FBXO45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)5.76042242
2nuclear pore complex assembly (GO:0051292)5.52653462
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51427037
4mitotic chromosome condensation (GO:0007076)5.15501755
5regulation of synaptic vesicle exocytosis (GO:2000300)5.11811951
6nuclear pore organization (GO:0006999)5.05090006
7synaptic vesicle maturation (GO:0016188)4.94595143
8synaptic vesicle exocytosis (GO:0016079)4.78345562
9locomotory exploration behavior (GO:0035641)4.77080747
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.75717860
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72326263
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.64141986
13glutamate secretion (GO:0014047)4.61400888
14vocalization behavior (GO:0071625)4.59165434
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.59155770
16regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.52803160
17regulation of synaptic vesicle transport (GO:1902803)4.49546052
18layer formation in cerebral cortex (GO:0021819)4.47272790
19synapsis (GO:0007129)4.45113380
20mitotic metaphase plate congression (GO:0007080)4.36623015
21protein localization to synapse (GO:0035418)4.32699379
22neuron cell-cell adhesion (GO:0007158)4.32529634
23regulation of DNA endoreduplication (GO:0032875)4.31302785
24regulation of glutamate receptor signaling pathway (GO:1900449)4.29471731
25dendritic spine morphogenesis (GO:0060997)4.29451073
26ionotropic glutamate receptor signaling pathway (GO:0035235)4.28336694
27DNA unwinding involved in DNA replication (GO:0006268)4.25951443
28protein localization to chromosome, centromeric region (GO:0071459)4.16558769
29DNA replication checkpoint (GO:0000076)4.16152876
30protein localization to kinetochore (GO:0034501)4.15076329
31sister chromatid segregation (GO:0000819)4.11933587
32mitotic sister chromatid segregation (GO:0000070)4.10405334
33neuron recognition (GO:0008038)4.06364099
34sister chromatid cohesion (GO:0007062)4.00423325
35neuronal action potential propagation (GO:0019227)3.99243883
36regulation of centriole replication (GO:0046599)3.97469265
37axonal fasciculation (GO:0007413)3.97194879
38exploration behavior (GO:0035640)3.95669169
39regulation of synapse structural plasticity (GO:0051823)3.92606522
40pore complex assembly (GO:0046931)3.92577373
41metaphase plate congression (GO:0051310)3.92562783
42glutamate receptor signaling pathway (GO:0007215)3.92086599
43positive regulation of synapse maturation (GO:0090129)3.89767141
44meiotic chromosome segregation (GO:0045132)3.88206674
45regulation of long-term neuronal synaptic plasticity (GO:0048169)3.82397671
46neurotransmitter secretion (GO:0007269)3.81498356
47regulation of meiosis I (GO:0060631)3.80441725
48CENP-A containing nucleosome assembly (GO:0034080)3.77014981
49chromatin remodeling at centromere (GO:0031055)3.74024126
50regulation of neuronal synaptic plasticity (GO:0048168)3.69167159
51kinetochore organization (GO:0051383)3.68953010
52ribosome assembly (GO:0042255)3.61489034
53positive regulation of chromosome segregation (GO:0051984)3.61143191
54DNA strand elongation involved in DNA replication (GO:0006271)3.60421774
55synaptic transmission, glutamatergic (GO:0035249)3.56624498
56resolution of meiotic recombination intermediates (GO:0000712)3.56417849
57chromosome organization involved in meiosis (GO:0070192)3.53311390
58establishment of chromosome localization (GO:0051303)3.52102165
59vesicle transport along microtubule (GO:0047496)3.51795328
60DNA strand elongation (GO:0022616)3.50836216
61regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.49715087
62cerebellar granule cell differentiation (GO:0021707)3.49086240
63activation of protein kinase A activity (GO:0034199)3.47768461
64cell migration in hindbrain (GO:0021535)3.46630864
65neuron-neuron synaptic transmission (GO:0007270)3.46524121
66regulation of dendritic spine morphogenesis (GO:0061001)3.45332892
67proline transport (GO:0015824)3.44567107
68regulation of centrosome cycle (GO:0046605)3.43260890
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.40921077
70positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.40921077
71positive regulation of mitotic sister chromatid separation (GO:1901970)3.40921077
72protein localization to chromosome (GO:0034502)3.39515909
73mitotic nuclear envelope disassembly (GO:0007077)3.37303196
74long-term memory (GO:0007616)3.34925172
75formation of translation preinitiation complex (GO:0001731)3.32203200
76DNA synthesis involved in DNA repair (GO:0000731)3.31451853
77DNA replication initiation (GO:0006270)3.29370374
78regulation of cAMP-dependent protein kinase activity (GO:2000479)3.28278202
79histone exchange (GO:0043486)3.26811506
80nuclear envelope disassembly (GO:0051081)3.24778649
81membrane disassembly (GO:0030397)3.24778649
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24681685
83organelle transport along microtubule (GO:0072384)3.24634105
84gamma-aminobutyric acid transport (GO:0015812)3.23649990
85establishment of nucleus localization (GO:0040023)3.23397085
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20815971
87DNA topological change (GO:0006265)3.19764729
88* central nervous system projection neuron axonogenesis (GO:0021952)3.19418938
89cerebellar Purkinje cell differentiation (GO:0021702)3.18835147
90regulation of excitatory postsynaptic membrane potential (GO:0060079)3.17953924
91chromosome segregation (GO:0007059)3.17612520
92DNA replication-independent nucleosome assembly (GO:0006336)3.16205126
93DNA replication-independent nucleosome organization (GO:0034724)3.16205126
94dendrite morphogenesis (GO:0048813)3.13232358
95regulation of vesicle fusion (GO:0031338)3.12443436
96regulation of chromosome segregation (GO:0051983)3.12125750
97innervation (GO:0060384)3.10666702
98regulation of neurotransmitter secretion (GO:0046928)3.09672316
99gamma-aminobutyric acid signaling pathway (GO:0007214)3.09348008
100nerve growth factor signaling pathway (GO:0038180)3.08024208
101regulation of postsynaptic membrane potential (GO:0060078)3.07729983
102regulation of spindle organization (GO:0090224)3.07663123
103telomere maintenance via semi-conservative replication (GO:0032201)3.07274845
104establishment of integrated proviral latency (GO:0075713)3.07094649
105piRNA metabolic process (GO:0034587)3.03431654
106regulation of synaptic plasticity (GO:0048167)3.02772448
107regulation of clathrin-mediated endocytosis (GO:2000369)2.99299355
