ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	muscle filament sliding (GO:0030049)	7.82307753
2	actin-myosin filament sliding (GO:0033275)	7.82307753
3	regulation of skeletal muscle contraction (GO:0014819)	7.44316656
4	actin-mediated cell contraction (GO:0070252)	6.82278268
5	sarcomere organization (GO:0045214)	6.58668049
6	sarcoplasmic reticulum calcium ion transport (GO:0070296)	5.85697314
7	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	5.80846857
8	myofibril assembly (GO:0030239)	5.78231576
9	actin filament-based movement (GO:0030048)	5.21633738
10	skeletal muscle contraction (GO:0003009)	5.16263890
11	cardiac myofibril assembly (GO:0055003)	5.15509704
12	regulation of relaxation of muscle (GO:1901077)	5.09836439
13	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	4.93580563
14	skeletal muscle adaptation (GO:0043501)	4.92297708
15	regulation of cell communication by electrical coupling (GO:0010649)	4.84272951
16	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	4.81733318
17	creatine metabolic process (GO:0006600)	4.77815403
18	actomyosin structure organization (GO:0031032)	4.67506836
19	regulation of actin filament-based movement (GO:1903115)	4.66961827
20	striated muscle contraction (GO:0006941)	4.62527843
21	* response to stimulus involved in regulation of muscle adaptation (GO:0014874)	4.54719405
22	cardiac muscle contraction (GO:0060048)	4.40396274
23	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	4.38126552
24	negative regulation of protein localization to cell surface (GO:2000009)	4.32728643
25	bundle of His cell to Purkinje myocyte communication (GO:0086069)	4.25216092
26	plasma membrane repair (GO:0001778)	4.24754036
27	myotube cell development (GO:0014904)	4.21796842
28	cardiac muscle tissue morphogenesis (GO:0055008)	4.10565729
29	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.05622489
30	muscle tissue morphogenesis (GO:0060415)	3.96161460
31	regulation of striated muscle contraction (GO:0006942)	3.85234984
32	striated muscle atrophy (GO:0014891)	3.83668371
33	skeletal muscle tissue development (GO:0007519)	3.83033164
34	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	3.78403652
35	cardiac muscle cell development (GO:0055013)	3.77809323
36	central nervous system myelination (GO:0022010)	3.74727917
37	axon ensheathment in central nervous system (GO:0032291)	3.74727917
38	muscle contraction (GO:0006936)	3.70590985
39	heart process (GO:0003015)	3.69103244
40	heart contraction (GO:0060047)	3.69103244
41	cardiac cell development (GO:0055006)	3.68113333
42	desmosome organization (GO:0002934)	3.63369585
43	carnitine shuttle (GO:0006853)	3.63217680
44	adult heart development (GO:0007512)	3.58986063
45	cardiac muscle hypertrophy (GO:0003300)	3.56737304
46	striated muscle hypertrophy (GO:0014897)	3.48978657
47	muscle atrophy (GO:0014889)	3.46035017
48	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.45979789
49	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.42840202
50	muscle hypertrophy in response to stress (GO:0003299)	3.42840202
51	cardiac muscle adaptation (GO:0014887)	3.42840202
52	ventricular cardiac muscle tissue morphogenesis (GO:0055010)	3.40823724
53	muscle system process (GO:0003012)	3.39801599
54	regulation of sarcomere organization (GO:0060297)	3.39555469
55	ventricular cardiac muscle cell action potential (GO:0086005)	3.39305881
56	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.32241976
57	striated muscle adaptation (GO:0014888)	3.31091019
58	muscle organ development (GO:0007517)	3.28712895
59	response to muscle activity (GO:0014850)	3.26808965
60	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	3.26784236
61	myoblast fusion (GO:0007520)	3.24149496
62	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.23324652
63	hemidesmosome assembly (GO:0031581)	3.22262106
64	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	3.18674911
65	glycogen biosynthetic process (GO:0005978)	3.17804772
66	glucan biosynthetic process (GO:0009250)	3.17804772
67	regulation of cardioblast differentiation (GO:0051890)	3.13841035
68	macroautophagy (GO:0016236)	3.12178343
69	eye photoreceptor cell differentiation (GO:0001754)	3.10624784
70	photoreceptor cell differentiation (GO:0046530)	3.10624784
71	glycogen catabolic process (GO:0005980)	3.08184457
72	regulation of skeletal muscle cell differentiation (GO:2001014)	3.05692619
73	regulation of cardiac muscle cell contraction (GO:0086004)	3.05523855
74	regulation of cardioblast proliferation (GO:0003264)	3.04994635
75	regulation of secondary heart field cardioblast proliferation (GO:0003266)	3.04994635
76	myotube differentiation (GO:0014902)	3.04701886
77	heart trabecula formation (GO:0060347)	3.03847830
78	negative regulation of skeletal muscle tissue development (GO:0048642)	3.03532393
79	* response to inactivity (GO:0014854)	3.02071476
80	positive regulation of myoblast differentiation (GO:0045663)	2.99995306
81	muscle hypertrophy (GO:0014896)	2.98901175
82	muscle fiber development (GO:0048747)	2.98662994
83	muscle cell development (GO:0055001)	2.97876416
