FBXO43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)7.93250256
2cilium or flagellum-dependent cell motility (GO:0001539)6.36217959
3axonemal dynein complex assembly (GO:0070286)5.90609683
4DNA methylation involved in gamete generation (GO:0043046)5.62104933
5multicellular organism reproduction (GO:0032504)5.61103898
6regulation of female gonad development (GO:2000194)5.55253018
7male meiosis (GO:0007140)5.51489387
8* meiotic cell cycle (GO:0051321)5.05510767
9cilium movement (GO:0003341)4.85736291
10epithelial cilium movement (GO:0003351)4.85169667
11female gamete generation (GO:0007292)4.79922584
12behavioral response to nicotine (GO:0035095)4.77423773
13regulation of meiosis I (GO:0060631)4.67539768
14microtubule depolymerization (GO:0007019)4.46752237
15centriole replication (GO:0007099)4.27786395
16* regulation of meiosis (GO:0040020)4.24469073
17centriole assembly (GO:0098534)4.22624632
18motile cilium assembly (GO:0044458)4.16119186
19male meiosis I (GO:0007141)4.13606710
20reproduction (GO:0000003)4.07195199
21glycerophospholipid catabolic process (GO:0046475)4.06655790
22epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.05793875
23female gonad development (GO:0008585)3.92410664
24microtubule severing (GO:0051013)3.85155749
25single fertilization (GO:0007338)3.71760256
26maturation of 5.8S rRNA (GO:0000460)3.64806103
27mitotic metaphase plate congression (GO:0007080)3.64713054
28* regulation of meiotic cell cycle (GO:0051445)3.61906731
29fertilization (GO:0009566)3.52175791
30microtubule polymerization or depolymerization (GO:0031109)3.51717635
31reciprocal meiotic recombination (GO:0007131)3.48191498
32reciprocal DNA recombination (GO:0035825)3.48191498
33meiotic chromosome segregation (GO:0045132)3.48106440
34DNA damage response, signal transduction resulting in transcription (GO:0042772)3.44251091
35protein K6-linked ubiquitination (GO:0085020)3.42142460
36DNA damage induced protein phosphorylation (GO:0006975)3.36899894
37DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.36689734
38cellular ketone body metabolic process (GO:0046950)3.36563639
39oocyte maturation (GO:0001556)3.36152417
40fucose catabolic process (GO:0019317)3.34954515
41L-fucose metabolic process (GO:0042354)3.34954515
42L-fucose catabolic process (GO:0042355)3.34954515
43axoneme assembly (GO:0035082)3.33848935
44fusion of sperm to egg plasma membrane (GO:0007342)3.29450977
45meiosis I (GO:0007127)3.29205476
46negative regulation of execution phase of apoptosis (GO:1900118)3.27890528
47double-strand break repair via homologous recombination (GO:0000724)3.27650442
48recombinational repair (GO:0000725)3.27210291
49DNA methylation (GO:0006306)3.26284966
50DNA alkylation (GO:0006305)3.26284966
51DNA deamination (GO:0045006)3.25541343
52regulation of DNA methylation (GO:0044030)3.22902466
53meiotic nuclear division (GO:0007126)3.22848347
54synaptonemal complex organization (GO:0070193)3.22677142
55sperm-egg recognition (GO:0035036)3.20682588
56attachment of spindle microtubules to kinetochore (GO:0008608)3.19767925
57regulation of DNA endoreduplication (GO:0032875)3.18784704
58resolution of meiotic recombination intermediates (GO:0000712)3.18246483
59metaphase plate congression (GO:0051310)3.17099623
60regulation of acrosome reaction (GO:0060046)3.14422105
61protein complex biogenesis (GO:0070271)3.13983956
62regulation of nuclear cell cycle DNA replication (GO:0033262)3.12165998
63pseudouridine synthesis (GO:0001522)3.11692438
64mitochondrial respiratory chain complex I assembly (GO:0032981)3.11516174
65NADH dehydrogenase complex assembly (GO:0010257)3.11516174
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11516174
67positive regulation of meiosis (GO:0045836)3.09941813
68protein polyglutamylation (GO:0018095)3.09156523
69ketone body metabolic process (GO:1902224)3.08674200
70replication fork processing (GO:0031297)3.07886921
71acrosome reaction (GO:0007340)3.06542301
72synaptonemal complex assembly (GO:0007130)3.05263304
73protein-cofactor linkage (GO:0018065)3.05206406
74response to pheromone (GO:0019236)3.04645672
75water-soluble vitamin biosynthetic process (GO:0042364)3.03862266
76positive regulation of histone H3-K4 methylation (GO:0051571)3.03699737
77binding of sperm to zona pellucida (GO:0007339)3.03471328
78mitochondrial respiratory chain complex assembly (GO:0033108)3.02360120
79postreplication repair (GO:0006301)3.02146981
80meiotic cell cycle process (GO:1903046)3.01617186
81somatic hypermutation of immunoglobulin genes (GO:0016446)3.00191104
82somatic diversification of immune receptors via somatic mutation (GO:0002566)3.00191104
83regulation of histone H3-K27 methylation (GO:0061085)2.99816517
84establishment of chromosome localization (GO:0051303)2.99488904
85negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.97797255
86positive regulation of meiotic cell cycle (GO:0051446)2.97213282
87respiratory chain complex IV assembly (GO:0008535)2.96561458
88histone exchange (GO:0043486)2.96302049
89sperm motility (GO:0030317)2.95552162
90CENP-A containing nucleosome assembly (GO:0034080)2.95413454
91cellular response to gamma radiation (GO:0071480)2.94942985
92translesion synthesis (GO:0019985)2.94536469
93retinal cone cell development (GO:0046549)2.94402076
94intraciliary transport (GO:0042073)2.93945052
95gamete generation (GO:0007276)2.92732342
96proteasome assembly (GO:0043248)2.91723833
97kinetochore assembly (GO:0051382)2.91321357
98righting reflex (GO:0060013)2.90255650
