FBXO38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)8.85363337
2polyketide metabolic process (GO:0030638)8.85363337
3doxorubicin metabolic process (GO:0044598)8.85363337
4protein localization to kinetochore (GO:0034501)6.49713015
5negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)6.09171042
6maintenance of protein location in nucleus (GO:0051457)6.04163994
7cellular extravasation (GO:0045123)5.72139167
8regulation of telomere maintenance via telomerase (GO:0032210)5.68849800
9nuclear pore complex assembly (GO:0051292)5.64418143
10aminoglycoside antibiotic metabolic process (GO:0030647)5.54327903
11negative regulation of cell cycle G2/M phase transition (GO:1902750)5.47078794
12negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.46464587
13somite rostral/caudal axis specification (GO:0032525)5.44725632
14histone H4-K5 acetylation (GO:0043981)5.32819518
15histone H4-K8 acetylation (GO:0043982)5.32819518
16regulation of mammary gland epithelial cell proliferation (GO:0033599)5.18854594
17muscle organ morphogenesis (GO:0048644)5.16984939
18histone H4-K12 acetylation (GO:0043983)5.15293118
19phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)5.11258748
20mitotic sister chromatid segregation (GO:0000070)5.04443700
21nuclear pore organization (GO:0006999)5.00788892
22regulation of nuclear cell cycle DNA replication (GO:0033262)4.99711860
23negative regulation of epidermis development (GO:0045683)4.99539530
24regulation of response to osmotic stress (GO:0047484)4.95301632
25protein localization to chromosome, centromeric region (GO:0071459)4.89068589
26negative regulation of telomerase activity (GO:0051974)4.87172485
27heterochromatin organization (GO:0070828)4.86325473
28pre-miRNA processing (GO:0031054)4.74829116
29sister chromatid segregation (GO:0000819)4.74196634
30DNA replication-dependent nucleosome assembly (GO:0006335)4.65528817
31DNA replication-dependent nucleosome organization (GO:0034723)4.65528817
32positive regulation of gamma-delta T cell activation (GO:0046645)4.57414040
33chromatin assembly (GO:0031497)4.50501396
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.46271434
35rRNA transcription (GO:0009303)4.46175298
36neutrophil mediated immunity (GO:0002446)4.45640274
37positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.34989921
38regulation of B cell receptor signaling pathway (GO:0050855)4.24385184
39pore complex assembly (GO:0046931)4.24160161
40regulation of MHC class I biosynthetic process (GO:0045343)4.21364224
41histone H4-K16 acetylation (GO:0043984)4.10866383
42mitotic chromosome condensation (GO:0007076)4.03050665
43monoubiquitinated protein deubiquitination (GO:0035520)4.02082700
44notochord development (GO:0030903)4.01720348
45primitive streak formation (GO:0090009)3.94254542
46detection of molecule of bacterial origin (GO:0032490)3.89096067
47cellular response to ethanol (GO:0071361)3.88825225
48interferon-gamma production (GO:0032609)3.87879521
49myeloid leukocyte mediated immunity (GO:0002444)3.85419590
50mRNA stabilization (GO:0048255)3.80438537
51RNA stabilization (GO:0043489)3.80438537
52regulation of translation in response to stress (GO:0043555)3.79631642
53positive regulation of protein deacetylation (GO:0090312)3.75029069
54regulation of cilium movement (GO:0003352)3.73964030
55positive regulation of DNA-dependent DNA replication (GO:2000105)3.71777591
56positive regulation of histone deacetylation (GO:0031065)3.70314487
57DNA duplex unwinding (GO:0032508)3.67622444
58NLS-bearing protein import into nucleus (GO:0006607)3.67449587
59hormone catabolic process (GO:0042447)3.67330227
60regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.66727999
61negative regulation of epidermal cell differentiation (GO:0045605)3.65528308
62DNA geometric change (GO:0032392)3.63469872
63microglial cell activation (GO:0001774)3.61300406
64branching involved in mammary gland duct morphogenesis (GO:0060444)3.57870888
65DNA replication checkpoint (GO:0000076)3.56607385
66negative regulation of telomere maintenance (GO:0032205)3.54805443
67intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.52112293
68positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.52051866
69DNA unwinding involved in DNA replication (GO:0006268)3.48695698
70regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.48470962
71regulation of posttranscriptional gene silencing (GO:0060147)3.48103036
72regulation of gene silencing by miRNA (GO:0060964)3.48103036
73regulation of gene silencing by RNA (GO:0060966)3.48103036
74maintenance of protein localization in organelle (GO:0072595)3.47374352
75negative regulation of cell killing (GO:0031342)3.44896714
76negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44896714
77cytidine deamination (GO:0009972)3.41170160
78cytidine metabolic process (GO:0046087)3.41170160
79cytidine catabolic process (GO:0006216)3.41170160
80regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.39463720
81rRNA methylation (GO:0031167)3.38746834
82cell fate commitment involved in formation of primary germ layer (GO:0060795)3.37227796
83modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34569313
84positive regulation by organism of defense response of other organism involved in symbiotic interact3.34569313
85modulation by symbiont of host immune response (GO:0052553)3.34569313
86positive regulation by symbiont of host defense response (GO:0052509)3.34569313
87modulation by symbiont of host defense response (GO:0052031)3.34569313
88modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34569313
89regulation of telomere maintenance (GO:0032204)3.33078848
90histone mRNA catabolic process (GO:0071044)3.31583467
91regulation of interferon-beta biosynthetic process (GO:0045357)3.28645563
92nucleoside transmembrane transport (GO:1901642)3.27353138
93trophectodermal cell differentiation (GO:0001829)3.24844483
94macrophage activation involved in immune response (GO:0002281)3.24358200
95negative regulation of interleukin-12 production (GO:0032695)3.19649465
96regulation of apoptotic process involved in morphogenesis (GO:1902337)3.18572665
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17192487
98response to dietary excess (GO:0002021)3.16280682
99definitive hemopoiesis (GO:0060216)3.15031876
100phenol-containing compound catabolic process (GO:0019336)3.14746186
101regulation of gamma-delta T cell activation (GO:0046643)3.14508079
102iron ion import (GO:0097286)3.13017957
103response to interleukin-15 (GO:0070672)3.12513937
104microtubule severing (GO:0051013)3.07580581
105histone H3-K36 demethylation (GO:0070544)3.06858951
106intestinal epithelial cell development (GO:0060576)3.06622999