108neurotransmitter transport (GO:0006836)2.99221702
109* synapse assembly (GO:0007416)2.98987446
110regulation of dendritic spine development (GO:0060998)2.95038726
111neuromuscular process controlling balance (GO:0050885)2.94908725
112synaptic vesicle endocytosis (GO:0048488)2.94858232
113regulation of RNA export from nucleus (GO:0046831)2.94852941
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.93956789
115mating behavior (GO:0007617)2.92630238
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.92476742
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92476742
118neurotransmitter-gated ion channel clustering (GO:0072578)2.91335072
119protein K6-linked ubiquitination (GO:0085020)2.90924737
120G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.89436700
121presynaptic membrane assembly (GO:0097105)2.88967687
122DNA double-strand break processing (GO:0000729)2.88271028
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.86160809
124negative regulation of dendrite morphogenesis (GO:0050774)2.86128267
125regulation of synapse maturation (GO:0090128)2.84798418
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.84708673
127cellular potassium ion homeostasis (GO:0030007)2.84677430
128dendritic spine organization (GO:0097061)2.84651912
129regulation of translational fidelity (GO:0006450)2.84501403
130positive regulation of membrane potential (GO:0045838)2.84453192
131regulation of centrosome duplication (GO:0010824)2.83832741
132regulation of neurotransmitter transport (GO:0051588)2.83123803
133chromosome condensation (GO:0030261)2.83008819
134mitotic recombination (GO:0006312)2.82707665
135spindle checkpoint (GO:0031577)2.82142380
136negative regulation of dendrite development (GO:2000171)2.81910993
137membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81384725
138long-term synaptic potentiation (GO:0060291)2.81229145
139regulation of mitotic spindle organization (GO:0060236)2.81086772
140meiotic cell cycle process (GO:1903046)2.80230806
141kinetochore assembly (GO:0051382)2.79653118
142gonadal mesoderm development (GO:0007506)2.79449746
143negative regulation of microtubule polymerization (GO:0031115)2.79069981
144regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.78703224
145prepulse inhibition (GO:0060134)2.78517953
146DNA duplex unwinding (GO:0032508)2.78505516
147ribosome biogenesis (GO:0042254)2.78432060
148regulation of glycogen (starch) synthase activity (GO:2000465)2.76989461
149DNA catabolic process, exonucleolytic (GO:0000738)2.76974178
150spindle assembly involved in mitosis (GO:0090307)2.76089838
151* synapse organization (GO:0050808)2.75193738
152ATP-dependent chromatin remodeling (GO:0043044)2.74497554
153DNA geometric change (GO:0032392)2.74409579
154regulation of histone H3-K9 methylation (GO:0051570)2.74073176
155regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.73960995
156regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73960995
157membrane hyperpolarization (GO:0060081)2.72968162
158negative regulation of synaptic transmission, GABAergic (GO:0032229)2.72792299
159regulation of neurotransmitter levels (GO:0001505)2.72571054
160presynaptic membrane organization (GO:0097090)2.72506122
161non-recombinational repair (GO:0000726)2.71873597
162double-strand break repair via nonhomologous end joining (GO:0006303)2.71873597
163attachment of spindle microtubules to kinetochore (GO:0008608)2.71793756
164positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.70577782
165membrane depolarization (GO:0051899)2.70389567
166regulation of synaptic transmission, glutamatergic (GO:0051966)2.70005962
167DNA replication-dependent nucleosome organization (GO:0034723)2.69767457
168DNA replication-dependent nucleosome assembly (GO:0006335)2.69767457
169axon extension (GO:0048675)2.69542093
170regulation of sister chromatid segregation (GO:0033045)2.69535745
171regulation of mitotic sister chromatid separation (GO:0010965)2.69535745
172regulation of mitotic sister chromatid segregation (GO:0033047)2.69535745
173regulation of DNA-dependent DNA replication (GO:0090329)2.69182995
174nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.68373170
175membrane depolarization during action potential (GO:0086010)2.68108911
176learning (GO:0007612)2.67844660
177chromatin assembly or disassembly (GO:0006333)2.67707082
178postsynaptic membrane organization (GO:0001941)2.67609867
179mitotic spindle organization (GO:0007052)2.67560450
180DNA ligation (GO:0006266)2.67413803
181clathrin coat assembly (GO:0048268)2.67072950
182regulation of sister chromatid cohesion (GO:0007063)2.66639768
183mitotic spindle checkpoint (GO:0071174)2.65859790
184DNA conformation change (GO:0071103)2.65223283
185telomere maintenance via recombination (GO:0000722)2.64901210
186* cerebral cortex radially oriented cell migration (GO:0021799)2.64733550
187meiotic cell cycle (GO:0051321)2.63816759
188cerebellum development (GO:0021549)2.63493066
189replication fork processing (GO:0031297)2.62771753
190DNA packaging (GO:0006323)2.61905069
191gene silencing by RNA (GO:0031047)2.61597212
192negative regulation of chromosome segregation (GO:0051985)2.61485075
193neuronal ion channel clustering (GO:0045161)2.61337921
194transmission of nerve impulse (GO:0019226)2.61166730
195male meiosis I (GO:0007141)2.61059535
196regulation of DNA methylation (GO:0044030)2.60954476
197behavioral fear response (GO:0001662)2.60047842
198behavioral defense response (GO:0002209)2.60047842
199synaptic transmission (GO:0007268)2.59153465
200positive regulation of dendritic spine development (GO:0060999)2.57569062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.93508897
2EZH2_22144423_ChIP-Seq_EOC_Human5.84494473
3FOXM1_23109430_ChIP-Seq_U2OS_Human5.35351149
4E2F4_17652178_ChIP-ChIP_JURKAT_Human4.33067349
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63980978
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35174152
7GBX2_23144817_ChIP-Seq_PC3_Human3.23522774
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.18622522
9AR_21909140_ChIP-Seq_LNCAP_Human3.10204835
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.74922057
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74545882
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73071125
13E2F1_21310950_ChIP-Seq_MCF-7_Human2.67178689
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66406056
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.65247226
