FBXO48

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.49805929
2behavioral response to nicotine (GO:0035095)5.24921814
3protein localization to kinetochore (GO:0034501)5.23205207
4protein localization to chromosome, centromeric region (GO:0071459)4.78328534
5mitotic chromosome condensation (GO:0007076)4.63105238
6telomere maintenance via semi-conservative replication (GO:0032201)4.62629309
7DNA strand elongation involved in DNA replication (GO:0006271)4.60123806
8sister chromatid segregation (GO:0000819)4.44782210
9mitotic recombination (GO:0006312)4.42592085
10DNA strand elongation (GO:0022616)4.42268684
11L-fucose catabolic process (GO:0042355)4.40452890
12fucose catabolic process (GO:0019317)4.40452890
13L-fucose metabolic process (GO:0042354)4.40452890
14telomere maintenance via recombination (GO:0000722)4.29267110
15mitotic sister chromatid segregation (GO:0000070)4.25893362
16nuclear pore complex assembly (GO:0051292)4.19052849
17indolalkylamine metabolic process (GO:0006586)4.11755631
18tryptophan catabolic process (GO:0006569)4.10562372
19indole-containing compound catabolic process (GO:0042436)4.10562372
20indolalkylamine catabolic process (GO:0046218)4.10562372
21mitotic sister chromatid cohesion (GO:0007064)4.08216501
22DNA replication initiation (GO:0006270)4.05553825
23water-soluble vitamin biosynthetic process (GO:0042364)4.02902584
24kynurenine metabolic process (GO:0070189)3.99389074
25nuclear pore organization (GO:0006999)3.94310749
26regulation of DNA endoreduplication (GO:0032875)3.93351348
27regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.87438359
28mitotic nuclear envelope disassembly (GO:0007077)3.81845977
29nucleotide-excision repair, DNA gap filling (GO:0006297)3.75763158
30kinetochore organization (GO:0051383)3.71442241
31regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.71269630
32response to pheromone (GO:0019236)3.70345166
33DNA replication checkpoint (GO:0000076)3.70215295
34translesion synthesis (GO:0019985)3.70035402
35attachment of spindle microtubules to kinetochore (GO:0008608)3.69858444
36DNA deamination (GO:0045006)3.68043835
37tryptophan metabolic process (GO:0006568)3.66891561
38telomere maintenance via telomere lengthening (GO:0010833)3.63106481
39regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.62581205
40DNA topological change (GO:0006265)3.62480486
41DNA duplex unwinding (GO:0032508)3.59684407
42nuclear envelope disassembly (GO:0051081)3.59138766
43membrane disassembly (GO:0030397)3.59138766
44DNA geometric change (GO:0032392)3.58088983
45folic acid-containing compound biosynthetic process (GO:0009396)3.56018840
46DNA replication-dependent nucleosome assembly (GO:0006335)3.54299117
47DNA replication-dependent nucleosome organization (GO:0034723)3.54299117
48CENP-A containing nucleosome assembly (GO:0034080)3.52786327
49DNA replication-independent nucleosome assembly (GO:0006336)3.43390298
50DNA replication-independent nucleosome organization (GO:0034724)3.43390298
51chromatin remodeling at centromere (GO:0031055)3.42819436
52cellular ketone body metabolic process (GO:0046950)3.41841565
53pore complex assembly (GO:0046931)3.41758339
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.39489985
55meiotic chromosome segregation (GO:0045132)3.38652974
56chromatin assembly or disassembly (GO:0006333)3.37406917
57sulfation (GO:0051923)3.32543938
58positive regulation of gamma-delta T cell activation (GO:0046645)3.30883236
59positive regulation of chromosome segregation (GO:0051984)3.23774299
60protein localization to chromosome (GO:0034502)3.23093791
61indole-containing compound metabolic process (GO:0042430)3.21804387
62dosage compensation (GO:0007549)3.20894197
63antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.15479740
64antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.15479740
65neural tube formation (GO:0001841)3.13629609
66telomere maintenance (GO:0000723)3.13136381
67DNA conformation change (GO:0071103)3.12798955
68detection of light stimulus involved in visual perception (GO:0050908)3.12475245
69detection of light stimulus involved in sensory perception (GO:0050962)3.12475245
70chromosome condensation (GO:0030261)3.12406388
71postreplication repair (GO:0006301)3.11936654
72ketone body metabolic process (GO:1902224)3.10222085
73platelet dense granule organization (GO:0060155)3.10052117
74regulation of histone H3-K9 methylation (GO:0051570)3.09873430
75telomere organization (GO:0032200)3.09837603
76establishment of chromosome localization (GO:0051303)3.09148320
77piRNA metabolic process (GO:0034587)3.09080411
78negative regulation of RNA splicing (GO:0033119)3.08983864
79protein K11-linked deubiquitination (GO:0035871)3.06530026
80replication fork processing (GO:0031297)3.05708721
81regulation of glucokinase activity (GO:0033131)3.04326203
82regulation of hexokinase activity (GO:1903299)3.04326203
83positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.03052253
84positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.03052253
85positive regulation of mitotic sister chromatid separation (GO:1901970)3.03052253
86antigen processing and presentation of endogenous antigen (GO:0019883)3.01690188
87serotonin metabolic process (GO:0042428)3.01611254
88regulation of sister chromatid cohesion (GO:0007063)3.01545843
89mitotic metaphase plate congression (GO:0007080)2.99443161
90negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99097725
91protein polyglutamylation (GO:0018095)2.98479815
92primary amino compound metabolic process (GO:1901160)2.98181153
93chromosome segregation (GO:0007059)2.98034465
94amine catabolic process (GO:0009310)2.97631499
95cellular biogenic amine catabolic process (GO:0042402)2.97631499
96reflex (GO:0060004)2.97396989
97kidney morphogenesis (GO:0060993)2.95895136
98cellular response to ATP (GO:0071318)2.94125670
99negative regulation of telomere maintenance (GO:0032205)2.92269519
100regulation of spindle organization (GO:0090224)2.91233218
101positive regulation of B cell differentiation (GO:0045579)2.90210727
102mRNA stabilization (GO:0048255)2.90156247
103RNA stabilization (GO:0043489)2.90156247
104axoneme assembly (GO:0035082)2.89982232
105mannosylation (GO:0097502)2.89156059
106protoporphyrinogen IX metabolic process (GO:0046501)2.88817925
107neuronal action potential (GO:0019228)2.88729703
108chromatin assembly (GO:0031497)2.88194314
109negative regulation of histone methylation (GO:0031061)2.88109422
110preassembly of GPI anchor in ER membrane (GO:0016254)2.88099858
111erythrocyte maturation (GO:0043249)2.88091351
112metaphase plate congression (GO:0051310)2.87771947
113regulation of protein heterodimerization activity (GO:0043497)2.86142489
114nuclear envelope organization (GO:0006998)2.85627343
115histone exchange (GO:0043486)2.85407202
116DNA synthesis involved in DNA repair (GO:0000731)2.84573109
117negative regulation of mast cell activation (GO:0033004)2.83607563
118adaptation of signaling pathway (GO:0023058)2.83263566