84	cell communication by electrical coupling involved in cardiac conduction (GO:0086064)	2.97023841
85	striated muscle tissue development (GO:0014706)	2.96042878
86	skeletal muscle tissue regeneration (GO:0043403)	2.93212666
87	muscle cell fate commitment (GO:0042693)	2.92989920
88	regulation of acyl-CoA biosynthetic process (GO:0050812)	2.92320555
89	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.92229256
90	skeletal muscle fiber development (GO:0048741)	2.91023239
91	fatty acid transmembrane transport (GO:1902001)	2.91004967
92	syncytium formation by plasma membrane fusion (GO:0000768)	2.89904665
93	regulation of myoblast differentiation (GO:0045661)	2.87961129
94	regulation of calcium ion transmembrane transport (GO:1903169)	2.87084833
95	regulation of calcium ion transmembrane transporter activity (GO:1901019)	2.87084833
96	regulation of muscle contraction (GO:0006937)	2.87005104
97	glucan catabolic process (GO:0009251)	2.85462773
98	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.84897734
99	muscle tissue development (GO:0060537)	2.84707949
100	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	2.81697846
101	regulation of cardiac muscle contraction (GO:0055117)	2.81516232
102	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.77022757
103	muscle cell cellular homeostasis (GO:0046716)	2.76054665
104	positive regulation of cation channel activity (GO:2001259)	2.75890050
105	striated muscle cell development (GO:0055002)	2.74899231
106	ensheathment of neurons (GO:0007272)	2.74895878
107	axon ensheathment (GO:0008366)	2.74895878
108	regulation of membrane repolarization (GO:0060306)	2.74623634
109	relaxation of cardiac muscle (GO:0055119)	2.74253518
110	myelination (GO:0042552)	2.73912495
111	regulation of the force of heart contraction (GO:0002026)	2.73599809
112	regulation of somitogenesis (GO:0014807)	2.71918168
113	fibroblast migration (GO:0010761)	2.69832906
114	muscle adaptation (GO:0043500)	2.68860447
115	carnitine transmembrane transport (GO:1902603)	2.68743380
116	NADH metabolic process (GO:0006734)	2.67407213
117	cellular polysaccharide catabolic process (GO:0044247)	2.65143501
118	cellular response to epinephrine stimulus (GO:0071872)	2.61902443
119	regulation of muscle system process (GO:0090257)	2.61286131
120	muscle structure development (GO:0061061)	2.60819252
121	relaxation of muscle (GO:0090075)	2.59953326
122	response to epinephrine (GO:0071871)	2.59767371
123	cardiac muscle cell action potential (GO:0086001)	2.57020797
124	positive regulation of heart rate (GO:0010460)	2.55925362
125	respiratory electron transport chain (GO:0022904)	2.55804357
126	cell communication involved in cardiac conduction (GO:0086065)	2.55660577
127	negative regulation of calcium ion transmembrane transport (GO:1903170)	2.55570118

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EP300_21415370_ChIP-Seq_HL-1_Mouse	2.87960884
2	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.73816724
3	TP63_17297297_ChIP-ChIP_HaCaT_Human	2.72286942
4	* CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.48226002
5	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.30620512
6	* SMAD_19615063_ChIP-ChIP_OVARY_Human	2.10855924
7	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.06515613
8	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.95486315
9	EZH2_22144423_ChIP-Seq_EOC_Human	1.91343755
10	* TBX20_22328084_ChIP-Seq_HEART_Mouse	1.81998412
11	* TBX20_22080862_ChIP-Seq_HEART_Mouse	1.81998412
12	* SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.79751178
13	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.76917541
14	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.76272583
15	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.75085638
16	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.66585222
17	* EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.66579783
18	* RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.66579783
19	* ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.66447931
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64227399
21	* SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.62968569
22	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.62838850
23	* SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.56973035
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.54749222
25	WT1_19549856_ChIP-ChIP_CCG9911_Human	1.54204607
26	* ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.52631790
27	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.52315470
28	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50878614
29	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.50623522
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49594567
31	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.48543257
32	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.48540161
33	AHR_22903824_ChIP-Seq_MCF-7_Human	1.48468352
34	CLOCK_20551151_ChIP-Seq_293T_Human	1.46652553
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.45935138
36	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45245576