16RARB_27405468_Chip-Seq_BRAIN_Mouse2.63345700
17REST_21632747_ChIP-Seq_MESCs_Mouse2.57278828
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42974231
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.38785718
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37702976
21RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37702976
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35852742
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33886813
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.27331756
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.26638752
26EZH2_27304074_Chip-Seq_ESCs_Mouse2.24511077
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24169393
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23492296
29ELK1_19687146_ChIP-ChIP_HELA_Human2.14655093
30TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.13215102
31MYC_19030024_ChIP-ChIP_MESCs_Mouse2.12110317
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12096342
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.03978147
34REST_18959480_ChIP-ChIP_MESCs_Mouse2.03378733
35SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03139935
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02524656
37JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02395545
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99277548
39* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.98885154
40PADI4_21655091_ChIP-ChIP_MCF-7_Human1.98547524
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98119159
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.88410811
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.87303423
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84496534
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84125175
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.83061760
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.82980517
48NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81936462
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.81927211
50ZNF274_21170338_ChIP-Seq_K562_Hela1.81563591
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81234777
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.80851228
53AR_21572438_ChIP-Seq_LNCaP_Human1.77340618
54CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76288027
55CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.75675614
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.75349878
57DCP1A_22483619_ChIP-Seq_HELA_Human1.75244942
58DROSHA_22980978_ChIP-Seq_HELA_Human1.72956460
59TAF15_26573619_Chip-Seq_HEK293_Human1.72649386
60POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.66718358
61SMAD4_21799915_ChIP-Seq_A2780_Human1.66567631
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.64361827
63TTF2_22483619_ChIP-Seq_HELA_Human1.63365918
64IGF1R_20145208_ChIP-Seq_DFB_Human1.62616239
65EED_16625203_ChIP-ChIP_MESCs_Mouse1.62326678
66SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61109549
67* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60748343
68FUS_26573619_Chip-Seq_HEK293_Human1.60287376
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59953740
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58628403
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57630672
72FOXP3_21729870_ChIP-Seq_TREG_Human1.57425968
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56765723
74* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55449768
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55144080
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.53813042
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.51816861
78P300_19829295_ChIP-Seq_ESCs_Human1.49553799
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49551759
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49377979
81CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48817825
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47813563
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.47488178
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47398111
85HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46046594
86KDM5A_27292631_Chip-Seq_BREAST_Human1.45766509
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.44791656
88* VDR_23849224_ChIP-Seq_CD4+_Human1.44390381
89SOX2_21211035_ChIP-Seq_LN229_Gbm1.44245247
90MYC_18940864_ChIP-ChIP_HL60_Human1.43829723
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.43301579
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.42648801
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40170921
94XRN2_22483619_ChIP-Seq_HELA_Human1.39907522
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39082579
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.35424218
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34728719
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34164445
99VDR_22108803_ChIP-Seq_LS180_Human1.34005576
100RING1B_27294783_Chip-Seq_NPCs_Mouse1.31744235
101GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30358323
102AR_19668381_ChIP-Seq_PC3_Human1.29294679
103* STAT3_23295773_ChIP-Seq_U87_Human1.27959504
104CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27630258
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25804800
106* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24240104
107KDM2B_26808549_Chip-Seq_K562_Human1.22995571
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21578411
109AR_25329375_ChIP-Seq_VCAP_Human1.21563213
110ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20919476
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20620084
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20595033
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20164261
114GABP_19822575_ChIP-Seq_HepG2_Human1.20005626
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18864692
116ERG_21242973_ChIP-ChIP_JURKAT_Human1.18757459
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.18305087
118TCF4_23295773_ChIP-Seq_U87_Human1.17994107
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.17044518
120P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16567576
121CBX2_27304074_Chip-Seq_ESCs_Mouse1.15593318
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15569936
123DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14979546
124E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14397970
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12026972
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10959856
