FBXO34

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm capacitation (GO:0048240)5.48693941
2mitotic metaphase plate congression (GO:0007080)5.46968083
3piRNA metabolic process (GO:0034587)5.01268111
4attachment of spindle microtubules to kinetochore (GO:0008608)4.51572216
5mitotic sister chromatid segregation (GO:0000070)4.49186299
6protein localization to kinetochore (GO:0034501)4.48992407
7metaphase plate congression (GO:0051310)4.43788306
8spermatid nucleus differentiation (GO:0007289)4.37649268
9regulation of meiosis (GO:0040020)4.28726920
10protein targeting to Golgi (GO:0000042)4.27748987
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.27538317
12mitotic chromosome condensation (GO:0007076)4.18276058
13retrograde transport, vesicle recycling within Golgi (GO:0000301)4.16969387
14protein localization to chromosome, centromeric region (GO:0071459)4.15916748
15establishment of chromosome localization (GO:0051303)4.11740938
16chromosome condensation (GO:0030261)4.08410459
17regulation of meiosis I (GO:0060631)4.05615582
18female gamete generation (GO:0007292)4.04885027
19regulation of female gonad development (GO:2000194)4.03425363
20oocyte maturation (GO:0001556)4.03069734
21synaptic vesicle docking involved in exocytosis (GO:0016081)3.96714721
22negative regulation of meiosis (GO:0045835)3.95832060
23establishment of protein localization to Golgi (GO:0072600)3.90918983
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.90472214
25DNA packaging (GO:0006323)3.88388950
26antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.82925628
27acrosome reaction (GO:0007340)3.75583229
28sister chromatid segregation (GO:0000819)3.75484282
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.75005437
30regulation of exit from mitosis (GO:0007096)3.68781675
31positive regulation of chromosome segregation (GO:0051984)3.67870078
32regulation of centriole replication (GO:0046599)3.66922822
33nuclear pore complex assembly (GO:0051292)3.65864264
34regulation of DNA methylation (GO:0044030)3.62210023
35negative regulation of inclusion body assembly (GO:0090084)3.61050985
36histone H3-K9 demethylation (GO:0033169)3.60848239
37nucleus organization (GO:0006997)3.59588816
38meiotic cell cycle (GO:0051321)3.56222960
39vesicle transport along microtubule (GO:0047496)3.49206627
40glutamate secretion (GO:0014047)3.48817265
41macroautophagy (GO:0016236)3.48542632
42microtubule depolymerization (GO:0007019)3.47723793
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.45411868
44synaptic vesicle exocytosis (GO:0016079)3.43522005
45mitotic nuclear envelope disassembly (GO:0007077)3.41395897
46DNA replication checkpoint (GO:0000076)3.40340227
47negative regulation of meiotic cell cycle (GO:0051447)3.39893475
48microtubule polymerization or depolymerization (GO:0031109)3.38959110
49male meiosis (GO:0007140)3.38379142
50nuclear envelope disassembly (GO:0051081)3.36361357
51membrane disassembly (GO:0030397)3.36361357
52protein K6-linked ubiquitination (GO:0085020)3.33778823
53regulation of meiotic cell cycle (GO:0051445)3.32014819
54protein localization to chromosome (GO:0034502)3.31637580
55hypotonic response (GO:0006971)3.30855866
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.30102239
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30102239
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30102239
59regulation of NFAT protein import into nucleus (GO:0051532)3.28680421
60positive regulation of synapse maturation (GO:0090129)3.28357795
61regulation of spindle organization (GO:0090224)3.23606314
62erythrocyte development (GO:0048821)3.22198296
63sperm motility (GO:0030317)3.20586754
64synaptonemal complex assembly (GO:0007130)3.20232272
65histone exchange (GO:0043486)3.19991382
66embryonic process involved in female pregnancy (GO:0060136)3.16860430
67histone H2A monoubiquitination (GO:0035518)3.16736199
68regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14793737
69chromosome segregation (GO:0007059)3.13412911
70monoubiquitinated protein deubiquitination (GO:0035520)3.12936743
71regulation of synaptic vesicle transport (GO:1902803)3.11879521
72multicellular organism reproduction (GO:0032504)3.11718022
73inner cell mass cell proliferation (GO:0001833)3.11462013
74regulation of chromosome segregation (GO:0051983)3.09623436
75histone H3-K36 demethylation (GO:0070544)3.09571134
76protoporphyrinogen IX metabolic process (GO:0046501)3.09044368
77regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.08984253
78regulation of RNA export from nucleus (GO:0046831)3.08409042
79CENP-A containing nucleosome assembly (GO:0034080)3.08186217
80COPII vesicle coating (GO:0048208)3.06352496
81phosphatidylethanolamine biosynthetic process (GO:0006646)3.05871791
82chromatin remodeling at centromere (GO:0031055)3.04732131
83production of molecular mediator involved in inflammatory response (GO:0002532)3.04543883
84negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.04230534
85meiotic chromosome segregation (GO:0045132)3.02978631
86microtubule severing (GO:0051013)3.02171424
87synaptonemal complex organization (GO:0070193)3.01414521
88DNA methylation involved in gamete generation (GO:0043046)3.00811252
89fusion of sperm to egg plasma membrane (GO:0007342)3.00080602
90regulation of sister chromatid cohesion (GO:0007063)2.99339386
91vocalization behavior (GO:0071625)2.98916959
92DNA replication-independent nucleosome organization (GO:0034724)2.98842211
93DNA replication-independent nucleosome assembly (GO:0006336)2.98842211
94negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.96799836
95Golgi to endosome transport (GO:0006895)2.95683975
96phosphatidylethanolamine metabolic process (GO:0046337)2.95096871
97regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93367030
98regulation of nucleobase-containing compound transport (GO:0032239)2.91728882
99pore complex assembly (GO:0046931)2.91290221
100histone H2A ubiquitination (GO:0033522)2.91121562
101male meiosis I (GO:0007141)2.90766939
102regulation of mitotic spindle organization (GO:0060236)2.89016373
103meiotic cell cycle process (GO:1903046)2.87469228
104regulation of centrosome cycle (GO:0046605)2.87421713
105gene silencing by RNA (GO:0031047)2.86101589
106regulation of synaptic vesicle exocytosis (GO:2000300)2.85657967
