FBXO33

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents an member of the F-box gene family. The encoded protein contains an F-box motif and a domain that might form a structure similar to a leucine-rich repeat found in placental RNAse inhibitor. This locus may be associated with copy number variation of UGT2B17 (GeneID 7367), which has been associated with susceptibility to osteoporosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.00520598
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.00520598
3neuronal action potential propagation (GO:0019227)4.05539878
4gamma-aminobutyric acid signaling pathway (GO:0007214)4.00844896
5ionotropic glutamate receptor signaling pathway (GO:0035235)3.78504527
6interferon-gamma production (GO:0032609)3.76560980
7regulation of interferon-beta biosynthetic process (GO:0045357)3.70392041
8regulation of establishment of cell polarity (GO:2000114)3.64749507
9peptidyl-threonine dephosphorylation (GO:0035970)3.64632634
10positive T cell selection (GO:0043368)3.62051296
11RNA destabilization (GO:0050779)3.57009924
12glutamate receptor signaling pathway (GO:0007215)3.56370599
13regulation of germinal center formation (GO:0002634)3.45089489
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.44234621
15positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.42721253
16negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.35938145
17regulation of synaptic vesicle exocytosis (GO:2000300)3.29474090
18positive thymic T cell selection (GO:0045059)3.25723540
19negative T cell selection (GO:0043383)3.22598839
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.19684276
21response to histamine (GO:0034776)3.19602613
22retrograde transport, vesicle recycling within Golgi (GO:0000301)3.18152644
23B cell receptor signaling pathway (GO:0050853)3.10227585
24tolerance induction (GO:0002507)3.09563080
25negative thymic T cell selection (GO:0045060)3.09375480
26regulation of synaptic vesicle transport (GO:1902803)3.09173599
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.09100875
28regulation of neuron projection regeneration (GO:0070570)3.08819869
29regulation of axon regeneration (GO:0048679)3.08819869
30positive regulation of interferon-alpha production (GO:0032727)3.08397571
31negative regulation of inclusion body assembly (GO:0090084)3.04592367
32cellular extravasation (GO:0045123)3.04424710
33regulation of interferon-alpha production (GO:0032647)3.04021178
34negative regulation of hormone biosynthetic process (GO:0032353)3.03773009
35negative regulation of hormone metabolic process (GO:0032351)3.03773009
36protein targeting to Golgi (GO:0000042)3.01648419
37regulation of T cell tolerance induction (GO:0002664)2.98459121
38antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.98259432
39regulation of gamma-delta T cell activation (GO:0046643)2.97187460
40antigen processing and presentation of endogenous antigen (GO:0019883)2.96399107
41regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.95887602
42positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.95427283
43T cell migration (GO:0072678)2.94341332
44regulation of memory T cell differentiation (GO:0043380)2.90631829
45neutrophil mediated immunity (GO:0002446)2.88664961
46synaptic vesicle exocytosis (GO:0016079)2.88316014
47establishment of protein localization to Golgi (GO:0072600)2.87304930
48neuron-neuron synaptic transmission (GO:0007270)2.86508046
49histone H2B ubiquitination (GO:0033523)2.85810261
50glycerophospholipid catabolic process (GO:0046475)2.85099228
51negative regulation of B cell proliferation (GO:0030889)2.85096006
52regulation of establishment or maintenance of cell polarity (GO:0032878)2.84926166
53B cell homeostasis (GO:0001782)2.83140221
54regulation of alpha-beta T cell proliferation (GO:0046640)2.82283246
55synaptic transmission, glutamatergic (GO:0035249)2.81418163
56protein K11-linked deubiquitination (GO:0035871)2.80821487
57regulation of sequestering of triglyceride (GO:0010889)2.80589472
58positive regulation of tolerance induction (GO:0002645)2.80301835
59cellular response to ethanol (GO:0071361)2.79359463
60regulation of T-helper 1 cell differentiation (GO:0045625)2.78567376
61positive regulation of interferon-beta production (GO:0032728)2.78032874
62protein localization to synapse (GO:0035418)2.75132668
63presynaptic membrane assembly (GO:0097105)2.74741391
64negative regulation of T-helper cell differentiation (GO:0045623)2.74358383
65negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.74358383
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.73984523
67T cell mediated immunity (GO:0002456)2.72817580
68positive regulation of macroautophagy (GO:0016239)2.72674610
69inner ear receptor cell differentiation (GO:0060113)2.72502480
70regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72284616
71neutrophil activation involved in immune response (GO:0002283)2.71745479
72glutamate secretion (GO:0014047)2.71372276
73positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.69560132
74cellular response to exogenous dsRNA (GO:0071360)2.69281980
75positive regulation of B cell differentiation (GO:0045579)2.68633785
76neuron cell-cell adhesion (GO:0007158)2.68371339
77regulation of clathrin-mediated endocytosis (GO:2000369)2.68144371
78mast cell activation (GO:0045576)2.67784907
79type I interferon signaling pathway (GO:0060337)2.67750293
80cellular response to type I interferon (GO:0071357)2.67750293
81negative regulation of neurotransmitter transport (GO:0051589)2.66003594
82regulation of gamma-delta T cell differentiation (GO:0045586)2.65423746
83regulation of tolerance induction (GO:0002643)2.64945626
84long-term memory (GO:0007616)2.64315866
85positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64167307
86response to type I interferon (GO:0034340)2.63897363
87negative regulation of lymphocyte mediated immunity (GO:0002707)2.62813397
88regulation of B cell receptor signaling pathway (GO:0050855)2.60824046
89regulation of mast cell activation (GO:0033003)2.60384637
90I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.59420630
91auditory receptor cell differentiation (GO:0042491)2.59403434
92positive regulation of interleukin-12 production (GO:0032735)2.59338162
93negative regulation of exocytosis (GO:0045920)2.59184100
94interferon-gamma secretion (GO:0072643)2.58927354
95ER overload response (GO:0006983)2.58789410
96long-term synaptic potentiation (GO:0060291)2.58338130
97regulation of glutamate receptor signaling pathway (GO:1900449)2.58244386
98positive regulation of alpha-beta T cell proliferation (GO:0046641)2.58117841
99regulation of B cell differentiation (GO:0045577)2.57989330
100antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.57823027
101regulation of cell proliferation involved in kidney development (GO:1901722)2.57707565
102negative regulation of synaptic transmission, GABAergic (GO:0032229)2.57289816
103DNA deamination (GO:0045006)2.57193044
104T cell selection (GO:0045058)2.57149811
105activated T cell proliferation (GO:0050798)2.57011114
106immunoglobulin mediated immune response (GO:0016064)2.55913811
107startle response (GO:0001964)2.55696271
108myeloid leukocyte mediated immunity (GO:0002444)2.55532577
109regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.55389332
110neutrophil activation (GO:0042119)2.55022276
111regulation of B cell apoptotic process (GO:0002902)2.54984810
112negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.53936353
113cellular response to interleukin-15 (GO:0071350)2.53641873
114regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.53272076
115regulation of T cell mediated cytotoxicity (GO:0001914)2.52179166
116response to interleukin-15 (GO:0070672)2.51426182
117neuromuscular process controlling posture (GO:0050884)2.50808921
118G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.49746058
119interferon-gamma-mediated signaling pathway (GO:0060333)2.49685331
120serotonin metabolic process (GO:0042428)2.49553229
121regulation of T cell receptor signaling pathway (GO:0050856)2.48691356
122macrophage activation (GO:0042116)2.48287695
123regulation of interferon-beta production (GO:0032648)2.47487116
124regulation of RNA export from nucleus (GO:0046831)2.46997715
125germinal center formation (GO:0002467)2.46995487
126phagosome maturation (GO:0090382)2.46734825
127negative regulation of amino acid transport (GO:0051956)2.45391072
128dentate gyrus development (GO:0021542)2.44317015
129negative regulation of interleukin-12 production (GO:0032695)2.44316467
130regulation of B cell proliferation (GO:0030888)2.43757446
131positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.43014318
132leukocyte aggregation (GO:0070486)2.42249109
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.42109541
134detection of molecule of bacterial origin (GO:0032490)2.40835131
135adaptation of signaling pathway (GO:0023058)2.40607995
136microglial cell activation (GO:0001774)2.40556211
137negative regulation of neurotransmitter secretion (GO:0046929)2.40387863
138regulation of glutamate secretion (GO:0014048)2.39600117
139monoubiquitinated protein deubiquitination (GO:0035520)2.39229959
140regulation of neuronal synaptic plasticity (GO:0048168)2.38445353
141regulation of nucleobase-containing compound transport (GO:0032239)2.37705110
142cerebellar Purkinje cell differentiation (GO:0021702)2.37536777
143proline transport (GO:0015824)2.36477631
144positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.35737418
145negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.34438318
146vesicle transport along microtubule (GO:0047496)2.34437246
147positive regulation of gamma-delta T cell activation (GO:0046645)2.34051055
148negative regulation of meiotic cell cycle (GO:0051447)2.33855162
149locomotory exploration behavior (GO:0035641)2.33545862
150regulation of regulatory T cell differentiation (GO:0045589)2.31320762
151negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.28764357
152regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.28516120
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.27662392
154inositol phosphate dephosphorylation (GO:0046855)2.27662392
155myeloid cell activation involved in immune response (GO:0002275)2.27280168
156presynaptic membrane organization (GO:0097090)2.25983295
157long term synaptic depression (GO:0060292)2.25230203
158positive regulation of response to oxidative stress (GO:1902884)2.25053235
159positive regulation of cellular response to oxidative stress (GO:1900409)2.25053235
160negative regulation of T cell mediated immunity (GO:0002710)2.24760245
161intracellular pH reduction (GO:0051452)2.24628273
162positive regulation by symbiont of host defense response (GO:0052509)2.23945887
163modulation by symbiont of host defense response (GO:0052031)2.23945887
164modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.23945887
165modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.23945887
166positive regulation by organism of defense response of other organism involved in symbiotic interact2.23945887
167modulation by symbiont of host immune response (GO:0052553)2.23945887
168negative regulation of type 2 immune response (GO:0002829)2.23571988
169macrophage activation involved in immune response (GO:0002281)2.23543338
170regulation of isotype switching to IgG isotypes (GO:0048302)2.22682604
171righting reflex (GO:0060013)2.22418865
172megakaryocyte development (GO:0035855)2.21915010