37	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.44318589
38	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.44318589
39	* MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.42850648
40	* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41978515
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.40471348
42	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.39156332
43	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.38908101
44	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.38380224
45	DROSHA_22980978_ChIP-Seq_HELA_Human	1.36910128
46	SOX9_24532713_ChIP-Seq_HFSC_Mouse	1.36342147
47	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.35845493
48	* SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.35114050
49	* CJUN_26792858_Chip-Seq_BT549_Human	1.34968743
50	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.34242115
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30686369
52	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	1.30382066
53	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.30243961
54	VDR_22108803_ChIP-Seq_LS180_Human	1.29280674
55	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.27988162
56	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.27812477
57	* SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.27665770
58	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.25885304
59	* TP53_16413492_ChIP-PET_HCT116_Human	1.25204340
60	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.24582749
61	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.24135229
62	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.23377384
63	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.23171489
64	* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	1.22896002
65	* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse	1.21844787
66	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	1.21806548
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.20987972
68	TP53_18474530_ChIP-ChIP_U2OS_Human	1.20979740
69	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.20683895
70	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.19355309
71	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.19264015
72	ER_23166858_ChIP-Seq_MCF-7_Human	1.17529482
73	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.17101836
74	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16758684
75	* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	1.15686639
76	* SMAD3_18955504_ChIP-ChIP_HaCaT_Human	1.15053377
77	* SMAD2_18955504_ChIP-ChIP_HaCaT_Human	1.15053377
78	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.13731455
79	* BRD4_25478319_ChIP-Seq_HGPS_Human	1.13215963
80	* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	1.12740640
81	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.10734101
82	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	1.09900806
83	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.09232381
84	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.07885603
85	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.06982320
86	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.05801125
87	P63_26484246_Chip-Seq_KERATINOCYTES_Human	1.04911006
88	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.03767068
89	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.02413380
90	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.01678569
91	* FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.01210359
92	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.01200456
93	WT1_25993318_ChIP-Seq_PODOCYTE_Human	1.01053917
94	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.00727698
95	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.00568534
96	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.99889412
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99690263
98	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.99623499
99	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.98371995
100	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.98161457
101	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	0.97953239
102	HIF1A_21447827_ChIP-Seq_MCF-7_Human	0.97904909
103	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97874139
104	GATA2_21666600_ChIP-Seq_HMVEC_Human	0.97608510
105	* SOX2_20726797_ChIP-Seq_SW620_Human	0.96998269
106	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.95517990
107	BCAT_22108803_ChIP-Seq_LS180_Human	0.95366864
108	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.95359466
109	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.95065434
110	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.94341192
111	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.93830902
112	TAF15_26573619_Chip-Seq_HEK293_Human	0.93744539
113	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.93408924
114	* CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.92567472
115	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.92422984
116	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.91586582