107regulation of MHC class II biosynthetic process (GO:0045346)3.06154902
108retinoic acid receptor signaling pathway (GO:0048384)3.02253672
109establishment of protein localization to Golgi (GO:0072600)3.02105570
110detection of other organism (GO:0098543)3.00932140
111negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.97982667
112chromosome condensation (GO:0030261)2.97255367
113antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.97062132
114macrophage activation (GO:0042116)2.96510939
115rRNA modification (GO:0000154)2.96470626
116regulation of telomerase activity (GO:0051972)2.91591436
117protein targeting to Golgi (GO:0000042)2.89729144
118spindle assembly (GO:0051225)2.88629131
119mitotic nuclear envelope disassembly (GO:0007077)2.88585329
120B cell receptor signaling pathway (GO:0050853)2.88335778
121DNA conformation change (GO:0071103)2.87974411
122detection of external biotic stimulus (GO:0098581)2.87873426
123interleukin-6-mediated signaling pathway (GO:0070102)2.86580184
124histone H3-K4 methylation (GO:0051568)2.85170276
125early endosome to late endosome transport (GO:0045022)2.84689637
126maternal placenta development (GO:0001893)2.83352942
127regulation of B cell differentiation (GO:0045577)2.82604123
128intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.82454017
129cellular response to interleukin-15 (GO:0071350)2.81902881
130retrograde transport, vesicle recycling within Golgi (GO:0000301)2.81582277
131regulation of gamma-delta T cell differentiation (GO:0045586)2.80827272
132cardiovascular system development (GO:0072358)2.80511600
133bone trabecula formation (GO:0060346)2.77492680
134regulation of double-strand break repair (GO:2000779)2.77145346
135regulation of interleukin-8 biosynthetic process (GO:0045414)2.76930420
136regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.76851961
137hepatocyte apoptotic process (GO:0097284)2.74357351
138negative regulation of B cell proliferation (GO:0030889)2.74178144
139histone H3-K4 trimethylation (GO:0080182)2.73333317
140membrane disassembly (GO:0030397)2.73008037
141nuclear envelope disassembly (GO:0051081)2.73008037
142protein localization to chromosome (GO:0034502)2.72105730
143germinal center formation (GO:0002467)2.72057876
144coenzyme catabolic process (GO:0009109)2.70796347
145neural tube formation (GO:0001841)2.70640643
146DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.69273133
147T cell migration (GO:0072678)2.68853461
148regulation of hippo signaling (GO:0035330)2.68669031
149B cell proliferation (GO:0042100)2.68519325
150chromatin assembly or disassembly (GO:0006333)2.66401380
151positive regulation of interferon-alpha production (GO:0032727)2.66185726
152formation of translation preinitiation complex (GO:0001731)2.65533503
153vitamin A metabolic process (GO:0006776)2.64544218
154I-kappaB phosphorylation (GO:0007252)2.64506870
155negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.64492667
156negative regulation of T-helper cell differentiation (GO:0045623)2.64492667
157positive regulation of mitotic sister chromatid separation (GO:1901970)2.64163667
158positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.64163667
159positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.64163667
160cellular modified amino acid catabolic process (GO:0042219)2.64163468
161embryonic process involved in female pregnancy (GO:0060136)2.62808794
162negative regulation of gene silencing (GO:0060969)2.62770285
163positive regulation of interferon-beta production (GO:0032728)2.62658706
164positive regulation of granulocyte differentiation (GO:0030854)2.60295148
165regulation of DNA damage checkpoint (GO:2000001)2.58971315
166regulation of interferon-alpha production (GO:0032647)2.58447409
167COPII vesicle coating (GO:0048208)2.57056357
168positive regulation of cellular amide metabolic process (GO:0034250)2.55468110
169phospholipid homeostasis (GO:0055091)2.54850686
170negative regulation of lymphocyte mediated immunity (GO:0002707)2.54729405
171negative regulation of T cell mediated immunity (GO:0002710)2.53080592
172response to lipoprotein particle (GO:0055094)2.51504339
173production of molecular mediator involved in inflammatory response (GO:0002532)2.50571057
174dorsal/ventral axis specification (GO:0009950)2.49148028
175positive regulation of B cell differentiation (GO:0045579)2.48482595
176positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47704288
177myeloid cell activation involved in immune response (GO:0002275)2.45968615
178negative T cell selection (GO:0043383)2.45511669
179detection of biotic stimulus (GO:0009595)2.41915952
180dosage compensation (GO:0007549)2.41308177
181peptidyl-lysine trimethylation (GO:0018023)2.41077294
182regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.40372523
183negative regulation of neurotransmitter transport (GO:0051589)2.39970430
184negative regulation of complement activation (GO:0045916)2.39926287
185negative regulation of protein activation cascade (GO:2000258)2.38858105
186negative thymic T cell selection (GO:0045060)2.38805026
187regulation of interleukin-12 biosynthetic process (GO:0045075)2.38054152
188growth hormone receptor signaling pathway (GO:0060396)2.37173147
189respiratory burst (GO:0045730)2.36571215
190positive T cell selection (GO:0043368)2.35207408
191negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.33335473
192olfactory bulb development (GO:0021772)2.32492457
193regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.31628831
194protein K11-linked deubiquitination (GO:0035871)2.31546025
195negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.31507030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.18693450
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.59076534
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.59076534
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.59076534
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.62269690
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.23451086
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.80745114
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.41058604
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.39369044
10SMAD_19615063_ChIP-ChIP_OVARY_Human3.35515690
11TP63_19390658_ChIP-ChIP_HaCaT_Human3.17566486
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98260973
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.95014111
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.92557825
15NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.90779607
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.85557670