119negative regulation of cytosolic calcium ion concentration (GO:0051481)2.83125675
120protein-cofactor linkage (GO:0018065)2.83020770
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.82598781
122signal peptide processing (GO:0006465)2.81952944
123gamma-aminobutyric acid transport (GO:0015812)2.81611237
1243-UTR-mediated mRNA stabilization (GO:0070935)2.80841388
125photoreceptor cell maintenance (GO:0045494)2.80366866
126DNA packaging (GO:0006323)2.79469006
127recombinational repair (GO:0000725)2.79106511
128regulation of centrosome cycle (GO:0046605)2.78855575
129respiratory chain complex IV assembly (GO:0008535)2.78565612
130double-strand break repair via homologous recombination (GO:0000724)2.78286624
131epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78196274
132IMP biosynthetic process (GO:0006188)2.76567299
133mitotic DNA integrity checkpoint (GO:0044774)2.76483955
134nucleosome assembly (GO:0006334)2.76431164
135regulation of rhodopsin mediated signaling pathway (GO:0022400)2.74602355
136dopamine transport (GO:0015872)2.74339172
137negative regulation of DNA-dependent DNA replication (GO:2000104)2.73893689
138mismatch repair (GO:0006298)2.73303673
139regulation of chromosome segregation (GO:0051983)2.72570526
140regulation of centriole replication (GO:0046599)2.71870651
141rhodopsin mediated signaling pathway (GO:0016056)2.71296736
142mitochondrial respiratory chain complex I assembly (GO:0032981)2.70800234
143NADH dehydrogenase complex assembly (GO:0010257)2.70800234
144mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.70800234
145regulation of translational fidelity (GO:0006450)2.70654353
146negative regulation of mRNA processing (GO:0050686)2.70215478
147histone-serine phosphorylation (GO:0035404)2.68167543
148kinetochore assembly (GO:0051382)2.66776236
149regulation of hippo signaling (GO:0035330)2.65696826
150DNA methylation involved in gamete generation (GO:0043046)2.65570525
151alternative mRNA splicing, via spliceosome (GO:0000380)2.65458240
152protoporphyrinogen IX biosynthetic process (GO:0006782)2.65355486
153protein complex biogenesis (GO:0070271)2.65230074
154regulation of RNA export from nucleus (GO:0046831)2.64973885
155regulation of mitotic spindle organization (GO:0060236)2.62002420
156G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.61171905
157rRNA catabolic process (GO:0016075)2.61029950
158ATP-dependent chromatin remodeling (GO:0043044)2.60632856
159positive regulation of cAMP-mediated signaling (GO:0043950)2.59911171
160nonmotile primary cilium assembly (GO:0035058)2.59352264
161negative regulation of mRNA metabolic process (GO:1903312)2.58766363
162regulation of B cell receptor signaling pathway (GO:0050855)2.58557648
163base-excision repair (GO:0006284)2.58328683
164behavioral response to ethanol (GO:0048149)2.58159238
165regulation of nuclear cell cycle DNA replication (GO:0033262)2.57395707
166spindle checkpoint (GO:0031577)2.57378036
167cilium or flagellum-dependent cell motility (GO:0001539)2.56775660
168mitotic G2/M transition checkpoint (GO:0044818)2.56670153
169negative regulation of phagocytosis (GO:0050765)2.56483120
170cilium morphogenesis (GO:0060271)2.55549621
171cornea development in camera-type eye (GO:0061303)2.53742577
172retinal cone cell development (GO:0046549)2.53695980
173photoreceptor cell development (GO:0042461)2.53490113
174negative regulation of systemic arterial blood pressure (GO:0003085)2.53488920
175amino acid salvage (GO:0043102)2.52763419
176L-methionine salvage (GO:0071267)2.52763419
177L-methionine biosynthetic process (GO:0071265)2.52763419
178spinal cord motor neuron differentiation (GO:0021522)2.51888341
179centriole replication (GO:0007099)2.51055016
180negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50886148
181negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.49719737
182negative regulation of translation, ncRNA-mediated (GO:0040033)2.49719737
183regulation of translation, ncRNA-mediated (GO:0045974)2.49719737
184epithelial cilium movement (GO:0003351)2.48863823
185RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48723587
186phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48195913
187thyroid hormone metabolic process (GO:0042403)2.46584394
188startle response (GO:0001964)2.45212739
189regulation of action potential (GO:0098900)2.45052424
190positive regulation of fatty acid transport (GO:2000193)2.44908512
191oxidative demethylation (GO:0070989)2.43852401
192aromatic amino acid family catabolic process (GO:0009074)2.43686042
193mitochondrial respiratory chain complex assembly (GO:0033108)2.43175292
194benzene-containing compound metabolic process (GO:0042537)2.42858179
195cilium organization (GO:0044782)2.42811193
196regulation of cilium movement (GO:0003352)2.41979697
197synapsis (GO:0007129)2.40432807
198reciprocal meiotic recombination (GO:0007131)2.39787266
199reciprocal DNA recombination (GO:0035825)2.39787266
200regulation of neurotransmitter uptake (GO:0051580)2.39280261

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.80927032
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.26881402
3ZNF274_21170338_ChIP-Seq_K562_Hela3.54135193
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.48495685
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22564755
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21572338
7GBX2_23144817_ChIP-Seq_PC3_Human3.21324621
8VDR_22108803_ChIP-Seq_LS180_Human3.18497537
9MYC_22102868_ChIP-Seq_BL_Human2.82475020
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.68416156
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.64928905
12EZH2_22144423_ChIP-Seq_EOC_Human2.59827297
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.55873212
14GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.55693077
15POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47007065
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.45863869
17IGF1R_20145208_ChIP-Seq_DFB_Human2.44199129
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.32272027
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.29827041
20VDR_21846776_ChIP-Seq_THP-1_Human2.29821645
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18417594
22* EWS_26573619_Chip-Seq_HEK293_Human2.18185265
23AR_21909140_ChIP-Seq_LNCAP_Human2.12876935
24TAF15_26573619_Chip-Seq_HEK293_Human2.09134773
25FUS_26573619_Chip-Seq_HEK293_Human2.07076771
26SALL1_21062744_ChIP-ChIP_HESCs_Human2.05508867
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.04939337
28P300_19829295_ChIP-Seq_ESCs_Human2.01394108
29E2F7_22180533_ChIP-Seq_HELA_Human10.4675850
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.97554570
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.95978879
32* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95615206
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94886986
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94722271
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.94062131