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.09449199
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09202886
129EWS_26573619_Chip-Seq_HEK293_Human1.09079541
130WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08594933
131AHR_22903824_ChIP-Seq_MCF-7_Human1.08023909
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07806077
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07806077
134SOX9_26525672_Chip-Seq_HEART_Mouse1.06951165
135NR3C1_21868756_ChIP-Seq_MCF10A_Human1.06905957
136ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06566879
137RNF2_27304074_Chip-Seq_NSC_Mouse1.06196239
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04701559
139ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03924051
140SMAD3_21741376_ChIP-Seq_ESCs_Human1.02919630
141RXR_22108803_ChIP-Seq_LS180_Human1.02570229
142TP53_16413492_ChIP-PET_HCT116_Human1.02247926
143* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02212427
144* PRDM14_20953172_ChIP-Seq_ESCs_Human1.00955226
145KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00214747
146* ER_23166858_ChIP-Seq_MCF-7_Human0.99978374
147JUN_21703547_ChIP-Seq_K562_Human0.99715337
148TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99147686
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.98130683
150SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97314448
151TCF4_18268006_ChIP-ChIP_LS174T_Human0.97310996
152ZNF263_19887448_ChIP-Seq_K562_Human0.94527566
153CHD1_26751641_Chip-Seq_LNCaP_Human0.93947819
154RUNX2_22187159_ChIP-Seq_PCA_Human0.93318427
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92845765
156NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.92428720
157PKCTHETA_26484144_Chip-Seq_BREAST_Human0.92048206
158ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92016001
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91319125
160IRF1_19129219_ChIP-ChIP_H3396_Human0.90796642
161FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89442139
162ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88927295
163TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.87651181
164SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.86853335
165* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.83878586
166ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.83799304
167EGR1_19374776_ChIP-ChIP_THP-1_Human0.82955449
168CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.81648473
169SOX17_20123909_ChIP-Seq_XEN_Mouse0.81531054
170REST_19997604_ChIP-ChIP_NEURONS_Mouse0.81236722
171KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.78410892
172KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.78410892
173KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.78410892
174SOX2_16153702_ChIP-ChIP_HESCs_Human0.76738852
175FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.75232936
176RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74648041
177NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74438180
178CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.74324474
179NANOG_16153702_ChIP-ChIP_HESCs_Human0.73761204

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86009444
2MP0003880_abnormal_central_pattern4.50892470
3MP0008057_abnormal_DNA_replication4.10046471
4MP0003635_abnormal_synaptic_transmissio3.72288834
5MP0010094_abnormal_chromosome_stability3.69150763
6MP0003693_abnormal_embryo_hatching3.66055599
7MP0004270_analgesia3.61619002
8MP0004957_abnormal_blastocyst_morpholog3.08580238
9MP0002063_abnormal_learning/memory/cond3.04499402
10MP0003111_abnormal_nucleus_morphology2.96979543
11MP0009745_abnormal_behavioral_response2.81262350
12MP0003787_abnormal_imprinting2.75716432
13MP0008058_abnormal_DNA_repair2.72973787
14MP0003077_abnormal_cell_cycle2.69451626
15MP0009046_muscle_twitch2.64109908
16MP0001968_abnormal_touch/_nociception2.63944506
17MP0002796_impaired_skin_barrier2.62443126
18MP0002064_seizures2.60115862
19MP0002734_abnormal_mechanical_nocicepti2.35493969
20MP0002572_abnormal_emotion/affect_behav2.34843258
21* MP0000778_abnormal_nervous_system2.23435664
22MP0005423_abnormal_somatic_nervous2.23272140
23MP0002272_abnormal_nervous_system2.19080490
24MP0001486_abnormal_startle_reflex2.18839680
25* MP0002184_abnormal_innervation2.15924844
26MP0003718_maternal_effect2.04403459
27MP0010678_abnormal_skin_adnexa1.98320110
28MP0001501_abnormal_sleep_pattern1.94949060
29MP0002735_abnormal_chemical_nociception1.93557317
30MP0008932_abnormal_embryonic_tissue1.91324943
31MP0002736_abnormal_nociception_after1.87462586
32MP0002733_abnormal_thermal_nociception1.84600896
33* MP0004811_abnormal_neuron_physiology1.83416645
34MP0002067_abnormal_sensory_capabilities1.82638736
35MP0001440_abnormal_grooming_behavior1.77017948
36MP0008007_abnormal_cellular_replicative1.75145005
37MP0005501_abnormal_skin_physiology1.73088664
38MP0010352_gastrointestinal_tract_polyps1.71041813
39MP0000579_abnormal_nail_morphology1.69041487
40MP0004924_abnormal_behavior1.64493052
41MP0005386_behavior/neurological_phenoty1.64493052
42MP0001730_embryonic_growth_arrest1.62618534
43MP0001970_abnormal_pain_threshold1.61064872
44MP0009780_abnormal_chondrocyte_physiolo1.60970446
45MP0003123_paternal_imprinting1.60191670
46MP0003941_abnormal_skin_development1.60159426
47MP0000427_abnormal_hair_cycle1.59777609
48MP0006276_abnormal_autonomic_nervous1.58067056
49MP0000569_abnormal_digit_pigmentation1.55282128
50MP0000350_abnormal_cell_proliferation1.54767601
51MP0002210_abnormal_sex_determination1.52498657
52MP0000013_abnormal_adipose_tissue1.52326443
53* MP0000955_abnormal_spinal_cord1.52028397
54MP0003122_maternal_imprinting1.51766997
55MP0008569_lethality_at_weaning1.51235462
56MP0003121_genomic_imprinting1.50463517
57MP0000383_abnormal_hair_follicle1.48357734
58MP0005380_embryogenesis_phenotype1.47811649
59MP0001672_abnormal_embryogenesis/_devel1.47811649
60MP0002557_abnormal_social/conspecific_i1.46288682
61* MP0002882_abnormal_neuron_morphology1.45465730
62MP0001697_abnormal_embryo_size1.44967610
63MP0002822_catalepsy1.40811633
64MP0002909_abnormal_adrenal_gland1.39970335
65MP0004858_abnormal_nervous_system1.38200483
66MP0001984_abnormal_olfaction1.38119894
67MP0003329_amyloid_beta_deposits1.37908850
68MP0010307_abnormal_tumor_latency1.37779946
69MP0006292_abnormal_olfactory_placode1.36148681
70MP0002877_abnormal_melanocyte_morpholog1.35582405
71* MP0002152_abnormal_brain_morphology1.35243136
72MP0009697_abnormal_copulation1.34148153