99negative regulation of telomere maintenance (GO:0032205)2.89706170
100mannosylation (GO:0097502)2.88615631
101chromosome organization involved in meiosis (GO:0070192)2.87064996
102platelet dense granule organization (GO:0060155)2.85512544
103exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82862453
104nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.82852880
105preassembly of GPI anchor in ER membrane (GO:0016254)2.82399142
106negative regulation of homotypic cell-cell adhesion (GO:0034111)2.81695554
107cilium assembly (GO:0042384)2.80540716
108positive regulation of megakaryocyte differentiation (GO:0045654)2.79791193
109histone H2A acetylation (GO:0043968)2.79755571
110chromatin remodeling at centromere (GO:0031055)2.78812607
111oogenesis (GO:0048477)2.78037527
112cilium organization (GO:0044782)2.77007158
113regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.76820257
114RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.76352394
115DNA double-strand break processing (GO:0000729)2.76109457
116sister chromatid cohesion (GO:0007062)2.76008190
117regulation of cilium movement (GO:0003352)2.75512827
118eye photoreceptor cell differentiation (GO:0001754)2.74309546
119photoreceptor cell differentiation (GO:0046530)2.74309546
120spermatogenesis (GO:0007283)2.73954886
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.73746206
122male gamete generation (GO:0048232)2.73647214
123cell-cell recognition (GO:0009988)2.73429544
124regulation of RIG-I signaling pathway (GO:0039535)2.72620405
125synapsis (GO:0007129)2.72383520
126negative regulation of DNA-templated transcription, elongation (GO:0032785)2.72317783
127negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.72317783
128spermatid development (GO:0007286)2.71443451
129gene silencing by RNA (GO:0031047)2.70346211
130mismatch repair (GO:0006298)2.70079439
131kinetochore organization (GO:0051383)2.68138748
132somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.67685784
133isotype switching (GO:0045190)2.67685784
134somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.67685784
135neuron cell-cell adhesion (GO:0007158)2.65592625
136DNA replication checkpoint (GO:0000076)2.65397756
137cullin deneddylation (GO:0010388)2.65293770
138cytochrome complex assembly (GO:0017004)2.64059327
139regulation of spindle checkpoint (GO:0090231)2.64022406
140positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.63441963
141positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.63441963
142positive regulation of mitotic sister chromatid separation (GO:1901970)2.63441963
143regulation of exit from mitosis (GO:0007096)2.61613547
144cornea development in camera-type eye (GO:0061303)2.60764461
145replicative senescence (GO:0090399)2.60763971
146positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.60393928
147microtubule nucleation (GO:0007020)2.59259473
148* negative regulation of meiotic cell cycle (GO:0051447)2.58790454
149ubiquinone biosynthetic process (GO:0006744)2.58519412
150detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58385821
151negative regulation of DNA-dependent DNA replication (GO:2000104)2.58099514
152regulation of centrosome cycle (GO:0046605)2.56961863
153monoubiquitinated protein deubiquitination (GO:0035520)2.56900371
154DNA recombination (GO:0006310)2.56446366
155regulation of mitotic spindle checkpoint (GO:1903504)2.55383791
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.55383791
157maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.55089191
158nucleotide-excision repair, DNA gap filling (GO:0006297)2.54878335
159indolalkylamine metabolic process (GO:0006586)2.54462971
160protein deneddylation (GO:0000338)2.51872774
161DNA ligation (GO:0006266)2.51772480
162detection of light stimulus involved in visual perception (GO:0050908)2.50933851
163detection of light stimulus involved in sensory perception (GO:0050962)2.50933851
164nonmotile primary cilium assembly (GO:0035058)2.50606017
165cilium morphogenesis (GO:0060271)2.49572881

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.92440697
2ZNF274_21170338_ChIP-Seq_K562_Hela3.84228391
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33672746
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.08676388
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.85611382
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77558506
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.76509949
8GBX2_23144817_ChIP-Seq_PC3_Human2.63922415
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.63757787
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.54215307
11E2F7_22180533_ChIP-Seq_HELA_Human2.53999667
12PCGF2_27294783_Chip-Seq_ESCs_Mouse2.53399965
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39104538
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.38426676
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37218518
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33136667
17VDR_22108803_ChIP-Seq_LS180_Human2.33036909
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.28818929
19POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26557351
20SMAD_19615063_ChIP-ChIP_OVARY_Human2.26260110
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20926378
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18436007
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.18299914
24RNF2_27304074_Chip-Seq_NSC_Mouse2.15374254
25FUS_26573619_Chip-Seq_HEK293_Human2.09489782
26SUZ12_27294783_Chip-Seq_NPCs_Mouse2.05847762
27KAP1_22055183_ChIP-Seq_ESCs_Mouse2.04942268