36ER_23166858_ChIP-Seq_MCF-7_Human1.93934314
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.81269710
38HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79037078
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.78615726
40PCGF2_27294783_Chip-Seq_ESCs_Mouse1.78131727
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.78087777
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77860133
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77742128
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77017453
45MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74303091
46MYB_21317192_ChIP-Seq_ERMYB_Mouse1.73955372
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70441854
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68248823
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66902617
50BCAT_22108803_ChIP-Seq_LS180_Human1.63829975
51STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63651324
52SCL_19346495_ChIP-Seq_HPC-7_Human1.60611456
53STAT3_23295773_ChIP-Seq_U87_Human1.59972655
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59298240
55CIITA_25753668_ChIP-Seq_RAJI_Human1.59244312
56XRN2_22483619_ChIP-Seq_HELA_Human1.59200280
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.58425849
58FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56802013
59VDR_23849224_ChIP-Seq_CD4+_Human1.56756735
60MYB_26560356_Chip-Seq_TH2_Human1.56203430
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.53423273
62CBP_20019798_ChIP-Seq_JUKART_Human1.53423273
63GATA1_22025678_ChIP-Seq_K562_Human1.53155878
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52715209
65SMAD4_21799915_ChIP-Seq_A2780_Human1.52469633
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51611531
67MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50913369
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50899880
69MAF_26560356_Chip-Seq_TH1_Human1.50608458
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.49032863
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.48755422
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.48292203
73TCF4_23295773_ChIP-Seq_U87_Human1.48125084
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.46839661
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46750550
76TP53_22573176_ChIP-Seq_HFKS_Human1.46733931
77AR_25329375_ChIP-Seq_VCAP_Human1.46602887
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46476128
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.46431470
80EST1_17652178_ChIP-ChIP_JURKAT_Human1.45564271
81VDR_24763502_ChIP-Seq_THP-1_Human1.45000750
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44525116
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43851906
84FOXP3_21729870_ChIP-Seq_TREG_Human1.43645714
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43403841
86SPI1_23547873_ChIP-Seq_NB4_Human1.43057907
87MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.42645428
88UTX_26944678_Chip-Seq_JUKART_Human1.42167427
89STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41754459
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.40464583
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40379903
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40379903
93* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.40259419
94IRF1_19129219_ChIP-ChIP_H3396_Human1.40220887
95HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39556040
96* MYB_26560356_Chip-Seq_TH1_Human1.39185579
97SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39030294
98NFE2_27457419_Chip-Seq_LIVER_Mouse1.38776085
99SOX2_19829295_ChIP-Seq_ESCs_Human1.36552771
100NANOG_19829295_ChIP-Seq_ESCs_Human1.36552771
101TCF7_22412390_ChIP-Seq_EML_Mouse1.36351546
102PCGF2_27294783_Chip-Seq_NPCs_Mouse1.35588324
103FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35522985
104FOXA1_25329375_ChIP-Seq_VCAP_Human1.35522985
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34870947
106RUNX1_22412390_ChIP-Seq_EML_Mouse1.30247491
107* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30024542
108KDM5A_27292631_Chip-Seq_BREAST_Human1.30023427
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.29574669
110SMAD3_21741376_ChIP-Seq_EPCs_Human1.29204505
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28497730
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27624981
113REST_21632747_ChIP-Seq_MESCs_Mouse1.27596417
114ELK1_19687146_ChIP-ChIP_HELA_Human1.27200281
115BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27167131
116TCF4_22108803_ChIP-Seq_LS180_Human1.27026055
117MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26662821
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25609313
119MYC_18940864_ChIP-ChIP_HL60_Human1.25420091
120PRDM14_20953172_ChIP-Seq_ESCs_Human1.25051353
121* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23561497
122TFEB_21752829_ChIP-Seq_HELA_Human1.23213020
123PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23094261
124KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.22822603
125SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22700625
126CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21570543
127CBX2_27304074_Chip-Seq_ESCs_Mouse1.21560327
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.21205886
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21195035
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20635974
131KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20219613
132NANOG_18555785_Chip-Seq_ESCs_Mouse1.19902605
133* FLI1_21867929_ChIP-Seq_TH2_Mouse1.19855985
134AR_21572438_ChIP-Seq_LNCaP_Human1.19749201
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18914891
136* ETS1_20019798_ChIP-Seq_JURKAT_Human1.18804205
137MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17845995
138RUNX2_22187159_ChIP-Seq_PCA_Human1.17421342
139* CRX_20693478_ChIP-Seq_RETINA_Mouse1.17331289
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16712839
141DCP1A_22483619_ChIP-Seq_HELA_Human1.16542008
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.16195048
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.16188672
144TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16148199
145FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15409878
146P53_22387025_ChIP-Seq_ESCs_Mouse1.15325037
147OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14378522
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13728029
149* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13234917
150HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13176012
151FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.12802634
152* IRF8_27001747_Chip-Seq_BMDM_Mouse1.11466623
153FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11149720
154STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10851579
155POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10819155
156GATA3_21878914_ChIP-Seq_MCF-7_Human1.10476105
157STAT3_18555785_Chip-Seq_ESCs_Mouse1.10090508
158KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10076241
159KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08948225
160GABP_17652178_ChIP-ChIP_JURKAT_Human1.08791087
161ZFX_18555785_ChIP-Seq_MESCs_Mouse1.08391462
162ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07214104
163AR_20517297_ChIP-Seq_VCAP_Human1.07084352
164SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06760194
165HOXB7_26014856_ChIP-Seq_BT474_Human1.04507313
166TTF2_22483619_ChIP-Seq_HELA_Human1.04253607
167TP53_16413492_ChIP-PET_HCT116_Human1.04044150
168GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03744014
169E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03646852
170SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.03582472
171EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03542083
172RNF2_27304074_Chip-Seq_NSC_Mouse1.03326210
173NCOR_22424771_ChIP-Seq_293T_Human1.03204228
174NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02663737
175GABP_19822575_ChIP-Seq_HepG2_Human1.02553783
176E2F1_18555785_Chip-Seq_ESCs_Mouse1.02375564
177DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02345923
178CDX2_22108803_ChIP-Seq_LS180_Human1.01442540
179TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01379336
180CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01084959
181SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00800915
182HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00396584
183MAF_26560356_Chip-Seq_TH2_Human1.00306746
184CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00222553
185TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00210612
186PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00138495
187CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98828140
188KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95996993
189YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95949642
190KDM2B_26808549_Chip-Seq_DND41_Human0.95897793
191PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93795898
192ELK3_25401928_ChIP-Seq_HUVEC_Human0.92494052
193THAP11_20581084_ChIP-Seq_MESCs_Mouse0.91254740
194* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90453970
195* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87971556

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.21335815
2MP0003111_abnormal_nucleus_morphology3.75895975
3MP0003195_calcinosis3.64503948
4MP0003693_abnormal_embryo_hatching3.42464722
5MP0008057_abnormal_DNA_replication3.26339899
6MP0002396_abnormal_hematopoietic_system3.24275524
7MP0003077_abnormal_cell_cycle3.18608353
8MP0004957_abnormal_blastocyst_morpholog2.71416575
9MP0010307_abnormal_tumor_latency2.68530740
10MP0005551_abnormal_eye_electrophysiolog2.49332671
11MP0010352_gastrointestinal_tract_polyps2.48488040
12MP0002102_abnormal_ear_morphology2.46996243
13MP0002837_dystrophic_cardiac_calcinosis2.38208827
14MP0001968_abnormal_touch/_nociception2.35547244
15MP0004808_abnormal_hematopoietic_stem2.32130752
16MP0003303_peritoneal_inflammation2.31621653
17MP0001835_abnormal_antigen_presentation2.24016920
18MP0005076_abnormal_cell_differentiation2.21187562
19MP0006054_spinal_hemorrhage2.20374007
20MP0003646_muscle_fatigue2.16360794
21MP0003656_abnormal_erythrocyte_physiolo2.15336514
22MP0002398_abnormal_bone_marrow2.15234115
23MP0008872_abnormal_physiological_respon2.07527242
24MP0003300_gastrointestinal_ulcer2.06220648
25MP0000685_abnormal_immune_system2.05887860
26MP0009046_muscle_twitch2.04229363
27MP0001800_abnormal_humoral_immune1.99824718
28MP0005397_hematopoietic_system_phenotyp1.96154643
29MP0001545_abnormal_hematopoietic_system1.96154643
30MP0008007_abnormal_cellular_replicative1.95573688
31MP0006072_abnormal_retinal_apoptosis1.94290341
32MP0001501_abnormal_sleep_pattern1.91950246
33MP0000350_abnormal_cell_proliferation1.91729762
34MP0002876_abnormal_thyroid_physiology1.89272560
35MP0004142_abnormal_muscle_tone1.87947875
36MP0004043_abnormal_pH_regulation1.86033393
37MP0002166_altered_tumor_susceptibility1.85475380
38MP0000372_irregular_coat_pigmentation1.84816149
39MP0000703_abnormal_thymus_morphology1.83876160
40MP0001485_abnormal_pinna_reflex1.83462248
41MP0002722_abnormal_immune_system1.80201764
42MP0008058_abnormal_DNA_repair1.79448841
43MP0009745_abnormal_behavioral_response1.78096694
44MP0002452_abnormal_antigen_presenting1.77782714
45MP0002736_abnormal_nociception_after1.77529838
46MP0005671_abnormal_response_to1.77167448
47MP0009278_abnormal_bone_marrow1.75844737
48MP0001986_abnormal_taste_sensitivity1.75445529
49MP0000689_abnormal_spleen_morphology1.75332308
50MP0005253_abnormal_eye_physiology1.73480527
51MP0003763_abnormal_thymus_physiology1.72865322
52MP0002638_abnormal_pupillary_reflex1.72372187
53MP0001730_embryonic_growth_arrest1.70946873
54MP0002877_abnormal_melanocyte_morpholog1.70738529
55MP0005645_abnormal_hypothalamus_physiol1.69356449
56MP0002420_abnormal_adaptive_immunity1.69231737
57MP0005646_abnormal_pituitary_gland1.67462218
58MP0001819_abnormal_immune_cell1.67327412
59MP0003436_decreased_susceptibility_to1.66952224
60MP0000490_abnormal_crypts_of1.66585760
61MP0000427_abnormal_hair_cycle1.65949699
62MP0003705_abnormal_hypodermis_morpholog1.63456551
63MP0008875_abnormal_xenobiotic_pharmacok1.63203531
64MP0000569_abnormal_digit_pigmentation1.63117525
65MP0002938_white_spotting1.61895577
66MP0000716_abnormal_immune_system1.61499767
67MP0002272_abnormal_nervous_system1.61144595
68MP0003136_yellow_coat_color1.59924079
69MP0002019_abnormal_tumor_incidence1.59327462
70MP0002429_abnormal_blood_cell1.59029411
71MP0004133_heterotaxia1.58353148
72MP0005000_abnormal_immune_tolerance1.57639750
73MP0005387_immune_system_phenotype1.57311296
74MP0001790_abnormal_immune_system1.57311296
75MP0006292_abnormal_olfactory_placode1.55953216
76MP0002723_abnormal_immune_serum1.54294428
77MP0004885_abnormal_endolymph1.52847234
78MP0000631_abnormal_neuroendocrine_gland1.46892031
79MP0009333_abnormal_splenocyte_physiolog1.44710686
80MP0002006_tumorigenesis1.44511340
81MP0005464_abnormal_platelet_physiology1.43089338
82MP0008877_abnormal_DNA_methylation1.41289181
83MP0002405_respiratory_system_inflammati1.39118629
84MP0005025_abnormal_response_to1.35502089
85MP0005389_reproductive_system_phenotype1.34332559
86MP0000313_abnormal_cell_death1.34041428
87MP0002419_abnormal_innate_immunity1.33484168
88MP0003880_abnormal_central_pattern1.33320468
89MP0006276_abnormal_autonomic_nervous1.32933294
90MP0003011_delayed_dark_adaptation1.32781151
91MP0008932_abnormal_embryonic_tissue1.31855384
92MP0001486_abnormal_startle_reflex1.30778608
93MP0002735_abnormal_chemical_nociception1.28717102
94MP0002064_seizures1.27710673
95MP0005084_abnormal_gallbladder_morpholo1.26353803
96MP0002160_abnormal_reproductive_system1.25956868
97MP0004147_increased_porphyrin_level1.23063677
98MP0004742_abnormal_vestibular_system1.22599794
99MP0002572_abnormal_emotion/affect_behav1.20832393
100MP0004947_skin_inflammation1.20443771
101MP0001697_abnormal_embryo_size1.19827099
102MP0000858_altered_metastatic_potential1.18566883
