myopathic abnormalities (HP:0003458)2.77811245
30Poor eye contact (HP:0000817)2.74682032
31Ketosis (HP:0001946)2.74177893
32Abnormal social behavior (HP:0012433)2.71994507
33Impaired social interactions (HP:0000735)2.71994507
34Urinary urgency (HP:0000012)2.68927153
35Abnormality of the lower motor neuron (HP:0002366)2.67971119
36Generalized tonic-clonic seizures (HP:0002069)2.67946925
37Abnormality of the calf musculature (HP:0001430)2.67229780
38Action tremor (HP:0002345)2.66947950
39Hypercholesterolemia (HP:0003124)2.64323825
40Supranuclear gaze palsy (HP:0000605)2.62683592
41Abnormal atrioventricular conduction (HP:0005150)2.60241897
42Cerebral inclusion bodies (HP:0100314)2.58431171
43Pheochromocytoma (HP:0002666)2.55630393
44Muscle stiffness (HP:0003552)2.55196154
45Abnormality of complement system (HP:0005339)2.52700164
46Hemorrhage of the eye (HP:0011885)2.52441146
47Abnormality of the Achilles tendon (HP:0005109)2.51723080
48Muscle fiber inclusion bodies (HP:0100299)2.50000907
49Syncope (HP:0001279)2.48446609
50Ketoacidosis (HP:0001993)2.48167422
51Atonic seizures (HP:0010819)2.48127242
52Deep venous thrombosis (HP:0002625)2.47619742
53Absence seizures (HP:0002121)2.41726394
54Gout (HP:0001997)2.41573431
55Achilles tendon contracture (HP:0001771)2.41566040
56Urinary bladder sphincter dysfunction (HP:0002839)2.41181263
57Hyperlipoproteinemia (HP:0010980)2.39161468
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.38591366
59Depression (HP:0000716)2.38101002
60Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37245734
61Hyperammonemia (HP:0001987)2.37031534
62Bronchomalacia (HP:0002780)2.36591383
63Difficulty climbing stairs (HP:0003551)2.36255046
64Dysmetric saccades (HP:0000641)2.35558545
65Postural instability (HP:0002172)2.34883818
66Akinesia (HP:0002304)2.34182943
67Anxiety (HP:0000739)2.32964864
68Insidious onset (HP:0003587)2.32119467
69Termporal pattern (HP:0011008)2.32119467
70Mildly elevated creatine phosphokinase (HP:0008180)2.31470239
71Increased variability in muscle fiber diameter (HP:0003557)2.31449828
72Stridor (HP:0010307)2.30795538
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.30223673
74Hyperglycinemia (HP:0002154)2.28135650
75Ventricular arrhythmia (HP:0004308)2.26994202
76Prolonged QT interval (HP:0001657)2.25941983
77Status epilepticus (HP:0002133)2.25241635
78Hyperglycinuria (HP:0003108)2.24855484
79Round ear (HP:0100830)2.24641599
80Atrial fibrillation (HP:0005110)2.24209682
81Rhabdomyolysis (HP:0003201)2.22122288
82Mitral stenosis (HP:0001718)2.21922125
83Abnormal EKG (HP:0003115)2.20785337
84Abnormality of glycine metabolism (HP:0010895)2.18628318
85Abnormality of serine family amino acid metabolism (HP:0010894)2.18628318
86Hypercortisolism (HP:0001578)2.18473462
87Neuroendocrine neoplasm (HP:0100634)2.18018403
88Xanthomatosis (HP:0000991)2.17083783
89Dysdiadochokinesis (HP:0002075)2.16790042
90Febrile seizures (HP:0002373)2.16758783
91Primary atrial arrhythmia (HP:0001692)2.16728980
92Dialeptic seizures (HP:0011146)2.15813650
93Dysmetria (HP:0001310)2.15059754
94Epileptic encephalopathy (HP:0200134)2.15030513
95Distal upper limb amyotrophy (HP:0007149)2.13725822
96Upper limb amyotrophy (HP:0009129)2.13725822
97Spastic gait (HP:0002064)2.11958160
98Torticollis (HP:0000473)2.11622910
99Foot dorsiflexor weakness (HP:0009027)2.10835915
100Spinal rigidity (HP:0003306)2.08676377
101Abnormality of binocular vision (HP:0011514)2.08575989
102Diplopia (HP:0000651)2.08575989
103Hypobetalipoproteinemia (HP:0003563)2.07426448
104Supraventricular tachycardia (HP:0004755)2.06913596
105Ventricular tachycardia (HP:0004756)2.05302690
106Abnormality of skeletal muscle fiber size (HP:0012084)2.04907161
107Nemaline bodies (HP:0003798)2.02413703
108Asymmetric septal hypertrophy (HP:0001670)2.02384233
109Distal arthrogryposis (HP:0005684)2.01056818
110Focal dystonia (HP:0004373)2.00166887
111Supraventricular arrhythmia (HP:0005115)2.00060816
112Scanning speech (HP:0002168)1.99133712