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.70168450
18SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.58755106
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55676857
20SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.39238500
21IRF8_21731497_ChIP-ChIP_J774_Mouse2.38598823
22TCF3_18692474_ChIP-Seq_MESCs_Mouse2.29768736
23POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29147980
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.22327982
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.21947277
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.20949419
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.19618320
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.18744251
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.15681927
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.09680362
31EGR1_19374776_ChIP-ChIP_THP-1_Human2.08433249
32IRF8_27001747_Chip-Seq_BMDM_Mouse2.06511554
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04005693
34MYC_22102868_ChIP-Seq_BL_Human1.99865323
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98279876
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.96995613
37ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94134587
38NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.89500176
39RUNX_20019798_ChIP-Seq_JUKART_Human1.82879806
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.81922602
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81677359
42AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.76245203
43NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.76140334
44* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.73562098
45TAF15_26573619_Chip-Seq_HEK293_Human1.71130535
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.71100773
47IGF1R_20145208_ChIP-Seq_DFB_Human1.70345667
48* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69865349
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.68995368
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67256544
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.67246323
52SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65812987
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.61318248
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60086786
55EZH2_27294783_Chip-Seq_NPCs_Mouse1.59806808
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57399548
57MYB_26560356_Chip-Seq_TH2_Human1.55012950
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54987863
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54548009
60CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.54064177
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.53582240
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52987806
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52716082
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.51324403
65TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.51181435
66POU5F1_16518401_ChIP-PET_MESCs_Mouse1.50176689
67MYC_19079543_ChIP-ChIP_MESCs_Mouse1.50171227
68MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49087731
69FUS_26573619_Chip-Seq_HEK293_Human1.47803768
70POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46975995
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.45151370
72* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.43976467
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.43701045
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.43133003
75CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.42452261
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.42421656
77GATA1_22025678_ChIP-Seq_K562_Human1.42255485
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.41486499
79VDR_24787735_ChIP-Seq_THP-1_Human1.41217919
80PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40192772
81ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38741741
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.35395782
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.35354691
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.33802765
85ZFP281_27345836_Chip-Seq_ESCs_Mouse1.33100376
86NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32033847
87TCF7_22412390_ChIP-Seq_EML_Mouse1.31841673
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.31795491
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30300093
90PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29872927
91GATA3_27048872_Chip-Seq_THYMUS_Human1.28549372
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26820103
93POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26701564
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26304093
95IRF1_19129219_ChIP-ChIP_H3396_Human1.26217472
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.25888969
97NANOG_18692474_ChIP-Seq_MEFs_Mouse1.25751377
98SOX2_18692474_ChIP-Seq_MESCs_Mouse1.25609090
99ZNF274_21170338_ChIP-Seq_K562_Hela1.25520976
100OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25251211
101SMAD4_21799915_ChIP-Seq_A2780_Human1.24906991
102* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24703852
103* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24123860
104NANOG_18555785_Chip-Seq_ESCs_Mouse1.23878919
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.23598225
106PU_27001747_Chip-Seq_BMDM_Mouse1.23422754
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.22895384
108PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.22372284
109ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21216478
110STAT3_23295773_ChIP-Seq_U87_Human1.21205793
111OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20500464
112GBX2_23144817_ChIP-Seq_PC3_Human1.20122391
113* SPI1_23547873_ChIP-Seq_NB4_Human1.20072839
114ER_23166858_ChIP-Seq_MCF-7_Human1.18753284
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18364050
116EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18326786
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17847719
118* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17643709
119SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17100132
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.15654102
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.15362256
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15254002
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15254002
124NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.15041632
125AHR_22903824_ChIP-Seq_MCF-7_Human1.14718118
126* GATA3_26560356_Chip-Seq_TH2_Human1.14657643
127ARNT_22903824_ChIP-Seq_MCF-7_Human1.13902946
128CMYC_18555785_Chip-Seq_ESCs_Mouse1.13671560
129CRX_20693478_ChIP-Seq_RETINA_Mouse1.12350662
130BRD4_25478319_ChIP-Seq_HGPS_Human1.12116837
131SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11792778
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11576227
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11576227
134P300_18555785_Chip-Seq_ESCs_Mouse1.11505199
135EWS_26573619_Chip-Seq_HEK293_Human1.10461557
136OCT4_18692474_ChIP-Seq_MEFs_Mouse1.10019938
137* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09951269
138* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09501477
139PIAS1_25552417_ChIP-Seq_VCAP_Human1.08717609
140SCL_19346495_ChIP-Seq_HPC-7_Human1.07924845
141NCOR1_26117541_ChIP-Seq_K562_Human1.07849264
142P300_19829295_ChIP-Seq_ESCs_Human1.07711447
143SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06914387
144E2F1_17053090_ChIP-ChIP_MCF-7_Human1.05569227
145* SALL4_22934838_ChIP-ChIP_CD34+_Human1.05039127
146FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04700884
147YY1_21170310_ChIP-Seq_MESCs_Mouse1.04421832
148NANOG_16518401_ChIP-PET_MESCs_Mouse1.03603583
149CIITA_25753668_ChIP-Seq_RAJI_Human1.03298685
150TP53_16413492_ChIP-PET_HCT116_Human1.02939950
151P53_22387025_ChIP-Seq_ESCs_Mouse1.02853739
152NANOG_16153702_ChIP-ChIP_HESCs_Human1.02692123
153MYC_18358816_ChIP-ChIP_MESCs_Mouse1.01365912
154CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01154843
155EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99626145
156NMYC_18555785_Chip-Seq_ESCs_Mouse0.99564435
157* TCF4_23295773_ChIP-Seq_U87_Human0.99562847
158VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99511754
159SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99418782
160CDX2_22108803_ChIP-Seq_LS180_Human0.97468256
161TP53_22127205_ChIP-Seq_IMR90_Human0.95103301
162* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.94841586
163KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94249804
164NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94163701
165POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92517271
166KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91166478
167SALL1_21062744_ChIP-ChIP_HESCs_Human0.90089035
168KDM5A_27292631_Chip-Seq_BREAST_Human0.89098852
169FOXP3_21729870_ChIP-Seq_TREG_Human0.87955765
170FOXO3_23340844_ChIP-Seq_DLD1_Human0.86952020
171KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.85257668
172TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84923704
173ELK3_25401928_ChIP-Seq_HUVEC_Human0.84119848
174TBX3_20139965_ChIP-Seq_MESCs_Mouse0.83556609
175CREB1_15753290_ChIP-ChIP_HEK293T_Human0.82511761
176TFEB_21752829_ChIP-Seq_HELA_Human0.81808532
177MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81402767
178PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80698947
179E2F1_21310950_ChIP-Seq_MCF-7_Human0.80686320
180NOTCH1_21737748_ChIP-Seq_TLL_Human0.80477784
181CDX2_20551321_ChIP-Seq_CACO-2_Human0.78318009
182* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.77704011
183* AR_21909140_ChIP-Seq_LNCAP_Human0.76125213
184MYB_26560356_Chip-Seq_TH1_Human0.76095281
185HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75364137
186XRN2_22483619_ChIP-Seq_HELA_Human0.73127666
187* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.72969301
188KAP1_27257070_Chip-Seq_ESCs_Mouse0.72635810
189TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.72087909
190SOX2_16153702_ChIP-ChIP_HESCs_Human0.71889244
191SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71510330
192KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70893918

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004264_abnormal_extraembryonic_tissu4.27018345
2MP0002254_reproductive_system_inflammat4.04418374
3MP0003724_increased_susceptibility_to3.70683014
4MP0003890_abnormal_embryonic-extraembry3.62768101
5MP0003011_delayed_dark_adaptation3.61191694
6MP0000569_abnormal_digit_pigmentation3.12299738
7MP0006292_abnormal_olfactory_placode3.07454549
8MP0010352_gastrointestinal_tract_polyps2.99400461
9MP0008057_abnormal_DNA_replication2.96745554
10MP0003705_abnormal_hypodermis_morpholog2.90457123
11MP0004957_abnormal_blastocyst_morpholog2.78007095
12MP0003303_peritoneal_inflammation2.74793425
13MP0002653_abnormal_ependyma_morphology2.74412036
14MP0006054_spinal_hemorrhage2.73059528
15MP0003656_abnormal_erythrocyte_physiolo2.69637770
16MP0003122_maternal_imprinting2.66350317
17MP0003300_gastrointestinal_ulcer2.64756279
18MP0003121_genomic_imprinting2.64386290
19MP0008260_abnormal_autophagy2.58374288
20MP0004858_abnormal_nervous_system2.54118553
21MP0003221_abnormal_cardiomyocyte_apopto2.40509895
22MP0005075_abnormal_melanosome_morpholog2.38847727
23MP0005394_taste/olfaction_phenotype2.36413446
24MP0005499_abnormal_olfactory_system2.36413446
25MP0002009_preneoplasia2.29884073
26MP0003763_abnormal_thymus_physiology2.26755388
27MP0005257_abnormal_intraocular_pressure2.26381959
28MP0001835_abnormal_antigen_presentation2.22591839
29MP0008877_abnormal_DNA_methylation2.18149331
30MP0003436_decreased_susceptibility_to2.13595895
31MP0003828_pulmonary_edema2.04699209
32MP0005380_embryogenesis_phenotype2.03726462
33MP0001672_abnormal_embryogenesis/_devel2.03726462
34MP0003191_abnormal_cellular_cholesterol2.03682547
35MP0003077_abnormal_cell_cycle2.02339436
36MP0002332_abnormal_exercise_endurance2.01100399
37MP0002419_abnormal_innate_immunity1.93626084
38MP0002088_abnormal_embryonic_growth/wei1.92407821
39MP0003984_embryonic_growth_retardation1.91432330
40MP0001800_abnormal_humoral_immune1.90534030
41MP0008961_abnormal_basal_metabolism1.86403851
42MP0002166_altered_tumor_susceptibility1.85062458
43MP0003183_abnormal_peptide_metabolism1.78327520
44MP0000685_abnormal_immune_system1.77992505
45MP0001849_ear_inflammation1.77540921
46MP0000350_abnormal_cell_proliferation1.76788168
47MP0009785_altered_susceptibility_to1.76005570
48MP0010030_abnormal_orbit_morphology1.72188639
49MP0010094_abnormal_chromosome_stability1.66031257
50MP0001293_anophthalmia1.64020173
51MP0006035_abnormal_mitochondrial_morpho1.63526554
52MP0003111_abnormal_nucleus_morphology1.62476312
53MP0003123_paternal_imprinting1.62352349
54MP0002086_abnormal_extraembryonic_tissu1.62226144
55MP0004883_abnormal_blood_vessel1.60098696
56MP0001790_abnormal_immune_system1.59913822
57MP0005387_immune_system_phenotype1.59913822
58MP0005000_abnormal_immune_tolerance1.57571696
59MP0005671_abnormal_response_to1.55778942
60MP0002092_abnormal_eye_morphology1.54123151
61MP0002420_abnormal_adaptive_immunity1.52199182
62MP0002452_abnormal_antigen_presenting1.50969858
63MP0002723_abnormal_immune_serum1.50754038
64MP0002085_abnormal_embryonic_tissue1.48221630
65MP0002084_abnormal_developmental_patter1.48199227
66MP0001819_abnormal_immune_cell1.47770352