103MP0002080_prenatal_lethality1.17935243
104MP0003718_maternal_effect1.17524390
105MP0004145_abnormal_muscle_electrophysio1.16433995
106MP0001919_abnormal_reproductive_system1.16419636
107MP0009785_altered_susceptibility_to1.15352863
108MP0004197_abnormal_fetal_growth/weight/1.15313390
109MP0005380_embryogenesis_phenotype1.15030532
110MP0001672_abnormal_embryogenesis/_devel1.15030532
111MP0000465_gastrointestinal_hemorrhage1.14115170
112MP0003566_abnormal_cell_adhesion1.13999122
113MP0003984_embryonic_growth_retardation1.13285592
114MP0001970_abnormal_pain_threshold1.12863865
115MP0001853_heart_inflammation1.11750874
116MP0005386_behavior/neurological_phenoty1.11713618
117MP0004924_abnormal_behavior1.11713618
118MP0002928_abnormal_bile_duct1.11530959
119MP0002086_abnormal_extraembryonic_tissu1.11197584
120MP0002733_abnormal_thermal_nociception1.11030047
121MP0002088_abnormal_embryonic_growth/wei1.10197114
122MP0005171_absent_coat_pigmentation1.09322245
123MP0001873_stomach_inflammation1.09057536
124MP0003448_altered_tumor_morphology1.08978557
125MP0002138_abnormal_hepatobiliary_system1.07674667
126MP0002557_abnormal_social/conspecific_i1.07102353
127MP0005075_abnormal_melanosome_morpholog1.07038772
128MP0002009_preneoplasia1.06723933
129MP0002067_abnormal_sensory_capabilities1.06543648
130MP0001529_abnormal_vocalization1.05493937
131MP0003123_paternal_imprinting1.04708596
132MP0002693_abnormal_pancreas_physiology1.04264504
133MP0010155_abnormal_intestine_physiology1.03029312
134MP0002277_abnormal_respiratory_mucosa1.02947104
135MP0010386_abnormal_urinary_bladder1.02548599
136MP0003172_abnormal_lysosome_physiology1.01889671
137MP0002653_abnormal_ependyma_morphology1.01809254
138MP0003567_abnormal_fetal_cardiomyocyte1.01800406
139MP0003121_genomic_imprinting1.01746606
140MP0005167_abnormal_blood-brain_barrier1.01504690
141MP0002751_abnormal_autonomic_nervous0.99379168
142MP0001984_abnormal_olfaction0.98753458
143MP0005621_abnormal_cell_physiology0.98199688
144MP0001905_abnormal_dopamine_level0.98000518
145MP0000230_abnormal_systemic_arterial0.95653250
146MP0005195_abnormal_posterior_eye0.94559678
147MP0005174_abnormal_tail_pigmentation0.94447214
148MP0005410_abnormal_fertilization0.92839058
149MP0001845_abnormal_inflammatory_respons0.90805373
150MP0002163_abnormal_gland_morphology0.90374840
151MP0005023_abnormal_wound_healing0.89852240
152MP0000015_abnormal_ear_pigmentation0.88345112
153MP0005379_endocrine/exocrine_gland_phen0.87492624
154MP0004215_abnormal_myocardial_fiber0.87251841
155MP0001915_intracranial_hemorrhage0.87181688
156MP0005384_cellular_phenotype0.86637030
157MP0002734_abnormal_mechanical_nocicepti0.86446519
158MP0003122_maternal_imprinting0.86342920
159MP0002063_abnormal_learning/memory/cond0.86247822
160MP0002148_abnormal_hypersensitivity_rea0.85636997
161MP0003635_abnormal_synaptic_transmissio0.85592930
162MP0001324_abnormal_eye_pigmentation0.85468791
163MP0002095_abnormal_skin_pigmentation0.85445445
164MP0000647_abnormal_sebaceous_gland0.84727605
165MP0003866_abnormal_defecation0.84258478
166MP0001764_abnormal_homeostasis0.83371693
167MP0003252_abnormal_bile_duct0.81835036
168MP0000383_abnormal_hair_follicle0.81696364
169MP0003698_abnormal_male_reproductive0.81672937
170MP0008770_decreased_survivor_rate0.80804521
171MP0008995_early_reproductive_senescence0.80616053
172MP0003091_abnormal_cell_migration0.80223797
173MP0002229_neurodegeneration0.79662939
174MP0002085_abnormal_embryonic_tissue0.78930261
175MP0002084_abnormal_developmental_patter0.78742695
176MP0003890_abnormal_embryonic-extraembry0.78380806
177MP0008775_abnormal_heart_ventricle0.77993094
178MP0005332_abnormal_amino_acid0.77973112
179MP0003787_abnormal_imprinting0.77838414
180MP0001929_abnormal_gametogenesis0.77071546
181MP0010329_abnormal_lipoprotein_level0.75334483
182MP0001944_abnormal_pancreas_morphology0.73647644
183MP0005187_abnormal_penis_morphology0.73105933
184MP0002210_abnormal_sex_determination0.72389070
185MP0002933_joint_inflammation0.72292089
186MP0001963_abnormal_hearing_physiology0.72094771
187MP0003786_premature_aging0.69714142
188MP0000733_abnormal_muscle_development0.69327760
189MP0000371_diluted_coat_color0.68277018
190MP0000358_abnormal_cell_content/0.63524557
191MP0003943_abnormal_hepatobiliary_system0.62846567

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.46838574
2Pancreatic fibrosis (HP:0100732)4.04381769
3Abnormality of midbrain morphology (HP:0002418)3.94651798
4Molar tooth sign on MRI (HP:0002419)3.94651798
5True hermaphroditism (HP:0010459)3.87943909
6Nephronophthisis (HP:0000090)3.75325933
7Congenital stationary night blindness (HP:0007642)3.74036089
8Papilledema (HP:0001085)3.46528410
9Chromsome breakage (HP:0040012)3.42900295
10Elevated erythrocyte sedimentation rate (HP:0003565)3.42067214
11Hyperventilation (HP:0002883)3.28760978
12Recurrent viral infections (HP:0004429)3.25026273
13Abnormality of the renal medulla (HP:0100957)3.22691411
14Abnormality of the renal cortex (HP:0011035)3.15961254
15Type II lissencephaly (HP:0007260)3.14253511
16Volvulus (HP:0002580)3.09835434
17Attenuation of retinal blood vessels (HP:0007843)3.02193702
18Abnormality of the fingertips (HP:0001211)2.94597215
19Thrombocytosis (HP:0001894)2.93204769
20Medial flaring of the eyebrow (HP:0010747)2.92374977
21High pitched voice (HP:0001620)2.88673623
22Abnormality of chromosome stability (HP:0003220)2.86906866
23Pendular nystagmus (HP:0012043)2.85068253
24Poikilocytosis (HP:0004447)2.83815049
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.83335057
26Abolished electroretinogram (ERG) (HP:0000550)2.81790555
27Cellulitis (HP:0100658)2.78441174
28Reticulocytopenia (HP:0001896)2.77708532
29Abnormality of B cell number (HP:0010975)2.75230299
30B lymphocytopenia (HP:0010976)2.75230299
31Myositis (HP:0100614)2.70107835
32Gaze-evoked nystagmus (HP:0000640)2.69325755
33Birth length less than 3rd percentile (HP:0003561)2.68873831
34IgM deficiency (HP:0002850)2.65760326
35Tubular atrophy (HP:0000092)2.65681943
36Cystic liver disease (HP:0006706)2.62358953
37Hypothermia (HP:0002045)2.60862549
38Increased nuchal translucency (HP:0010880)2.59161928
39Increased density of long bones (HP:0006392)2.56771388
40Progressive inability to walk (HP:0002505)2.54441747
41Panhypogammaglobulinemia (HP:0003139)2.54360390
42Decreased central vision (HP:0007663)2.54267657
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.53894772
44Recurrent fungal infections (HP:0002841)2.52441823
45Large for gestational age (HP:0001520)2.50322200
46T lymphocytopenia (HP:0005403)2.49320997
47Myelodysplasia (HP:0002863)2.49206371
48Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.49113157
49Abnormality of alanine metabolism (HP:0010916)2.49113157
50Hyperalaninemia (HP:0003348)2.49113157
51Inability to walk (HP:0002540)2.48598564
52Congenital, generalized hypertrichosis (HP:0004540)2.48392335
53Renal cortical cysts (HP:0000803)2.47941498
54Protruding tongue (HP:0010808)2.46388249