173positive regulation of membrane potential (GO:0045838)2.20901791
174regulation of meiotic cell cycle (GO:0051445)2.20660368
175negative regulation of T cell receptor signaling pathway (GO:0050860)2.20609108
176piRNA metabolic process (GO:0034587)2.19235896
177neurotransmitter secretion (GO:0007269)2.19053087
178regulation of vesicle fusion (GO:0031338)2.18609769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.69214255
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.85922462
3POU3F2_20337985_ChIP-ChIP_501MEL_Human2.74176275
4IGF1R_20145208_ChIP-Seq_DFB_Human2.72243085
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.69020139
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68521831
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63817102
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.59678566
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54002058
10EZH2_22144423_ChIP-Seq_EOC_Human2.52359862
11TAF15_26573619_Chip-Seq_HEK293_Human2.48114093
12GBX2_23144817_ChIP-Seq_PC3_Human2.46980125
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.36255935
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.32607197
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.32186721
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23859824
17VDR_22108803_ChIP-Seq_LS180_Human2.09975504
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.09330263
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.08680520
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.04572583
21FUS_26573619_Chip-Seq_HEK293_Human1.98636187
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97247706
23* P300_19829295_ChIP-Seq_ESCs_Human1.86950637
24* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86182458
25Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.85562455
26MYB_26560356_Chip-Seq_TH2_Human1.84475719
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.83885227
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.83359180
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.82340419
30SMAD4_21799915_ChIP-Seq_A2780_Human1.81644955
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76535494
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76301231
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75492788
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70136382
35VDR_24787735_ChIP-Seq_THP-1_Human1.65881125
36* ER_23166858_ChIP-Seq_MCF-7_Human1.65081051
37REST_21632747_ChIP-Seq_MESCs_Mouse1.64849619
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.64487871
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.57965614
40SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57034121
41GATA3_27048872_Chip-Seq_THYMUS_Human1.56692837
42* MYB_26560356_Chip-Seq_TH1_Human1.55996610
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.54378549
44* EWS_26573619_Chip-Seq_HEK293_Human1.54352414
45* IRF8_27001747_Chip-Seq_BMDM_Mouse1.53081368
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.51338283
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50867125
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50739050
49GATA3_26560356_Chip-Seq_TH2_Human1.48932160
50TP53_16413492_ChIP-PET_HCT116_Human1.44751421
51P53_22387025_ChIP-Seq_ESCs_Mouse1.43301085
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.42739854
53AR_25329375_ChIP-Seq_VCAP_Human1.42225053
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41868085
55* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.41620594
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.41058705
57STAT3_23295773_ChIP-Seq_U87_Human1.40126249
58PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38760045
59* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38167788
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.38016815
61RARB_27405468_Chip-Seq_BRAIN_Mouse1.37884094
62E2F1_18555785_Chip-Seq_ESCs_Mouse1.35824877
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.35716279
64RNF2_27304074_Chip-Seq_NSC_Mouse1.35025853
65RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.32448125
66PRDM14_20953172_ChIP-Seq_ESCs_Human1.31756201
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.30517157
68UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30466475
69SUZ12_18555785_Chip-Seq_ESCs_Mouse1.27865206
70* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.27440706
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.26321688
72NMYC_18555785_Chip-Seq_ESCs_Mouse1.25552114
73AR_21572438_ChIP-Seq_LNCaP_Human1.24885583
74STAT3_18555785_Chip-Seq_ESCs_Mouse1.23411769
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22993687
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21667164
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.21654613
78SALL1_21062744_ChIP-ChIP_HESCs_Human1.21544315
79SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21385116
80* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20023311
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18528012
82SPI1_23547873_ChIP-Seq_NB4_Human1.17300703
83P300_18555785_Chip-Seq_ESCs_Mouse1.17068423
84* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15733767
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15292957
86LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15216228
87* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14561314
88TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14388779
89RUNX2_22187159_ChIP-Seq_PCA_Human1.14376086
90RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13766622
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13677815
92SMRT_27268052_Chip-Seq_Bcells_Human1.13665248
93* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13194009
94* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.11052668
95* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.10803152
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09150523
97RUNX_20019798_ChIP-Seq_JUKART_Human1.09008546
98* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.07782996
99TCF4_23295773_ChIP-Seq_U87_Human1.06630774
100PU1_27457419_Chip-Seq_LIVER_Mouse1.05678059
101* FLI1_21867929_ChIP-Seq_TH2_Mouse1.05130987
102OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05087624
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04040526
104KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03769910
105JUN_21703547_ChIP-Seq_K562_Human1.02247793
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02013316
107SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01948236
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01888509
109KDM2B_26808549_Chip-Seq_REH_Human1.01744278
110BCAT_22108803_ChIP-Seq_LS180_Human1.01739479
111PCGF2_27294783_Chip-Seq_NPCs_Mouse1.01530057
112* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.01503292
113OCT4_18555785_Chip-Seq_ESCs_Mouse1.00675760
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00474764
115CRX_20693478_ChIP-Seq_RETINA_Mouse1.00033867
116* ARNT_22903824_ChIP-Seq_MCF-7_Human0.99616561
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98626793
118SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97346275
119ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96943141
120KLF4_18555785_Chip-Seq_ESCs_Mouse0.96729576
121MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96485442
122* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96088082
123CDX2_22108803_ChIP-Seq_LS180_Human0.95266022
124CBP_20019798_ChIP-Seq_JUKART_Human0.94276259
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94276259
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94257146
127LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88963344
128E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88783936
129AHR_22903824_ChIP-Seq_MCF-7_Human0.88776189
130ZNF274_21170338_ChIP-Seq_K562_Hela0.88210323
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.87448536
132* PU_27001747_Chip-Seq_BMDM_Mouse0.87184552
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87035445
134POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.87035445
135SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.85817636
136GATA3_26560356_Chip-Seq_TH1_Human0.81123864
137* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80995974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.16420509
2MP0004859_abnormal_synaptic_plasticity3.60721570
3MP0002138_abnormal_hepatobiliary_system3.09006071
4MP0001501_abnormal_sleep_pattern3.03299272
5MP0003635_abnormal_synaptic_transmissio2.80771934
6MP0009046_muscle_twitch2.65271420
7MP0005310_abnormal_salivary_gland2.55392331
8MP0003787_abnormal_imprinting2.49038581
9MP0009745_abnormal_behavioral_response2.48837166
10MP0002064_seizures2.45469075
11MP0003303_peritoneal_inflammation2.30083146
12MP0008057_abnormal_DNA_replication2.27472952
13MP0003172_abnormal_lysosome_physiology2.25686138
14MP0008877_abnormal_DNA_methylation2.14757711
15MP0002063_abnormal_learning/memory/cond2.11235874
16MP0002572_abnormal_emotion/affect_behav1.92230504
17MP0002272_abnormal_nervous_system1.90648976
18MP0002166_altered_tumor_susceptibility1.87501012
19MP0002837_dystrophic_cardiac_calcinosis1.86014488
20MP0001440_abnormal_grooming_behavior1.83742956
21MP0001968_abnormal_touch/_nociception1.81467588
22MP0005671_abnormal_response_to1.79432231
23MP0003646_muscle_fatigue1.74301743
24MP0004270_analgesia1.74287060
25MP0002254_reproductive_system_inflammat1.73133812
26MP0003724_increased_susceptibility_to1.71842421
27MP0005000_abnormal_immune_tolerance1.71839779
28MP0000569_abnormal_digit_pigmentation1.71164381
29MP0003123_paternal_imprinting1.67889643
30MP0001835_abnormal_antigen_presentation1.66144840
31MP0010386_abnormal_urinary_bladder1.65818223
32MP0006082_CNS_inflammation1.61193913
33MP0006292_abnormal_olfactory_placode1.60494874
34MP0005174_abnormal_tail_pigmentation1.56334246
35MP0001188_hyperpigmentation1.55434810
36MP0005423_abnormal_somatic_nervous1.53910402
37MP0001529_abnormal_vocalization1.50986547
38MP0002139_abnormal_hepatobiliary_system1.49795773
39MP0002736_abnormal_nociception_after1.46168302
40MP0002148_abnormal_hypersensitivity_rea1.45807846
41MP0005075_abnormal_melanosome_morpholog1.44737792
42MP0002723_abnormal_immune_serum1.44277762
43MP0005379_endocrine/exocrine_gland_phen1.43323114
44MP0004510_myositis1.42754581
45MP0003045_fibrosis1.39598799
46MP0001486_abnormal_startle_reflex1.39237310
47MP0005646_abnormal_pituitary_gland1.37397402
48MP0002163_abnormal_gland_morphology1.35616342
49MP0010234_abnormal_vibrissa_follicle1.34650477
50MP0005387_immune_system_phenotype1.34415281
51MP0001790_abnormal_immune_system1.34415281
52MP0004947_skin_inflammation1.31746805
53MP0003879_abnormal_hair_cell1.31488612
54MP0002734_abnormal_mechanical_nocicepti1.28868099
55MP0009785_altered_susceptibility_to1.28449788
56MP0001800_abnormal_humoral_immune1.28104893
57MP0001944_abnormal_pancreas_morphology1.27944481
58MP0002419_abnormal_innate_immunity1.26531186
59MP0001851_eye_inflammation1.26515079
60MP0002452_abnormal_antigen_presenting1.26283571
61MP0004134_abnormal_chest_morphology1.26255589
62MP0002420_abnormal_adaptive_immunity1.25544267
63MP0003436_decreased_susceptibility_to1.24531984
64MP0001819_abnormal_immune_cell1.24258414
65MP0002067_abnormal_sensory_capabilities1.22373304
66MP0002877_abnormal_melanocyte_morpholog1.20421900
67MP0002735_abnormal_chemical_nociception1.19839667
68MP0000685_abnormal_immune_system1.19404401
69MP0005464_abnormal_platelet_physiology1.17989376
70MP0003300_gastrointestinal_ulcer1.17469520