107regulation of glutamate receptor signaling pathway (GO:1900449)2.85564959
108nerve growth factor signaling pathway (GO:0038180)2.84518515
109synaptic vesicle endocytosis (GO:0048488)2.83858844
110negative T cell selection (GO:0043383)2.82389105
111reproduction (GO:0000003)2.80806300
112negative regulation of hormone metabolic process (GO:0032351)2.80145618
113negative regulation of hormone biosynthetic process (GO:0032353)2.80145618
114actin filament capping (GO:0051693)2.79512843
115positive regulation of fibroblast migration (GO:0010763)2.79465904
116meiosis I (GO:0007127)2.77690755
117positive regulation of humoral immune response (GO:0002922)2.77449642
118synaptic vesicle maturation (GO:0016188)2.76482251
119spindle checkpoint (GO:0031577)2.76232718
120chromatin assembly or disassembly (GO:0006333)2.76220742
121meiotic nuclear division (GO:0007126)2.75856568
122glycine transport (GO:0015816)2.74959152
123nuclear pore organization (GO:0006999)2.73814098
124oogenesis (GO:0048477)2.73061106
125response to insecticide (GO:0017085)2.73051562
126response to histamine (GO:0034776)2.71938550
127nuclear envelope organization (GO:0006998)2.71543092
128centriole assembly (GO:0098534)2.70349542
129rRNA methylation (GO:0031167)2.68406636
130positive T cell selection (GO:0043368)2.64868441
131oocyte development (GO:0048599)2.64252597
132retinoic acid receptor signaling pathway (GO:0048384)2.63796671
133regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63391317
134motile cilium assembly (GO:0044458)2.63038163
135regulation of translational termination (GO:0006449)2.62524591
136coronary vasculature morphogenesis (GO:0060977)2.61046274
137positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.60409645
138protein localization to synapse (GO:0035418)2.59062325
139glutamate receptor signaling pathway (GO:0007215)2.58743467
140regulation of clathrin-mediated endocytosis (GO:2000369)2.58243656
141histone demethylation (GO:0016577)2.57421055
142histone lysine demethylation (GO:0070076)2.56744465
143spermatid development (GO:0007286)2.55744653
144RNA destabilization (GO:0050779)2.54714773
145myeloid cell development (GO:0061515)2.54513346
146synaptic transmission, glutamatergic (GO:0035249)2.54510446
147locomotory exploration behavior (GO:0035641)2.54372659
148ionotropic glutamate receptor signaling pathway (GO:0035235)2.52616668
149sexual reproduction (GO:0019953)2.52562301
150regulation of mitotic metaphase/anaphase transition (GO:0030071)2.52421532
151negative regulation of histone methylation (GO:0031061)2.52052935
152peptidyl-threonine dephosphorylation (GO:0035970)2.51797957
153vitamin transmembrane transport (GO:0035461)2.51519364
154cytoskeletal anchoring at plasma membrane (GO:0007016)2.50752034
155definitive hemopoiesis (GO:0060216)2.49315326
156centriole replication (GO:0007099)2.47485140
157microtubule nucleation (GO:0007020)2.43897792
158protein localization to Golgi apparatus (GO:0034067)2.43772052
159protein kinase C signaling (GO:0070528)2.43650638
160regulation of interferon-beta biosynthetic process (GO:0045357)2.42621754
161regulation of interleukin-13 production (GO:0032656)2.41310106
162regulation of acrosome reaction (GO:0060046)2.41003879
163protein demethylation (GO:0006482)2.40626818
164protein dealkylation (GO:0008214)2.40626818
165negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39468293
166peptidyl-lysine trimethylation (GO:0018023)2.36941895
167regulation of skeletal muscle cell differentiation (GO:2001014)2.36863379
168protein depolymerization (GO:0051261)2.36580974
169negative regulation of actin filament depolymerization (GO:0030835)2.33485584
170sperm-egg recognition (GO:0035036)2.33104326
171calcium ion-dependent exocytosis (GO:0017156)2.31983809
172binding of sperm to zona pellucida (GO:0007339)2.30605719
173pyrimidine-containing compound transmembrane transport (GO:0072531)2.30568253
174spliceosomal tri-snRNP complex assembly (GO:0000244)2.30120744
175positive regulation of Rab GTPase activity (GO:0032851)2.27232534
176regulation of Rab GTPase activity (GO:0032313)2.27232534
177cell wall macromolecule metabolic process (GO:0044036)2.26029109
178skeletal muscle adaptation (GO:0043501)2.24427165
179axonemal dynein complex assembly (GO:0070286)2.23526818
180negative regulation of NF-kappaB import into nucleus (GO:0042347)2.23035054
181response to nerve growth factor (GO:1990089)2.20707948
182cellular response to nerve growth factor stimulus (GO:1990090)2.20707948
183cellular response to fluid shear stress (GO:0071498)2.20682924
184endoplasmic reticulum organization (GO:0007029)2.18946102
185organelle transport along microtubule (GO:0072384)2.18183389
186intra-Golgi vesicle-mediated transport (GO:0006891)2.18142728
187regulation of cilium movement (GO:0003352)2.17483639
188fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.17181592
189negative regulation of T cell mediated immunity (GO:0002710)2.16826741
190sialylation (GO:0097503)2.16437730
191muscle organ morphogenesis (GO:0048644)2.15648462
192receptor recycling (GO:0001881)2.14545351

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.01061219
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.90976680
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.54515869
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.70370744
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.63575625
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.45774204
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24853970
8STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19438950
9EZH2_22144423_ChIP-Seq_EOC_Human3.13481634
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.04814786
11AR_21909140_ChIP-Seq_LNCAP_Human2.87772045
12RUNX_20019798_ChIP-Seq_JUKART_Human2.78780447
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.66445028
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.44893361
15ESR1_20079471_ChIP-ChIP_T-47D_Human2.27847326
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.18011011
17ZNF217_24962896_ChIP-Seq_MCF-7_Human2.11775654
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11349031
19GATA2_21666600_ChIP-Seq_HMVEC_Human2.04146059
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.03512000