117	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.90922992
118	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.89143428
119	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.87832756
120	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87824526
121	FOXA2_19822575_ChIP-Seq_HepG2_Human	0.87699130
122	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.87680020
123	* TP63_23658742_ChIP-Seq_EP156T_Human	0.87564886
124	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.86537776
125	* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse	0.85463420
126	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.85114299
127	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.84732694
128	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.83288281
129	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.83082919
130	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.83056680
131	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.82816775
132	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.82368469
133	ZNF274_21170338_ChIP-Seq_K562_Hela	0.81976496
134	SMAD4_21799915_ChIP-Seq_A2780_Human	0.81828877
135	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.81637365
136	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.81514896

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000749_muscle_degeneration	4.77912031
2	MP0004145_abnormal_muscle_electrophysio	4.71555827
3	MP0000751_myopathy	4.60969764
4	MP0002837_dystrophic_cardiac_calcinosis	4.26230638
5	MP0003646_muscle_fatigue	4.04807843
6	MP0004036_abnormal_muscle_relaxation	3.92997769
7	MP0004084_abnormal_cardiac_muscle	3.56659905
8	MP0004087_abnormal_muscle_fiber	2.96379093
9	* MP0002106_abnormal_muscle_physiology	2.85129389
10	MP0005330_cardiomyopathy	2.84809398
11	MP0005620_abnormal_muscle_contractility	2.76535442
12	MP0004215_abnormal_myocardial_fiber	2.75916327
13	MP0000747_muscle_weakness	2.65283805
14	MP0000759_abnormal_skeletal_muscle	2.51031134
15	* MP0005369_muscle_phenotype	2.45875374
16	MP0000750_abnormal_muscle_regeneration	2.45709336
17	MP0002972_abnormal_cardiac_muscle	2.37807776
18	MP0004130_abnormal_muscle_cell	2.36327089
19	MP0003950_abnormal_plasma_membrane	2.26951625
20	* MP0002269_muscular_atrophy	2.01956754
21	MP0001485_abnormal_pinna_reflex	2.01194278
22	MP0003137_abnormal_impulse_conducting	1.93087407
23	MP0004484_altered_response_of	1.89561826
24	MP0010630_abnormal_cardiac_muscle	1.81580895
25	MP0005377_hearing/vestibular/ear_phenot	1.72734192
26	MP0003878_abnormal_ear_physiology	1.72734192
27	MP0008775_abnormal_heart_ventricle	1.69706969
28	MP0005670_abnormal_white_adipose	1.67457453
29	MP0009780_abnormal_chondrocyte_physiolo	1.62201108
30	MP0000762_abnormal_tongue_morphology	1.60482110
31	MP0002108_abnormal_muscle_morphology	1.58153760
32	MP0005385_cardiovascular_system_phenoty	1.57671859
33	MP0001544_abnormal_cardiovascular_syste	1.57671859
34	MP0000733_abnormal_muscle_development	1.50536831
35	MP0003828_pulmonary_edema	1.44463765
36	MP0004085_abnormal_heartbeat	1.40704690
37	MP0000920_abnormal_myelination	1.37272101
38	MP0006138_congestive_heart_failure	1.35842136
39	MP0004510_myositis	1.34429643
40	MP0002332_abnormal_exercise_endurance	1.31502056
41	MP0001661_extended_life_span	1.29476313
42	MP0003705_abnormal_hypodermis_morpholog	1.27860349
43	MP0002009_preneoplasia	1.24781839
44	MP0004185_abnormal_adipocyte_glucose	1.20102463
45	MP0000383_abnormal_hair_follicle	1.16468790
46	MP0001958_emphysema	1.15758895
47	MP0003221_abnormal_cardiomyocyte_apopto	1.14433390
48	MP0004233_abnormal_muscle_weight	1.13167866
49	MP0005275_abnormal_skin_tensile	1.12055970
50	MP0010678_abnormal_skin_adnexa	1.11819364
51	MP0009250_abnormal_appendicular_skeleto	1.11074166
52	MP0002234_abnormal_pharynx_morphology	1.10305262
53	MP0004134_abnormal_chest_morphology	1.05120688
54	MP0005666_abnormal_adipose_tissue	1.03941023
55	MP0001346_abnormal_lacrimal_gland	1.02911255
56	MP0005171_absent_coat_pigmentation	1.01728202
57	MP0008789_abnormal_olfactory_epithelium	1.01719601
58	MP0004272_abnormal_basement_membrane	1.01403944
59	MP0004381_abnormal_hair_follicle	0.99215306
60	MP0000579_abnormal_nail_morphology	0.97129466
61	MP0003941_abnormal_skin_development	0.96735706
62	MP0002896_abnormal_bone_mineralization	0.93807825
63	MP0005375_adipose_tissue_phenotype	0.93800692
64	MP0006036_abnormal_mitochondrial_physio	0.90772265
65	MP0001299_abnormal_eye_distance/	0.90539200
66	MP0003091_abnormal_cell_migration	0.89020688
67	MP0003566_abnormal_cell_adhesion	0.88937885
68	MP0002127_abnormal_cardiovascular_syste	0.87646483
69	MP0001879_abnormal_lymphatic_vessel	0.87096298
70	MP0000467_abnormal_esophagus_morphology	0.85970141
71	MP0005451_abnormal_body_composition	0.84662826
72	MP0008438_abnormal_cutaneous_collagen	0.84297059
73	MP0004147_increased_porphyrin_level	0.83639170
74	MP0002971_abnormal_brown_adipose	0.83237649
75	MP0010368_abnormal_lymphatic_system	0.82847416
76	MP0005023_abnormal_wound_healing	0.81496902
77	MP0002254_reproductive_system_inflammat	0.79734809