55Cutaneous melanoma (HP:0012056)2.45998931
56Proximal placement of thumb (HP:0009623)2.44727577
57Broad-based gait (HP:0002136)2.44488060
58Abnormal rod and cone electroretinograms (HP:0008323)2.43116218
59Deviation of the thumb (HP:0009603)2.42888356
60Fair hair (HP:0002286)2.42351225
61Prominent nose (HP:0000448)2.41448793
62Ectopic kidney (HP:0000086)2.40682405
63Basal cell carcinoma (HP:0002671)2.40063029
64Abnormality of reticulocytes (HP:0004312)2.39678124
65Chronic hepatic failure (HP:0100626)2.39573170
66Keratoconus (HP:0000563)2.37760669
67Increased corneal curvature (HP:0100692)2.37760669
68Sclerocornea (HP:0000647)2.36790520
69Lymphoma (HP:0002665)2.33627479
70Recurrent abscess formation (HP:0002722)2.32778529
71Abnormality of the pons (HP:0007361)2.31986486
72Progressive cerebellar ataxia (HP:0002073)2.31644381
73Furrowed tongue (HP:0000221)2.31059617
74Abnormality of T cell number (HP:0011839)2.29722169
75Poikiloderma (HP:0001029)2.28599195
76Polydipsia (HP:0001959)2.27309484
77Abnormal drinking behavior (HP:0030082)2.27309484
78Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27162623
79Methylmalonic acidemia (HP:0002912)2.26888745
80Retrobulbar optic neuritis (HP:0100654)2.26536246
81Optic neuritis (HP:0100653)2.26536246
82Petechiae (HP:0000967)2.23187585
83Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.22166512
84Short 4th metacarpal (HP:0010044)2.22166512
85Congenital sensorineural hearing impairment (HP:0008527)2.21218273
86Genetic anticipation (HP:0003743)2.20674152
87Hypoplasia of the pons (HP:0012110)2.20085622
88Hemiparesis (HP:0001269)2.19880667
89Anencephaly (HP:0002323)2.19332038
90Hyperacusis (HP:0010780)2.18453650
91Lissencephaly (HP:0001339)2.18295928
92Reticulocytosis (HP:0001923)2.18286020
93Cafe-au-lait spot (HP:0000957)2.17908418
94Abnormality of T cells (HP:0002843)2.16896638
95Febrile seizures (HP:0002373)2.16483521
96Entropion (HP:0000621)2.16360230
97Verrucae (HP:0200043)2.16323087
98Papilloma (HP:0012740)2.16323087
99Agnosia (HP:0010524)2.16254311
100Congenital hepatic fibrosis (HP:0002612)2.16055662
101Cerebellar dysplasia (HP:0007033)2.13870680
102Gait imbalance (HP:0002141)2.12211770
103Meningitis (HP:0001287)2.11327278
104Absent rod-and cone-mediated responses on ERG (HP:0007688)2.10005807
105Squamous cell carcinoma (HP:0002860)2.09446343
106Aplasia/Hypoplasia of the tongue (HP:0010295)2.09304415
107Abnormality of the preputium (HP:0100587)2.09018353
108Gastrointestinal infarctions (HP:0005244)2.08564070
109Congenital primary aphakia (HP:0007707)2.07434829
110Orchitis (HP:0100796)2.07264638
111Focal motor seizures (HP:0011153)2.07037116
112Male pseudohermaphroditism (HP:0000037)2.06605339
113Chronic otitis media (HP:0000389)2.06467861
114Abnormality of the peritoneum (HP:0002585)2.04453684
1153-Methylglutaconic aciduria (HP:0003535)2.04001230
116Increased CSF lactate (HP:0002490)2.03536996
117Combined immunodeficiency (HP:0005387)2.03533424
118Dialeptic seizures (HP:0011146)2.03083510
119Aplasia/Hypoplasia of the thymus (HP:0010515)2.02942981
120Methylmalonic aciduria (HP:0012120)2.02127234
121Thyroiditis (HP:0100646)2.01741894
122Acute necrotizing encephalopathy (HP:0006965)2.01580837
123Osteomyelitis (HP:0002754)2.01523676
124Recurrent bacterial skin infections (HP:0005406)2.01135656
125Abnormality of DNA repair (HP:0003254)2.00924374
126Slender long bone (HP:0003100)2.00493750
127Aplasia/Hypoplasia of the uvula (HP:0010293)2.00367799
128Recurrent bronchitis (HP:0002837)1.99908026
129Abnormal platelet volume (HP:0011876)1.99361285
130Eczematoid dermatitis (HP:0000976)1.99200484
131Ketoacidosis (HP:0001993)1.98419345
132Absent speech (HP:0001344)1.98164555
133Eosinophilia (HP:0001880)1.97455675
134Leukocytosis (HP:0001974)1.97407320
135Progressive macrocephaly (HP:0004481)1.97169814
136Peritonitis (HP:0002586)1.96869586
137Severe muscular hypotonia (HP:0006829)1.96867779
138Focal seizures (HP:0007359)1.96293343
139Meckel diverticulum (HP:0002245)1.95660551
140Abnormal delayed hypersensitivity skin test (HP:0002963)1.95332157
141Postaxial foot polydactyly (HP:0001830)1.95189649
142Abnormality of the carotid arteries (HP:0005344)1.94803835
143Long eyelashes (HP:0000527)1.94228003
144Abnormality of cells of the erythroid lineage (HP:0012130)1.94054472
145Mitochondrial inheritance (HP:0001427)1.93753443
146Severe combined immunodeficiency (HP:0004430)1.93626333
147Selective tooth agenesis (HP:0001592)1.92535523
148Chest pain (HP:0100749)1.91988215
149Acute myeloid leukemia (HP:0004808)1.91695621
150Generalized hypopigmentation of hair (HP:0011358)1.89792682
151Abnormal number of erythroid precursors (HP:0012131)1.89638638
152Gastrointestinal inflammation (HP:0004386)1.89552527
153Bile duct proliferation (HP:0001408)1.89411411
154Abnormal biliary tract physiology (HP:0012439)1.89411411
155Agitation (HP:0000713)1.89013728
156Genital tract atresia (HP:0001827)1.87936276
157Pallor (HP:0000980)1.87828791
158Spinal muscular atrophy (HP:0007269)1.87707684
159Leukopenia (HP:0001882)1.87019506
160Small hand (HP:0200055)1.86990368
161Optic nerve hypoplasia (HP:0000609)1.86717808
162Clumsiness (HP:0002312)1.86404760
163Nephrogenic diabetes insipidus (HP:0009806)1.86177120
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.85730071
165Inflammation of the large intestine (HP:0002037)1.85506431
166Absent/shortened dynein arms (HP:0200106)1.85461771
167Dynein arm defect of respiratory motile cilia (HP:0012255)1.85461771
168Polyuria (HP:0000103)1.85308719
169Bone marrow hypocellularity (HP:0005528)1.85150693
170Impulsivity (HP:0100710)1.84812246
171IgA deficiency (HP:0002720)1.84461895
172Arterial thrombosis (HP:0004420)1.83909226
173Granulocytopenia (HP:0001913)1.83763424
174Chorioretinal atrophy (HP:0000533)1.83724597
175Bony spicule pigmentary retinopathy (HP:0007737)1.83568990
176Colon cancer (HP:0003003)1.83347983
177Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83154772
178Intestinal atresia (HP:0011100)1.83146932
179Acute encephalopathy (HP:0006846)1.82251579
180Optic disc pallor (HP:0000543)1.81954837
181Agammaglobulinemia (HP:0004432)1.81869380
182Duodenal stenosis (HP:0100867)1.81747269
183Small intestinal stenosis (HP:0012848)1.81747269
184Bicuspid aortic valve (HP:0001647)1.81215797
185Abnormality of T cell physiology (HP:0011840)1.81132777
186Impaired platelet aggregation (HP:0003540)1.80707563
187Abnormal platelet function (HP:0011869)1.80707563
188Abnormality of the labia minora (HP:0012880)1.80698428
189Decreased circulating renin level (HP:0003351)1.80601980
190Abnormality of the ileum (HP:0001549)1.79369130
191Stomach cancer (HP:0012126)1.79201766
192Vaginal atresia (HP:0000148)1.79201427
193Amaurosis fugax (HP:0100576)1.78454543
194Ketosis (HP:0001946)1.77756122
195Abnormal respiratory motile cilium morphology (HP:0005938)1.76461862
196Abnormal respiratory epithelium morphology (HP:0012253)1.76461862
197Concave nail (HP:0001598)1.75134282
198Aplasia/Hypoplasia of the spleen (HP:0010451)1.72749285