71MP0004924_abnormal_behavior1.16504065
72MP0005386_behavior/neurological_phenoty1.16504065
73MP0002009_preneoplasia1.16305619
74MP0002693_abnormal_pancreas_physiology1.13945293
75MP0003252_abnormal_bile_duct1.13904583
76MP0001970_abnormal_pain_threshold1.13887157
77MP0002006_tumorigenesis1.12084412
78MP0006276_abnormal_autonomic_nervous1.11557594
79MP0005167_abnormal_blood-brain_barrier1.10409163
80MP0001905_abnormal_dopamine_level1.10094104
81MP0002277_abnormal_respiratory_mucosa1.08804241
82MP0003195_calcinosis1.08596436
83MP0004742_abnormal_vestibular_system1.08576170
84MP0002405_respiratory_system_inflammati1.07379932
85MP0002398_abnormal_bone_marrow1.05565571
86MP0001919_abnormal_reproductive_system1.05034043
87MP0002429_abnormal_blood_cell1.04123007
88MP0002396_abnormal_hematopoietic_system1.04057132
89MP0001502_abnormal_circadian_rhythm1.03953979
90MP0002876_abnormal_thyroid_physiology1.02160137
91MP0001533_abnormal_skeleton_physiology1.01329776
92MP0005025_abnormal_response_to1.00377138
93MP0002733_abnormal_thermal_nociception0.98984408
94MP0002638_abnormal_pupillary_reflex0.98692350
95MP0000716_abnormal_immune_system0.97348712
96MP0002928_abnormal_bile_duct0.97268980
97MP0003690_abnormal_glial_cell0.97094068
98MP0003136_yellow_coat_color0.97076729
99MP0005389_reproductive_system_phenotype0.96714004
100MP0004885_abnormal_endolymph0.95632804
101MP0009764_decreased_sensitivity_to0.95481734
102MP0000372_irregular_coat_pigmentation0.95131618
103MP0003786_premature_aging0.95103307
104MP0003763_abnormal_thymus_physiology0.93601711
105MP0008961_abnormal_basal_metabolism0.92899296
106MP0001765_abnormal_ion_homeostasis0.90693656
107MP0008469_abnormal_protein_level0.90071539
108MP0009780_abnormal_chondrocyte_physiolo0.87128686
109MP0008569_lethality_at_weaning0.86806414
110MP0000604_amyloidosis0.85820371
111MP0005535_abnormal_body_temperature0.85494515
112MP0001929_abnormal_gametogenesis0.84520680
113MP0006072_abnormal_retinal_apoptosis0.83758543
114MP0002557_abnormal_social/conspecific_i0.83532198
115MP0005410_abnormal_fertilization0.83392333
116MP0000920_abnormal_myelination0.82996558
117MP0000631_abnormal_neuroendocrine_gland0.82897337
118MP0000703_abnormal_thymus_morphology0.82529388
119MP0000689_abnormal_spleen_morphology0.81849169
120MP0005084_abnormal_gallbladder_morpholo0.81727765
121MP0000015_abnormal_ear_pigmentation0.81722113
122MP0003075_altered_response_to0.81253178
123MP0001845_abnormal_inflammatory_respons0.81213328
124MP0003633_abnormal_nervous_system0.81199817
125MP0000371_diluted_coat_color0.80570507
126MP0005166_decreased_susceptibility_to0.79591308
127MP0002184_abnormal_innervation0.79588157
128MP0001853_heart_inflammation0.79534054
129MP0010155_abnormal_intestine_physiology0.78554659
130MP0003866_abnormal_defecation0.78063218
131MP0001873_stomach_inflammation0.77597165
132MP0003828_pulmonary_edema0.77036048
133MP0010307_abnormal_tumor_latency0.76955820
134MP0002066_abnormal_motor_capabilities/c0.76760941
135MP0004811_abnormal_neuron_physiology0.76576364
136MP0005645_abnormal_hypothalamus_physiol0.76493537
137MP0004142_abnormal_muscle_tone0.75925973
138MP0008874_decreased_physiological_sensi0.75730840
139MP0009333_abnormal_splenocyte_physiolog0.75449173
140MP0010678_abnormal_skin_adnexa0.75095980
141MP0004381_abnormal_hair_follicle0.74946643
142MP0002909_abnormal_adrenal_gland0.73309116
143MP0003448_altered_tumor_morphology0.73303062
144MP0002722_abnormal_immune_system0.72006314
145MP0005409_darkened_coat_color0.71556687
146MP0004130_abnormal_muscle_cell0.68527791

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.57220401
2Visual hallucinations (HP:0002367)4.66302061
3Atonic seizures (HP:0010819)4.28637211
4Febrile seizures (HP:0002373)4.23896794
5Abnormal hair whorl (HP:0010721)3.75623738
6Prostate neoplasm (HP:0100787)3.65813610
7Absence seizures (HP:0002121)3.61410328
8Focal seizures (HP:0007359)3.47214994
9Dialeptic seizures (HP:0011146)3.32037852
10Abnormal rod and cone electroretinograms (HP:0008323)3.19468537
11Rhinitis (HP:0012384)3.15238607
12Stomatitis (HP:0010280)3.00653025
13Generalized tonic-clonic seizures (HP:0002069)2.99907242
14IgG deficiency (HP:0004315)2.99500200
15Abnormal ciliary motility (HP:0012262)2.96727522
16Severe visual impairment (HP:0001141)2.95662603
17Hematochezia (HP:0002573)2.91495424
18Abnormal respiratory motile cilium physiology (HP:0012261)2.91219119
19Attenuation of retinal blood vessels (HP:0007843)2.89359139
20Submucous cleft hard palate (HP:0000176)2.82225041
21Conjunctival hamartoma (HP:0100780)2.80733393
22Absent rod-and cone-mediated responses on ERG (HP:0007688)2.79839237
23Autoimmune hemolytic anemia (HP:0001890)2.72945716
24Epileptic encephalopathy (HP:0200134)2.71763235
25Pustule (HP:0200039)2.70739679
26Methylmalonic acidemia (HP:0002912)2.69704366
27Birth length less than 3rd percentile (HP:0003561)2.65519302
28Optic neuritis (HP:0100653)2.63270216
29Retrobulbar optic neuritis (HP:0100654)2.63270216
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.62742579
31Recurrent skin infections (HP:0001581)2.62566353
32Elevated erythrocyte sedimentation rate (HP:0003565)2.61591710
33Abnormality of homocysteine metabolism (HP:0010919)2.60428700
34Homocystinuria (HP:0002156)2.60428700
35Progressive inability to walk (HP:0002505)2.53755421
36Eczematoid dermatitis (HP:0000976)2.51609494
37Recurrent abscess formation (HP:0002722)2.51005153
38Abnormality of the labia minora (HP:0012880)2.46950562
39Facial hemangioma (HP:0000329)2.46328661
40Inability to walk (HP:0002540)2.46243496
41Persistence of primary teeth (HP:0006335)2.45096753
42Abnormality of DNA repair (HP:0003254)2.44369045
43Vascular calcification (HP:0004934)2.43835338
44Recurrent bacterial skin infections (HP:0005406)2.43451353