78	MP0009384_cardiac_valve_regurgitation	0.79568344
79	MP0004742_abnormal_vestibular_system	0.79560945
80	MP0004270_analgesia	0.77789713
81	MP0002168_other_aberrant_phenotype	0.77671971
82	MP0005499_abnormal_olfactory_system	0.76905179
83	MP0005394_taste/olfaction_phenotype	0.76905179
84	MP0002877_abnormal_melanocyte_morpholog	0.76362458
85	MP0003879_abnormal_hair_cell	0.75877942
86	MP0000566_synostosis	0.75215691
87	MP0000003_abnormal_adipose_tissue	0.73333668
88	MP0005266_abnormal_metabolism	0.72184251
89	MP0003136_yellow_coat_color	0.71945729
90	MP0002128_abnormal_blood_circulation	0.71045673
91	MP0005595_abnormal_vascular_smooth	0.70292902
92	MP0000026_abnormal_inner_ear	0.69194669
93	MP0002796_impaired_skin_barrier	0.68810916
94	MP0005623_abnormal_meninges_morphology	0.68749025
95	MP0010030_abnormal_orbit_morphology	0.68591209
96	MP0001849_ear_inflammation	0.67654102
97	MP0005165_increased_susceptibility_to	0.65595639
98	MP0004043_abnormal_pH_regulation	0.65545796
99	MP0000230_abnormal_systemic_arterial	0.64695451
100	MP0002098_abnormal_vibrissa_morphology	0.64626483
101	MP0000266_abnormal_heart_morphology	0.62899248
102	MP0003045_fibrosis	0.61867431
103	MP0000013_abnormal_adipose_tissue	0.61171767
104	MP0000049_abnormal_middle_ear	0.60288072
105	MP0004885_abnormal_endolymph	0.60032003
106	MP0000372_irregular_coat_pigmentation	0.59339457
107	MP0001963_abnormal_hearing_physiology	0.58547914
108	MP0001486_abnormal_startle_reflex	0.58536645
109	MP0003385_abnormal_body_wall	0.58188301
110	MP0005409_darkened_coat_color	0.58125218
111	MP0005503_abnormal_tendon_morphology	0.58115631
112	MP0000647_abnormal_sebaceous_gland	0.57305862
113	MP0002060_abnormal_skin_morphology	0.57224043
114	MP0002233_abnormal_nose_morphology	0.56834335
115	MP0003567_abnormal_fetal_cardiomyocyte	0.56652248
116	MP0000767_abnormal_smooth_muscle	0.56574482
117	MP0003279_aneurysm	0.56431428
118	MP0000462_abnormal_digestive_system	0.56412880
119	MP0000343_altered_response_to	0.55457530
120	MP0002933_joint_inflammation	0.55151670
121	MP0005508_abnormal_skeleton_morphology	0.54568540
122	MP0001502_abnormal_circadian_rhythm	0.45608525
123	MP0000534_abnormal_ureter_morphology	0.43240952
124	MP0003011_delayed_dark_adaptation	0.42699052
125	MP0002295_abnormal_pulmonary_circulatio	0.42577794
126	MP0002114_abnormal_axial_skeleton	0.41898888
127	MP0005164_abnormal_response_to	0.38762832
128	MP0008569_lethality_at_weaning	0.38136903
129	MP0002998_abnormal_bone_remodeling	0.36944656
130	MP0005166_decreased_susceptibility_to	0.35557063
131	MP0001614_abnormal_blood_vessel	0.34556683
132	MP0005257_abnormal_intraocular_pressure	0.33664990

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Muscle hypertrophy of the lower extremities (HP:0008968)	7.04027272
2	Muscle fiber inclusion bodies (HP:0100299)	6.92850773
3	Calf muscle hypertrophy (HP:0008981)	6.90162612
4	Exercise-induced myalgia (HP:0003738)	6.86530757
5	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	6.80498569
6	Nemaline bodies (HP:0003798)	6.29080761
7	Exercise-induced muscle cramps (HP:0003710)	6.22730391
8	Muscle fiber splitting (HP:0003555)	5.80681516
9	Hyporeflexia of lower limbs (HP:0002600)	5.66589315
10	Type 1 muscle fiber predominance (HP:0003803)	5.21631562
11	Sudden death (HP:0001699)	5.14609393
12	Abnormality of the calf musculature (HP:0001430)	5.12066047
13	Ventricular tachycardia (HP:0004756)	4.76898794
14	EMG: myopathic abnormalities (HP:0003458)	4.54494437
15	Difficulty running (HP:0009046)	4.44048906
16	Right ventricular cardiomyopathy (HP:0011663)	4.28937599
17	Distal arthrogryposis (HP:0005684)	4.14330991
18	Myoglobinuria (HP:0002913)	4.13726597
19	Round ear (HP:0100830)	3.95161009
20	Subaortic stenosis (HP:0001682)	3.85123788
21	Abnormality of the left ventricular outflow tract (HP:0011103)	3.85123788
22	Myopathic facies (HP:0002058)	3.78948693
23	Atrial fibrillation (HP:0005110)	3.68765762
24	Increased connective tissue (HP:0009025)	3.55272730
25	Lipoatrophy (HP:0100578)	3.46990678
26	Neck muscle weakness (HP:0000467)	3.46318759
27	Primary atrial arrhythmia (HP:0001692)	3.37730055
28	Aortic aneurysm (HP:0004942)	3.35928920
29	Muscle stiffness (HP:0003552)	3.28994576
30	Dilated cardiomyopathy (HP:0001644)	3.24871872
31	Supraventricular tachycardia (HP:0004755)	3.22828987
32	Supraventricular arrhythmia (HP:0005115)	3.14305800
33	Myotonia (HP:0002486)	3.13487613
34	Distal lower limb muscle weakness (HP:0009053)	3.03303691
35	Rhabdomyolysis (HP:0003201)	3.00320776
36	Ulnar deviation of the wrist (HP:0003049)	2.87071432
37	Syncope (HP:0001279)	2.83839206
38	Abnormality of skeletal muscle fiber size (HP:0012084)	2.83554718
39	Absent phalangeal crease (HP:0006109)	2.83202995
40	Hypoplastic ischia (HP:0003175)	2.81251076
41	Rimmed vacuoles (HP:0003805)	2.79319689
42	Slender build (HP:0001533)	2.79236712
43	Prolonged QT interval (HP:0001657)	2.77926172
44	Scapular winging (HP:0003691)	2.77804874
45	Increased variability in muscle fiber diameter (HP:0003557)	2.73393781
46	Gowers sign (HP:0003391)	2.64636303
47	Areflexia of lower limbs (HP:0002522)	2.63904307