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02559493
29VDR_23849224_ChIP-Seq_CD4+_Human1.99213520
30ELK1_19687146_ChIP-ChIP_HELA_Human1.93727474
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.92585235
32MYC_18940864_ChIP-ChIP_HL60_Human1.92476641
33NFE2_27457419_Chip-Seq_LIVER_Mouse1.92124967
34NANOG_18555785_Chip-Seq_ESCs_Mouse1.87533473
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87034806
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.86913843
37TAF15_26573619_Chip-Seq_HEK293_Human1.86122289
38* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84342964
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.84049528
40EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79179316
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77865904
42ETS1_20019798_ChIP-Seq_JURKAT_Human1.76588629
43IGF1R_20145208_ChIP-Seq_DFB_Human1.76035008
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.72991189
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72132973
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.70803997
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.68460634
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66830522
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.66271628
50NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.65268093
51* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.64906181
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63322580
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63241975
54EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62213221
55ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.59053465
56SUZ12_18555785_Chip-Seq_ESCs_Mouse1.58902809
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.58681783
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58681783
59E2F1_18555785_Chip-Seq_ESCs_Mouse1.58649226
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57441774
61TP53_22573176_ChIP-Seq_HFKS_Human1.57225099
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.54542695
63CMYC_18555785_Chip-Seq_ESCs_Mouse1.54508408
64P300_19829295_ChIP-Seq_ESCs_Human1.54479812
65FOXM1_23109430_ChIP-Seq_U2OS_Human1.53452826
66P53_22387025_ChIP-Seq_ESCs_Mouse1.53387135
67AR_21572438_ChIP-Seq_LNCaP_Human1.52776657
68* IRF1_19129219_ChIP-ChIP_H3396_Human1.52121265
69NMYC_18555785_Chip-Seq_ESCs_Mouse1.51046665
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.48752204
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48739102
72EWS_26573619_Chip-Seq_HEK293_Human1.48727920
73FOXP3_21729870_ChIP-Seq_TREG_Human1.47969972
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47865862
75SOX2_18555785_Chip-Seq_ESCs_Mouse1.45318742
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43891236
77ER_23166858_ChIP-Seq_MCF-7_Human1.43832647
78KLF4_18555785_Chip-Seq_ESCs_Mouse1.43588649
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.43399111
80P300_18555785_Chip-Seq_ESCs_Mouse1.42309545
81SMAD4_21799915_ChIP-Seq_A2780_Human1.41436644
82RUNX1_27457419_Chip-Seq_LIVER_Mouse1.41326433
83ZFX_18555785_Chip-Seq_ESCs_Mouse1.40550878
84CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40216741
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.39155192
86CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.37712663
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37329611
88LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37136227
89ESRRB_18555785_Chip-Seq_ESCs_Mouse1.36946116
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.36393360
91KDM2B_26808549_Chip-Seq_REH_Human1.34991801
92MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.34327937
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.33870585
94STAT3_23295773_ChIP-Seq_U87_Human1.33556456
95* FOXA1_25329375_ChIP-Seq_VCAP_Human1.32099693
96* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32099693
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31141947
98CTCF_18555785_Chip-Seq_ESCs_Mouse1.30505925
99NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30304690
100KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.27955931
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.26872219
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26854675
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25788833
104UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25575643
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24157720
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.23983811
107CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23845275
108CBP_20019798_ChIP-Seq_JUKART_Human1.23617195
109IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23617195
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.22461665
111PU1_27457419_Chip-Seq_LIVER_Mouse1.22150155
112BCAT_22108803_ChIP-Seq_LS180_Human1.20413130
113SMAD1_18555785_Chip-Seq_ESCs_Mouse1.20264382
114TCF4_23295773_ChIP-Seq_U87_Human1.18460624
115OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17533029
116POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17390769
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16113446
118STAT1_17558387_ChIP-Seq_HELA_Human1.15986086
119RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15835923
120HTT_18923047_ChIP-ChIP_STHdh_Human1.15420135
121AR_20517297_ChIP-Seq_VCAP_Human1.14473416
122PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14319780
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12558079
124SMAD3_21741376_ChIP-Seq_EPCs_Human1.12124949
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12093217