21RARB_27405468_Chip-Seq_BRAIN_Mouse2.02964749
22* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.02606221
23* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00763533
24FOXO3_23340844_ChIP-Seq_DLD1_Human1.98346790
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.96103428
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.94274320
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91670828
28* MYB_26560356_Chip-Seq_TH2_Human1.89182830
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87034633
30REST_21632747_ChIP-Seq_MESCs_Mouse1.84122896
31GATA2_19941826_ChIP-Seq_K562_Human1.83100461
32EGR1_19374776_ChIP-ChIP_THP-1_Human1.82385833
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82096554
34RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79318370
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76676643
36SOX2_27498859_Chip-Seq_STOMACH_Mouse1.71777909
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.67449784
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66950218
39* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.65848523
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.64147428
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.63566784
42ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59260149
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.57859671
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56425428
45GATA1_26923725_Chip-Seq_HPCs_Mouse1.55907384
46GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55460120
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.55068255
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.54507229
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.54507229
50FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.54261068
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.52589589
52TCF4_18268006_ChIP-ChIP_LS174T_Human1.51876144
53REST_18959480_ChIP-ChIP_MESCs_Mouse1.50234920
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48706952
55AHR_22903824_ChIP-Seq_MCF-7_Human1.45990146
56FOXM1_26456572_ChIP-Seq_MCF-7_Human1.45838486
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.45601522
58KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44653487
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.43967007
60* GATA6_25053715_ChIP-Seq_YYC3_Human1.40592109
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40314911
62SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.37866209
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37780765
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37622847
65TP63_23658742_ChIP-Seq_EP156T_Human1.37563095
66ZNF263_19887448_ChIP-Seq_K562_Human1.37075411
67EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36049482
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35017298
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34815782
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34551416
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.34317242
72MYC_22102868_ChIP-Seq_BL_Human1.33938447
73CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.33259607
74IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29566611
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28889863
76FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.24165121
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23941171
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.23875195
79* MYB_26560356_Chip-Seq_TH1_Human1.23633339
80FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22757804
81* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.22222786
82GATA3_27048872_Chip-Seq_THYMUS_Human1.21743267
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20123208
84* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19078399
85SALL4_22934838_ChIP-ChIP_CD34+_Human1.18456916
86CBP_20019798_ChIP-Seq_JUKART_Human1.18137028
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18137028
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17425747
89* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16604216
90MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.15119945
91NANOG_18555785_ChIP-Seq_MESCs_Mouse1.14153884
92* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14113519
93ER_23166858_ChIP-Seq_MCF-7_Human1.13835328
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.13502636
95GATA3_26560356_Chip-Seq_TH2_Human1.11639381
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10745754
97CJUN_26792858_Chip-Seq_BT549_Human1.09562691
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09455324
99RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08484553
100RUNX1_27514584_Chip-Seq_MCF-7_Human1.07923238
101FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.07873970
102ELK4_26923725_Chip-Seq_MESODERM_Mouse1.07272338
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.06081073
104GABP_19822575_ChIP-Seq_HepG2_Human1.05986562
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04966277
106EP300_21415370_ChIP-Seq_HL-1_Mouse1.04446032
107PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03161816
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03060913
109VDR_24787735_ChIP-Seq_THP-1_Human1.03045732
110* MAF_26560356_Chip-Seq_TH1_Human1.02837177
111IRF8_27001747_Chip-Seq_BMDM_Mouse1.02349162
112KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.02312261
113FLI1_27457419_Chip-Seq_LIVER_Mouse1.01472167
114KLF5_25053715_ChIP-Seq_YYC3_Human1.01169489
115FOXA2_19822575_ChIP-Seq_HepG2_Human1.00770318
116FUS_26573619_Chip-Seq_HEK293_Human1.00703595
117SCL_19346495_ChIP-Seq_HPC-7_Human1.00291491
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.99686730
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99196396
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99058724
121CDX2_22108803_ChIP-Seq_LS180_Human0.98973102
122RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97005458
123* SPI1_23127762_ChIP-Seq_K562_Human0.96931614
124MYC_18940864_ChIP-ChIP_HL60_Human0.96207077
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95915470
126TET1_21490601_ChIP-Seq_MESCs_Mouse0.95677130
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.95535348
128CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94676235
129PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94561248