45Abnormality of T cells (HP:0002843)2.42854670
46Obstructive lung disease (HP:0006536)2.40288374
47Chronic obstructive pulmonary disease (HP:0006510)2.40288374
48Abnormality of the prostate (HP:0008775)2.39391118
49Mediastinal lymphadenopathy (HP:0100721)2.39321886
50Abnormality of T cell physiology (HP:0011840)2.39050661
51Abolished electroretinogram (ERG) (HP:0000550)2.38347204
52Vasculitis (HP:0002633)2.36533928
53Episodic fever (HP:0001954)2.34746973
54Capillary hemangiomas (HP:0005306)2.30790602
55Abnormality of vitamin B metabolism (HP:0004340)2.29489175
56Mutism (HP:0002300)2.28387712
57Papilledema (HP:0001085)2.28130998
58Progressive cerebellar ataxia (HP:0002073)2.27837505
59Fair hair (HP:0002286)2.24993627
60Abnormality of binocular vision (HP:0011514)2.23586776
61Diplopia (HP:0000651)2.23586776
62Abnormality of B cell number (HP:0010975)2.23210549
63Encephalitis (HP:0002383)2.22973753
64Abnormality of the renal collecting system (HP:0004742)2.22268651
65Abnormal respiratory motile cilium morphology (HP:0005938)2.21764595
66Abnormal respiratory epithelium morphology (HP:0012253)2.21764595
67Inappropriate behavior (HP:0000719)2.20601154
68Generalized hypopigmentation of hair (HP:0011358)2.19356528
69Abnormal delayed hypersensitivity skin test (HP:0002963)2.18661584
70Absent speech (HP:0001344)2.18368775
71Congenital sensorineural hearing impairment (HP:0008527)2.17823456
72Neoplasm of the tracheobronchial system (HP:0100552)2.17519593
73Broad-based gait (HP:0002136)2.17454563
74Gaze-evoked nystagmus (HP:0000640)2.16763701
75Verrucae (HP:0200043)2.16584902
76Papilloma (HP:0012740)2.16584902
77Bony spicule pigmentary retinopathy (HP:0007737)2.15773436
78Protruding tongue (HP:0010808)2.13677896
79Recurrent bronchitis (HP:0002837)2.12957393
80Global brain atrophy (HP:0002283)2.12261576
81Metaphyseal dysplasia (HP:0100255)2.11546883
82Infertility (HP:0000789)2.10896221
83Facial shape deformation (HP:0011334)2.10890341
84Potter facies (HP:0002009)2.10890341
85Excessive salivation (HP:0003781)2.09997681
86Drooling (HP:0002307)2.09997681
87Panhypogammaglobulinemia (HP:0003139)2.09529749
88Dynein arm defect of respiratory motile cilia (HP:0012255)2.08749026
89Absent/shortened dynein arms (HP:0200106)2.08749026
90Asplenia (HP:0001746)2.07632720
91Adactyly (HP:0009776)2.07034289
92Widely spaced teeth (HP:0000687)2.06159616
93Increased neuronal autofluorescent lipopigment (HP:0002074)2.05847535
94Cardiovascular calcification (HP:0011915)2.05393366
95Orchitis (HP:0100796)2.05360745
96Genetic anticipation (HP:0003743)2.04511258
97Alveolar cell carcinoma (HP:0006519)2.04468994
98Stomach cancer (HP:0012126)2.02389561
99Generalized myoclonic seizures (HP:0002123)1.99798455
100Myositis (HP:0100614)1.99311446
101Recurrent gram-negative bacterial infections (HP:0005420)1.99037729
102Increased cerebral lipofuscin (HP:0011813)1.98512680
103T lymphocytopenia (HP:0005403)1.98436671
104Recurrent viral infections (HP:0004429)1.97902772
105Albinism (HP:0001022)1.97821896
106B lymphocytopenia (HP:0010976)1.97486363
107Bronchiectasis (HP:0002110)1.97418014
108Poor eye contact (HP:0000817)1.96875512
109Lymphopenia (HP:0001888)1.95680068
110Large for gestational age (HP:0001520)1.94513949
111Agammaglobulinemia (HP:0004432)1.93513050
112Furrowed tongue (HP:0000221)1.92860288
113Hamartoma of the eye (HP:0010568)1.92298136
114Cutaneous melanoma (HP:0012056)1.92285513
115Recurrent fungal infections (HP:0002841)1.91351215
116Gingival bleeding (HP:0000225)1.90641211
117Aplasia/Hypoplasia of the spleen (HP:0010451)1.88535064
118Hypochromic microcytic anemia (HP:0004840)1.86750806
119Keratoconjunctivitis sicca (HP:0001097)1.85463595
120Abnormality of the fingertips (HP:0001211)1.85142044
121Recurrent cutaneous fungal infections (HP:0011370)1.83130433
122Chronic mucocutaneous candidiasis (HP:0002728)1.83130433
123Abnormality of T cell number (HP:0011839)1.83125911
124Leukocytosis (HP:0001974)1.82981070
125Gastrointestinal infarctions (HP:0005244)1.82614222
126Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.81241154
127Myokymia (HP:0002411)1.80644407
128Prolonged bleeding time (HP:0003010)1.80093150
129Chronic sinusitis (HP:0011109)1.79386912
130Supranuclear gaze palsy (HP:0000605)1.79088800
131Abnormality of midbrain morphology (HP:0002418)1.78759424
132Molar tooth sign on MRI (HP:0002419)1.78759424
133Dysmetria (HP:0001310)1.78736185
134Agitation (HP:0000713)1.78594267
135Esotropia (HP:0000565)1.77970936
136Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.77576044
137Duplicated collecting system (HP:0000081)1.76752440
138Impaired smooth pursuit (HP:0007772)1.76122196
139Acute myeloid leukemia (HP:0004808)1.75875019
140Amblyopia (HP:0000646)1.75804961
141Increased CSF protein (HP:0002922)1.75696822
142Thyroiditis (HP:0100646)1.75408767
143Impaired social interactions (HP:0000735)1.74705122
144Abnormal social behavior (HP:0012433)1.74705122
145Pancreatic cysts (HP:0001737)1.74168114
146Methylmalonic aciduria (HP:0012120)1.73934565
147Abnormality of the vitamin B12 metabolism (HP:0004341)1.73726811
148Male infertility (HP:0003251)1.73513249
149Decreased central vision (HP:0007663)1.73155395
150Hyperphosphatemia (HP:0002905)1.73131742
151Abnormality of cells of the lymphoid lineage (HP:0012140)1.72382138
152Vacuolated lymphocytes (HP:0001922)1.72286763
153Congenital stationary night blindness (HP:0007642)1.72050070
154Arterial thrombosis (HP:0004420)1.71974833
155Pulmonary infiltrates (HP:0002113)1.71350803
156Obstructive sleep apnea (HP:0002870)1.71283294
157Neutropenia (HP:0001875)1.71044294
158Agnosia (HP:0010524)1.70389716
159Abnormality of male internal genitalia (HP:0000022)1.69881728
160Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69784640