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.11530366
127SOX2_19829295_ChIP-Seq_ESCs_Human1.10056927
128NANOG_19829295_ChIP-Seq_ESCs_Human1.10056927
129NCOR_22424771_ChIP-Seq_293T_Human1.09945144
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09598924
131* GATA3_21878914_ChIP-Seq_MCF-7_Human1.09102291
132SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07428764
133HOXB7_26014856_ChIP-Seq_BT474_Human1.07364629
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04498883
135PRDM14_20953172_ChIP-Seq_ESCs_Human1.04298956
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03428303
137AR_25329375_ChIP-Seq_VCAP_Human1.03221176
138FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02283722
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02155749
140GF1B_26923725_Chip-Seq_HPCs_Mouse1.02067175
141E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01963042
142RUNX1_26923725_Chip-Seq_HPCs_Mouse1.01629680
143RUNX2_22187159_ChIP-Seq_PCA_Human1.00576908
144TBL1_22424771_ChIP-Seq_293T_Human1.00330726
145TCF4_22108803_ChIP-Seq_LS180_Human1.00302947
146GABP_19822575_ChIP-Seq_HepG2_Human0.98498061
147ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96534166
148CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96445236
149FOXH1_21741376_ChIP-Seq_EPCs_Human0.93361698
150PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92791000
151E2F1_21310950_ChIP-Seq_MCF-7_Human0.90365449
152SMAD4_21741376_ChIP-Seq_EPCs_Human0.88779847

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect4.21468303
2MP0005451_abnormal_body_composition4.10672192
3MP0002102_abnormal_ear_morphology3.93087845
4MP0006292_abnormal_olfactory_placode3.64372972
5MP0008877_abnormal_DNA_methylation3.56881483
6MP0005410_abnormal_fertilization2.98158543
7MP0003787_abnormal_imprinting2.76093323
8MP0003136_yellow_coat_color2.74463461
9MP0003880_abnormal_central_pattern2.55930611
10MP0001929_abnormal_gametogenesis2.55560315
11MP0002653_abnormal_ependyma_morphology2.49825049
12MP0000566_synostosis2.38926480
13MP0005646_abnormal_pituitary_gland2.35439684
14MP0010094_abnormal_chromosome_stability2.33709272
15MP0003646_muscle_fatigue2.33561006
16MP0003195_calcinosis2.27512641
17MP0002210_abnormal_sex_determination2.18019629
18MP0001188_hyperpigmentation2.11813526
19MP0003693_abnormal_embryo_hatching2.07177192
20MP0003698_abnormal_male_reproductive1.98925436
21MP0001119_abnormal_female_reproductive1.98165057
22MP0000653_abnormal_sex_gland1.96610876
23MP0001529_abnormal_vocalization1.96518852
24MP0002876_abnormal_thyroid_physiology1.87382620
25MP0005395_other_phenotype1.87071975
26MP0008057_abnormal_DNA_replication1.86588960
27MP0003111_abnormal_nucleus_morphology1.83436655
28MP0000569_abnormal_digit_pigmentation1.82936485
29MP0001986_abnormal_taste_sensitivity1.76671927
30MP0004147_increased_porphyrin_level1.76305633
31MP0008058_abnormal_DNA_repair1.71456026
32MP0003121_genomic_imprinting1.68736885
33MP0003950_abnormal_plasma_membrane1.66064489
34MP0003699_abnormal_female_reproductive1.64982707
35MP0000372_irregular_coat_pigmentation1.61949208
36MP0002161_abnormal_fertility/fecundity1.56798362
37MP0002249_abnormal_larynx_morphology1.56352985
38MP0005409_darkened_coat_color1.55550169
39MP0001145_abnormal_male_reproductive1.53763529
40MP0008875_abnormal_xenobiotic_pharmacok1.51468938
41MP0006276_abnormal_autonomic_nervous1.50483201
42MP0010386_abnormal_urinary_bladder1.49603440
43MP0005408_hypopigmentation1.48821611
44MP0002837_dystrophic_cardiac_calcinosis1.48012389
45MP0002163_abnormal_gland_morphology1.47950485
46MP0003077_abnormal_cell_cycle1.43096988
47MP0001905_abnormal_dopamine_level1.42648734
48MP0002638_abnormal_pupillary_reflex1.42407747
49MP0008007_abnormal_cellular_replicative1.42263024
50MP0009697_abnormal_copulation1.40802647
51MP0009046_muscle_twitch1.39251869
52MP0002234_abnormal_pharynx_morphology1.36788251
53MP0003937_abnormal_limbs/digits/tail_de1.34933655
54MP0004142_abnormal_muscle_tone1.31373719
55MP0001968_abnormal_touch/_nociception1.31054975
56MP0005379_endocrine/exocrine_gland_phen1.29674265
57MP0008872_abnormal_physiological_respon1.29559750
58MP0004381_abnormal_hair_follicle1.27788943
59MP0009745_abnormal_behavioral_response1.27686954
60MP0008789_abnormal_olfactory_epithelium1.27683862
61MP0002272_abnormal_nervous_system1.26712311
62MP0001486_abnormal_startle_reflex1.25461368
63MP0008260_abnormal_autophagy1.24224038
64MP0000579_abnormal_nail_morphology1.20675818
65MP0003011_delayed_dark_adaptation1.20598795
66MP0000015_abnormal_ear_pigmentation1.18748584
67MP0001346_abnormal_lacrimal_gland1.17836598
68MP0002138_abnormal_hepatobiliary_system1.17632315
69MP0003567_abnormal_fetal_cardiomyocyte1.17164218
70MP0005171_absent_coat_pigmentation1.11878613
71MP0002928_abnormal_bile_duct1.09045020
72MP0008932_abnormal_embryonic_tissue1.08205164
73MP0005084_abnormal_gallbladder_morpholo1.08145588
74MP0006072_abnormal_retinal_apoptosis1.06826230
75MP0000026_abnormal_inner_ear1.06807228
76MP0002095_abnormal_skin_pigmentation1.06664853
77MP0005174_abnormal_tail_pigmentation1.06586028
78MP0004133_heterotaxia1.05467225
79MP0000631_abnormal_neuroendocrine_gland1.05216456
80MP0001293_anophthalmia1.01121374
81MP0003890_abnormal_embryonic-extraembry1.00753991
82MP0001501_abnormal_sleep_pattern0.99491597
83MP0002734_abnormal_mechanical_nocicepti0.99023930
84MP0005195_abnormal_posterior_eye0.98865829
85MP0003755_abnormal_palate_morphology0.98255764
86MP0009250_abnormal_appendicular_skeleto0.98023737