73MP0000647_abnormal_sebaceous_gland1.33362709
74* MP0002066_abnormal_motor_capabilities/c1.32297224
75MP0004185_abnormal_adipocyte_glucose1.31256610
76MP0001929_abnormal_gametogenesis1.29739905
77MP0004145_abnormal_muscle_electrophysio1.29405682
78MP0003879_abnormal_hair_cell1.28442533
79MP0002084_abnormal_developmental_patter1.26411312
80MP0003984_embryonic_growth_retardation1.23866353
81MP0004197_abnormal_fetal_growth/weight/1.22152410
82MP0002160_abnormal_reproductive_system1.21758453
83MP0002088_abnormal_embryonic_growth/wei1.21711374
84MP0002085_abnormal_embryonic_tissue1.21452683
85MP0008877_abnormal_DNA_methylation1.21143874
86MP0004885_abnormal_endolymph1.20862779
87MP0009672_abnormal_birth_weight1.20666248
88MP0005187_abnormal_penis_morphology1.18340806
89MP0000751_myopathy1.15895506
90MP0003937_abnormal_limbs/digits/tail_de1.15232713
91MP0002837_dystrophic_cardiac_calcinosis1.13571317
92MP0001188_hyperpigmentation1.12578605
93MP0010234_abnormal_vibrissa_follicle1.12489200
94MP0001145_abnormal_male_reproductive1.11392815
95MP0002080_prenatal_lethality1.09905546
96* MP0003861_abnormal_nervous_system1.09306151
97MP0005645_abnormal_hypothalamus_physiol1.08719109
98MP0000377_abnormal_hair_follicle1.08198710
99MP0000653_abnormal_sex_gland1.05130820
100MP0003633_abnormal_nervous_system0.99948251
101MP0002009_preneoplasia0.98681365
102MP0003786_premature_aging0.98514608
103MP0004147_increased_porphyrin_level0.96509945
104MP0003631_nervous_system_phenotype0.95791109
105MP0004130_abnormal_muscle_cell0.95548154
106MP0000003_abnormal_adipose_tissue0.94249376
107MP0001299_abnormal_eye_distance/0.94138530
108MP0000762_abnormal_tongue_morphology0.93834495
109MP0002086_abnormal_extraembryonic_tissu0.93490137
110MP0001293_anophthalmia0.93073756
111MP0002098_abnormal_vibrissa_morphology0.91846685
112MP0005076_abnormal_cell_differentiation0.90314507
113MP0003943_abnormal_hepatobiliary_system0.88937268
114MP0005394_taste/olfaction_phenotype0.88897286
115MP0005499_abnormal_olfactory_system0.88897286
116MP0000631_abnormal_neuroendocrine_gland0.88422320
117MP0006035_abnormal_mitochondrial_morpho0.87923795
118MP0001529_abnormal_vocalization0.87813967
119MP0004233_abnormal_muscle_weight0.87513501
120MP0003698_abnormal_male_reproductive0.87054134
121MP0003890_abnormal_embryonic-extraembry0.86493565
122MP0010771_integument_phenotype0.85935737
123MP0009703_decreased_birth_body0.85461651
124MP0001919_abnormal_reproductive_system0.84702928
125MP0001177_atelectasis0.84293177
126MP0005623_abnormal_meninges_morphology0.84249203
127MP0004215_abnormal_myocardial_fiber0.84136806
128MP0003699_abnormal_female_reproductive0.82670061
129MP0000313_abnormal_cell_death0.82616717
130MP0001485_abnormal_pinna_reflex0.82446397
131MP0001216_abnormal_epidermal_layer0.82272060
132MP0003632_abnormal_nervous_system0.80043547
133* MP0002752_abnormal_somatic_nervous0.79196659
134MP0000566_synostosis0.79142310
135MP0005389_reproductive_system_phenotype0.79081747
136MP0001286_abnormal_eye_development0.78943385
137MP0008789_abnormal_olfactory_epithelium0.78637609
138MP0004264_abnormal_extraembryonic_tissu0.78506426
139MP0000358_abnormal_cell_content/0.77588338
140MP0001502_abnormal_circadian_rhythm0.77002792
141MP0003119_abnormal_digestive_system0.76868881
142MP0003935_abnormal_craniofacial_develop0.76558310
143MP0003567_abnormal_fetal_cardiomyocyte0.76534556
144MP0004742_abnormal_vestibular_system0.75491664
145MP0001905_abnormal_dopamine_level0.75053711
146MP0003755_abnormal_palate_morphology0.74683441
147MP0002161_abnormal_fertility/fecundity0.74155109
148MP0002234_abnormal_pharynx_morphology0.73361527
149MP0005379_endocrine/exocrine_gland_phen0.72916743
150MP0000537_abnormal_urethra_morphology0.72151077
151MP0002177_abnormal_outer_ear0.72040869
152MP0000428_abnormal_craniofacial_morphol0.71488361
153MP0002069_abnormal_eating/drinking_beha0.70928055
154MP0001963_abnormal_hearing_physiology0.70612705
155MP0003936_abnormal_reproductive_system0.69671427
156MP0003634_abnormal_glial_cell0.69560515
157MP0001346_abnormal_lacrimal_gland0.68883490
158MP0010030_abnormal_orbit_morphology0.68508933
159MP0004085_abnormal_heartbeat0.68279997
160* MP0002081_perinatal_lethality0.66936683
161MP0002095_abnormal_skin_pigmentation0.66711326
162MP0002229_neurodegeneration0.66478366
163MP0000627_abnormal_mammary_gland0.66458890
164MP0003221_abnormal_cardiomyocyte_apopto0.63239632
165MP0010769_abnormal_survival0.62221055
166MP0002082_postnatal_lethality0.61859099
167MP0010770_preweaning_lethality0.61859099
168MP0000747_muscle_weakness0.61712141
169MP0004484_altered_response_of0.60720561
170MP0005535_abnormal_body_temperature0.60663923
171MP0006072_abnormal_retinal_apoptosis0.60141646
172MP0010768_mortality/aging0.58776304
173MP0005551_abnormal_eye_electrophysiolog0.58297088
174MP0005375_adipose_tissue_phenotype0.57026526
175* MP0001943_abnormal_respiration0.55609293
176MP0008874_decreased_physiological_sensi0.55462913

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.76806043
2Myokymia (HP:0002411)4.57012985
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.39273323
4Chromsome breakage (HP:0040012)4.25455679
5Focal seizures (HP:0007359)4.14956102
6Visual hallucinations (HP:0002367)4.01696826
7Atonic seizures (HP:0010819)3.65290911
8Febrile seizures (HP:0002373)3.62869183
9Progressive cerebellar ataxia (HP:0002073)3.57864641
10Epileptic encephalopathy (HP:0200134)3.48121583
11Abnormality of nail color (HP:0100643)3.41944450
12Increased nuchal translucency (HP:0010880)3.29467417
13Shoulder girdle muscle weakness (HP:0003547)3.23705377
14Absence seizures (HP:0002121)3.22122521
15Insidious onset (HP:0003587)3.18611235
16Termporal pattern (HP:0011008)3.18611235
17Broad-based gait (HP:0002136)3.17307182
18Action tremor (HP:0002345)3.12284231
19Poor eye contact (HP:0000817)3.09033242
20Pelvic girdle muscle weakness (HP:0003749)2.92460164
21Amblyopia (HP:0000646)2.91151075
22Abnormality of chromosome stability (HP:0003220)2.90341696
23Hyperventilation (HP:0002883)2.89154511
24Generalized tonic-clonic seizures (HP:0002069)2.85214603
25Abnormality of the musculature of the pelvis (HP:0001469)2.82716957
26Abnormality of the hip-girdle musculature (HP:0001445)2.82716957
27Abnormality of the preputium (HP:0100587)2.81549925
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.76086139
29Abnormal social behavior (HP:0012433)2.73920662
30Impaired social interactions (HP:0000735)2.73920662