48	Calcaneovalgus deformity (HP:0001848)	2.60021755
49	Asymmetric septal hypertrophy (HP:0001670)	2.57619076
50	Ventricular arrhythmia (HP:0004308)	2.56614153
51	Abnormality of the ischium (HP:0003174)	2.54480488
52	Difficulty climbing stairs (HP:0003551)	2.52731024
53	Fatigable weakness (HP:0003473)	2.47981667
54	Abnormality of the neuromuscular junction (HP:0003398)	2.47981667
55	Popliteal pterygium (HP:0009756)	2.46690708
56	Palpitations (HP:0001962)	2.45093215
57	Deformed tarsal bones (HP:0008119)	2.43482794
58	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.42130007
59	Fetal akinesia sequence (HP:0001989)	2.40338343
60	Bundle branch block (HP:0011710)	2.40029415
61	Aortic dissection (HP:0002647)	2.39667340
62	Weak cry (HP:0001612)	2.39388052
63	Abnormal finger flexion creases (HP:0006143)	2.37394765
64	Muscular dystrophy (HP:0003560)	2.36016461
65	Hyperkalemia (HP:0002153)	2.26778255
66	Foot dorsiflexor weakness (HP:0009027)	2.22930706
67	Heart block (HP:0012722)	2.20089497
68	Abnormal atrioventricular conduction (HP:0005150)	2.16657910
69	Mildly elevated creatine phosphokinase (HP:0008180)	2.16503568
70	Abnormality of the foot musculature (HP:0001436)	2.13862943
71	Distal lower limb amyotrophy (HP:0008944)	2.11024316
72	Abnormality of the shoulder girdle musculature (HP:0001435)	2.08025246
73	Lip pit (HP:0100267)	2.04540664
74	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.03457665
75	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.03457665
76	Limited hip movement (HP:0008800)	2.02840707
77	Limb-girdle muscle weakness (HP:0003325)	2.02737515
78	Generalized muscle weakness (HP:0003324)	2.02648266
79	Facial diplegia (HP:0001349)	1.99520466
80	Waddling gait (HP:0002515)	1.97939838
81	Nonprogressive disorder (HP:0003680)	1.97164248
82	Palmoplantar keratoderma (HP:0000982)	1.96533707
83	Protrusio acetabuli (HP:0003179)	1.94320023
84	Spinal rigidity (HP:0003306)	1.93251092
85	Limb-girdle muscle atrophy (HP:0003797)	1.93154131
86	Cerebral aneurysm (HP:0004944)	1.92622713
87	Periauricular skin pits (HP:0100277)	1.91731914
88	Preauricular pit (HP:0004467)	1.91731914
89	Malignant hyperthermia (HP:0002047)	1.91467731
90	Bulbar palsy (HP:0001283)	1.89395524
91	Bell-shaped thorax (HP:0001591)	1.87199248
92	Left ventricular hypertrophy (HP:0001712)	1.86610315
93	Abnormal EKG (HP:0003115)	1.86454368
94	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.84595058
95	Hip contracture (HP:0003273)	1.83414296
96	Lower limb amyotrophy (HP:0007210)	1.80683481
97	Atrioventricular block (HP:0001678)	1.78658580
98	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.76186954
99	Acute necrotizing encephalopathy (HP:0006965)	1.75655197
100	Proximal amyotrophy (HP:0007126)	1.75481499
101	Ventricular fibrillation (HP:0001663)	1.75391433
102	Broad metatarsal (HP:0001783)	1.73883240
103	Frequent falls (HP:0002359)	1.72004290
104	Aplasia cutis congenita (HP:0001057)	1.68390233
105	Atrophic scars (HP:0001075)	1.68357261
106	Abnormality of the hip-girdle musculature (HP:0001445)	1.67441711
107	Abnormality of the musculature of the pelvis (HP:0001469)	1.67441711
108	Hypoplasia of the iris (HP:0007676)	1.65920148
109	EMG: neuropathic changes (HP:0003445)	1.65733657
110	Steppage gait (HP:0003376)	1.65726090
111	Abnormal mitochondria in muscle tissue (HP:0008316)	1.64164774
112	Arterial tortuosity (HP:0005116)	1.63943428
113	Long clavicles (HP:0000890)	1.62176360
114	Vascular tortuosity (HP:0004948)	1.61373135
115	Aneurysm (HP:0002617)	1.57651668
116	Abnormality of the calcaneus (HP:0008364)	1.55717696
117	Aplasia of the musculature (HP:0100854)	1.52176923
118	Oligomenorrhea (HP:0000876)	1.49169346

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	OBSCN	6.70899040
2	TTN	4.98014107
3	PHKG2	3.87366362
4	PHKG1	3.87366362
5	STK39	3.33071189
6	PIK3CA	2.76156163
7	DMPK	2.72113675
8	EPHB1	2.65399714
9	MYLK	2.55457315
10	PIK3CG	2.11398472
11	MUSK	2.03576771
12	TRPM7	1.98437344
13	NME1	1.90156896
14	ZAK	1.82244528
15	OXSR1	1.63605813
16	PKN1	1.50804680
17	MAP3K7	1.42818633
18	PINK1	1.39393526
19	LIMK1	1.36432450
20	PAK3	1.33019596
21	CAMK2D	1.31264292
22	LMTK2	1.27628565
23	WNK4	1.27078536
24	ERBB3	1.25144602
25	WNK1	1.16046639
26	MST4	1.11930823
27	MAP2K3	1.11109487
28	MARK1	1.09139917
29	INSRR	1.08955570
30	FER	1.05936209
31	ROCK2	1.02966689
32	PRKD1	1.02349543
33	PDK2	1.01642875
34	PDK3	0.98595974
35	PDK4	0.98595974
36	LATS2	0.97245357
37	MAPK15	0.94508519
38	BCR	0.92739364
39	MET	0.92574129
40	MAP3K3	0.91654049
41	ROCK1	0.90418099
42	CAMK2G	0.89304218
43	TNIK	0.87256117
44	GRK7	0.87119654
45	PDGFRA	0.86600869
46	DDR2	0.82958091
47	MAPK12	0.80868626
48	PTK2	0.80630377
49	MOS	0.80200776
50	TRIB3	0.78842515
51	PRKAA2	0.78761457
52	SGK3	0.77069082
53	PAK2	0.75308517
54	LATS1	0.74197546
55	AKT3	0.73931841
56	STK38L	0.72660832
57	EEF2K	0.72332536
58	NEK6	0.67877081
59	PBK	0.66836734
60	CAMK2B	0.66486592
61	MAPKAPK5	0.65271764
62	STK38	0.64233864
63	EPHA3	0.64162669
64	MAP3K6	0.63137440
65	BCKDK	0.63125803
66	SGK2	0.62653337
67	MAPK4	0.61114725
68	CAMK2A	0.60693593