130* GATA1_19941827_ChIP-Seq_MEL_Mouse0.94160149
131TCF7_22412390_ChIP-Seq_EML_Mouse0.92580495
132KDM5A_27292631_Chip-Seq_BREAST_Human0.92550616
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92146500
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.92099961
135IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91292142
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90788439
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89959835
138PRDM14_20953172_ChIP-Seq_ESCs_Human0.89611953
139AR_25329375_ChIP-Seq_VCAP_Human0.89559476
140SMAD4_21741376_ChIP-Seq_EPCs_Human0.89550925
141SOX9_24532713_ChIP-Seq_HFSC_Mouse0.89117439
142SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88378912
143KAP1_27257070_Chip-Seq_ESCs_Mouse0.87926416
144GATA1_19941826_ChIP-Seq_K562_Human0.87869368
145* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87462067
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87055575
147SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86828929
148SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86101298
149VDR_22108803_ChIP-Seq_LS180_Human0.84953482
150TP53_22573176_ChIP-Seq_HFKS_Human0.84722921
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.84518231
152TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83294169
153TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.82521271
154SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80706496
155CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.80195484
156ETS1_20019798_ChIP-Seq_JURKAT_Human0.79117061
157STAT3_23295773_ChIP-Seq_U87_Human0.78979093
158NELFA_20434984_ChIP-Seq_ESCs_Mouse0.78801308
159MYB_21317192_ChIP-Seq_ERMYB_Mouse0.77127830
160TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74469448
161GATA3_26560356_Chip-Seq_TH1_Human0.72928883
162FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.72656660
163* ATF3_27146783_Chip-Seq_COLON_Human0.72079831
164STAT1_17558387_ChIP-Seq_HELA_Human0.69134459
165POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.68272266
166DPY_21335234_ChIP-Seq_ESCs_Mouse0.67805182
167GBX2_23144817_ChIP-Seq_PC3_Human0.67463989
168NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.67390761
169* SMAD4_21799915_ChIP-Seq_A2780_Human0.66879064
170OCT4_19829295_ChIP-Seq_ESCs_Human0.66215874
171FOXH1_21741376_ChIP-Seq_EPCs_Human0.66172208
172GATA1_22025678_ChIP-Seq_K562_Human0.66038476
173ETS1_22383799_ChIP-Seq_G1ME_Mouse0.65565453
174GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.64856004
175JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.63289253
176SMRT_27268052_Chip-Seq_Bcells_Human0.62889114
177THAP11_20581084_ChIP-Seq_MESCs_Mouse0.62836639
178NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.62509808
179P53_22127205_ChIP-Seq_FIBROBLAST_Human0.61972706

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.95460245
2MP0003693_abnormal_embryo_hatching3.84331465
3MP0008877_abnormal_DNA_methylation3.73065899
4MP0003300_gastrointestinal_ulcer3.22901449
5MP0003718_maternal_effect3.14086221
6MP0003880_abnormal_central_pattern3.12548509
7MP0003111_abnormal_nucleus_morphology3.11057932
8MP0010094_abnormal_chromosome_stability2.75706375
9MP0003635_abnormal_synaptic_transmissio2.71724444
10MP0010234_abnormal_vibrissa_follicle2.62033329
11MP0002138_abnormal_hepatobiliary_system2.61057172
12MP0003656_abnormal_erythrocyte_physiolo2.54256928
13MP0002132_abnormal_respiratory_system2.35608227
14MP0003763_abnormal_thymus_physiology2.33539481
15MP0004270_analgesia2.33134871
16MP0002063_abnormal_learning/memory/cond2.25737665
17MP0003077_abnormal_cell_cycle2.22655413
18MP0002653_abnormal_ependyma_morphology2.21181912
19MP0003191_abnormal_cellular_cholesterol2.17954602
20MP0004957_abnormal_blastocyst_morpholog2.12545729
21MP0001929_abnormal_gametogenesis2.11418726
22MP0010352_gastrointestinal_tract_polyps2.09091192
23MP0003724_increased_susceptibility_to2.07478922
24MP0003787_abnormal_imprinting2.04633617
25MP0003329_amyloid_beta_deposits2.00952283
26MP0009745_abnormal_behavioral_response1.96857339
27MP0003879_abnormal_hair_cell1.96540052
28MP0003123_paternal_imprinting1.94309857
29MP0004043_abnormal_pH_regulation1.90510035
30MP0003221_abnormal_cardiomyocyte_apopto1.88356238
31MP0000569_abnormal_digit_pigmentation1.87707530
32MP0000465_gastrointestinal_hemorrhage1.85552250
33MP0005451_abnormal_body_composition1.84244139
34MP0002736_abnormal_nociception_after1.80461732
35MP0008004_abnormal_stomach_pH1.79112901
36MP0010307_abnormal_tumor_latency1.78543135
37MP0009780_abnormal_chondrocyte_physiolo1.76049515
38MP0001968_abnormal_touch/_nociception1.75287371
39MP0002572_abnormal_emotion/affect_behav1.67672816
40MP0001501_abnormal_sleep_pattern1.67272227
41MP0002064_seizures1.65737041
42MP0003699_abnormal_female_reproductive1.64120740
43MP0005083_abnormal_biliary_tract1.63702327
44MP0005310_abnormal_salivary_gland1.61978318
45MP0002210_abnormal_sex_determination1.56206168
46MP0000653_abnormal_sex_gland1.55649364
47MP0004264_abnormal_extraembryonic_tissu1.53287881
48MP0003828_pulmonary_edema1.52295791
49MP0004484_altered_response_of1.49548669
50MP0004233_abnormal_muscle_weight1.49451091
51MP0004947_skin_inflammation1.48882767
52MP0003646_muscle_fatigue1.47417980
53MP0002161_abnormal_fertility/fecundity1.46848224
54MP0008057_abnormal_DNA_replication1.45731523
55MP0001529_abnormal_vocalization1.45223279
56MP0009046_muscle_twitch1.43633971
57MP0010678_abnormal_skin_adnexa1.42135029
58MP0003698_abnormal_male_reproductive1.42134588
59MP0000604_amyloidosis1.41409652
60MP0003045_fibrosis1.40246107
61MP0001119_abnormal_female_reproductive1.39946520
62MP0002734_abnormal_mechanical_nocicepti1.38616435
63MP0004858_abnormal_nervous_system1.38584244
64MP0005410_abnormal_fertilization1.38098459
65MP0002102_abnormal_ear_morphology1.37302793
66MP0002166_altered_tumor_susceptibility1.35389832
67MP0000749_muscle_degeneration1.34458012
68MP0001440_abnormal_grooming_behavior1.33870712
69MP0001730_embryonic_growth_arrest1.33318758
70MP0008260_abnormal_autophagy1.32795387
71MP0008058_abnormal_DNA_repair1.26758047
72MP0004510_myositis1.26586340
73MP0003436_decreased_susceptibility_to1.23038406
74MP0000350_abnormal_cell_proliferation1.22032751
75MP0008995_early_reproductive_senescence1.20520485