87MP0003941_abnormal_skin_development0.97371876
88MP0001984_abnormal_olfaction0.97193895
89MP0005423_abnormal_somatic_nervous0.96220730
90MP0004782_abnormal_surfactant_physiolog0.95602238
91MP0004742_abnormal_vestibular_system0.95534711
92MP0000778_abnormal_nervous_system0.95494487
93MP0001502_abnormal_circadian_rhythm0.94489645
94MP0005647_abnormal_sex_gland0.91920319
95MP0000462_abnormal_digestive_system0.91496178
96MP0000427_abnormal_hair_cycle0.90921470
97MP0004043_abnormal_pH_regulation0.90468094
98MP0003938_abnormal_ear_development0.90050409
99MP0004270_analgesia0.89318554
100MP0002177_abnormal_outer_ear0.88694232
101MP0003786_premature_aging0.87999468
102MP0005551_abnormal_eye_electrophysiolog0.87561951
103MP0001764_abnormal_homeostasis0.86420152
104MP0002277_abnormal_respiratory_mucosa0.85356774
105MP0001963_abnormal_hearing_physiology0.83186194
106MP0005394_taste/olfaction_phenotype0.83091607
107MP0005499_abnormal_olfactory_system0.83091607
108MP0003186_abnormal_redox_activity0.82976717
109MP0003119_abnormal_digestive_system0.82357576
110MP0005389_reproductive_system_phenotype0.81826266
111MP0006035_abnormal_mitochondrial_morpho0.80109494
112MP0002752_abnormal_somatic_nervous0.79709243
113MP0002736_abnormal_nociception_after0.78474077
114MP0001485_abnormal_pinna_reflex0.78388425
115MP0004957_abnormal_blastocyst_morpholog0.78088823
116MP0002572_abnormal_emotion/affect_behav0.77658494
117MP0010307_abnormal_tumor_latency0.77636370
118MP0005391_vision/eye_phenotype0.77237394
119MP0008995_early_reproductive_senescence0.77162825
120MP0005085_abnormal_gallbladder_physiolo0.77040954
121MP0005310_abnormal_salivary_gland0.76958093
122MP0005253_abnormal_eye_physiology0.76812547
123MP0004019_abnormal_vitamin_homeostasis0.76528256
124MP0006036_abnormal_mitochondrial_physio0.73847808
125MP0003943_abnormal_hepatobiliary_system0.73468762
126MP0000049_abnormal_middle_ear0.72472213
127MP0005075_abnormal_melanosome_morpholog0.72057952
128MP0001851_eye_inflammation0.71190617
129MP0002938_white_spotting0.70947851
130MP0003315_abnormal_perineum_morphology0.70102655
131MP0000383_abnormal_hair_follicle0.69462781
132MP0002116_abnormal_craniofacial_bone0.68502140
133MP0002557_abnormal_social/conspecific_i0.67976170
134MP0002160_abnormal_reproductive_system0.67458418
135MP0003861_abnormal_nervous_system0.64373447
136MP0001919_abnormal_reproductive_system0.63759954
137MP0002233_abnormal_nose_morphology0.63054368
138MP0002735_abnormal_chemical_nociception0.62119218
139MP0000678_abnormal_parathyroid_gland0.61919629
140MP0005645_abnormal_hypothalamus_physiol0.61083091

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.08021889
2Abnormal respiratory motile cilium physiology (HP:0012261)6.02917206
3Dynein arm defect of respiratory motile cilia (HP:0012255)5.53255964
4Absent/shortened dynein arms (HP:0200106)5.53255964
5Abnormal ciliary motility (HP:0012262)5.30512456
6Chromosomal breakage induced by crosslinking agents (HP:0003221)5.19568834
7Chromsome breakage (HP:0040012)4.99312530
8Abnormal respiratory motile cilium morphology (HP:0005938)4.88097472
9Abnormal respiratory epithelium morphology (HP:0012253)4.88097472
10Rhinitis (HP:0012384)4.69193960
11Male infertility (HP:0003251)3.73347767
12Chronic bronchitis (HP:0004469)3.39817446
13Congenital stationary night blindness (HP:0007642)3.34341110
14Nephronophthisis (HP:0000090)3.18149239
15Pendular nystagmus (HP:0012043)3.13187412
16Duplicated collecting system (HP:0000081)3.11436218
17Adrenal hypoplasia (HP:0000835)3.02826926
18Prostate neoplasm (HP:0100787)3.02784470
19Birth length less than 3rd percentile (HP:0003561)3.01406802
20Infertility (HP:0000789)2.96218655
21Abnormality of the renal collecting system (HP:0004742)2.94252227
22Pancreatic fibrosis (HP:0100732)2.91051668
23Bronchiectasis (HP:0002110)2.85738020
24Type II lissencephaly (HP:0007260)2.84606633
25Abnormality of the renal cortex (HP:0011035)2.82695809
26Medial flaring of the eyebrow (HP:0010747)2.79984059
27Breast hypoplasia (HP:0003187)2.68051044
28Abnormality of the renal medulla (HP:0100957)2.67007038
29Aplasia/Hypoplasia of the uvula (HP:0010293)2.65644579
30True hermaphroditism (HP:0010459)2.64697247
31Abnormality of chromosome stability (HP:0003220)2.64218355
32Supernumerary spleens (HP:0009799)2.61220420
33Abnormality of midbrain morphology (HP:0002418)2.59457156
34Molar tooth sign on MRI (HP:0002419)2.59457156
35Renal cortical cysts (HP:0000803)2.56966027
36Gait imbalance (HP:0002141)2.55911031
37Abnormality of the preputium (HP:0100587)2.54459249
38Papillary thyroid carcinoma (HP:0002895)2.53048000
39Colon cancer (HP:0003003)2.52640923
40Congenital primary aphakia (HP:0007707)2.48676841
41Acute necrotizing encephalopathy (HP:0006965)2.47688437
42Absent thumb (HP:0009777)2.47478649
43Ectopic kidney (HP:0000086)2.46888466
44Tubular atrophy (HP:0000092)2.41768615
45Abnormality of alanine metabolism (HP:0010916)2.41014224
46Hyperalaninemia (HP:0003348)2.41014224
47Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41014224
48Oligodactyly (hands) (HP:0001180)2.40339242
49Meckel diverticulum (HP:0002245)2.40169791
50Pancreatic cysts (HP:0001737)2.39700927
51Attenuation of retinal blood vessels (HP:0007843)2.39663201
52Nephrogenic diabetes insipidus (HP:0009806)2.38747937
53Increased CSF lactate (HP:0002490)2.37741785
54Clubbing of toes (HP:0100760)2.37411622
55Chronic hepatic failure (HP:0100626)2.33629295
56Polydipsia (HP:0001959)2.31089635
57Abnormal drinking behavior (HP:0030082)2.31089635
58Hypoplasia of the fovea (HP:0007750)2.29662056