69	PRKCE	0.60421852
70	TESK1	0.60084868
71	STK24	0.59895093
72	TIE1	0.58854159
73	JAK1	0.56295027
74	CDK19	0.55712373
75	NLK	0.55507111
76	SIK1	0.54923016
77	CLK1	0.54134407
78	MTOR	0.53952315
79	ILK	0.52350897
80	PRPF4B	0.52344573
81	PTK2B	0.51107695
82	BMPR2	0.50976310
83	CDC42BPA	0.49441495
84	MAP3K13	0.48923547
85	EPHA2	0.48896061
86	CAMK1G	0.47103605
87	EPHB2	0.45563749
88	FGFR2	0.45309293
89	PRKAA1	0.43747504
90	MAP2K6	0.43552232
91	IRAK1	0.43421852
92	CAMK1	0.41575807
93	PRKACB	0.41323774
94	PRKG1	0.41123603
95	STK4	0.40552373
96	PDGFRB	0.36953198
97	MAP2K4	0.36718790
98	MAPK7	0.36411380
99	PRKACA	0.36146907
100	MARK2	0.35648064
101	SGK223	0.34982576
102	SGK494	0.34982576
103	MAPK11	0.34852786
104	UHMK1	0.34664244
105	PRKCQ	0.33944413
106	NUAK1	0.33504184
107	FGFR3	0.33445110
108	RIPK1	0.31736975
109	TBK1	0.31614611
110	ICK	0.31267117
111	PRKD2	0.31255250
112	RPS6KA2	0.30289280
113	HIPK2	0.28749387
114	TGFBR2	0.28171694
115	SGK1	0.27933803
116	AKT2	0.27608705
117	CCNB1	0.27524109
118	MAPKAPK3	0.27324710
119	MELK	0.27132849
120	MAP3K12	0.26376461
121	MARK3	0.26313272
122	PAK6	0.25660838
123	ADRBK1	0.25271597
124	CSNK1A1L	0.25176851
125	MST1R	0.25158210
126	NEK9	0.23288158
127	IRAK2	0.22945224
128	RPS6KA3	0.22642720
129	GSK3A	0.22279957
130	MAP2K1	0.21894354
131	FRK	0.21814231
132	CAMK4	0.21792403
133	PDPK1	0.21684915
134	PKN2	0.21680494
135	MAPK10	0.21599471
136	MAP3K1	0.20521877

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	4.11796428
2	Dilated cardiomyopathy_Homo sapiens_hsa05414	3.82943889
3	Cardiac muscle contraction_Homo sapiens_hsa04260	3.79802481
4	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.46557840
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.69788608
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.45529258
7	Parkinsons disease_Homo sapiens_hsa05012	2.37541997
8	Sulfur metabolism_Homo sapiens_hsa00920	2.19483771
9	Alzheimers disease_Homo sapiens_hsa05010	2.15496633
10	Fatty acid elongation_Homo sapiens_hsa00062	2.01252334
11	Propanoate metabolism_Homo sapiens_hsa00640	1.94817524
12	Tight junction_Homo sapiens_hsa04530	1.93762000
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.78346638
14	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.65840306
15	ECM-receptor interaction_Homo sapiens_hsa04512	1.51404080
16	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.47782852
17	Focal adhesion_Homo sapiens_hsa04510	1.35578555
18	Viral myocarditis_Homo sapiens_hsa05416	1.33601402
19	Huntingtons disease_Homo sapiens_hsa05016	1.26966120
20	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.26289461
21	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.25901055
22	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.25115818
23	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.22939584
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21538684
25	Calcium signaling pathway_Homo sapiens_hsa04020	1.15430129
26	Fatty acid degradation_Homo sapiens_hsa00071	1.14563599
27	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.12494372
28	Adherens junction_Homo sapiens_hsa04520	1.11524576
29	Leukocyte transendothelial migration_Homo sapiens_hsa04670	1.10918940
30	Fatty acid metabolism_Homo sapiens_hsa01212	1.09825201
31	Circadian rhythm_Homo sapiens_hsa04710	1.04885835
32	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.04169314
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.02754491
34	Insulin resistance_Homo sapiens_hsa04931	0.99494534
35	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.98963786
36	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.97478668
37	Ether lipid metabolism_Homo sapiens_hsa00565	0.96916423
38	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.96146703
39	Butanoate metabolism_Homo sapiens_hsa00650	0.92953100
40	Gastric acid secretion_Homo sapiens_hsa04971	0.92900495
41	Axon guidance_Homo sapiens_hsa04360	0.89333647
42	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.88509361
43	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.86892349
44	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.86080477
45	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85446729
46	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.82908794
47	Long-term potentiation_Homo sapiens_hsa04720	0.82416392
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.82113662
49	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.81587642
50	Renal cell carcinoma_Homo sapiens_hsa05211	0.80582180
51	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.80115733
52	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.79529683
53	Insulin signaling pathway_Homo sapiens_hsa04910	0.79118959
54	mTOR signaling pathway_Homo sapiens_hsa04150	0.76600160
55	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.75834928
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75117627
57	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.74201582
58	Linoleic acid metabolism_Homo sapiens_hsa00591	0.73523799
59	Amoebiasis_Homo sapiens_hsa05146	0.72656654
60	Pentose phosphate pathway_Homo sapiens_hsa00030	0.70721224