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.92521883
2CDC74.13713099
3ADRBK23.44903716
4CDK123.39889911
5MAP4K13.17015962
6EEF2K3.03041149
7NEK22.77004719
8BMPR1B2.69646242
9WEE12.57753662
10MAP4K22.53404669
11GRK12.46832670
12WNK32.46802022
13PKN22.39348233
14CASK2.34716991
15NUAK12.25359231
16MAP3K102.23753884
17STK102.20622176
18SCYL22.18169144
19BRD42.12301294
20INSRR1.99667457
21PINK11.97811961
22STK41.97151173
23WNK41.95975846
24TLK11.94290629
25TRIM281.81195332
26OXSR11.80672308
27MAPK131.80516694
28BUB11.80078942
29CCNB11.74551298
30CDK41.63842874
31TESK21.63749865
32ACVR1B1.59391556
33EIF2AK11.57828593
34AURKB1.53776434
35CDK61.50886210
36STK391.50284679
37NEK11.48921463
38MAP3K81.47121450
39MKNK21.45992531
40TTK1.45157212
41MAP3K41.44993972
42TNIK1.44467152
43ATR1.42032561
44MST41.39872187
45TYK21.35381052
46GRK61.35152649
47PIM11.34629310
48ADRBK11.32659397
49PAK31.31885302
50LRRK21.26913535
51TRIB31.25600602
52RPS6KB21.22916871
53PLK11.21250565
54TTN1.20558344
55DAPK21.18895748
56PNCK1.14872221
57FLT31.12086804
58PASK1.11517421
59RPS6KA41.10532960
60CLK11.08819642
61CHEK11.08146417
62BTK1.06393180
63SRPK11.06050006
64ZAP701.05572059
65PLK21.04874014
66PRKCE1.03986051
67CSF1R1.03726163
68BRSK21.03073136
69PTK2B1.02821473
70PRKCG1.01403315
71SYK1.01019501
72JAK30.98472331
73VRK10.98309092
74NTRK30.97879814
75CHEK20.97104249
76BRSK10.96383849
77PHKG10.93260747
78PHKG20.93260747
79CDK70.92784941
80NME20.91827104
81DYRK20.91140897
82TSSK60.90622939
83MARK10.86640162
84ITK0.86219974
85CAMKK20.85992538
86DYRK30.84429108
87IRAK10.84283149
88MKNK10.84223835
89ATM0.82316204
90PIM20.81828376
91TESK10.81796548
92ALK0.81357071
93KIT0.80859278
94NLK0.80045482
95MAP2K70.79846172
96STK30.77244882
97FGFR20.76014646
98MAP2K30.73156407
99TEC0.72686765
100RPS6KA50.72400703
101ZAK0.70429485
102NEK90.70173992
103CSNK1G10.69861195
104CDK20.69627828
105TRPM70.69584623
106IRAK40.69491970
107MELK0.64913677
108CSNK1G20.64771347
109SIK20.63461662
110HCK0.62798210
111TBK10.62494581
112MAP2K60.60934954
113LCK0.60801178
114PRKCQ0.60443042
115PRKCI0.59726572
116PLK30.59511396
117PAK40.59499536
118TGFBR10.58670349
119ERBB30.58505975
120CAMK2A0.58065596
121PTK60.57758063
122MAP3K140.57240241
123CDK90.57043789
124MAPKAPK50.55728119
125STK38L0.54940649
126TAOK30.54851921
127CDK10.54399533
128CAMK1G0.54337423
129PKN10.53970723
130AURKA0.53723834
131LYN0.53105329
132CSNK1G30.52426243
133MAPK110.51394397
134RPS6KA60.51260563
135RAF10.50981756
136RPS6KC10.50969381
137RPS6KL10.50969381
138PAK20.50827177
139ERN10.50767313
140STK110.47917765
141MUSK0.47544714
142MTOR0.47235310
143TXK0.46155300
144PRKDC0.45988022
145NME10.45513856
146CDK30.44744981
147MAPKAPK30.44542132
148MARK30.44115336
149TNK20.42779285
150PIK3CA0.42439849
151PRKACA0.42315012
152EIF2AK30.42043234
153CSK0.41948334
154OBSCN0.41769866
155CSNK1A1L0.41003128
156CHUK0.40817510
157PRKAA20.40539546
158PLK40.40159794
159IKBKB0.39827890
160SGK20.38626541
161FER0.38529539
162TAF10.37492489
163AKT30.37408583
164MAPK150.36596665
165GRK70.36416383
166PRKCZ0.36105632
167CSNK1A10.36082362
168PIK3CG0.35709248
169CAMK10.35260590
170PRKG10.33915412
171BCKDK0.33118343
172PRKAA10.32017601
173EPHA30.31879932
174TIE10.31671231
175PRKCA0.30733342

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.73192113
2Mismatch repair_Homo sapiens_hsa034303.72644570
3Phototransduction_Homo sapiens_hsa047442.92397680
4Cell cycle_Homo sapiens_hsa041102.81383215
5Systemic lupus erythematosus_Homo sapiens_hsa053222.77635643
6Base excision repair_Homo sapiens_hsa034102.71301232
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.65654496
8Linoleic acid metabolism_Homo sapiens_hsa005912.49402340
9Homologous recombination_Homo sapiens_hsa034402.48693112
10Butanoate metabolism_Homo sapiens_hsa006502.48371109
11Non-homologous end-joining_Homo sapiens_hsa034502.38695476
12Nitrogen metabolism_Homo sapiens_hsa009102.37738751
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37548931
14Nucleotide excision repair_Homo sapiens_hsa034202.29620466
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28884175
16One carbon pool by folate_Homo sapiens_hsa006702.25122117
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.24490813
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23501708
19Spliceosome_Homo sapiens_hsa030402.15031812
20Nicotine addiction_Homo sapiens_hsa050332.12534000
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.11159244
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.99094349
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.97227149
24RNA transport_Homo sapiens_hsa030131.96283884
25Fanconi anemia pathway_Homo sapiens_hsa034601.96044779
26Oxidative phosphorylation_Homo sapiens_hsa001901.95463487
27Tryptophan metabolism_Homo sapiens_hsa003801.93024957
28Primary immunodeficiency_Homo sapiens_hsa053401.90040579
29Protein export_Homo sapiens_hsa030601.89693508
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.89346574
31Selenocompound metabolism_Homo sapiens_hsa004501.87970752
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83181206
33Ether lipid metabolism_Homo sapiens_hsa005651.82113206
34p53 signaling pathway_Homo sapiens_hsa041151.79052078
35Viral carcinogenesis_Homo sapiens_hsa052031.76560025
36Antigen processing and presentation_Homo sapiens_hsa046121.72375400
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70628345
38B cell receptor signaling pathway_Homo sapiens_hsa046621.58890345
39Caffeine metabolism_Homo sapiens_hsa002321.56122025
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50125849
41Parkinsons disease_Homo sapiens_hsa050121.47896451
42Chronic myeloid leukemia_Homo sapiens_hsa052201.43974842
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.39673914
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.37900467
45Taste transduction_Homo sapiens_hsa047421.36514949
46Herpes simplex infection_Homo sapiens_hsa051681.34261859
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29080191
48mRNA surveillance pathway_Homo sapiens_hsa030151.29047543
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28743135
50Measles_Homo sapiens_hsa051621.26952967
51Alcoholism_Homo sapiens_hsa050341.26462308
52Propanoate metabolism_Homo sapiens_hsa006401.25920665
53Leishmaniasis_Homo sapiens_hsa051401.25842365
54Small cell lung cancer_Homo sapiens_hsa052221.24132755
55Epstein-Barr virus infection_Homo sapiens_hsa051691.23299782
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22911220
57Olfactory transduction_Homo sapiens_hsa047401.22407033
58Hepatitis B_Homo sapiens_hsa051611.21751055
59Hematopoietic cell lineage_Homo sapiens_hsa046401.20244478
60Primary bile acid biosynthesis_Homo sapiens_hsa001201.20230897
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.19340793
62Morphine addiction_Homo sapiens_hsa050321.19126199
63Apoptosis_Homo sapiens_hsa042101.19006165
64Chemical carcinogenesis_Homo sapiens_hsa052041.18974807
65Ribosome_Homo sapiens_hsa030101.18198706