67MP0001730_embryonic_growth_arrest1.45998841
68MP0002405_respiratory_system_inflammati1.45189286
69MP0000678_abnormal_parathyroid_gland1.40023027
70MP0001915_intracranial_hemorrhage1.37373141
71MP0002398_abnormal_bone_marrow1.35949652
72MP0004197_abnormal_fetal_growth/weight/1.35589668
73MP0002006_tumorigenesis1.35462819
74MP0004808_abnormal_hematopoietic_stem1.30096533
75MP0005164_abnormal_response_to1.30025658
76MP0002932_abnormal_joint_morphology1.29536264
77MP0003283_abnormal_digestive_organ1.29526614
78MP0009764_decreased_sensitivity_to1.29043454
79MP0008007_abnormal_cellular_replicative1.28657551
80MP0002396_abnormal_hematopoietic_system1.28616170
81MP0005025_abnormal_response_to1.24638855
82MP0003938_abnormal_ear_development1.20782485
83MP0000428_abnormal_craniofacial_morphol1.19519697
84MP0005464_abnormal_platelet_physiology1.18280181
85MP0005451_abnormal_body_composition1.18189988
86MP0003950_abnormal_plasma_membrane1.17841682
87MP0001697_abnormal_embryo_size1.17835295
88MP0000716_abnormal_immune_system1.17786947
89MP0000689_abnormal_spleen_morphology1.17539178
90MP0005397_hematopoietic_system_phenotyp1.16680230
91MP0001545_abnormal_hematopoietic_system1.16680230
92MP0002138_abnormal_hepatobiliary_system1.15999347
93MP0002127_abnormal_cardiovascular_syste1.15916388
94MP0002722_abnormal_immune_system1.15827868
95MP0003935_abnormal_craniofacial_develop1.15656902
96MP0004084_abnormal_cardiac_muscle1.14527763
97MP0004484_altered_response_of1.13185037
98MP0005310_abnormal_salivary_gland1.11302685
99MP0000465_gastrointestinal_hemorrhage1.11180429
100MP0002277_abnormal_respiratory_mucosa1.11052977
101MP0002638_abnormal_pupillary_reflex1.10098222
102MP0002080_prenatal_lethality1.09020523
103MP0004133_heterotaxia1.08517906
104MP0006082_CNS_inflammation1.08379813
105MP0005023_abnormal_wound_healing1.08135364
106MP0000432_abnormal_head_morphology1.07874447
107MP0003787_abnormal_imprinting1.05623675
108MP0000703_abnormal_thymus_morphology1.05152670
109MP0003119_abnormal_digestive_system1.03521262
110MP0010678_abnormal_skin_adnexa1.03299331
111MP0002925_abnormal_cardiovascular_devel1.02855844
112MP0000313_abnormal_cell_death1.02456791
113MP0001845_abnormal_inflammatory_respons1.01232030
114MP0004381_abnormal_hair_follicle1.00956808
115MP0008932_abnormal_embryonic_tissue0.99826377
116MP0001851_eye_inflammation0.99822807
117MP0008770_decreased_survivor_rate0.98262420
118MP0002114_abnormal_axial_skeleton0.96127287
119MP0001533_abnormal_skeleton_physiology0.94613660
120MP0005266_abnormal_metabolism0.94369094
121MP0003566_abnormal_cell_adhesion0.94100896
122MP0000490_abnormal_crypts_of0.92502733
123MP0002148_abnormal_hypersensitivity_rea0.92083920
124MP0003195_calcinosis0.91996113
125MP0005391_vision/eye_phenotype0.91932235
126MP0002970_abnormal_white_adipose0.91777472
127MP0000427_abnormal_hair_cycle0.91169116
128MP0010155_abnormal_intestine_physiology0.90747778
129MP0009703_decreased_birth_body0.90727610
130MP0003868_abnormal_feces_composition0.90051294
131MP0003045_fibrosis0.90046086
132MP0003567_abnormal_fetal_cardiomyocyte0.89432913
133MP0004947_skin_inflammation0.88803938
134MP0005076_abnormal_cell_differentiation0.88036574
135MP0003690_abnormal_glial_cell0.87670703
136MP0003693_abnormal_embryo_hatching0.87149149
137MP0005248_abnormal_Harderian_gland0.86152688
138MP0003755_abnormal_palate_morphology0.86051105
139MP0008789_abnormal_olfactory_epithelium0.85837070
140MP0000049_abnormal_middle_ear0.85622475
141MP0002168_other_aberrant_phenotype0.84989804
142MP0003252_abnormal_bile_duct0.84791498
143MP0004036_abnormal_muscle_relaxation0.84776913
144MP0001348_abnormal_lacrimal_gland0.84746957
145MP0009697_abnormal_copulation0.83547699
146MP0005167_abnormal_blood-brain_barrier0.82988594
147MP0002233_abnormal_nose_morphology0.81727716
148MP0000762_abnormal_tongue_morphology0.81177044
149MP0010307_abnormal_tumor_latency0.80766824
150MP0002429_abnormal_blood_cell0.80685593
151MP0005647_abnormal_sex_gland0.80095947
152MP0005508_abnormal_skeleton_morphology0.79785068
153MP0000358_abnormal_cell_content/0.79592874
154MP0005384_cellular_phenotype0.77901086
155MP0002751_abnormal_autonomic_nervous0.76478751
156MP0001853_heart_inflammation0.76090313
157MP0003091_abnormal_cell_migration0.75360228
158MP0002019_abnormal_tumor_incidence0.75270947
159MP0005376_homeostasis/metabolism_phenot0.74852703
160MP0002269_muscular_atrophy0.73907367
161MP0003448_altered_tumor_morphology0.71755818
162MP0003937_abnormal_limbs/digits/tail_de0.70101480
163MP0002116_abnormal_craniofacial_bone0.69946558
164MP0000604_amyloidosis0.69877152
165MP0009115_abnormal_fat_cell0.69138425
166MP0008469_abnormal_protein_level0.68460207
167MP0003172_abnormal_lysosome_physiology0.66656982
168MP0001286_abnormal_eye_development0.65280918
169MP0002098_abnormal_vibrissa_morphology0.65093256
170MP0003315_abnormal_perineum_morphology0.64853568
171MP0000516_abnormal_urinary_system0.64705147
172MP0002877_abnormal_melanocyte_morpholog0.64335743
173MP0003786_premature_aging0.63050335
174MP0002111_abnormal_tail_morphology0.62971020
175MP0002697_abnormal_eye_size0.62628798
176MP0000383_abnormal_hair_follicle0.62316027
177MP0005621_abnormal_cell_physiology0.61421290
178MP0000858_altered_metastatic_potential0.60989712
179MP0010234_abnormal_vibrissa_follicle0.58863641

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.45377042
2Hypochromic microcytic anemia (HP:0004840)5.90325548
3Hepatoblastoma (HP:0002884)5.12490380
4Ependymoma (HP:0002888)4.99339972
5Abnormality of the lower motor neuron (HP:0002366)4.84173352
6Multiple enchondromatosis (HP:0005701)4.44882080
7Rib fusion (HP:0000902)4.32152268
8Abnormality of the astrocytes (HP:0100707)3.92331420
9Astrocytoma (HP:0009592)3.92331420
10Neoplasm of striated muscle (HP:0009728)3.90356351
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89522993
12Abnormality of T cell number (HP:0011839)3.76387152
13T lymphocytopenia (HP:0005403)3.75734666
14Rhabdomyosarcoma (HP:0002859)3.72382953
15Subacute progressive viral hepatitis (HP:0006572)3.69366358
16Retrobulbar optic neuritis (HP:0100654)3.58146016
17Optic neuritis (HP:0100653)3.58146016
18Nephroblastoma (Wilms tumor) (HP:0002667)3.54117855
19Orchitis (HP:0100796)3.43392250
20Diastasis recti (HP:0001540)3.42485070
21Papillary thyroid carcinoma (HP:0002895)3.41621494
22Chromsome breakage (HP:0040012)3.39483871
23Embryonal renal neoplasm (HP:0011794)3.32646413
24Recurrent gram-negative bacterial infections (HP:0005420)3.30422456
25Fair hair (HP:0002286)3.20155048
26Eczematoid dermatitis (HP:0000976)3.15944791
27Myositis (HP:0100614)3.15474254
28Hyperventilation (HP:0002883)3.13428283