113EMG: neuropathic changes (HP:0003445)1.96277196
114Impaired vibratory sensation (HP:0002495)1.96155348
115Rapidly progressive (HP:0003678)1.95107005
116Abnormality of the foot musculature (HP:0001436)1.94454894
117Areflexia of lower limbs (HP:0002522)1.94294090
118Hypoalphalipoproteinemia (HP:0003233)1.93838161
119Limb-girdle muscle atrophy (HP:0003797)1.93641644
120Progressive cerebellar ataxia (HP:0002073)1.93633342
121Distal lower limb amyotrophy (HP:0008944)1.93380149
122Cholelithiasis (HP:0001081)1.92754136
123Palpitations (HP:0001962)1.91641166
124Craniofacial dystonia (HP:0012179)1.90176226
125Reticulocytosis (HP:0001923)1.90152845
126Annular pancreas (HP:0001734)1.89481431
127Truncal ataxia (HP:0002078)1.88652202
128Bulbar palsy (HP:0001283)1.88648623
129Subaortic stenosis (HP:0001682)1.88524871
130Abnormality of the left ventricular outflow tract (HP:0011103)1.88524871
131Hyperacusis (HP:0010780)1.88449722
132Athetosis (HP:0002305)1.87888168
133Neonatal onset (HP:0003623)1.87861550
134Glomerulonephritis (HP:0000099)1.87774514
135Type 1 muscle fiber predominance (HP:0003803)1.87064175
136Increased connective tissue (HP:0009025)1.85935086
137Rigidity (HP:0002063)1.84035514
138Ulnar deviation of the wrist (HP:0003049)1.83315441
139Abnormality of monocarboxylic acid metabolism (HP:0010996)1.82308317
140Insomnia (HP:0100785)1.81295628
141Lower limb amyotrophy (HP:0007210)1.80894140
142Growth hormone excess (HP:0000845)1.77881180
143Skin nodule (HP:0200036)1.77730240
144Thin bony cortex (HP:0002753)1.76540666
145Shallow orbits (HP:0000586)1.76525737
146Distal lower limb muscle weakness (HP:0009053)1.76170475
147Systemic lupus erythematosus (HP:0002725)1.75796286
148Neuronal loss in central nervous system (HP:0002529)1.73414659
149Flat acetabular roof (HP:0003180)1.71015046
150Small epiphyses (HP:0010585)1.68495980
151Spinal canal stenosis (HP:0003416)1.68161896
152Abnormality of carpal bone ossification (HP:0006257)1.67755713
153Impaired pain sensation (HP:0007328)1.67371409
154Abnormality of pain sensation (HP:0010832)1.67371409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA43.76062095
2MAP3K93.44227482
3NTRK33.42543814
4PHKG22.87625984
5PHKG12.87625984
6FGFR42.72154011
7ICK2.68906037
8KSR22.52528315
9EEF2K2.43895115
10MAP2K42.41236098
11DAPK22.39478885
12SIK12.36606091
13MAP3K42.34306933
14TRIB32.26483910
15MINK12.25129236
16BCKDK2.18365318
17PAK62.16529991
18PRKD32.09563346
19MARK12.06417428
20PINK12.02663711
21LMTK21.99499280
22NTRK11.87692340
23TTN1.82621731
24CAMKK11.80949218
25STK381.69109057
26MUSK1.57106616
27OBSCN1.55389550
28FGFR31.55119240
29NEK11.54966576
30MAP2K71.52754252
31ERN11.51511427
32CDK121.45263319
33PDK41.41394084
34PDK31.41394084
35SMG11.39376743
36PDGFRA1.36356048
37LATS21.30372713
38PKN21.28227173
39TAOK11.27104042
40NTRK21.23619826
41MAP3K71.23224934
42CDK51.18591867
43KSR11.11950133
44ARAF1.07278892
45NME11.07196296
46WNK11.04875481
47RET1.04317737
48DAPK11.01227270
49PRKCG0.99540583
50PDPK10.98371253
51CDK190.97869338
52GRK50.97201648
53MAP3K20.97110987
54MAPK120.96560783
55MAPK110.94930761
56TYRO30.92475156
57TNIK0.90633675
58SIK20.89944547
59MAP3K130.89769911
60PDK10.89255946
61CAMK10.87467432
62MAP3K120.86247030
63PRKCH0.85093922
64STK110.85068757
65DDR20.84368317
66MTOR0.83487616
67MAP3K10.80662310
68PAK30.80546225
69PRPF4B0.76433282
70PRKD20.75729779
71CAMK2A0.75432906
72MAP3K60.75025495
73CAMKK20.73517388
74FES0.73173295
75ALK0.72814313
76RIPK10.72309111
77PTK20.71492402
78MAP2K30.71471499
79TAOK20.71433157
80DMPK0.70255963
81MAP2K60.69647685
82RIPK40.68753331
83SGK2230.68410006
84SGK4940.68410006
85UHMK10.67457663
86PDK20.67042599
87CAMK2G0.66047952
88DYRK1B0.64024501
89SGK30.63750701
90PRKAA20.62495243
91TNK20.62461755
92CAMK40.61933711
93EPHA20.61268719
94MAPK130.60986258
95MAP2K10.60393105
96BMX0.59851065
97RAF10.57604053
98NEK60.57469974
99MAPK100.57414453
100PTK60.56748643
101PRKAA10.55939176
102MARK20.54374026
103CDK150.54289921
104FGFR20.51786633
105RPS6KA30.51710726
106RPS6KB10.51538912
107CDK180.50972934