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.29662056
60Mitochondrial inheritance (HP:0001427)2.28826216
61Acute encephalopathy (HP:0006846)2.28638901
62Flat capital femoral epiphysis (HP:0003370)2.27367279
63Poor coordination (HP:0002370)2.27137609
64Cystic liver disease (HP:0006706)2.27076840
65Abnormality of the ileum (HP:0001549)2.23986439
66Progressive macrocephaly (HP:0004481)2.23159313
67Atelectasis (HP:0100750)2.22736809
68Gaze-evoked nystagmus (HP:0000640)2.21146751
69Hypergonadotropic hypogonadism (HP:0000815)2.19658669
70Abnormal biliary tract physiology (HP:0012439)2.18004465
71Bile duct proliferation (HP:0001408)2.18004465
72Nephroblastoma (Wilms tumor) (HP:0002667)2.17432503
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.15610500
74Sclerocornea (HP:0000647)2.15364520
75Volvulus (HP:0002580)2.14076980
76Hepatic necrosis (HP:0002605)2.14026302
77Abnormality of the fovea (HP:0000493)2.13137873
78Abnormal mitochondria in muscle tissue (HP:0008316)2.11660018
79Male pseudohermaphroditism (HP:0000037)2.09478034
80Patellar aplasia (HP:0006443)2.09044425
81Cerebellar dysplasia (HP:0007033)2.07220688
82Abnormal hair whorl (HP:0010721)2.06621745
83Embryonal renal neoplasm (HP:0011794)2.06490352
84Abnormality of the labia minora (HP:0012880)2.06454312
85Genital tract atresia (HP:0001827)2.04513852
86Lip pit (HP:0100267)2.02770935
87Hepatocellular necrosis (HP:0001404)2.02527945
88Hypothermia (HP:0002045)2.00297459
89Abnormal rod and cone electroretinograms (HP:0008323)1.99188860
90Vaginal atresia (HP:0000148)1.98646332
91Short tibia (HP:0005736)1.98404709
92Abolished electroretinogram (ERG) (HP:0000550)1.98025859
93Hypoplasia of the pons (HP:0012110)1.97049198
94Methylmalonic acidemia (HP:0002912)1.96057903
95Facial hemangioma (HP:0000329)1.95756529
96Anomalous pulmonary venous return (HP:0010772)1.95477546
97Abnormality of the pons (HP:0007361)1.94867270
98Lissencephaly (HP:0001339)1.94814286
99Increased hepatocellular lipid droplets (HP:0006565)1.94569127
100Occipital encephalocele (HP:0002085)1.94085863
101Fetal akinesia sequence (HP:0001989)1.93812936
102Postaxial foot polydactyly (HP:0001830)1.93391533
103Aganglionic megacolon (HP:0002251)1.92567013
104Abnormality of the duodenum (HP:0002246)1.92479936
105Hyperglycinemia (HP:0002154)1.91876440
106Dandy-Walker malformation (HP:0001305)1.90996592
107Anencephaly (HP:0002323)1.89861548
108Reticulocytopenia (HP:0001896)1.89388076
109Congenital, generalized hypertrichosis (HP:0004540)1.89320854
110Lipid accumulation in hepatocytes (HP:0006561)1.88979012
111Increased serum lactate (HP:0002151)1.88043407
112Absent septum pellucidum (HP:0001331)1.87452079
113Optic neuritis (HP:0100653)1.86887989
114Retrobulbar optic neuritis (HP:0100654)1.86887989
115Aplasia/Hypoplasia of the patella (HP:0006498)1.86676651
116Small intestinal stenosis (HP:0012848)1.85183336
117Duodenal stenosis (HP:0100867)1.85183336
118Median cleft lip (HP:0000161)1.83918762
119Tubulointerstitial nephritis (HP:0001970)1.83536990
120Progressive inability to walk (HP:0002505)1.83240903
121Azoospermia (HP:0000027)1.82239479
122Aplasia/Hypoplasia of the breasts (HP:0010311)1.82179930
123Sloping forehead (HP:0000340)1.82058231
124Retinal dysplasia (HP:0007973)1.80071044
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.79106522
126Breast aplasia (HP:0100783)1.78244743
1273-Methylglutaconic aciduria (HP:0003535)1.77159444
128Severe muscular hypotonia (HP:0006829)1.77136247
129Astigmatism (HP:0000483)1.76447472
130Fair hair (HP:0002286)1.76422050
131Abnormality of DNA repair (HP:0003254)1.76274881
132Chorioretinal atrophy (HP:0000533)1.75065149
133Aplasia/Hypoplasia of the lens (HP:0008063)1.74762044
134Inability to walk (HP:0002540)1.74718980
135Septo-optic dysplasia (HP:0100842)1.74678755
136Aplasia/Hypoplasia of the earlobes (HP:0009906)1.74334539
137Acute myeloid leukemia (HP:0004808)1.74118641
138Bony spicule pigmentary retinopathy (HP:0007737)1.73448191
139Optic disc pallor (HP:0000543)1.72699046
140Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70473874
141Degeneration of the lateral corticospinal tracts (HP:0002314)1.70473874
142Preaxial hand polydactyly (HP:0001177)1.70165947
143Abnormality of the septum pellucidum (HP:0007375)1.69124777
144Abnormality of the carotid arteries (HP:0005344)1.67652565
145Congenital sensorineural hearing impairment (HP:0008527)1.66929730
146Parakeratosis (HP:0001036)1.66603262
147Oligohydramnios (HP:0001562)1.66244621
148Short thumb (HP:0009778)1.64114951
149White forelock (HP:0002211)1.63985891
150Type 2 muscle fiber atrophy (HP:0003554)1.63591643
151Shawl scrotum (HP:0000049)1.61475219
152Nonprogressive disorder (HP:0003680)1.60343137
153Abnormality of the prostate (HP:0008775)1.60336313
154Congenital hepatic fibrosis (HP:0002612)1.59915911
155Abnormality of the dental pulp (HP:0006479)1.59281971
156Impulsivity (HP:0100710)1.58979439
157Capillary hemangiomas (HP:0005306)1.58627156
158Abnormality of the pulmonary veins (HP:0011718)1.58201496
159Abnormality of molar (HP:0011077)1.57986897

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.56224003
2BMPR23.94086121
3LATS13.22594334
4PLK43.16876048
5TAOK32.96751928
6MOS2.85072053
7TTK2.73997093
8STK38L2.71565159
9MUSK2.61064313
10MAP3K62.37135575
11BMPR1B2.26189003
12BRSK22.26188477
13BUB12.26089545
14WNK42.24239316
15NEK12.23596899
16CASK2.18420219
17BRAF2.05571254
18VRK22.01389575
19TLK12.00825855
20CDK81.94603464
21ERBB41.92315268
22LATS21.91360482
23MAPK131.87481872