31Excessive salivation (HP:0003781)2.73645159
32Drooling (HP:0002307)2.73645159
33Genetic anticipation (HP:0003743)2.73626113
34Abnormality of the lower motor neuron (HP:0002366)2.72133411
35Dialeptic seizures (HP:0011146)2.71803097
36Impaired vibration sensation in the lower limbs (HP:0002166)2.70858590
37Urinary urgency (HP:0000012)2.66553078
38Neoplasm of the adrenal cortex (HP:0100641)2.64200044
39Gaze-evoked nystagmus (HP:0000640)2.62929805
40Nephroblastoma (Wilms tumor) (HP:0002667)2.59347640
41Birth length less than 3rd percentile (HP:0003561)2.58855563
42Urinary bladder sphincter dysfunction (HP:0002839)2.57045617
43Truncal ataxia (HP:0002078)2.53230951
44Progressive inability to walk (HP:0002505)2.53049147
45Meckel diverticulum (HP:0002245)2.51878950
46Papilledema (HP:0001085)2.49631119
47Depression (HP:0000716)2.48472359
48Abnormality of the corticospinal tract (HP:0002492)2.48403817
49Impaired smooth pursuit (HP:0007772)2.47339399
50Embryonal renal neoplasm (HP:0011794)2.43151498
51Supranuclear gaze palsy (HP:0000605)2.41514762
52Dysmetric saccades (HP:0000641)2.37411500
53Inappropriate behavior (HP:0000719)2.34880163
54Curly hair (HP:0002212)2.34270685
55Dysdiadochokinesis (HP:0002075)2.33095206
56Stereotypic behavior (HP:0000733)2.31734446
57Abnormality of the ileum (HP:0001549)2.31547258
58Septate vagina (HP:0001153)2.29725938
59Abnormality of the labia minora (HP:0012880)2.28369558
60Absent speech (HP:0001344)2.27742487
61Hyperthyroidism (HP:0000836)2.25599918
62Small intestinal stenosis (HP:0012848)2.23893838
63Duodenal stenosis (HP:0100867)2.23893838
64Rhabdomyosarcoma (HP:0002859)2.21839911
65Abnormal lung lobation (HP:0002101)2.21398851
66Abnormality of the carotid arteries (HP:0005344)2.20427075
67Mutism (HP:0002300)2.19385105
68Colon cancer (HP:0003003)2.18245826
69Dysmetria (HP:0001310)2.17558908
70Myelodysplasia (HP:0002863)2.13630775
71Cortical dysplasia (HP:0002539)2.12938288
72Abnormality of ocular smooth pursuit (HP:0000617)2.11572486
73Medulloblastoma (HP:0002885)2.11569904
74Cafe-au-lait spot (HP:0000957)2.11477968
75Oligodactyly (hands) (HP:0001180)2.11023766
76Microglossia (HP:0000171)2.10687255
77Epileptiform EEG discharges (HP:0011182)2.10327781
78Blepharitis (HP:0000498)2.10154835
79Progressive external ophthalmoplegia (HP:0000590)2.10091201
80Anxiety (HP:0000739)2.10053171
81Amyotrophic lateral sclerosis (HP:0007354)2.09927145
82Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09505185
83Hypoplasia of the brainstem (HP:0002365)2.09505185
84Proximal placement of thumb (HP:0009623)2.08029556
85Ankyloglossia (HP:0010296)2.04873737
86Lower limb asymmetry (HP:0100559)2.04611064
87Postural instability (HP:0002172)2.04038079
88Papillary thyroid carcinoma (HP:0002895)2.03105619
89EEG with generalized epileptiform discharges (HP:0011198)2.02651605
90Cystic hygroma (HP:0000476)2.02160803
91Pointed chin (HP:0000307)2.01847406
92Protruding tongue (HP:0010808)2.01289356
93Neoplasm of the peripheral nervous system (HP:0100007)2.01209467
94Abnormality of chromosome segregation (HP:0002916)2.00822945
95Deep palmar crease (HP:0006191)2.00526393
96Megalencephaly (HP:0001355)2.00280251
97Inability to walk (HP:0002540)1.99200948
98Pheochromocytoma (HP:0002666)1.98104797
99Glioma (HP:0009733)1.98100788
100Ectopic kidney (HP:0000086)1.97789384
101Retinal dysplasia (HP:0007973)1.96006203
102Exotropia (HP:0000577)1.95992805
103Sensory axonal neuropathy (HP:0003390)1.94668534
104Overlapping toe (HP:0001845)1.94307139
105Deviation of the thumb (HP:0009603)1.93910326
106Hypsarrhythmia (HP:0002521)1.93821755
107Increased hepatocellular lipid droplets (HP:0006565)1.92829514
108Volvulus (HP:0002580)1.92088520
109Abnormality of the duodenum (HP:0002246)1.91770995
110Insomnia (HP:0100785)1.89837723
111Failure to thrive in infancy (HP:0001531)1.89443256
112Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.88981147
113Abnormality of alanine metabolism (HP:0010916)1.88981147
114Hyperalaninemia (HP:0003348)1.88981147
115Intellectual disability, profound (HP:0002187)1.88824430
116Spastic gait (HP:0002064)1.88551133
117Sloping forehead (HP:0000340)1.88150981
118Clubbing of toes (HP:0100760)1.88141308
119Resting tremor (HP:0002322)1.87181122
120Facial hemangioma (HP:0000329)1.85066707
121Aqueductal stenosis (HP:0002410)1.83846087
122Multiple enchondromatosis (HP:0005701)1.83756120
123Oral leukoplakia (HP:0002745)1.83601473
124Patellar aplasia (HP:0006443)1.82332149
125Choanal atresia (HP:0000453)1.79448949
126Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.79129659
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.79129659
128Annular pancreas (HP:0001734)1.79072216
129Breast carcinoma (HP:0003002)1.78727550
130Cerebral inclusion bodies (HP:0100314)1.78715340
131Ependymoma (HP:0002888)1.76768986
132Neuroendocrine neoplasm (HP:0100634)1.76666726
133Abnormality of methionine metabolism (HP:0010901)1.76101067
134Gastroesophageal reflux (HP:0002020)1.75277175
135Abnormality of salivation (HP:0100755)1.75139028
136Oligodactyly (HP:0012165)1.74443469
137Astrocytoma (HP:0009592)1.73722156
138Abnormality of the astrocytes (HP:0100707)1.73722156
139Abnormal eating behavior (HP:0100738)1.73135805
140Asymmetry of the thorax (HP:0001555)1.73024297
141Sporadic (HP:0003745)1.72342059
142Obstructive sleep apnea (HP:0002870)1.72303681
143Intention tremor (HP:0002080)1.72001297
144Macroorchidism (HP:0000053)1.71943992
145Incomplete penetrance (HP:0003829)1.71097406
146Ankle clonus (HP:0011448)1.70860702
147Hypoplastic labia majora (HP:0000059)1.70785850
148Diplopia (HP:0000651)1.70408482
149Abnormality of binocular vision (HP:0011514)1.70408482
150Congenital ichthyosiform erythroderma (HP:0007431)1.68879721
151Bradykinesia (HP:0002067)1.68732019
152Aplasia/Hypoplasia of the patella (HP:0006498)1.66693592
153Thyroid carcinoma (HP:0002890)1.66142489
154Gonadotropin excess (HP:0000837)1.65901041
155Type II lissencephaly (HP:0007260)1.65429993
156Oligomenorrhea (HP:0000876)1.65374984
157Embryonal neoplasm (HP:0002898)1.64622438
158Heterotopia (HP:0002282)1.64541496
159Fetal akinesia sequence (HP:0001989)1.64083475
160Hypoventilation (HP:0002791)1.63771361
161Low posterior hairline (HP:0002162)1.63567152
162Gait ataxia (HP:0002066)1.63522637
163Hemiparesis (HP:0001269)1.63099028
164Acute myeloid leukemia (HP:0004808)1.62697485
165Truncal obesity (HP:0001956)1.62668879
166Progressive muscle weakness (HP:0003323)1.61982280