108DAPK30.50576652
109PRKCZ0.50198426
110CAMK2D0.50052878
111CDK140.49747339
112PRKD10.49654972
113SGK10.48664127
114PRKG20.48207718
115CDK11A0.45150505
116MAP3K110.44773284
117PDGFRB0.44352634
118PTK2B0.43819290
119CDC42BPA0.41540715
120SGK20.40702412
121CAMK2B0.40644622
122HIPK20.40592571
123PRKACB0.38992740
124PRKACG0.38975961
125CAMK1G0.38574740
126IRAK30.38554140
127MAPKAPK30.37966824
128RPS6KA20.36871159
129PIK3CA0.36539843
130PNCK0.36204418
131CSNK1G20.35587560
132MAPK80.35140962
133MAPK150.34882490

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37278488
2Nitrogen metabolism_Homo sapiens_hsa009103.13198271
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40298464
4Arginine biosynthesis_Homo sapiens_hsa002202.36469837
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.16326992
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.10851721
7Synaptic vesicle cycle_Homo sapiens_hsa047211.90718690
8Propanoate metabolism_Homo sapiens_hsa006401.78556342
9Olfactory transduction_Homo sapiens_hsa047401.76984491
10Nicotine addiction_Homo sapiens_hsa050331.74911386
11Fatty acid degradation_Homo sapiens_hsa000711.71725752
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71622537
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.71398037
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.67284989
15Circadian entrainment_Homo sapiens_hsa047131.66808498
16Butanoate metabolism_Homo sapiens_hsa006501.64900331
17GABAergic synapse_Homo sapiens_hsa047271.63056623
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.62831241
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62675780
20Long-term potentiation_Homo sapiens_hsa047201.62623268
21Cardiac muscle contraction_Homo sapiens_hsa042601.56366863
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55968858
23Glutamatergic synapse_Homo sapiens_hsa047241.50726965
24Prion diseases_Homo sapiens_hsa050201.48782973
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46946931
26Fatty acid metabolism_Homo sapiens_hsa012121.40556472
27Insulin secretion_Homo sapiens_hsa049111.38904748
28Other glycan degradation_Homo sapiens_hsa005111.38772824
29Salivary secretion_Homo sapiens_hsa049701.36614556
30Amphetamine addiction_Homo sapiens_hsa050311.35877589
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33508545
32Gastric acid secretion_Homo sapiens_hsa049711.32271332
33Morphine addiction_Homo sapiens_hsa050321.30340561
34Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30247538
35Histidine metabolism_Homo sapiens_hsa003401.27861741
36Bile secretion_Homo sapiens_hsa049761.25142081
37Dopaminergic synapse_Homo sapiens_hsa047281.24845966
38Carbon metabolism_Homo sapiens_hsa012001.23240118
39Oxytocin signaling pathway_Homo sapiens_hsa049211.20303902
40Calcium signaling pathway_Homo sapiens_hsa040201.17954464
41Cholinergic synapse_Homo sapiens_hsa047251.17445181
42Fructose and mannose metabolism_Homo sapiens_hsa000511.14679171
43Pyruvate metabolism_Homo sapiens_hsa006201.14551554
44PPAR signaling pathway_Homo sapiens_hsa033201.12938393
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08575323
46Dilated cardiomyopathy_Homo sapiens_hsa054141.07713638
47Biosynthesis of amino acids_Homo sapiens_hsa012301.07475042
48ABC transporters_Homo sapiens_hsa020101.05088287
49Tryptophan metabolism_Homo sapiens_hsa003801.04270217
50Renin secretion_Homo sapiens_hsa049241.02420831
51Glucagon signaling pathway_Homo sapiens_hsa049221.00137891
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99473823
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99146256
54GnRH signaling pathway_Homo sapiens_hsa049120.98706183
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.94928776
56mTOR signaling pathway_Homo sapiens_hsa041500.94746326
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92685115
58Thyroid hormone synthesis_Homo sapiens_hsa049180.92005958
59Type II diabetes mellitus_Homo sapiens_hsa049300.89324955
60Tyrosine metabolism_Homo sapiens_hsa003500.88979905