29Amyotrophic lateral sclerosis (HP:0007354)3.09955345
30Impulsivity (HP:0100710)3.09930944
31Recurrent bacterial skin infections (HP:0005406)3.05235436
32Spontaneous hematomas (HP:0007420)2.99703978
33Fused cervical vertebrae (HP:0002949)2.93443088
34Hematochezia (HP:0002573)2.88801048
35Recurrent abscess formation (HP:0002722)2.84307202
36Glioma (HP:0009733)2.84138068
37Keratoconjunctivitis sicca (HP:0001097)2.83810438
38Eosinophilia (HP:0001880)2.83481289
39Stomatitis (HP:0010280)2.81346480
40Abnormality of the salivary glands (HP:0010286)2.78989324
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.77767685
42Hypoplasia of the fovea (HP:0007750)2.77767685
43Curly hair (HP:0002212)2.77251490
44Short humerus (HP:0005792)2.74996902
45Thyroiditis (HP:0100646)2.74352914
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.72740277
47Preauricular skin tag (HP:0000384)2.71931041
48Aplasia/hypoplasia of the humerus (HP:0006507)2.70756438
49Keratoconjunctivitis (HP:0001096)2.67927135
50Hyperinsulinemic hypoglycemia (HP:0000825)2.67369949
51Recurrent skin infections (HP:0001581)2.67341651
52Abnormal lung lobation (HP:0002101)2.66786775
53Hypopigmentation of the fundus (HP:0007894)2.64688152
54Distal arthrogryposis (HP:0005684)2.60797929
55Bifid tongue (HP:0010297)2.59449470
56Abnormality of chromosome segregation (HP:0002916)2.59230317
57Stomach cancer (HP:0012126)2.59187502
58Recurrent fungal infections (HP:0002841)2.55310922
59Autoimmune hemolytic anemia (HP:0001890)2.54944737
60Trismus (HP:0000211)2.54354890
61Rectovaginal fistula (HP:0000143)2.52522811
62Rectal fistula (HP:0100590)2.52522811
63Thyroid carcinoma (HP:0002890)2.52437763
64Skin tags (HP:0010609)2.49559431
65Abnormality of eosinophils (HP:0001879)2.46819126
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.46714005
67Leukocytosis (HP:0001974)2.46034805
68Volvulus (HP:0002580)2.45214938
69Shawl scrotum (HP:0000049)2.44947854
70Renal duplication (HP:0000075)2.44804087
71Intestinal fistula (HP:0100819)2.43710515
72Meckel diverticulum (HP:0002245)2.43561209
73Tetraplegia (HP:0002445)2.42111793
74Viral hepatitis (HP:0006562)2.40964127
75Neoplasm of the heart (HP:0100544)2.40664472
76Hip dysplasia (HP:0001385)2.37822905
77Testicular atrophy (HP:0000029)2.36180741
78Cone-rod dystrophy (HP:0000548)2.36125026
79Hypochromic anemia (HP:0001931)2.36121916
80Abnormal cartilage morphology (HP:0002763)2.35955579
81Aplasia/Hypoplasia of the sternum (HP:0006714)2.35739008
82Horizontal nystagmus (HP:0000666)2.33185773
83Ragged-red muscle fibers (HP:0003200)2.31491984
84Abnormality of the ileum (HP:0001549)2.31031720
85Periodontitis (HP:0000704)2.30757017
86Granulocytopenia (HP:0001913)2.30129373
87Gingivitis (HP:0000230)2.29863036
88Increased connective tissue (HP:0009025)2.29658009
89Short 5th finger (HP:0009237)2.28480064
90Large earlobe (HP:0009748)2.28052158
91Anomalous pulmonary venous return (HP:0010772)2.27133270
92Hand muscle atrophy (HP:0009130)2.22443764
93Medulloblastoma (HP:0002885)2.22293671
94Combined immunodeficiency (HP:0005387)2.20933938
95Vaginal fistula (HP:0004320)2.19146805
96Upper motor neuron abnormality (HP:0002127)2.16041321
97Abnormality of macrophages (HP:0004311)2.15758366
98Acute myeloid leukemia (HP:0004808)2.15055474
99Thickened calvaria (HP:0002684)2.13703985
100Recurrent cutaneous fungal infections (HP:0011370)2.13187327
101Chronic mucocutaneous candidiasis (HP:0002728)2.13187327
102Chest pain (HP:0100749)2.12952999
103Generalized hypopigmentation of hair (HP:0011358)2.12096141
104Abnormality of small intestinal villus morphology (HP:0011472)2.11619532
105Villous atrophy (HP:0011473)2.11619532
106Supernumerary spleens (HP:0009799)2.11091310
107Submucous cleft hard palate (HP:0000176)2.10906419
108Abnormality of T cells (HP:0002843)2.10040179
109Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.09145085
110Pseudobulbar signs (HP:0002200)2.09002772
111Missing ribs (HP:0000921)2.07592905
112Aplasia/Hypoplasia of the macula (HP:0008059)2.07568329
113Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.07475619
114Abnormality of the pubic bones (HP:0003172)2.04965223
115Resting tremor (HP:0002322)2.04607782
116Duodenal stenosis (HP:0100867)2.04430317
117Small intestinal stenosis (HP:0012848)2.04430317
118Generalized hypotonia (HP:0001290)2.04014158
119Malignant neoplasm of the central nervous system (HP:0100836)2.03955680
120Abnormal foot bone ossification (HP:0010675)2.03648448
121Abnormality of the fovea (HP:0000493)2.03312925
122Glossoptosis (HP:0000162)2.03188741
123Gingival bleeding (HP:0000225)2.02236984
124Mediastinal lymphadenopathy (HP:0100721)2.02215975
125Widely spaced teeth (HP:0000687)2.00770666
126Gastrointestinal infarctions (HP:0005244)2.00333832
127Increased nuchal translucency (HP:0010880)2.00223343
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.98524048
129Cystic hygroma (HP:0000476)1.96771427
130Vertebral fusion (HP:0002948)1.95181868
131Preauricular pit (HP:0004467)1.94809350
132Periauricular skin pits (HP:0100277)1.94809350
133Prominent nose (HP:0000448)1.94252044
134Arterial thrombosis (HP:0004420)1.93640374
135Broad alveolar ridges (HP:0000187)1.93590935
136Peritonitis (HP:0002586)1.93292593
137Recurrent viral infections (HP:0004429)1.93290643
138Reduced antithrombin III activity (HP:0001976)1.90010715
139Absent frontal sinuses (HP:0002688)1.89464997
140Nasal polyposis (HP:0100582)1.89091816
141Facial diplegia (HP:0001349)1.88981507
142Coarse hair (HP:0002208)1.88975395
143Selective tooth agenesis (HP:0001592)1.88563723
144Hemoptysis (HP:0002105)1.88204880
145Keratitis (HP:0000491)1.87907831
146Abnormality of the pulmonary veins (HP:0011718)1.87275867
147Prominent occiput (HP:0000269)1.86394330
148Partial duplication of thumb phalanx (HP:0009944)1.86208283
149Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85876198
150Pulmonary infiltrates (HP:0002113)1.84768561
151Neoplasm of the oral cavity (HP:0100649)1.84744175
152Pulmonary embolism (HP:0002204)1.84107117
153Narrow palate (HP:0000189)1.83920472
154Pendular nystagmus (HP:0012043)1.83739020
155Encephalitis (HP:0002383)1.83679841
156Bicuspid aortic valve (HP:0001647)1.83401637
157Myocardial infarction (HP:0001658)1.82693267
158Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82627903
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.82494388
160Low anterior hairline (HP:0000294)1.81483903
161Lower limb hyperreflexia (HP:0002395)1.80751406
162Hypoplasia of the thymus (HP:0000778)1.80390492
163Macroorchidism (HP:0000053)1.79891619
164Conjunctival telangiectasia (HP:0000524)1.79884962
165Adenoma sebaceum (HP:0009720)1.79277397
166Angiofibromas (HP:0010615)1.79277397