167Obsessive-compulsive behavior (HP:0000722)1.61383032
168Fair hair (HP:0002286)1.61326356
169Deep philtrum (HP:0002002)1.60668908
170Duplicated collecting system (HP:0000081)1.59368128
171Uterine leiomyosarcoma (HP:0002891)1.59240597
172Leiomyosarcoma (HP:0100243)1.59240597
173Biliary tract neoplasm (HP:0100574)1.57988287
174Horseshoe kidney (HP:0000085)1.57813862
175Lipid accumulation in hepatocytes (HP:0006561)1.57779112
176Absent thumb (HP:0009777)1.57163297
177Sparse scalp hair (HP:0002209)1.56987867
178Atresia of the external auditory canal (HP:0000413)1.55951731
179Radioulnar synostosis (HP:0002974)1.55617951
180Aplasia/Hypoplasia of the sternum (HP:0006714)1.55257836
181Cerebellar dysplasia (HP:0007033)1.55152487
182Neoplasm of the thyroid gland (HP:0100031)1.54910165
183Absent radius (HP:0003974)1.53431054
184Capillary hemangiomas (HP:0005306)1.53355839
185Sandal gap (HP:0001852)1.52753869
186Horizontal nystagmus (HP:0000666)1.52400494
187Onycholysis (HP:0001806)1.52392230
188Arteriovenous malformation (HP:0100026)1.51622894
189Palmar hyperkeratosis (HP:0010765)1.51537407
190Abnormality of hair growth rate (HP:0011363)1.51482677
191Slow-growing hair (HP:0002217)1.51482677

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.85964162
2MAP3K93.60869922
3EPHA43.55292612
4TSSK63.39483541
5MARK13.31816079
6EIF2AK33.26822435
7MAP3K43.14223353
8MINK12.83124637
9TAF12.76275728
10TTK2.74305352
11KSR12.71837437
12WEE12.62309629
13PBK2.47568149
14SRPK12.43741160
15BUB12.23047757
16MAP2K72.17255981
17MAP2K42.12692849
18KSR22.09660261
19PAK62.03395696
20EIF2AK12.00317237
21STK31.87630217
22PLK21.84376628
23CDK191.82762111
24DAPK21.72346616
25PNCK1.71307216
26SIK21.69838315
27LATS21.67468247
28RIPK41.63967439
29STK241.60683545
30PLK11.58745321
31MKNK21.58310037
32PLK41.55310260
33CAMKK11.47835046
34MAP3K121.44179500
35NTRK21.42556821
36CHEK21.39875162
37SMG11.39185326
38BRSK21.37577455
39TRIM281.34040192
40EIF2AK21.32962677
41CDK51.32741380
42CASK1.31419160
43MST41.28748646
44VRK21.28406931
45ATR1.27442948
46STK111.26257893
47NTRK11.25577737
48ZAK1.25506634
49MKNK11.24782567
50RET1.23826581
51NUAK11.20001035
52CDK121.19827486
53TYRO31.17568198
54MAPK131.17385465
55RPS6KB21.16781714
56STK38L1.16600296
57DAPK11.16537678
58ALK1.15558588
59PRKD31.15000056
60LATS11.14070851
61MAP3K61.11103519
62CDC71.11016039
63PRPF4B1.10353681
64MAP3K21.09070092
65UHMK11.07980641
66FGFR21.07039109
67PRKCG1.06749858
68BRAF1.06463746
69CAMKK21.05475937
70CDK71.04920158
71PHKG21.03194963
72PHKG11.03194963
73TNIK1.02811894
74CHEK11.02094213
75CSNK1G20.98800076
76CDK140.97999106
77ATM0.97969277
78AURKB0.97548258
79STK390.95924966
80ERBB30.94772074
81ARAF0.91604296
82PLK30.90627136
83GRK50.88896556
84DYRK1A0.88036126
85MET0.87896093
86SGK4940.87212077
87SGK2230.87212077
88CDK180.86536614
89EEF2K0.86313520
90CDK150.84889937
91SGK30.83526430
92NEK60.82978300
93SGK20.79973474
94STK380.78906734
95CCNB10.78821033
96AURKA0.78676116
97RPS6KA40.77769976
98CAMK1G0.77360908
99VRK10.77070364
100BRSK10.75331224
101SCYL20.74893221
102CDK11A0.72305923
103SGK10.72089389
104FRK0.71446656
105CDK10.70483274
106MAP3K130.68343177
107TRIB30.67766522
108PAK30.66802912
109PRKCI0.65694217
110TAOK10.65286494
111MAP3K80.64611020
112NEK10.64351286
113BRD40.63545382
114CDK20.63290470
115CAMK2A0.62787364
116WNK40.61815727
117RAF10.60858380
118DYRK20.59313011
119BMPR20.58837226
120PDK10.58329038
121MAPK100.58233909
122LMTK20.55390070
123YES10.53579480
124ACVR1B0.52942351
125MAPKAPK50.52530124
126PRKCH0.51646164
127ERBB40.51036903
128STK160.50048371
129BCR0.49095649
130ICK0.48000763
131RPS6KA30.46975224
132CAMK2B0.45965768
133EPHA20.45784833
134PDPK10.44482602
135CSNK1E0.43936731
136PRKCZ0.42716699
137MAP3K50.42544817
138WNK10.41918650
139PDGFRB0.41639039
140CDK30.41517305
141PASK0.41362756
142DYRK30.41284929
143CSNK2A20.39222031
144PKN20.38838108
145CAMK10.37986208
146CSNK1G30.37394696
147NME10.37386267
148CAMK1D0.36756352
149PRKCE0.36600125
150CDK80.36512108
151MAP3K100.36363749
152PDK30.34841094
153PDK40.34841094
154FGFR30.34782619
155NEK90.34560771
156PTK2B0.34078061
157MAPK80.33706074
158PRKCB0.33697369
159CSNK1D0.33248070
160NEK20.33238668
161CDK90.32934039
162RPS6KB10.32903980
163AKT20.32775092
164PRKDC0.32753989

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.67697073
2Cell cycle_Homo sapiens_hsa041103.32295986
3Mismatch repair_Homo sapiens_hsa034303.30635690
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24093270
5RNA transport_Homo sapiens_hsa030133.09490968
6Nicotine addiction_Homo sapiens_hsa050333.01684365
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.83449096
8Non-homologous end-joining_Homo sapiens_hsa034502.72862677
9Basal transcription factors_Homo sapiens_hsa030222.69763689
10Long-term potentiation_Homo sapiens_hsa047202.67905178
11Homologous recombination_Homo sapiens_hsa034402.62563460
12Synaptic vesicle cycle_Homo sapiens_hsa047212.62243371
13Fanconi anemia pathway_Homo sapiens_hsa034602.52821549
14Olfactory transduction_Homo sapiens_hsa047402.47605483
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.35357900
16Nucleotide excision repair_Homo sapiens_hsa034202.33273505
17Circadian entrainment_Homo sapiens_hsa047132.31882815
18Spliceosome_Homo sapiens_hsa030402.26373019
19Glutamatergic synapse_Homo sapiens_hsa047242.23647197
20Amphetamine addiction_Homo sapiens_hsa050312.22498378
21Dopaminergic synapse_Homo sapiens_hsa047282.21662792
22GABAergic synapse_Homo sapiens_hsa047272.13112337
23Base excision repair_Homo sapiens_hsa034102.09091401
24Morphine addiction_Homo sapiens_hsa050322.08793605
25Protein export_Homo sapiens_hsa030602.04796600
26One carbon pool by folate_Homo sapiens_hsa006702.04592867
27RNA degradation_Homo sapiens_hsa030182.01210017
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.78500765
29RNA polymerase_Homo sapiens_hsa030201.76120937
30Cholinergic synapse_Homo sapiens_hsa047251.75575824
31Long-term depression_Homo sapiens_hsa047301.74153149
32Salivary secretion_Homo sapiens_hsa049701.68977717
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.66525384
34Taste transduction_Homo sapiens_hsa047421.65006421
35Oocyte meiosis_Homo sapiens_hsa041141.64573787
36Oxytocin signaling pathway_Homo sapiens_hsa049211.64265986
37Renin secretion_Homo sapiens_hsa049241.62638429
38Proteasome_Homo sapiens_hsa030501.57629532
39Gastric acid secretion_Homo sapiens_hsa049711.56096876
40GnRH signaling pathway_Homo sapiens_hsa049121.53627659