76MP0000747_muscle_weakness1.20478769
77MP0002006_tumorigenesis1.20077214
78MP0001145_abnormal_male_reproductive1.19992877
79MP0001765_abnormal_ion_homeostasis1.18287051
80MP0002332_abnormal_exercise_endurance1.18174762
81MP0008007_abnormal_cellular_replicative1.16961755
82MP0002009_preneoplasia1.16723133
83MP0006292_abnormal_olfactory_placode1.15895363
84MP0005395_other_phenotype1.15444736
85MP0004036_abnormal_muscle_relaxation1.14250210
86MP0005166_decreased_susceptibility_to1.13573933
87MP0002272_abnormal_nervous_system1.11968276
88MP0004811_abnormal_neuron_physiology1.07500140
89MP0005025_abnormal_response_to1.06796777
90MP0005397_hematopoietic_system_phenotyp1.06562157
91MP0001545_abnormal_hematopoietic_system1.06562157
92MP0009840_abnormal_foam_cell1.05032309
93MP0002735_abnormal_chemical_nociception1.04619770
94MP0005670_abnormal_white_adipose1.01689336
95MP0003075_altered_response_to1.00274336
96MP0001905_abnormal_dopamine_level0.99341059
97MP0009333_abnormal_splenocyte_physiolog0.97582284
98MP0001502_abnormal_circadian_rhythm0.96951384
99MP0003453_abnormal_keratinocyte_physiol0.96586091
100MP0008872_abnormal_physiological_respon0.95431600
101MP0002822_catalepsy0.95131616
102MP0000759_abnormal_skeletal_muscle0.94985804
103MP0009785_altered_susceptibility_to0.94492585
104MP0003121_genomic_imprinting0.93149685
105MP0002796_impaired_skin_barrier0.92923414
106MP0004130_abnormal_muscle_cell0.92875354
107MP0005621_abnormal_cell_physiology0.90974860
108MP0002419_abnormal_innate_immunity0.90053761
109MP0002398_abnormal_bone_marrow0.90010205
110MP0002452_abnormal_antigen_presenting0.89950713
111MP0003950_abnormal_plasma_membrane0.89501455
112MP0002723_abnormal_immune_serum0.87855232
113MP0001697_abnormal_embryo_size0.86799880
114MP0003091_abnormal_cell_migration0.86721969
115MP0005000_abnormal_immune_tolerance0.86312143
116MP0005360_urolithiasis0.86244558
117MP0001819_abnormal_immune_cell0.86025832
118MP0002420_abnormal_adaptive_immunity0.85825376
119MP0004087_abnormal_muscle_fiber0.85185333
120MP0010155_abnormal_intestine_physiology0.85032468
121MP0002067_abnormal_sensory_capabilities0.84805102
122MP0005165_increased_susceptibility_to0.84126331
123MP0000703_abnormal_thymus_morphology0.83440678
124MP0001970_abnormal_pain_threshold0.81952289
125MP0005666_abnormal_adipose_tissue0.81104399
126MP0003866_abnormal_defecation0.81050237
127MP0003786_premature_aging0.80252881
128MP0005384_cellular_phenotype0.79681486
129MP0004924_abnormal_behavior0.79493372
130MP0005386_behavior/neurological_phenoty0.79493372
131MP0005646_abnormal_pituitary_gland0.79483462
132MP0002733_abnormal_thermal_nociception0.78637845
133MP0001800_abnormal_humoral_immune0.78469108
134MP0001984_abnormal_olfaction0.78253161
135MP0002405_respiratory_system_inflammati0.78252651
136MP0001672_abnormal_embryogenesis/_devel0.78150610
137MP0005380_embryogenesis_phenotype0.78150610
138MP0002019_abnormal_tumor_incidence0.77792972
139MP0002909_abnormal_adrenal_gland0.77164670
140MP0001790_abnormal_immune_system0.76713514
141MP0005387_immune_system_phenotype0.76713514
142MP0004145_abnormal_muscle_electrophysio0.75270592
143MP0005076_abnormal_cell_differentiation0.74889754
144MP0001849_ear_inflammation0.74513578
145MP0002722_abnormal_immune_system0.73944063
146MP0002269_muscular_atrophy0.73643738
147MP0000716_abnormal_immune_system0.73369387
148MP0004808_abnormal_hematopoietic_stem0.71065976
149MP0003303_peritoneal_inflammation0.70382735
150MP0009764_decreased_sensitivity_to0.70023732
151MP0000490_abnormal_crypts_of0.68809808
152MP0001915_intracranial_hemorrhage0.68753793
153MP0010386_abnormal_urinary_bladder0.68605367
154MP0001873_stomach_inflammation0.68215131
155MP0002168_other_aberrant_phenotype0.67832211
156MP0003448_altered_tumor_morphology0.67448712
157MP0002877_abnormal_melanocyte_morpholog0.66616019
158MP0000681_abnormal_thyroid_gland0.66164188
159MP0002080_prenatal_lethality0.66095399
160MP0000313_abnormal_cell_death0.65848026
161MP0001486_abnormal_startle_reflex0.65630261
162MP0003631_nervous_system_phenotype0.65056664
163MP0001845_abnormal_inflammatory_respons0.64225727
164MP0005501_abnormal_skin_physiology0.64186746
165MP0004147_increased_porphyrin_level0.63195032
166MP0003632_abnormal_nervous_system0.62857118
167MP0006035_abnormal_mitochondrial_morpho0.61714702
168MP0002066_abnormal_motor_capabilities/c0.60860007
169MP0005636_abnormal_mineral_homeostasis0.60839746
170MP0000733_abnormal_muscle_development0.60606532
171MP0009115_abnormal_fat_cell0.60402369
172MP0000751_myopathy0.60082546
173MP0002086_abnormal_extraembryonic_tissu0.57489372
174MP0008874_decreased_physiological_sensi0.57379873

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.92279668
2Male infertility (HP:0003251)5.53225938
3Birth length less than 3rd percentile (HP:0003561)4.71332109
4Tubulointerstitial nephritis (HP:0001970)4.33015916
5Visual hallucinations (HP:0002367)4.10487824
6Atonic seizures (HP:0010819)3.97145942
7Hyperkalemia (HP:0002153)3.93977487
8Focal seizures (HP:0007359)3.85507951
9Abnormality of the labia minora (HP:0012880)3.70247248
10Breast hypoplasia (HP:0003187)3.62948142
11Exocrine pancreatic insufficiency (HP:0001738)3.58621831
12Febrile seizures (HP:0002373)3.50196457
13Infertility (HP:0000789)3.49460130
14Poikilocytosis (HP:0004447)3.44560329
15Epileptic encephalopathy (HP:0200134)3.44447075
16Global brain atrophy (HP:0002283)3.43195520
17Abnormality of the lower motor neuron (HP:0002366)3.36068708
18Muscle fiber inclusion bodies (HP:0100299)3.33151800
19Exercise-induced myalgia (HP:0003738)3.31356078
20Cholecystitis (HP:0001082)3.31201000
21Abnormal gallbladder physiology (HP:0012438)3.31201000
22Nemaline bodies (HP:0003798)3.28613002
23Asymmetric septal hypertrophy (HP:0001670)3.28035588
24Absence seizures (HP:0002121)3.27215784
25Impulsivity (HP:0100710)3.21645286
26Facial hemangioma (HP:0000329)3.18365903
27Generalized tonic-clonic seizures (HP:0002069)3.15996216
28Delusions (HP:0000746)3.15764513
29Dialeptic seizures (HP:0011146)3.15440384
30Myokymia (HP:0002411)3.14345606
31Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.12900121
32Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.09177091
33Premature ovarian failure (HP:0008209)3.04693137
34Patellar aplasia (HP:0006443)3.03699049