61Insulin signaling pathway_Homo sapiens_hsa049100.85507514
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85071846
63Taste transduction_Homo sapiens_hsa047420.80881080
64Long-term depression_Homo sapiens_hsa047300.79430710
65Gap junction_Homo sapiens_hsa045400.79405325
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.79216479
67Glycosaminoglycan degradation_Homo sapiens_hsa005310.77939427
68Circadian rhythm_Homo sapiens_hsa047100.76910284
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.76702264
70beta-Alanine metabolism_Homo sapiens_hsa004100.76676368
71Choline metabolism in cancer_Homo sapiens_hsa052310.76497153
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75639746
73Vitamin B6 metabolism_Homo sapiens_hsa007500.75331893
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75057796
75Cocaine addiction_Homo sapiens_hsa050300.75014451
76cAMP signaling pathway_Homo sapiens_hsa040240.73627868
77Inositol phosphate metabolism_Homo sapiens_hsa005620.73236248
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73178877
79Neurotrophin signaling pathway_Homo sapiens_hsa047220.72870487
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72302576
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.71612538
82Pancreatic secretion_Homo sapiens_hsa049720.70586719
83Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69792145
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.68868003
85Fatty acid biosynthesis_Homo sapiens_hsa000610.68486179
86Starch and sucrose metabolism_Homo sapiens_hsa005000.67730305
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.66718148
88Peroxisome_Homo sapiens_hsa041460.65733067
89Glycerolipid metabolism_Homo sapiens_hsa005610.65619786
90Parkinsons disease_Homo sapiens_hsa050120.64700967
91Estrogen signaling pathway_Homo sapiens_hsa049150.64322201
92Glioma_Homo sapiens_hsa052140.63584705
93Insulin resistance_Homo sapiens_hsa049310.63357295
94Alzheimers disease_Homo sapiens_hsa050100.62932466
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62438492
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.61727730
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61551950
98Non-small cell lung cancer_Homo sapiens_hsa052230.60506504
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59173462
100Endometrial cancer_Homo sapiens_hsa052130.59039464
101Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58343555
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.58291837
103Focal adhesion_Homo sapiens_hsa045100.57566080
104AMPK signaling pathway_Homo sapiens_hsa041520.57479622
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56704250
106Fatty acid elongation_Homo sapiens_hsa000620.55785362
107Dorso-ventral axis formation_Homo sapiens_hsa043200.55719815
108Lysine degradation_Homo sapiens_hsa003100.55672470
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55669020
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55395502
111MAPK signaling pathway_Homo sapiens_hsa040100.54812488
112Serotonergic synapse_Homo sapiens_hsa047260.54479154
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.54144921
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.53933123
115Phenylalanine metabolism_Homo sapiens_hsa003600.53286670
116Complement and coagulation cascades_Homo sapiens_hsa046100.52935429
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52135681
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51297867
119ErbB signaling pathway_Homo sapiens_hsa040120.50859984
120Ovarian steroidogenesis_Homo sapiens_hsa049130.48922870
121Fat digestion and absorption_Homo sapiens_hsa049750.48920217
122VEGF signaling pathway_Homo sapiens_hsa043700.48364713
123Melanogenesis_Homo sapiens_hsa049160.47994289
124Arginine and proline metabolism_Homo sapiens_hsa003300.47953990
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46895214
126Sulfur relay system_Homo sapiens_hsa041220.46057709
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.45943396

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