161Flat occiput (HP:0005469)1.69720703
162Goiter (HP:0000853)1.68979802
163Abnormality of macrophages (HP:0004311)1.68891808
164Meningitis (HP:0001287)1.68675036
165Chronic diarrhea (HP:0002028)1.68394334
166Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68194364
167Severe combined immunodeficiency (HP:0004430)1.68016931
168Keratoconjunctivitis (HP:0001096)1.67535437
169Pancreatic fibrosis (HP:0100732)1.67030161
170Degeneration of the lateral corticospinal tracts (HP:0002314)1.66651125
171Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66651125
172Hemiparesis (HP:0001269)1.65534390
173Petechiae (HP:0000967)1.62361562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.14689699
2NTRK33.23991293
3EPHA43.07674623
4MAP3K92.63538337
5MAP3K122.61081977
6BMPR22.59410704
7MAP3K132.45097384
8MAP2K72.32560416
9TNIK2.28422839
10IRAK22.25433466
11ARAF2.20249509
12STK242.18767900
13TXK2.13607915
14KSR22.09358167
15FES1.91688545
16MKNK21.86455446
17TAOK31.84625149
18MAP3K41.80236958
19MAP3K61.79137251
20RAF11.78108946
21MAP4K21.76544724
22PLK21.69774032
23MAP3K21.69492176
24NUAK11.62527933
25MAP3K141.61966026
26EIF2AK31.57948033
27FRK1.56761485
28MAP2K41.55470467
29BLK1.53124183
30PNCK1.53080463
31AKT31.52080551
32DAPK21.44971060
33BTK1.44297825
34TLK11.43802122
35GRK51.43510268
36CSK1.36043596
37CASK1.35866980
38IRAK11.33367010
39KSR11.26594969
40MOS1.20193671
41TNK21.19949488
42MST41.15499308
43NLK1.15225637
44PRKD21.15025521
45TAF11.14610209
46WNK11.12004828
47CDK31.07711526
48ADRBK21.03391126
49STK161.02317317
50CSF1R1.02011721
51GRK70.99904939
52FGR0.99405862
53GRK10.94620623
54BMPR1B0.93968087
55WNK30.90084391
56MAP3K10.89668944
57PINK10.86303484
58PIM10.85478192
59SYK0.85240705
60MAPK150.84172223
61MAPKAPK50.81668556
62SGK20.78944998
63TBK10.78576596
64PAK60.78111192
65PRKCQ0.77457312
66CHUK0.77118456
67MAP2K30.76563228
68PRPF4B0.76140561
69MARK30.74996951
70STK110.74194292
71TEC0.73609785
72CAMKK20.73302705
73MINK10.72675435
74MAP2K20.72003815
75YES10.71221442
76MELK0.70710988
77NEK60.70536155
78BRSK20.70078596
79CDK80.69733702
80MAP4K10.69323187
81NEK90.69308025
82SGK4940.69304592
83SGK2230.69304592
84DAPK10.68615592
85LATS20.68447055
86PDK10.67331544
87PLK30.66388400
88GRK60.66027127
89SGK10.64679837
90RPS6KB10.64081137
91BRD40.63962629
92IRAK30.62787537
93JAK20.62193898
94ERBB30.61444093
95PAK30.61031323
96SIK20.59738741
97CDK50.59222249
98MUSK0.58256095
99DYRK1A0.57784647
100CAMK2A0.57131137
101STK30.56400117
102IKBKB0.56398485
103ACVR1B0.56017066
104IKBKE0.55628073
105STK390.55510074
106MAP3K50.55306481
107ALK0.54813299
108OXSR10.54266287
109TYRO30.53703586
110DMPK0.53486064
111STK38L0.53414963
112MAP2K60.52561325
113MAPK70.52529044
114ZAP700.51402025
115HIPK20.50719092
116NTRK20.50655816
117TRPM70.50118153
118LCK0.49741318
119MAPK130.49610904
120SGK30.49364035
121FGFR30.48666638
122CAMK2B0.47991052
123IRAK40.47370589
124JAK30.47332551
125STK100.47074152
126PRKCH0.47067826
127CDK90.46323927
128VRK10.45707677
129HCK0.45326682
130RET0.43685587
131WNK40.42354311
132CAMKK10.41923827
133WEE10.41629841
134JAK10.41397595
135PDPK10.41020661
136MAPK110.41004090
137CSNK1G20.40954008
138PRKCG0.40686012
139IGF1R0.40252601
140MAPK100.38918372
141MKNK10.38892005
142TYK20.38601737
143BRAF0.37905623
144LYN0.37729244
145FGFR20.37032887
146KIT0.36832637
147STK380.36331957
148ITK0.35677870
149ABL20.34621669

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.97419860
2Primary immunodeficiency_Homo sapiens_hsa053402.71277705
3Long-term potentiation_Homo sapiens_hsa047202.44956663
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.27561907
5Amphetamine addiction_Homo sapiens_hsa050312.15995846
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.90016336
7Long-term depression_Homo sapiens_hsa047301.71269706
8Synaptic vesicle cycle_Homo sapiens_hsa047211.71019192
9Glutamatergic synapse_Homo sapiens_hsa047241.70359703
10Collecting duct acid secretion_Homo sapiens_hsa049661.67736675
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.63969159
12Rheumatoid arthritis_Homo sapiens_hsa053231.61380445
13Morphine addiction_Homo sapiens_hsa050321.60888881
14Type I diabetes mellitus_Homo sapiens_hsa049401.56378763
15GABAergic synapse_Homo sapiens_hsa047271.51777603
16Serotonergic synapse_Homo sapiens_hsa047261.45966828
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.43148414
18Dorso-ventral axis formation_Homo sapiens_hsa043201.41548319
19Taste transduction_Homo sapiens_hsa047421.39677501
20Vitamin B6 metabolism_Homo sapiens_hsa007501.35921831
21Salivary secretion_Homo sapiens_hsa049701.35595614
22Circadian entrainment_Homo sapiens_hsa047131.35131493
23Cocaine addiction_Homo sapiens_hsa050301.34058666
24Olfactory transduction_Homo sapiens_hsa047401.33197932
25Renin secretion_Homo sapiens_hsa049241.33108565
26Staphylococcus aureus infection_Homo sapiens_hsa051501.31928775
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29948710
28Dopaminergic synapse_Homo sapiens_hsa047281.28253083
29Osteoclast differentiation_Homo sapiens_hsa043801.24208019
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24151608
31GnRH signaling pathway_Homo sapiens_hsa049121.21788434
32Insulin secretion_Homo sapiens_hsa049111.17782815
33SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16391661
34T cell receptor signaling pathway_Homo sapiens_hsa046601.15823968
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12715852
36Herpes simplex infection_Homo sapiens_hsa051681.11136654
37Antigen processing and presentation_Homo sapiens_hsa046121.10737210
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10728763
39Graft-versus-host disease_Homo sapiens_hsa053321.09405447
40Tuberculosis_Homo sapiens_hsa051521.09377553