167Sensory axonal neuropathy (HP:0003390)1.78793300
168Sloping forehead (HP:0000340)1.78425060
169Thrombophlebitis (HP:0004418)1.76135642
170Severe combined immunodeficiency (HP:0004430)1.75746691
171Chronic diarrhea (HP:0002028)1.74387676
172Uterine leiomyosarcoma (HP:0002891)1.74241238
173Leiomyosarcoma (HP:0100243)1.74241238
174Myelodysplasia (HP:0002863)1.74235536
175Anhidrosis (HP:0000970)1.74131388
176Recurrent bronchitis (HP:0002837)1.73756682
177Osteomyelitis (HP:0002754)1.73578735
178Slow saccadic eye movements (HP:0000514)1.72947556
179Arterial tortuosity (HP:0005116)1.71873070
180Spontaneous abortion (HP:0005268)1.71715629
181Meningitis (HP:0001287)1.69174558
182Increased CSF protein (HP:0002922)1.68269086
183Spondylolisthesis (HP:0003302)1.68164305
184Transitional cell carcinoma of the bladder (HP:0006740)1.65990522
185Bladder carcinoma (HP:0002862)1.65386541
186Bladder neoplasm (HP:0009725)1.65386541
187Subaortic stenosis (HP:0001682)1.63934161
188Abnormality of the left ventricular outflow tract (HP:0011103)1.63934161
189Neonatal hypoglycemia (HP:0001998)1.63532030
190Vasculitis (HP:0002633)1.63452023
191Panhypogammaglobulinemia (HP:0003139)1.60351088

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK128.60478474
2ERN14.56774167
3GRK53.93663294
4GRK63.83008789
5PIK3CG2.88262044
6FRK2.77486120
7TYRO32.76065095
8CSF1R2.72196292
9BMPR1B2.67586734
10STK102.55319861
11TTK2.50217363
12TGFBR22.43557030
13BLK2.33746291
14GRK12.23440883
15TIE12.11680430
16ADRBK22.07142832
17YES11.89216442
18MAP3K21.88789910
19MAPK71.87722000
20MAP3K101.83282859
21MATK1.83223815
22NLK1.79662153
23SGK21.78214470
24MAP3K41.75969573
25MAP3K141.71732228
26WNK11.71048978
27NEK91.70756173
28IRAK41.69341937
29FGFR31.61469591
30TEC1.60762749
31IRAK11.60307433
32TYK21.58192782
33GRK71.56712538
34MOS1.54688849
35PDK21.53351062
36CDK71.49139006
37RIPK41.48238592
38STK38L1.45001988
39SGK31.43715430
40EPHA21.41804639
41PAK41.39438907
42CHEK21.35676658
43CDC71.33411254
44TGFBR11.31758406
45JAK11.31398362
46FGR1.28968172
47FGFR21.26933291
48HIPK21.25522511
49MAP3K61.21153221
50NEK21.19828640
51PLK11.18485824
52CAMK41.17970664
53IKBKE1.14435771
54IRAK21.11800392
55RAF11.10879034
56CDK61.10811880
57NUAK11.09563951
58MARK21.09102682
59FES1.06979406
60ERBB31.02145321
61PRKG21.01531595
62CHEK11.00317917
63EIF2AK30.98369093
64NTRK10.96608062
65OBSCN0.95024039
66CSNK1G10.94083388
67MAP4K10.93866514
68JAK20.93751814
69LATS10.93595622
70SGK2230.91815664
71SGK4940.91815664
72ZAP700.91241083
73MTOR0.90656860
74PDGFRA0.90458607
75TXK0.89536809
76BCR0.88738849
77CAMKK20.88575610
78CAMK1G0.87762450
79ALK0.84329614
80CSK0.83324704
81ITK0.83061835
82MAP3K50.81946997
83CSNK1G20.81853175
84BRD40.81408877
85CSNK1G30.81183016
86SYK0.80001402
87JAK30.79363267
88KSR10.79255899
89RET0.79199006
90MAP2K30.79127967
91BTK0.78319713
92KSR20.78318696
93AKT30.77944256
94EPHA30.76860567
95LCK0.76821604
96ADRBK10.75712475
97RPS6KB20.75149413
98FGFR40.74320299
99ICK0.74213166
100NEK60.72339853
101STK240.72175738
102MKNK20.70903224
103AKT20.70736207
104LYN0.69332901
105CDK40.67767576
106EEF2K0.67276409
107MARK30.62071971
108WEE10.59876731
109PLK20.59613484
110CDK20.59390405
111SCYL20.58884976
112CAMK1D0.58629725
113SIK10.57874822
114PTK2B0.57374038
115MAP3K70.57325671
116PIK3CA0.57088189
117NEK10.56859528
118FGFR10.56643116
119BRSK20.56457296
120PTK20.56308985
121DYRK30.55897337
122ACVR1B0.55187820
123PDK40.53977892
124PDK30.53977892
125MAP2K40.53892042
126MAP3K10.53478580
127PRPF4B0.53440785
128FER0.53137432
129AURKB0.52933473
130ATM0.52050047
131TNIK0.51736384
132RPS6KA40.49417761
133EGFR0.49396563
134MELK0.48845728
135STK30.47836670
136CASK0.47517540
137BMPR20.47289257
138PRKAA20.47018509
139PRKAA10.46743734
140ERBB20.46031468
141ATR0.45436178
142CDK90.44974532
143STK380.44808783
144CHUK0.44038999
145TESK20.42789272
146TRIB30.42692173
147CDK10.41076391
148DYRK1B0.40825249
149RIPK10.38039653
150IGF1R0.37226724
151PASK0.32653590
152AURKA0.32313917
153MAPK100.31154276
154FLT30.31058346
155SIK30.31023620
156CSNK1E0.30235092
157SRPK10.29946630
158MAP3K90.29820475
159INSR0.29572583
160PRKCI0.29136743
161MAP3K80.29076770
162MAPK10.27685149
163MAPK140.27076042
164MAP2K60.26624708
165WNK30.24192483
166GSK3B0.23880423
167PAK10.23669121
168CSNK1D0.23276626
169PKN20.23222120
170PRKCD0.22669597
171STK40.22475613
172PDGFRB0.22241183
173LATS20.21988195
174IKBKB0.21873258
175PAK30.20712874
176HCK0.20616812
177PRKD30.20362280
178EIF2AK20.20145792

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.56904696
2Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.49806509
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.57042809
4Fructose and mannose metabolism_Homo sapiens_hsa000513.09997219
5RNA transport_Homo sapiens_hsa030132.19861428
6Osteoclast differentiation_Homo sapiens_hsa043801.99725241
7Galactose metabolism_Homo sapiens_hsa000521.95358008
8mTOR signaling pathway_Homo sapiens_hsa041501.90261131
9mRNA surveillance pathway_Homo sapiens_hsa030151.88648113
10Cell cycle_Homo sapiens_hsa041101.88536169
11Circadian rhythm_Homo sapiens_hsa047101.87899348
12Measles_Homo sapiens_hsa051621.86142219
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69612999
14DNA replication_Homo sapiens_hsa030301.66064118
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.62932225
16Thyroid cancer_Homo sapiens_hsa052161.59644845
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59596734
18One carbon pool by folate_Homo sapiens_hsa006701.58340069
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.55333168
20Caffeine metabolism_Homo sapiens_hsa002321.55221700
21Fanconi anemia pathway_Homo sapiens_hsa034601.55180230
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.50365167
23FoxO signaling pathway_Homo sapiens_hsa040681.48990796
24Hepatitis B_Homo sapiens_hsa051611.47821095
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45173476
26Arachidonic acid metabolism_Homo sapiens_hsa005901.43466207
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42926906
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42585953
29Staphylococcus aureus infection_Homo sapiens_hsa051501.41188734
30Tuberculosis_Homo sapiens_hsa051521.39390562
31Mismatch repair_Homo sapiens_hsa034301.38363519
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37981507
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34286378
34Legionellosis_Homo sapiens_hsa051341.30105295
35MicroRNAs in cancer_Homo sapiens_hsa052061.29390829
36Prolactin signaling pathway_Homo sapiens_hsa049171.29349973
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28330071
38Regulation of autophagy_Homo sapiens_hsa041401.27169236