35Acanthocytosis (HP:0001927)3.01624147
36Ankle clonus (HP:0011448)2.97075321
37Rhabdomyolysis (HP:0003201)2.94512889
38Abnormality of the heme biosynthetic pathway (HP:0010472)2.86805864
39Hyperactive renin-angiotensin system (HP:0000841)2.83666062
40Aplasia/Hypoplasia of the patella (HP:0006498)2.83169806
41Abnormality of chloride homeostasis (HP:0011422)2.74931769
42Papillary thyroid carcinoma (HP:0002895)2.73305957
43Chronic bronchitis (HP:0004469)2.73030350
44Papilledema (HP:0001085)2.71557695
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.65648323
46Reticulocytosis (HP:0001923)2.63169014
47Resting tremor (HP:0002322)2.62058844
48Curly hair (HP:0002212)2.60314038
49Carpal bone hypoplasia (HP:0001498)2.58344532
50Muscle fiber splitting (HP:0003555)2.56852934
51Slow saccadic eye movements (HP:0000514)2.56740152
52Rimmed vacuoles (HP:0003805)2.54468490
53Sandal gap (HP:0001852)2.46876159
54Dysmetric saccades (HP:0000641)2.45351874
55Myoglobinuria (HP:0002913)2.41565513
56Hypochromic microcytic anemia (HP:0004840)2.40107270
57Subaortic stenosis (HP:0001682)2.37081403
58Abnormality of the left ventricular outflow tract (HP:0011103)2.37081403
59Chromsome breakage (HP:0040012)2.35837874
60Termporal pattern (HP:0011008)2.35246380
61Insidious onset (HP:0003587)2.35246380
62Agnosia (HP:0010524)2.35102637
63Impaired smooth pursuit (HP:0007772)2.32324778
64Cholelithiasis (HP:0001081)2.27526744
65Impaired vibration sensation in the lower limbs (HP:0002166)2.26310563
66Truncal obesity (HP:0001956)2.25090238
67Bundle branch block (HP:0011710)2.24905400
68Urinary bladder sphincter dysfunction (HP:0002839)2.24476464
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24223233
70Ileus (HP:0002595)2.22742104
71Breast aplasia (HP:0100783)2.22505709
72Hand muscle atrophy (HP:0009130)2.19549226
73Cone-rod dystrophy (HP:0000548)2.17918656
74Short 1st metacarpal (HP:0010034)2.16003638
75Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.16003638
76Exercise-induced muscle cramps (HP:0003710)2.15520799
77Capillary hemangiomas (HP:0005306)2.14993937
78Deep venous thrombosis (HP:0002625)2.13492059
79Mutism (HP:0002300)2.12610534
80Secondary amenorrhea (HP:0000869)2.12248091
81Optic neuritis (HP:0100653)2.11841713
82Retrobulbar optic neuritis (HP:0100654)2.11841713
83Unsteady gait (HP:0002317)2.08057978
84Distal lower limb muscle weakness (HP:0009053)2.07372694
85Menstrual irregularities (HP:0000858)2.06568004
86Spinal muscular atrophy (HP:0007269)2.06243427
87Aplasia/Hypoplasia of the breasts (HP:0010311)2.05838765
88Centrally nucleated skeletal muscle fibers (HP:0003687)2.05780161
89Oligodactyly (hands) (HP:0001180)2.04302821
90Sensorimotor neuropathy (HP:0007141)2.03618840
91Deep palmar crease (HP:0006191)2.02844979
92Nasal polyposis (HP:0100582)2.01267953
93Abnormal neuron morphology (HP:0012757)1.99050809
94Abnormality of the motor neurons (HP:0002450)1.99050809
95Status epilepticus (HP:0002133)1.98169428
96Abnormal biliary tract morphology (HP:0012440)1.98161120
97Generalized myoclonic seizures (HP:0002123)1.97139178
98Difficulty running (HP:0009046)1.96267987
99Personality changes (HP:0000751)1.95743093
100Spontaneous abortion (HP:0005268)1.95300336
101Abnormality of the 1st metacarpal (HP:0010009)1.94755889
102Abnormality of ocular smooth pursuit (HP:0000617)1.94263695
103Abnormal gallbladder morphology (HP:0012437)1.94175164
104Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.93838827
105Hyponatremia (HP:0002902)1.93013693
106Oligodactyly (HP:0012165)1.92881150
107Steatorrhea (HP:0002570)1.91889411
108Abnormality of dental color (HP:0011073)1.91733863
109Orchitis (HP:0100796)1.91729497
110Myopathic facies (HP:0002058)1.90843868
111Abnormal spermatogenesis (HP:0008669)1.90521870
112Flat acetabular roof (HP:0003180)1.90451571
113Interstitial pulmonary disease (HP:0006530)1.90397977
114Autoamputation (HP:0001218)1.90351328
115Abnormality of the proximal phalanges of the hand (HP:0009834)1.89930940
116Myositis (HP:0100614)1.89104019
117Heterotopia (HP:0002282)1.88057113
118Pulmonary fibrosis (HP:0002206)1.87857021
119EMG: myopathic abnormalities (HP:0003458)1.87127339
120Abnormality of chromosome segregation (HP:0002916)1.85903439
121Abnormality of lateral ventricle (HP:0030047)1.85430612
122Gaze-evoked nystagmus (HP:0000640)1.85220630
123Impaired vibratory sensation (HP:0002495)1.84831112
124Flattened epiphyses (HP:0003071)1.84504381
125Fetal akinesia sequence (HP:0001989)1.84442909
126Progressive sensorineural hearing impairment (HP:0000408)1.83382664
127Cafe-au-lait spot (HP:0000957)1.83074202
128Progressive cerebellar ataxia (HP:0002073)1.83074110
129Shoulder girdle muscle weakness (HP:0003547)1.81693250
130Unilateral renal agenesis (HP:0000122)1.81692560
131Lower limb hyperreflexia (HP:0002395)1.81496367
132Amblyopia (HP:0000646)1.81061201
133Prominent nose (HP:0000448)1.80280617
134Supernumerary spleens (HP:0009799)1.79614062
135Tubulointerstitial abnormality (HP:0001969)1.77874127
136Gout (HP:0001997)1.77709272
137Thyroid carcinoma (HP:0002890)1.77295100
138Glucose intolerance (HP:0000833)1.75370576
139Keratoconjunctivitis sicca (HP:0001097)1.73916727
140Frequent falls (HP:0002359)1.73701888
141Malignant hyperthermia (HP:0002047)1.73675192
142Right ventricular cardiomyopathy (HP:0011663)1.73484738
143Germ cell neoplasia (HP:0100728)1.73146582
144Erythema (HP:0010783)1.73133360
145Protruding tongue (HP:0010808)1.72828965
146Amyotrophic lateral sclerosis (HP:0007354)1.72592195
147Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72332947
148Cystic hygroma (HP:0000476)1.72148818
149Abnormality of chromosome stability (HP:0003220)1.72101335
150Fatigue (HP:0012378)1.72062533
151Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.72004247
152Genetic anticipation (HP:0003743)1.70841348
153Complete atrioventricular canal defect (HP:0001674)1.70436652
154Postural instability (HP:0002172)1.69438237
155Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.69287515
156Bradykinesia (HP:0002067)1.68939713
157Azoospermia (HP:0000027)1.68776166
158Pelvic girdle muscle weakness (HP:0003749)1.67923610
159Abnormality of potassium homeostasis (HP:0011042)1.67225813
160Distal upper limb amyotrophy (HP:0007149)1.66731974