66Pyrimidine metabolism_Homo sapiens_hsa002401.15977440
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14080708
68HTLV-I infection_Homo sapiens_hsa051661.13885728
69RNA degradation_Homo sapiens_hsa030181.12275194
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.10355715
71MicroRNAs in cancer_Homo sapiens_hsa052061.09993120
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.08781652
73ABC transporters_Homo sapiens_hsa020101.07267531
74Peroxisome_Homo sapiens_hsa041461.07178454
75Transcriptional misregulation in cancer_Homo sapiens_hsa052021.07176631
76Pancreatic cancer_Homo sapiens_hsa052121.06759047
77Insulin secretion_Homo sapiens_hsa049111.06347209
78Arachidonic acid metabolism_Homo sapiens_hsa005901.03797294
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02982464
80Legionellosis_Homo sapiens_hsa051341.01844120
81T cell receptor signaling pathway_Homo sapiens_hsa046601.01804150
82Viral myocarditis_Homo sapiens_hsa054161.00873008
83Retinol metabolism_Homo sapiens_hsa008300.99437138
84Serotonergic synapse_Homo sapiens_hsa047260.99294274
85Non-small cell lung cancer_Homo sapiens_hsa052230.99213504
86Osteoclast differentiation_Homo sapiens_hsa043800.98183724
87Shigellosis_Homo sapiens_hsa051310.97498275
88Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96387711
89Huntingtons disease_Homo sapiens_hsa050160.95756528
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94784527
91Sulfur metabolism_Homo sapiens_hsa009200.94396289
92Regulation of autophagy_Homo sapiens_hsa041400.94227826
93Intestinal immune network for IgA production_Homo sapiens_hsa046720.94014042
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93046693
95Glutamatergic synapse_Homo sapiens_hsa047240.92095788
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.91306604
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90418626
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89946435
99Cardiac muscle contraction_Homo sapiens_hsa042600.89279164
100Glycerolipid metabolism_Homo sapiens_hsa005610.89128125
101Circadian entrainment_Homo sapiens_hsa047130.88100035
102Alzheimers disease_Homo sapiens_hsa050100.86956937
103Collecting duct acid secretion_Homo sapiens_hsa049660.86076894
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86042775
105GABAergic synapse_Homo sapiens_hsa047270.85851753
106Oocyte meiosis_Homo sapiens_hsa041140.84756017
107Colorectal cancer_Homo sapiens_hsa052100.84473838
108Ovarian steroidogenesis_Homo sapiens_hsa049130.82588915
109Toxoplasmosis_Homo sapiens_hsa051450.82557776
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79671847
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79538308
112Acute myeloid leukemia_Homo sapiens_hsa052210.78306236
113RNA polymerase_Homo sapiens_hsa030200.77865160
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.74006136
115Influenza A_Homo sapiens_hsa051640.73620749
116Tuberculosis_Homo sapiens_hsa051520.73261119
117Steroid biosynthesis_Homo sapiens_hsa001000.71401122
118Dorso-ventral axis formation_Homo sapiens_hsa043200.69633176
119Asthma_Homo sapiens_hsa053100.69571573
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67880311
121Fat digestion and absorption_Homo sapiens_hsa049750.67492517
122Calcium signaling pathway_Homo sapiens_hsa040200.67443772
123Platelet activation_Homo sapiens_hsa046110.67239639
124Toll-like receptor signaling pathway_Homo sapiens_hsa046200.67112314
125Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66951483
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65779827
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65725361
128beta-Alanine metabolism_Homo sapiens_hsa004100.65475488
129Malaria_Homo sapiens_hsa051440.64701917
130Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64564104
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.63948662
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.63613229
133Bladder cancer_Homo sapiens_hsa052190.60683030
134Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60135677
135Type I diabetes mellitus_Homo sapiens_hsa049400.59593257
136Mineral absorption_Homo sapiens_hsa049780.59001321
137Chemokine signaling pathway_Homo sapiens_hsa040620.58552841
138Lysine degradation_Homo sapiens_hsa003100.57656059
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.57604664
140Histidine metabolism_Homo sapiens_hsa003400.57321688
141Metabolic pathways_Homo sapiens_hsa011000.57271680
142Salivary secretion_Homo sapiens_hsa049700.56726702
143Pertussis_Homo sapiens_hsa051330.55974896
144Proteasome_Homo sapiens_hsa030500.55412181
145Cyanoamino acid metabolism_Homo sapiens_hsa004600.55277669
146Vitamin B6 metabolism_Homo sapiens_hsa007500.54960770
147Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54849708
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54614299
149Basal transcription factors_Homo sapiens_hsa030220.54007123
150AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52801114
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52216877
152mTOR signaling pathway_Homo sapiens_hsa041500.52200062
153Pentose phosphate pathway_Homo sapiens_hsa000300.51744575
154Prostate cancer_Homo sapiens_hsa052150.51631439
155Glycerophospholipid metabolism_Homo sapiens_hsa005640.49560534
156Long-term depression_Homo sapiens_hsa047300.49506614
157VEGF signaling pathway_Homo sapiens_hsa043700.49405153
158Cysteine and methionine metabolism_Homo sapiens_hsa002700.48257012
159Dopaminergic synapse_Homo sapiens_hsa047280.48036502
160TNF signaling pathway_Homo sapiens_hsa046680.47628519
161FoxO signaling pathway_Homo sapiens_hsa040680.45418577
162Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.45070744
163SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44641024
164N-Glycan biosynthesis_Homo sapiens_hsa005100.44587869
165HIF-1 signaling pathway_Homo sapiens_hsa040660.44239214
166Vitamin digestion and absorption_Homo sapiens_hsa049770.44149737
167Thyroid cancer_Homo sapiens_hsa052160.43682791
168Glioma_Homo sapiens_hsa052140.43247459
169Circadian rhythm_Homo sapiens_hsa047100.42795607
170Proteoglycans in cancer_Homo sapiens_hsa052050.42707826
171Salmonella infection_Homo sapiens_hsa051320.41568086
172Fatty acid degradation_Homo sapiens_hsa000710.39691926
173Central carbon metabolism in cancer_Homo sapiens_hsa052300.38635595
174Sulfur relay system_Homo sapiens_hsa041220.36758276
175Pathways in cancer_Homo sapiens_hsa052000.35541726
176Allograft rejection_Homo sapiens_hsa053300.33800039
177Graft-versus-host disease_Homo sapiens_hsa053320.33696579
178Vascular smooth muscle contraction_Homo sapiens_hsa042700.32875722
179Purine metabolism_Homo sapiens_hsa002300.32824081
180Cocaine addiction_Homo sapiens_hsa050300.32394263
181Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31388542
182Glycosaminoglycan degradation_Homo sapiens_hsa005310.31021444
183Rheumatoid arthritis_Homo sapiens_hsa053230.29719355
184Amphetamine addiction_Homo sapiens_hsa050310.28117339

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