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.26032178
40Prostate cancer_Homo sapiens_hsa052151.25730120
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25148253
42Spliceosome_Homo sapiens_hsa030401.24162710
43TNF signaling pathway_Homo sapiens_hsa046681.24088546
44p53 signaling pathway_Homo sapiens_hsa041151.19706696
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.18015283
46Linoleic acid metabolism_Homo sapiens_hsa005911.17706154
47Type II diabetes mellitus_Homo sapiens_hsa049301.15260836
48Basal cell carcinoma_Homo sapiens_hsa052171.14942537
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.14331597
50Renal cell carcinoma_Homo sapiens_hsa052111.10683503
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09489313
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09273312
53Hepatitis C_Homo sapiens_hsa051601.08490861
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07750125
55Base excision repair_Homo sapiens_hsa034101.06664132
56Glycosaminoglycan degradation_Homo sapiens_hsa005311.06422581
57Inositol phosphate metabolism_Homo sapiens_hsa005621.06331309
58Notch signaling pathway_Homo sapiens_hsa043301.05156134
59Malaria_Homo sapiens_hsa051441.04797277
60RNA degradation_Homo sapiens_hsa030181.04210456
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03882685
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03559242
63Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03302040
64Viral carcinogenesis_Homo sapiens_hsa052031.01886417
65Acute myeloid leukemia_Homo sapiens_hsa052211.00170522
66Herpes simplex infection_Homo sapiens_hsa051680.99290089
67Platelet activation_Homo sapiens_hsa046110.99257758
68Hematopoietic cell lineage_Homo sapiens_hsa046400.94222659
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.93134031
70Pathways in cancer_Homo sapiens_hsa052000.91143039
71Hippo signaling pathway_Homo sapiens_hsa043900.90437265
72Chemokine signaling pathway_Homo sapiens_hsa040620.89973966
73Selenocompound metabolism_Homo sapiens_hsa004500.88440941
74Lysine degradation_Homo sapiens_hsa003100.87654997
75Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87475979
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87411865
77Adherens junction_Homo sapiens_hsa045200.86875194
78Proteoglycans in cancer_Homo sapiens_hsa052050.84548474
79Non-small cell lung cancer_Homo sapiens_hsa052230.84489949
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.84288464
81Systemic lupus erythematosus_Homo sapiens_hsa053220.84002638
82HTLV-I infection_Homo sapiens_hsa051660.83902364
83Complement and coagulation cascades_Homo sapiens_hsa046100.82064011
84Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79518683
85Glioma_Homo sapiens_hsa052140.77596765
86Graft-versus-host disease_Homo sapiens_hsa053320.77596258
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.77350513
88Small cell lung cancer_Homo sapiens_hsa052220.76878355
89Pancreatic cancer_Homo sapiens_hsa052120.76416230
90Primary immunodeficiency_Homo sapiens_hsa053400.75621088
91ABC transporters_Homo sapiens_hsa020100.75498318
92ErbB signaling pathway_Homo sapiens_hsa040120.75003349
93Homologous recombination_Homo sapiens_hsa034400.74838184
94T cell receptor signaling pathway_Homo sapiens_hsa046600.74721200
95Hedgehog signaling pathway_Homo sapiens_hsa043400.74482701
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73008713
97Colorectal cancer_Homo sapiens_hsa052100.72236365
98Autoimmune thyroid disease_Homo sapiens_hsa053200.71090875
99Other glycan degradation_Homo sapiens_hsa005110.68444855
100AMPK signaling pathway_Homo sapiens_hsa041520.67799933
101Choline metabolism in cancer_Homo sapiens_hsa052310.66805854
102Apoptosis_Homo sapiens_hsa042100.66374851
103Antigen processing and presentation_Homo sapiens_hsa046120.65952473
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.65739717
105Pentose phosphate pathway_Homo sapiens_hsa000300.65215445
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.65010182
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64778807
108Allograft rejection_Homo sapiens_hsa053300.60326179
109African trypanosomiasis_Homo sapiens_hsa051430.60207032
110Chronic myeloid leukemia_Homo sapiens_hsa052200.60028820
111B cell receptor signaling pathway_Homo sapiens_hsa046620.59619857
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58892267
113Bladder cancer_Homo sapiens_hsa052190.58760318
114Amoebiasis_Homo sapiens_hsa051460.57740118
115Rap1 signaling pathway_Homo sapiens_hsa040150.56264148
116Type I diabetes mellitus_Homo sapiens_hsa049400.55791440
117Non-homologous end-joining_Homo sapiens_hsa034500.54943313
118VEGF signaling pathway_Homo sapiens_hsa043700.54225837
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52718836
120Viral myocarditis_Homo sapiens_hsa054160.50305897
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.50240924
122Wnt signaling pathway_Homo sapiens_hsa043100.49698568
123Basal transcription factors_Homo sapiens_hsa030220.49323768
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48959187
125Dorso-ventral axis formation_Homo sapiens_hsa043200.47925380
126Nitrogen metabolism_Homo sapiens_hsa009100.47384689
127Nucleotide excision repair_Homo sapiens_hsa034200.47296525
128Influenza A_Homo sapiens_hsa051640.46199390
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.45743749
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45497092
131Insulin signaling pathway_Homo sapiens_hsa049100.44895462
132Biosynthesis of amino acids_Homo sapiens_hsa012300.44433804
133Insulin resistance_Homo sapiens_hsa049310.44031663
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.43509638
135Endometrial cancer_Homo sapiens_hsa052130.43064388
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42739217
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42509524
138Focal adhesion_Homo sapiens_hsa045100.41787826
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41442773
140Fatty acid biosynthesis_Homo sapiens_hsa000610.41229594
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.40905931
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40484809
143Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40212615
144Ovarian steroidogenesis_Homo sapiens_hsa049130.39296855
145Tight junction_Homo sapiens_hsa045300.39211503
146Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38503196
147Toxoplasmosis_Homo sapiens_hsa051450.37882378
148TGF-beta signaling pathway_Homo sapiens_hsa043500.37774452
149Leishmaniasis_Homo sapiens_hsa051400.37244573
150Oocyte meiosis_Homo sapiens_hsa041140.36816172
151HIF-1 signaling pathway_Homo sapiens_hsa040660.35161876

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