161Upper limb amyotrophy (HP:0009129)1.66731974
162Anhidrosis (HP:0000970)1.66454687
163Poor eye contact (HP:0000817)1.66228096
164Duodenal stenosis (HP:0100867)1.64905810
165Small intestinal stenosis (HP:0012848)1.64905810
166Epileptiform EEG discharges (HP:0011182)1.64820344
167Hyperuricemia (HP:0002149)1.64819328
168Increased purine levels (HP:0004368)1.64819328
169Difficulty climbing stairs (HP:0003551)1.64775910
170Abnormality of small intestinal villus morphology (HP:0011472)1.64504552
171Villous atrophy (HP:0011473)1.64504552
172Annular pancreas (HP:0001734)1.64388174
173Volvulus (HP:0002580)1.64365050
174Long clavicles (HP:0000890)1.63188694
175Lip pit (HP:0100267)1.62845098
176Pili torti (HP:0003777)1.61993558
177Rectal prolapse (HP:0002035)1.60890624
178Bronchiectasis (HP:0002110)1.58282908
179Eczematoid dermatitis (HP:0000976)1.57584914
180Increased CSF protein (HP:0002922)1.57324444
181Urinary urgency (HP:0000012)1.57070664

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.80369893
2MAP3K93.97270139
3KSR23.67720880
4BMPR23.28414303
5MOS3.27977781
6TESK23.19457804
7ARAF3.14748707
8EPHA42.99275402
9BRAF2.67862780
10BRD42.56716665
11MAP3K132.51247217
12NTRK32.50388617
13STK242.45764224
14MST1R2.36858599
15CDC72.30954383
16RAF12.30947757
17TESK12.30272548
18TAOK12.28539063
19TAOK32.18044846
20OBSCN2.17943924
21EIF2AK12.15013950
22TTK2.11789007
23NEK62.10452130
24MAP3K42.03782842
25BUB12.03021122
26PLK41.97622310
27MAP3K61.97567474
28LATS21.95310554
29ERBB31.86891663
30DAPK21.86331205
31PRKD31.84418800
32NEK21.84237324
33KSR11.81059696
34RIPK41.78782281
35PAK61.77081454
36PRPF4B1.73794991
37DAPK11.58331633
38CCNB11.55094267
39MET1.52906225
40MAP2K71.49335936
41MAP3K121.42354929
42CDK121.37462782
43MAP2K41.37316322
44MST41.31208103
45PLK21.29206479
46MAP3K141.28809388
47EPHA21.25972106
48BCR1.24715305
49CDK81.22717954
50DMPK1.20628356
51LATS11.19116429
52PLK11.16540915
53STK391.15811014
54EEF2K1.12836637
55PIK3CG1.12648470
56NEK11.10492485
57MINK11.09557394
58NEK91.09016831
59IRAK31.08234422
60CHEK21.06301707
61BRSK11.03374307
62WEE11.00950658
63RIPK11.00315910
64PHKG10.98527358
65PHKG20.98527358
66RPS6KA40.98422770
67JAK10.97783702
68SIK30.97578609
69PTK2B0.97214504
70CAMKK10.97120836
71PLK30.96485187
72GRK50.95360597
73STK380.94561289
74MAP3K10.92191654
75ZAP700.91389456
76WNK10.90918499
77IKBKE0.90081569
78CDK90.89857740
79SIK20.88646723
80SCYL20.88456432
81PDK30.87634215
82PDK40.87634215
83MELK0.85931057
84MAP3K80.82331435
85PNCK0.81530289
86MAP3K100.80503484
87CAMK1G0.80338462
88TYRO30.79827189
89OXSR10.79535930
90ERBB40.74286819
91TBK10.73131503
92STK100.69043045
93MAP3K20.67457709
94CDK40.66901769
95AURKA0.65581437
96MAP3K50.63306673
97PDK20.61023755
98GRK60.60868428
99RET0.59629527
100MAP3K30.59583014
101PDK10.58876818
102TRIM280.58736275
103TYK20.58381545
104PIK3CA0.58085042
105CDK50.55499980
106AURKB0.55380805
107TRPM70.53659173
108MAP2K60.52369652
109PRKG20.51357595
110CDK150.51007957
111STK30.50689447
112FES0.50566115
113CDK180.49926459
114STK38L0.48750009
115CHEK10.46978391
116MUSK0.46588111
117MAP2K30.46494302
118PRKCQ0.46484708
119SGK20.46184616
120AKT30.45552557
121TTN0.44789811
122PRKAA20.44559230
123CAMKK20.43940797
124PINK10.43733987
125MAPK70.43612303
126ROCK10.42919835
127CDK11A0.41667722
128ABL20.41145356
129PRKCG0.39601247
130JAK20.39146184
131PDPK10.38359256
132DYRK1A0.38237112
133MAPK130.37559389
134CDK20.37209781
135CDK190.36641560
136NUAK10.36133881
137IKBKB0.35954996
138BRSK20.35450757
139CLK10.34987074
140MAP2K10.34019221
141CDK140.33965091
142CDK60.33857565
143TXK0.33844108
144MARK20.33812878
145ALK0.33476373
146MAP3K110.32975842
147MAPK110.32606892
148MAPK100.32504930
149NTRK20.32450384
150CAMK2A0.32279477
151MAPKAPK30.31155745
152STK110.30958530
153PRKAA10.30418587
154SGK10.30408753
155ATM0.29525378
156SGK30.28992995
157TSSK60.28978639
158PDGFRB0.28216089

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007503.68944308
2Nicotine addiction_Homo sapiens_hsa050332.94914132
3Oocyte meiosis_Homo sapiens_hsa041142.81778377
4Long-term potentiation_Homo sapiens_hsa047202.73599838
5Synaptic vesicle cycle_Homo sapiens_hsa047212.72448145
6Cell cycle_Homo sapiens_hsa041102.41380184
7Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.21555351
8Olfactory transduction_Homo sapiens_hsa047401.92846150
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91315575
10Amphetamine addiction_Homo sapiens_hsa050311.81803908
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.80402158
12Fatty acid biosynthesis_Homo sapiens_hsa000611.76912997
13Circadian rhythm_Homo sapiens_hsa047101.74489804
14GnRH signaling pathway_Homo sapiens_hsa049121.67767342
15Glutamatergic synapse_Homo sapiens_hsa047241.67242538
16Collecting duct acid secretion_Homo sapiens_hsa049661.66033568
17Acute myeloid leukemia_Homo sapiens_hsa052211.64375873
18Circadian entrainment_Homo sapiens_hsa047131.63139603
19Dorso-ventral axis formation_Homo sapiens_hsa043201.57781570
20Basal transcription factors_Homo sapiens_hsa030221.56685724
21Salivary secretion_Homo sapiens_hsa049701.55627468
22T cell receptor signaling pathway_Homo sapiens_hsa046601.53493755
23B cell receptor signaling pathway_Homo sapiens_hsa046621.50892642
24RNA degradation_Homo sapiens_hsa030181.45730974
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45345678
26Ovarian steroidogenesis_Homo sapiens_hsa049131.43853425
27Endometrial cancer_Homo sapiens_hsa052131.38684007
28RNA transport_Homo sapiens_hsa030131.38288856
29Hepatitis C_Homo sapiens_hsa051601.38112882
30Oxytocin signaling pathway_Homo sapiens_hsa049211.35959615
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35844960
32Pancreatic secretion_Homo sapiens_hsa049721.34091545
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31870008
34Morphine addiction_Homo sapiens_hsa050321.30455756
35GABAergic synapse_Homo sapiens_hsa047271.27695744
36Influenza A_Homo sapiens_hsa051641.25886214
37DNA replication_Homo sapiens_hsa030301.25194575
38Glioma_Homo sapiens_hsa052141.21488783
39Chronic myeloid leukemia_Homo sapiens_hsa052201.20161592
40Dopaminergic synapse_Homo sapiens_hsa047281.19745582
41Insulin secretion_Homo sapiens_hsa049111.19078954
42Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.18965456
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.18430964
44Long-term depression_Homo sapiens_hsa047301.16918487
45Renal cell carcinoma_Homo sapiens_hsa052111.16594372
46VEGF signaling pathway_Homo sapiens_hsa043701.15320773
47Adherens junction_Homo sapiens_hsa045201.14821831
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.13556229
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.12765600
50Osteoclast differentiation_Homo sapiens_hsa043801.12512578
51Adipocytokine signaling pathway_Homo sapiens_hsa049201.11812779
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08884497
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.07538327
54p53 signaling pathway_Homo sapiens_hsa041151.07429626
55Base excision repair_Homo sapiens_hsa034101.07049134
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06999042
57Endocytosis_Homo sapiens_hsa041441.06804580
58TNF signaling pathway_Homo sapiens_hsa046681.06665099
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05635056
60Legionellosis_Homo sapiens_hsa051341.05107979
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.03701125
62Glycerophospholipid metabolism_Homo sapiens_hsa005641.03654003
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03609913
64Insulin signaling pathway_Homo sapiens_hsa049101.02540717
65Estrogen signaling pathway_Homo sapiens_hsa049151.01770592
66Apoptosis_Homo sapiens_hsa042101.01123610
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99917398
68Measles_Homo sapiens_hsa051620.99536138
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.98647871
70Choline metabolism in cancer_Homo sapiens_hsa052310.96044590
71mTOR signaling pathway_Homo sapiens_hsa041500.91575988
72Pancreatic cancer_Homo sapiens_hsa052120.89756788
73Renin secretion_Homo sapiens_hsa049240.89751335
74Calcium signaling pathway_Homo sapiens_hsa040200.89458179
75Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88610011
76Herpes simplex infection_Homo sapiens_hsa051680.88429880
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.88228145
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86513166
79NOD-like receptor signaling pathway_Homo sapiens_hsa046210.86161212
80Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85255767
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84371086
82mRNA surveillance pathway_Homo sapiens_hsa030150.83912595
83Gastric acid secretion_Homo sapiens_hsa049710.83579795
84Fanconi anemia pathway_Homo sapiens_hsa034600.82987796
85Non-small cell lung cancer_Homo sapiens_hsa052230.82953441
86Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82797095
87cAMP signaling pathway_Homo sapiens_hsa040240.82484713
88Cholinergic synapse_Homo sapiens_hsa047250.82253317
89Type II diabetes mellitus_Homo sapiens_hsa049300.81270226
90Homologous recombination_Homo sapiens_hsa034400.80996649
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.80895936
92RNA polymerase_Homo sapiens_hsa030200.79173947
93HIF-1 signaling pathway_Homo sapiens_hsa040660.77306486
94Insulin resistance_Homo sapiens_hsa049310.77252376
95Regulation of autophagy_Homo sapiens_hsa041400.76506116
96Shigellosis_Homo sapiens_hsa051310.76459227
97Tight junction_Homo sapiens_hsa045300.76175642
98Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75905792
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74707173
100Inositol phosphate metabolism_Homo sapiens_hsa005620.74499408
101Glucagon signaling pathway_Homo sapiens_hsa049220.73895258
102AMPK signaling pathway_Homo sapiens_hsa041520.73689214
103ErbB signaling pathway_Homo sapiens_hsa040120.73118268
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72875626
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.72271572
106Taste transduction_Homo sapiens_hsa047420.71860200
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69739785
108Prolactin signaling pathway_Homo sapiens_hsa049170.69183752
109Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68736269
110Serotonergic synapse_Homo sapiens_hsa047260.67912905
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67723232
112Viral carcinogenesis_Homo sapiens_hsa052030.67202112
113Gap junction_Homo sapiens_hsa045400.66575726
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.66009608
115cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65514362
116Chemokine signaling pathway_Homo sapiens_hsa040620.64981738
117Malaria_Homo sapiens_hsa051440.61800970
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61688007
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61452759
120Nucleotide excision repair_Homo sapiens_hsa034200.59866790
121Prostate cancer_Homo sapiens_hsa052150.59852059
122Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59672823
123FoxO signaling pathway_Homo sapiens_hsa040680.58218544
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.57274537
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56087728
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56057893
127MAPK signaling pathway_Homo sapiens_hsa040100.54991663
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.54336296
129Purine metabolism_Homo sapiens_hsa002300.54209845
130Mismatch repair_Homo sapiens_hsa034300.54080162
131Thyroid cancer_Homo sapiens_hsa052160.53891520
132Bile secretion_Homo sapiens_hsa049760.53536898
133Tuberculosis_Homo sapiens_hsa051520.49792249
134Pyrimidine metabolism_Homo sapiens_hsa002400.48171045
135Vibrio cholerae infection_Homo sapiens_hsa051100.48089190
136Bladder cancer_Homo sapiens_hsa052190.48004331
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47533809
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.46367520
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.46198091
140Colorectal cancer_Homo sapiens_hsa052100.45237159
141Arginine biosynthesis_Homo sapiens_hsa002200.42491592
142Hepatitis B_Homo sapiens_hsa051610.41420029
143Biosynthesis of amino acids_Homo sapiens_hsa012300.41195758
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40853937
145Folate biosynthesis_Homo sapiens_hsa007900.38856372
146Cocaine addiction_Homo sapiens_hsa050300.38303730
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.36737044
148Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.36004975
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35500296

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