24CDC71.86364060
25TNIK1.81643614
26MAP4K21.80059296
27ACVR1B1.69491103
28NLK1.66783817
29WEE11.56022667
30DYRK21.55744980
31STK31.47310122
32MAP2K71.45507847
33CHEK21.42695229
34CDK31.38451352
35TRIM281.36339725
36TAF11.34936799
37NEK61.34113113
38PBK1.33583303
39MELK1.32578733
40BCKDK1.29561229
41EPHA41.26835266
42MAP3K91.24807665
43CDK91.23099355
44NUAK11.21500957
45MAPKAPK51.18086373
46ZAK1.08138469
47EIF2AK31.07432654
48BCR1.07183781
49PLK11.06734904
50STK161.04721148
51MST41.04237553
52PDK41.02746554
53PDK31.02746554
54PRKCI1.00872076
55TSSK61.00837461
56MAP3K131.00535352
57BRSK10.99045372
58VRK10.96267501
59PRKD30.94720662
60RAF10.87487913
61MKNK20.84798233
62WNK30.84695216
63MAP3K40.83521288
64CSNK1G10.82609716
65MARK30.82363772
66ARAF0.81731170
67CLK10.81638310
68MKNK10.81160942
69STK390.80990478
70STK100.77613027
71EIF2AK20.77527140
72PHKG20.77079413
73PHKG10.77079413
74STK240.76021357
75SRPK10.75186996
76TGFBR10.74466721
77NTRK20.74449321
78PAK60.74236598
79CAMKK20.74141640
80PRKD20.72625285
81TRPM70.70610189
82CSNK1G30.70405139
83PRKCG0.70322692
84GRK70.69719540
85PAK30.69413071
86IRAK40.68992920
87PKN10.68528474
88KSR20.66437541
89CSNK1A1L0.65005666
90ADRBK10.64182627
91MAPK150.63798914
92GRK10.63058156
93TNK20.62973491
94ATM0.61392127
95CDK190.60766304
96SGK20.60104047
97PLK30.59844327
98TIE10.58997829
99PDK20.58182782
100PINK10.56410770
101PRKCE0.56233094
102PTK2B0.55698754
103PLK20.55560468
104PNCK0.55481839
105EPHA30.54863073
106TXK0.54691965
107SGK4940.54196774
108SGK2230.54196774
109RPS6KA50.53276102
110OXSR10.52906415
111KSR10.52498187
112AURKA0.51446670
113PRPF4B0.50341296
114EIF2AK10.49952729
115STK380.49854317
116NTRK30.46754462
117IRAK10.46713015
118MAPKAPK30.46497685
119CSNK1G20.45320473
120AKT30.45250256
121CSNK2A10.45055989
122NME10.44663834
123CSNK1D0.44596551
124NEK20.44030735
125MARK20.43763005
126CHEK10.43013142
127* CAMK2A0.42820123
128CDK70.42489489
129ATR0.41104107
130FGFR20.39789766
131CCNB10.39484225
132MAP3K140.38834059
133AURKB0.38551165
134ADRBK20.37974496
135ABL20.37194912
136PASK0.37143764
137MARK10.37098299
138PRKAA20.36183134
139PRKACA0.35778614
140INSRR0.34970808
141ERBB30.34720676
142YES10.34637710
143CSNK2A20.34584201
144IRAK30.34398291

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal transcription factors_Homo sapiens_hsa030223.56429464
2Fanconi anemia pathway_Homo sapiens_hsa034603.45025516
3Vitamin B6 metabolism_Homo sapiens_hsa007503.05214454
4Ether lipid metabolism_Homo sapiens_hsa005652.87065973
5Ovarian steroidogenesis_Homo sapiens_hsa049132.73643962
6RNA degradation_Homo sapiens_hsa030182.67660600
7Protein export_Homo sapiens_hsa030602.63693251
8Linoleic acid metabolism_Homo sapiens_hsa005912.55811938
9Cell cycle_Homo sapiens_hsa041102.43754622
10Oxidative phosphorylation_Homo sapiens_hsa001902.40395767
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.39512377
12Homologous recombination_Homo sapiens_hsa034402.33223265
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23412317
14Non-homologous end-joining_Homo sapiens_hsa034502.18658331
15Circadian rhythm_Homo sapiens_hsa047102.14960945
16Parkinsons disease_Homo sapiens_hsa050122.09587261
17Butanoate metabolism_Homo sapiens_hsa006502.02604852
18Proteasome_Homo sapiens_hsa030501.96028866
19One carbon pool by folate_Homo sapiens_hsa006701.90586849
20RNA polymerase_Homo sapiens_hsa030201.89211124
21Selenocompound metabolism_Homo sapiens_hsa004501.84463029
22Nicotine addiction_Homo sapiens_hsa050331.81794378
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.73501301
24Nitrogen metabolism_Homo sapiens_hsa009101.69508017
25Arachidonic acid metabolism_Homo sapiens_hsa005901.60037345
26Propanoate metabolism_Homo sapiens_hsa006401.54579033
27Sphingolipid metabolism_Homo sapiens_hsa006001.53437738
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.51634754
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46415300
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.45897356
31Dorso-ventral axis formation_Homo sapiens_hsa043201.32991646
32Caffeine metabolism_Homo sapiens_hsa002321.30551505
33Serotonergic synapse_Homo sapiens_hsa047261.30146361
34Sulfur relay system_Homo sapiens_hsa041221.28286960
35Nucleotide excision repair_Homo sapiens_hsa034201.27572449
36Ribosome_Homo sapiens_hsa030101.27489679
37Phototransduction_Homo sapiens_hsa047441.25720269
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25505328
39p53 signaling pathway_Homo sapiens_hsa041151.25471608
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24052123
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16380052
42Tryptophan metabolism_Homo sapiens_hsa003801.14296285
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14207916
44Alzheimers disease_Homo sapiens_hsa050101.11647525
45Purine metabolism_Homo sapiens_hsa002301.09901161
46Autoimmune thyroid disease_Homo sapiens_hsa053201.09290014
47Pyrimidine metabolism_Homo sapiens_hsa002401.08651957
48Base excision repair_Homo sapiens_hsa034101.08317577
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.03226200
50* Oocyte meiosis_Homo sapiens_hsa041141.00421685
51Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.99498739
52mRNA surveillance pathway_Homo sapiens_hsa030150.97055107
53TGF-beta signaling pathway_Homo sapiens_hsa043500.96625327
54Glutamatergic synapse_Homo sapiens_hsa047240.96541262
55Cardiac muscle contraction_Homo sapiens_hsa042600.95776008
56Peroxisome_Homo sapiens_hsa041460.95188195
57Long-term depression_Homo sapiens_hsa047300.95175974