41Leishmaniasis_Homo sapiens_hsa051401.07084976
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.06813892
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06705131
44Cholinergic synapse_Homo sapiens_hsa047251.06155561
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05553826
46B cell receptor signaling pathway_Homo sapiens_hsa046621.05484373
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.05469737
48Oxytocin signaling pathway_Homo sapiens_hsa049211.05136817
49Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03227371
50Estrogen signaling pathway_Homo sapiens_hsa049151.02846776
51Circadian rhythm_Homo sapiens_hsa047101.02783179
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.02748461
53Choline metabolism in cancer_Homo sapiens_hsa052310.99824201
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99448045
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98571574
56MAPK signaling pathway_Homo sapiens_hsa040100.97118205
57Allograft rejection_Homo sapiens_hsa053300.95296392
58Calcium signaling pathway_Homo sapiens_hsa040200.93791656
59cAMP signaling pathway_Homo sapiens_hsa040240.93761484
60Sphingolipid metabolism_Homo sapiens_hsa006000.92019917
61Inositol phosphate metabolism_Homo sapiens_hsa005620.91389852
62Oocyte meiosis_Homo sapiens_hsa041140.91347163
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89400061
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86116153
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85100161
66Melanoma_Homo sapiens_hsa052180.84633906
67Type II diabetes mellitus_Homo sapiens_hsa049300.83807150
68Gastric acid secretion_Homo sapiens_hsa049710.82840518
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82803114
70Asthma_Homo sapiens_hsa053100.81488687
71Chemokine signaling pathway_Homo sapiens_hsa040620.80962913
72Renal cell carcinoma_Homo sapiens_hsa052110.80953485
73RNA degradation_Homo sapiens_hsa030180.80922676
74Autoimmune thyroid disease_Homo sapiens_hsa053200.80704495
75Non-small cell lung cancer_Homo sapiens_hsa052230.80560583
76Vibrio cholerae infection_Homo sapiens_hsa051100.78632849
77Prolactin signaling pathway_Homo sapiens_hsa049170.78586256
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.78261064
79TNF signaling pathway_Homo sapiens_hsa046680.77387004
80Hepatitis B_Homo sapiens_hsa051610.75958981
81Hepatitis C_Homo sapiens_hsa051600.75514033
82Acute myeloid leukemia_Homo sapiens_hsa052210.75231847
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75149376
84Glioma_Homo sapiens_hsa052140.73477753
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72706066
86Phototransduction_Homo sapiens_hsa047440.72601311
87RNA polymerase_Homo sapiens_hsa030200.72175175
88FoxO signaling pathway_Homo sapiens_hsa040680.71790023
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70839969
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70175580
91African trypanosomiasis_Homo sapiens_hsa051430.69674926
92ErbB signaling pathway_Homo sapiens_hsa040120.68250858
93Systemic lupus erythematosus_Homo sapiens_hsa053220.67700754
94Thyroid hormone synthesis_Homo sapiens_hsa049180.67194505
95Gap junction_Homo sapiens_hsa045400.67180520
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67130365
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.66819371
98Prion diseases_Homo sapiens_hsa050200.66656608
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.65666294
100Protein export_Homo sapiens_hsa030600.65600348
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65373120
102Salmonella infection_Homo sapiens_hsa051320.65303928
103Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64869622
104Toxoplasmosis_Homo sapiens_hsa051450.64556113
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.64485746
106Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.63829917
107Phagosome_Homo sapiens_hsa041450.63728871
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63435981
109Measles_Homo sapiens_hsa051620.63430988
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62382216
111Basal transcription factors_Homo sapiens_hsa030220.62237415
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60847149
113Folate biosynthesis_Homo sapiens_hsa007900.60712794
114VEGF signaling pathway_Homo sapiens_hsa043700.59524688
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58183811
116Hematopoietic cell lineage_Homo sapiens_hsa046400.56846024
117Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56373801
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.55829554
119Insulin resistance_Homo sapiens_hsa049310.55775257
120Influenza A_Homo sapiens_hsa051640.55739169
121Platelet activation_Homo sapiens_hsa046110.54395125
122Regulation of autophagy_Homo sapiens_hsa041400.54208556
123Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53766740
124Prostate cancer_Homo sapiens_hsa052150.53641380
125mTOR signaling pathway_Homo sapiens_hsa041500.51827490
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.50964717
127Jak-STAT signaling pathway_Homo sapiens_hsa046300.50458721
128Viral myocarditis_Homo sapiens_hsa054160.49994926
129Endometrial cancer_Homo sapiens_hsa052130.49668166
130Vitamin digestion and absorption_Homo sapiens_hsa049770.47978724
131Malaria_Homo sapiens_hsa051440.45799085
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45731145
133Ether lipid metabolism_Homo sapiens_hsa005650.44693576
134ABC transporters_Homo sapiens_hsa020100.44492642
135Lysosome_Homo sapiens_hsa041420.44292566
136Viral carcinogenesis_Homo sapiens_hsa052030.43328802
137Ras signaling pathway_Homo sapiens_hsa040140.42883456
138Other glycan degradation_Homo sapiens_hsa005110.42389443
139Legionellosis_Homo sapiens_hsa051340.42303015

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