41Serotonergic synapse_Homo sapiens_hsa047261.51820791
42p53 signaling pathway_Homo sapiens_hsa041151.50592875
43Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46501160
44Glioma_Homo sapiens_hsa052141.45948609
45Insulin secretion_Homo sapiens_hsa049111.42614255
46Cocaine addiction_Homo sapiens_hsa050301.36428426
47Selenocompound metabolism_Homo sapiens_hsa004501.35530306
48Gap junction_Homo sapiens_hsa045401.35140062
49Estrogen signaling pathway_Homo sapiens_hsa049151.33370458
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.33261098
51Type II diabetes mellitus_Homo sapiens_hsa049301.31481114
52Dorso-ventral axis formation_Homo sapiens_hsa043201.30331628
53Axon guidance_Homo sapiens_hsa043601.28877597
54ErbB signaling pathway_Homo sapiens_hsa040121.27956394
55Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.25750914
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25671783
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23907761
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23711414
59Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21878055
60Ribosome_Homo sapiens_hsa030101.21077525
61Pyrimidine metabolism_Homo sapiens_hsa002401.20124776
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.19237629
63Calcium signaling pathway_Homo sapiens_hsa040201.18037028
64cAMP signaling pathway_Homo sapiens_hsa040241.15719588
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15601194
66mTOR signaling pathway_Homo sapiens_hsa041501.09341424
67Melanogenesis_Homo sapiens_hsa049161.08257382
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07668535
69cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07153823
70Endometrial cancer_Homo sapiens_hsa052131.04701892
71VEGF signaling pathway_Homo sapiens_hsa043701.01590405
72Neurotrophin signaling pathway_Homo sapiens_hsa047221.00737900
73Renal cell carcinoma_Homo sapiens_hsa052110.97626877
74MicroRNAs in cancer_Homo sapiens_hsa052060.93376433
75Non-small cell lung cancer_Homo sapiens_hsa052230.91652567
76Purine metabolism_Homo sapiens_hsa002300.91054990
77Colorectal cancer_Homo sapiens_hsa052100.90849882
78MAPK signaling pathway_Homo sapiens_hsa040100.89524739
79Phototransduction_Homo sapiens_hsa047440.86020482
80Choline metabolism in cancer_Homo sapiens_hsa052310.84524190
81Collecting duct acid secretion_Homo sapiens_hsa049660.83842290
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82615426
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81268365
84Alcoholism_Homo sapiens_hsa050340.80303198
85Folate biosynthesis_Homo sapiens_hsa007900.79568061
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78029522
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.77670276
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.76545889
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.76163494
90Glucagon signaling pathway_Homo sapiens_hsa049220.75990814
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75029351
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.73673287
93Insulin signaling pathway_Homo sapiens_hsa049100.73277194
94Steroid biosynthesis_Homo sapiens_hsa001000.71855956
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70805038
96Inositol phosphate metabolism_Homo sapiens_hsa005620.69899053
97Rap1 signaling pathway_Homo sapiens_hsa040150.69249827
98Cardiac muscle contraction_Homo sapiens_hsa042600.69247032
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68383340
100Dilated cardiomyopathy_Homo sapiens_hsa054140.66382524
101Ras signaling pathway_Homo sapiens_hsa040140.65066843
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64907284
103Nitrogen metabolism_Homo sapiens_hsa009100.61777219
104Wnt signaling pathway_Homo sapiens_hsa043100.61429151
105Propanoate metabolism_Homo sapiens_hsa006400.59205085
106Thyroid hormone synthesis_Homo sapiens_hsa049180.58853342
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58373539
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.58313246
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57506204
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57338518
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56433357
112AMPK signaling pathway_Homo sapiens_hsa041520.56252205
113Vitamin B6 metabolism_Homo sapiens_hsa007500.55779183
114FoxO signaling pathway_Homo sapiens_hsa040680.53957453
115Hippo signaling pathway_Homo sapiens_hsa043900.53810276
116Prostate cancer_Homo sapiens_hsa052150.52973022
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52788185
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52617610
119Tight junction_Homo sapiens_hsa045300.52327973
120N-Glycan biosynthesis_Homo sapiens_hsa005100.52256981
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50936064
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50887878
123Endocytosis_Homo sapiens_hsa041440.50821970
124Vibrio cholerae infection_Homo sapiens_hsa051100.50702516
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.50485392
126mRNA surveillance pathway_Homo sapiens_hsa030150.50288528
127Melanoma_Homo sapiens_hsa052180.48467465
128Pancreatic secretion_Homo sapiens_hsa049720.48141923
129Prolactin signaling pathway_Homo sapiens_hsa049170.47730968
130Pyruvate metabolism_Homo sapiens_hsa006200.46001736
131Epstein-Barr virus infection_Homo sapiens_hsa051690.45444581
132Chronic myeloid leukemia_Homo sapiens_hsa052200.45328121
133Bladder cancer_Homo sapiens_hsa052190.44807870
134Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44640712
135TGF-beta signaling pathway_Homo sapiens_hsa043500.43883487
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43220059
137Thyroid cancer_Homo sapiens_hsa052160.42168370
138Circadian rhythm_Homo sapiens_hsa047100.42107055
139Huntingtons disease_Homo sapiens_hsa050160.42069703
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40413801
141Pancreatic cancer_Homo sapiens_hsa052120.40264757
142Lysine degradation_Homo sapiens_hsa003100.40229802
143Viral carcinogenesis_Homo sapiens_hsa052030.40054785
144Hedgehog signaling pathway_Homo sapiens_hsa043400.38532090
145Adherens junction_Homo sapiens_hsa045200.38487513
146Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.38341418
147Platelet activation_Homo sapiens_hsa046110.37635059
148Biosynthesis of amino acids_Homo sapiens_hsa012300.37342298
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29991696
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28788660

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