58Graft-versus-host disease_Homo sapiens_hsa053320.93968496
59RNA transport_Homo sapiens_hsa030130.93451461
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.92721826
61Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91971847
62Mismatch repair_Homo sapiens_hsa034300.91622448
63Choline metabolism in cancer_Homo sapiens_hsa052310.90363511
64Regulation of autophagy_Homo sapiens_hsa041400.90104036
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89228516
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88664839
67Taste transduction_Homo sapiens_hsa047420.87969375
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.87572218
69Olfactory transduction_Homo sapiens_hsa047400.87153967
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.80614891
71Allograft rejection_Homo sapiens_hsa053300.80126013
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80092889
73Axon guidance_Homo sapiens_hsa043600.77291684
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.74642078
75Rheumatoid arthritis_Homo sapiens_hsa053230.73595762
76Sulfur metabolism_Homo sapiens_hsa009200.72910587
77Huntingtons disease_Homo sapiens_hsa050160.71306847
78Morphine addiction_Homo sapiens_hsa050320.70610919
79Pancreatic cancer_Homo sapiens_hsa052120.70578226
80Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70551007
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70550593
82Fatty acid elongation_Homo sapiens_hsa000620.70388070
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69881432
84Metabolic pathways_Homo sapiens_hsa011000.69447539
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69221496
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69128350
87Ras signaling pathway_Homo sapiens_hsa040140.68692942
88Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67125600
89DNA replication_Homo sapiens_hsa030300.66560737
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.66047450
91Wnt signaling pathway_Homo sapiens_hsa043100.65088186
92Folate biosynthesis_Homo sapiens_hsa007900.64502169
93NF-kappa B signaling pathway_Homo sapiens_hsa040640.63864336
94Herpes simplex infection_Homo sapiens_hsa051680.63689392
95ABC transporters_Homo sapiens_hsa020100.63455730
96Primary immunodeficiency_Homo sapiens_hsa053400.62006546
97Steroid biosynthesis_Homo sapiens_hsa001000.61896647
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59786593
99Chemical carcinogenesis_Homo sapiens_hsa052040.57251295
100NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57243836
101MicroRNAs in cancer_Homo sapiens_hsa052060.57082394
102Cocaine addiction_Homo sapiens_hsa050300.56606032
103beta-Alanine metabolism_Homo sapiens_hsa004100.55460244
104GnRH signaling pathway_Homo sapiens_hsa049120.54122133
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53963355
106Asthma_Homo sapiens_hsa053100.53537049
107Prolactin signaling pathway_Homo sapiens_hsa049170.52529450
108Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.52482622
109Other glycan degradation_Homo sapiens_hsa005110.51393824
110Intestinal immune network for IgA production_Homo sapiens_hsa046720.51081953
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51031189
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49384010
113Hematopoietic cell lineage_Homo sapiens_hsa046400.47164195
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46767797
115Colorectal cancer_Homo sapiens_hsa052100.45743790
116Vascular smooth muscle contraction_Homo sapiens_hsa042700.45654080
117cAMP signaling pathway_Homo sapiens_hsa040240.45068909
118Notch signaling pathway_Homo sapiens_hsa043300.44567205
119Basal cell carcinoma_Homo sapiens_hsa052170.44309197
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42901910
121MAPK signaling pathway_Homo sapiens_hsa040100.42789802
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.40795085
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38935610
124Hippo signaling pathway_Homo sapiens_hsa043900.38069701
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.37320928
126Pyruvate metabolism_Homo sapiens_hsa006200.36836201
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36710973
128GABAergic synapse_Homo sapiens_hsa047270.35816473
129Malaria_Homo sapiens_hsa051440.35681237
130Measles_Homo sapiens_hsa051620.35337554
131Fat digestion and absorption_Homo sapiens_hsa049750.35330110
132FoxO signaling pathway_Homo sapiens_hsa040680.35131047
133Collecting duct acid secretion_Homo sapiens_hsa049660.35008554
134Lysine degradation_Homo sapiens_hsa003100.34453583
135ErbB signaling pathway_Homo sapiens_hsa040120.34263067
136Hedgehog signaling pathway_Homo sapiens_hsa043400.33827229
137Retinol metabolism_Homo sapiens_hsa008300.33621848
138Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32248253
139Insulin secretion_Homo sapiens_hsa049110.32176698
140Amphetamine addiction_Homo sapiens_hsa050310.32066396
141Phospholipase D signaling pathway_Homo sapiens_hsa040720.31898309
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.31845178
143Type I diabetes mellitus_Homo sapiens_hsa049400.30546182
144Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28868359
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.27085000
146Spliceosome_Homo sapiens_hsa030400.26625827
147Vitamin digestion and absorption_Homo sapiens_hsa049770.25867994
148Inositol phosphate metabolism_Homo sapiens_hsa005620.25689889
149Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24518890
150Circadian entrainment_Homo sapiens_hsa047130.21655431

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