61	Glucagon signaling pathway_Homo sapiens_hsa04922	0.70066351
62	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69873495
63	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.69631406
64	Renin secretion_Homo sapiens_hsa04924	0.68912760
65	AMPK signaling pathway_Homo sapiens_hsa04152	0.68749721
66	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.67891733
67	PPAR signaling pathway_Homo sapiens_hsa03320	0.65908773
68	Proteoglycans in cancer_Homo sapiens_hsa05205	0.64823339
69	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.64537970
70	Sphingolipid metabolism_Homo sapiens_hsa00600	0.63746501
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62300703
72	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.62296246
73	Protein digestion and absorption_Homo sapiens_hsa04974	0.61737283
74	Glioma_Homo sapiens_hsa05214	0.61463471
75	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.60209717
76	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59395259
77	Amphetamine addiction_Homo sapiens_hsa05031	0.58611136
78	Carbon metabolism_Homo sapiens_hsa01200	0.58604042
79	Bacterial invasion of epithelial cells_Homo sapiens_hsa05100	0.58106134
80	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.57254921
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.56895917
82	Phenylalanine metabolism_Homo sapiens_hsa00360	0.56538318
83	Mineral absorption_Homo sapiens_hsa04978	0.56405305
84	Arginine biosynthesis_Homo sapiens_hsa00220	0.55921043
85	ABC transporters_Homo sapiens_hsa02010	0.55707180
86	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.54570582
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.54368837
88	Hippo signaling pathway_Homo sapiens_hsa04390	0.53509690
89	Lysine degradation_Homo sapiens_hsa00310	0.52582143
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.52482922
91	Nitrogen metabolism_Homo sapiens_hsa00910	0.52299922
92	cAMP signaling pathway_Homo sapiens_hsa04024	0.52010941
93	Estrogen signaling pathway_Homo sapiens_hsa04915	0.51580583
94	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.49937576
95	Small cell lung cancer_Homo sapiens_hsa05222	0.48370241
96	MAPK signaling pathway_Homo sapiens_hsa04010	0.48224472
97	GnRH signaling pathway_Homo sapiens_hsa04912	0.47744789
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47430899
99	Melanoma_Homo sapiens_hsa05218	0.46685974
100	VEGF signaling pathway_Homo sapiens_hsa04370	0.45979017
101	Endometrial cancer_Homo sapiens_hsa05213	0.45357811
102	Platelet activation_Homo sapiens_hsa04611	0.44724991
103	Salivary secretion_Homo sapiens_hsa04970	0.44265067
104	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.43988762
105	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.43713086
106	Serotonergic synapse_Homo sapiens_hsa04726	0.43437504
107	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.42529328
108	Cholinergic synapse_Homo sapiens_hsa04725	0.41882263
109	Gap junction_Homo sapiens_hsa04540	0.41558727
110	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.41290836
111	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.41068050
112	Ras signaling pathway_Homo sapiens_hsa04014	0.40510322
113	Toxoplasmosis_Homo sapiens_hsa05145	0.40274662
114	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40231650
115	Pancreatic secretion_Homo sapiens_hsa04972	0.39350329
116	Melanogenesis_Homo sapiens_hsa04916	0.38538918
117	PI3K-Akt signaling pathway_Homo sapiens_hsa04151	0.37900311
118	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37852428
119	Galactose metabolism_Homo sapiens_hsa00052	0.37384480
120	TNF signaling pathway_Homo sapiens_hsa04668	0.37324561
121	Choline metabolism in cancer_Homo sapiens_hsa05231	0.36960809
122	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.36552794
123	Pancreatic cancer_Homo sapiens_hsa05212	0.36384345
124	Long-term depression_Homo sapiens_hsa04730	0.35585738
125	Notch signaling pathway_Homo sapiens_hsa04330	0.35270372
126	Wnt signaling pathway_Homo sapiens_hsa04310	0.34575666
127	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.33953709
128	Pyruvate metabolism_Homo sapiens_hsa00620	0.33748651
129	Circadian entrainment_Homo sapiens_hsa04713	0.33060492
130	Bile secretion_Homo sapiens_hsa04976	0.32653246
131	Type II diabetes mellitus_Homo sapiens_hsa04930	0.32213755
132	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.31821827
133	Histidine metabolism_Homo sapiens_hsa00340	0.31652773
134	Rheumatoid arthritis_Homo sapiens_hsa05323	0.31269256
135	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.31266701
136	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.30295114
137	Rap1 signaling pathway_Homo sapiens_hsa04015	0.29536925
138	ErbB signaling pathway_Homo sapiens_hsa04012	0.29310848
139	* FoxO signaling pathway_Homo sapiens_hsa04068	0.28670939
140	Pathways in cancer_Homo sapiens_hsa05200	0.28557937
141	Insulin secretion_Homo sapiens_hsa04911	0.27191498
142	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.26911507

FBXO32

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »